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  • 1
    Electronic Resource
    Electronic Resource
    Stereochemistry of the isoprenylation of tryptophan catalyzed by 4-(.gamma.,.gamma.-dimethylallyl)tryptophan synthase from Claviceps, the first pathway-specific enzyme in ergot alkaloid biosynthesis (1990)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 112 (1990), S. 297-304 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00157a046
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  • 2
    Electronic Resource
    Electronic Resource
    Purification of Raw Materials for Fluoride Glass Fibers by Solvent Extraction (1991)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 32-33 (Jan. 1991), p. 75-80 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/04/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.32-33.75.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Membranous lipodystrophy (Nasu-Hakola disease) with thalamic degeneration: report of an autopsied case (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 414-419 
    Details
    ISSN: 1432-0533
    Keywords: Membranous lipodystrophy ; Thalamic degeneration ; Neuropathology ; Autopsy ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsied case of membranous lipodystrophy (Nasu-Hakola disease, NHD) with thalamic degeneration was reported. A 34-year-old Japanese man was diagnosed as having NHD by bone biopsy prior to the onset of clinical symptoms. His maternal grandfather and paternal grandmother are cousins, but this family history is negative for NHD. He developed frontal lobe syndrome at the age of 35 with progressive dementia, and died of acute renal failure at the age of 46. Gross inspection of the brain detected atrophy and softening of the cerebral white matter, predominantly in the frontal lobe. Microscopically, numerous spheroids, predominant fibrillary gliosis with less prominent demyelination “dissociation glio-myélinique” and scanty sudanophilic lipid droplets were observed, indicating the sclerosing type of NHD. An unusual pathological finding in this case was selective involvement of the thalamic nuclei with preservation of the other gray matter except for focal cortical necrosis. The topography of the affected thalamic nuclei is similar to that of systemic thalamus degeneration. An association with thalamic degeneration in NHD has not been previously reported. The present case suggests that NHD also affects the thalamus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296554
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  • 4
    Electronic Resource
    Electronic Resource
    Ambulatory blood pressure monitoring in elderly hypertensives treated with the new calcium antagonist, nilvadipine (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 255-257 
    Details
    ISSN: 1432-1041
    Keywords: Nilvadipine ; Hypertension ; elderly patient ; circadian rhythm ; ambulatory blood pressure monitoring (ABPM) ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary. A newly developed calcium antagonist, nilvadipine, was administered to 7 hypertensive patients aged 75.6 y. Nilvadipine 4 mg b.d. decreased the average 24-h blood pressure significantly from 169/89 mm Hg to 152/81 mm Hg after 7 to 14 days without any change in the pulse rate. The circadian patterns of blood pressure and pulse rate were not affected by nilvadipine. Although the present study was a preliminary one done over a short period in a small number of patients, the results suggest that nilvadipine exerts an antihypertensive effect without altering the circadian pattern or the variability of blood pressure in elderly hypertensive patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315439
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of nicardipine on haemodynamic response to stress in hypertension (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 265-269 
    Details
    ISSN: 1432-1041
    Keywords: Nicardipine ; Hypertension ; calcium antagonist ; mental arithmetic ; cold pressor test ; exercise test ; haemodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of the calcium antagonist nicardipine on the pressor response to mental arithmetic, cold pressor and exercise tests have been studied in fifteen patients with established mild to moderate essential hypertension. Nicardipine 20 mg p.o. showed a hypotensive effect within 60 min, associated with a fall in total peripheral resistance and an increase in heart rate. As the pressor response to each stress was not affected by nicardipine, the peak blood pressure reached during each stress was lower. Nicardipine lowers blood pressure at rest as a result of arteriolar dilatation, associated with reflex tachycardia. The pressor responsiveness to various stresses was not affected by nicardipine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266346
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of SUN 1165, a new antiarrhythmic agent, in renal dysfunction (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 411-414 
    Details
    ISSN: 1432-1041
    Keywords: SUN 1165 ; renal failure ; antiarrhythmic agent ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a new Class I antiarrhythmic agent, SUN 1165, has been studied in 32 patients with varying degrees of renal impairment following a single oral dose of 50 mg. The apparent volume of distribution at steady state was 1.48 1 · kg−1, the absorption rate constant was 2.2 h−1, and plasma protein binding was 26.8% in subjects with normal renal function. These variables were not altered with renal impairment. More than 60% of SUN 1165 given orally was excreted unchanged via the kidney, both by tubular secretion and glomerular filtration. The elimination rate constant, the apparent total body clearance and the apparent renal clearance were linearly correlated with the endogenous creatinine clearance. The half-time of elimination was 3.4 h in normal subjects and it was prolonged to 23.7 h in severe renal failure (creatinine clearance below 20 ml · min−1 · 1.48 m−2). Dosage adjustment of SUN 1165 is necessary in renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265853
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  • 7
    Electronic Resource
    Electronic Resource
    Elevated plasma nilvadipine concentration after single and chronic oral administration to patients with chronic liver disease (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 475-479 
    Details
    ISSN: 1432-1041
    Keywords: Calcium channel blocker ; Nilvadipine ; blood pressure ; liver disease ; pharmacokinetics ; pharmacodynamics ; cirrhosis ; hepatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fourteen normotensive patients with liver disease (6 with cirrhosis and 8 with chronic hepatitis) and 7 healthy volunteers were given a single oral dose of nilvadipine 2 mg. In addition, nilvadipine 4 mg was administered orally twice daily for several months to 6 hypertensive patients with mild liver dysfunction and 18 hypertensives with normal liver function. A significant increase in plasma nilvadipine was found in the patients with cirrhosis as compared both to the normal and chronic hepatitis subjects; the time to peak concentration was similar among the three groups. The peak plasma nilvadipine concentration was closely correlated both with the serum albumin level and the retention of indocyanine green. Changes in blood pressure, pulse rate and various vasoactive hormones following a single oral dose of nilvadipine did not differ between the groups. Thus, an increase in plasma nilvadipine relative to the level in normal subjects was demonstrated in patients with cirrhosis following a single oral dose, as well as in patients with slight liver dysfunction following long-term oral administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314853
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  • 8
    Electronic Resource
    Electronic Resource
    Renal effects of manidipine hydrochloride (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 321-325 
    Details
    ISSN: 1432-1041
    Keywords: Manidipine ; Essential hypertension ; renal function ; glomerular hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The renal effects of manidipine hydrochloride were investigated in ten hospitalised patients with mild-to-moderate essential hypertension. After a one-week placebo period, manidipine was given for 1 week in a dose rising from 5 mg to 10 mg or 20 mg daily to normalise the mean blood pressure measured after 2 h. Blood pressure had decreased from 171/101 to 147/86 mm Hg at the end of manidipine treatment. The pulse rate was unaltered. Renal vascular resistance decreased from 1.90 to 1.33 dyn · s · cm−5/1.48 m2 × 104, and renal blood flow and glomerular filtration rate increased from 522 to 662 ml · min−1 · 1.48 m−2 and from 81 to 93 ml · min−1 · 1.48 m−2, respectively, in spite of a fall in renal perfusion pressure. Manidipine reduced the filtration fraction from 0.260 to 0.243, suggesting a preferential reduction in efferent arteriolar resistance. The fractional excretion of sodium and potassium did not change. Manidipine did not produce any significant alteration in plasma renin activity or in the plasma aldosterone concentration. The results indicate that manidipine has favourable renal effects and a concomitant hypotensive action in patients with mild-to-moderate essential hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265948
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  • 9
    Electronic Resource
    Electronic Resource
    Development and preliminary application of a simple assay of S-mephenytoin 4-hydroxylase activity in human liver microsomes (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 559-562 
    Details
    ISSN: 1432-1041
    Keywords: S-mephenytoin 4-hydroxylase ; HPLC assay ; Human liver microsomes ; pharmacogenetics ; oxidation polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have developed a simple HPLC assay to measure the activity of S-mephenytoin 4-hydroxylase in human liver microsomes, and have assessed its practical applicability by determining the kinetic parameters of the enzyme in 10 different human liver samples. The recovery of 4-hydroxymephenytoin and phenobarbital (the internal standard) after the precipitation of microsomal protein was almost complete, and the coefficients of variation for the intra-and interassay measurement of S-mephenytoin 4-hydroxylase activity were 〈6.4 and 8.0%, respectively. Eadie-Hofstee plots for the formation of 4-hydroxymephenytoin gave a straight line for all of the 10 samples studied. There was large interindividual variability in the kinetic parameters estimated: 4.6- (36 to 166 μM), 11.8- (0.9 to 10.6 nmole/mg protein/h) and 30.1-times (0.10 to 3.01 μl/mg protein/min) for Km, Vmax and Vmax/Km, respectively. The mean (±SD) Km, Vmax and Vmax/Km were 72.4±40.4 μM, 4.23±2.88 nmole/mg protein/h and 1.33±1.02 μl/mg protein/min, respectively. Thus, the assay was sufficiently accurate and reproducible to permit estimation of the kinetic parameters of S-mephenytoin 4-hydroxylase in human liver microsomes, and it appears to be applicable to an in vitro study of the possible involvement of S-mephenytoin-type oxidation polymorphism in drug metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02440859
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  • 10
    Electronic Resource
    Electronic Resource
    Measurement of the structure factors of diamond (1990)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 46 (1990), S. 514-517 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The absolute values of the structure factors of diamond are determined for nine low-order reflections by measuring the X-ray Pendellösung beats on the wavelength scale. Parallel-sided wafers of synthetic diamond single crystals are used for specimens. The deformation charge density and the Debye-Waller B factor are evaluated from the structure factors. The charge density of pile-up electrons is estimated to be 0.44(17) eÅ-3 at the midpoint between the nearest-neighbour atoms. The density is slightly smaller than that determined by the powder diffraction method. The obtained B factor, 0.142 (9) Å2, is in good agreement with that evaluated to date from neutron diffraction measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767390002197
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