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  • 1
    Electronic Resource
    Electronic Resource
    Indomethacin induced hypotension in sodium and volume depleted rats (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 143-145 
    Details
    ISSN: 1432-1440
    Keywords: Indometacin ; Plasma-Reninaktivität ; Hypotonie ; Indomethacin ; Plasma Renin Activity ; Arterial Hypotension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary After a single oral dose of 4 mg/kg indomethacin (IDM) to sodium and volume depleted rats plasma renin activity (PRA) and systolic blood pressure fell significantly within four hours. In sodium repleted animals indomethacin did not change systolic blood pressure (BP) although plasma renin activity was decreased. Thus, indomethacin by inhibition of prostaglandin synthesis may diminish the blood pressure maintaining effect of the stimulated renin-angiotensin system in sodium and volume depletion.
    Notes: Zusammenfassung Nach einer einmaligen oralen Gabe von 4 mg/kg Indometacin kam es innerhalb von 4 h bei Natrium- und Volumenverarmten Ratten zu einem signifikanten Abfall der Plasma-Reninaktivität und des systolischen Blutdrucks. Bei normalen Ratten führte die Indometacingabe lediglich zur Erniedrigung der Plasma-Reninaktivität ohne Beeinflussung des arteriellen Blutdruckes. Es wird deshalb angenommen, daß Indometacin über eine Hemmung der Prostaglandinsynthese den Blutdruck stabilisierenden Effekt des Renin-Angiotensin-Systems bei Natrium- und Volumenverarmung, vermindern kann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476055
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Renal hypotension in sodium and fluid deprivation: Experimental findings in renin-depleted rats (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 253-255 
    Details
    ISSN: 1432-1440
    Keywords: Renale Hypotonie ; Reninmangel ; Natriumund Volumenverarmung ; Renal hypotension ; Renin depletion ; Sodium and volume deprivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Arterial hypotension of renal origin occurred as consequence of low plasma renin activity in the presence of sodium and extracellular fluid volume depletion. Secretory insufficiency of the renin-producing juxtaglomerular cells and sodium and volume deprivation, simultaneously, were achieved by removing the “clamped” kidneys in renal hypertensive, sodium- and volume-depleted rats leaving in situ the contralateral kidneys deprived of renin during the preceding period of hypertension. It is suggested that renal hypotension after acute losses of sodium and extracellular fluid may also develop in patients with chronically depressed renin-angiotensin system.
    Notes: Zusammenfassung Eine arterielle Hypotonie renalen Ursprungs wurde als Folge einer niedrigen Plasma-Reninaktivität bei bestehendem Mangel an Natrium und extrazellulärer Flüssigkeit beobachtet. Als experimentelles Modell, an dem eine sekretorische Insuffizienz der Renin-produzierenden juxtaglomerulären Zellen und eine Natrium- und Volumenverarmung gleichzeitig erzeugt werden konnten, dienten vorher hypertone, Natrium- und Volumen-verarmte Ratten nach Entfernung der Drosselnieren und Zurücklassung der während der Hochdruckperiode Renin-verarmten contralateralen Nieren. Es wird angenommen, daß sich eine renale Hypotonie nach akuten Verlusten von Natrium und extrazellulärer Flüssigkeit auch bei Patienten mit chronisch supprimiertem Renin-Angiotensin-System entwickeln kann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477833
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Simultaneous occurrence of perimembranous glomerulonephritis and glomerular amyloidosis (1978)
    Springer
    Virchows Archiv 378 (1978), S. 315-320 
    Details
    ISSN: 1432-2307
    Keywords: Perimembranous glomerulonephritis ; Glomerular amyloidosis ; Therapy with D-penicillamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The results of electron microscopic examination of renal biopsies from 3 patients with rheumatoid arthritis treated with penicillamine are presented. All 3 patients developed a nephrotic syndrome upon discontinuation of penicillamine therapy. When viewed with the electron microscope, segmental forms of perimembranous glomerulonephritis (Stages I–II of Ehrenreich and Churg) and glomerular renal amyloidosis Grade I–III were observed. In all three cases the nephrotic syndrome was considered to be due to the simultaneous occurrence of the two disease processes. In 2 cases perimembranous glomerulonephritis with immuno-complex-deposits was assumed to be the dominant factor in the causation of the disease, in the other case amyloidosis was the principle abnormality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00465597
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Correlations between the morphological and clinical findings in a patient recovering from secondary generalised amyloidosis with renal involvement (1978)
    Springer
    Virchows Archiv 379 (1978), S. 119-129 
    Details
    ISSN: 1432-2307
    Keywords: Secondary amyloidosis ; Healing of nephrotic syndrome ; Electron microscopic investigations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report light- and electron microscopic findings in glomerular amyloidosis (secondary amyloidosis), which occured after recurrent empyema of the pleura. After healing of the empyema, the clinical symptoms disappeared, over a period of eight years. During the acute stage of the disease (grade II–III amyloidosis) when the nephrotic syndrome was present, amyloid deposits were seen in the mesangium and on both sides of the basement membrane of the glomerular capillaries. Furthermore, denuded basement membrane areas showing the passage of amyloid into the urinary space, and invaginations of the podocyte by straightened amyloid fibrils were found. After clinical recovery (except for a trace of proteinuria), the renal amyloidosis had electronmicroscopically transformed from an active into an inactive or resting form, while the amount of amyloid present was almost the same. In the areas of amyloid deposits, reparative changes were observed, especially in the area of the mesangial cells and of the podocytes. The podocytes were separated from the persisting amyloid deposits by newly formed basement membrane material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432481
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    Paper (German National Licenses)
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