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  • 1
    Electronic Resource
    Electronic Resource
    CGS 26529: The biological profile of a novel, orally active 5-lipoxygenase inhibitor with an extended duration of action (1995)
    Springer
    Inflammation research 44 (1995), S. S147 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01778305
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Electrophysiological brainstem investigations in obstructive sleep apnoea syndrome (1996)
    Springer
    Journal of neurology 243 (1996), S. 171-174 
    Details
    ISSN: 1432-1459
    Keywords: Brainstem function ; Obstructive sleep apnoea ; Brainstem lesion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phasic inspiratory genioglossus activity prevents pharyngeal airway collapse in healthy subjects during sleep and is diminished or absent in obstructive sleep apnoea syndrome (OSAS), thus leading to pharyngeal obstruction. Case reports of OSAS after pontomedullary lesions indicate that impaired inspiratory genioglossal activity may result from brainstem lesions. We therefore investigated brainstem functions in 18 awake patients with OSAS using brainstem auditory evoked potentials, blink reflex, masseter reflex, masseter inhibitory reflex (in 11 of 18 patients), magnetic evoked potentials of the tongue and electrooculography with vestibular testing. Fifteen of 18 patients showed no electrophysiological abnormalities. One patient had a left pontine and two patients a bilateral pontomesencephalic lesion, although a causal connection with OSAS was not conclusively confirmed. Our results do not support the assumption of a relevant structural brainstem lesion in OSAS patients with normal neurological findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02444011
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  • 3
    Electronic Resource
    Electronic Resource
    Microsystems for independent parallel chemical and biological processing (1995)
    Springer
    Microsystem technologies 1 (1995), S. 168-172 
    Details
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Notes: Abstract Modern microsystem application is concentrated on the development of microstructured sensors and actuators in integrated devices. Examples of that approach are microoptical components for endoscopic surgery, sensors and micropumps in integrated liquid analysers for pollution measurements. Often microsystems replace normal systems like commercially available piston pumps by silicon made liquid pumps in the hope of reducing costs but there is a lack of finding new applications. In contrast our approach of combining special developed microcompartments constructed with transparent membranes or microsieves and microdosing systems based on the ink jet principle together with optical devices like CCD cameras allow to overcome a real bottleneck in the new field of evolutionary biotechnology, the problem of screening a huge number of samples at a reasonable price. The goal of this approach is to design new molecules like enzymes by means of Darwinian evolution i.e. mutation and selection. In applying the selection principle to self amplifying entities like cell populations, viruses or self-replicating molecules under controlled selection pressures there is an absolute need to process large numbers of these entities in parallel. Preferentially this can be done in arrays of different microstructured compartments. The selection process is designed that it leads to products which are optimized in regard of specific applications. Within the scope of this approach chemical products are deterministically synthesized in spatially adressable compartments by multihead microdrop systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01371490
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  • 4
    Electronic Resource
    Electronic Resource
    Micromechanical elements for detection of molecules and molecular design (1995)
    Springer
    Microsystem technologies 1 (1995), S. 202-208 
    Details
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Notes: Abstract Photolithographic preparation of thin films and stacks of them were combined with anisotropic silicon etching and free standing film technology in order to realize three dimensional micro components for studies in detection and optimization of biomolecules. A polymer based SFM sensor was developed and tested in the measurement of thin film roughness and in the detection of holes in molecular films as well as in the detection of single DNA molecules. This “novolever” shows surprisingly high mechanical stability and provides high resolution SFM images of sensible molecules. Experimental arrangements of miniaturized chemical parallel processing for combinatorial and evolutionary synthesis strategies including silicon micro compartment arrays with free standing optical membranes and thin film filters have been proposed and the manufacturing of micro compartment arrays is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01371496
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  • 5
    Electronic Resource
    Electronic Resource
    Systemintegration of microsystems/chip elements in miniaturized automata for high-throughput synthesis and screening in biology, biochemistry and chemistry (1997)
    Springer
    Microsystem technologies 4 (1997), S. 35-39 
    Details
    ISSN: 1432-1858
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Technology
    Notes: Abstract  Microsystems recently have been introduced as tools for screening in modern chemistry, biochemistry and biology. It has been shown that new microsystems can be implemented in the biomedical laboratory by using the microsystemic approach for the sample carrier – the miniaturized microtiter plate (“the nanotiter plate”) – or the production of nanodroplets with ink jetters and to integrate those systems in macrodevices like xyz tables and detection devices like CCD-cameras. We show in this paper that decisive problems of the approach – the evaporation problem and the problem of chemical/biochemical/biological compatibility of the assays and the used materials can be solved successfully. It is possible to realize chemical synthesis in miniaturized flow systems and to perform isothermal amplification of RNA in silicon wafers. Furthermore real high throughput screening with in vivo systems can be performed and all relevant parameters as evaporation, pipetting and detection can be controlled on reasonable time scales.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005420050089
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Evaluation of instationary flow fields using crosscorrelation in image sequences (1996)
    Springer
    Experiments in fluids 20 (1996), S. 210-217 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In order to investigate the temporal behavior of dynamic flow processes, a movie version of particle image velocimetry (PIV) with a high framing capability has been developed. The experimental setup includes a copper vapor laser capable to produce pulse sequences with more than 100 pulses with a repetition rate of up to 30 kHz and a rotating drum camera to record the Mie scattering signals from the particles seeded to the flow. With this setup, image sequences with a number of consecutive images (40–70 depending on the image size) of a dynamic process can be taken on high resolution 36 mm film. To evaluate the 2-dimensional velocity vector fields, an algorithm based on the crosscorrelation of subareas in consecutive images has been developed and optimized in terms of computing time. The technique was applied to resolve the instationary flow field in a single cylinder spark ignition (SI) engine during the compression stroke.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190276
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  • 7
    Electronic Resource
    Electronic Resource
    Flow angle dependence for the asymmetry of broad 50-MHz coherent echoes at large magnetic aspect angles (1997)
    Springer
    Annales geophysicae 15 (1997), S. 671-684 
    Details
    ISSN: 0992-7689
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The skewness of broad Type 2-like spectra has been studied using data collected by two orthogonal CW 50-MHz radio links with co-located scattering volumes. Geometrical aspect angles of observations were about 10. One short event was considered. For this event, the electron flow direction was changing periodically (period about 9 minutes) presumably due to the passage of a magnetospheric MHD wave through the ionosphere. It was found that for the radar observations along the electrojet flow, the skewness had the same sign as the mean Doppler shift with average absolute values in between 0.5–1.0. For observations perpendicular to the electrojet flow, spectra were more symmetrical (average skewness was around 0) and the sign of the skewness was sometimes opposite to the sign of the mean Doppler shift. These observations are interpreted in terms of contribution from both the Farley-Buneman and gradient-drift instabilities to the resultant spectrum. Differences with radar observations at small aspect angles are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-997-0760-4
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  • 8
    Electronic Resource
    Electronic Resource
    Trivalent Cationic Conduction Properties in M〈sub〉2〈/sub〉(WO〈sub〉4〈/sub〉)〈sub〉3〈/sub〉-Al〈sub〉2〈/sub〉O〈sub〉3〈/sub〉 (M=Al, Sc, Lu) Composites (1999)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 315-317 (July 1999), p. 537-544 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/04/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.315-317.537.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Single-molecule fluorescence autocorrelation experiments on pentacene: The dependence of intersystem crossing on isotopic composition (1999)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 110 (1999), S. 9151-9159 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Single pentacene molecules containing 13C or 1H in a pentacene-d14 doped p-terphenyl crystal have been studied by fluorescence autocorrelation. The triplet dynamics has been analyzed and a systematic dependence of the S1→T1 intersystem crossing rate on isotopic composition was found. This variation is discussed in terms of a modulation of the near resonance of the first excited singlet state S1 and vibrational levels of an intermediating triplet state T3 which results from the distinct isotope dependence of the zero-point energy of both electronic states. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.478837
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  • 10
    Electronic Resource
    Electronic Resource
    13C isotope effects for pentacene in p-terphenyl: High-resolution spectroscopy and single-spin detection (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 2212-2222 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Weak satellites in S1←S0 excitation spectra of natural-abundance pentacene in p-terphenyl due to position-specific 13C isotope shifts were observed. An assignment of these satellites to the various carbon positions is derived. The extremely narrow inhomogeneous linewidth allowed selective excitation of pentacene molecules with 13C in specific positions. Spectra of the magnetic-resonance transition between triplet sublevels of such ensembles, and of individual pentacene molecules showed position-specific 13C hyperfine broadening. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.472116
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