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  • Chemistry  (47)
  • Keratinocyte  (3)
  • Lupus  (3)
  • Magnetic resonance imaging  (3)
  • 1
    ISSN: 0014-5793
    Keywords: Cornified envelope ; Keratinocyte ; Plasma membrane ; Transglutaminase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0014-5793
    Keywords: Keratinocyte ; Protein cross-linking ; Pseudo-envelope ; Transglutaminase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    FEBS Letters 258 (1989), S. 35-38 
    ISSN: 0014-5793
    Keywords: Keratinocyte ; Retinoic acid ; Transglutaminase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1437-160X
    Keywords: Key words Systemic lupus erythematosus ; Lupus ; Anti-dsDNA antibodies ; IgA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previously it has been suggested that the presence of antibodies against dsDNA of the IgA class may define a subset of systemic lupus erythematosus (SLE) patients suffering from nephritis and arthritis. Therefore, these autoantibodies were measured in sera of 352 patients with SLE, 81 blood donors, and 189 patients with rheumatoid arthritis using a new ELISA based on human recombinant dsDNA as antigen. IgA anti-dsDNA antibodies were found in 19.9% of the sera from patients with SLE, but in none of the sera from 81 normal controls and 189 patients with rheumatoid arthritis. The association of these autoantibodies with 31 clinical and 36 laboratory parameters was calculated. IgA anti-dsDNA antibodies were found to be associated with parameters of disease activity such as elevated erythrocyte sedimentation rate and consumption of complement component C3, and the clinical parameters vasculitis, acral necrosis and erythema, but not with nephritis and arthritis. Therefore, IgA anti-dsDNA antibodies define a subset of SLE patients, and monitoring of IgA anti-dsDNA antibodies may be helpful as a prognostic parameter in patients with SLE.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1437-160X
    Keywords: Key words SLE ; Lupus ; Anti-dsDNA antibodies ; IgM ; Nephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antibodies against dsDNA of the IgM class were measured in sera of 352 patients with systemic lupus erythematosus, 81 blood donors and 189 patients with rheumatoid arthritis using a new ELISA based on human recombinant dsDNA as antigen. IgM anti-dsDNA antibodies were found in 52.3% of the sera from patients with systemic lupus erythematosus, but in none of the sera from 81 normal controls and 189 patients with rheumatoid arthritis. The association of these autoantibodies with 31 clinical and 37 laboratory parameters was calculated. There was a highly significant negative correlation between IgM anti-dsDNA antibodies and nephritis as well as all the laboratory parameters indicating renal disease (elevated serum creatinine concentration, proteinuria, erythrocyte casts in the urine). IgM anti-dsDNA antibodies indicate protection of lupus patients against the development of lupus nephritis. Further experiments will show whether application of IgM anti-dsDNA antibodies is effective in treating lupus nephritis.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1437-160X
    Keywords: Key words SLE ; Lupus ; Rheumatoid factors ; Sicca syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The prevalence and clinical and laboratory associations of IgM, IgG and IgA rheumatoid factors (RF) were determined in 352 patients with systemic lupus erythematosus (SLE). IgM, IgG, and IgA class RF were detected in 17.9%, 20.5%, and 20.5% of the sera, respectively. RF were associated with sicca syndrome, hypergammaglobulinemia, high titer of antinuclear antibodies, anemia, SSA- and SSB-antibodies, and with the presence of HLA-DR3. RF correlated negatively with nephritis and livedo racemosa. Moreover, we observed an association of RF and parameters of inflammatory activity such as elevated erythrocyte sedimentation rate (ESR) and leukopenia. Analysis of immunoglobulin classes revealed that laboratory parameters of inflammatory activity, SSA- and SSB-antibodies and HLA-DR3 correlated with IgA RF only. IgA RF define a subgroup of SLE patients characterized by distinct autoimmune phenomena and high disease activity in the absence of nephritis.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Intrazerebrale Blutung ; Magnetresonanztomographie ; Hämosiderin ; Key words Intracerebral hematome ; Magnetic resonance imaging ; Hemosiderin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Increased use of gradient echo T2*- weighted gradient echo sequences in magnetic resonance imaging (MRI) of patients suffering from primary ICH called attention to foci of signal loss which were suggested to represent remnants of cerebral microbleeds. In a post mortem correlative MR and histopathological study we provide support for this notion. We found areas of signal loss on gradient echo T2*-weighted sequences in 7 out of 11 brains of patients who had died of intracerebral hematoma. Histopathologically, these areas represented hemosiderin deposits indicating previous extravasation of blood. To provide data about the prevalence of these MRI findings in a healthy elderly population a subgroup of participants of the Austrian Stroke Prevention Study was analyzed. We detected foci of signal loss on gradient echo T2*-weighted sequences in 18 out of 280 volunteers (6,4%). MR-based evidence of previous microbleeds may indicate a potentially higher risk of suffering from intracerebral bleeding which could have therapeutic implications for the treatment of acute stroke and for secondary prevention. This hypothesis will have to be tested in future prospective trials.
    Notes: Zusammenfassung Vermehrte Anwendung T2*-gewichteter Gradienten-Echo-Sequenzen bei Magnetresonanztomographie- (MRT-) Untersuchungen von Patienten nach einem intrazerebralen Hämatom machte auf kleine, hypointense Areale aufmerksam, von denen bisher nur angenommen wurde, daß sie abgelaufene Mikroblutungen darstellen. In einer Post-mortem-Studie mit MRT und vergleichenden histopathologischen Untersuchungen zeigen wir Daten, die diese Hypothese stützen. Bei 7 von 11 Patienten, die an primärem intrazerebralem Hämatom verstorben waren, fanden sich hypointense Areale in T2*-Gradienten-Echo-Sequenzen. Histopathologisch zeigten diese Areale Hämosiderin-Ablagerungen, welche auf abgelaufene Blutungen hinweisen. Um Aussagen über die Prävalenz dieser MRT-Befunde in einem Kollektiv klinisch unauffälliger Probanden mittleren Alters machen zu können, wurden Teilnehmer derÖsterreichischen Schlaganfall-Vorsorge-Studie untersucht. Bei 18 von 280 Probanden (6,4%) fanden sich Signalhypointensitäten in T2*-Gradienten-Echo-Sequenzen. Der MR-tomographische Nachweis abgelaufener Mikroblutungen könnte ein Hinweis auf ein erhöhtes zerebrales Blutungsrisiko sein, was therapeutische Konsequenzen für die primäre Therapie und Sekundärprophylaxe beim Schlaganfall haben könnte. Hierzu sind noch weitere prospektive Studien notwendig.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 40 (1998), S. 675-683 
    ISSN: 1432-1920
    Keywords: Key words Cortical dysplasia ; focal ; Magnetic resonance imaging ; Magnetic resonance spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied nine cases of focal cortical dysplasia (FCD) by MRI, with surface-rendered 3D reconstructions. One case was also examined using single-voxel proton MR spectroscopy (MRS). The histological features were reviewed and correlated with the MRI findings. The gyri affected by FCD were enlarged and the signal of the cortex was slightly increased on T1-weighted images. The gray-white junction was indistinct. Signal from the subcortical white matter was decreased on T1- and increased on T2-weighted images in most cases. Contrast enhancement was seen in two cases. Proton MRS showed a spectrum identical to that of normal brain.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging ; Superficial siderosis ; Central nervous system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We reviewed a 7-year series of brain MRI examinations to determine the frequency and clinical significance of superficial siderosis of the central nervous system (SS). SS was defined by widespread bilateral signal loss at the surfaces of the cerebral or cerebellar hemispheres, the brain stem and the spinal cord on T2-weighted images. Clinical data comprised a neurological examination of identified patients and a review of their case notes. Among 8843 consecutive studies we identified 13 (0.15 %) patients with MRI evidence of SS. Only 2 had symptoms or signs characteristic of SS, such as cerebellar ataxia, hearing loss, myelopathy and dementia. Haemosiderin deposition was most widespread in both symptomatic individuals. A definite cause for SS was detected in 9 patients (69 %). None of them had a full clinical picture of SS. These data indicate SS per se to be much more frequent than may be assumed from the literature. It appears to become symptomatic only with extensive amounts of widespread iron deposition which develop preferentially with cryptic or unidentified causes of bleeding.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 45 (1994), S. 21-28 
    ISSN: 0947-5117
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Microbial deterioration of materials - fundamentals: Mathematical modelling of destruction mechanismsModern trends in materials science require novel methods and strategies. The general aim is to describe by models the reactions occurring at the surface and within a solid. At the present time, however, it is only possible to derive, from the experimental work, mathematical relations, and this is not sufficient for a prediction of materials behaviour. On the basis of the three steps involved in the description of materials behaviour, i. e. rules of thumb, statistical evaluation of experimental data (including models developed for the presentation of reaction kinetics), and development of physical models (among others Monte Carlo simulations), these three steps and, in particular, the preliminary step of biocorrosion, i. e. biofilm formation, are discussed. Only physical models allow a prediction of reactions, although a prediction independent from experiment is not possible because of the unknown distributions of the acting energies and their possible fluctuations. Beyond that an outline is given of the description of corrosion reactions and crack propagation. A general problem, in particular in connection with biological reactions, is the lack of interdisciplinary education of scientists and engineers.
    Notes: Die moderne Entwicklung der Werkstoffwissenschaft bedingt einen Wandel in den Methoden und Strategien. Es wird angestrebt, die an und im Festkörper ablaufenden Reaktionen in Form von Modellen zu beschreiben. Gegenwärtig gelingt es aber nur, aus experimentellen Untersuchungen mathematische Zusammenhänge abzuleiten, womit eine Vorhersage des Werkstoffverhaltens mit theoretischen Mitteln nicht gelingt.Ausgehend von den drei Erkenntnisstufen zur Beschreibung des Werkstoffverhaltens, den Faustregeln, einer Auswertung von Experimenten mit statistischen Methoden, hierzu gehören auch reaktionskinetische Modellansätze, und der Entwicklung physikalischer Modelle, u.a. Monte-Carlo-Simulationen, werden diese insbesondere für die „Vorstufe“ der biokorrosiven Schädigung vorgestellt, der Biofilmbildng. Nur physikalische Modelle ermöglichen die „Voraussage“ von Reaktionsabläufen, wobei infolge der Unkenntnis der Verteilungen für die wirkenden Energien und deren möglichen Fluktuationen eine vom Experiment getrennte Voraussage nicht möglich ist.In einem Überblick wird darüber hinaus auch auf die Beschreibung von Korrosionsreaktionen und das Rißwachstum eingegangen. Ein generelles Problem, insbesondere im Zusammenhang mit biologischen Reaktionsabläufen, stellt die nicht fachgrenzenübergreifende Ausbildung von Naturwissenschaftlern and Ingenieuren dar.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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