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  • 1
    Electronic Resource
    Electronic Resource
    Experimental cerebral ischemia in Mongolian gerbils (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 91-103 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Carbohydrates ; Mongolian gerbils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A cerebral ischemia was produced by unilateral ligation of the common carotid artery in the neck of Mongolian gerbils (Meriones unguiculatus), which are frequently characterized by deficiencies in the circulus of Willis. Concentrations of glucose, lactate, pyruvate and glycogen were measured in the hemisphere on the side of occlusion and in the contralateral control hemisphere of animals sacrificed after 5, 15 and 30 min, as well as after 1, 3, 5 and 9 hrs of carotid clamping. Significant decrease of glucose, and increase in lactate and pyruvate concentration were found in the hemisphere ipsilateral to occlusion; the extent of the changes was proportional to the duration of the ischemia. After an initial fall, an increase in the glycogen content occurred in the later stages of ischemia. Glycogen, glucose, lactate and pyruvate were determined also at 1, 5, 20 hrs and 1 week intervals following release of an occlusion lasting for 1 hr. Return to normal values of glucose and pyruvate was seen at 1 hr after release. The lactate and glycogen levels were significantly raised on the occluded side after 20 hrs release. An increased level of glycogen was observed as long as 1 week after a 1-hr carotid occulusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687536
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental cerebral ischemia in Mongolian gerbils (1976)
    Springer
    Acta neuropathologica 34 (1976), S. 1-6 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Blood-brain barrier ; Mongolian gerbils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The behaviour of the BBB in cerebral ischemia was studied in symptompositive Mongolian gerbils subjected to left common carotid artery occlusion using Evans Blue dye as indicator of BBB injury. The BBB damage was demonstrable grossly by the presence of areas of blue discoloration, and microscopically by the presence of a bright red fluorescent tracer, localized mostly in the neurons. The survey of various groups of animals revealed a direct relationship between the incidence and time of appearance of the BBB lesions and the duration of the ischemic occlusion. This relationship can be interpreted as another example of the previously described “maturation” phenomenon. A relatively late occurrence of the BBB injury in cerebral ischemia, at the time when the affected brain tissue shows severe, edematous histopathologic changes indicates that the brain edema, as the main complication of ischemia, could be regarded as being primarily of the cytotoxic type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684938
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  • 3
    Electronic Resource
    Electronic Resource
    Experimental cerebral ischemia in mongolian gerbils (1976)
    Springer
    Acta neuropathologica 36 (1976), S. 285-294 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Mongolian gerbils ; Ultrastructural changes ; Hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mongolian gerbils exposed to relatively short (7 or 15 min) unilateral or bilateral occlusions of the common carotid artery develop, 20 h after release of the clipping, characteristic morphologic changes in the H3 sector of the hippocampus. Ultrastructural study of these changes revealed an eccentric shift of the nuclei associated with chromatolytic perikarya which showed a dense accumulation of lysosomes and mitochondria in their central parts. The Golgi apparatus was recognizable only by clusters of vesicles, and this change was associated with a negative thiamine pyrophosphatase reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685372
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of 5-minute ischemia in mongolian gerbils: I. Blood-brain barrier, cerebral blood flow, and local cerebral glucose utilization changes (1983)
    Springer
    Acta neuropathologica 60 (1983), S. 207-216 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Blood-brain barrier ; Cerebral blood flow ; Glucose utilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes in morphology, behavior of the blood-brain barrier (BBB), regional cerebral blood flow (rCBF), and local cerebral glucose utilization (LCGU) were assessed and correlated in Mongolian gerbils following 5 min cerebral ischemia, produced by bilateral clamping of the common carotid arteries. The morphological changes were confined to the hippocampus and revealed a conspicuously delayed destruction of the CA1 neurons, occurring after 3 days. Following release of carotid occlusions, there were two separate openings of the BBB. One, occurring shortly after recirculation, was associated with focal hyperemia in the cerebral cortex, hippocampus and basal ganglia; the second opening was observed after several days and was associated with severe neuronal destruction in the CA1 sector. Correlation of quantitative and qualitative rCBF assays with14C-deoxyglucose autoradiographic observations indicated an uncoupling between blood flow and glucose metabolism, observed in the hippocampus at 10 min after recirculation. The described changes provide a further insight into the post-ischemic events which determine the outcome of ischemic injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691868
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  • 5
    Electronic Resource
    Electronic Resource
    Microvascular disturbances and edema formation after repetitive ischemia of gerbil brain (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 288-294 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Brain edema ; Cerebral microcirculation ; Hypoperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three transient episodes of 5 min ischemia spaced at 1-h intervals were produced in Mongolian gerbils by bilateral carotid artery occlusion with an implanted vascular occlusion device. The interval of 1 h was chosen to allow for the development of postischemic hypoperfusion between the ischemic episodes. Three minutes and 1 h after each ischemic episode, and 6 and 24 h after the third occlusion, Evan's blue (EB) was injected intravenously to trace circulating blood, and the number of perfused capillaries was determined in various brain regions by fluorescence microscopy. Brain edema was evaluated by measuring specific gravity in tissue samples taken from adjacent areas. Repetitive ischemia caused progressively increasing brain edema and a progressive reduction of the number of perfused capillaries. Immediately after each ischemic episode, transient recruitment of capillaries occurred, thus excluding noreflow as a main pathogenetic factor of microcirculatory disturbances. The pattern of microcirculation 6 and 24 h after the last occlusion revealed a redistribution of circulating blood, characterized by a reduction in the number of EB-filled capillaries associated with a noticeable dilatation of the larger vascular channels. Our studies suggest a close interrelationship between post-ischemic microcirculatory hypoperfusion and the development of brain edema, the degree and extent of which progresses with the repetition of ischemic episodes when they are carried out during the periods of hypoperfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690537
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  • 6
    Electronic Resource
    Electronic Resource
    The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion (1985)
    Springer
    Acta neuropathologica 68 (1985), S. 122-129 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Blood-brain-barrier ; Cerebral blood flow ; Reactive hyperemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The behavior of the blood-brain barrier (BBB) was studied in cats following release after 1-h middle cerebral artery (MCA) occlusion. The regional cerebral blood flow (rCBF) was determined by hydrogen clearance method in the caudate nucleus and the cerebral cortex. The BBB was assayed with Evans blue (EB) tracer and by immunohistochemical peroxidaseantiperoxidase (PAP) method. Following release of MCA occlusion, there were two openings of the BBB, separated by a refractory period. The first opening, occurred shortly after recirculation; this was associated with rCBF below 15 ml/100 g/min during the ischemic period and a pronounced reactive hyperemia promptly following release of MCA occlusion. A refractory period of the BBB was indicated by the absence of EB leakage in cats injected with the tracer 30 min before killing at 3 h after recirculation, although the rCBF values in these animals were even lower (6±1 ml/100 g/min) during occlusion, and all of them showed a pronounced hyperemia after recirculation. The occurrence of the previous BBB opening in these animals was confirmed by the PAP staining. The second opening of the BBB was observed at 5 and 72 h after recirculation in cats which were injected with EB 30 min before killing, and which showed rCBF below 15 ml/100 g/min during occlusion, followed by a pronounced reactive hyperemia. No EB extravasations were observed at any time in cats in which the rCBF during occlusion was above 15 ml/100 g/min and which failed to show a marked reactive hyperemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688633
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  • 7
    Electronic Resource
    Electronic Resource
    Experimental cerebral ischemia in Mongolian gerbils (1976)
    Springer
    Acta neuropathologica 36 (1976), S. 1-8 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Biogenic amines ; Mongolian gerbils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Behaviour of biogenic amines was studied in the brains of Mongolian gerbils subjected to unilateral occlusion of the common carotid artery. Assays on the hemispheres ipsilateral to occlusion revealed in symptom-positive animals a progressive decrease in norepinephrine and dopamine, and an increase in serotonin throughout the duration of an ischemic insult. In post-ischemic periods following the release of the clip, changes in biogenic amine levels generally conformed to the principles of a previously described “maturation” phenomenon, with delayed reactions occurring after the shorter ischemic insults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685142
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  • 8
    Electronic Resource
    Electronic Resource
    Histochemical investigation of the mongolian Gerbil's brain during unilateral ischemia (1979)
    Springer
    Acta neuropathologica 46 (1979), S. 123-131 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral ischemia ; Mitochondria ; Lysosomes ; Golgi apparatus ; Histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ischemic effect on cerebral enzymes and glycogen content was histochemically evaluated in mongolian, gerbils subjected to unilateral common carotid artery occlusion for various periods of time from 1/2 to 9h. In early stages (up to 2h), the only enzyme affected was the phosphorylase which revealed a decreased activity. Thereafter, the observed changes inclusive of glycogen and other enzymes such as the dehydrogenase, nonspecific acid and alkaline phosphatases, leucine aminopeptidase and thiamine pyrophosphatase progressed proportionally to the duration of ischemia. There was an overall inverse appearance of histochemically demonstrated enzymatic disturbances between the severely damaged ischemic regions and its marginal zones; the former revealing a conspicuous decrease and/or loss of enzymatic activities while the latter showing an increase of the same enzymes. Correlating the various ischemic responses of the intracellular organelles it appears that the changes in the lysosomes and Golgi apparatus occurred slower than those of mitochondria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684813
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