ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Racemic or optically active 1-(p-hydroxybenzyl)-1,2,3,4,5,6,-7,8-octahydroisoquinolines (I, Ia or Ib) as well as their O-methyl-ethers (II, IIa or IIb) are dehydrogenated in good yields to 5,6,7,8-tetrahydroisoquinoline derivatives at higher temperature. The conversion of the latter into racemic 1-(p-hydroxybenzyl)-1,2,3,4,5,6,-7,8-octahydroisoquinoline (I) or to the racemic O-methyl ether (II) is achieved either by reduction with sodium in isoamyl alcohol or by catalytic reduction of the quaternary bromobenzylates by way of the tertiary N-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinolines.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19560390525
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