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  • Pheochromocytoma  (3)
  • Saralasin  (2)
  • adulteration of essential oils  (2)
  • 1
    Electronic Resource
    Electronic Resource
    2H NMR determination of site-specific natural isotope fractionation in (-)-α-bisabolols
    Amsterdam : Elsevier
    Phytochemistry 31 (1991), S. 171-174 
    Details
    ISSN: 0031-9422
    Keywords: (-)-α-bisabolol ; Chamomilla recutita, Vanillosmopsis erythropappa ; Compositae ; adulteration of essential oils ; quantitative deuterium NMR spectroscopy. ; site-specific natural isotope fractionation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(91)83029-K
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  • 2
    Electronic Resource
    Electronic Resource
    2H NMR determination of site-specific natural isotope fractionation in (-)-α-bisabolols
    Amsterdam : Elsevier
    Phytochemistry 31 (1992), S. 171-174 
    Details
    ISSN: 0031-9422
    Keywords: (-)-α-bisabolol ; Chamomilla recutita,Vanillosmopsis erythropappa ; Compositae ; adulteration of essential oils ; quantitative deuterium NMR spectroscopy ; site-specific natural isotope fractionation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0031-9422(91)83029-K
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluation of the clonidine-suppression test in the diagnosis of pheochromocytoma (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 764-767 
    Details
    ISSN: 1432-1440
    Keywords: Catecholamines ; Clonidine ; Pheochromocytoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study we examined the preoperative value of the clonidine-suppression test in 15 patients with surgically proved pheochromocytomas. The result of the clonidine-suppression test was pathological (epinephrine plus norepinephrine above 500 ng/l 3 h after clonidine) in 10 of 15 patients (66%). These patients had relatively large tumors and higher basal norepinephrine plasma levels. Out of the 5 cases without a pathological clonidine test 4 had normal basal plasma catecholamine levels with the result that the clonidine test could not be properly applied and 1 case produced a false negative result. These 5 cases generally had smaller tumors and lower plasma catecholamine levels. Two of these cases had basally raised epinephrine values. The other three cases had either a paradoxical increase or a suspiciously low fall (less than 25%) in norepinephrine within the normal range. We conclude that the clonidine-suppression test is only reliable for the diagnosis of relatively large pheochromocytomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726574
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  • 4
    Electronic Resource
    Electronic Resource
    Intraoperative localization of malignant pheochromocytoma by 123-i-metaiodobenzylguanidine single probe measurement (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 61-64 
    Details
    ISSN: 1432-1440
    Keywords: Pheochromocytoma ; MIBG scintigraphy ; Intraoperative staging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Metaiodobenzylguanidine (MIBG) imaging is a well-established method for locating intra-and extraadrenal pheochromocytomas. We investigated whether preoperative injection of 123-I-MIBG might be useful for intraoperative staging of chromaffine tumor cells. This was performed in a 46-year-old patient in whom the diagnosis of a malignant pheochromocytoma had been established by 123-I-MIBG imaging and enhanced catecholamine secretion. The rationale for intraoperative staging in this patient was a discrepancy between computed tomography (CI) of the abdomen and the radionuclide imaging, because scintigraphy revealed a mass with MIBG uptake in the right lower abdomen that could not be visualized by CT. We thus applied a preoperative dose of 4 mCi 123-I-MIBG and determined tissue activity by direct organ measurement. A right abdominal mass was thus identified with an activity of 10×104 impulses/s as compared to normal tissue (15×102). The left-sided tumor was found to be identified correctly by prior CT and MIBG imaging. We thus conclude that intraoperative application of this single probe measurement might help to identify chromaffine tumor cells that have not been located fully by CT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01713012
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison of131I-metaiodobenzylguanidine scintigraphy with urinary and plasma catecholamine determinations in the diagnosis of pheochromocytoma (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 627-630 
    Details
    ISSN: 1432-1440
    Keywords: Pheochromocytoma ; Catecholamines ; Scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a retrospective study of 31 patients with suspected pheochromocytoma we examined the preoperative results of131I-metaiodobenzylguanidine (131-I-MIBG) scintigraphy and a fluorimetric urine catecholamine determination test. An additional radioenzymatic plasma catecholamine determination test was performed in 25 patients. In 14 of the 31 patients the diagnosis of pheochromocytoma was later histologically confirmed. In the remaining 17 patients the suspected diagnosis was finally rejected after a clinical decision had been made on the basis of clinical history, symptoms, laboratory and imaging tests. 131-I-MIBG scintigraphy apparently had a very high specificity (no false-positive results among the patients with rejected diagnosis), but showed the least sensitivity (3 of 14 tumours were not detected). Urine cate-cholamines showed two false-negative and three false-positive results. Plasma catecholamines had the highest sensitivity and gave only one false-positive result. Because of its high pathognomonic value 131-MIBG scintigraphy can be helpful not only for localization, but also for confirmation of diagnosis when catecholamine determination tests are contradictory. On the basis of our experience with false-positive results after interfering medication therapy, urine and plasma catecholamine determination tests should only be carried out after purification with thin layer chromatography or high performance liquid chromatography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732857
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  • 6
    Electronic Resource
    Electronic Resource
    Saralasin-abhängige Änderungen von Blutdruck, Renin und Aldosteron bei essentieller und renininduzierter Hypertonie (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 859-864 
    Details
    ISSN: 1432-1440
    Keywords: Saralasin ; Angiotensin antagonist ; Hypertension ; Salt depletion ; Renin ; Aldosterone ; Saralasin ; Angiotensinantagonist ; Hochdruckdiagnostik ; Kochsalzverarmung ; Renin ; Aldosteron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Differenzierung zwischen essentieller und renininduzierter Hypertonie wurde bei 34 Patienten nach unterschiedlicher Kochsalzverarmung Saralasin infundiert. Nach kurzdauernder Kochsalzverarmung kam es bei 9 von 25 Patienten mit essentieller und bei 7 von 9 Patienten mit renininduzierter Hypertonie zu einem Abfall des arteriellen Mitteldruckes von mehr als 10 mm Hg. Nach langdauernder Kochsalzverarmung fiel der arterielle Mitteldruck unter Saralsin bei 11 von 16 Patienten mit essentieller und bei 8 von 9 Patienten mit renininduzierter Hypertonie um mehr als 10 mm Hg. Der Saralasin-Test erlaubte somit keine sichere Differenzierung zwischen beiden Hochdruckformen. Ebenso war durch die Plasma-Renin-Werte vor und nach Saralsin diese Differenzierung nicht möglich. Die Reninwerte unter Saralasin waren zur Blutdruckänderung negativ korreliert. Der Quotient der Reninkonzentration im Nierenvenenblut bei Patienten mit einseitiger Nierenarterienstenose wurde durch Saralasin nicht verändert. Plasmarenin und Plasmaaldosteron wurden durch Saralasin gegensinnig beeinflußt.
    Notes: Summary In 34 patients saralasin was infused after variable degrees of sodium depletion in order to differentiate between essential and renin-induced hypertension. After sodium-depletion of short duration mean arterial pressure dropped more than 10 mm Hg in 9 of 25 patients with essential and in 7 of 9 patients with renin-induced hypertension. After long-lasting sodium depletion the fall of mean arterial pressure exceeded 10 mm Hg in 11 of 16 patients with essential and in 8 of 9 patients with renin-induced hypertension. Thus saralasin did not discriminate essential and renin-induced hypertension. Also, plasma renin concentration before and after saralasin did not allow to differentiate between the two forms of hypertension. The change of renin during infusion of saralasin was negatively correlated to the change of blood pressure. Renal vein renin ratio in patients with renovascular hypertension was not modified by saralasin. Renin and aldosterone changed inversely during saralasin infusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01479836
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  • 7
    Electronic Resource
    Electronic Resource
    Hämodynamische Veränderungen nach Hemmung des Renin-Angiotensin-Systems durch Saralasin (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 647-649 
    Details
    ISSN: 1432-1440
    Keywords: Saralasin ; Angiotensin II inhibition ; Cardiac output ; Renin-angiotensin system ; Betablockade ; Saralasin ; Angiotensin II Hemmer ; Herzzeitvolumen ; Renin-Angiotensin-System ; Beta-Blocker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Infusion des Angiotensin II Inhibitors Saralasin bei 10 Hypertonikern führte nach Kochsalzverarmung zur Blutdrucksenkung, wobei eine reflektorische Steigerung von Herzfrequenz und Herzzeitvolumen ausblieben. Aus der fehlenden Kreislaufregulation nach Angiotensin II Hemmung wird auf einen unmittelbaren Einfluß von Angiotensin II auf die Barorezeptoren und/oder Katecholamine geschlossen. Das Ausbleiben der blutdrucksenkenden Wirkung von Saralasin nach vorheriger Gabe von Beta-Blockern stützt diese Hypothese.
    Notes: Summary Saralasin, an angiotensin II inhibitor was infused in 10 hypertensive patients. A blood pressure reduction was achieved after stimulation of the reninangiotensin-system by salt depletion. Heart rate and cardiac output failed to compensate for reduction of blood pressure. Thus circulatory reflex-mechanisms are inhibited by saralasin. A direct influence on baroreceptor mechanism and/or catecholamines is probable. Failure of the hypotensive effect of saralasin in salt-depleted patients after administration of betablockers supports this hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01482535
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