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  • 1
    Electronic Resource
    Electronic Resource
    Das erregerspezifische Antikörperprofil in den verschiedenen Stadien der HIV-1-Infektion (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 488-493 
    Details
    ISSN: 1432-1440
    Keywords: HIV-1-infection ; Westernblot analysis ; Pattern of antibody response ; Env, core and enzymatic proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The westernblot analysis of 170 patients with HIV-1-infection demonstrated that 47% of the patients in latent stage, 58% of the patients with lymphadenopathy-syndrome and only 25% of the patients with the full-blown picture of AIDS showed the complete pattern of HIV-specific antibody response. This antibody response is mainly directed against the env-encoded envelope proteins gp160, gp120 and gp41, against the gag-encoded core proteins p55, p24 and p17 as well as against the pol-encoded enzymatic proteins p66, p51 and p31. Antibodies against gp160 and gp120 were present in nearly all patients, whereas the prevalence of the other antibodies decreased with the stage of the disease. Statistical significant differences were found particularly between patients with LAS or AIDS respectively. Antibodies against p17 were detected in 74% of the patients with LAS but only in 25% of the patients with AIDS. The lack of antibodies against p17, p24 or p51 was significantly associated with lower mean CD4/CD8-ratios (p〈0,007) and higher mean serum levels of IgA (p〈0,001) and beta-2-microglobulin (p〈0.001). One third of the patients with LAS and this reduced pattern of antibody response developed AIDS within six months. These results demonstrate that the detection of antibodies against p17, p24 or p51 is of prognostic importance. A serological profile which lacks the antibody response against at least two of those three viral antigens indicates a progression of the disease activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01876170
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of aromatic retinoid RO 10-9359 (etretinate) on fingernail growth (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 138-140 
    Details
    ISSN: 1432-069X
    Keywords: Fingernail growth ; Aromatic retinoid ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fingernail growth was studied in 28 patients who were receiving systemic treatment with the aromatic retinoid, Ro 10-9359 known as Tigason (etretinate; AR). A group of 15 patients with psoriasis was compared with a group of 13 patients with other dermatoses which are known to have a good response to AR therapy. In the second group, oral therapy with AR appeared to have no effect on the daily growth rate of fingernails (99±4 μm). With AR treatment, the nail-plate growth rate in the psoriatics increased to 132±5 μm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414112
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  • 3
    Electronic Resource
    Electronic Resource
    Nevoid malignant melanoma (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 362-369 
    Details
    ISSN: 1432-069X
    Keywords: Melanoma ; Nevi, nevocytic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Primary cutaneous malignant melanomas with histological features suggestive of benign nevocytic nevi were studied. From a total of about 3,500 cases, 33 patients with sufficient records, histological slides, and follow-up (at least 5 years for disease-free cases) were found; 15 of them had developed metastases, and 8 had died of disseminated melanoma. Some of the following histological characteristics were always observed: cellular atypia, mitoses, infiltration of adnexa, and in the deeper dermis, infiltrative growth, pigmented tumor cells, sharply demarcated tumor nests, and the absence of maturation. Tumor thickness was the most important prognostic criterion. Clinically, the tumors corresponded to nodular and superficial spreading melanomas. It is concluded that, in rare instances, malignant melanomas strongly resemble benign melanocytic/nevocytic nevi. Such cases do not appear to have a lower degree of malignancy and should be treated as normal malignant melanomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509234
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  • 4
    Electronic Resource
    Electronic Resource
    Collagen synthesis in scleroderma: Selection of fibroblast populations during subcultures (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 373-376 
    Details
    ISSN: 1432-069X
    Keywords: Collagen ; Fibroblast populations ; Scleroderma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In progressive systemic scleroderma, excessive deposition of collagen leads to fibrosis of several tissues including the skin. It has been found that different populations of fibroblasts are present in scleroderma skin; these can be obtained by establishing cell cultures from different layers of the involved skin. Excessive overproduction of collagen was noted in primary cultures of cells obtained from deeper layers of the skin of patients in an early stage of the disease, whereas control fibroblasts did not manifest significant variations dependent on the layers of skin used to initiate the cultures. The synthesis of type-I and-III collagen was found to be altered concomitantly. The production of collagen and collagenous proteins was then followed during subcultivations of overproducing fibroblasts. In many cell strains, increased synthesis of collagen and/or noncollagenous proteins had already been lost after the first subcultivation, whereas overproduction was stable in others. However, after five passages, most of the cultures showed normal collagen synthesis, which probably indicates a loss of phenotype due to successive subcultures or overgrowth by another population of fibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509236
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  • 5
    Electronic Resource
    Electronic Resource
    Reactivity of monoclonal antibody BE 2 in different stages of mycosis fungoides and in benign dermal infiltrates (1986)
    Springer
    Archives of dermatological research 279 (1986), S. 83-88 
    Details
    ISSN: 1432-069X
    Keywords: Mycosis fungoides ; Histopathology ; Benign inflammatory dermatoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cutaneous infiltrate in mycosis fungoides (MF) is predominantly composed of T4-positive T-cells. Attempts to distinguish the early stages of this condition from benign inflammatory infiltrates using anti-T3, T4 and other T-cell-associated antibodies have hitherto been unsucessful. Recently a monoclonal antibody BE 2 has been described as selectively reacting against leukemic cells in patients with cutaneous T-cell lymphoma. To investigate whether the BE 2 antigen is differentially expressed in different stages of MF and benign dermatoses, thus facilitating diagnosis, especially of early MF, the reactivity of monoclonal antibody BE 2 against cutaneous infiltrates from such conditions was assessed. In the early stages of MF only a small number of reactive cells was present. In benign inflammatory infiltrates, especially in those that clinically and histologically were hardly distinguishable from early MF, BE 2 reactivity was essentially the same as in eczematous-stage MF. Lesions from plaque and tumor stage MF contained large numbers of BE 2-reactive cells. Our results indicate that expression of BE 2 is associated with the stage of a given MF lesion and is essentially identical in early MF and eczematous lesions with a similar histopathological appearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417527
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  • 6
    Electronic Resource
    Electronic Resource
    Early persistent UVA-pigmentation: Ultrastructural and morphometric analyses (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 173-179 
    Details
    ISSN: 1432-069X
    Keywords: UV-A pigmentation ; Ultrastructure ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary UV-A-induced skin pigmentation was investigated morphologically in semithin and thin sections from 11 volunteers, using different irradiation modalities (single doses of 10,50 and 100 J/cm2). Visible skin pigmentation was observed in all but two probands, and erythema in two; pronounced pigmentation was present after repeated irradiation only. Contralateral non-irradiated, UV-B-irradiated and suntanned skin specimens were used as controls. There was an increase in the number of clear cells in the basal layer (x 1.6) and particularly of large clear cells (x 1.7) after repeated irradiation. Also, the number of melanosomes in melanocytic dendrites (x 2.8) increased after repeated irradiation. The number, size and shape of the melanosome complexes in both basal and suprabasal keratinocytes remained unchanged, even when a distinction was made between central and peripheral location. In contrast, suntanned skin showed an increase in melanosome complexes in basal (x 5.8) and suprabasal (x 3.7) keratinocytes. It is concluded that UV-A-induced skin pigmentation differs in some ways from UV-B or sun-induced melanogenesis, and that the clinical grade of tanning cannot accurately be determined by ultrastructural methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413253
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  • 7
    Electronic Resource
    Electronic Resource
    Morphometric and ultrastructural analyses of melanocytes, nevus cells, and melanoma cells (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 167-172 
    Details
    ISSN: 1432-069X
    Keywords: Morphometry ; Electron microscopy ; Cytological atypia ; Nevus cells ; Melanoma cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytological atypia, revealed in the course of routine light microscopy, is considered a valuable indicator of malignancy in melanocytic lesions. A clear definition of the term cytological atypia, however, is lacking. Therefore, by morphometric analysis of ultrathin sections of 11 malignant melanomas (7 invasive, 3 in situ, and 1 lentigo maligna melanoma) and 10 compound nevi, we evaluated the discriminating power of the various facets of cytological atypia, i. e., nuclear area, area of the nucleolus, area of the total cell, and nuclear irregularity. In each case, at least 50 intraepidermal melanocytic cells were examined. The two-sided U-test showed significant differences between intraepidermal nevus and melanoma cells, with regard to the mean values (x) and standard deviations (s) of the nuclear area (x and s, p=0.00011), area of the nucleolus (x, p=0.00043; s, p=0.00011), and area of the total cell (x, p=0.00011; s, p=0.00093). However, only the mean values and standard deviations of the nuclear area allowed a clear distinction in each individual case. The area of the nucleus can be estimated in the course of routine histology. We therefore think that the size and variation of the nuclear area should be considered in the histological differential diagnosis between malignant melanomas and benign nevi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413252
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  • 8
    Electronic Resource
    Electronic Resource
    Comparison of different methods for enumeration of Langerhans cells in vertical cryosections of human skin (1988)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 118 (1988), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have quantified Langerhans cells (LC) in cryosections of normal human skin and lesional skin from patients with atopic eczema and psoriasis vulgaris using six different methods. The results from the different methods varied considerably and were sometimes contradictory, for example when LC numbers in psoriatic skin were compared with those in normal skin. Thus, in addition to the staining technique used and the selection of the dendritic cell type to be counted, the enumeration method used can also influence the quantitation of LC in normal and pathological skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1988.tb02432.x
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  • 9
    Electronic Resource
    Electronic Resource
    T4/T8 ratio and absolute T4 cell numbers in different clinical stages of Kaposi's sarcoma in AIDS (1988)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 119 (1988), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirty-seven men (36 homosexual or bisexual and one heterosexual) with epidemic Kaposi's sarcoma and underlying HIV infection were followed up over a period of up to 32 months. Fourteen patients (38%) died, with a median survival time of 7.2 months after the diagnosis of AIDS. Seventeen patients (46%) presented with one or more opportunistic infections, mostly Pneumocystis carinii pneumonia. Eighteen patients (49%) had lymphadenopathy syndrome according to the definition of the CDC. Using the Laubenstein-classification of Kaposi's sarcoma, all patients either remained stable or deteriorated, improvement was never observed. Absolute T4 lymphocyte counts and the T4/T8 ratio were not related to the disease stage. With the onset of B symptoms (systemic symptoms), however, the absolute T4 numbers and the T4/T8 ratio markedly decreased. Delayed type hypersensitivity also showed no relationship to the clinical stages of Kaposi's sarcoma. Thus, the clinical progression of Kaposi's sarcoma lesions seems to be largely independent of the immunological parameters investigated. However, the onset of B symptoms was observed to be related to changes in immune status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1988.tb07095.x
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  • 10
    Electronic Resource
    Electronic Resource
    Keratinocytes in lesional skin of atopic eczema bear HLA-DR, CD1a and IgE molecules (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 14 (1989), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Apparently normal, and lesional skin from patients with atopic eczema were investigated immunohistochemically with anti-HLA-DR, -CD1a and -IgE antisera. A CD1a + intercellular pattern was observed in uninvolved skin in the majority of the patients whereas an HLA-DR +/CD1a+ network, mostly localized in basal and supra-basal areas, was shown in lesional skin of virtually all of them. Moreover, an HLA-DR +/CD1a + IgE + intercellular pattern was observed in some of the patients only and was predominantly localized in those areas characterized by lymphocyte exocytosis, spongiosis or vesicle formation. Whether keratinocytes are able to synthesize CD1a antigen and FcɛR or if these molecules are only produced and shed by CD1a +/IgE + epidermal dendritic cells remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1989.tb00880.x
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