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  • 1
    Electronic Resource
    Electronic Resource
    Infektprophylaxe bei der Induktionstherapie akuter Leukämien (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 1075-1079 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01746194
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  • 2
    Electronic Resource
    Electronic Resource
    Antimicrobial prophylaxis in acute leukaemia: Prospective randomized study comparing two methods of selective decontamination (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 691-698 
    Details
    ISSN: 1432-1440
    Keywords: Acute leukaemia ; Infection prophylaxis ; Selective decontamination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a prospective study the efficacy of two regimens for selective decontamination of the digestive tract was studied in patients with acute leukaemia during remission induction therapy. Seventy-eight patients were randomized to receive either a combination of cotrimoxazole, polymyxin B and nystatin (group A) or a combination of nalidixic acid, polymyxin B, neomycin and nystatin. With both regimens the gastrointestinal tract could be decontaminated equally effectively from potential pathogens. In the oropharyngeal region the decontamination from Enterobacteriaceae was significantly better in group A (P〈0.01). In both groups less than 10% of the acquired infections were caused by gram-negative bacilli and no gram-negative septicaemia occurred in either group. The median time interval until the first acquired infection was 17 days in group A and 36 days in group B, respectively (P〈0.05). It is concluded that regimen A might be more effective than regimen B though both regimens prevent reliably severe gram-negative infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487614
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  • 3
    Electronic Resource
    Electronic Resource
    High risk of streptococcal septicemia after high dose cytosine arabinoside treatment for acute myelogenous leukemia (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 773-780 
    Details
    ISSN: 1432-1440
    Keywords: Streptococci ; Septicemia ; Acute leukemia ; High dose cytosine arabinoside
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-nine adult patients with acute myelogenous leukemia AML who received 40 treatment courses with high dose cytosine arabinoside (HD-A), alone or combined with other cytotoxic drugs, for remission induction (RI) or postremission intensive consolidation (IC) were retrospectively analysed for types and severity of infectious complications. In this paper, we report the unusually high rate of streptococcal septicemia in our patients. Of 13 bacteremic infections in a total of 45 infectious episodes, 10 were caused by streptococci (9 viridans streptococci, 1 group B hemolytic streptococcus). Three of them were lethal. After reviewing all documented cases of streptococcal septicemia in the same study period, four additional cases among adult patients with AML were identified. Three of them have had antileukemic chemotherapy without HD-A, while one have had HD-A as a conditioning regimen for bone marrow transplantation. Only three cases were documented to occur in adult patients with AML. Patients treated with HD-A for RI or IC had a significantly lower risk of streptococcal septicemia during previous chemotherapy-associated febrile neutropenic episodes (1/55 vs 10/45;P=0.01). Neither prophylactic regimens including trimethoprim-sulfamethoxazole nor those without it were effective in preventing streptococcal septicemia. Further studies are needed to confirm these data before the value of additional or alternative prophylactic antibiotics is proven necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01743253
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Bedeutung unterschiedlicher Eliminationskonstanten von LDH-Isoenzymfraktionen für die Zusammensetzung der SLDH-Verteilungsmuster beim Menschen (1969)
    Springer
    Journal of molecular medicine 47 (1969), S. 903-909 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The behaviour of the Serum Lactate Dehydrogenase activity has been examined in 9 patients with myocardial infarction and in 6 patients with acute liver damage. The increased enzyme activity of the first group of patients decreased to the standard value of LDH 8 times slower than that of the second group. The cause of this might be the different composition of the LDH isoenzyme patterns of both diseases with the corresponding different inactivation of the enzyme activity. In 10 cases of acute myeloid leucemia the LDH isoenzyme patterns of the serum have been compared with those of the LDH in the leucemic myeloblasts of each of the respective patients. In all cases distinct differences between the encyme patterns could be proved. Compared with the composition of the LDH in the myeloblasts the composition of the serum LDH showed a decreasing surplus from the LDH I down to the LDH V. It could be excluded with reasonable certainity that other essential sources than the myeloblasts for the serum-LDH exsisted. A selective effusion of LDH isoencyme fractions out of the leucemic myeloblasts into the environs could not be proved by incubation tests. If we assume that the cause of disproportion between the enzyme patterns of the myeloblasts and the respective sera is a different quick elimination of the LDH isoenzyme fractions, then the elimination rates from LDH I to LDH V should show the following ratios: 1:1,6:4,4:11:26. They resemble those of the animal test regarding their exponential increase from LDH I to LDH V and at least similar in their range.
    Notes: Zusammenfassung Das Verhalten der Serum-Lactatdehydrogenase-Aktivität wurde bei 9 Patienten mit Myokardinfarkt und 6 Patienten mit akutem Leberparenchymschaden untersucht. Die erhöhte Enzymaktivität fiel in der ersten Patientengruppe 8mal langsamer zum Normwert ab als in der zweiten Gruppe. Als Ursache ist die sehr unterschiedliche LDH-Isoenzymzusammensetzung bei beiden Krankheitsbildern mit entsprechend unterschiedlich rasch ablaufendem Inaktivierungsprozeß für die Enzymfraktionen anzunehmen. Bei 10 Fällen akuter Paraleukoblastose wurde das LDH-Isoenzymmuster im Serum mit dem der Paraleukoblasten des jeweiligen Patienten verglichen. In jedem Fall waren deutliche Unterschiede zwischen den Enzymmustern nachzuweisen. Gegenüber der Zusammensetzung der LDH in Paraleukoblasten wies die der Serum-LDH bei allen Patienten übereinstimmend einen von der LDH I zu LDH II abnehmenden Überschuß und ein von der LDH III zur LDH V ansteigendes Defizit an Aktivität auf. In allen Fällen war ein wesentlicher LDH-Einstrom aus anderen Organzellen als den Paraleukoblasten weitgehend auszuschließen. Eine selektive Abgabe von LDH-Isoenzymfraktionen aus den Paraleukoblasten in das Umgebungsmilieu ließ sich bei Inkubationsversuchen nicht nachweisen. Setzt man als Ursache der Dysproportion zwischen den Enzymmustern der Paraleukoblasten und des jeweiligen Serums einen unterschiedlich schnellen Inaktivierungsprozeß für die LDH-Isoenzymfraktionen voraus, dann gelangt man zu Eliminationsraten, die von der LDH I zur LDH V in einem Verhältnis von 1/1,6/4,4/11/26 ansteigen. Sie gleichen den im Tierversuch ermittelten durch ihren exponentiellen Anstieg von LDH I zu LDH V und wenigstens annähernd auch in ihrer Größenordnung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01486266
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  • 5
    Electronic Resource
    Electronic Resource
    The efficiency of strict reverse isolation and antimicrobial decontamination in remission induction therapy of acute leukemia (1980)
    Springer
    Annals of hematology 40 (1980), S. 187-195 
    Details
    ISSN: 1432-0584
    Keywords: akute LeukÄmie ; Infektionsprophylaxe ; antimikrobielle ; Dekontamination ; reverse Isolation ; Remissionsraten ; Acute leukemia ; Prevention of infection ; Antimicrobial decontamination ; Reverse isolation ; Remission rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The efficiency of strict reverse isolation and antimicrobial decontamination in remission induction therapy of acute leukemia was studied retrospectively in 47 patients who were treated with a standardized aggressive chemotherapy of daunorubicin and cytosine arabinoside. Twenty-two patients were treated in strict reverse isolation with antimicrobial decontamination and 25 patients in the open ward without any measures against infections. In the patients in isolation the incidence of new infections per patient was 0.77 compared to 1.42 in the control group. The rate of complete remissions was 77% in the patients in isolation vs. 56 % in the control patients.
    Notes: Zusammenfassung Die Wirksamkeit von strikter reverser Isolation und antimikrobieller Dekontamination bei der Induktionstherapie der akuten LeukÄmie wurde retrospektiv bei 47 Patienten untersucht. Alle Patienten erhielten eine standardisierte aggressive Chemotherapie mit Daunorubicin und Cytosin-Arabinosid. Zweiundzwanzig Patienten wurden in strikter reverser Isolation mit antimikrobieller Dekontamination behandelt, 25 Patienten auf normalen Krankenstationen ohne Ma\nahmen zur Infektionsprophylaxe. Die HÄufigkeit neuer Infektionen pro Patient war 0,77 bei den isolierten Patienten und 1,42 in der Kontrollgruppe. Die Rate kompletter Remissionen betrug bei den isolierten Patienten 77% im Vergleich zu 56% bei den Patienten auf den normalen Krankenstationen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01008576
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  • 6
    Electronic Resource
    Electronic Resource
    Thrombotic thrombocytopenic purpura in early pregnancy with maternal and fetal survival (1992)
    Springer
    Annals of hematology 64 (1992), S. 245-248 
    Details
    ISSN: 1432-0584
    Keywords: Thrombotic thrombocytopenic purpura ; Pregnancy ; Plasma exchange ; Plasma infusions ; Antiplatelet agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thrombotic thrombocytopenic purpura (TTP) is a hematologic disorder which is clinically characterized by thrombocytopenia, microangiopathic hemolytic anemia, fever, neurologic symptoms, and cardiac and renal involvement. The pathogenic mechanisms of this disease are poorly understood. It is well known that TTP is associated with pregnancy and that prognosis for the mother and child is poor. We present the first case of a severe TTP diagnosed in the first trimester of pregnancy (13th week of gestation) with maternal survival and birth of a healthy child which required continuous and intensive treatment with plasmatherapy until delivery. During a period of 24 weeks several attempts to discontinue plasma therapy failed because of continuous active disease, and it became evident that plasma infusions were not as effective as plasma exchanges. The fact that the patient entered into remission soon after delivery of a healthy child by cesarean section in the 37th gestational week shows that in this case pregnancy activated an unknown factor which does not cross the placenta and which can be removed by plasmapheresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01738304
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  • 7
    Electronic Resource
    Electronic Resource
    Book reviews (1982)
    Springer
    Annals of hematology 45 (1982), S. 359-361 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319531
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  • 8
    Electronic Resource
    Electronic Resource
    Culture of human haemopoietic cells in diffusion chambers (1979)
    Springer
    Annals of hematology 38 (1979), S. 383-389 
    Details
    ISSN: 1432-0584
    Keywords: Diffusionskammertechnik ; periphere Blutzellen ; Normalwerte ; Diffusion chambers ; Peripheral blood cells ; Normal values
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Growth of mononuclear cells from human peripheral blood from 10 normal individuals was tested in diffusion chamber culture over a period up to 17 or 21 days. After an initial decrease during the first few days an increase of the total cell number was observed with maximal values on day 13. In all individuals growth of undifferentiated blast cells, lymphocytes, plasma cells, immature and mature granulopoietic cells, macrophages, and megakaryocytes occurred. In all individuals the different cell types had similar growth patterns in diffusion chamber culture. The considerable numerical variations which were seen in the granulopoietic cells were probably due to different stem cell concentrations in the peripheral blood of the investigated individuals. The results indicate that the diffusion chamber technique is a valuable method for the detection of haemopoietic stem cells and the culture of lymphocytic cells in man.
    Notes: Zusammenfassung Das Wachstum mononukleärer Zellen des peripheren Blutes in der Diffusionskammerkultur wurde bei 10 Normalpersonen über einen Zeitraum von 17 bis 21 Tagen untersucht. Während der Kultur kam es nach einem initialen Abfall zu einem Anstieg der Gesamtzellzahl mit einem Maximum am 13. Tag. Bei allen untersuchten Individuen zeigte sich eine gute übereinstimmung in den Wachstumsmustern der einzelnen Zellarten. Erhebliche numerische Schwankungen wurden jedoch bei den granulopoetischen Zellen beobachtet, wo sie auf unterschiedliche Stammzellkonzentrationen im Blut der untersuchten Personen zurückgeführt werden müssen. Die Ergebnisse zeigen, da\ die Diffusionskammertechnik eine wertvolle Methode zum Nachweis hämopoetischer Stammzellen und zur Kultur lymphatischer Zellen beim Menschen darstellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01007899
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  • 9
    Electronic Resource
    Electronic Resource
    A multicentre study on intensive induction and consolidation therapy in acute myelogenous leukaemia (1988)
    Springer
    Annals of hematology 56 (1988), S. 233-236 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320111
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  • 10
    Electronic Resource
    Electronic Resource
    Treatment results of nine patients with burkitt's lymphoma (1986)
    Springer
    Annals of hematology 53 (1986), S. 279-286 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkins Lymphoma ; Burkitt's Lymphoma ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From 6/79 until 2/86, 9 patients (median age 39) with Burkitt's lymphoma were treated. Stage D disease was seen in 7 cases, stage C in two and stage A in one. The main symptom was abdominal pain or a rapidly progressing abdominal tumor. Three patients had bone marrow involvement and two had a Burkitt's leukemia. Three had typical chromosomal aberrations. Therapy consisted of a variety of chemotherapy regimens plus additional radiotherapy and/or bulk surgery. Two patients achieved complete remissions (of 6 and 20+ months duration), and 4 partial remissions were obtained. The remaining patients had either progressive, drug resistant disease or died early. One patient is currently alive and in complete remission at 20+ months. A second patient is alive at 20+ months in partial remission with traces of IgM-paraprotein still detectable. The main causes of death were tumor-lysis syndrom (4 patients) and therapy related sepsis with progressive tumor (3 patients). This poor outcome is probably due to a high proportion of high-risk patients and suboptimal therapy for this rapidly proliferating tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320885
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