Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Electronic Resource
    Electronic Resource
    Morphological Purkinje cell changes in spinocerebellar ataxia type 6 (2000)
    Springer
    Acta neuropathologica 100 (2000), S. 371-376 
    Details
    ISSN: 1432-0533
    Keywords: Key words SCA6 ; Purkinje cell ; Immunohistochemisry ; Calbindin-D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spinocerebellar ataxia type 6 (SCA6) was recently identified as a form of autosomal dominant spinocerebellar ataxia associated with a small CAG repeat expansion of the gene encoding an α 1 A-voltage-dependent calcium channel gene subunit on chromosome 19p13. In this study 50-μm-thick sections of cerebellar tissue from one patient with SCA6 were subjected to free-floating immunohistochemical staining with calbindin-D and parvalbumin antibodies. Severe loss of Purkinje cells was found, particularly in the vermis, and various morphological changes in Purkinje cells and their dendritic arborizations were demonstrated. Many of the remaining Purkinje cells were found to have heterotopic, irregularly shaped nuclei, an unclear cytoplasmic membrane outline, and somatic sprouts. Increased numbers of spine-like protrusions from swelling dendritic arborizations were found in the molecular layer. The axonal arrangement was disordered, and many torpedos were found in the granular layer and white matters. These morphological changes are completely different from those observed in paraneoplastic cerebellar degeneration (PCD) and multiple system atrophy (MSA) and are considered to be related to the genetic abnormality that causes abnormal development of Purkinje cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010000201
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    Effects of endotoxin elimination therapy using PMX in patients with septic shock (1996)
    Springer
    Intensive care medicine 22 (1996), S. S36 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions DHP with PMX appears to be more effective in patients with intraabdominal infection that is mainly derived from GNR and could be drained surgically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01921210
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    Value of color doppler ultrasonography for assessing fulminant hepatitis (1996)
    Springer
    Intensive care medicine 22 (1996), S. S50 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion Color Doppler US is a valuable diagnostic tool in evaluating or predicting prognosis of fulminant hepatic failure as it is simple and provides more accurate information about portal circulation than the other existing modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01921224
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    Estrogen reduces the excitability of the female rat medial amygdala afferents from the medial preoptic area but not those from the lateral septum (1994)
    Springer
    Experimental brain research 101 (1994), S. 1-7 
    Details
    ISSN: 1432-1106
    Keywords: Amygdala ; Estrogen ; Preoptic area ; Septum ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Electrical stimulation of the medial amygdala (AMY) elicited antidromic action potentials in neurons in the preoptic area (POA) and the lateral septum (LS) of 36 urethane-anesthetized ovariectomized female rats, which were either treated with estrogen o not treated. The extracellular potentials from the two sites showed similar characteristics, with the exception of the sensitivity to estrogen: they had latencies between 3 and 35 ms. Thresholds were as low as 100 μA. The mean relative refractory period was 2.2 ms. The peak-to-peak amplitudes of the positive-negative biphasic potential ranged from 1.0 mV to 12.0 mV. Estrogen had site-specific effects on parameters of antidromic activation in the POA. Estrogen-treated rats had a significantly higher threshold (937 vs 664 μA) and a longer refractory period (2.5 vs 2.1 ms) than the ovariectomized rats (P 〈 0.05 for each). The effects were absent in the LS. Selective cutting of the stria terminalis diminished the AMY-induced antidromic responses in the POA and LS. Electrical stimulation of the stria blocked the AMY-induced antidromic potentials by collision. Thus, estrogen-sensitive POA efferents as well as non-estrogen-sensitive LS efferents project to the AMY via the stria terminalis. Reductions in axonal excitability would inhibit neural conduction and transmission. Estrogen may therefore reduce the AMY inputs from the POA, without affecting those from the LS. Such alterations in the neural impulse flow may underlie estrogen-dependent neuroendocrine or behavioral regulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00243211
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 15
    Electronic Resource
    Electronic Resource
    Formation of functional synapses in the adult cat red nucleus from the cerebrum following cross-innervation of forelimb flexor and extensor nerves (1982)
    Springer
    Experimental brain research 45 (1982), S. 13-18 
    Details
    ISSN: 1432-1106
    Keywords: Sprouting ; Red nucleus ; Cross innervation ; Unitary corticorubral EPSPs ; Cable properties
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of cross-innervation of peripheral flexor and extensor nerves on the time course and properties of red nucleus (RN) neurons were studied in adult cats. The time course of corticorubral unitary EPSPs was examined. In operated cats, RN neurons innervating upper spinal segments (C-cells) manifested corticorubral unitary EPSPs with shorter time-to-peak and larger amplitude than in normal cats. The mean amplitude of these EPSPs was 0.41 ± 0.11 mV; the mean time-to-peak was 1.14 ± 0.51 ms (n = 18). These values differ from normal cats (0.33 ± 0.09 mV, and 2.68 ± 0.61 ms, n = 22). RN neuron membrane properties were examined in cross-innervated cats. The main time constant was 5.2 ± 0.7 ms (n = 10), the shorter equalizing time constant, 0.69 ± 0.19 ms (n = 10), the input resistance, 2.5 ± 0.8 MΩ. These values were not significantly different from those of normal cats. The electrotonic length was 1.2 (n = 10), somewhat larger than in normal cats. The number of converging interposito-rubral synapses, estimated in eight cells from cross-innervated cats, ranged from 37 to 57. This was not significantly different from normal cats, and indicated that there is no large-scale degeneration of interpositorubral synapses after cross-innervation. These results suggest that sprouting and formation of functional synapses occur after cross-innervation of peripheral flexor and extensor nerves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235758
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 16
    Electronic Resource
    Electronic Resource
    Supraspinal monosynaptic excitation and inhibition of thoracic back motoneurons (1970)
    Springer
    Experimental brain research 11 (1970), S. 282-295 
    Details
    ISSN: 1432-1106
    Keywords: Thoracic motoneurons ; Supraspinal ; Monosynaptic IPSP, EPSP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of brain stem stimulation on thoracic back motoneurons were studied in cats anesthetized with pentobarbital. The population sampled consisted of the extensors interspinales (IS), longissimus dorsi (LD) and spinalis dorsi (SD), and of unidentified (UIC) motoneurons. The location of the motoneurons, between Th 1 and Th 10, at widely varying distances from the stimulating electrode permitted linear regression analysis of the descending neural influences. EPSPs evoked by MLF stimulation in all types of motoneurons were produced by a pathway with an average conduction velocity in the thoracic cord of 127 m/sec, and were monosynaptic. IPSPs were also produced by MLF stimulation. The IPSPs in IS and UIC motoneurons were monosynaptic and were produced by a pathway with an average conduction velocity of 69 m/sec. Stimulation of Deiters' nucleus evoked short latency EPSPs in many motoneurons. EPSPs in LD and UIC motoneurons were shown to be monosynaptic, although latency scatter and sample size made accurate determination of vestibulospinal conduction velocity impossible. Stimulation of the labyrinth evoked disynaptic EPSPs and IPSPs in many cells, as previously observed in neck motoneurons. IPSPs were frequently produced by stimulation of the contralateral labyrinth, probably by a pathway with a relay in the contralateral medial vestibular nucleus. Ipsilateral stimulation usually produced EPSPs. The excitatory pathway relays in Deiters' nucleus and, we suggest, in the descending vestibular nucleus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01474387
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 17
    Electronic Resource
    Electronic Resource
    The origin of cerebellar-induced inhibition of Deiters neurones I. Monosynaptic initiation of the inhibitory postsynaptic potentials (1966)
    Springer
    Experimental brain research 2 (1966), S. 330-349 
    Details
    ISSN: 1432-1106
    Keywords: Deiters neurones ; IPSP ; Monosynaptic ; Purkinje cells ; Inhibitory neurones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During stimulation of the anterior lobe of the cerebellum, postsynaptic potentials were recorded intracellularly from ipsilateral Deiters neurones of the cat. In the majority of examined cells, the inhibitory postsynapic potentials were induced with short latency; 1.06 msec on the average from lobule III or IV. The latency was longer (1.23 msec) when the lobule V was stimulated, while it was shorter (0.86 msec) from the juxtafastigial region. It follows that the IPSP was produced via a monosynaptic pathway at a conduction velocity of 15 to 20 m/sec. Recording of the extracellular field potentials and focal stimulation within and around Deiters' nucleus further indicated that the inhibitory impulses propagated out of the cerebellum along a remarkable bundle of fibres which terminated within Deiters' nucleus. These results are all explicable by assuming that the cerebellar Purkinje cells are inhibitory in nature and so produce IPSPs monosynaptically in Deiters neurones via the long corticofugal fibres. Monosynaptic EPSPs were also detected in some Deiters neurones. They are considered to be mediated by the other pathways formed of axon collaterals of the cerebellar afferents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234779
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 18
    Electronic Resource
    Electronic Resource
    Inhibitory control of intracerebellar nuclei by the Purkinje cell axons (1970)
    Springer
    Experimental brain research 10 (1970), S. 64-80 
    Details
    ISSN: 1432-1106
    Keywords: Intracerebellar nuclei ; Purkinje cells ; Inhibition ; Excitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In anaesthetized cats, synaptic events in cerebellar nuclei neurones were investigated with intracellular microelectrode techniques. These cells were identified by their antidromic activation along their axons and/or by their location in histological sections. In the cells of lateral nucleus IPSPs were induced monosynaptically during stimulation of the overlying hemispheral cortex of the cerebellum. In the cells of nuclei interpositus and fastigii, similar IPSPs were produced from the paravermal and vermal cortices, respectively. The postulate that the Purkinje cells exert an inhibitory action upon their target neurones thus applies not only to Deiters neurones, as previously proposed, but also to cells in the cerebellar nuclei. Stimulation of the cerebellar afferents at the inferior olive, the pontine nucleus and the lateral reticular nucleus produced EPSPs in cerebellar nuclei cells with relatively brief latencies, probably through axon collaterals of these afferents. The EPSPs were followed by IPSPs and slow depolarizations of disinhibitory nature, which, as studied previously in Deiters neurones, might be caused respectively by activation and subsequent depression of Purkinje cells through the cerebellar intracortical mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340519
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 19
    Electronic Resource
    Electronic Resource
    The mode of cerebello-thalamic relay transmission investigated with intracellular recording from cells of the ventrolateral nucleus of cat's thalamus (1970)
    Springer
    Experimental brain research 10 (1970), S. 121-139 
    Details
    ISSN: 1432-1106
    Keywords: VL neurones ; Cerebellum ; Cerebrum ; EPSP ; IPSP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Cerebello-thalamo-cortical relay transmission was studied by intracellular recording from cells of the ventrolateral (VL) nucleus of cat's thalamus. The VL relay cells were identified by their antidromic invasion from the pericruciate cortex as well as by their monosynaptic activation from the cerebellar nuclei. 2. Impulses conducting along the cerebello-thalamic pathway at a mean velocity of 18 m/sec produced in VL relay cells excitatory postsynaptic potentials (EPSPs) monosynaptically. Cerebello-thalamic transmission was characterized by relatively large sizes of unitary EPSPs that amounted to 0.8–3.2 mV in peak amplitude. Spontaneously arising EPSP-noise had a similarly large unitary size. 3. The spot from which the EPSPs were produced with the lowest threshold was determined for each of 50 VL relay neurones. The EPSP origin thus determined lay within both lateral and interpositus nuclei. 4. The cerebellar-evoked EPSPs were often followed by inhibitory postsynaptic potentials (IPSPs) with an additional delay of 0.9–2.5 msec. The possibility is suggested that this inhibitory pathway contains at least one interneurone, presumably located within VL. For 10 VL relay cells, the low threshold points for inducing the polysynaptic IPSP were found to be distributed within the interpositus nucleus. 5. Stimulation to the pericruciate cortex produced EPSPs monosynaptically in VL relay cells, the pathway having a conduction velocity of 4–14 m/sec. The time course of the cortical-evoked EPSPs was characteristically slow, in contrast to that of the cerebellar induced EPSPs. This suggests that cortico-thalamic fibers make contact with the peripheral dendrites of the VL neurones, whereas the cerebello-thalamic ones impinge onto their somas or proximal dendrites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234726
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 20
    Electronic Resource
    Electronic Resource
    The mode of pallido-thalamic transmission investigated with intracellular recording from cat thalamus (1978)
    Springer
    Experimental brain research 33 (1978), S. 493-507 
    Details
    ISSN: 1432-1106
    Keywords: VL-VA neurons ; Entopenduncular nucleus (Pallidum) ; Monosynaptic inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pallido-thalamic transmission was studied by intracellular recording from neurons in the ventrolateral (VL) and ventroanterior (VA) nuclei of the thalamus in cats anesthetized with pentobarbital. Stimulation of the entopeduncular nucleus (ENT) produced short latency, inhibitory postsynaptic potentials in the VL-VA neurons (1.60 ms on average). When stimuli were applied closer to the VL-VA region along the pallido-thalamic pathway, i.e., to the rostral Forel's field, the IPSP latency was significantly reduced. Linear regression analysis of the IPSP latency against conduction distance between different stimulating and recording positions indicated that the IPSP was produced through a monosynaptic pathway at a conduction velocity of 5 to 11 m/s. The neurons which received IPSPs from the ENT distributed in the rostromedial VL and in the rostral VA, whereas relay cells responding only to the contralateral brachium conjunctivum were found in the caudal VL and in the dorsolateral portion of the rostral VL-VA complex. Reciprocal convergence of pallidal and cerebellar impulses were observed in only a small number of cells, which were located in the border between the two neuron groups. Recording of extracellular field potentials and focal stimulation within and around the rostral VL also indicated that the fiber potentials arose from the ENT nucleus and propagated along a bundle of fibers which terminated within the rostromedial VL-VA complex. These results are all explicable by assuming that the entopeduncular neurons are inhibitory in nature and so inhibit thalamic neurons monosynaptically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235570
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...