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  • 1
    Electronic Resource
    Electronic Resource
    286. Die intraarterielle Calciuminjektion als Therapie der Flußsäureverätzung (1980)
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 602-602 
    Details
    ISSN: 1435-2451
    Keywords: HF acid burns ; Intra-arterial Ca injections ; Wound healing ; HF-Verätzung ; Intraarterielle Ca-Injektion ; Wundheilung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Flußsäureverätzungen, die einen progressiv gewebezerstörenden Charakter zeigen, werden z. Z. behandelt durch lokales Umspritzen mit Ca-Gluconat. In einer tierexperimentellen Untersuchung wird gezeigt, daß die intraarterielle Calciuminjektion in die einen verätzten Bezirk versorgende Zentralarterie als Therapie überlegen ist und zu einer schnelleren und nachhaltigeren Unterbrechung des HF-spezifischen Zerstörungsprozesses führt. Gute Behandlungsergebnisse bei HF-Verätzungen durch intraarterielle Injektion von unverdünntem 20%igem Ca-Gluconat finden wir in der klinischen Anwendung bestätigt.
    Notes: Summary The worldwide accepted treatment of HF burns, which presents major problems because of progressive necrosis of burned areas, is the local infiltration with ionized calcium. - In experimental studies we proved that intra-arterial injection of calcium into the main artery of a burned area is the superior therapy in terms of earlier and more effective prevention of the HF-specific destruction. - The same good results were achieved clinically by intra-arterial injections of undiluted 20% Ca gluconate in patients with HF burns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292251
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  • 2
    Electronic Resource
    Electronic Resource
    Germinal center cell lymphomas: Prognostic significance of their histopathological differentiation (1981)
    Springer
    Annals of hematology 43 (1981), S. 193-200 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin lymphoma ; Centrocytic lymphoma ; Centroblastic-centrocytic lymphoma ; Centroblastic lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical data of 48 patients with centrocytic, 83 patients with centroblastic/centrocytic and 64 patients with centroblastic lymphoma who had entered a prospective multicenter study of the Kiel Lymphoma Study Group since October 1975 were compared. Advanced (stage IV) disease at time of diagnosis, predominantly due to bone marrow infiltration, was most frequent in centrocytic (69% of patients) and in centroblastic/centrocytic (51% of patients) lymphomas as compared to only 28% of patients with centroblastic lymphoma. High survival probability of patients with localized centrocytic and centroblastic/centrocytic lymphomas after radiotherapy, contrasting with a worse prognosis of corresponding patients with centroblastic lymphoma, is compatible with the classification of these lymphoma entities as neoplasias of low-grade malignancy. However, as shown by this prospective and previous retrospective trials overall survival probability of patients with advanced centrocytic lymphoma was inferior to that observed in corresponding patients with centroblastic/centrocytic lymphoma. These findings suggest the possibility that patients with advanced centrocytic lymphoma occupy an intermediate position between typical low-grade and typical high-grade malignant non-Hodgkin lymphomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363889
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  • 3
    Electronic Resource
    Electronic Resource
    Posterpräsentationen 45 (1983)
    Springer
    Archives of gynecology and obstetrics 235 (1983), S. 464-466 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02428758
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  • 4
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1982)
    Springer
    OR spectrum 4 (1982), S. 118-128 
    Details
    ISSN: 1436-6304
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740470
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  • 5
    Electronic Resource
    Electronic Resource
    Intercellular junctions in the human fetal membranes (1983)
    Springer
    Anatomy and embryology 166 (1983), S. 103-120 
    Details
    ISSN: 1432-0568
    Keywords: Human fetal membranes (amnion, chorion laeve) ; Intercellular junctions ; Freeze-fracture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Freeze-fracture replicas of the human reflected and placental amnion and chorion laeve at term were studied in order to give a systematic survey of the nature and extension of the intercellular junctions in the fetal membranes. No differences could be detected between the reflected and placental amniotic epithelium. In both the replicas never displayed plasma membrane differentiations typical of occluding junctions, while communicating junctions were occasionally and desmosomes frequently seen. In the chorionic trophoblast maculae occludentes, communicating junctions and desmosomes were regularly encountered. It is assumed that the maculae occludentes are remnants of occluding junctions which early in gestation possibly seal off the chorionic cavity; it appears improbable that they contribute significantly to the permeability properties of the chorionic trophoblast, since it is known from previous ultrastructural studies that large open intercellular channels cross the chorionic trophoblast. Thus the absence of occluding junctions, which could act as effective permeability barriers, in both epithelial components of the fetal membranes suggests that the factors able to influence the amniotic fluid turnover or the paraplacental protein exchange are the geometrical relationships and physico-chemical properties of the intercellular channels in the amniotic epithelium and chorionic trophoblast. In addition, communicating junctions were present between fibroblasts in the chorion laeve but not in the amnion, possibly indicating differences in the functional state of these cells and/or their extracellular microenvironments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317947
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  • 6
    Electronic Resource
    Electronic Resource
    Analyse des dynamischen Verhaltens räumlicher Gelenkvierecke (1982)
    Springer
    Archive of applied mechanics 52 (1982), S. 47-61 
    Details
    ISSN: 1432-0681
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Summary The equations of motion for the general spatial four-bar mechanism which appears in many technical applications, are derived by means of the theorems of momentum and moment of momentum. Thus, the reaction forces in the bearings and the combining hinges can be calculated simultaneously. Furthermore, the dynamical behaviour of the four-bar mechanism depends on the technical realization of the hinged articulations. The equations of motion are solved numerically, and the procedure is demonstrated by an example.
    Notes: Übersicht Für ein allgemeines räumliches Gelenkviereck, das in vielen technischen Anwendungen als Antriebselement oder Übertragungsglied auftritt, werden mit Hilfe von Impuls- und Drallsätzen die Bewegungsgleichungen aufgestellt, um so gleichzeitig die praktisch interessierenden Lager- und Gelenkreaktionen mit zu erfassen. Dabei hängt das dynamische Verhalten des Gelenkviereckes wesentlich von der technischen Ausführung der gelenkigen Verbindungen ab. Die Arbeitsweise des zur Lösung der Bewegungsgleichungen entwickelten numerischen Verfahrens wird an einem Beispiel demonstriert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00536312
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  • 7
    Electronic Resource
    Electronic Resource
    Principles and present status of a prospective multicenter study on the clinical relevance of the kiel classification (1981)
    Springer
    Annals of hematology 43 (1981), S. 155-166 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin lymphoma ; Kiel classification ; Low-grade malignancy ; High-grade malignancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On the basis of the retrospective analysis of 405 patients, suggesting the clinical relevance of the Kiel classification of non-Hodgkin lymphomas (NHL), a prospective multicenter study was started on October 1st, 1975, by the Kiel Lymphoma Study Group in order to further clarify the clinical and prognostic features of the different lymphoma entities defined by this histopathologic scheme. Diagnostic protocol provides initial staging evaluation according to a modification of the Ann Arbor classification. Therapeutic approach is based on the hypothesis that, like Hodgkin's disease, NHL originate, at least in part, as localized lymphatic or extralymphatic tumors. Thus, extended field irradiation is performed in stages I and II (except for lymphoblastic lymphoma in children and young adults) whereas in the more advanced stages III and IV (except for stage III of centroblastic-centrocytic lymphoma) chemotherapy with additional radiotherapy is applied. Until June 1979, 815 patients entered the study (69.7% with NHL of low-grade malignancy). For the interim evaluation underlying the present and the other papers of this series data of 511 patients were available. Survival of patients with NHL of low-grade malignancy significantly exceeds that of patients with NHL of high-grade malignancy. NHL with good prognosis such as chronic lymphocytic leukaemia and centroblastic-centrocytic lymphoma can be differentiated from NHL with a poor course such as lymphoblastic and immunoblastic lymphomas. In addition, the existence of a third group with an intermediate prognosis comprising centrocytic and centroblastic lymphomas and, possibly, also LP immunocytoma is suggested. However, different initial slope of survival curves shows that this latter group of NHL is not homogeneous with regard to prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363886
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  • 8
    Electronic Resource
    Electronic Resource
    Clinical and prognostic heterogeneity of non-hodgkin lymphomas of high-grade malignancy (1981)
    Springer
    Annals of hematology 43 (1981), S. 201-211 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin lymphoma ; High-grade malignancy ; Lymphoblastic lymphoma ; Immunoblastic lymphoma ; Centroblastic lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Comparison of clinical data of 64 patients with centroblastic lymphoma, 55 patients with immunoblastic lymphoma and 31 patients with lymphoblastic lymphoma not only confirmed the original assumption of high-grade malignancy as proposed by the concept of the Kiel classification but also demonstrated distinct clinical differences, particularly between lymphoblastic lymphoma and the two other entities. Rapid lymph node enlargement as well as steep fall of survival curves within the first year after diagnosis were common characteristics. Bimodal age distribution, predominance of males and early generalization of disease were typical features of lymphoblastic lymphoma; elderly patients and patients with the unclassified subtypes of lymphoblastic lymphoma exhibited the worst prognosis. Whereas patients with centroblastic and immunoblastic lymphomas showed similar distribution of age, sex and initial stage of disease, patients with immunoblastic lymphoma presented more frequently with a reduced performance status and showed a poorer response to radio- and chemotherapy resulting in a worse prognosis discernible after the first year of follow-up. Generalization during course of the disease was significantly more frequent in immunoblastic than in centroblastic lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363890
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  • 9
    Electronic Resource
    Electronic Resource
    A simple test for urinary lactic acid (1980)
    Springer
    Intensive care medicine 6 (1980), S. 235-238 
    Details
    ISSN: 1432-1238
    Keywords: Lactic acidosis ; Hyperlactataemia ; Urinary lactic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A new simple rapid test for the detection of increased urinary lactic acid is described. The method depends on the transformation of lactic acid to acetaldehyde by cesium IV. Acetaldehyde reacts with sodium nitroprusside producing a blue color. Patients from an emergency ward and patients with experimentally induced hyperlactatemia have been screened with this test. The results confirm that there exists a correlation between blood and urinary lactate levels and that a clinically relevant hyperlactatemia is associated with an increased urinary lactate concentration which can be reliably detected with this test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01687164
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  • 10
    Electronic Resource
    Electronic Resource
    Parathyroid function and serum calcitonin in children receiving anticonvulsant drugs (1980)
    Springer
    European journal of pediatrics 133 (1980), S. 151-156 
    Details
    ISSN: 1432-1076
    Keywords: Calcitonin ; Parathyroid hormone ; Anticonvulsant bone disease ; Urinary cyclic AMP ; Urinary hydroxyproline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum calcitonin (CT) levels and other aspects of calcium metabolism were investigated in 40 epileptic children receiving long-term treatment with phenytoin and/or other anticonvulsant drugs, and in 38 age-matched controls. In the patients CT levels were significantly lower. Immunoreactive parathyroid hormone (iPTH) was significantly elevated exceeding the upper limit of controls in 11 patients. We also observed a highly significant correlation between iPTH and urinary cyclic AMP (cAMP) excretion but a lack of such a correlation with the renal handling of phosphate; this indicates to us a dissociation between cAMP production and phosphaturia. A significant correlation between iPTH levels and urinary hydroxyproline excretion points to a normal action of PTH on bone in the patients. The low CT levels are not due to hypocalcemia and may be directly attributed to the effects of anticonvulsant drugs. As the primary effect of CT is a direct inhibition of PTH induced calcium loss from bone, the drug-related low CT levels in association with secondary hyperparathyroidism possibly is an additional factor in anticonvulsant bone disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441584
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