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  • 1
    Electronic Resource
    Electronic Resource
    Die Rolle der Milz bei hämolytischen Erkrankungen (1969)
    Springer
    Annals of hematology 19 (1969), S. 99-113 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary On account of its anatomical structure and the related special circulatory dynamics the spleen basically has the ability for pooling and destruction of erythrocytes. These functions increase as the size of the organ increases and thus even normal erythrocytes are damaged mechanically and metabolically by prolonged and repeated pooling in the spleen. The cumulative effect may be a hemolytic anemia which is usally of a mild degree. Abnormal erythrocytes tolerate this stress uncomparatively worse. In these cases the spleen may become the cause of a severe hemolytic anemia. However, in the presence of erythrocyte damage which has already resulted in generalized intravascular hemolyses the hemolytic function of the spleen is of lesser importance simply on a quantitative basis.
    Notes: Zusammenfassung Auf Grund ihrer anatomischen Beschaffenheit und der damit verknüpften besonderen Kreislaufdynamik besitzt die Milz grundsätzlich die Fähigkeit zum “pooling” und zur Destruktion von Erythrozyten. Diese Funktionen nehmen mit der Vergrößerung des Organs zu, so daß selbst normale Erythrozyten durch verlängertes und wiederholtes “pooling” in der Milz mechanisch und metabolisch geschädigt werden und cumulativ eine, meist gering ausgeprägte, hämolytische Anämie entstehen kann. Abnormale Erythrozyten überstehen einen derartigen Stress ungleich schlechter. In diesen Fällen kann dann die Milz zur Ursache einer schweren hämolytischen Anämie werden. Liegen jedoch Erythrozytenschädigungen vor, die bereits zu generalisierten intravasalen Hämolysen führen, ist die hämolytische Funktion der Milz schon rein quantitativ von untergeordneter Bedeutung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01633091
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  • 2
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1964)
    Springer
    Journal of molecular medicine 42 (1964), S. 248-252 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487957
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  • 3
    Electronic Resource
    Electronic Resource
    Zur selektiven Darstellung von eosinophilen Granulocyten und ihren Vorstufen in Ausstrichen und Schnitten (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 191-192 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A selective staining method for eosinophils and their precursors in smears and paraffin sections is described. The reaction bases on tryptophane like substances within eosinophilic granules, which can be demonstrated by a modified p-dimethylaminobenzaldehyde-nitrite method after Adams. By this means eosinophilic granules are stained distinctively in a blue colour.
    Notes: Zusammenfassung Es wird eine Methode zur selektiven Anfärbung der Eosinophilen und ihrer Vorstufen in Paraffinschnitten und Ausstrichen beschrieben. Aufgrund des Reichtums der eosinophilen Granula an tryptophanhaltigen Substanzen gelingt es, sie mit Hilfe von p-Dimethylaminobenzaldehyd-Nitrit nach Adams darzustellen. Die eosinophilen Gra nula erscheinen dabei distinkt blau gefärbt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01584574
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  • 4
    Electronic Resource
    Electronic Resource
    Autopsy findings in AIDS — A histopathological analysis of fifty cases (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 654-663 
    Details
    ISSN: 1432-1440
    Keywords: AIDS ; Autopsy ; Histopathology ; HIV ; Opportunistic infections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty consecutive AIDS autopsy cases were evaluated. All subjects showed one or more opportunistic infections and malignancies included in the AIDS case definition with cytomegalovirus and Kaposi's sarcoma being most prevalent. Mycobacterial and cryptococcal infections occurred only infrequently. Most patients of our series after successful treatment ofPneumocystis carinii pneumonia or cerebral toxoplasmosis later succumbed to less treatable conditions like disseminated cytomegalovirus or fungal infections or malignant lymphoma. In the absence of specific treatment for the HIV infection leading to these lethal complications special emphasis must be put on the prevention of HIV transmission and spread.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01875500
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  • 5
    Electronic Resource
    Electronic Resource
    Zur Cytologie und Fermenteytochemie der menschlichen Milz (1967)
    Springer
    Journal of molecular medicine 45 (1967), S. 210-217 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A cytological and enzyme cytochemical (α-naphthyl-acetate-esterase, naphthol-AS-acetate-esterase, naphthol-AS-D-chloroacetate-esterase, acid and alkaline phosphatase) analysis of human spleen cells in smear preparations was performed with special reference to littoral cells of splenic sinuses. These littoral cells show strong naphthol-AS-acetate-esterase and none or little α-naphthyl-acetate-esterase activity. Thus they can be differentiated from reticular cells and other cellular elements to be found in splenic smears. Morphology and enzyme cytochemistry of littoral cells render them to be a distinct cell type of human spleen.
    Notes: Zusammenfassung In Ausstrichpräparaten menschlicher Milzen wurden cytologische und fermentcytochemische Untersuchungen (α-Naphthyl-acetat-Esterase, Naphthol-AS-acetat-Esterase, Naphthol-AS-D-Chlor-acetat-Esterase, saure Phosphatase und alkalische Phosphatase) durchgeführt. Dabei wurde besonders das Verhalten der Sinuswandzellen beobachtet. Es gelang, morphologische und enzymcytochemische Kriterien aufzuzeigen, aus denen ersichtlich ist, daß die Sinuswandzellen weder mit den Reticulumzellen noch mit anderen im Milzausstrich anzutreffenden Zellen identisch sind, sondern eine besondere, für die menschliche Milz sehr typische Zellform darstellen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716910
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  • 6
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1967)
    Springer
    Journal of molecular medicine 45 (1967), S. 166-167 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01725078
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  • 7
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1965)
    Springer
    Journal of molecular medicine 43 (1965), S. 962-964 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712074
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  • 8
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1966)
    Springer
    Journal of molecular medicine 44 (1966), S. 1103-1104 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716317
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  • 9
    Electronic Resource
    Electronic Resource
    Hamartomas of the spleen: a study of 20 biopsy cases (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 14 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty hamartomas of the spleen were studied by histological, immuno- and enzyme-histochemical methods. In all cases nodules of varying size resembling proliferation of splenic red pulp structures were present that exhibited considerable morphological variation with regard to plasmacytosis, extramedullary haematopoiesis and phagocytic activity of macrophages. Splenic red pulp structures could be identified by immuno- and enzyme-histochemical markers reacting with sinus endothelium, including Factor VIII related antigen, proteinase inhibitors and nonspecific esterases. In conjunction with the absence of organized lymphoid tissue and of dendritic reticulum cells these studies allow the differentiation of splenic hamartomas from haemangiomas that may possess a deceptively similar morphological appearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb02201.x
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  • 10
    Electronic Resource
    Electronic Resource
    The spleen in Hodgkin's disease. An immunohistochemical study of lymphocyte subpopulations and macrophages (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 13 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lymphocyte subpopulations and macrophages in 16 spleens from patients with Hodgkin's disease were analysed immunohistochemically using monoclonal antibodies of the Leu and the Ki M series. In non-involved splenic tissue there is an increase of T-lymphocytes with an increased T-helper/T-suppressor cell ratio, while Ki M-1, -2, -3 and -5-positive, i.e. phenotypically different macrophages, are reduced. These results indicate that involvement of the spleen in Hodgkin's disease is accompanied by changes with respect not only to lymphocyte subpopulations but also to cells of the mononuclear phagocyte system. The immunodeficiency associated with Hodgkin's disease is probably not solely due to lymphocyte dysfunction, since the disease may lead, at least in the spleen, to alterations in macrophages and accessory cells and this may contribute to the impairment of cell-mediated immunity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb02019.x
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