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  • 1
    Electronic Resource
    Electronic Resource
    STUDIES ON FORMATION OF γ-GLUTAMYLAMINES IN RAT BRAIN AND THEIR SYNTHETIC AND CATABOLIC ENZYMES (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 29 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: γ-Glutamylation of p-tyramine, noradrenaline, dopamine and serotonin in rat brains was demonstrated by intraventricular injections of the radioactive amines and isolation of the γ-glutamylamines from the acidic extract of the rat brains. Formation of these γ-glutamylamines was proved to be catalysed by γ-glutamyltranspeptidase prepared from both rat kidney and brain. However, these compounds were degraded by γ-glutamylcyclotransferase of rat brain, but not by the emzyme of rat kidney.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb07779.x
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  • 2
    Electronic Resource
    Electronic Resource
    METHYLATED AMINO ACID RESIDUES OF PROTEINS OF BRAIN AND OTHER ORGANS (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 24 (1975), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —Methods for the determination of methyl-lysine, methyllarginine and methylhistidine residues of tissue proteins are described. They consist of preliminary purification of basic amino acids, enzymic removal of lysine, arginine and histidine followed by amino acid analysis. Recovery rates and specificities of the method were satisfactory. The contents of methylamino acids in proteins of mammalian organs were determined.The distribution of proteins containing the methylamino acids in human brain showed that the concentrations of methyl-lysine and NG,N′G-dimethylarginine were highest in the gray matter of the cerebellar cortex and relatively high in regions rich in gray matter, while those of NG-mono- and NG,N′G-dimethylarginine were highest in the white matter. The following findings suggest that most of the NG-mono- and NG,N′G-dimethylarginine was associated with the myelin basic protein. The distribution of the methylarginine residues of acid-soluble proteins in bovine brains coincided with the cerebroside pattern. The concentrations of the amino acids in acid-soluble proteins of rat brain increased concomitantly with the increase of cerebroside. The methylamino acid content in proteins increased during the purification of the myelin basic protein from the white matter of human and bovine brains.Proteins containing NG,NG-dimethyiarginine and di- and trimethyl-lysine are concentrated in cell nuclei. The first amino acid was found mainly in nucleoplasmic proteins and the other two were found in histones. The concentration of 3-methylhistidine residue, highest in muscular proteins, is low in cerebral proteins and is probably derived from proteins of walls of blood vessels in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1975.tb03653.x
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of carbonic anhydrase III and muscle-specific enolase in paraffin-embedded human skeletal muscle sections (1985)
    Springer
    Acta neuropathologica 68 (1985), S. 74-76 
    Details
    ISSN: 1432-0533
    Keywords: Muscle ; Carbonic anhydrase ; Enolase (phosphopyruvate hydratase) ; Paraffin ; Histocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have demonstrated the histochemical fiber types of human skeletal muscle in paraffin sections by the immunohistochemical method, together with compatible observations previously made in frozen sections that carbonic anhydrase III is mainly localized in type 1 fibers (Shima et al. 1983), and muscle-specific enolase in type 2 fibers (Ibi et al. 1983). This method is useful to analyze the fiber types when frozen muscle samples at biopsy or autopsy cannot be obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688959
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  • 4
    Electronic Resource
    Electronic Resource
    High-resolution MR imaging evaluation of hepatocellular carcinoma (1997)
    Springer
    Abdominal imaging 22 (1997), S. 182 -186 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Liver MR—Liver neoplasms—Magnetic resonance (MR), rapid imaging—Magnetic resonance (MR), high-resolution imaging.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Purpose: To determine the utility of high-resolution MR imaging for hepatocellular carcinoma. Materials and methods: High-resolution MR images with a 512 matrix in a right to left frequency encoding direction were obtained in 20 consecutive patients with known or suspected hepatocellular carcinoma (HCC). Six series of breath-hold images of the entire liver [T1- and T2-weighted fast spin echo sequences, T1-weighted fast low-angle shot gradient echo sequence and three-phased contrast-enhanced dynamic study using the latter) were obtained using a phased-array multicoil. Results: HCC was depicted in 15 patients on the MR images, and the diagnosis was confirmed at pathology in 13 and at imaging in the other two. In the remaining five patients, HCC was correctly ruled out with MR imaging. Conclusion: High-resolution MR imaging is a promising method in the evaluation of HCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900168
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  • 5
    Electronic Resource
    Electronic Resource
    Infected abdominal aortic aneurysm: early CT findings (1998)
    Springer
    Abdominal imaging 23 (1998), S. 645-648 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Aorta, abdominal—Aneurysm, infected—Early stage—Computed tomography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We describe computed tomographic (CT) findings at the early stage of infected abdominal aortic aneurysm in three patients. Periaortic mass and increased fat density were the characteristic findings of early aortic infection on CT. Similar findings caused by other diseases may be difficult to differentiate by imaging alone, but these findings should be used to trigger close follow-up for patients with suspected infected abdominal aortic aneurysm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900422
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  • 6
    Electronic Resource
    Electronic Resource
    Pseudotumorous enlargement of the paracaval portion of the caudate lobe: a report of two cases with CT and MR appearance (1997)
    Springer
    Abdominal imaging 22 (1997), S. 398 -400 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Liver, CT—Liver, magnetic resonance—Liver, caudate lobe—Caudate lobe, paracaval portion.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The computed tomographic (CT) and magnetic resonance appearance of pseudotumorous enlargement of the paracaval portion (PCP) of the caudate lobe of the liver are presented in two cirrhotic patients. The enlarged PCP was hyperattenuated on precontrast CT and hyperintense on T1-weighted images. The middle and right hepatic veins were displaced around the PCP. The presence of a portal vein branch penetrating the center of the enlarged PCP was important to distinguish it from other hepatic masses in the two patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900219
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  • 7
    Electronic Resource
    Electronic Resource
    Plasma and right auricle concentrations of atrial natriuretic polypeptide in children with cardiac diseases (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 485-489 
    Details
    ISSN: 1432-1076
    Keywords: Atrial natriuretic polypeptide ; Cardiac disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate the atrial natriuretic polypeptide (ANP) levels in congenital heart diseases, we measured plasma immunoreactive ANP (ir-ANP) in 29 patients with left-to-righ shunt, and right auricle ir-ANP in 25 patients who underwent operation. The levels of ir-ANP in the pulmonary artery correlated with that in the femoral vein (r=0.95, P〈0.001), mean pulmonary arterial pressure (r=0.74, P〈0.001) and right atrial pressure (r=0.53, P〈0.01). The right auricle ir-ANP level was high in patients with heart failure combined with pressure or volume overload of the right atrium, as observed in tricuspid atresia, complete endocardial cushion defect, and total anomalous pulmonary venous drainage. These results suggest that the production of ANP in the atrium increases as a compensatory or secondary response to persistent release of ANP into the circulation in cardiac diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441972
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  • 8
    Electronic Resource
    Electronic Resource
    Pseudomyxoma retroperitonei (1999)
    Springer
    European radiology 9 (1999), S. 457-459 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Retroperitoneal neoplasms ; Retroperitoneal space ; Computed tomography ; Magnetic resonance imaging ; Ultrasonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We report a rare case of pseudomyxoma retroperitonei in a 58-year-old woman with a past history of severe appendicitis. The imaging showed a multicystic mass similar to pseudomyxoma peritonei, but the tumor was located in the retroperitoneal space.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050692
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  • 9
    Electronic Resource
    Electronic Resource
    Late-onset acid maltase deficiency associated with intracranial aneurysm (1988)
    Springer
    Journal of neurology 235 (1988), S. 371-373 
    Details
    ISSN: 1432-1459
    Keywords: Acid maltase deficiency ; Aneurysm ; Smooth muscle cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The autopsy findings in a patient with late-onset acid maltase deficiency who died following rupture of a basilar artery aneurysm are reported. The patient developed muscular weakness and wasting at the age of 20 years and died 9 years later after suddenly falling into a coma. At autopsy a giant fusiform aneurysm was found in the basilar artery which had ruptured at the base of the pons, leading to a large haematoma in the pons. The cerebral arteries and arterioles showed extensive vacuolar degeneration of smooth muscle cells in the media. It is suggested that the aneurysm was induced by fragility of the arterial wall due to this smooth muscle change.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314237
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  • 10
    Electronic Resource
    Electronic Resource
    Anti-transfer RNA antibodies in two patients with pulmonary fibrosis, Raynaud's phenomenon and polyarthritis (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 144-147 
    Details
    ISSN: 1434-9949
    Keywords: Autoantibody ; Interstitial pulmonary fibrosis ; Polyarthritis ; Raynaud's phenomenon ; Transfer RNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patient W.S. (a 61-year-old woman) and patient T.M. (a 41-year-old man) developed recurrent fevers, polyarthritis, Raynaud's phenomenon and interstitial pulmonary fibrosis without apparent polymyositis. From HeLa cell extracts, sera from both patients immunoprecipitated all species of intact and deproteinised tRNAs. To identify the antibody binding site more precisely, tRNAs transcribed in vitro from clonedEscherichia coli tRNA genes and various mutants were prepared and used as antigens for immunoprecipitation. When the TψC loop, or the D loop were deleted, such mutants were not bound by both sera, suggesting that the D and TψC loops were required for antibody binding. Abrogation of tRNA binding occurred when18G of tRNATrp was replaced with18A to break the tertiary L-shape structure of tRNA. These results strongly suggest that sera from W.S. and T.M. recognise the tertiary conformation of L-shaped tRNA which is constructed with both D and TψC loops. These autoantibodies may also serve as a marker for a new subset of patients with connective tissue diseases that is distinct from anti-aminoacyl-tRNA synthetase syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01452262
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