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  • 1995-1999  (1,976)
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  • 1995-1999  (1,976)
  • 1990-1994
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  • 1860-1869
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  • 1
    Electronic Resource
    Electronic Resource
    Linkage analysis of candidate myelin genes in familial multiple sclerosis (1999)
    Springer
    Neurogenetics 2 (1999), S. 155-162 
    Details
    ISSN: 1364-6753
    Keywords: Key words Multiple sclerosis ; Genetics ; Myelin basic protein ; Myelin oligodendrocyte glycoprotein ; Proteolipid protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: ABSTRACT Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. A complex genetic etiology is thought to underlie susceptibility to this disease. The present study was designed to analyze whether differences in genes that encode myelin proteins influence susceptibility to MS. We performed linkage analysis of MS to markers in chromosomal regions that include the genes encoding myelin basic protein (MBP), proteolipid protein (PLP), myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMGP), and myelin oligodendrocyte glycoprotein (MOG) in a well-characterized population of 65 multiplex MS families consisting of 399 total individuals, 169 affected with MS and 102 affected sibpairs. Physical mapping data permitted placement of MAG and PLP genes on the Genethon genetic map; all other genes were mapped on the Genethon genetic map by linkage analysis. For each gene, at least one marker within the gene and/or two tightly linked flanking markers were analyzed. Marker data analysis employed a combination of genetic trait model-dependent (parametric) and model-independent linkage methods. Results indicate that MAG, MBP, OMGP, and PLP genes do not have a significant genetic effect on susceptibility to MS in this population. As MOG resides within the MHC, a potential role of the MOG gene could not be excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100480050076
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  • 2
    Electronic Resource
    Electronic Resource
    The neurofibromatoses. An overview (1999)
    Springer
    Italian journal of neurological sciences 20 (1999), S. 89-108 
    Details
    ISSN: 1126-5442
    Keywords: Key words Neurofibromatosis ; Nf1 ; Nf2 ; Mosaic/segmental neurofibromatosis ; Variants ; Classification ; Neurological manifestations ; Genetics ; Childhood ; Adulthood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The last two decades have seen clinical and molecular delineation of the different forms of neurofibromatosis. Differentiation of these forms is not just an academic exercise: their natural history, management and genetic counselling are quite different. Of the numerical classifications of neurofibromatosis proposed in the past, only neurofibromatosis type 1 (Nf1) and neurofibromatosis type 2 (Nf2) are now well delineated clinically and have been shown to be distinct at the molecular level. For both forms of neurofibromatosis, patients with clinical generalised disease have been demonstrated to be mosaic at the molecular level, and features of segmental or mosaic Nf1 and Nf2 have been delineated. Other reported forms of neurofibromatosis are rarer; they include Watson syndrome, hereditary spinal neurofibromatosis, familial intestinal neurofibromatosis, autosomal dominant café-au-lait spots alone, autosomal dominant neurofibromas alone, and schwannomatosis, the latter believed to be a variant of Nf2. Further delineation is neeeded for individuals having overlapping features of Noonan's syndrome and neurofibromatosis (the so-called Noonan/neurofibromatosis syndrome) and the syndrome of “multiple naevi, multiple schwannomas and multiple vaginal leiomyomas”. In this article we review the forms of neurofibromatosis which we believe are true clinical entities. Particular attention is given to the neurological manifestations of neurofibromatosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100720050017
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  • 3
    Electronic Resource
    Electronic Resource
    Insulin resistance and impaired insulin secretion due to phosphofructo-1-kinase-deficiency in humans (1999)
    Springer
    Journal of molecular medicine 77 (1999), S. 96-103 
    Details
    ISSN: 1432-1440
    Keywords: Key words Diabetes ; Genetics ; Phosphofructokinase ; Glycogenosis ; NIDDM ; PFK
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The etiology of non-insulin-dependent diabetes mellitus (NIDDM) is usually explained as a combination of peripheral insulin resistance and impaired beta-cell function. Phosphofructo-1-kinase (PFK1) is a rate limiting enzyme in glycolysis, and its muscle subtype (PFK1-M) deficiency leads to an autosomal recessively inherited disorder known as glycogenosis type VII or Tarui’s disease. It was evaluated whether PFK1-M deficiency leads to NIDDM in humans. A core family of four was evaluated for PFK1-M deficiency by DNA- and enzyme-activity-analyses. All members underwent oral and intravenous glucose tolerance test (oGTT/ivgtt), as well as an insulin sensitivity test (IST) using octreotide. Results: Father (46 years, BMI 22.4 kg/m2) and older son (19 years, BMI 17.8 kg/m5) showed homozygous PFK1-M deficiency, while mother (47 years, BMI 28.4 kg/m5) and younger son (13 years, BMI 16.5 kg/m5) were shown to be heterozygously PFK1-M-deficient on enzyme activity levels. DNA analysis revealed an exon 5-missense-mutation at one allele of all four members, and an exon 22-frameshift-mutation at the other allele of the two homozygously affected individuals. By oGTT the father showed impaired glucose tolerance, and the mother clinical diabetes. By ivGTT both parents and the older son had a decreased first phase insulin secretion, and a diminished glucose disappearance rate. The IST showed marked insulin resistance in both parents and the older son, and moderate resistance in the younger son, previously not described. Conclusion: PFK1-M-deficiency leads to a metabolic state typical for early NIDDM in homozygously affected humans, especially concerning insulin resistance and loss of first phase beta-cell insulin secretion, and may contribute to the manifestation of NIDDM in a subgroup of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050311
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  • 4
    Electronic Resource
    Electronic Resource
    Erbliche Ursachen und Risikofaktoren der Alzheimer-Krankheit (1999)
    Springer
    Der Nervenarzt 70 (1999), S. 195-205 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Alzheimer-Krankheit ; Genetik ; Risikofaktoren ; Genetische Beratung ; Key words Alzheimer’s disease ; Genetics ; Risk factors ; Genetic counseling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A multifactorial etiology underlies the majority of cases of Alzheimer’s disease (AD). Both ill-defined environmental and genetic factors contribute to the development of the disease. Allele ɛ4 of ApoE is a genetic risk factor. Its presence increases the risk of developing AD. However, presence of e4 is neither necessary nor sufficient for the disease to arise. Apart from the common multifactorial forms of the disease, there are rare variants which are inherited as Mendelian traits. To date three genes are known that can be mutated in these rare forms of AD. Of these, mutations in the gene presenilin 1 on chromosome 14 are most frequent. In addition, mutations in the gene presenilin 2 on chromosome 1 and in the amyloid precursor protein gene (APP on chromosome 21) occur in autosomal dominant AD. This article reviews our present knowledge of the genetics of AD and discusses its relevance for patients with AD and their relatives.
    Notes: Zusammenfassung Der Großteil der Fälle von Alzheimer-Krankheit (AK) hat eine multifaktorielle Ätiologie. Das bedeutet, bisher nicht genauer bekannte Umwelteinflüsse und genetische Faktoren spielen bei der Entwicklung der Krankheit eine wesentliche Rolle. Von seiten der Genetik unterscheidet man bei der AK gegenwärtig genetische Risikofaktroren und Mutationen. Der einzige bisher gesicherte genetische Risikofaktor ist das Allel ɛ4 des Gens für Apolipoprotein E auf Chromosom 19. Dieses Allel erhöht die Wahrscheinlichkeit, an der AK zu erkranken, ist jedoch weder eine notwendige noch eine hinreichende Bedingung. Neben den häufigen Formen mit multifaktorieller Ätiologie kommen seltene Varianten der Krankheit vor, die nach Mendelschen Regeln vererbt werden. Bisher sind 3 Gene bekannt, die bei diesen seltenen, in der Regel früh auftretenden und autosomal dominant vererbten Formen mutiert sein können. Am häufigsten findet sich bei den autosomal-dominanten Fällen eine Mutation im Gen präsenilin 1 auf Chromosom 14, seltener liegen Mutationen im Gen präsenilin 2 auf Chromosom 1 und im Gen des Amyloid- Vorläuferproteins auf Chromosom 21 vor. In diesem Beitrag geben wir eine Übersicht über gegenwärtige Befunde zur Genetik der AK und diskutieren die Bedeutung dieses Wissens für Patienten und deren Verwandte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050423
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  • 5
    Electronic Resource
    Electronic Resource
    Genetik schizophrener Störungen Neuere Konzepte und Befunde (1999)
    Springer
    Der Nervenarzt 70 (1999), S. 955-969 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Schizophrenie ; Genetik ; Schizophrenes Spektrum ; Kopplungsuntersuchungen ; Assoziationsuntersuchungen ; Key words Schizophrenia ; Genetics ; Schizophrenia spectrum ; Linkage studies ; Association studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Schizophrenia is a genetic complex disease as it does not follow monogenic transmission while non-familial environmental factors have a strong additional impact. A heterogenous, continuous phenotype is transmitted in families which can now be more precisely characterized. Genes coding for proteins with presumed pathophysiological relevance are apparently not playing a major causal role. However, in the last three years several (currently seven) candidate regions have been identified in a replicable manner by linkage studies. These regions are likely to host susceptibility genes for schizophrenia, but none of them has been identified up to now. Given these findings, polygenic transmission has now become very likely. The candidate regions are currently being narrowed down by various promising techniques.
    Notes: Zusammenfassung Die Schizophrenie gehört zu den genetisch komplexen Erkrankungen, die keinem monogenen Erbgang folgen und bei denen auch nichtfamiliäre Umgebungsfaktoren eine wichtige Rolle spielen. Dabei wird intrafamiliär ein heterogener, quantitativ variierender Phänotyp übertragen, der zunehmend genauer charakterisiert werden kann. Keines der bekannten Gene mit vermuteter pathophysiologischer Relevanz spielt nach den bisherigen Erkenntnissen eine substantielle Rolle. In den vergangenen drei Jahren ist es aber erstmals durch Kopplungsuntersuchungen gelungen, mehrere replizierbare Kandidatenregionen (derzeit sieben) auf dem Genom zu identifizieren, in denen vermutlich Suszeptibilitätsgene für Schizophrenie liegen. Keines dieser Gene wurde jedoch bislang identifiziert. Mit diesen Befunden ist eine polygene Übertragung der Schizophrenie sehr wahrscheinlich geworden. Verschiedene Techniken zur Eingrenzung der Kandidatenregionen werden derzeit erfolgreich angewandt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050524
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  • 6
    Electronic Resource
    Electronic Resource
    A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy (1999)
    Springer
    Acta neuropathologica 98 (1999), S. 62-77 
    Details
    ISSN: 1432-0533
    Keywords: Key words Frontotemporal dementia ; Genetics ; Progressive supranuclear palsy ; Tauopathy ; Exon ; amplifcation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently intronic and exonic mutations in the Tau gene have been found to be associated with familial neurodegenerative syndromes characterized not only by a predominantly frontotemporal dementia but also by the presence of neurological signs consistent with the dysfunction of multiple subcortical neuronal circuitries. Among families, the symptomatology appears to vary in quality and severity in relation to the specific Tau gene mutation and often may include parkinsonism, supranuclear palsies, and/or myoclonus, in addition to dementia. We carried out molecular genetic and neuropathological studies on two patients from a French family presenting, early in their fifth decade, a cognitive impairment and supranuclear palsy followed by an akinetic rigid syndrome and dementia. The proband died severely demented 7 years after the onset of the symptoms; currently, his brother is still alive although his disease is progressing. In both patients, we found a Tau gene mutation in exon 10 at codon 279, resulting in an asparagine to lysine substitution (N279K). Neuropathologically, widespread neuronal and glial tau accumulation in the cortex, basal ganglia, brain stem nuclei as well as in the white matter were the hallmark of the disease. These deposits were shown by immunohistochemistry and immunoelectron microscopy, using a battery of antibodies to phosphorylation-dependent and phosphorylation-independent epitopes present in multiple tau regions. In the neocortex, tau-immunopositive glial cells were more numerous than immunopositive neurons; the deeper cortical layers as well as the white matter adjacent to the cortex contained the largest amount of immunolabeled glial cells. In contrast, some brain stem nuclei contained more neurons with tau deposits than immunolabeled glial cells. The correlation of clinical, neuropathological and molecular genetic findings emphasize the phenotypic heterogeneitiy of diseases caused by Tau gene mutations. Furthermore, to test the effect of the N279K mutation and compare it with the effect of the P301L exon 10 mutation on alternative splicing of Tau exon 10, we used an exon amplification assay. Our results suggest that the N279K mutation affects splicing similar to the intronic mutations, allowing exon 10 to be incorporated more frequently in the Tau transcript.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051052
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  • 7
    Electronic Resource
    Electronic Resource
    Management of mantle cell lymphoma (1999)
    Springer
    Annals of hematology 78 (1999), S. 485-494 
    Details
    ISSN: 1432-0584
    Keywords: Key words Mantle cell lymphoma ; Classification ; Pathology ; Prognosis ; Immunology ; Genetics ; Antineoplastic agents ; Combined ; Therapeutic use ; Radiotherapy ; Hematopoietic stem cell transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050545
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  • 8
    Electronic Resource
    Electronic Resource
    Why is acute leukemia more common in males? A possible sex-determined risk linked to the ABO blood group genes (1999)
    Springer
    Annals of hematology 78 (1999), S. 233-236 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute leukemia ; Genetics ; Sex ; ABO Blood group
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Acute leukemia is more common in males at almost every age, and this fact remains unexplained. A study was carried out in northeast peninsular Malaysia, where the population is predominantly Malay, to examine whether there was a difference in ABO blood group distribution between males and females with acute leukemia (AL). The ABO blood groups of 109 male and 79 female patients with AL (98 ALL, 90 AML) were compared with those of 1019 controls. In the control population, 39.7% were group O. Among males with AL, 39.4% were group O, whereas among females with AL, the proportion was 24.1% (p=0.03). The same trend to a lower proportion of group O among females was seen if the group was divided into adult/pediatric or lymphoblastic/myeloblastic groups, though these differences were not statistically significant. If these findings can be confirmed, they suggest the presence of a "sex-responsive" gene near to the ABO gene locus on chromosome 9, which relatively protects group O women against AL, at least in our population. The existence of such a gene might also partly explain why acute leukemia, and possibly other childhood cancers, are more common in males.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050507
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  • 9
    Electronic Resource
    Electronic Resource
    Analysis of potential phosphorylation sites in human T cell leukemia virus type 1 Tax (1999)
    Springer
    Journal of biomedical science 6 (1999), S. 206-212 
    Details
    ISSN: 1423-0127
    Keywords: Tax ; HTLV-1 ; Trans-activation ; Phosphorylation ; Mutagenesis ; Transcription ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The human T cell leukemia virus type 1 (HTLV-1) Tax is a phosphoprotein, however, the contribution of phosphorylation to Tax activity is unknown. Previous studies have shown that phosphorylation of Tax occurs on serine residue(s), within one tryptic fragment, in response to 4β-phorbol-12β-myristate-13α-acetate, in both mouse and human cells. Studies were conducted in multiple cell lines to identify the specific phosphorylated serines as a prelude to functional analysis. The phosphorylation pattern of Tax was found to be different in 293T and COS-7 cells in comparison with MT-4 and Px-1 cells. However, one tryptic fragment remained consistent in comigration analyses among all cell lines. Using selected Tax serine mutants a tryptic fragment containing a serine at residue 113 believed to be the site of phosphorylation of Tax did not comigrate with the common phosphorylated tryptic fragment. Analysis of selected Tax mutants for ability totrans-activate the cytomegalovirus promoter demonstrated mutation of serine 77 to alanine reducedtrans-activation by 90% compared to wild-type Tax. However, examination of the phosphorylation pattern of the serine 77 mutant demonstrated that it is not the site of phosphorylation. These studies demonstrate the importance of using relevant cell lines to characterize the role of phosphorylation in protein function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02255904
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  • 10
    Electronic Resource
    Electronic Resource
    Pathologie der Rhabdo- myosarkome des Kindes- und Adoleszentenalters Ein Bericht des Kindertumorregisters bei der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) (1999)
    Springer
    Der Pathologe 20 (1999), S. 87-97 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Rhadomyosarkom ; Klassifizierung ; Immunhistochemie ; Genetik ; Prognose ; Key words Rhabdomyosarcoma ; Classification ; Immunohistochemistry ; Genetics ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Rhabdomyosarcoma (RMS) is the most important and a very heterogeneous group of malignant soft tissue tumors of childhood and adolescence.The two major subtypes (embryonal and alveolar) share a common myogenic differentiation, but seem to be histogenetically not related. The so-called ’International Classification of Rhabdomyosarcoma’ includes, besides the two major subtypes, the botryoid and leiomyomatous subtypes of embryonal RMS which are associated with a better prognosis and are treated less aggressively according to current protocols. In addition, the solid variant of alveolar RMS is included in the alveolar group of RMS. The identification of the various subtypes is necessary and important because the treatment with the current protocols is also related to histology. Using conventional stains and immunohistochemistry, these subtypes are distinguishable. Genetic analysis can be helpful in the demonstration of t(2;13) or t(1;13) translocations in alveolar RMS. The identification of alveolar RMS with t(1;13) translocation might become important in the future, because this type of translocation seems to be related to a better prognosis as compared to tumors with a t(2;13) translocation.
    Notes: Zusammenfassung Rhabdomyosarkome stellen eine heterogene Gruppe von ganz verschiedenartigen, histogenetisch wohl nicht zusammengehörenden Tumoren dar. Nach der heute verwendeten „Internationalen Klassifikation” der Rhabdomyosarkome werden neben der Unterteilung in embryonalen und alveoläre Rhabdomyossarkome auch Subtypen des embryonalen RMS identifiziert (botryoider und leiomyomatöser Subtyp), die durch eine günstigere Prognose und durch die Notwendigkeit einer weniger aggressive Therapie gekennzeichnet sind. Durch Einsatz von verschiedenen histologischen und immunhistochemischen Färbungen ist die Identifizierung der verschiedenen Typen der RMS heute möglich und auch zwingend notwendig, da die einzelnen Entitäten nach ganz unterschiedlichen Therapieprotokollen behandelt werden. Der Nachweis typischer molekulargenetischer Veränderungen kann in der Unterscheidung insbesondere von embryonalen und alveolären RMS hilfreich sein. In der Regel ist die Abgrenzung zwischen diesen beiden Entitäten auch an konventionell gefärbten Schnittpräparaten möglich. Die Identifizierung von alveolären RMS mit einer t(1;13)-Translokation könnte in Zukunft eine große Bedeutung haben, da diese genetische Veränderung möglicherweise mit einer günstigeren Prognose assoziert sein könnte als die t(2;13)-Translokation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050326
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  • 11
    Electronic Resource
    Electronic Resource
    Clinical relevance of monosomy 22q11.2 in children with pulmonary atresia and ventricular septal defect (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 302-307 
    Details
    ISSN: 1432-1076
    Keywords: Key words Congenital heart disease ; Pulmonary atresia and ventricular septal defect ; Genetics ; Monosomy 22q11.2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of our study was to describe the prevalence and the clinical spectrum of monosomy 22q11.2 in a population of patients with pulmonary atresia and ventricular septal defect. We examined all 44 patients with this conotruncal cardiac malformation who presented to our institution from January 1994 until December 1997. The type of collateral lung perfusion was recorded including anomalies of the pulmonary arteries as well as facial and immunological abnormalities. Molecular-cytogenetic testing for a 22q11.2 microdeletion was performed using the probes D22S75 and cHKAD26. Statistical differences were evaluated with the Fisher's Exact Test. Monosomy 22q11.2 was present in ten children (23%) with major aortopulmonary collateral arteries (group 1). The remaining 13 children (29%) with major aortopulmonary collateral arteries (group 2) and all 21 children (48%) with ductus arteriosus (group 3) were negative for this microdeletion. All children in group 1 had facial anomalies, six had mild immunological abnormalities including decreased CD 4+ or CD 8+ cells. Anomalies of the pulmonary vascular bed were significantly more frequent in children of group 1 (9/10) than in children of group 2 (4/13) or group 3 (0/21). Due to these pulmonary vascular anomalies, corrective surgery had been accomplished in fewer children with monosomy 22q11.2 (none in group 1) as compared to 7/13 children in group 2 and 14/21 children in group 3. Conclusion In children with pulmonary atresia and ventricular septal defect, monosomy 22q11.2 is preferentially associated with major aortopulmonary collateral arteries. Due to the higher incidence of pulmonary arterial abnormalities, successful surgical repair will require a different therapeutic approach in most patients with this microdeletion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051077
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  • 12
    Electronic Resource
    Electronic Resource
    Controlling septation in fission yeast: finding the middle, and timing it right (1999)
    Springer
    Current genetics 35 (1999), S. 571-584 
    Details
    ISSN: 1432-0983
    Keywords: Key words Cytokinesis ; Kinase ; Mitosis ; Schizosaccharomyces pombe ; Cell division ; Phosphatase ; Mutant ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The fission yeast Schizosaccharomyces pombe provides a simple eukaryotic model for the study of cytokinesis. S. pombe cells are rod-shaped, grow mainly by elongation at their tips, and divide by binary fission after forming a centrally placed division septum. Analysis of mutants has begun to shed light upon how septum formation and cytokinesis are regulated both spatially and temporally. Some of the proteins involved in these events have been functionally conserved throughout eukaryotic evolution, suggesting that aspects of this control will be common to all eukaryotic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002940050455
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  • 13
    Electronic Resource
    Electronic Resource
    Polymorphisms in the glutamate transporter gene EAAT2 in European ALS patients (1999)
    Springer
    Journal of neurology 246 (1999), S. 1140-1144 
    Details
    ISSN: 1432-1459
    Keywords: Key words Amyotrophic lateral sclerosis ; Genetics ; Glutamate transporter gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder characterised by degeneration of upper and lower motor neurons. Whilst the primary pathogenic trigger is unknown in most cases, evidence is mounting to implicate a role for glutamate-mediated neurotoxicity in the disorder. Recent studies have shown reduced levels of the mainly astroglial glutamate transporter EAAT2 in ALS motor cortex and spinal cord and multiple abnormal EAAT2 mRNA species in ALS brain tissue. One cause of the low EAAT2 levels may be that point mutations in the EAAT2 gene, EAAT2, result in an abnormal unstable protein. To test this hypothesis we analysed EAAT2 in 128 sporadic and 23 familial European ALS cases. No variants within the coding sequence of EAAT2 to affect the protein sequence nor in the consensus splice sites of the flanking intronic sequences were found in any cases, similar to findings in other reports. Frequent polymorphisms within the flanking intronic sequences of both exons 2 and 4 were seen but at similar frequencies in controls. Mechanisms other than mutations within the coding region of EAAT2 must therefore be responsible for the low levels of EAAT2 seen in most cases of ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050532
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  • 14
    Electronic Resource
    Electronic Resource
    Etiology of the inflammatory bowel diseases (1999)
    Springer
    International journal of colorectal disease 14 (1999), S. 2-9 
    Details
    ISSN: 1432-1262
    Keywords: Key words Inflammatory bowel disease ; Crohn's disease ; Ulcerative colitis ; Epidemiology ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Inflammatory bowel diseases (IBD) are complex disorders. While the exact etiology of these diseases remains unknown, recent progress in the epidemiology and genetics of IBD has clearly demonstrated both environmental and genetic factors to play a role in the development of the disease, and it is expected that some risk factors are common for both Crohn's disease (CD) and ulcerative colitis (UC). The environmental factor(s) are associated with the Western way of life in the second half of the twentieth century. Cigarette smoking is presently the best known environmental factor. However, the effect of tobacco is opposite in CD and UC. A familial history of IBD is the most important risk factor for developing the disease, suggesting a genetic predisposition to IBD. This hypothesis has recently been confirmed by the localization of at least two susceptibility loci on chromosomes 12 and 16. These genes seem to play a role in both CD and UC. They must now to be identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003840050175
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  • 15
    Electronic Resource
    Electronic Resource
    Craniosynostosis: from a clinical description to an understanding of bone formation of the skull (1999)
    Springer
    Child's nervous system 15 (1999), S. 676-680 
    Details
    ISSN: 1433-0350
    Keywords: Key words Craniosynostosis ; Genetics ; FGFR ; Msx2 ; Development ; Skull
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The genetic studies of syndromic craniosynostoses lead to the characterisation of genes that regulate the correct development of the bones of the skull. From these studies, it appears that FGF/FGFR signalling has a crucial role in this problem. Numerous mutations affecting the genes coding for FGFR1, 2 or 3 are responsible for these syndromes. It is interesting to note that some identical mutations produced various different phenotypes, suggesting that other genes modulate the phenotypic expressivity. The other involved genes in these syndromes code for such proteins as Msx2 or Twist that interact in the cellular pathways responsible for FGF action. From these genetic studies, it is now important to establish the role of these proteins during the development of the skull. Msx2 plays a repressive role in osteogenesis, whereas FGFRs act as promoting proteins. In the near future, it will be very important to improve our understanding of these phenomena in order to test specific treatments to prevent the development of such syndromes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050457
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  • 16
    Electronic Resource
    Electronic Resource
    Early diagnosis and the clinical genetics of Alzheimer’s disease (1999)
    Springer
    Journal of neurology 246 (1999), S. 69-72 
    Details
    ISSN: 1432-1459
    Keywords: Key words Alzheimer’s disease ; Genetics ; Genetic counseling ; Predictive testing ; Diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Alzheimer’s disease (AD) has a significant genetic background manifested as autosomal dominant inheritance in some early-onset families and as familial risk in late-onset cases. Three genes responsible for early-onset autosomal dominant AD have been identified, and one gene, apolipoprotein E, has been confirmed as a susceptibility gene for late-onset forms of the disorder. These findings raise the possibility of genetic testing, either for early diagnosis or prediction. For early-onset autosomal dominant AD genetic testing will have a limited but useful role in confirming diagnosis in established cases and in predictive counselling for relatives; a situation analogous to that for Huntington’s disease. For late-onset AD significant problems remain to be overcome before the advances in molecular genetics have a direct clinical application
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050310
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  • 17
    Electronic Resource
    Electronic Resource
    Mitochondrial DNA mutation at np 3243 in a family with maternally inherited diabetes mellitus (1999)
    Springer
    Acta diabetologica 36 (1999), S. 163-167 
    Details
    ISSN: 1432-5233
    Keywords: Key words Mitochondrial DNA ; Genetics ; Maternally inherited diabetes mellitus ; Deafness ; np 3243 mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mitochondrial DNA (mtDNA) gene defects may play a role in the development of maternally inherited diabetes mellitus and deafness (MIDD). A family from Southern Italy who showed maternal transmission of type 2 diabetes mellitus with three individuals affected is described. A 10.4 kb deletion and mutations at nucleotide positions (np) 3243, 7445 and 11778 in the mtDNA of six relatives were sought. The mitochondrial np 3243 mutation of the tRNA Leu (UUR) gene was identified in a boy affected by optic atrophy and mental retardation, as well as in his diabetic mother. No other mutations or deletions were found. Our study points out the variable phenotypic expression of the np 3243 mtDNA mutation. This may suggest the presence of other mitochondrial or nuclear mutations required to modulate the phenotype. A clinical and metabolic follow-up of all family members was necessary to understand the role of the np 3243 mutation, especially in one child affected by optic atrophy and mental retardation. Further studies will be aimed at investigating the prevalence of mutations and deletions of mtDNA in type 2 diabetes mellitus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005920050161
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  • 18
    Electronic Resource
    Electronic Resource
    Self-incompatibility in passion fruit: evidence of two locus genetic control (1999)
    Springer
    Theoretical and applied genetics 98 (1999), S. 564-568 
    Details
    ISSN: 1432-2242
    Keywords: Key words Passiflora ; Self-incompatibility ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The self-incompatibility in yellow passion fruit was previously described as homomorphic sporophytic with monofactorial inheritance. Five progenies were obtained by bud-selfing. The plants of these progenies were selfed, reciprocally crossed within each progeny and crossed with known incompatible phenotypes to identify their phenotypic group. Fruit set was evaluated at the 7th day after pollination. Two progenies consisted of two self-incompatible groups, the other three formed three suck groups. The groups were identified as S1, S2, S3, S4, S5 and S6. The results provide evidence that the self-incompatibility of passion fruit is controlled by two loci, the S-gene and another, whose expression needs to be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051105
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  • 19
    Electronic Resource
    Electronic Resource
    AC/GT and AG/CT microsatellite repeats in peach [Prunus persica (L) Batsch]: isolation, characterisation and cross-species amplification in Prunus (1999)
    Springer
    Theoretical and applied genetics 99 (1999), S. 65-72 
    Details
    ISSN: 1432-2242
    Keywords: Key words Simple sequence repeat (SSR) ; Microsatellites ; Molecular markers ; Genetics ; Fingerprinting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  We report the sequences of 17 primer pairs of microsatellite loci, which we have cloned and sequenced from two genomic libraries of peach [Prunus persica (L) Batsch] ‘Redhaven’, enriched for AC/GT and AG/CT repeats respectively. For ten of these microsatellite loci we were able to demonstrate Mendelian inheritance in a segregating back-cross population; the remainder did not segregate. The polymorphism of the microsatellites was evaluated in a panel of ten peach genotypes, including true-to-type peaches, nectarines and one canning-peach. Fifteen microsatellites (88%) were polymorphic showing 2–4 alleles each. The mean heterozygosity, averaged over all loci, was 0.32 and significantly higher than that reported in the literature for isozymes and molecular markers, such as RFLPs and RAPDs. We have also assayed the cross-species transportability and found that ten microsatellite (59%) gave apparently correct amplification in all Prunus species surveyed, namely P. domestica (European plum), P. salicina (Japanese plum), P. armeniaca (apricot), P. dulcis (almond), P. persica var. vulgaris (peach), P. persica var. laevis (nectarine), P. avium (sweet cherry) and P. cerasus (sour cherry), with three of them also being amplified in Malus (apple). The remaining microsatellites gave less-extensive amplification. Because of their appreciable polymorphism and wide cross-species transportability, most of these new markers can be integrated into the linkage maps which are currently being constructed in peach, as well as in other stone fruit crops, such as almond, apricot, cherry and plum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051209
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  • 20
    Electronic Resource
    Electronic Resource
    A stylar ribonuclease assay to detect self-compatible seedlings in almond progenies (1999)
    Springer
    Theoretical and applied genetics 99 (1999), S. 800-810 
    Details
    ISSN: 1432-2242
    Keywords: Key words Almond ; Compatibility ; Genetics ; Prunus dulcis ; Ribonucleases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Six almond progenies, each the product of a cross between a self-compatible and a self-incompatible parent, were analysed for stylar ribonucleases. Proteins were extracted and separated using non-equilibrium pH gradient electrofocusing (NEPHGE), and the gels were stained for ribonuclease activity. Most seedlings showed either two principal bands, interpreted as corresponding to two incompatibility alleles, or a single band. The seedlings were also bagged in the field at flowering time to determine fruit set after selfing, and some were also examined for the growth of pollen-tubes in selfed styles using UV fluorescence microscopy. With very few exceptions, those seedlings showing single-banded zymograms were found to be self-compatible according to field and microscope studies, and those with two bands were found to be self-incompatible. We conclude that the allele for self-compatibility in almond does not code for ribonuclease activity and that the ribonuclease isoenzyme assay is a convenient technique for predicting self-compatibility in segregating progenies. A novel band in two derivatives of ’Ferrastar’ was ascribed to a new incompatibility allele, S 10 .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051299
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  • 21
    Electronic Resource
    Electronic Resource
    Division of labor in a dynamic environment: response by honeybees (Apis mellifera) to graded changes in colony pollen stores (1999)
    Springer
    Behavioral ecology and sociobiology 46 (1999), S. 171-179 
    Details
    ISSN: 1432-0762
    Keywords: Key words Honeybee ; Apis mellifera ; Division of labor ; Genetics ; Pollen foraging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A fundamental requirement of task regulation in social groups is that it must allow colony flexibility. We tested assumptions of three task regulation models for how honeybee colonies respond to graded changes in need for a specific task, pollen foraging. We gradually changed colony pollen stores and measured behavioral and genotypic changes in the foraging population. Colonies did not respond in a graded manner, but in six of seven cases showed a stepwise change in foraging activity as pollen storage levels moved beyond a set point. Changes in colony performance resulted from changes in recruitment of new foragers to pollen collection, rather than from changes in individual foraging effort. Where we were able to track genotypic variation, increases in pollen foraging were accompanied by a corresponding increase in the genotypic diversity of pollen foragers. Our data support previous findings that genotypic variation plays an important role in task regulation. However, the stepwise change in colony behavior suggests that colony foraging flexibility is best explained by an integrated model incorporating genotypic variation in task choice, but in which colony response is amplified by social interactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002650050607
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  • 22
    Electronic Resource
    Electronic Resource
    Preliminary report on the Mount Sinai Hospital Inflammatory Bowel Disease Genetics Project (1997)
    Springer
    Diseases of the colon & rectum 40 (1997), S. 553-557 
    Details
    ISSN: 1530-0358
    Keywords: Inflammatory bowel disease ; Crohn's disease ; Ulcerative colitis ; Genetics ; Family history
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract BACKGROUND: Although the etiology of inflammatory bowel disease (IBD) is unknown, there is increasing evidence that genetic predisposition plays a major etiologic role. To provide the framework for gene identification using a positional cloning approach, ascertainment of families with multiple affected members and careful documentation of pedigrees are essential. Objective: To report the initial findings of the IBD Genetics Project of the Mount Sinai Hospital IBD Research Unit. METHODS: All records of patients with ulcerative colitis and Crohn's disease followed at the Mount Sinai Hospital IBD Unit were reviewed. A questionnaire was sent to all patients to ascertain those with a family history of IBD. Patients with a presumed family history were contacted by a research assistant, and after confirmation of diagnosis, relevant clinical information, pedigrees, and consent to contact family members were obtained. Blood for DNA and cell line preparation were collected from affected and nonaffected family members. RESULTS: Of 2,504 patients registered in the IBD database, 231 (9.2 percent) were found to have an affected family member: 96 of 964 (10 percent) with Crohn's disease (CD) and 135 of 1,540 (8.8 percent) with ulcerative colitis (UC). A mean of 2.4 family members were affected. In families in which the proband had CD, 82.3 percent had only two affected family members, 78.1 percent had only family members affected with CD, and 82.3 percent had only first-degree family members affected. In families in which the proband had UC, 70.4 percent had only two affected family members, 71.1 percent had only family members affected with UC, and 65.2 percent had only first-degree family members affected. In the 231 families, there were 103 sibling pairs: 46 percent with CD, 28 percent with UC, and 26 percent with CD/UC. CONCLUSION: These data suggest that approximately 10 percent of IBD patients have affected family members, with the rate being similar in UC and CD. Future research is directed to genome scanning and linkage analysis in this cohort of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02055377
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  • 23
    Electronic Resource
    Electronic Resource
    Genetic control of Interleukin 12 responsiveness: implications for disease pathogenesis (1997)
    Springer
    Journal of molecular medicine 75 (1997), S. 502-511 
    Details
    ISSN: 1432-1440
    Keywords: Key words T helper 1/T helper 2 ; Genetics ; Interleukin 12 ; Allergy ; Autoimmunity ; Leishmania
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We examined the effect of genetic background on Th1/Th2 development. We discuss data demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) responsiveness and the potential implications for disease progression in murine experimental leishmaniasis. Genetic analysis of the differential control of IL-12 responsiveness led to the identification of a controlling locus on the middle portion of murine chromosome 11. This genetic region (or its human counterpart, 5q31) has been associated with increased disease susceptibilities for several atopic, infectious, and autoimmune disorders. We discuss potential roles for genetic control of IL-12 responsiveness in the development of these diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050135
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  • 24
    Electronic Resource
    Electronic Resource
    Familial Hodgkin's disease: a disease of young adulthood? (1997)
    Springer
    Annals of hematology 74 (1997), S. 131-134 
    Details
    ISSN: 1432-0584
    Keywords: Key words Hodgkin's disease ; Sex ; Age ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Familial Hodgkin's disease (FHD) is estimated to represent approximately 4.5% of all cases of Hodgkin's disease (HD). Shared environmental factors, such as Epstein-Barr virus and other viral agents, and genetic determinants have all been proposed to explain familial aggregation of HD. In order to compare the characteristic features of FHD with those of the much more common sporadic form, we reviewed 28 articles on FHD, published between 1972 and 1995, and analyzed in further detail data from 18 papers, reporting on a total of 328 patients. The male-to-female ratio of the FHD population examined was 1.5, similar to that reported for sporadic HD, and lower than the one suggested for FHD by some authors. On the other hand, a significant difference was found between sporadic and familial HD according to age at diagnosis; that is, only one major peak between 15 and 34 years was present in the group of patients with FHD. Further investigation of FHD in young adulthood may provide insight into the hypothesis of a genetic or infectious etiology of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050270
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  • 25
    Electronic Resource
    Electronic Resource
    Genetics and cytology of a new genic male-sterile soybean [Glycine max (L.) Merr.] (1997)
    Springer
    Sexual plant reproduction 10 (1997), S. 13-21 
    Details
    ISSN: 1432-2145
    Keywords: Key words Soybean ; Male sterility ; Genetics ; Callase ; Callose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Genetic and cytological studies were conducted with a new male-sterile, female-fertile soybean [Glycine max (L.) Merr.] mutant. This mutant was completely male sterile and was inherited as a single-recessive gene. No differences in female or male gamete transmission of the recessive allele were observed between reciprocal cross-pollinations in the F1 or F2 generations. This mutant was not allelic to any previously identified soybean genic male-sterile mutants: ms1, ms2, ms3, ms4, ms5, or ms6. No linkage was detected between sterility and flower color (W1 locus), or between sterility and pubescence color (T1 locus). Light microscopic and cytological observations of microsporogenesis in fertile and sterile anthers were conducted. The structure of microspore mother cells (MMC) in male-sterile plants was identical to the MMCs in male-fertile plants. Enzyme extraction analyses showed that there was no callase activity in male-sterile anthers, and this suggests that sterility was caused by retention of the callose walls, which normally are degraded around tetrads at the late tetrad stage. The tapetum from male-sterile anthers also showed abnormalities at the tetrad stage and later stages, which were expressed by an unusual formation of vacuoles, and by accumulation of densely staining material. At maturity, anthers from sterile plants were devoid of pollen grains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004970050062
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  • 26
    Electronic Resource
    Electronic Resource
    Effect of naltrexone on subjective alcohol response in subjects at high and low risk for future alcohol dependence (1997)
    Springer
    Psychopharmacology 129 (1997), S. 15-22 
    Details
    ISSN: 1432-2072
    Keywords: Key words Naltrexone ; Alcohol ; Genetics ; Social drinkers ; Family history of alcoholism ; Biphasic Alcohol Effects Scale
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated specific subjective effects of naltrexone pretreatment or placebo during various intervals on the breath alcohol level (BAL) curve in nonalcoholic volunteers. Fifteen high-risk (social drinkers with an alcoholic father) and 14 low-risk (no alcoholic relatives in at least two generations) subjects were tested in a double-blind, placebo-controlled study of the effects of 50 mg oral naltrexone on response to a moderate dose of alcohol. Dependent measures included subjective stimulation and sedation subscales from the Biphasic Alcohol Effects Scale (BAES) and mood subscales from the Profile of Mood States (POMS). At rising BALs, high-risk subjects showed a naltrexone-related attenuation of BAES stimulation. This effect was not evident in low-risk subjects, who directionally showed the opposite effect, although nonsignificant. For both groups, there were no significant naltrexone-related effects for BAES sedation; however, naltrexone did affect several POMS scales on alcohol response, such as decreased vigor, and increased fatigue, tension, and confusion. Confusion was significantly elevated for the high-risk group during rising BALs of the naltrexone session. The results suggest a differential response to naltrexone, based on paternal history of alcoholism and level of stimulation experienced during alcohol drinking.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050156
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  • 27
    Electronic Resource
    Electronic Resource
    Mitochondrial DNA polymorphisms in pathologically proven Parkinson’s disease (1997)
    Springer
    Journal of neurology 244 (1997), S. 262-265 
    Details
    ISSN: 1432-1459
    Keywords: Key words Parkinson’s disease ; Genetics ; Mitochondrial DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To date, five single base pair changes of the mitochondrial DNA have been reported to occur either exclusively or with increased frequency in Caucasian patients with Parkinson’s disease (PD) and it has been postulated that these mutations might be causally related to the observed inhibition of mitochondrial respiratory chain function in PD. To evaluate these findings, we analysed the frequency of all five polymorphisms in 100 cases of pathologically proven cases of PD. We were either unable to detect the previously described polymorphisms in our series or found them to be present with the same frequency among controls. Our data do not support the hypothesis of an involvement of the mitochondrial DNA in the pathogenesis of PD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050082
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  • 28
    Electronic Resource
    Electronic Resource
    Genetics, haloperidol-induced catalepsy and haloperidol-induced changes in acoustic startle and prepulse inhibition (1997)
    Springer
    Psychopharmacology 134 (1997), S. 131-139 
    Details
    ISSN: 1432-2072
    Keywords: Key words Startle ; Prepulse inhibition ; Inbred strains ; Haloperidol ; Catalepsy ; Schizophrenia ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The acoustic startle response (ASR), prepulse inhibition (PPI) of the ASR and the effects of haloperidol on the ASR and PPI were examined in C57BL/6J (B6) and DBA/2 (D2) inbred mouse strains and their F1 and F2 progeny. The startle stimulus was a 60-ms, 110-dB, 10-kHz tone; the prepulse stimuli were 20-ms white noise bursts at 56, 68 and 80 dB against a 50-dB background presented 100-ms before the startle pulse. The B6 strain showed modest PPI (25–40%); in contrast, the D2 strain showed on average no PPI and numerous individuals showed prepulse augmentation (PPA). The F2 progeny showed an intermediate PPI; however, the extreme values ranged from 200% PPA to essentially 100% PPI. Haloperidol in dose-dependent fashion, increased PPI in both the B6 and D2 strains; the threshold dose was in the range of 0.1–0.2 mg/kg. Raclopride (0.3 mg/kg), clozapine (2 mg/kg) and risperidone (0.4 mg/kg) also increased PPI in both strains. The effects of haloperidol (0.4 mg/kg) on PPI in 140 F2 progeny were examined. For all prepulse intensities, there were highly significant (r 〉 0.80) and negative correlations between baseline PPI and the haloperidol-induced change in PPI. Thus, those animals that showed the greatest PPA showed the greatest haloperidol-induced increase in PPI. There was, however, significant variance in the haloperidol response; plots of the regression residuals showed the most and least responsive animals differed by almost 100% in effect on PPI. The F2 progeny were subsequently phenotyped for haloperidol-induced catalepsy. There was no association between the variation in effects on catalepsy and PPI. However, it was observed that those individuals with the poorest baseline PPI were catalepsy non-responsive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050434
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  • 29
    Electronic Resource
    Electronic Resource
    Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies (1997)
    Springer
    Psychopharmacology 132 (1997), S. 107-124 
    Details
    ISSN: 1432-2072
    Keywords: Key words Mouse ; Inbred strains ; Behavior ; Genetics ; Locomotion ; Open field activity ; Learning ; Memory ; Aggression ; Parental behaviors ; Acoustic startle ; Prepulse inhibition ; Alcohol ; Nicotine ; Cocaine ; Opiates ; Haloperidol ; Diazepam ; Breeding ; Embryonic stem cell lines ; Transgenic ; Knockouts ; Null mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050327
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  • 30
    Electronic Resource
    Electronic Resource
    The effects of cocaine on operant responding for food in several strains of mice (1997)
    Springer
    Psychopharmacology 132 (1997), S. 202-208 
    Details
    ISSN: 1432-2072
    Keywords: Key words Cocaine ; Operant behavior ; Genetics ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The availability of numerous genetically homogenous mouse strains permits the analysis of genetic influences on behavior and also behavioral sensitivity (responsivity) to drugs of abuse. The current study was conducted to characterize discriminated operant responding for food in four inbred strains (Balb/cByJ, DBA/2J, C57BL/6J, SJL/J), an F1 Hybrid (C57BL/6×SJL), and one outbred strain (CD1) of mouse. The effect of cocaine on this operant behavior was also examined. Initially, all animals were trained to nosepoke for food on a continuous reinforcement schedule. The minimum response requirement for reinforcement was increased every 5 days until the animals were responding on an FR-15 schedule of reinforcement. All strains increased operant responding as the schedule of reinforcement was raised. However, significant differences in response rate and discrimination learning were observed among the various strains of mice. Cocaine administration reduced operant responding for food in Balb/cByJ, C57BL/6J, C57BL/6×SJL/J and CD1 mice at a dose of 15.0 mg/kg, whereas higher doses were required in DBA/2J mice (30.0 mg/kg) and SJL/J mice (56.0 mg/kg). These results suggest that operant performance and the effect of cocaine on this behavior is differentially influenced by genetic make-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050337
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  • 31
    Electronic Resource
    Electronic Resource
    Homoclinic chaos in a model of natural selection (1997)
    Springer
    Journal of mathematical biology 35 (1997), S. 294-320 
    Details
    ISSN: 1432-1416
    Keywords: Key words: Natural selection ; Homoclinic chaos ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract.  We modify a simple mathematical model for natural selection originally formulated by Robert M. May in 1983 by permitting one homozygote to have a larger selective advantage when rare than the other, and show that the new model exhibits dynamical chaos. We determine an open region of parameter space associated with homoclinic points, and prove that there are infinite sequences of period-doubling bifurcations along selected paths through parameter space. We also discuss the possibility of chaos arising from imbalance in the homozygote fitnesses in more realistic biological situations, beyond the constraints of the model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002850050053
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  • 32
    Electronic Resource
    Electronic Resource
    Expression of a unique plastid-localized heat-shock protein is genetically linked to acquired thermotolerance in wheat (1997)
    Springer
    Theoretical and applied genetics 95 (1997), S. 834-841 
    Details
    ISSN: 1432-2242
    Keywords: Key words Stress proteins ; Heat tolerance ; Chloroplast ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  We have used a combination of molecular and classical genetic approaches to delineate the relationship between a specific HSP member and cell viability under heat stress. Using recombinant inbred lines (RILs) of wheat, derived from a cross of the thermotolerant cultivar ‘Mustang’ and the thermosusceptible cultivar ‘Sturdy,’ we have identified a unique HSP and a differentially expressed cDNA sequence, both related to the plastid-localized HSP26 gene family, that are closely associated with acquired thermotolerance in wheat. An isoform of HSP26 was synthesized under heat stress in all examined thermotolerant RILs and ‘Mustang’, and was absent in all examined thermosusceptible RILs and ‘Sturdy.’ Using a modified differential-display method, we have also identified a gene-specific cDNA sequence that is similar to other known members of the wheat HSP26 gene family and is selectively expressed in ‘Mustang’ and most of the examined thermotolerant RILs, but not expressed in ‘Sturdy’ and all the thermosusceptible RILs. These results suggest a genetic linkage between the acquired thermotolerance trait and the differential expression of a unique member of the HSP26 gene family.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050633
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  • 33
    Electronic Resource
    Electronic Resource
    Extreme resistance to potato virus V in clones of Solanum tuberosum that are also resistant to potato viruses Y and A: evidence for a locus conferring broad-spectrum potyvirus resistance (1997)
    Springer
    Theoretical and applied genetics 95 (1997), S. 1258-1262 
    Details
    ISSN: 1432-2242
    Keywords: Key words Extreme virus resistance ; Potyviruses ; Genetics ; Genes Rysto and Ra ; Broad-spectrum resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Extreme resistance to the potato V potyvirus (PVV) was found in four potato cultivars that contain Ry genes from Solanum stoloniferum. When plants of these cultivars, were inoculated by grafting in shoot tips from PVV-infected tomato plants, necrotic symptoms developed in some cultivars, although a full hypersensitive reaction was not elicited, while other cultivars were symptomless. PVV replication was not detected in any of the inoculated plants by ELISA, an infectivity assay of leaf extracts by manual inoculation to Nicotiana benthamiana indicator plants, or by ‘return grafting’ of shoot tips taken from newly developed shoots of the potato plants to virus-free indicator plants of tomato. These methods readily detected PVV infection in inoculated plants of cv ‘Flourball’, which does not contain an Ry gene and is susceptible, and in cvs ‘Maris Piper’ and ‘Dr Macintosh’, which contain gene Nv conditioning a hypersensitive reaction to inoculation. One of the Ry-containing cultivars, ‘Barbara’, has been previously shown to contain two genes that control extreme resistance, defined as no viral replication in intact plants, to the potyviruses potato viruses Y and A (PVY and PVA). These genes are: Ry sto , which conditions resistance to PVY and PVA, and gene Ra, which conditions resistance to PVA only. It was found that in genotypes from a progeny of the cross ‘Barbara’ (Ry sto /Ra)בFlourball’ (ry/ra), extreme resistance to PVV segregated with gene Ry sto . It is proposed that either gene Ry sto conditions broad-spectrum extreme resistance to the distinct potyviruses PVY, PVA, and PVV or that Ry sto represents a family of genetically closely linked genes each controlling resistance to a specific virus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050690
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    Resistance to Phytophthora fragariae var. fragariae in strawberry: the Rpf2 gene (1997)
    Springer
    Theoretical and applied genetics 94 (1997), S. 1092-1096 
    Details
    ISSN: 1432-2242
    Keywords: Key words Fragaria×ananassa ; Genetics ; Inheritance ; Red core ; Red stele
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract   Phytophthora fragariae var. fragariae is the causal agent of red stele (red core) root rot in strawberry (Fragaria spp.). The inheritance of resistance to one isolate of this fungus was studied in 12 segregating populations of F.×ananassa derived from crosses between four resistant cultivars (‘Climax’, ‘Redgauntlet’, ‘Siletz’, and ‘Sparkle’) and three susceptible cultivars (‘Blakemore’, ‘Glasa’, and ‘Senga’ Sengana’). The analysis clearly supports the hypothesis of a single segregating dominant resistance gene. It is proposed that this gene be designated Rpf2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050520
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    Genetic aspects of childhood behavioral disorders (1997)
    Springer
    Child psychiatry & human development 27 (1997), S. 139-150 
    Details
    ISSN: 1573-3327
    Keywords: ADHD ; Tourette Syndrome ; Genetics ; Gene Selection ; Conduct Disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The evidence is reviewed to support the concept that many disruptive, childhood and adolescent behavioral disorders including ADHD, Tourette syndrome, learning disabilities, substance abuse, oppositional defiant disorder and conduct disorder, are part of a spectrum of inter-related behaviors that have a strong genetic component, are polygenically inherited, share a number of genes in common that affect dopamine, serotonin and other neurotransmitters, and are transmitted from both parents. Some of the implications of this hypothesis in relation to diagnosis and treatment are reviewed, including the possibility that the genes involved may be increasing in frequency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02353694
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    Computerized EEG topography of normal preadolescent twins—Correlating similarity of background activity with genetic relatedness (1997)
    Springer
    Brain topography 9 (1997), S. 303-311 
    Details
    ISSN: 1573-6792
    Keywords: EEG normality ; Brain topography ; Twins ; Genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of genetic relatedness on the similarity degree of topographical EEG parameters was studied in a sample of 26 sets of monozygotic (MZ) and 46 sets of dizygotic (DZ) twins. All 144 subjects were healthy, primary school children, aged 7–15 years, 69 boys and 75 girls. Correlation coefficients were calculated for 50 quantitative EEG parameters of paired values obtained at each of 16 active electrode sites, in four groups of paired tracings: 1. MZ twins, 2. DZ twins, 3. The autocorrelated (A) group formed by correlating the spectral parameters from the same subjects in two different analyzed sequences, 4. The random (R) control group of 1200 unrelated pairs formed from DZ twin pairs. Sets of MZ twins and A group showed the highest degrees of similarity of spectral parameters over all brain areas except for significant differences only for some background features over posterior regions. In contrast, highly significant differences in topographic parameters were evident in comparison of MZ sets with DZ sets, particularly when MZ sets were compared with DZ subsets of opposite sex. Both number and degree of significant differences increased progressively in comparisons with groups 3 vs 2,1 vs 4, and 3 vs 4. The data gave strong evidence for a complex polygenic determination of normal human EEG topography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01464485
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    Generalized linear elasticity in exterior domains. I: Radiation problems (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1469-1500 
    Details
    ISSN: 0170-4214
    Keywords: radiating solutions ; exterior boundary value problem in elasticity ; variable coefficients ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We use Hodge-Helmholtz decompositions of weighted Sobolev spaces to solve time-harmonic exterior-boundary value problems for perturbations of the (aδd+bdδ)-system (δ: the co-differential, a, b〉0). We prove, that a Fredholm alternative holds true, the eigensolutions decay polynomially at infinity, and that the positive eigenvalues do not accumulate. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    The 2-D Neumann problem in an exterior domain bounded by closed and open curves (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1551-1562 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The Neumann problem for the Laplace equation in an exterior connected plane region bounded by closed and open curves is studied. The existence of classical solution is proved by potential theory. The problem is reduced to the Fredholm equation of the second kind, which is uniquely solvable. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Numerical methods for scattering problems by curved gratings at high frequencies (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1531-1549 
    Details
    ISSN: 0170-4214
    Keywords: gratings ; Helmholtz equation ; high frequencies ; geometric theory of diffraction ; transition regions ; finite element method ; error estimates ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: A new numerical method is derived for the calculation of high-frequency asymptotic expansions of the scalar wave scattered by curved periodic structures. Optimal error estimates for this method are established. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
    Additional Material: 5 Ill.
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    Classification of smooth solutions to 2×2 hyperbolic systems with boundary damping (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1563-1598 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We give a complete classification for breakdown in finite time or global existence of continuously differentiable solutions to hyperbolic systems of two first-order partial differential equations posed on a real bounded interval, with boundary damping and initial data of small magnitude. Structural bounds for the derivatives of the initial data which govern the behavior of the solution are brought to light. We isolate two classes of boundary damping: the strong damping forbids the solution to blow up after a time that we exhibit while the weak damping permits a late breakdown. The results are applied to nonlinear elasticity. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
    Additional Material: 4 Ill.
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    Singular Stress Behavior in a Bonded Hereditarily-Elastic Aging Wedge. Part II: General Heredity (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 31-45 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: No Abstract
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    On Representation Formulas and Radiation Conditions (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 133-150 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Solutions of linear elliptic partial differential equations in unbounded domains can be represented by boundary potentials if they satisfy certain conditions at infinity. These radiation conditions depend on the fundamental solution chosen for the integral representation. We prove some basic results about radiation conditions in a rather general framework.Fundamental solutions G are considered that are defined only on the complement of a compact set. It turns out, however, and we present examples for this, that the more interesting results only hold if G is defined on all of ∝n or if it is a Green function for an exterior boundary value problem. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    Attractors and Approximate Inertial Manifolds for the Generalized Benjamin-Bona-Mahony Equation (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 189-203 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In the present paper, we deal with the long time behaviour of solutions for the generalized Benjamin-Bona-Mahony equation. By a priori estimates methods, we show this equation possesses a global attractor in Hk for every integer k≥2, which has finite Hausdorff and fractal dimensions. We also construct approximate inertial manifolds such that every solution enters their thin neighbourhood in a finite time. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    Factorization of a class of matrices generated by Sommerfeld diffraction problems with oblique derivatives (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1185-1198 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: An explicit factorization of the Fourier symbol matrix functions generated by Sommerfeld diffraction problems with oblique derivatives is obtained. For this purpose a new prefactorization procedure is developed which makes use of factorization through weighted L2 spaces. These results yield a representation of a generalized inverse of the corresponding matrix Wiener-Hopf operator and the asymptotic behaviour of the solution at the edge of the screen. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    On quasi-linear Schrödinger-Poisson systems (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1223-1238 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We study a high-field version of the periodic Schrödinger-Poisson system, for which the Poisson equation includes nonlinear terms corresponding to a field-dependent dielectric constant. Using a Galerkin scheme, we prove global existence and uniqueness, and present the matrix equations for the numerical evaluation of the potential. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    A generalized temperature-dependent, non-Newtonian Hele-Shaw flow in injection and compression moulding (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1199-1222 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: A generalized Hele-Shaw flow is derived and analysed in injection and compression moulding which contains non-isothermal and non-Newtonian rheological behaviour of the molten polymers as well as non-symmetric effects. The corresponding fixed domain formulations for the flow are investigated from a mathematical point of view. Different approaches for the determination of the temperature and some viscosity models are discussed. Together with an outline of the proposed solution algorithm special finite element techniques are described for the numerical treatment of this complex non-linear moving boundary problem. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
    Additional Material: 3 Ill.
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    On the Validity of the degenerate Ginzburg - Landau equation (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1239-1256 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The Ginzburg-Landau equation which describes nonlinear modulation of the amplitude of the basic pattern does not give a good approximation when the Landau constant (which describes the influence of the nonlinearity) is small. In this paper a derivation of the so-called degenerate (or generalized) Ginzburg-Landau (dGL)-equation is given. It turns out that one can understand the dGL-equation as an example of a normal form of a co-dimension two bifurcation for parabolic PDEs. The main body of the paper is devoted to the proof of the validity of the dGL as an equation whose solution approximate the solution of the original problem. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    The Dirichlet problem for Stokes equation in a domain exterior to an open surface (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1257-1269 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The paper deals with the Dirichlet problem for the Stokes linear equation in a domain exterior to an open surface. With the help of the theory of boundary integral (pseudo-differential) equations uniqueness and existence theorems are proved in the Bessel-potential and Besov spaces and Cα-smoothness (with α〈1/2) of solution is established in the neighbourhood of the boundary of the open surface. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Long-time behaviour of ferromagnetic spin chain equation: global attractor and its dimension (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1271-1281 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper the authors consider the initial boundary value problem of the ferromagnetic spin chain equation and prove the existence of the global attractor and finiteness of the Hausdorff and the fractal dimensions of the attractor. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    On stationary Schrödinger-Poisson equations modelling an electron gas with reduced dimension (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1283-1312 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We regard the Schrödinger-Poisson system arising from the modelling of an electron gas with reduced dimension in a bounded up to three-dimensional domain and establish the method of steepest descent. The electrostatic potentials of the iteration scheme will converge uniformly on the spatial domain. To get this result we investigate the Schrödinger operator, the Fermi level and the quantum mechanical electron density operator for square integrable electrostatic potentials. On bounded sets of potentials the Fermi level is continuous and bounded, and the electron density operator is monotone and Lipschitz continuous. As a tool we develop a Riesz-Dunford functional calculus for semibounded self-adjoint operators using paths of integration which enclose a real half-axis. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Existence results for non-autonomous multiple-fragmentation models (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1313-1323 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We investigate an initial-value problem modelling fragmentation processes where particles split into two or more pieces at a rate, γ, that not only depends on the sizes of the particles involved but also on time. The existence of non-negative, mass-conserving solutions is established by considering a truncated version of an associated non-autonomous abstract Cauchy problem. The latter has solutions of the form u(t)=Un(t,t0)f, t≥t0, where f is the known data at some fixed time t0≥0 and {Un(t,s)}t0≤s≤t≤T is a uniformly continuous evolution system. A limit evolution system {U(t,s)}t0≤s≤t≤T is shown to exist. Depending on the form of the known data f at time t0, the scalar-valued function u, obtained from the limit evolution system via u(x, t)=[U(t, t0)f](x) for a.e. x〉0, t≥t0, is a solution of either the original initial-value problem or an integral version of this problem. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Global solutions of the Laplace equation with a nonlinear dynamical boundary condition (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1325-1333 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We study the boundedness and a priori bounds of global solutions of the problem Δu=0 in Ω×(0, T), (∂u/∂t) + (∂u/∂ν) = h(u) on ∂Ω×(0, T), where Ω is a bounded domain in ∝N, ν is the outer normal on ∂Ω and h is a superlinear function. As an application of our results we show the existence of sign-changing stationary solutions. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Spatial bounds and growth estimates for the heat equation with three relaxation times (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1335-1344 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this note we investigate spatial bounds for the heat conduction equation with three relaxation times. We use energy methods similar to those considered in the study of the backward parabolic heat equation. Finally, we show that for any positive choice of the coefficients we may take initial data for which the solution is unstable when we suppose that the body is bounded. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Continuous sedimentation of multi-component particles (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1345-1364 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Continuous sedimentation of solid particles in a liquid takes place in a clarifier-thickener unit, which has one feed inlet and two outlets. The process is vital in a waste water treatment plant, where the particles consist of several biological components. The concentrations of these are modelled by a one-dimensional system of conservation laws with source term. It is shown how a unique solution can be obtained, and how analytical solutions are used to form a conservative numerical algorithm. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Subsonic solutions of hydrodynamic model for semiconductors (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1389-1410 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This paper is concerned with the existence and uniqueness of the steady-state solution of hydrodynamic model for semiconductor devices. Boundary conditions are prescribed by vorticity on inflow boundary as well as by electron density, temperature, and normal component of electron velocity on whole boundary. If the ambient temperature is large, and if both vorticity on inflow boundary and the variation of density on boundary are small, a unique subsonic solution exists. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Asymptotic solution of a non-linear wave motion in an electron plasma (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1379-1388 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The theory of high-frequency waves has been used to calculate first and second-order asymptotic solutions for the propagation of non-linear waves in a cylindrical symmetric flow of an electron plasma. The behaviour of acceleration waves and weak shock waves has been analysed through these solutions and Whitham's rule for a weak shock wave on any wavelet has been confirmed through the first-order solution. The appearance of a weak shock wave on any wavelet has been determined and its strength, the location, and the speed of propagation have been found from the asymptotic solution presented in this paper. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    The amount of non-uniqueness for factored equations with Euler-Poisson-Darboux factors (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1449-1457 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Of concern are factored Euler-Poisson-Darboux equations of the type∏Nj=1(d2/dt2+(ρ/t)d/dt+Aj)u(t)=0,where, for example, Aj=-cjΔ, Δ being the Dirichlet Laplacian acting on L2(Ω), Ω⊂∝n, and 0〈c1〈…〈cN. More generally -Aj can be the square of the generator of a (C0) group on a Banach space. When the constant ρ is negative, the initial value problem for the factored EPD equation is ill-posed. Nevertheless, we determine how many initial conditions are necessary to guarantee uniqueness of a solution. This number jumps up as ρ crosses a negative integer from right to left. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    On Global Existence, Asymptotic Stability and Blowing Up of Solutions for Some Degenerate Non-linear Wave Equations of Kirchhoff Type with a Strong Dissipation (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 151-177 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We study on the initial-boundary value problem for some degenerate non-linear wave equations of Kirchhoff type with a strong dissipation:\documentclass{minimal} \begin{document} \[ u_{tt}=\left\| \nabla u\right\| ^{2\gamma }\Delta u-\Delta u_t=\left| u\right| ^\alpha u,\quad u(0)=u_0,\;u_t(0)=u_1,\;u|_{\partial \Omega }=0. \] \end{document}When the initial energy $E(u_0,u_1)\equiv \left\| u_1\right\| ⁁2+\frac 1{\gamma +1}\left\| \nabla u_0\right\| ⁁{2(\gamma +1)}-\frac 2{\alpha+2}\left\| u_0\right\| _{\alpha +2}⁁{\alpha +2}$ associated with the equations is non-negative and small, a unique (weak) solution exists globally in time and has some decay properties. When the initial energy E(u0,u1) is negative, the solution blows up at some finite time. In the proof we use the ‘modified potential well’ and ‘Concavity’ methods. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    Existence of a Classical Solution for a Multidimensional Filtration Problem (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 179-187 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We prove existence, in a small time interval, of a classical solution having a regular free boundary, (i.e. the level set {u=0}) of a multidimensional filtration problem. The key point to get the regularity of the level set {u=0} is the proof of an a priori estimate for the L∞-norm of ut. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    On Stationary Solutions of the Relativistic Vlasov-Maxwell System (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 667-677 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We study stationary solutions of the relativistic Vlasov-Maxwell system of plasma physics which have a special form introduced (in the classical setting) by Rudykh, Sidorov and Sinitsy and establish their existence under suitable assumptions on the ansatz functions. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd. Math. Meth. Appl. Sci., Vol. 20, 667-677 (1997).
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    Convergence of Solutions of the Landau Equations in the Collisionless Limit (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 679-688 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This paper addresses the question: when the frequency of collisions vanishes, will the solutions of the Landau system converge to the solutions of the Vlasov system? We give a positive answer to the question for solutions satisfying certain regularity conditions. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd. Math. Meth. Appl. Sci., Vol. 20, 679-688 (1997).
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    Analysis of a Non-hyperbolic System Modeling Two-phase Flows Part 1: The Effects of Diffusion and Relaxation (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 783-803 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The paper considers the non-linear stability of a non-hyperbolic system of conservation laws with both relaxation and diffusion, which is commonly used for the modeling of two-phase fluid flows. Global existence in time is proved for initial data with a sufficiently small H1 norm. This result heavily depends on the nice structure of the relaxation system, derived from the initial system by setting the relaxation variables to zero. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    The dam problem for non-linear Darcy's laws and non-linear leaky boundary conditions (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1045-1068 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The goal of this paper is to establish that even for strongly non-linear Darcy's laws and strongly non-linear leaky boundary conditions on the bottom of the reservoirs the fluid flow through a porous dam is a well-posed problem for which existence of a solution can be established. In a simple case we provide also the exact solution to the problem. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Convex domains with stationary hot spots (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1163-1169 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Consider the problem of heat flow in a convex domain in ∝n with Dirichlet boundary condition and constant initial temperature. We show that the solution has a fixed hot spot if the domain is invariant under the action of an essential symmetry group. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Exponential decay for the one-dimensional wave equation with internal pointwise damping (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1171-1183 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The paper considers a particular type of closed-loop for the wave equation in one space dimension with damping acting at an arbitrary internal point, for which the uniform stabilization with exponential decay rate is shown. Applications to chains of coupled strings are also discussed. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    A non-linear parabolic control problem with non-homogeneous boundary condition - convergence of Galerkin approximation (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1365-1377 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The paper is concerned with optimal control problem for a non-linear parabolic equation with non-homogenous boundary condition and quadratic cost. The control is acting in a nonlinear equation. We derive some results on the existence of optimal controls. Then we treat optimal control problem by Galerkin method and we prove the convergence of optimal values for approximated control problems to the one for the original problem. Finally, we apply the results to give a simple example. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    On a fractional partial differential equation with dominating linear part (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1427-1448 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: It is proved that there is a (weak) solution of the equationut=a*uxx+b*g(ux)x+f,on ∝+ (where * denotes convolution over (-∞, t)) such that ux is locally bounded. Emphasis is put on having the assumptions on the initial conditions as weak as possible. The kernels a and b are completely monotone and if a(t)=t-α, b(t)=t-β, and g(ξ)∼sign(ξ)∣ξ∣γ for large ξ, then the main assumption is that α〉(2γ+2)/(3γ+1)β+(2γ-2)/(3γ+1). © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Numerical solution of viscoplastic constitutive equations with internal state variables Part I: algorithms and implementation (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1411-1425 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This article treats the initial-boundary-value problem of viscoplasticity using unified constitutive models without a yield surface. Semi-discretization with the finite element method (FEM) leads to a system of differential-algebraic equations (DAE) with strongly non-linear evolution equations for the internal state variables. A special family of partitioned Runge-Kutta methods is introduced which allows an efficient time integration of the semidiscrete system. Coefficients for methods of order one, two, and three are given. Finally, numerical results for some two- and three-dimensional examples using the model of Hart are presented. In a second part we will give the theoretical background and state a proof of convergence for the algorithm presented in this paper. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Asymptotic spatial homogeneity of solutions to conservation laws with memory in several space dimensions (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1459-1468 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We prove that any solution of the problem(u+K*u)t+∑ai(u)uxi=0 on (0,∞)×∝Nwith spatially periodic initial data converges to a constant provided some non-degeneracy conditions on the kernel K and the non-linear functions ai,i=1,…,N are imposed. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Generalized linear elasticity in exterior domains. II: low-frequency asymptotics (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1501-1530 
    Details
    ISSN: 0170-4214
    Keywords: radiating solutions ; exterior boundary value problems in elasticity ; asymptotic expansions ; low-frequency behaviour ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We continue the study of the operators of generalized linear elasticity and investigate the behaviour of the solutions as the frequency tends to zero. We identify degenerate operators in terms of special solutions to the static problem which must be added to the usual Neumann series in order to describe the low frequency behaviour adequately. As a byproduct we construct solutions to the homogeneous static operator (‘spherical elastics’) which generalize the spherical harmonics and give rise to a ‘spherical elastics expansion’. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Half-space Fourier transform in application to non-linear hyperbolic initial-boundary-value problem: low regularity solutions (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1599-1616 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The Dirichlet initial-boundary-value problem in the half-space ∝t×∝3+ for a non-linear hyperbolic system is studied. About the nonlinearity the null condition structure is imposed. Under the smallness conditions on the initial data the existence of low regularity solutions, on a given interval of time, is proved. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Clifford analysis on spheres and hyperbolae (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 1617-1624 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We develop aspects of Clifford analysis over the sphere and hyperbolae. We focus primarily on the hyperbola lying in the Minkowski type space ∝n,1. We show that in order to give a proper extension of basic results on Clifford analysis in Euclidean space to this context one needs to consider both hyperbolae lying in ∝n,1. We also introduce Bergman spaces of Lp left monogenic sections in this context and consider the decomposition of square integrable sections over suitable bundles constructed over subdomains of spheres and hyperbolae. The results presented here cover the necessary background to enable one to set up and solve boundary value problems for field-type equations over hyperbolae. In particular, one can study analogues of the Dirichlet problem for analogues of the Laplacian over hyperbolae and spheres. © 1997 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Dissipative Feedback Synthesis for a Singularly Perturbed Model of a Piston Driven Flow of a Non-Newtonian Fluid (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 79-94 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The limiting behaviour of solutions of a system of singularly perturbed equations is studied. The goal is to construct a dissipative feedback control synthesis that stabilizes the prescribed output functional along trajectories of solutions. The results are applied to a singularly perturbed Johnson-Sagelman-Oldroyd model of shearing motions of a piston driven flow of a non-Newtonian fluid. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    Boundary Integral Equation Method in the Steady State Oscillation Problems for Anisotropic Bodies (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 95-119 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The three-dimensional steady state oscillation problems of the elasticity theory for homogeneous anisotropic bodies are studied. By means of the limiting absortion principle the fundamental matrices maximally decaying at infinity are constructed and the generalized Sommerfeld-Kupradze type radiation conditions are formulated. Special functional spaces are introduced in which the basic and mixed exterior boundary value problems of the steady state oscillation theory have unique solutions for arbitrary values of the oscillation parameter. Existence theorems are proved by reduction of the original boundary value problems to equivalent boundary integral (pseudodifferential) equations. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    Error Estimates for the Boundary Element Approximation of a Contact Problem in Elasticity (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 205-217 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The two-dimensional frictionless contact problem of linear isotropic elasticity in the half-space is treated as a boundary variational inequality involving the Poincare-Steklov operator and discretized by linear boundary elements. Quadratic growth of the energy near the solution is shown under weak regularity assumptions if the central axis of external forces intersects the boundary of the domain in a Lebesgue null set. Estimating the numerical range of the discrete Poincare-Steklov operator and properly modifying it, enables the application of an error estimate for semi-coercive variational inequalities. Optimal order of convergence is obtained in the underlying Sobolev space H1/2(∂Ω)2. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    Korn's Inequalities for Junctions of Spatial Bodies and Thin Rods (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 219-243 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The dependence on the small parameter ε of constants in Korn's inequalities is investigated for domains which are obtained by joining thin rods to an elastic spatial body. The external ends of the rods are clamped. The asymptotic accuracy of the derived inequalities is achieved by certain distribution of weight multipliers and powers of ε in L2-norms of displacements and their derivatives while the introduced weights differ for longitudinal and transversal components of displacement fields in the rods. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    Asymptotic Behaviour of Solutions to some Pseudoparabolic Equations (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 271-289 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The aim of this paper is to investigate the behaviour as t→∞ of solutions to the Cauchy problem ut-Δut-νΔu-(b, ∇u)=∇⋅F(u), u(x, 0)=u0(x), where ν〉0 is a fixed constant, t≥0, x∊∝n. First, we prove that if u is the solution to the linearized equation, i.e. with ∇⋅F(u)≡0, then u decays like a solution for the analogous problem to the heat equation. Moreover, the long-time behaviour of u is described by the heat kernel. Next, analogous results are established for the non-linear equation with some assumptions imposed on F, p, and the initial condition u0. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    Finite Element Methods for the Stokes System in Three-Dimensional Exterior Domains (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 245-269 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The article treats the question of how to numerically solve the Dirichlet problem for the Stokes system in the exterior of a three-dimensional bounded Lipschitz domain. In a first step, the solution of this problem is approximated by functions solving the Stokes system in a truncated domain and satisfying a suitable artificial boundary condition on the outer boundary of this truncated domain. In a second step, this new problem is approximately solved in finite element spaces related to a graded mesh as introduced by Goldstein [Math. Comp., 36, 387-404 (1981)]. The difference between this finite element approximation and the exact solution of the exterior Stokes problem is estimated in the norm of suitable unweighted L2-Sobolev spaces. These estimates are analogous to corresponding results which are known for the Poisson equation. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    Inverse Problems for Identification of Memory Kernels in Viscoelasticity (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 291-314 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Inverse problems for identification of the memory kernel in the linear constitutive stress-strain relation of Boltzmann type are reduced to a non-linear Volterra integral equation using Fourier's method for solving the direct problem. To this equation the contraction principle in weighted norms is applied. In this way global existence of a solution to the inverse problem is proved and stability estimates for it are derived. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Control of Matter Waves in Adjacent Potential Wells (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 369-381 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider exact controllability of a system of two Schrödinger equations. These represent matter waves in adjacent potential wells with different potentials, one zero, the other a positive constant V0. The problem is formulated as a simultaneous boundary controllability problem, with Dirichlet control. Estimates for the controls, including an observability inequality, are proved using multiplier techniques. Then the Hilbert uniqueness method is used to obtain the exact controllability result. If V0 is sufficiently small, there exists a time T^(V0) such that the system is exactly controllable in times T〉T^(V0). © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    On ‘Power-logarithmic’ Solutions to the Dirichlet Problem for the Stokes System in a Dihedral Angle (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 315-346 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The Dirichlet problem for the Stokes system in a dihedral angle is considered. An explicit description of special solutions to the homogeneous problem which have the form\documentclass{minimal} \begin{document} \begin{eqnarray*} U(x) &=&\left| x\right| ^\lambda \sum_{0\leq k\leq \kappa }\frac{(\log \left| x\right|)^{\kappa -k}}{(\kappa -k)!}u^{(k)}(x/\left| x\right|), \\ P(x) &=&\left| x\right| ^{\lambda -1}\sum_{0\leq k\leq \kappa }\frac{(\log \left| x\right|)^{\kappa -k}}{(\kappa -k)!}p^{(k)}(x/\left| x\right|) \end{eqnarray*} \end{document}is given. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    On the Heat Convection Equations with Dissipation Term in Regions with Moving Boundaries (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 347-368 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider an initial value problem for a system of equations describing the motion and the heat convection in a viscous and incompressible fluid which occupies a smooth region Ωt⊂∝3 depending on time.In the equation for the distribution of temperature in the fluid we take into account not only the convective term but also the term responsible for the dissipation of energy.We prove local in time existence and uniqueness of solutions of the considered problem, and global in time existence for sufficiently small data. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    The Solvability of Boundary Equations in Mixed Problems for Non-stationary Maxwell's System (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 425-448 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The work deals with boundary equations appearing if non-stationary problems for Maxwell system are solved with the help of surface-retarded potentials. The solvability of these equations is proved in some functional spaces of Sobolev type. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    A New Algorithm in Electromagnetic Inverse Scattering Theory with an Application to Medical Imaging (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 385-401 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider the electromagnetic inverse scattering problem of determining the index of refraction of an isotropic inhomogeneous medium from a knowledge of the total electric near field data. We consider both the case of scattering by an infinite inhomogeneous cylinder and a bounded inhomogeneous region in space. We conclude by giving an application of our method to the problem of imaging leukemia in the upper leg by means of microwaves. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Parabolic Problems and Boundary Integral Equations (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 449-459 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Here we consider initial boundary value problems for parabolic equations in non-bounded (with respect to time) domains by using the single-layer potential. We discuss the solvability in anisotropic Hölder spaces of the boundary integral equations, to which original parabolic problems are reduced. We construct the special operators (regularizers) for these integral equations which transform them to equivalent integral Volterra equations of the second kind with weakly singular kernels. As a corollary we obtain the theorem about the classical solvability in anisotropic Hölder spaces for initial boundary value parabolic problems. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Adaptive Coupling and Fast Solution of FEM-BEM Equations for Parabolic-Elliptic Interface Problems (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 403-423 
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    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper we prove an a posteriori error estimate for the symmetric coupling of finite elements and boundary elements applied to linear parabolic-elliptic interface problems. The discontinuous Galerkin method is used for the discretization in time. We present an adaptive algorithm for choosing the mesh size in space and time and we analyse the Hybrid Modified Conjugate Residual (HMCR) method as a solution method for the linear systems which arise. Computational results show that the number of HMCR-iterations grows slowly with the problem size. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
    Additional Material: 4 Ill.
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  • 87
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    Editorial: G. C. Hsiao on his 60th birthday (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 383-384 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: No Abstract
    Type of Medium: Electronic Resource
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  • 88
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    Difference Methods for Quasilinear 2D-diffusion Problems in Toroidal Configurations (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 477-493 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Implicit one-step difference methods for quasilinear parabolic initial boundary value problems in two space variables and in polar coordinates are considered. Problems of this kind are suitable for the description of diffusion processes in plasma physics. Therefore, because of its special physical interest the dependence of the coefficients both on the solution and on its space derivatives (the fluxes) is included. The first part of this paper deals with proving convergence of the discrete approximations for vanishing step sizes. For this purpose, bounds for the inverse difference operators have to be derived previously. The nonlinear systems arising from the discretizations have exactly one solution for all step sizes being sufficiently small. In the second part of the article numerical tests are performed. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
    Additional Material: 9 Ill.
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  • 89
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    On the Existence of Trapped Modes in Channels of Arbitrary Cross-section (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 521-545 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This article establishes the existence of trapped-mode solutions of a linearized water-wave problem. The fluid occupies a symmetric horizontal channel that is uniform everywhere apart from a confined region which either contains a thin vertical plate spanning the depth of the channel or has indentations in the channel walls. A trapped mode corresponds to an eigenvalue of a non-local Neumann-Dirichlet operator for an elliptic boundary-value problem in the fluid domain. The existence of such an eigenvalue is established by generalizing previous results concerning spectral theory for differential operators to this non-local operator. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
    Additional Material: 6 Ill.
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  • 90
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    Classical Global Solutions for Non-linear Klein-Gordon-Schrödinger Equations (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 599-616 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The existence of the classical global solutions for the non-linear Klein-Gordon-Schrödinger equations is proved in H1-subcritical cases for space dimensions n≤5. For higher space dimensions 6≤n≤9, we will give a subsequent paper to deal with. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 91
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    On the Long-time Behaviour of Solutions to a Conservation Law with Memory (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 569-581 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We show that any solution of the scalar conservation law(u+k*u)t+σ(u)x=0starting from spatially periodic initial datum stabilizes to its integral mean as time goes to infinity. No convexity or ‘genuinely non-linear’ like conditions are assumed concerning σ. © 1997 by B. C. Teubner stuttgart-John Wiley & Sons Ltd.
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  • 92
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    Characteristic Symmetric Hyperbolic Systems with Dissipation: Global Existence and Asymptotics (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 583-597 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider the initial-boundary value problem for quasi-linear symmetric hyperbolic systems with dissipation and characteristic boundary of constant multiplicity. We investigate the global existence and decay property of small regular solutions in suitable functions spaces which take into account the loss of regularity in the normal direction to the characteristic boundary. We also show the existence, uniqueness and stability of the time periodic solutions. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 93
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    Uniqueness for Unbounded Classical Solutions of the MHD Equations (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 617-623 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The uniqueness for unbounded classical solutions of the magnetohydrodynamic (MHD) equations in the whole space is investigated. Under suitable growth condition, it is shown that the solution to the initial value problem is unique. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 94
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    Positive Steady-state Solutions of a Non-linear Reaction-Diffusion System (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 625-634 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The steady-state problem of the non-linear reaction-diffusion systemut-uxx=u(av-b),vt-vxx=cuis considered. The existence of positive steady-solutions is established by using a fixed point theorem in ordered Banach space. The uniqueness of ordered positive steady-state solutions and an application to the associated reaction-diffusion system are presented. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 95
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    Sommerfeld Diffraction Problems with Oblique Derivatives (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 635-652 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: A class of diffraction problems for the two-dimensional Helmholtz equation is studied where the boundary conditions on a canonical screen contain oblique derivatives. The problem in weak formulation is reduced to a system of pseudodifferential equations on a half-line. The Fredholm property is characterized in dependence of the parameters, index formulas are given, and, if necessary, a normalization of the problem is implemented. © 1997 by B.G. Teubner Stuttgart-John Wiley & Sons Ltd.
    Additional Material: 4 Ill.
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  • 96
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    Control and Game-Theoretical Treatment of a Cost-Security Model for Disarmament (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 653-666 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper a time-discrete dynamic model for the process of disarmament is investigated. The state variables of the system are costs and security values. We assume that the costs can be controlled, and we aim at reducing the costs to zero and achieving non-negative security values after a finite number of time steps. In the case where the opponents behave cooperatively this leads to the solution of a linear programming problem. If the opponents behave non-cooperatively, then a Nash equilibrium has to be determined under linear constraints. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd. Math. Meth. Appl. Sci., Vol. 20, 653-666 (1997).
    Additional Material: 7 Ill.
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  • 97
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    On Weak Solutions to the Non-stationary van Roosbroeck's System with Discontinuous Permittivities (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 689-706 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper we prove the existence of a weak solution to the non-stationary drift-diffusion equations (van Roosbroeck's system) of semiconductor theory involving discontinuous permittivities. The proof is based on an approximation of these equations by a system with bounded non-linearities, deriving a priori estimates on the approximate solutions and then carrying out the passage to limit. The discussion is completed by some regularity results for the weak solution under consideration. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd. Math. Meth. Appl. Sci., Vol. 20, 689-706 (1997).
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  • 98
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    Study of the Free Streaming Operator in Slab Geometry in Dependence of the Boundary Conditions (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 717-736 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We study the free streaming operator T∧ in a slab domain with boundary conditions described by a linear matrix operator Λ acting between the ‘incoming’ and ‘outgoing’ particle fluxes. Under suitable assumptions on the entries of Λ, it is proved that the resolvent operator of T∧ is positive. It is proved also that T∧ is the generator of a positive strongly continuous semigroup, whose type depends on the norm of the entries of Λ. Some examples are given. In particular the case of Maxwell type boundary conditions is studied and the location of the spectrum of T∧ is improved. © 1997 by B. G. Teubner Stuttgart - John Wiley & Sons Ltd. Math. Meth. Appl. Sci., Vol. 20, 717-736 (1997).
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  • 99
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    Estimating ∇u in terms of div u, curl u, either (ν, u) or ν×u and the topology (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 737-744 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In the present paper we prove Cα-estimates for ∇u using components of boundary values of u, div u, curl u and quantities given by components of boundary values of u as well as boundary values of elements belonging to de Rhams cohomology modules. The vector field u is defined on a bounded set G¯⊂∝3, meanwhile the cohomology group will be defined with regard to ∝3-G. Our inequalities turn out to be a priori estimates concerning well-known boundary value problems for vector fields. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 100
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    A Two-dimensional Stationary Induction Heating Problem (1997)
    Chichester, West Sussex : Wiley-Blackwell
    Mathematical Methods in the Applied Sciences 20 (1997), S. 759-766 
    Details
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider in this paper a system of equations modelling a steady-state induction heating process for ‘two-dimensional geometries’. Existence of a solution is stated in W1,p(Ω) Sobolev spaces and is derived using the Leray-Schauder's fixed point theory. © 1997 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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