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  • hydrocephalus  (2)
  • hypertension  (2)
  • subarachnoid haemorrhage (SAH)  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Plasma adenosine concentrations are elevated in Dahl salt-sensitive rats (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 227-229 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Adenosine ; Dahl salt-sensitive rats ; high-performance liquid chromatography ; hypertension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract We measured plasma levels of adenosine in Dahl salt-sensitive rats (DS) and Dahl salt-resistant rats (DR) to examine the potential role of adenosine in cardiovascular regulation in this type of hypertension. Plasma adenosine concentrations were significantly higher in DS than in DR. The NaCl content in the diet did not affect plasma adenosine concentration in either DS or DR. Significant positive correlation was found between adenosine concentrations and systolic blood pressure when the data for DS and DR were analyzed together. These results suggest that adenosine may play an important role in the pathophysiology of hypertension in DS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01931102
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  • 2
    Digitale Medien
    Digitale Medien
    Scanning electron microscopy of the subarachnoid macrophages after subarachnoid haemorrhage, and their possible role in the formation of subarachnoid fibrosis (1979)
    Springer
    Acta neurochirurgica 50 (1979), S. 273-280 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Macrophage ; subarachnoid haemorrhage (SAH) ; subarachnoid fibrosis ; scanning electron microscope (SEM)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Sixty dogs with experimental subarachnoid haemorrhage (SAH), repeated SAH, and subarachnoid fibrosis (examined three weeks and three months after SAH, and treated with urokinase or dexamethasone) were examined by scanning electron microscope (SEM). The authors observed the resting and activated macrophages, the erythrophagocytosis, and giant cells in the subarachnoid space after SAH. They consider that the macrophages play an important role in the formation of subarachnoid fibrosis, similar to the role of macrophages in fibrosis in other sites.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01808524
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  • 3
    Digitale Medien
    Digitale Medien
    Effect of antifibrinolytic therapy on subarachnoid fibrosis in dogs after experimental subarachnoid haemorrhage (1980)
    Springer
    Acta neurochirurgica 54 (1980), S. 17-24 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Subarachnoid fibrosis ; subarachnoid haemorrhage (SAH) ; tranexamic acid ; antifibrinolytic therapy ; scanning electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of antifibrinolytic therapy on posthaemorrhagic subarachnoid fibrosis was observed experimentally in dogs with the scanning electron microscope (SEM). The subchronic subjects, given intravenous injections of tranexamic acid (1 mg/day) for 12 days and sacrificed 3 weeks after cisternal blood injection, showed residual clot with thick fibrosis, especially around the haemorrhage. The chronic subjects, to which the same procedure was applied and which were sacrificed three months after cisternal blood injection, showed significant increases in the subarachnoid fibrosis, most remarkably in the parasagittal region. Tranexamic acid is widely used for preventing the recurrence of subarachnoid haemorrhage. However, it was revealed in this study that antifibrinolytic therapy might increase chronic posthaemorrhagic subarachnoid fibrosis, which is considered to be responsible for communicating hydrocephalus by disturbing epicortical CSF flow4.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01401939
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  • 4
    Digitale Medien
    Digitale Medien
    Changes in the subarachnoid space after experimental subarachnoid haemorrhage in the dog: Scanning electron microscopic observation (1977)
    Springer
    Acta neurochirurgica 39 (1977), S. 1-14 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Subarachnoid hemorrhage ; hydrocephalus ; subarachnoid fibrosis ; scanning electron microscope
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The possible changes in the subarachnoid space after subarachnoid haemorrhage were studied in animals by using a scanning electron microscope (SEM). About 1 ml/kg of autogenous blood was injected intracisternally in 36 adult mongrel dogs to investigate changes in the subarachnoid space, over periods ranging from immediately after the injection to as long as 6 months. We have come to the conclusion that the injected blood disappears in about one to two weeks; the fibrosis or thickening of the arachnoid membrane appears in one to three weeks, and then returns to normal in a month in instances of rapid recovery, but there are some cases in which fibrosis persists for a long period and becomes chronic. The fact that an increase of fibrous tissue was found in the parietal region, where the injected blood had hardly reached, appears to indicate that the fibrosis is not always limited to the site of the haemorrhage but can occur in remote regions. We also discuss the usefulness of the SEM in the observation of the subarachnoid space, and the finding that vascular specimen preparations can be made by perfusing the brain with 2–10% phosphate-buffered formaldehyde solution.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01405236
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  • 5
    Digitale Medien
    Digitale Medien
    Subarachnoid haemorrhage and communicating hydrocephalus scanning electron microscopic observations (1979)
    Springer
    Acta neurochirurgica 50 (1979), S. 265-272 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Electron microscope ; subarachnoid haemorrhage ; hydrocephalus ; subarachnoid fibrosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Scanning electron microscopic changes in the subarachnoid space after subarachnoid haemorrhage are described. The obstructive changes were classified into five grades ranging from patency to total obstruction. We report a correlation between communicating hydrocephalus and obstruction above grade 3 in the parasagittal region (p 〈 0.01) and the lateral cerebral fissure (p 〈 0.05).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01808523
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  • 6
    Digitale Medien
    Digitale Medien
    Renal and hormonal effects of alpha1-adrenoceptor blockade by bunazosin in essential hypertension (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 575-578 
    Details
    ISSN: 1432-1041
    Schlagwort(e): bunazosin ; hypertension ; alpha1-adrenoceptor blocker ; blood pressure ; renal blood flow ; renal function ; renin ; aldosterone ; atrial natriuretic peptide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The renal and hormonal effects of the α1-adrenoceptor blocker bunazosin were examined in 6 patients with essential hypertension. Oral bunazosin for 4 to 12 weeks significantly decreased mean blood pressure by 10%, increased effective renal blood flow and creatinine clearance by 34% and 37%, respectively, the plasma norepinephrine concentration was elevated by 60%, and the plasma atrial natriuretic peptide level was lowered by 22%. The plasma renin activity and aldosterone concentration were unchanged. Thus, a moderate reduction in blood pressure was produced by bunazosin treatment while maintaining renal perfusion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00637738
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