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  • 1
    Electronic Resource
    Electronic Resource
    Knochenmarktransplantation im Erwachsenenalter bei akuter Leukämie, aplastischer Anämie und paroxysmaler nächtlicher Hämoglobinurie (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 321-328 
    Details
    ISSN: 1432-1440
    Keywords: Bone-marrow-transplantation ; Acuteleukemia ; Aplastic-anemia ; Paroxysmal-nocturnal-hemoglobinuria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eleven adults have been transplanted for various reasons between July 1979 and July 1982: 2 with aplastic anemia (AA), 1 with paroxysmal nocturnal hemoglobinuria (PNH), 8 with acute leukemia (AL). Four patients suffered from acute lymphocytic leukemia (ALL) and four from acute non-lymphocytic leukemia (ANLL). Two of them were transplanted in relapse, 1 in a partial remission, and 5 in complete remission. All patients were in their late stage of disease. The PNH-patient had an identical twin, 8 patients had an HLA- and MLC compatible sib, 1 an unrelated donor, and 1 was transplanted from his father. Four patients are alive, 2 more than 3 years: 1 with AA and 1 with ALL who was transplanted in relapse. Six patients died of infectious complications (4 of interstitial pneumonia, 1 of a candidasepsis, 1 of acute toxoplasmosis). Patients living more than 3 weeks had a take. Acute graft-versus-host (GvH) disease did not present a major problem. All patients received methotrexate for GvH-prophylaxis, in three instances the marrow was additionally pre-incubated with anti-T-cell globulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485022
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  • 2
    Electronic Resource
    Electronic Resource
    Ferrokinetics after high-dose methotrexate therapy (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 1109-1113 
    Details
    ISSN: 1432-1440
    Keywords: High-dose methotrexate therapy ; Ferrokinetics ; Erythropoiesis ; Hochdosis-Methotrexat-Therapie ; Ferrokinetik ; Erythropoese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach einer hochdosierten Methotrexat-Therapie mit Dosen von 2–10 g/m2 wurde bei 11 Patienten mit verschiedenen Tumor-Erkrankungen eine Ferrokinetik durchgeführt. Eisen-III-zitrat-59Fe wurde bei Methotrexat-Serum-Konzentrationen zwischen 2,7×10−7 und 1,3×10−8 M injiziert. Bei Methotrexat-Spiegeln ≧4,2×10−8 M war die Plasma-Eisen-Clearance in allen Fällen verlangsamt. Der Plasma-Eisen-Umsatz war bei 5 von 6 Patienten mit MTX-Spiegeln von 3,1–8,9×10−8 M zum Zeitpunkt der Eisen-Injektion vermindert. In allen Fällen mit MTX-Spiegeln über 5×10−8 M war die59Fe-Utilisation als Maß der effektiven Erythropoese pathologisch erniedrigt. Diese Ergebnisse zeigen, daß die Erythropoese erst dann wieder ihr normales Ausmaß annimmt, wenn die MTX-Serum-Konzentrationen unter 5 × 10−8 M abgefallen sind. Damit reagiert die Erythropoese empfindlicher auf Methotrexat als die Granulopoese.
    Notes: Summary After high-dose methotrexate with doses ranging from 2–10 g/m2, ferrokinetics were performed in 11 patients with different tumors. Iron-III-citrate-59Fe was injected at methotrexate serum concentrations ranging between 2.7×10−7−1.3×10−8 M. With MTX levels ≧4.2×10−8 M the plasma iron clearance was always retarded, and the plasma iron turnover was diminished in 5 of 6 patients with levels of 3.1−8.9×10−8 M at the time of the injection. In all cases with MTX concentrations ≧5×10−8 M the59Fe-utilization as the measure of effective erythropoiesis was reduced pathologically below normal range. These results show that the erythropoiesis resumes its normal extent even in case of normal methotrexate clearance only when the methotrexate serum concentrations have fallen down below 5×10−8 and that erythropoiesis is more sensitive against methotrexate toxicity than the granulocytopoiesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01746198
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  • 3
    Electronic Resource
    Electronic Resource
    Vergleichende Studie zum Wert der selektiven Darmdekontamination (SDD) bei der Behandlung akuter Leukämien (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 1093-1099 
    Details
    ISSN: 1432-1440
    Keywords: Selective gut decontamination ; Acute leukemia ; Selektive Darmdekontamination ; Akute Leukämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Hinblick auf eine Senkung der Frühtodesrate durch Infektionen wurde in einer vergleichenden Studie der Wert einer selektiven Darmdekontamination (SDD) bei der zytostatischen Behandlung von Patienten mit akuter Leukämie untersucht. Es wurden drei Gruppen gebildet: 1) SDD (Neomycin, Colistin, Nystatin) bei einfacher Umkehrisolation auf der Normalstation; 2) keine SDD, aber einfache Umkehrisolation auf der Normalstation; 3) strikte Isolation, gefilterte Luft, sterilisierte Nahrung plus SDD. Es fanden sich graduell zwischen den drei Gruppen signifikant weniger Infektionen mit Gramnegativen Keimen: Isolierstation plus SDD versus Normalstation plus SDD versus Normalstation ohne SDD. Die Frühtodesrate durch Infektionen war in der Gruppe mit SDD auf der Normalstation signifikant geringer als in der Gruppe ohne SDD, umgekehrt die Remissionsrate nach zytostatischer Behandlung signifikant höher. Die Dekontamination wurde gut vertragen.
    Notes: Summary A comparative study of infectious morbidity and mortality in neutropenic patients with acute leukemia receiving chemotherapy was undertaken to test the effects of a suppression of endogenous and ambient microorganisms. Patients were allocated to receive [1] oral antibiotics (neomycin, colistin, and nystatin) in conventional ward isolation; [2] no antimicrobial suppression but conventional ward isolation; [3] strict isolation, filtered air, sterilized food and oral antibiotics. Significantly fewer infections with Gram-negative bacilli were seen in patients with strict isolation plus endogenous microbial suppression versus patients receiving selective gut decontamination versus patients without nonabsorbable antibiotics in simple reverse isolation. The death rate from infection was significantly reduced in patients who received antibiotics for gut flora suppression in conventional ward isolation compared with the corresponding control group. In addition, a significant improvement of leukemic remission rate was seen in this group. The protocol for decontamination was well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01746196
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  • 4
    Electronic Resource
    Electronic Resource
    Methotrexate and methotrexate polyglutamates in human sarcoma metastases after high-dose methotrexate therapy (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 1089-1094 
    Details
    ISSN: 1432-1440
    Keywords: High-dose methotrexate ; Methotrexate polyglutamates ; Sarcoma metastases ; Dihydrofolate reductase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The methotrexate concentrations in the lungs or cutaneous metastases of patients with osteogenic or soft-tissue sarcoma were determined at different times after a high-dose methotrexate therapy. The levels in the metastases were 0.964 to 2.96×10−7 molar six to nine days after the end of MTX infusion. They were thus 7.8 to 28 times higher than the corresponding serum levels. At the same time, an appreciable rise of dihydrofolate reductase activity was observed in the metastases. After chromatographic separation over Sephadex G15, MTX polyglutamates could be demonstrated in all tumor samples investigated so far; these amounted up to 68.3% of the total MTX. Taking into account the slower efflux of MTX polyglutamates compared to unchanged MTX, a new hypothesis for the principle of action of high-dose methotrexate therapy is discussed: the very high MTX doses lead to such high intracellular MTX concentrations even in transport-resistant tumor cells that at least part of the MTX is converted into MTX polyglutamates. Unchanged MTX flows relatively rapidly out of the cells, whereas the MTX polyglutamates only break down very slowly and thus can be cytostatically effective over a long period of time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496470
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  • 5
    Electronic Resource
    Electronic Resource
    Immunhämolytische Anämien mit Nierenversagen nach Nomifensineinnahme (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 567-569 
    Details
    ISSN: 1432-1440
    Keywords: Nomifensine ; Immune haemolytic anaemia ; Renal failure ; Nomifensin ; Immuhämolytische Anämie ; Nierenversagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über zwei Fälle von immunhämolytischer Anämie und akutem Nierenversagen nach Nomifensineinnahme. Die beiden Patientinnen hatten wegen reaktiver Depressionen eine kontinuierliche Nomifensintherapie erhalten. In beiden Fällen war das Nomifensin zwischenzeitlich abgesetzt worden, und die klinischen Reaktionen — immunhämolytische Anämie und Nierenversagen — traten unmittelbar nach erneuter Einnahme einer Kapsel dieses Präparates auf. In einem Fall enthielt das Serum der Patientin einen potenten Antikörper, der in Gegenwart von Nomifensin ihre eigenen Erythrozyten im Antiglobulin-Test agglutinierte.
    Notes: Summary Two cases of immune haemolytic anaemia and acute renal failure induced by nomifensine are reported. The two female patients had been under continous nomifensin therapy because of reactive depressions. In both cases nomifensine had been discontinued and the clinical reactions — immune haemolytic anaemia and acute renal failure — started immediately after they had taken again a capsule of nomifensine. In one case the patient's serum contained a potent antibody which agglutinated her red blood cells in presence of nomifensine in the antiglobulin test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716458
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  • 6
    Electronic Resource
    Electronic Resource
    Different types of porphyria cutanea tarda (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 207-208 
    Details
    ISSN: 1432-069X
    Keywords: Porphyria cutanea tarda ; Chronic hepatic porphyria ; Uroporphyrinogen decarboxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414024
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  • 7
    Electronic Resource
    Electronic Resource
    Antifolate effect of triamterene on human leucocytes and on a human lymphoma cell line (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 219-224 
    Details
    ISSN: 1432-1041
    Keywords: triamterene ; folate antagonism ; triamterene metabolites ; dihydrofolate reductase ; DNA metabolism ; human leucocytes ; BJAB-B95-8 ; lymphoma cell line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The inhibitory effect of triamterene and its metabolites on human leucocyte dihydrofolate reductase has been studied. Under test conditions with dihydrofolic acid 0.5×10−5 M, triamterene 7×10−5 M produced total enzyme inhibition, whereas the metabolites hydroxytriamterene and the sulphate ester of hydroxytriamterene were less effective inhibitors; at their maximum attainable concentration of 5×10−5 M, dihydrofolate reductase was inhibited by 80% and 50%, respectively. Cultures of the BJAB-B95-8 human lymphoma cell line were incubated with various concentrations of triamterene. Because of their increased specific activity of dihydrofolate reductase, the cells were able to maintain normal DNA metabolism, as measured by the ratio of the incorporation rates of 3H-deoxyuridine and 3H-thymidine, as well as normal cell growth at 1×10−6 M, and in some cases at 1 × 10−5 M triamterene. At 8×10−5 M triamterene, the strong inhibitory effect caused severe impairment of DNA metabolism and subsequently dissolution of the cell culture. The results are discussed in relation to the possible toxic side effects of long-term triamterene treatment in patients suffering from alcoholic cirrhosis, who may have impaired metabolism of triamterene and a concomitant severe folate deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544601
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  • 8
    Electronic Resource
    Electronic Resource
    Die tumorhemmende Wirkung von Cholestyramin in der Hepatocarcinogenese (1981)
    Springer
    Langenbeck's archives of surgery 354 (1981), S. 19-29 
    Details
    ISSN: 1435-2451
    Keywords: Bile acids ; Diethylnitrosamine ; Hepatocarcinogenesis ; Cholestyramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß von Cholestyramin in der Hepatocarcinogenese wurde an Wistar—Ratten untersucht. Nach 14wöchentlicher intragastraler Applikation von 50 mg Diäthylnitrosamin/kg entwickelten bei simultaner Verabreichung von 1,3 % Cholestyraminzusatz im Futter die Hälfte der Versuchstiere Lebertumoren. Dagegen kam es unter ähnlichen experimentellen Bedingungen, aber ohne Cholestyramin im Futter bei fast allen Tieren der Kontrollgruppe zu Tumorentstehung. Die Sequestration von Gallensäuren und die verminderte Bildung der toxischen Lithocholsäure konnte als Erklärung herangezogen werden, warum im Experiment die Induktion von Lebercarcinom durch Diäthylnitrosamin reduziert wird.
    Notes: Summary The influence of cholestyramine on hepatocarcinogenesis was investigated in the Wistar rat. After 14 weekly gastric instillation of 50 mg diethylnitrosamine/kg and simultaneous administration of diet supplement with 1.3 % cholestyramine, half of the animals developed hepatic tumors. In contrast, nearly all the animals in the control group under similar experimental conditions, but without the cholestyramine supplement in their diet, developed hepatic tumors. The sequestration of bile acids and the reduction of the noxious lithocholic acid could be considered as an explanation for the modification of hepatic tumors induced by diethylnitrosamine in the Wistar rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01834013
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  • 9
    Electronic Resource
    Electronic Resource
    Die Rolle der Sonographie in der Sterilitätsdiagnostik. Eine Anwendung während der Pertubation (1981)
    Springer
    Archives of gynecology and obstetrics 232 (1981), S. 601-602 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429710
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  • 10
    Electronic Resource
    Electronic Resource
    The dexamethasone suppression test and thyroid stimulating hormone response to TRH in RDC schizoaffective patients (1984)
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 264-267 
    Details
    ISSN: 1433-8491
    Keywords: RDC schizoaffective disorder ; Dexamethasone suppression test ; Thyrotrophin releasing hormone test ; DSM-III
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The dexamethasone suppression test (DST) brought to light significantly more non-suppression of cortisol secretion in RDC schizoaffectives of the depressed (89%) and of the manic type (67%) than in RDC schizophrenia (25%). However, only in the RDC endogenous depressives, whose pathological DST rate was 57%, was the thyroid stimulating hormone (TSH) response to thyrotrophin releasing hormone (TRH) found to be significantly “blunted”. It is suggested that the DST results can be interpreted as partially validating DSM-III's wide major affective disorder since this concept also encompasses all cases with mood-incongruent psychotic features. Furthermore, it is hypothesized that the coupling of DST non-suppression and TSH “blunting” may be important for defining a valid depressive subgroup within these extended clinical boundaries for affective illness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381358
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