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  • 1
    Electronic Resource
    Electronic Resource
    Effect of cyclophosphamide on lymphokine production in MRL/lpr.Yaa mice (1995)
    Springer
    Inflammation research 44 (1995), S. 491-498 
    Details
    ISSN: 1420-908X
    Keywords: MRL/lpr.Yaa mice ; Autoimmune disease ; Lymphokine ; Cyclophosphamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Y chromosome (Yaa gene) from autoimmune BXSB mice has been shown to be responsible for the acceleration of autoimmune symptoms when transferred to MRL/lpr mice. We examined the pathological, serological and immunological characteristics of MRL/lpr.Yaa mice and the suppressive effect of cyclophosphamide (CP) on the mice. MRL/lpr.Yaa mice spontaneously developed a massive lymphadenopathy characterized by hypergammaglobulinemia, the presence of several autoantibodies, and autoimmune disease. In MRL/lpr.Yaa mice, IL-2, IL-4 and IL-5 production in concanavalin A (Con A)-stimulated splenocytes were about 10-fold lower than in BALB/c mice at 5 weeks of age.The concentrations of these lymphokines remained low until the mice were 16 weeks of age. The production of IFN-γ and IL-6 in 16 week old MRL/lpr.Yaa mice was about 4- and 2-fold lower, respectively, though these levels were similar in both strains at 8 weeks of age. It was found that this dysregulation of T cell function was almost identical to that in MRL/lpr mice. Administration of CP to MRL/lpr.Yaa mice ameliorated nephritis, and suppressed production of autoantibodies and the accumulation of abnormal T cells. CP also significantly elevated the production of lymphokines. These findings suggest that an abnormality of T cell function may contribute to the autoimmune pathogenesis of MRL/lpr.Yaa mice and that CP probably ameliorates autoimmune disease by improving the T cell functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01837916
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  • 2
    Electronic Resource
    Electronic Resource
    TNF-α participates in an IgE-mediated cutaneous reaction in mast cell deficient, WBB6F1-W/Wv mice (1996)
    Springer
    Inflammation research 45 (1996), S. 136-140 
    Details
    ISSN: 1420-908X
    Keywords: Allergic cutaneous reaction ; IgE ; TNF-α ; Glucocorticoid ; WBB6F1-W/Wv mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The participation of tumor necrosis factor-α (TNF-α) in a IgE-mediated cutaneous reaction in WBB6F1-W/Wv (W/Wv), mast cell deficient, mice and the effect of prednisolone on this cutaneous reaction were investigated. Mice were passively sensitized by an intravenous injection of monoclonal anti-dinitrophenol (DNP) IgE, and their ears challenged epicutaneously with dinitrofluorobenzene 24 h later. The cutaneous reaction estimated by ear thickness reached a peak 48–72h after the antigen challenge. A monoclonal anti-tumor necrosis factor (TNF)-α antibody inhibited the IgE-mediated cutaneous reaction. An increase of TNF-α mRNA was demonstrated 4h after the application of antigen by the reverse transcriptase-polymerase chain reaction. The injection of recombinant murine TNF-α induced a cutaneous reaction which peaked at 24 h in nonsensitized mice. Prednisolone at doses of 3 to 10 mg/kg clearly inhibited the IgE-mediated cutaneous reaction, however, it did not affect the expression of TNF-α-mRNA. Prednisolone at doses of 1 to 10 mg/kg clearly inhibited the TNF-α-induced cutaneous reaction. These results suggest that TNF-α plays a role in the IgE-mediated cutaneous reaction in W/Wv mice and that prednisolone inhibits the cutaneous reaction at least in part by inhibiting the action of TNF-α.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265167
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of purification-associated reduction in IgE-dependent histamine release from rat peritoneal mast cells (1995)
    Springer
    Inflammation research 44 (1995), S. 541-547 
    Details
    ISSN: 1420-908X
    Keywords: Rat peritoneal mast cell ; Rat peritoneal non-mast cell ; IgE ; Histamine release ; Regulation of histamine release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histamine release from purified rat peritoneal mast cells (PMC) was examined and compared to that from a non-purified preparation (PEC). Both PEC and PMC released similar amounts of histamine upon stimulation with compound 48/80, calcium ionophore A23187 and substance P. In contrast, IgE-dependent histamine release from PMC caused by antigen, anti-IgE and concanavalin A was very low compared to that of PEC. The reduced IgE-dependent histamine release from PMC, however, was recovered when PMC was reconstituted with non-mast cells (NMC) present in the peritoneal cavity. The effect was time-dependent and reached a plateau in 30 min. NMC from both sensitized and non-sensitized rats recovered the reduced histamine release from PMC dose-dependently. The potentiating effect of NMC was observed even in the presence of excess amount of phosphatidylserine. Supernatants of NMC and a mixture of PMC and NMC incubated for 1 hr at 37°C, however, failed to potentiate the histamine release. These results demonstrate that IgE-dependent histamine release from rat peritoneal mast cells is upregulated by other cells present in the peritoneal cavity, and that the mechanism involved is distinct from that of phosphatidylserine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01757359
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  • 4
    Electronic Resource
    Electronic Resource
    The effects of mesoporphyrin on experimental arthritis in mice (1996)
    Springer
    Inflammation research 45 (1996), S. 293-298 
    Details
    ISSN: 1420-908X
    Keywords: Mesoporphyrin ; T cell ; Collagen-induced arthritis ; Superantigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of mesoporphyrin, a novel porphyrin derivative, on type II collagen-induced arthritis in mice were studied. Mesoporphyrin (10–30 mg/kg) and prednisolone (5 mg/kg; reference drug) reduced the incidence and severity of type II collagen-induced arthritis in mice, as assayed by clinical observation and histopathological studies. Although both agents inhibited type II collagen-induced delayed type hypersensitivity in arthritic mice, only prednisolone inhibited humoral immunity to type II collagen. The effects of mesoporphyrin on T cell dependent allergic inflammation were examined, in order to study the mechanism by which it inhibits arthritis. Staphylococcal enterotoxin B (SEB; superantigen)-potentiated collagen-induced arthritis and sheep red blood cell-induced delayed type hypersensitivity reaction were clearly inhibited by mesoporphyrin. Moreover, the superantigen-induced CD-25 expression on T cells was inhibited by mesoporphyrin. These results indicate that mesoporphyrin inhibits type II collagen-induced arthritis by inhibiting the activation of T cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02280994
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  • 5
    Electronic Resource
    Electronic Resource
    Changes in intracranial pressure (ICP) pulse wave following hydrocephalus (1986)
    Springer
    Acta neurochirurgica 82 (1986), S. 50-56 
    Details
    ISSN: 0942-0940
    Keywords: Pulse pressure ; intracranial pressure pulse wave ; elastance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pulse pressure (PP) of the intracranial pressure pulse wave (ICPPW) was measured in experimental and clinical hydrocephalus: namely, obstructive and kaolin-induced hydrocephalus as an experimental study, and noncommunicating and communicating hydrocephalus as a clinical study. At approximately the same ICP level, the PP was much higher in the obstructive hydrocephalus group and slightly higher in the kaolin-induced hydrocephalus group than in the controls. Also the PP level in noncommunicating hydrocephalus patients [3.19mm Hg (SD: 1.04)] was significantly (P〈0.05) higher than that in the communicating hydrocephalus patients [1.88 mm Hg (SD: 0.60)]. The results of our research suggest that the stronger the disturbance of the communication of the CSF between cranial cavity and spinal cavity the higher the PP of ICPPW. This results from the distensibility of the spinal dural sac and exerts a great influence on the elasticity and the PP of the cranial system. It is reasonable, therefore, to suggest that a marked increase in the ratio of the PP to the ICP in the normal or slightly high ICP hydrocephalus may indicate disturbance of the CSF flow, especially loss of CSF communication between the cranial and spinal compartments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01456319
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  • 6
    Electronic Resource
    Electronic Resource
    Prognosis of intracranial germ cell tumours: Effectiveness of chemotherapy with cisplatin and etoposide (CDDP and VP-16) (1993)
    Springer
    Acta neurochirurgica 120 (1993), S. 111-117 
    Details
    ISSN: 0942-0940
    Keywords: Germ cell tumour ; chemotherapy ; CDDP ; VP-16
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A co-operative study for patients with intracranial germ cell tumours was performed to analyze their prognosis and the effectiveness of Cisplatin/Etoposide (CDDP/VP-16) chemotherapy. A total of 46 patients; 30 primary and 16 recurrent cases were registered from 15 participating neurosurgical institutions in Japan. Based on histological criteria and tumour markers, they were classified into three groups; germinoma, germinoma with syncytiotro-phoblastic giant cell (STGC), and non-germinomatous malignant tumour. Sixteen patients were treated with CDDP/VP-16 chemotherapy alone and the other 30 patients were treated by a combination of surgery and/or radiation in addition to chemotherapy. Eleven out of 13 patients (85%) with germinoma showed a complete (n=10) or partial (n=1) response to CDDP/VP-16 chemotherapy even if their tumours were recurrent and there was evidence of CSF dissemination. For the germinoma with STGC and non-germinomatous malignant tumour, a high response rate; 100% for the former and 78% for the latter, could also be achieved in both the primary and the recurrent cases except in those cases of immature teratoma. Their survival times were still different between them. Two-year survival was 50% in germinoma with STGC and 48% in non-germinoma, while it was 88% in germinoma cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02112027
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  • 7
    Electronic Resource
    Electronic Resource
    Measurement of regional cerebral blood flow with H2 15O positron emission tomography during matas test (1995)
    Springer
    Acta neurochirurgica 135 (1995), S. 70-77 
    Details
    ISSN: 0942-0940
    Keywords: H2 15O PET ; Matas test ; cerebral blood flow ; carotid stump pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors carried out a Matas test with a regional cerebral blood flow (rCBF) study using H2 15O positron emission tomography (PET) for three cases of large internal carotid artery aneurysms. There is a likely correlation between the cerebral blood flow (CBF) reduction rate obtained by PET, and the mean stump pressure available from a conventional balloon occlusion test. The advantages of this noninvasive and quantitative method are presented in comparison with other methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02307417
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  • 8
    Electronic Resource
    Electronic Resource
    Studies on poly(adenosine diphosphate-ribose) - XI. Purification of poly(adenosine diphosphate-ribose) on a hydroxylapatite column
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 147 (1971), S. 660-665 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(71)90425-5
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  • 9
    Electronic Resource
    Electronic Resource
    Two-Dimensional Gel Electrophoretograms of Human Chromosome Specific Restriction DNA Fragments
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 196 (1993), S. 1566-1572 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/bbrc.1993.2430
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  • 10
    Electronic Resource
    Electronic Resource
    Effective pinning centers for flux lines in oxide superconductors with YBCO structure
    Amsterdam : Elsevier
    Physica C: Superconductivity and its applications 222 (1994), S. 317-323 
    Details
    ISSN: 0921-4534
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4534(94)90549-5
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