ISSN:
1420-9071
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The controversial literature reports leave open a question whether apomorphine (APO) and dopamine (DA) share a common receptor? After careful evaluation of the arguments, both for and against, about direct action of APO on DA receptor we propose that rigid molecules like APO holdtrans-cisoid conformation and preferably interact with the pre-synaptic DA receptors while ADTN (2-amino-6,7-dihydroxy, 1,2,3,4-tetrahydronaphthalene) incorporatestrans-transoid conformation and primarily acts on post-synaptic DA receptors. Dopamine, by virtue of its molecular flexibility, can act on both the receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923234
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