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  • 11
    Electronic Resource
    Electronic Resource
    Disposition of β-methyldigoxin in man (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 105-114 
    Details
    ISSN: 1432-1041
    Keywords: Methyldigoxin ; excretion ; deep compartment ; O-demethylation ; glycosides ; metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The time course of radioactivity in plasma and the excretion in urine and faeces over 7 days were determined in 12 healthy subjects after single oral and intravenous doses of a solution of3H-β-methyldigoxin. 62.2±2.1 and 29.0±5.2 per cent of the dose were excreted in urine and faeces, respectively, within 7 days of intravenous administration, compared with 55.2±2.8 and 28.6±5.7 per cent after oral administration. This indicates almost complete absorption of the glycoside when given in solution. 12 hours after its administration a pseudo-distribution equilibrium was reached and the average half life of tritiated compounds was 1.3 days. By 48 – 96 hours after treatment the average half life was 2.8 days. O-demethylation was revealed as the main metabolic degradation step in man. The rate of Demethylation was higher after oral than i.v. administration. Thus, only 31% of the radioactivity excreted in the urine consisted of unchanged β-methyldigoxin after oral administration compared to 51% after i.v. dosing. Only traces of bis- and monoglycosides were excreted in urine, but there were considerable amounts in faeces, where they accounted for more than 35% of the total excretion. Up to 40% of the radioactivity in plasma and urine consisted of polar conjugates during the first 12 hours after administration of β-methyldigoxin. The mono- and bisglycosides were identified as the main products of conjugation. During the 7 days approximately 15% of the administered dose was metabolized by splitting off glycosidic bonds and conjugation to polar compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614005
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  • 12
    Electronic Resource
    Electronic Resource
    Acrodermatitis enteropathica: Recent findings concerning clinical features, pathogenesis, diagnosis and therapy (1976)
    Springer
    European journal of pediatrics 121 (1976), S. 247-261 
    Details
    ISSN: 1432-1076
    Keywords: Acrodermatitis enteropathica ; Small bowel ; Oxyquinoline ; Metabolism of fatty acids ; Paneth cells ; Zinc deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 2 Geschwistern, einem Jungen und einem Mädchen, wurde die Diagnose der Acrodermatitis enteropathica (AE) im Alter von 10 bzw. 6 Wochen gestellt. Bis auf eine Blutsverwandtschaft, die 5 Generationen zurückliegt, ist die Familienanamnese anauffällig. Beide Kinder boten bei Diagnosestellung die für AE typischen Hautveränderungen. Symptome von seiten des Magen-Darm-Kanals waren weniger ausgeprägt und traten mit zunehmendem Alter in den Hintergrund. Bei dem jüngeren Patienten konnten während eines Rezidivs eine Erniedrigung des Serumspiegels der Ölsäure (18:1) sowie eine leichte Vermehrung der Linolsäure (18:2) festgestellt werden, während die Arachidonsäure (20:4) vermindert war. Bei beiden Patienten waren die Serumzinkspiegel mit und ohne Oxychinolinbehandlung deutlich erniedrigt. Eine Substitutionstherapie mit Zinkaspertat brachte weder eine klinische Besserung noch einen wesentlichen Anstieg des Serumzinkspiegels. Durch Gabe von Zinksulfat konnten eine völlige Remission der Hautveränderungen sowie eine weitgehende Normalisierung der Serumzinkspiegel erreicht werden. Untersuchungen der Dünndarmschleimhaut zeigten lichtmikroskopisch keine Besonderheiten. Elektronenmikroskopisch fanden sich in den Enterocyte sogenannte multi-vesicular bodies. Die Paneth-Zellen zeigten teilweise unregelmäßig geformte, inhomogene Strukturen im Cytoplasma. Die pleomorphen Sekretgraula wanen plump und groß und wiesen eine ausgeprägte Heteromorphie ihrer Matrix auf. Da bei Ratten unter zinkarmer Ernährung ähliche ultrastrukturelle Veränderungen bekannt sind, muß durch weitere Untersuchungen geklärt werden, ob die Veränderungen in den Paneth-Zellen typisch für die AE sind. Die adäquate Therapie der AE besteht zur Zeit in der Substitution von Zink. Dadurch wurde die mit toxischen Augenschädigungen belastete Therapie mit Oxychinolinen überflüssig.
    Notes: Abstract Acrodermatitis enteropathica (AE) was diagnosed in 2 siblings, boy and girl, at the age of 10 and 6 weeks. The family history is unremarkable except for consanguinity 5 generations previously. The clinical symptoms of the 2 patients conformed to the known features of AE, the gastrointestinal involvement loosing its significance with increasing age. In one patient in a stage of exacerbation the serum level of oleic acid (18:1) was lowered and of linoleic (18:2) acid slightly increased while that of arachidonic acid was decreased (Fig. 4). In both patients the serum zinc levels were significantly lowered. Under substitution with ZnSO4 the clinical condition improved and the serum zinc levels returned to normal. Histologically the small bowel mucosa was practically normal. Ultrastructural examination of jejunal biopsies revealed rather unspecific changes in the enterocytes in the form of numerous multivesicular bodies. The Paneth cells sometimes contained irregularly formed inhomogeneous structures within their cytoplasm. In addition the secretory granules varied in size and displayed a granular heteromorphic matrix. Frequently they were confluent and formed giant granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443018
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  • 13
    Electronic Resource
    Electronic Resource
    Laser diagnostic in molecular beams (1975)
    Springer
    Applied physics 8 (1975), S. 65-70 
    Details
    ISSN: 1432-0630
    Keywords: Nozzle beams ; Laser Diagnostic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The output from a stabilized, tunable single-mode laser is split into two beams which cross the molecular beam perpendicularly and at an angle of β to the beam axis. Tuning the laser frequency across the unshifted and Doppler-shifted absorption profile of the molecular transition yileds the velocity distribution of the molecules in the beam for individual quantum states. The internal state distribution among vibrational and rotational levels in the beam can be determined by comparing the fluorescence simultaneously induced in the beam and in a cell with molecules in thermal equilibrium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00883672
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  • 14
    Electronic Resource
    Electronic Resource
    Serum-cholesterol-lowering effect of metronidazole and possible mechanisms of action (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 279-281 
    Details
    ISSN: 1432-1440
    Keywords: Metronidazole ; Bile acids ; Cholesterol absorption ; Serum cholesterol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five patients with Crohn's disease long-term therapy with metronidazole (400 mg b.i.d.) was followed by a significant reduction of total serum cholesterol from 179 mg/dl to 156 mg/dl, 134 mg/dl, and 143 mg/dl, after 2–4 months, 6 months, and 9–12 months, respectively. Lipoprotein analysis before and after 3 weeks of administration of metronidazol (400 mg/day) to five normolipemic volunteers revealed that LDL-cholesterol was reduced by 21% (P〈0.05), whereas HDL-cholesterol remained unchanged. Biliary secretion of cholesterol and bile acids were reduced by 13% and 20% (P〈0.05), respectively, which might suggest a decreased sterol synthesis. The amount and percentage of intestinal cholesterol absorption were decreased by 33% and 22% (P〈0.05). Thus, a possible decrease in sterol synthesis and a reduction of cholesterol absorption might be responsible for the serum-cholesterol-lowering effect of metronidazole. However, caution should be taken when considering metronidazole for long-term treatment of patients with hypercholesterolemia due to possible side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731475
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  • 15
    Electronic Resource
    Electronic Resource
    Der Verschluß des Aquaeductus cochleae für Perilymphuntersuchungen am Meerschweinchen (1979)
    Springer
    European archives of oto-rhino-laryngology and head & neck 224 (1979), S. 257-265 
    Details
    ISSN: 1434-4726
    Keywords: Guinea pig ; Cochlear aqueduct ; Round window membrane ; Cerebrospinal fluid ; Perilymph ; Protein concentration ; Electrophysiology ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To prevent the perilymph (guinea pig) from contamination with CSF during the sampling the aqueductus cochleae (AC) was blocked by injection of tissue adhesive into the meningeal aperture. The control of an exact blockage of AC was carried out by examination of perilymph-outflow after opening the cochlea (injection of fluorescein-Na into the CSF-space), analysis of perilymphprotein-concentration, macroscopic and microscopic examination of the temporal bones. In all cochleae we have found the same morphological structures, notwith-standing whether the AC was blocked (for a time from 30 min to 7 weeks) or not: The cochlear aqueduct is filled with a mesh of mesenchymal tissue, which grows more dense towards the cochlear aperture and continues into the round window membrane. From scala tympani the AC is always limited by one layer of cells forming a sort of membrane (under light microscope). It seems possible that CSF moves in the inner of the round window membrane between AC and subepithelian space of middle ear mucosa, whereas perilymph of scala tympani is not in direct contact with the flow of CSF. The scala tympanic side of the round window membrane may be a big area for diffusion and there also may be an exchange between CSF and perilymph. The outflow of CSF into the cochlea after experimental opening of the cochlea is an artifact, caused by damage of pressure equilibration between CSF-space and cochlea. 30 min and 5–7 weeks after blockage no morphological and electrophysiological alterations from those of the control ears were to be seen. The protein concentration, however, increased significantly 5–7 weeks after blockage from normally about 200 mg/100 ml to almost the double especially in the scala tympani (see Table 1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01108783
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  • 16
    Electronic Resource
    Electronic Resource
    Versuche zur medikamentösen Beeinflussung der Lärmschwerhörigkeit (1976)
    Springer
    European archives of oto-rhino-laryngology and head & neck 212 (1976), S. 171-177 
    Details
    ISSN: 1434-4726
    Keywords: Dipyridamol ; Allopurinol ; Noise-induced Cochlear Damage/Lärmhörschäden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dipyridamol has in addition to a coronardilatating effect an antithrombotic one too. Moreover it facilitates the release of O2 from haemoglobin by increase of the concentration of 2,3-diphosphoglycerate in the erythrocytes. Allopurinol causes a potential resynthesis of ATP in the cells by inhibition of the metabolism of uric acid. Both substances therefore seemed to be suitable for a medicamental therapy of the noise-induced cochlear damage. The expected favourable effect of Dipyridamol and Allopurinol on the organ of Corti after sound exposure (RMP-measurement before and after exposure to pure tone 120 dB SPL) however had not been confirmed by experiment on animals (guinea Pig).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00456694
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  • 17
    Electronic Resource
    Electronic Resource
    Long-term occupational inhalation of organic dust — Effect on pulmonary function (1978)
    Springer
    International archives of occupational and environmental health 42 (1978), S. 119-127 
    Details
    ISSN: 1432-1246
    Keywords: Organic dusts ; Allergic alveolitis ; Bird fancier's lung ; Immunology ; Counter-immunoelectrophoresis ; Sensitisation ; Pulmonary function diagnosis ; Ventilation ; Respiratory mechanics ; Diffusion ; Distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies to detect disorders of pulmonary function were performed on 42 workers at a poultry farm. All the subjects were exposed to organic dusts and sensitised to poultry antigens. Typical signs of bird fancier's lung were recorded in two of them. Included in all examinations were immunological diagnosis by means of counter-immunoelectrophoresis, systematic interviewing for case histories, and registration of respiratory symptoms. Pulmonary function was recorded by means of the following techniques: analysis of ventilation (flow-volume indices), respiratory mechanics of the larger airways and lung (body box plethysmography, oesophago-balloon technique), respiratory mechanics of the small airways (closing volume), distributional analysis, diffusion analysis, and blood gas analysis. A disorder of pulmonary function was recordable in 40 sensitised individuals. Such disorder being characterised by obstruction of the larger airways and slight inhomogeneity. The small airways were not narrowed. No restriction nor disturbed diffusion were established. The severity of obstruction was found to be related to the degree of sensitisation. The following more clearly pronounced changes in terms of functional diagnosis were recordable from two poultry workers with allergic alveolitis: obstruction of larger airways with concomitant restriction, marked inhomogeneity, and disorder of diffusion. The disorders, relatively discrete, led to mild PO2-reduction in sensitised individuals, whereas mild hypoxaemia was recorded from subjects with allergic alveolitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01297550
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  • 18
    Electronic Resource
    Electronic Resource
    Perilymphatische Perfusion der Kochlea mit einer Fluorokarbon-Emulsion (1978)
    Springer
    European archives of oto-rhino-laryngology and head & neck 220 (1978), S. 299-301 
    Details
    ISSN: 1434-4726
    Keywords: Fluorocarbon ; O2-Solubility ; Perfusion ; Cochlea ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Because oxygen is at least ten times as soluble in fluorocarbon liquids as in plasma or saline, we investigated the principle possibility of perilymphatic perfusion of the cochlea with perfluortributylamin. Our experiments show that fluorocarbons in spite of the excellent O2-solubility in it are not suitable for the perilymphatic perfusion due to their physical properties (density 1.91 g/ml, non-solubility in water, necessity and difficulties of emulsification).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455367
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  • 19
    Electronic Resource
    Electronic Resource
    The effect of vibrational bond stretching on rotational inelastic electron-molecule scattering (1988)
    Springer
    The European physical journal 10 (1988), S. 247-252 
    Details
    ISSN: 1434-6079
    Keywords: 34.50.Ez ; 34.50.Pi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Differential cross sections for state-to-state rotationally inelastic electron-Na2 scattering, with the molecule being in the vibrational levelv′'=31, are measured at a collision energy of 150 eV. Angular momentum transfer of up to Δj=26 is observed, which is even more than previously obtained for the vibrational ground statev′'=0. Good agreement is found with theoretical results from a spectator scattering model. This work, in general, elucidates the role of vibrational excitation in collision dynamics under vibrationally sudden conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01384859
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  • 20
    Electronic Resource
    Electronic Resource
    Zur Kenntnis der Verbindungen des zwei- und dreiwertigen Vanadins. I. Über die Ammoniakate des Vanadin(III)-chlorids (1950)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 262 (1950), S. 223-228 
    Details
    ISSN: 0372-7874
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1.Es wurde das Verhalten von VCl3 gegen NH3 untersucht. Dabei fanden sich Ammoniakate mit 12, 7, 6, 5, 3 und 2 NH3. Die Bildungswärmen wurden berechnet.2.Die Ergebnisse sind bei Temperaturen oberhalb Zimmertemperatur mit Beobachtungen von EPHRAIM und AMMANN im Einklang; dagegen konnten die Angaben von J. MEYER und BACKA über die Entstehung von Vanadinnitrid bei der Einwirkung von NH3-Gas auf VCl3 nicht bestätigt werden.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19502620128
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