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  • 1
    Digitale Medien
    Digitale Medien
    Isolation and identification of spermic acid, N,N′ -bis (2-carboxyethyl)-1,4-diaminobutane, from bovine brain (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 22 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04305.x
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  • 2
    Digitale Medien
    Digitale Medien
    Distribution of putreanine in organs of rats and rabbits (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb00211.x
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  • 3
    Digitale Medien
    Digitale Medien
    Immunohistochemical demonstration of carbonic anhydrase III and muscle-specific enolase in paraffin-embedded human skeletal muscle sections (1985)
    Springer
    Acta neuropathologica 68 (1985), S. 74-76 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Muscle ; Carbonic anhydrase ; Enolase (phosphopyruvate hydratase) ; Paraffin ; Histocytochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We have demonstrated the histochemical fiber types of human skeletal muscle in paraffin sections by the immunohistochemical method, together with compatible observations previously made in frozen sections that carbonic anhydrase III is mainly localized in type 1 fibers (Shima et al. 1983), and muscle-specific enolase in type 2 fibers (Ibi et al. 1983). This method is useful to analyze the fiber types when frozen muscle samples at biopsy or autopsy cannot be obtained.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688959
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  • 4
    Digitale Medien
    Digitale Medien
    Adducin: structure, function and regulation (2000)
    Springer
    Cellular and molecular life sciences 57 (2000), S. 884-895 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Key words. Membrane skeleton; adducin; spectrin; actin.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract. Adducin is a ubiquitously expressed membrane-skeletal protein localized at spectrin-actin junctions that binds calmodulin and is an in vivo substrate for protein kinase C (PKC) and Rho-associated kinase. Adducin is a tetramer comprised of either α/β or α/γ heterodimers. Adducin subunits are related in sequence and all contain an N-terminal globular head domain, a neck domain and a C-terminal protease-sensitive tail domain. The tail domains of all adducin subunits end with a highly conserved 22-residue myristoylated alanine-rich C kinase substrate (MARCKS)-related domain that has homology to MARCKS protein. Adducin caps the fast-growing ends of actin filaments and also preferentially recruits spectrin to the ends of filaments. Both the neck and the MARCKS-related domains are required for these activities. The neck domain self-associates to form oligomers. The MARCKS-related domain binds calmodulin and contains the major phosphorylation site for PKC. Calmodulin, gelsolin and phosphorylation by the kinase inhibit in vitro activities of adducin involving actin and spectrin. Recent observations suggest a role for adducin in cell motility, and as a target for regulation by Rho-dependent and Ca2+-dependent pathways. Prominent physiological sites of regulation of adducin include dendritic spines of hippocampal neurons, platelets and growth cones of axons.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00000731
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  • 5
    Digitale Medien
    Digitale Medien
    Plasma and right auricle concentrations of atrial natriuretic polypeptide in children with cardiac diseases (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 485-489 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Atrial natriuretic polypeptide ; Cardiac disease
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To investigate the atrial natriuretic polypeptide (ANP) levels in congenital heart diseases, we measured plasma immunoreactive ANP (ir-ANP) in 29 patients with left-to-righ shunt, and right auricle ir-ANP in 25 patients who underwent operation. The levels of ir-ANP in the pulmonary artery correlated with that in the femoral vein (r=0.95, P〈0.001), mean pulmonary arterial pressure (r=0.74, P〈0.001) and right atrial pressure (r=0.53, P〈0.01). The right auricle ir-ANP level was high in patients with heart failure combined with pressure or volume overload of the right atrium, as observed in tricuspid atresia, complete endocardial cushion defect, and total anomalous pulmonary venous drainage. These results suggest that the production of ANP in the atrium increases as a compensatory or secondary response to persistent release of ANP into the circulation in cardiac diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00441972
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  • 6
    Digitale Medien
    Digitale Medien
    Late-onset acid maltase deficiency associated with intracranial aneurysm (1988)
    Springer
    Journal of neurology 235 (1988), S. 371-373 
    Details
    ISSN: 1432-1459
    Schlagwort(e): Acid maltase deficiency ; Aneurysm ; Smooth muscle cell
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The autopsy findings in a patient with late-onset acid maltase deficiency who died following rupture of a basilar artery aneurysm are reported. The patient developed muscular weakness and wasting at the age of 20 years and died 9 years later after suddenly falling into a coma. At autopsy a giant fusiform aneurysm was found in the basilar artery which had ruptured at the base of the pons, leading to a large haematoma in the pons. The cerebral arteries and arterioles showed extensive vacuolar degeneration of smooth muscle cells in the media. It is suggested that the aneurysm was induced by fragility of the arterial wall due to this smooth muscle change.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00314237
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  • 7
    Digitale Medien
    Digitale Medien
    Evolutionary features of chondriome divergence in Triticum (wheat) and Aegilops shown by RFLP analysis of mitochondrial DNAs (2000)
    Springer
    Theoretical and applied genetics 100 (2000), S. 221-231 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Key words Mitochondrial DNA ; RFLP analysis ; Triticum ; Aegilops ; Plasmon phylogeny
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract  The first comprehensive analysis was made of restriction fragment length polymorphism (RFLP) of the mitochondrial (mt) DNA of two related genera, Triticum (wheat) and Aegilops. This led to clarification of the nature of mtDNA variability and the inference of the phylogeny of the mitochondrial genomes (=chondriome). Forty-six alloplasmic lines and one euplasmic line of common wheat (2n = 42, genomes AABBDD) carrying plasmons (cytoplasmic genomes) of 47 accessions belonging to 33 species were used. This consisted of nearly all the Triticum and Aegilops species. RFLP analysis, carried out with seven mitochondrial gene probes (7.0 kb in total) in combination with three restriction endonucleases, found marked variation: Of the 168 bands detected, 165 were variable (98.2%), indicative that there is extremely high mtDNA variability in these genera. This high variability is attributed to the variation present in the intergenic regions. Most of the variation was between chondriomes of different plasmon types; only 8 bands (4.8%) between those of the same plasmon types were variable, evidence of clear chondriome divergence between different plasmon types. The first comprehensive phylogenetic trees of the chondriome were constructed on the basis of genetic distances. All but 1 of the polyploids had chondriomes closely related to those of 1 putative parent, indicative of uniparental chondriome transmission at the time of polyploid formation. The chondriome showed parallel evolutionary divergence to the plastome (chloroplast genome). Use of a minimum set of 3 mtDNA probe-enzyme combinations is proposed for tentative plasmon type identification and the screening of new plasmon types in those genera.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001220050030
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