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  • 1
    Electronic Resource
    Electronic Resource
    Consequences of systemic venous drainage and denervation of heterotopic pancreatic transplants for insulin/C-peptide profiles in the basal state and after oral glucose (1991)
    Springer
    Diabetologia 34 (1991), S. S81 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas transplantation ; Insulin secretion ; C-peptide ; Systemic venous drainage ; Insulin metabolic clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma glucose, immunoreactive insulin and C-peptide concentrations were compared in nine pancreas-kidney-transplanted patients (systemic venous drainage) and in ten non-diabetic kidney-transplanted patients with similar kidney function. In the basal state, C-peptide (insulin secretion) was similar, but immunoreactive insulin was higher and glucose concentrations were slightly, but significantly lower in pancreas-transplanted patients. After 50 g oral glucose, the plasma glucose and IR-insulin profiles were similar in both groups. The circumvention of first-pass hepatic insulin extraction (decreased endogenous insulin clearance) was compensated for by a significant reduction in insulin secretion (C-peptide; p=0.036). In conclusion, hyperinsulinaemia in pancreas-transplanted patients with systemic venous drainage is significant only in the basal state. Insulin delivered into the portal and peripheral circulation, when leading to similar insulin profiles, maintains comparable degrees of glucose tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587626
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  • 2
    Electronic Resource
    Electronic Resource
    The bladder drainage technique in pancreas transplantation — the Tübingen experience (1991)
    Springer
    Diabetologia 34 (1991), S. S24 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas transplantation ; Bladder drainage technique ; Immunosuppression ; Complications ; Graft function rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Starting in 1987 renal- and pancreaticoduodenal — transplantations were performed simultaneously in a consecutive series of 40 patients with Type 1 diabetes mellitus and end-stage renal disease. Exocrine secretion of the pancreatic graft does not seem to be a crucial problem anymore when using the bladder drainage technique. No pancreatic fistulae were seen. No graft lost its function due to early post-operative graft thrombosis. Early post-operative graft pancreatitis and recurrent urinary tract infections remain the drawbacks of the bladder drainage technique. Despite a strong immunestimulation of the recipient by the combined pancreaticoduodenal/ renal allograft all but two rejection episodes could be reversed by using different monoclonal/ polyclonal antibodies. Actuarial 1-year-graft survival rate reaches 85 % for the pancreas as well as the kidney. Thus, simultaneous pancreas-kidney transplantation can be performed with a high success rate when using the technique described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587614
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  • 3
    Electronic Resource
    Electronic Resource
    Determinants of a normal (versus impaired) oral glucose tolerance after combined pancreas-kidney transplantation in IDDM patients (1996)
    Springer
    Diabetologia 39 (1996), S. 462-468 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas transplantation ; insulin secretion ; pancreatic hormones ; oral glucose tolerance ; glucagon stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After successful pancreas transplantation, insulin-dependent diabetic patients are characterized by a normal or at worst impaired oral glucose tolerance (World Health Organisation criteria). It is not known which pathophysiological mechanisms cause the difference between normal and impaired oral glucose tolerance. Therefore, we studied 41 patients after successful combined pancreas-kidney transplantation using stimulation in the fasting state with oral glucose (75 g), intravenous glucose (0.33 g/kg) and glucagon bolus injection (1 mg i.v.). Glucose (glucose oxidase), insulin and C-peptide (immunoassay) were measured. Repeated-measures analysis of variance and multiple regression analysis were used to analyse the results which showed: 28 patients had a normal, and 13 patients had an impaired oral glucose tolerance. Impaired oral glucose tolerance was associated with a greatly reduced early phase insulin secretory response (insulin p〈0.0001; C-peptide p=0.037). Age (p=0.65), body mass index (p=0.94), immunosuppressive therapy (cyclosporin A p=0.84; predniso(lo)ne p=0.91; azathioprine p=0.60) and additional clinical parameters were not different. Reduced insulin secretory responses in patients with impaired oral glucose tolerance were also found with intravenous glucose or glucagon stimulations. Exocrine secretion (α-amylase in 24-h urine collections) also demonstrated reduced pancreatic function in these patients (−46%; p=0.04). Multiple regression analysis showed a significant correlation of 120-min glucose with ischaemia time (p=0.003) and the number of HLA-DR mismatches (p=0.026), but not with HLA-AB-mismatches (p=0.084). In conclusion, the pathophysiological basis of impaired oral glucose tolerance after pancreas transplantation is a reduced insulin secretory capacity. Transplant damage is most likely caused by perioperative influences (ischaemia) and by the extent of rejection damage related, for example, to DR-mismatches.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400678
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  • 4
    Electronic Resource
    Electronic Resource
    Determinants of a normal (versus impaired) oral glucose tolerance after combined pancreas-kidney transplantation in IDDM patients (1996)
    Springer
    Diabetologia 39 (1996), S. 462-468 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Pancreas transplantation ; insulin secretion ; pancreatic hormones ; oral glucose tolerance ; glucagon stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After successful pancreas transplantation, insulin-dependent diabetic patients are characterized by a normal or at worst impaired oral glucose tolerance (World Health Organisation criteria). It is not known which pathophysiological mechanisms cause the difference between normal and impaired oral glucose tolerance. Therefore, we studied 41 patients after successful combined pancreas-kidney transplantation using stimulation in the fasting state with oral glucose (75 g), intravenous glucose (0.33 g/kg) and glucagon bolus injection (1 mg i. v.). Glucose (glucose oxidase), insulin and C-peptide (immunoassay) were measured. Repeated-measures analysis of variance and multiple regression analysis were used to analyse the results which showed: 28 patients had a normal, and 13 patients had an impaired oral glucose tolerance. Impaired oral glucose tolerance was associated with a greatly reduced early phase insulin secretory response (insulin p 〈 0.0001; C-peptide p = 0.037). Age (p = 0.65), body mass index (p = 0.94), immunosuppressive therapy (cyclosporin A p = 0.84; predniso(lo)ne p = 0.91; azathioprine p = 0.60) and additional clinical parameters were not different. Reduced insulin secretory responses in patients with impaired oral glucose tolerance were also found with intravenous glucose or glucagon stimulations. Exocrine secretion (α-amylase in 24-h urine collections) also demonstrated reduced pancreatic function in these patients (–46 %; p = 0.04). Multiple regression analysis showed a significant correlation of 120-min glucose with ischaemia time (p = 0.003) and the number of HLA-DR mismatches (p = 0.026), but not with HLA-AB-mismatches (p = 0.084). In conclusion, the pathophysiological basis of impaired oral glucose tolerance after pancreas transplantation is a reduced insulin secretory capacity. Transplant damage is most likely caused by perioperative influences (ischaemia) and by the extent of rejection damage related, for example, to DR-mismatches. [Diabetologia (1996) 39: 462–468]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400678
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  • 5
    Electronic Resource
    Electronic Resource
    Der Einfluß des Calciums auf den Serumgastrinspiegel und die Magensekretion beim Menschen (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 433-436 
    Details
    ISSN: 1432-1440
    Keywords: Gastrin ; gastric secretion ; calcium ; normal subjects ; duodenal ulcer ; Zollinger-Ellison syndrome ; Gastrin ; Magensekretion ; Calcium ; Normalpersonen ; Ulcus duodeni ; Zollinger-Ellison-Syndrom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß einer induzierten Hypercalcämie auf die Serumgastrinspiegel und die Magensekretion wurde bei Normalpersonen, Patienten mit Ulcus duodeni und Patienten mit Zollinger-Ellison-Syndrom untersucht. Bei allen Patientengruppen kommt es während der Calciumgluconatinfusion zu einem signifikanten Anstieg der Serumgastrinspiegel. Patienten mit Ulcus duodeni schütten jedoch 2–3mal soviel Gastrin während einer Hypercalcämie aus wie Normal-personen, während die Gastrinausschüttung bei Patienten mit Zollinger-Ellison-Syndrom ein Vielfaches der von Ulcus duodeni-Patienten beträgt. Die integrierte Säureausschüttung während Hypercalcämie ist bei Ulcus duodeni-Patienten ca. 5fach höher als bei Kontrollpersonen. Diese Untersuchungen zeigen, daß die Calcium-induzierte Magensekretion, zumindestens teilweise, durch eine Gastrinfreisetzung hervorgerufen wird.
    Notes: Summary We studied the effect of hypercalcemia on the serum gastrin concentration and gastric secretion in normal man, duodenal ulcer patients and patients with the Zollinger-Ellison syndrome. All subjects showed a significant increase of serum gastrin concentrations during calcium infusion. Patients with duodenal ulcer showed a 2- to 3-fold higher gastrin output during hypercalcemia than normal subjects, but the gastrin output in patients with Zollinger-Ellison syndrome was much higher compared to patients with duodenal ulcer. The integrated gastric secretory response to hypercalcemia is 5-fold higher in duodenal ulcer patients compared to normal subjects. These studies show that, at least in part, the calcium-induced gastric secretion is caused by gastrin release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468584
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  • 6
    Electronic Resource
    Electronic Resource
    Der Einfluß der Antrektomie oder der totalen Gastrektomie auf die calciuminduzierte Magensekretion und die Gastrinfreisetzung beim Menschen (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 1159-1163 
    Details
    ISSN: 1432-1440
    Keywords: Extragastric gastrin ; Calcium ; antrectomy ; Extragastrales Gastrin ; Calcium ; Antrektomie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 20 magengesunden Normalpersonen, 8 Patienten nach Antrektomie und Gastroduodenostomie (Billroth I), 12 Patienten nach Antrektomie und Gastrojejunostomie (Billroth II) sowie 9 Patienten nach totaler Gastrektomie und Ösophagojejunostomie untersuchten wird den Einfluß einer induzierten Hypercalcämie auf die Serumgastrinspiegel, gemessen mittels Radioimmunassay, und die Säuresekretion des Magens. Bei Normalpersonen stimuliert Calcium die Magensekretion und die Gastrinfreisetzung. Nach Antrektomie wird die Säuresekretion durch Calcium weiterhin stimuliert ohne deutliche Erhöhung der Serumgastrinspiegel. Nach totaler Gastrektomie fällt die basale Serumgastrinkonzentration weiter ab, Calcium bewirkt auch hier keine Freisetzung von Gastrin. Die hier erhobenen Befunde bestätigen früher geäußerte Vermutungen, daß die calciuminduzierte Säuresekretion neben einer Gastrinfreisetzung von Antrum vor allem durch direkte Einwirkung auf die Parietalzellen hervorgerufen wird. Intestinales Gastrin wird beim Menschen während der Hypercalcämie nicht freigesetzt.
    Notes: Summary The effect of induced hypercalcemia on serum gastrin concentrations, measured by radioimmunoassay, and gastric acid secretion was studied in 20 healthy subjects, 8 patients after antrectomy and gastroduodenostomy (Billroth I), 12 patients after antrectomy and gastrojejunostomy (Billroth II) and in 9 patients after total gastrectomy and esophagojejunostomy. In normal man calcium stimulates gastric secretion and gastrin release. After antrectomy gastric secretion is still stimulated by calcium without changing serum gastrin levels. After total gastrectomy basal serum gastrin concentration is further reduced; calcium does not liberate gastrin. These results show that calcium-induced gastric secretion is caused by direct action at the parietal cell level besides the gastrin release from the antrum. In man, extra antral gastrin cannot be released by induced hypercalcemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478053
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  • 7
    Electronic Resource
    Electronic Resource
    Iodine-induced thyrotoxicosis — A case for subtotal thyroidectomy in severely ill patients (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 1-7 
    Details
    ISSN: 1432-1440
    Keywords: Iodine-induced thyrotoxicosis ; Prognosis ; Therapy ; Subtotal thyroidectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Iodine-induced thyrotoxicosis (IIT), due to iodine application in high amounts in patients with circumscript or disseminated thyroid autonomy, is complicated by a prolonged course, mainly due on the body's resistance to conservative therapy with thiourea derivates. Therefore, we decided to perform subtotal thyroidectomy in 16 thyrotoxic patients. This is in contrast to the common opinion that surgery should only be performed after normalization of thyroid hormones. In all 16 patients with severe IIT, including three patients with thyroid storm, hormone levels decreased within a few days after surgery to normal or subnormal values and the clinical picture of thyrotoxicosis disappeared. In the case of thyroid storm the signs of disorientation normalized within 1–3 days. One patient died 5 weeks after surgery due to severe concomitant diseases. One patient exhibited transitory respiration distress and another had postoperative hypocalcaemia. In nine patients L-thyroxine replacement became necessary because of subclinical or clinical hypothyroidism. Only by this procedure will the high intrathyroidal storage of iodine and preformed hormone be extracted. Surgery as a treatment for thyrotoxicosis should be reserved for patients with severe IIT, where conservative treatment has been shown to be ineffective. Furthermore, in rare selected cases, when a rapid normalization is required, surgery without preoperative treatment seems to be justified. The effect of surgery was impressive in all our cases and there were only minor perioperative complications. Thus, it could be shown that subtotal thyroidectomy may be a rational and effective treatment in severe IIT which should be carefully considered and weighed against other types of therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537479
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  • 8
    Electronic Resource
    Electronic Resource
    Cholecystokinin Inhibits Food Intake at a Peripheral Extragastric Site (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 713 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb44118.x
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  • 9
    Electronic Resource
    Electronic Resource
    Comments on ''cis-trans photoisomerization of 1-(9-anthryl)-2-phenylethylenes: Effects of substitution and solvent polarity'' (H. Gorner, J. Photochem. Photobiol., A: Chem., 43 (1988) 263)
    Amsterdam : Elsevier
    Journal of Photochemistry and Photobiology A: Chemistry 43 (1988), S. 291-292 
    Details
    ISSN: 1010-6030
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/1010-6030(88)80025-X
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  • 10
    Electronic Resource
    Electronic Resource
    High-performance liquid chromatographic separation of biogenic polyamines using 2-(1-pyrenyl)ethyl chloroformate as a new fluorogenic derivatizing reagent
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 613 (1993), S. 15-21 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-4347(93)80192-7
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