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  • 1
    Electronic Resource
    Electronic Resource
    Erythema Migrans Borreliosis: An HLA-associated Disease? (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 539 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb31889.x
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  • 2
    Electronic Resource
    Electronic Resource
    Coexistence of hereditary coproporphyria and epilepsy: Coproporphyrinogen oxidase deficiency in liver and kidney (1981)
    Springer
    Journal of neurology 226 (1981), S. 25-33 
    Details
    ISSN: 1432-1459
    Keywords: Porphyria acute hepatic ; Coproporphyria hereditary ; Coproporphyrinogen oxidase ; Epilepsy ; Tetraplegia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine akute hepatische Porphyrie vom Typ der hereditären Koproporphyrie wurde bei einer 28jährigen Frau mit Tetraplegie und Atemlähmung erkannt, bei der sechs Jahre vorher eine Epilepsie diagnostiziert wurde. Die Porphyriediagnose basiert auf einer hohen Ausscheidung von δ-Aminolävulinsäure, Porphobilinogen und Koproporphyrin III im Urin sowie von Koproporphyrin III in der Galle. Die Aktivität der Koproporphyrinogen-Oxidase war in der Leber und Niere vermindert, während die Aktivität der δ-Aminolävulinsäure-Synthase stark erhöht war. Die Patientin war über zwölf Jahre krank: Neurologisch-psychiatrische, gastroenterologische, gynäkologische und urologische Diagnosen wurden getroffen, denen entsprechende therapeutische Maßnahmen einschließlich von neun Operationen folgten.
    Notes: Summary An acute hepatic porphyria of the hereditary type was found in a 28-year-old woman with tetraplegia and respiratory paralysis, who had had epilepsy diagnosed 6 years previously. The diagnosis of porphyria was established by high excretion of urinary δ-aminolevulinic acid, porphobilinogen and coproporphyrin III as well as of biliary coproporphyrin III. Coproporphyrinogen oxidase activity was decreased in liver and kidney, whereas δ-aminolevulinic acid synthase activity was much increased. The patient had been ill for the past 12 years: neurologic-psychiatric, gastroenterologic, gynaecologic, and urologic diagnoses were made and followed by corresponding therapeutic measures including nine operations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313315
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of high-dose etoposide after short-term infusion (1992)
    Springer
    Cancer chemotherapy and pharmacology 29 (1992), S. 316-320 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics of high-dose etoposide (total dose, 2100 mg/m2 divided into three doses given as 30-min infusions on 3 consecutive days) were studied in ten patients receiving high-dose combination chemotherapy followed by autologous bone marrow transplantation. In addition to etoposide, all subjects received 2×60 mg/kg cyclophosphamide and either 6×1,000 mg/m2 cytosine arabinoside (ara-C), 300 mg/m2 carmustine (BCNU), or 1,200 mg/m2 carboplatin. Plasma etoposide concentrations were determined by252Cf plasma desorption mass spectrometry. In all, 27 measurements of kinetics in 10 patients were analyzed. According to graphic analysis, the plasma concentration versus time data for all postinfusion plasma ctoposide values were fitted to a biexponential equation. The mean values for the calculated pharmacokinetic parameters were:t1/2β, 256±38 min; mean residence time (MRT), 346±47 min; AUC, 4,972±629μg min ml−1 (normalized to a dose of 100 mg/m2); volume of distribution at steady state (Vdss), 6.6±1.2l/m2; and clearance (CL), 20.4±2.4 ml min−1 m−2. A comparison of these values with standard-dose etoposide pharmacokinetics revealed that the distribution and elimination processes were not influenced by the dose over the range tested (70–700 mg/m2). Also, the coadministration of carboplatin did not lead to significant pharmacokinetic alterations. Although plasma etoposide concentrations at the time of bone marrow reinfusion (generally at 30 h after the last etoposide infusion) ranged between 0.57 and 2.39 μg/ml, all patients exhibited undelayed hematopoietic reconstitution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685951
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of etoposide: correlation of pharmacokinetic parameters with clinical conditions (1993)
    Springer
    Cancer chemotherapy and pharmacology 31 (1993), S. 350-356 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetic parameters of etoposide were established in 35 patients receiving the drug parenterally within the framework of different polychemotherapy protocols. A total of 62 data for 24-h kinetics were analysed. After sample extraction and high-performance liquid chromatography (HPLC) or thin-layer cromatographic (TLC) separation, etoposide was measured by means of [252Cf]-plasma desorption mass spectrometry (PDMS). This highly specific detection system proved to be very practicable and reproducible. The present study comprised two parts that were absolutely comparable in terms of clinical and pharmacokinetic parameters. In part II of the study, sensitivity was improved by modifying the analytical technique. After the exclusion of patients who had previously been given cisplatin or who exhibited renal impairment and of one patient who showed extremely high levels of alkaline phosphatase, γ-GT and SGPT, the mean values calculated for the pharmacokinetic parameters evaluated were: beta-elimination half-life (t 1/2β), 4.9±1.2 h; mean residence time (MRT), 6.7±1.4 h; area under the concentration-time curve (AUC), 5.43±1.74 mg min ml−1; volume of distribution at steady state (Vdss), 6.8±2.7 l/m2; and clearance (Cl), 18.8±5.3 ml min−1 m−2. The pharmacokinetic parameters were correlated with 12 different demographic or biochemical conditions. Impaired renal function, previous application of cisplatin and the age of patients were found to influence etoposide disposition to a statistically significant extent. We suggest that the dose of etoposide should be reduced in elderly patients and/or in individuals with impaired renal function, especially in those exhibiting general risk factors such as reduced liver function with regard to the polychemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686147
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  • 5
    Electronic Resource
    Electronic Resource
    Granulocyte-macrophage colony-stimulating factor binding sites and oxidative metabolism in human granulocytes (1989)
    Springer
    Annals of hematology 59 (1989), S. 486-492 
    Details
    ISSN: 1432-0584
    Keywords: GM-CSF Receptor ; Granulocytes ; Oxidative metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the interaction between GM-CSF and its receptor on human granulocytes and on several human tumor cell lines. Specific high-affinity binding for GM-CSF was characterized by Scatchard plot analysis. The specific radioactivity of the 125I-labeled derivative of rH. GM-CSF was determined by self-displacement analysis and calculated to be 30 μCi/μg. The maximum concentration of binding sites (B max) in granulocytes was 40 fmol/mg protein (2,200 molecules GM-CSF bound/cell) and the dissociation constant (KD) was 0.42 nM. No binding sites for GM-CSF were found in two lung cancer cell lines, SCLC-16HV and NCI-N417 or in the urinary bladder carcinoma cell line 5637, whereas the promyelocytic leukemia cell line HL60 was positive for GM-CSF binding. Time course experiments showed maximum binding of GM-CSF in granulocytes after an incubation period of 60 min and a decrease in binding after an incubation period of 2 h. In parallel, we found a maximum biological signal when granulocytes were preincubated for 90 min with GM-CSF, and a decrease after an incubation time of 120 min. Preincubation of the cells with rH. GM-CSF induced an enhancement of the production of activated oxygen species by the cells in response to PMA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00329493
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  • 6
    Electronic Resource
    Electronic Resource
    Hematopoietic reconstitution after high-dose chemotherapy and autologous nonfrozen bone marrow rescue (1991)
    Springer
    Annals of hematology 63 (1991), S. 253-258 
    Details
    ISSN: 1432-0584
    Keywords: Autologous bone marrow transplantation ; High-dose chemotherapy ; Acute myeloid leukemia ; Malignant lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kinetics of marrow engraftment were analyzed in 50 patient with acute leukemia (21), malignant lymphoma (15), and solid tumors (14) after high-dose multiagent chemotherapy followed by autologous bone marrow transplantation (ABMT) with nonfrozen bone marrow. Unseparated heparinized whole bone marrow was stored in 10% CPDA1 at 4°C for 72 h, then filtered and reinfused. The median number of nucleated cells reinfused was 1.6×108/kg (range 0.5–3.8×108/kg). All patients had a full hematopoietic reconstitution. Median time to achieve a neutrophil count 〉 500/μl was 20 days (range 12–39) and median time to achieve an unsupported platelet count 〉 20.000/μl was 20 days (range 10–55). The main factor associated with delayed engraftment was the number of prior chemotherapy cycles. We conclude that high-dose chemotherapy with nonfrozen ABMT is a safe procedure, without the requirement for costly cryopreservation facilities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01698374
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  • 7
    Electronic Resource
    Electronic Resource
    Prognostic risk factors in advanced Hodgkin's lymphoma (1988)
    Springer
    Annals of hematology 56 (1988), S. 273-281 
    Details
    ISSN: 1432-0584
    Keywords: Hodgkin's lymphoma ; Clinical trial ; Risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a national multicentre trial in the FRG patients with Hodgkin's lymphoma in stages CS/PS III B/IV were entered into the HD 3 protocol and received induction chemotherapy with 3× (COPP+ABVD). Patients in complete remission (CR) received consolidation therapy by either radiotherapy (20 Gy IF) or chemotherapy (COPP+ABVD). Patients not in CR received salvage therapy (40 Gy in case of persisting nodal disease, else 4× CEVD chemotherapy). Between July 1983 and May 1987 230 untreated patients aged 15 to 60 qualified for this HD 3 protocol. This analysis is based on the first 137 patients evaluable for response. Of these, 86 (63%) achieved CR after induction chemotherapy. Including salvage therapy a total of 104 patients (76%) achieved CR. Univariate and multivariate prognostic risk factor analyses were performed using freedom from treatment failure (FFTF) as endpoint. Sex, age, splenectomy, bone marrow, liver and bone involvement had no prognostic impact nor had stage according to the Ann Arbor classification. In contrast, a pretreatment erythrocyte sedimentation rate (ESR) above 80 mm/h and a serum alkaline phosphatase (AP) above 230 IU/ml appeared as significant risk factors (p〈0.01, relative risk 2.3). The two parameters were not independent. Comparing a group A (ESR ≤ 80 and AP ≤ 230) versus a pooled group B (ESR〉80 and/or AP〉230) increased the difference (p〈0.001, relative risk of 2.8) which was also significant for survival (p〈0.04).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320290
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  • 8
    Electronic Resource
    Electronic Resource
    Karyotype and ultrastructure of a colony stimulating factor (CSF) producing cell line (5637) originated from a carcinoma of the human urinary bladder (1986)
    Springer
    Annals of hematology 53 (1986), S. 89-100 
    Details
    ISSN: 1432-0584
    Keywords: Karyotype ; Bladder carcinoma ; Ultrastructure ; CSF ; Cell line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cell line 5637 which originated from a human urinary bladder carcinoma is known to produce GM-CSF and Multi-CSF ectopically. Determination of cell surface antigens defined by monoclonal antibodies was recently reported [6]. Here we report on the ultrastructure and karyology of this CSF secreting cell line. At the ultrastructural level the monolayer in vitro culture and the solid tumors formed in nude mice showed all characteristics consistent with a well-differentiated transitional cell carcinoma (TCC). A subclone was found to grow in suspension and did not secrete any CSF activity. High resolution chromsome analysis revealed chromosomal abnormalities which agreed only in few particulars with nonrandom chromosomal aberrations usually found in TCC. Analysis of the cytogenetic results showed that nearly all structural abnormalities present are known to be associated with acute or chronic human leukemia. The possibility that the ectopic production of CSF in this cell line may be correlated to one or more of the described chromosomal aberrations is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00321091
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  • 9
    Electronic Resource
    Electronic Resource
    GM-CSF Versus G-CSF in the treatment of infectious complication in Felty's syndrome — a case report (1992)
    Springer
    Annals of hematology 64 (1992), S. 205-206 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696225
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  • 10
    Electronic Resource
    Electronic Resource
    Successful treatment of osteoporosis in systemic mastocytosis with interferon alpha-2b (1996)
    Springer
    Annals of hematology 72 (1996), S. 41-43 
    Details
    ISSN: 1432-0584
    Keywords: Key words Systemic mastocytosis ; Osteoporosis ; Alpha-interferon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Osteoporosis is frequently seen in systemic mastocytosis. Although diphosphonate therapy has been shown to be transiently effective, therapy options for this form of osteopenia are very limited. We have treated three patients with systemic mastocytosis and osteopenia successfully with interferon alpha-2b. Two patients had urticaria pigmentosa and two severe back pain due to vertebral compression fractures. All patients received a daily interferon dose of 3×5 mio units/week s.c. for a period of 6 months. Therapy was well tolerated, and back pain resolved in both patients. A marked decrease of mast cell numbers in the bone marrow and a significant increase of bone mineralization and bone density was observed in all patients. Our data suggest that alpha interferon may be a new treatment option for osteopenia in systemic mastocytosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00663015
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