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  • Articles: DFG German National Licenses  (15)
  • 1980-1984  (15)
  • 1
    Electronic Resource
    Electronic Resource
    Photophysics of indole in tetramethylsilane solution. Is there a photoionization threshold? (1982)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 86 (1982), S. 4400-4404 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100219a026
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Photophysics of indole. Comparative study of quenching, solvent, and temperature effects by laser flash photolysis and fluorescence (1981)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 85 (1981), S. 670-677 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j150606a012
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  • 3
    Electronic Resource
    Electronic Resource
    The Stone Age Prehistory of Southern Africa (1983)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Anthropology 12 (1983), S. 25-48 
    Details
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.an.12.100183.000325
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  • 4
    Electronic Resource
    Electronic Resource
    Pressure and temperature effects on human red cell cation transport (1982)
    Springer
    The journal of membrane biology 68 (1982), S. 47-56 
    Details
    ISSN: 1432-1424
    Keywords: hydrostatic pressure ; potassium flux ; erythrocyte membrane ; water of hydration ; anion effect ; thermodynamic analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The effects of hydrostatic pressure and temperature on the three components of K+ uptake in human red cells have been investigated, using ouabain and bumetanide to distinguish between the pump, passive diffusion and cotransport. The pressure sensitivity for passive diffusion has been shown to depend on the counter-ion present. The order of this effect, Cl−〉Br−〉NO 3 − 〉I−, is the same as for the ionic partial modal volumes and the Hofmeister series. We have analyzed our experimental results thermodynamically, and propose a model for the activated transition-state complex of the potassium ion which involves the loss of water molecules from the secondary hydration shell, cosphere II.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01872253
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  • 5
    Electronic Resource
    Electronic Resource
    Interaction of alkyl ammonium derivatives with red cells: Hemolysis and sodium pump inhibition studies (1980)
    Springer
    The journal of membrane biology 55 (1980), S. 123-131 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Members of four homologous series of tetra-alkyl ammonium bromides (R 3N+(CH2) n−1·CH3Br− whereR=H, CH3 or C2H5 andR′N+H3Br− whereR′ represents the isomeric butyl series) have been synthesized and tested as sodium pump inhibitors, measured as ouabain-sensitive K+ influx, and as hemolytic agents on human red cells. Potency for both effects is presented graphically, plotting the logarithm of the concentration for half maximal effect against alkyl chain length. Both hemolysis and pump inhibition studies yielded a biphasic response consisting of two good straight lines, with effectiveness increasing up to C10–12 and then remaining constant up to C20. For hemolysis the alkyl ammonium series was most effective. The calculated free-energy change per methylene group was the same for three series of compounds, but the free-energy contribution from the headgroup was lower for the ammonium series. In contrast, although pump inhibition studies also yielded simple biphasic plots, inhibition occurred at 3- to 50-fold lower concentrations and there were significant differences between the three series, both in the free-energy changes per methylene group and in the headgroup contributions. We have analyzed these results thermodynamically to take account of hydrophobic interactions and the conformation of the alkyl chains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01871154
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  • 6
    Electronic Resource
    Electronic Resource
    Efficacy of a virion envelope herpes simplex virus vaccine against experimental skin infections in hairless mice (1981)
    Springer
    Archives of virology 68 (1981), S. 73-80 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hairless mice were immunized with herpes simplex virus type 1 (HSV-1) envelope antigen (EAG), EAG in association with polyriboinosinic · polyribocytidylic acid-poly-L-lysine complexed with carboxymethylcellulose (PICLC), and inactivated purified HSV-1 (VAG). After 2 weeks the mice were challenged by a percutaneous HSV-1 infection in the orofacial (OF) or lumbosacral (LS) skin area. Following immunization a consistent cell-mediated immune response was observed in all immunized mice, although the humoral immune response was very low, or not detectable. After challenge, a marked secondary humoral and cell-mediated immune response developed in all immunized mice, and the animals were protected against the development of skin lesions and the fatal outcome of infection. However, the establishment of latent infections in the sensory ganglia was not prevented by the immunization procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314437
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  • 7
    Electronic Resource
    Electronic Resource
    The pathogenesis of acute, latent and recurrent herpes simplex virus infections (1982)
    Springer
    Archives of virology 72 (1982), S. 143-168 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01348961
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  • 8
    Electronic Resource
    Electronic Resource
    Increased human red cell cation passive permeability below 12 °C (1980)
    [s.l.] : Nature Publishing Group
    Nature 286 (1980), S. 403-404 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Surprisingly few data are available on the effects of temperature on Na and K transport in human erythrocytes. This may be due in part to the presence of at least three components of Na and K movement in human red cells. These can be resolved as the ouabain-sensitive Na-K pump1'2, the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/286403a0
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  • 9
    Electronic Resource
    Electronic Resource
    Clostridium difficile and cytotoxin in feces of patients with antimicrobial agent-associated pseudomembranous colitis (1982)
    Springer
    Infection 10 (1982), S. 205-207 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 30 Patienten mit Antibiotika-assoziierter Colitis (PMC) wurde der Stuhl aufClostridium difficile und sein Cytotoxin untersucht. Bei drei Patienten waren Coloskopie oder Bariumeinlauf zur Absicherung der Diagnose einer PMC erforderlich, da der Befund der Sigmoidoskopie diagnostisch nicht weiterführte. Bei 27 der 30 Patienten waren Erreger und Cytotoxin nachweisbar; bei zwei der restlichen Patienten wurdeStaphylococcus aureus als Ursache für die PMC ausgeschlossen. 19 Patienten mitC. difficile-induzierter PMC wurden oral mit Vancomycin behandelt, 18 davon sprachen auf die Therapie an; doch trat nach Absetzen von Vancomycin bei sieben Patienten ein Colitis-Rezidiv auf. Diese Rezidive sprachen im allgemeinen auf eine nochmalige Vancomycinbehandlung an. Der Nachweis von Schleimhautplaques oder einer Pseudomembran ist der beste Nachweis für eine Beteiligung vonC. difficile. Der kulturelle Nachweis vonC. difficile in den Faeces und der Cytotoxin-Test sind wegen des Vorkommens von asymptomatischen Trägern in ihrem diagnostischen Wert eingeschränkt.
    Notes: Summary Thirty patients with antimicrobial agent-associated pseudomembranous colitis (PMC) were studied for the presence ofClostridium difficile and its cytotoxin in feces. Either colonoscopy or barium enema radiography was required in three patients for the diagnosis of PMC because of nondiagnostic findings at sigmoidoscopy. Both the organism and cytotoxin were detected in 27 of the 30 patients;Staphylococcus aureus was excluded as the cause of PMC in two of the remaining patients. Eighteen of 19 patients withC. difficile-induced PMC who were treated with oral vancomycin had a salutary response; seven patients, however, had a relapse of colitis following the discontinuation of vancomycin. In general, relapses of colitis responded to retreatment with vancomycin. The implication ofC. difficile as a cause of diarrhea is best achieved by the demonstration of colonic mucosal plaques or of a pseudomembrane. The value of fecal culture forC. difficile and cytotoxin assay is limited by the existence of asymptomatic carriers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01666910
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of denervation on 3H-fucose incorporation by odontoblasts in the mouse incisor (1983)
    Springer
    Cell & tissue research 230 (1983), S. 197-203 
    Details
    ISSN: 1432-0878
    Keywords: Odontoblasts ; Denervation ; Glycoproteins ; Predentin ; 3H-Fucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The present study was designed to determine the effects of denervation on glycoprotein synthesis in the predentinal matrix of the mouse incisor. The inferior alveolar nerve (IAN), superior cervical ganglion (SCG) or both (IAN+SCG) were unilaterally resected in adult mice with the contralateral side remaining intact as a control. Fourteen days after surgery and 4 h prior to killing, 0.2 mCi of 3H-fucose was injected intravenously and mandibles were processed for standard histological and autoradiographic techniques. Silver halide grains were counted over the predentin matrix for 2000 μm per tooth. The results showed that the IAN and SCG resection affected 3H-fucose incorporation into the predentinal matrix; however, the highest absolute mean grain counts occurred after IAN+SCG resection. SCG resection increased the amount of 3H-fucose incorporated into the predentinal matrix by 48%, that of IAN by 24% and that of IAN+SCG by 14% as compared to contralateral controls. These data indicate a regulatory role for the nervous system and a possible interaction of neural components in the control of glycoprotein synthesis by odontoblasts in the mouse incisor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216039
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