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  • 1
    Electronic Resource
    Electronic Resource
    Frequency and Clinical Significance of DNA Aneuploidy in Acute Leukemia (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 468 (1986), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb42042.x
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of trisomy 12 in CD34+ progenitor cells in a patient with B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization (1997)
    Springer
    Annals of oncology 8 (1997), S. 55-57 
    Details
    ISSN: 1569-8041
    Keywords: CD34+ progenitor cells ; chronic lymphocytic leukemia ; trisomy 12
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract B-cell chronic lymphocytic leukemia (B-CLL) is a slowly progressivedisease resulting from the clonal expansion of mature B lymphocytes. Themost frequent chromosomal abnormality is trisomy 12. Recently moreaggressive therapeutic approaches using myeloablative therapy and autologousstem-cell support have been developed. Phase I/II studies have resulted inmolecular remission and prolonged survival. One cause of relapse may betumor-cell contamination of the transplant. We asked whetherimmunophenotypically identified hematopoietic progenitor cells are part ofthe malignant cell population in B-CLL. In a patient with trisomy 12, twosubpopulations of hematopoietic progenitor cells, CD34+/CD38+ andCD34+/CD38− cells, were isolated byfluorescence-activated-cell-sorting; the sort purity was 98%. Trisomy12 was detected in 13% of CD34+/38+ cells and in 34% ofCD34+/38− cells. These data suggest that CD34+ cells are involved inthe malignant clone of patients with B-CLL. The results are of significancefor future strategies using autologous stem-cell transfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008222015137
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  • 3
    Electronic Resource
    Electronic Resource
    Treatment of advanced chronic lymphocytic leukemia by fludarabine (1991)
    Springer
    Annals of hematology 63 (1991), S. 1-4 
    Details
    ISSN: 1432-0584
    Keywords: Chronic lymphocytic leukemia ; Fludarabine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a clinical phase-II study fludarabine phosphate was given to 20 patients with advanced chronic lymphocytic leukemia who had failed on prior conventional therapy. Fludarabine was administered at a dose of 25 mg/m2/d for 5 days. Treatment cycles were repeated every 4 weeks until maximal response, followed by two cycles for consolidation. Four of the 20 patients achieved complete remission and seven patients partial remission, resulting in an overall response rate of 55% (11/20). Fludarabine therapy was well tolerated, with mild myelosuppression and secondary infections comprising the predominant side effects. These data warrant further confirmation and a randomized comparison of fludarabine with established regimens, which is currently underway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01714952
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  • 4
    Electronic Resource
    Electronic Resource
    Translocation (14; 18) and (8; 22) in three patients with acute leukemia/lymphoma following centrocytic/centroblastic non-Hodgkin's lymphoma (1991)
    Springer
    Annals of hematology 63 (1991), S. 282-287 
    Details
    ISSN: 1432-0584
    Keywords: Translocation (14,18) and (8,22) ; Leukemia ; NHL
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three patients with centrocytic/centroblastic lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01698379
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  • 5
    Electronic Resource
    Electronic Resource
    Cytogenetic findings in 179 patients with myelodysplastic syndromes (1995)
    Springer
    Annals of hematology 70 (1995), S. 171-187 
    Details
    ISSN: 1432-0584
    Keywords: Key words Myelodysplastic syndromes ; Cytogenetic studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cytogenetic analyses were performed on 266 bone marrow and peripheral blood samples from 179 patients with myelodysplastic syndromes (MDS). According to the FAB classification, 42 patients presented with RA, 18 with RARS, 37 with RAEB, 22 with CMML, and 29 with RAEB-T. Nine patients showed a secondary MDS (S MDS). FAB classification was not available for 22 patients. Clonal karyotype anomalies were found in 92 patients (51.4%). Complex chromosome abnormalities occurred in 17 (18.5%) of them. An evolution of the karyotype was detected in 16 cases (17.4%). Cytogenetically independent cells or cell clones were found in eight patients. Nonclonal chromosome abnormalities were uncovered in 29 (16.2%) of the 179 MDS patients. Consecutive studies were performed in 48 patients and revealed a good correlation of initial karyotype and clinical course. The most frequent single anomalies were 5q- in 29 (31.5%), –7 in 22 (23.9%), trisomy 1q in 14 (15.2%), and +8 in 13 (14.1%) of 92 patients respectively. Our cytogenetic findings are presented in detail and discussed in relation to patients' age, morphological classification, clinical course, and prognostic impact. The contribution of cytogenetic findings to the delineation of multistep pathogenesis of MDS with special emphasis to karyotype instability is demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01700373
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  • 6
    Electronic Resource
    Electronic Resource
    Paraneoplastic hypokalemia in acute myeloid leukemia: a case of renin activity in AML blast cells (1996)
    Springer
    Annals of hematology 73 (1996), S. 139-141 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute myeloid leukemia ; Hypokalemia ; Renin ; Aldosteronism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Hypokalemia due to renal potassium loss has frequently been observed in patients with acute myeloid leukemia (AML). The pathogenic mechanism for this hyperkaluresis is unclear. In this report we describe a patient with AML FAB M4, in whom the clinical course, the electrolyte disturbances, the serum aldosterone levels, and the diffuse hyperplasia of the adrenal cortex documented a typical case of marked secondary hyperaldosteronism. On analysis of the leukemic cells of this patient compared with normal bone marrow cells, a significant increase of renin-like activity in the cytosol of the blast cells was noted. Activation of the renin-angiotensin-aldosterone system by paraneoplastic production of renin-like activity in AML blast cells might contribute to the hypokalemia often observed in patients with acute myeloid leukemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050215
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  • 7
    Electronic Resource
    Electronic Resource
    S-HAM induction chemotherapy with or without GM-CSF in patients with high-risk myelodysplastic syndromes (1997)
    Springer
    Annals of hematology 74 (1997), S. 205-208 
    Details
    ISSN: 1432-0584
    Keywords: Key words Myelodysplastic syndromes ; High-dose cytosine arabinoside ; GM-CSF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Thirty-one adult patients with high-risk myelodysplastic syndromes (MDS) were enrolled in a prospective randomized double-blind placebo-controlled trial evaluating the efficacy of sequential high-dose Ara C/mitoxantrone chemotherapy with or without GM-CSF. GM-CSF or placebo was given subcutaneously once daily at a dose of 250 μg/m2 starting 48 h prior to chemotherapy and continued until neutrophil recovery. This design allowed us to investigate the role of GM-CSF as a priming factor for the leukemic clone, as well as its effect on the recovery of normal hematopoiesis. Twenty-eight patients are currently evaluable for response. Ten patients reached a complete remission (36%), eight patients had persistent MDS (29%), and ten patients died within 6 weeks after the onset of treatment (early death). Infectious complications during cytopenia were the major cause of death (8/10). Median time to complete hematologic recovery (neutrophils 〉500/μl and platelets 20 000/μl) and time to neutrophil recovery above 1500/μl was 29 and 35 days, respectively. Median remission duration was 190 days (6.4 months). Analysis of prognostic subgroups showed a low CR rate (25%) and a high early-death rate (44%) in patients 〉55 years of age, suggesting that the intensified treatment approach should be limited to younger patients. No data concerning the influence of GM-CSF on response to chemotherapy or duration of neutropenia are presently available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050285
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  • 8
    Electronic Resource
    Electronic Resource
    Induction of a hematological and cytogenetic remission in a patient with a myelodysplastic syndrome secondary to Fanconi's anemia employing the S-HAM regimen (1997)
    Springer
    Annals of hematology 74 (1997), S. 275-277 
    Details
    ISSN: 1432-0584
    Keywords: Key words Fanconi's anemia ; Myelodysplasia ; High-dose cytosine arabinoside
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report on a patient with Fanconi's anemia (FA) who developed a myelodysplastic syndrome (RAEB-T) with complex karyotypic abnormalities (trp 1q23 q 42, monosomy 20, trisomy 13) at the age of 28. The patient achieved a complete hematological and cytogenetic remission after treatment with sequential high-dose cytosine arabinoside/mitoxantrone followed by G-CSF (5 μg/kg). Bone marrow hypoplasia was prolonged with 38 days of granulocytopenia 〈500/μl and 62 days of platelet transfusion dependency. Nonhematological toxicity did not exceed that of patients without underlying FA. Remission duration was 7 months. This observation shows the feasibility of high-dose Ara C treatment in patients with FA and MDS. Although hematopoiesis remained clonal in remission, the suppression of the cytogenetically abnormal clones transiently reversed the antecedent long-lasting pancytopenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050299
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  • 9
    Electronic Resource
    Electronic Resource
    Mucocutaneous autoimmune syndrome following fludarabine therapy for low-grade non-Hodgkin's lymphoma of B-cell type (B-NHL) (1997)
    Springer
    Annals of hematology 75 (1997), S. 227-230 
    Details
    ISSN: 1432-0584
    Keywords: Key words Fludarabine ; Autoimmune side effects ; Lymphoma ; T cell ; Pemphigus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A 40-year-old patient with low-grade B-NHL developed a generalized macular-papular rash following the first cycle of fludarabine treatment which progressed to a complete epidermal necrolysis following the second cycle. Clinical symptoms and the results of the direct and indirect immunofluorescence were consistent with a mucocutaneous autoimmune syndrome (pemphigus). Immunohistochemical analysis demonstrated a dense epidermal infiltration of CD8+ lymphocytes associated with the histological features of single-cell necrosis of keratinocytes. Early and aggressive immunosuppressive treatment with steroids, cyclophosphamide, and high-dose immunoglobulins resulted in regression of symptoms and complete reconstitution of epidermal integrity. The malignant lymphoma has completely regressed. The findings suggest a fludarabine-induced defect in immunosurveillance – resulting in the uncontrolled activation of autoaggressive T-cell clones – as a pathogenetic mechanism of this life-threatening dermatological complication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050347
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  • 10
    Electronic Resource
    Electronic Resource
    Cytogenetic findings in 179 patients with myelodysplastic syndromes (1995)
    Springer
    Annals of hematology 70 (1995), S. 171-187 
    Details
    ISSN: 1432-0584
    Keywords: Myelodysplastic syndromes ; Cytogenetic studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cytogenetic analyses were performed on 266 bone marrow and peripheral blood samples from 179 patients with myelodysplastic syndromes (MDS). According to the FAB classification, 42 patients presented with RA, 18 with RARS, 37 with RAEB, 22 with CMML, and 29 with RAEB-T. Nine patients showed a secondary MDS (S MDS). FAB classification was not available for 22 patients. Clonal karyotype anomalies were found in 92 patients (51.4%). Complex chromosome abnormalities occurred in 17 (18.5%) of them. An evolution of the karyotype was detected in 16 cases (17.4%). Cytogenetically independent cells or cell clones were found in eight patients. Nonclonal chromosome abnormalities were uncovered in 29 (16.2%) of the 179 MDS patients. Consecutive studies were performed in 48 patients and revealed a good correlation of initial karyotype and clinical course. The most frequent single anomalies were 5q- in 29 (31.5%), −7 in 22 (23.9%), trisomy 1q in 14 (15.2%), and +8 in 13 (14.1%) of 92 patients respectively. Our cytogenetic findings are presented in detail and discussed in relation to patients' age, morphological classification, clinical course, and prognostic impact. The contribution of cytogenetic findings to the delineation of multistep pathogenesis of MDS with special emphasis to karyotype instability is demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01700373
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