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  • 1
    Digitale Medien
    Digitale Medien
    EXPERIMENTAL CHEMICAL PRODUCTION OF BRAIN TUMORS (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 381 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb50390.x
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  • 2
    Digitale Medien
    Digitale Medien
    Die Janusköpfigkeit der Chemotherapie: Eine Stellungnahme zu den Thesen von Abel (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 49-51 
    Details
    ISSN: 1432-1440
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01649059
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  • 3
    Digitale Medien
    Digitale Medien
    Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium(IV) compounds (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 109-110 
    Details
    ISSN: 1432-1335
    Schlagwort(e): cis-Dihalogenobis(1-phenyl-1,3-butanedionato)-titanium(IV) ; Antitumor activity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium(IV) compounds against L 1210 leukemia as compared with cis-diamminedichloroplatinum(II) (Cisplatin, cis-DDP, NSC 119875) was investigated. The tested compounds showed an enhanced effect and a lower toxicity compared with Cisplatin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00391842
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  • 4
    Digitale Medien
    Digitale Medien
    Induction of tumors of the forestomach in rats by oral application of N-methyl-N′-nitro-nitrosoguanidine (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 194-196 
    Details
    ISSN: 1432-1335
    Schlagwort(e): N-Methyl-N′-nitro-N-nitrosoguanidine ; tumors in forestomach ; glandular stomach ; liver
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary After 12 oral applications of 80 mg/kg MNNG as a suspension in 30% aqueous ethanol at weekly intervals, 98 Sprague-Dawley rats died with multiple tumors of the forestomach after a medium latency period of 226 days. Histological examination showed generalized papillomatosis developing into keratinizing squamous cell carcinomas with infiltrative growth in 88/98 (89%) animals. Tumorigenic lesions in the glandular stomach ware only observed in 3/98 rats. In two of these animals, mucosal adenocarcinomas were found and in the third a leiomyosarcoma. In about 30% of the animals treated with MNNG, degenerative liver changes were found, especially single cell and focal necroses, cystic alterations, and bile-duct proliferations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00406933
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  • 5
    Digitale Medien
    Digitale Medien
    Antineoplastic efficacy of melphalan andN-(2-chloroethyl)-N-nitrosocarbamoyl-ω-lysine, in combination with diazoxide or insulin in autochthonous mammary carcinoma of the Sprague-Dawley rat (1990)
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 45-50 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Antineoplastic efficacy ; Melphalan ; Diazoxide ; Insulin ; Mammary carcinoma ; Sprague-Dawley rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The anticancer activity of melphalan andN-(2-chloroethyl)-N-nitrosocarbamoyl-ω-lysine (CNC-ω-Lys), was compared in the autochthonous, methylnitrosourea-induced mammary carcinoma of the Sprague-Dawley rat. In addition, the influence on the therapeutic efficacy of the combination with diazoxide, causing a mild, reversible diabetes, and with insulin was investigated. The comparison of melphalan and CNC-ω-Lys clearly showed the superiority of melphalan. Both compounds displayed a significant tumour inhibition in their medium and the highest dosages in comparison to the untreated control. The combination with diazoxide resulted for almost all groups in an increased tumour inhibition. Only the lowest dose of CNC-ω-Lys + diazoxide did not reduce the tumour volume significantly versus the control group. The combination with insulin, however, resulted in a loss of tumour inhibition compared to the effect of the cytotoxic drug alone, although in these groups, too, a significant decrease of tumour volumes versus controls could be observed. Mortality was within tolerable limits (〈20%) through the treatment period for all experimental groups. Median lifespans were increased in all therapy groups, but no additional benefit could be observed in the combination treatment groups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01612639
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  • 6
    Digitale Medien
    Digitale Medien
    Anticancer-agent-linked phosphonates with antiosteolytic and antineoplastic properties: a promising perspective in the treatment of bone-related malignancies? (1990)
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 341-350 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Bisphosphonates ; Osteosarcoma ; Bone metastasis ; Prophylactic treatment ; Anticancer-agent-linked phosphonates
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Bisphosphonates are compounds with a high affinity for bone and other calcified tissues. They inhibit tumor-induced bone destruction and the associated hypercalcemia by hindering the activity of the osteoclasts. Owing to a long biological half-life of bisphosphonates in the bone, a treatment using a prophylactic regimen seems possible. This paper summarizes preclinical studies with the bisphosphonate 3-amino-1-hydroxypropylidene-1, 1-diphosphonic acid and two methyl derivatives; S-N,N-dimethylamino-1-hydroxypropylidene-1,1-diphosphonic acid and 4-N,N-dimetyhlamino-1-hydroxybutylidene-1, 1-diphosphonic acid with respect to their bone-protecting activity in therapy as well as in prophylaxis. To find substances that are useful for the treatment of primary tumor, as well as bone metastasis, we synthesized and testedcis-diammine[nitrilotris(methylphosphonato) (2-)-O 1 ,N1]platinum(II) andcis-diammine{[bis-(phosphonatomethyl)amino]acetato(2-)-O1, N1} platinum(II), which contain both an osteotropic and an antineoplastic moiety. Experiments were carried out: (a) in the intratibial transplanted Walker carcinosarcoma 256B of the rat, which mimics osteolytic bone metastasis, and (b) in the transplantable osteosarcoma of the rat, which shows a histology and metastatic pattern similar to that found in man. These investigations indicate that it is possible to effect adjuvant therapy of bone metastases by combination of two compounds with different properties into one structure without losing the therapeutic characteristics of the parent compounds. They thus provide evidence that it may be possible to design compounds well suited for the therapeutic or prophylactic treatment of bone-related malignancies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01612916
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  • 7
    Digitale Medien
    Digitale Medien
    Diet and cancer (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 1-10 
    Details
    ISSN: 1432-1335
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Conclusions Since unbalanced diets may increase the carcinogenic risk for certain organs, a balanced form of nutrition is to be recommended from the present point of view. It can also be recommended to avoid hyperalimentation, since this seems to have a positive effect on the cancer mortality risk; furthermore, ideal-weight individuals run a definitely lower risk of suffering a cardiac infarct than overweight individuals. Certain anticancer diets cannot be established. But the intake of juices and salads with a high vitamin C content can inhibit the formation of nitrosamines directly after the intake of food, because the nitrosation is prevented by nitrite interception. Negative influences of diets with a high fiber content are not known. Positive effects are discussed. Since it also prevents obstipation, it can well be recommended. Since dietary habits cannot shortly and easily be changed and changes in nutrition have a considerable impact on the personal quality of living, recommendations favoring certain diets should be given with all due caution. In our opinion the scientific basis for recommendations seems to be too small to justify very restrictive diets for cancer prevention.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00412892
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  • 8
    Digitale Medien
    Digitale Medien
    Chemotherapy of autochthonous leukemias induced by 7,12-dimethylbenz(a)anthracene in long evans rats (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 157-162 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Autochthonous (primary) rat leukemia ; 7,12 Dimethylbenz(a)anthracene ; Chemotherapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A total of 111 autochthonous (primary) acute rat leukemias of the diffuse-hepatic type which had been induced by 7,12-dimethylbenz(a)anthracene were treated with mono- and combination chemotherapy. The survival time of treated rats increased significantly compared to untreated controls. A combination of vincristine (VCR), adriamycin (ADR), and cytosine arabinoside (Ara-C) was superior to a combination of VCR and ADR as well as to a monotherapy with Cyclophosphamide, BCNU, VCR, ADR, and Ara-C.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00405500
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  • 9
    Digitale Medien
    Digitale Medien
    Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats (1981)
    Springer
    Journal of cancer research and clinical oncology 102 (1981), S. 153-157 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Benzo(a)pyrene ; Caffeine ; Oral administration ; Tumors of the forestomach
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In a lifetime experiment benzo(a)pyrene (B(a)P) was administered to Sprague-Dawley rats either as an admixture to the diet or by gavage in an aqueous 1.5% caffeine solution. Dissolved benzo(a)pyrene induced more tumors of the forestomach than undissolved benzo(a)pyrene. The 1.5% caffeine solution (annual dose 27 g/kg) did not exert any carcinogenic activity under the conditions of this bioassay.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00410666
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  • 10
    Digitale Medien
    Digitale Medien
    Chemotherapeutic study on Yoshida sarcoma ascites cells implanted into the glandular stomach of rats (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 250-257 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Yoshida sarcoma ; Glandular stomach ; 5-Fluorouracil, methyl-CCNU, mitomycin C, adriamycin, cytosine arabinoside ; Two-drug combinations ; Sprague-Dawley rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The chemotherapeutic activity of five cytostatic drugs was investigated experimentally in monotherapy and in two-drug combinations, using Yoshida sarcoma cells implanted into the wall of the glandular stomach of Sprague-Dawley rats. In monotherapy, the antibiotic agent mitomycin C and the nitrosourea methyl-CCNU exhibited the highest cytotoxic activity in this tumor model. In combination therapy, the combination of these two drugs was superior to all the other therapeutic schemes tested. In general, the results demonstrate a marked superiority of combination therapy in comparison with monotherapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00395753
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