Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 21
    Electronic Resource
    Electronic Resource
    Penetration of ampicillin and sulbactam into human costal cartilage (1994)
    Springer
    Infection 22 (1994), S. 152-155 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Frage, ob Ampicillin und Sulbactam in ausreichendem Maße in den Rippenknorpel penetrieren, wurde bei 21 Kindern, welche sich einer operativen Trichterbrust-Korrektur unterziehen mußten, untersucht. Hierzu wurden die Konzentrationen der beiden Substanzen jeweils im äußeren und inneren Anteil von Knorpelproben gemessen, welche entweder ca. 45 min oder ca. 120 min nach intravenöser Gabe von Ampicillin/Sulbactam (Dosierung 33,3/16,7 mg/kg Körpergewicht) gewonnen wurden. Ampicillin wurde mittels Bioassay und Sulbactam mittels Gaschromatographie/Massenspectometrie bestimmt. Die mittleren Konzentrationen von Ampicillin im äußeren bzw. im inneren Probenanteil waren nach 45 min 23,3 mg/kg bzw. 10,4 mg/kg und nach 120 min 27,4 mg/kg bzw. 7,8 mg/kg. Die entsprechenden Werte für Sulbactam zu denselben Zeitpunkten waren 21,3 mg/kg bzw. 9,7 mg/kg und 17,5 mg/kg bzw. 11,9 mg/kg. Die gemessenen Werte zeigen, daß beide Substanzen hohe Konzentrationen auch in bradytrophen Geweben wie zum Beispiel Knorpel erreichen. Diese Konzentrationen übersteigen die MHK-Werte der bei postoperativen Wundinfektionen bedeutsamen Erreger. Sulbactam-geschütztes Ampicillin erscheint für die perioperative Prophylaxe bei thoraxchirurgischen Eingriffen gut geeignet.
    Notes: Abstract The question of whether ampicillin and sulbactam are able to penetrate sufficiently into costal cartilage tissue was investigated in 21 children undergoing surgery for funnel chest malformations. The concentrations of both compounds were determined in the core and mantle pieces of samples taken 45 min or 120 min after infusion of ampicillin/sulbactam (33.3/16.7 mg/kg bodyweight) preoperatively for antibiotic prophylaxis. Ampicillin was determined by bioassay and sulbactam was determined by gaschromatography/mass spectrometry. Mean concentrations of ampicillin were 23.3 mg/kg and 10.4 mg/kg at 45 min and at 27.4 mg/kg and 7.8 mg/kg 120 min in the mantle and core piece, respectively. Mean concentrations of sulbactam were at the same time 21.3 mg/kg and 9.7 mg/kg and 17.5 mg/kg and 11.9 mg/kg, respectively. These values indicate that both compounds achieve high concentrations even in bradytrophic tissue such as cartilage. The concentrations exceed the MIC values of important bacterial pathogens involved in postoperative wound infections. Therefore ampicillin protected by sulbactam appears to be a well-suited agent for perioperative prophylaxis in thoracic surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01739028
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 22
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of ampicillin, sulbactam and cefotiam in patients undergoing orthopedic surgery (1997)
    Springer
    Infection 25 (1997), S. 258-262 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary As perioperative prophylaxis for major orthopedic operations 81 patients were given the fixed combination of ampicillin (1 g)/ sulbactam (0.5 g) or cefotiam (2 g) as short infusions. The three β-lactams were rapidly distributed into the different tissues and their pharmacokinetic profiles were found to be very similar. It was noteworthy that ampicillin, sulbactam and cefotiam penetrated within minutes, not only into skin, fat and muscles, but also into bone. Thus 0.25 h after starting the infusion the following mean concentrations were measured in bone: 21.8±10.5 mg/kg ampicillin, 4.9±2.2 mg/kg sulbactam and 19.4±10.6 mg/kg cefotiam. For a period of at least 2 h the concentrations measured in serum and in the different tissues affected by the operation (skin, fat, muscle, bone) were above the MICs for pathogens which are involved in postoperative wound infections. On the basis of pharmacokinetic data, ampicillin/sulbactam and cefotiam seem about equally suitable for perioperative prophylaxis in major orthopedic operations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01713160
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 23
    Electronic Resource
    Electronic Resource
    Penetration of ampicillin and sulbactam into human epididymis and testis (1996)
    Springer
    Infection 24 (1996), S. 372-374 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Für urologische mikrochirurgische Refertilisationen wie die Vaso-Vasostomie oder die Vaso-Epididymostomie ist eine perioperative antibiotische Prophylaxe notwendig. Die Penetrationsfähigkeit in Nebenhoden- und Hodengewebe von Ampicillin und Sulbactam wurde bei neun Patienten (Körpergewicht 59 kg bis 92 kg, Mittel 77,3 kg) untersucht, die sich einer Orchiektomie aufgrund eines Hodenkarzinoms oder fortgeschrittenen Prostatakarzinoms unterziehen mußten. Die Konzentrationen beider Substanzen wurden im Serum und in Proben aus Nebenhoden/Hodengewebe, die 30 bis 65 Minuten nach einer einzelnen präoperativen Kurzinfusion von 3 g Ampicillin/Sulbactam im Verhältnis 2:1 gewonnen wurden, bestimmt. Ampicillin wurde mittels Bioassay und Sulbactam mittels Gaschromatographie/Massenspektrometrie bestimmt. Die mittlere Gewebekonzentration von Ampicillin betrug 38,5 ± 14,2 mg/kg. Die entsprechende mittlere Gewebekonzentration von Sulbactam betrug 19,8 ± 5,2 mg/kg. Ein Vergleich der Gewebe/Serum Quotienten für beide Substanzen ergab keine signifikanten Unterschiede. Die gemessenen Werte zeigen, daß beide Substanzen hohe Konzentrationen in den Skrotalorganen erreichen. Diese Konzentrationen übersteigen die MHK-Werte (minimalen Hemm-Konzentrationen) der bei postoperativen Wundinfektionen bedeutsamen Erreger. Die Kombination von Ampicillin und Sulbactam scheint für eine präoperative antibiotische Einzeldosisprophylaxe bei rekonstruktiven skrotalen Eingriffen gut geeignet.
    Notes: Summary Urologic refertilization microsurgery such as vaso-vasostomy or vaso-epididy-mostomy benefits from perioperative antibiotic prophylaxis. The ability of ampicillin and sulbactam to penetrate sufficiently into mixed epididymis or testis tissue was investigated in nine patients (bodyweights ranged from 58 kg to 92 kg, mean 77.3 kg) undergoing orchiectomy for testicular cancer or advanced prostatic cancer. Each patient received a single infusion of 3 g ampicillin/sulbactam (ratio 2 : 1) preoperatively for antibiotic prophylaxis. The concentrations of both components were determined in serum and in epididymis/testis tissue samples taken 30 min to 65 min after infusion. Ampicillin was determined by bioassay and sulbactam was determined by gas chromatography/mass spectrometry. Mean tissue concentrations of ampicillin were 38.5±15.9 mg/kg. Mean tissue concentrations of sulbactam at the same time were 19.8±5.2 mg/kg. Comparison of the tissue/serum ratios for both agents showed no significant difference. These values indicate that both compounds achieve high concentrations in the scrotal organs. The concentrations exceed the MIC (minimal inhibitory concentration) values of important bacterial pathogens such asStaphylococcus aureus involved in postoperative wound infections. The combination of ampicillin and sulbactam may be effective for perioperative prophylaxis in reconstructive scrotal urologic surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716082
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 24
    Electronic Resource
    Electronic Resource
    Effect of piroxicam on structure and function of joint cartilage (1984)
    Springer
    Inflammation 8 (1984), S. S139 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In vitro experiments were performed on isolated articular chondrocytes under the influence of piroxicam. It was demonstrated that this non-steroidal anti-inflammatory agent affected neither cell proliferation nor the incorporation of35SO4 into matrix macromolecules. Dogs were treated with piroxicam for 8 weeks. Morphological studies were performed on the tissues of the knee joints. Macroscopic and light microscopic investigations revealed no structural differences between the tissues (synovial membrane and articular cartilage) of control and treated dogs. Even at the ultrastructural level no alterations in the cartilage were observed. The capacity of chondrocytes to incorporate35SO4 under in vitro conditions was identical in control and experimental animals. It is concluded that piroxicam has no adverse effect on chondrocytes under in vitro conditions or on articular cartilage structure in the in vivo model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00915722
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 25
    Electronic Resource
    Electronic Resource
    Die Candida-Keratitis im Tierexperiment (1975)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 195 (1975), S. 251-262 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch Verwendung histologischer, immunhistologischer und elektronenmikroskopischer Methoden konnte gezeigt werden, daß die experimentelle Candida albicans-Keratitis der Maus in drei Phasen abläuft: auf eine traumatisch ausgelöste alterative folgt eine granulocytär-exsudative und schließlich eine proliferative Phase. Die Versuchsdauer betrug 41 Tage. Nur in den ersten 4 Tagen p.i. waren Pilzelemente nachweisbar. Eine zusätzlich zu der experimentellen Candidainfektion durchgeführte Tropfbehandlung der Hornhaut mit Hydrocortison führte zu einer geringeren sowie verzögerten Exsudation von Leukocyten und zu einer erheblich abgeschwächten Zellproliferation in dem geschädigten Hornhautstroma. Bei kombinierter Behandlung mit Hydrocortison und dem Antimykotikum Pimaricin war die Candidabesiedlung der Cornea deutlich geringer, am schwächsten jedoch waren Pilzwachstum und Entzündung bei alleiniger Behandlung mit Pimaricin.
    Notes: Summary Using histological, immunohistological and electron microscopical methods, it could be demonstrated that the course of experimental Candida albicans keratitis in mice involves three phases: a traumatically caused alterative phase is followed by a granulocytic exsudative phase and finally by a proliferative phase. The experiments were followed over 41 days. Fungal elements could be detected only during the first 4 days after infection. When topically treated with hydrocortisone, the exsudation of leucocytes was diminished and delayed and the cellular proliferation was reduced considerably in the challenged corneal stroma. A lower number of Candida organisms was found in the cornea when treatment with hydrocortisone was combined with the antifungal drug pimaricin. When treated with pimaricin only however, fungal growth and inflammation were least apparent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414938
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...