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  • 11
    Electronic Resource
    Electronic Resource
    Cytochalasin B inhibits lymphocyte transformation through its effects on glucose transport (1978)
    [s.l.] : Nature Publishing Group
    Nature 272 (1978), S. 359-359 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We titrated the proliferative response of rat thymus lymphocytes to concanavalin A with various concentrations of glucose and cytochalasin B (Fig. 1). In the absence of cytochalasin B, the effect of glucose was biphasic, while little DNA synthesis was observed in the absence of added glucose. Very ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/272359a0
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  • 12
    Electronic Resource
    Electronic Resource
    Triplet state resonance Raman spectroscopy (1978)
    [s.l.] : Nature Publishing Group
    Nature 276 (1978), S. 167-168 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The experimental system has been described previously4. Excited states were produced by electron irradiation with a pulse of high energy electrons. Concentrations and kinetics of the transient species were established by optical absorption spectroscopy, and a pulsed dye laser and an optical ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/276167a0
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  • 13
    Electronic Resource
    Electronic Resource
    Pion interferometry in jet events at the CERN Intersecting Storage Rings (1987)
    Springer
    The European physical journal 36 (1987), S. 517-526 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have observed an enhanced production of pairs and triplets of identical charged particles at small momentum differences in events with two central jets produced inpp collisions at the CERN Intersecting Storage Rings. The size and structure of this ‘Bose-Einstein’ enhancement, shown by the particles within a jet, resembles that observed in minimum-bias events. The correlation function can be well parametrized by the single variableQ — the absolute value of the four-momentum transfer — and is more peaked than a single Gaussian.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01630589
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  • 14
    Electronic Resource
    Electronic Resource
    Myeloperoxidase-deficient polymorphonuclear leucocytes. Longitudinal study during the preremission — and the remission phase in acute myeloid leukaemia (1986)
    Springer
    Annals of hematology 52 (1986), S. 237-242 
    Details
    ISSN: 1432-0584
    Keywords: Acute myeloid leukaemia ; Granulocyte myeloperoxidase ; Neutrophil alkaline phosphatase-relapse-remission
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serial determinations of MPO and NAP activities in granulocytes were performed during the preremission phase and the remission phase in patients with AML. Of 18 patients examined during the preremission period, 9 showed an increased number of MPO deficient PMN. Complete remission was attained in 4 of these, in 3 the number of abnormal granulocytes changed to normal 7, 7 and 14 days before and in 1 simultaneously with the attainment of complete remission. In the other patients no changes in granulocyte MPO activity occurred during the preremission period. All 20 patients examined during complete remission showed a normal MPO activity in granulocytes. Of eight patients, who at diagnosis had shown abnormal granulocyte MPO activity, three developed relapse. In two of these, an increased number of MPO deficient PMN reappeared two and eight months prior to and in one simultaneous with clinical and laboratory suspicion of relapse. A statistically significant relation between low NAP scores and an increased number of MPO deficient PMN was found (P=0.011). Serial determinations of MPO activities in PMN, although restricted to cases of AML with initially abnormal values, may prove helpful in predicting achievement of complete remission and may furthermore prove to be useful as an indicator of early relapse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00321083
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  • 15
    Electronic Resource
    Electronic Resource
    The prognostic significance of cytological, histological and cytogenetic findings in refractory anaemia (RA) and RA with sideroblasts (1987)
    Springer
    Annals of hematology 54 (1987), S. 231-238 
    Details
    ISSN: 1432-0584
    Keywords: Blast foci ; Clonal cytogenetic abnormalities ; Clonal evolution ; Karyotype shift ; “Myeloblasts” ; Myelodysplastic syndromes ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two independent observers performed a double review of cytological and histological bone marrow material obtained at diagnosis and during follow up in 34 patients with the myelodysplastic syndrome (MDS), subtypes refractory anaemia (RA) and RA with ringed sideroblasts (RA-S) (26 and 8 patients, respectively). Average values were used for the analyses. Data obtained at diagnosis confirmed earlier observations that a worse prognosis was indicated by high blast cell counts (P〈0.01), presence of blast foci and clonal cytogenetic abnormalities (P=0.08). Data obtained during follow up, in addition, showed that an increased probability of progression to FAB-subtype RA with an excess of blasts was related to both the occurrence of blast foci (P〈0.05) and the occurrence of new or additional clonal abnormalities (karyotype shift) (P〈0.01). The relationship between parameters investigated at diagnosis, during follow up, and in the pooled material, points to RA-S being a separate entity having a better prognosis than RA, and further substantiates an earlier observed relationship between blast cell accumulation and the frequency of cytogenetically abnormal metaphases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00594199
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  • 16
    Electronic Resource
    Electronic Resource
    Renal hypertrophy in experimental diabetes: A comparison to compensatory hypertrophy (1978)
    Springer
    Diabetologia 14 (1978), S. 325-328 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; hypertrophy ; kidney ; nephrectomy ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kidney growth seen after the induction of experimental diabetes in rats has been compared to the compensatory renal growth after one-sided nephrectomy. After five days the kidney weight had increased from 650 ± 15 mg in a group of controls to 778 ± 21 mg in diabetic rats, and 764 ±17 mg in unilaterally nephrectomised rats. The increased weight was in both groups reflected in an increased DNA content and increased RNA/DNA and protein/DNA ratios. In a group of rats made diabetic and nephrectomised at the same time, kidney weight increased to 953 ± 22 mg after five days. When rats were unilaterally nephrectomised after 20 days of untreated diabetes, compensatory growth was much more pronounced than in non-diabetic rats, kidney weight rising from 780 ± 21 to 1144 ± 39 mg in five days. Similarly, in rats with established compensatory renal hypertrophy, diabetes induced a very rapid growth of the remaining kidney (1226 ± 46 mg after five days).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01223024
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  • 17
    Electronic Resource
    Electronic Resource
    Growth hormone enhances basement membrane thickening in experimental diabetes (1978)
    Springer
    Diabetologia 15 (1978), S. 487-489 
    Details
    ISSN: 1432-0428
    Keywords: Growth hormone ; diabetic microangiopathy ; basement membrane thickening ; experimental diabetes ; glomerular basement membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Injection of porcine growth hormone (200 μg) or saline 5 days a week for 16 to 20 weeks in streptozotocin-diabetic rats showed that compared to saline growth hormone produced a 2 1/2-fold larger increase in glomerular capillary basement membrane thickness (2p=0.027). The possible significance of this effect of an elevated level of growth hormone for diabetic microangiopathy is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02342875
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  • 18
    Electronic Resource
    Electronic Resource
    Renal hypertrophy in experimental diabetes: Relation to severity of diabetes (1977)
    Springer
    Diabetologia 13 (1977), S. 141-143 
    Details
    ISSN: 1432-0428
    Keywords: Blood glucose ; diabetes ; DNA ; hypertrophy ; kidney ; rat ; Streptozotocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Streptozotocin diabetic rats have larger kidneys than non-diabetic rats. In the present study the rate of kidney growth during the first seven days of diabetes was correlated with the blood glucose concentration. Over a wide range of blood glucose concentrations (116–340 mg/100 ml) the kidney weight, protein content and protein/DNA ratio were closely correlated with the glucose values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00745142
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  • 19
    Electronic Resource
    Electronic Resource
    Absence of hydrocephalus in spite of impaired cerebrospinal fluid absorption and severe intracranial hypertension (1987)
    Springer
    Acta neurochirurgica 86 (1987), S. 93-97 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four patients are described presenting papilloedema, increased pressure and reduced CSF absorption—caused by either spinal tumours, leptomeningeal carcinomatosis or encephalitis. Remarkably they all had a normal CT without signs of hydrocephalus. A 24-hour intracranial pressure monitoring showed a mean pressure of 30–35 mm Hg, recurrent plateau waves and high occurrence of B waves. Conductance to CSF outflow studied by a constant perfusion test was severely reduced 0.010–0.026mlmin−1mm Hg−1 (normal 〉 0.12ml mm Hg−1 min−1). Despite these findings no ventricular enlargement was seen on serial CT scans. The reason therefore remains unknown. Disappearance of papilloedema and a variable clinical improvement followed shunt-insertion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402291
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  • 20
    Electronic Resource
    Electronic Resource
    Growing skull fracture — Rupture of coronal suture caused by vacuum extraction (1987)
    Springer
    Neuroradiology 29 (1987), S. 502-502 
    Details
    ISSN: 1432-1920
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341755
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