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  • 1
    ISSN: 1432-1084
    Keywords: Key words: Breast radiography ; Technology ; Breast neoplasms ; calcification ; Radiation dose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of our study was to evaluate a mammography unit capable of magnification of up to fourfold at an equivalent or lower dose than with current systems. A prototype mammography tube with an electron-beam-focusing technology resulting in a focal spot size of 40–120 μm was combined with a highly intensifying screen-film system. To evaluate contrast-detail resolution, phantom radiographs were performed with the prototype magnification mammography system using a magnification factor of 1.7 for survey views and a magnification factor of 4.0 for spot views. They were compared with unmagnified survey views and magnification spot views (magnification factor 1.9) of a state-of-the-art mammography system. The radiation exposure was measured and mean glandular doses were calculated. The contrast-detail resolution with both prototype (m = 1.7) and conventional (m = 1.1) survey views was equivalent while the entrance dose and the mean glandular dose were approximately 50 % lower with the prototype. For spot views, the contrast-detail resolution was substantially higher for the prototype than for conventional magnification while the dose was equivalent. Dose reduction and improved detail resolution are possible with this new technology.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1084
    Keywords: Key words: Carcinoma of the breast ; MR imaging ; Prognostic factors ; Histopathology ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The objective of this study was to evaluate the prognostic value of contrast-enhanced MR mammography in patients with breast cancer. A total of 190 patients with breast cancer (37 noninvasive carcinomas, 153 invasive carcinomas) underwent dynamic contrast-enhanced MR mammography preoperatively. Using 1.5-T unit, T1-weighted sequences (2D FLASH) were obtained repeatedly one time before and five times after IV administration of 0.1 mmol gadopentetate-dimeglumine per kilogram body weight. The findings on MR imaging were correlated with histopathologically defined prognostic factors (histological type, tumor size, tumor grading, metastasis in lymph nodes). In addition, immunohistochemically defined prognostic factors (c-erbB-1,c-erbB-2, p53, Ki-67) were correlated with the signal increase on MR mammogram in 40 patients. There was no significant correlation between the findings on MR mammography and the histopathological type of carcinoma, the grading, and the lymphonodular status. Noninvasive carcinomas showed a higher rate of moderate (38 %) or low (27 %) enhancement on MR imaging than invasive carcinomas (6 and 3 %). The results on MR mammography and the results of immunohistochemical stainings did not correlate significantly. Noninvasive carcinomas showed significantly lower enhancement than invasive carcinomas. However, the signal behavior of contrast-enhanced MR mammography is not related to established histopathological prognostic parameters as subtyping, grading, nodal status, and the expression of certain oncogenes/tumor suppressor genes.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 6 (1996), S. 929-931 
    ISSN: 1432-1084
    Keywords: MR imaging ; Mammography ; Breast cancer ; Tumor vascularization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report an unusual case of an invasive breast carcinoma massed by contrast enhanced MR mammography due to rare pathological tumor vascularization.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 9 (1999), S. 1625-1628 
    ISSN: 1432-1084
    Keywords: Key words: Clear-cell chondrosarcoma ; Larynx ; Computed tomography ; Inner surface image ; Surface-rendering image
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A case of a large low-grade mixed clear-cell and conventional chondrosarcoma of the larynx is reported involving the paraglottic space, the cricoid and thyroid cartilage and characterized by an unusual long clinical course over 22 years, although multiple recurrences occurred without developing metastases. Computed tomography suggests diagnosis by detecting calcifications and adequately demonstrates the extension of the tumor. Innersurface and surface-rendering images document the airway stenosis in all directions. The unusual feature of this case consists in the peculiar histopathological differentiation of the observed chondrosarcoma showing a large clear-cell component.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1084
    Keywords: Iotrolan ; CT ; MR ; Arthrography ; Gd-DTPA ; Gleuchumeral joint
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of conventional arthrography versus computed tomography (CT) arthrography of the glenohumeral joint using iotrolan was evaluated in patients with different shoulder problems. In addition, a diagnostic combination of conventional and CT arthrography was compared with magnetic resonance (MR) arthrography of the glenohumeral joint. Two diagnostic protocols were used. Protocol 1: conventional followed after 30 min by CT arthrography of 37 joints using a double contrast technique with iotrolan 300. Protocol 2: conventional followed after 90–180 min by MR arthrography in 20 patients using a single-contrast technique with 10 ml iotrolan 300 and 1 ml gedopentetate dimeglumine 500 mM. Ten patients also underwent CT arthrography. Neither patient group experienced contrast-related complications. Image quality was good for all conventional arthrograms, excellent in 45/47 CT arthrograms and good in 20 MR arthrograms. CT and MR arthrography were diagnostically valuable in many patients. We conclude that glenohumeral joint evaluation should be perfomed first using conventional or CT arthrography. Iotrolan has proven to be highly reliable and safe in these applications. Iotrolan in combination with gadopentetate dimeglumine, permits MR arthrography following completion of the standard examinations if necessary.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1084
    Keywords: Key words: Breast neoplasms ; Breast MR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The objective of this study was to assess the value of contrast-enhanced dynamic breast imaging in patients with carcinoma of unknown primary (CUP). Fourteen patients presenting with metastatic disease compatible with breast cancer (axillary lymph node metastasis: n = 6; supraclavicular lymph node metastasis: n = 1; bone metastasis: n = 3; liver metastasis: n = 3; lung metastasis: n = 1), who had no evidence of tumor in X-ray mammograms and ultrasound, underwent bilateral dynamic breast MR imaging. Suspicious lesions were localized preoperatively using a stereotactic device for MR-guided localization procedures. Magnetic resonance imaging revealed suspicious lesions in 9 of 14 patients. Histopathology revealed invasive carcinoma of the breast in 6 of these patients. Two enhancing lesions were fibroadenomas; one proved to be sclerosing adenosis. In 5 patients MR imaging showed no abnormality. Follow-ups performed up to 1 year after initial treatment revealed no breast cancers in these 5 patients. In patients with metastatic disease of unknown primary, MRI of the breast depicts the primary in a considerable number of cases with normal conventional evaluation.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Der Radiologe 37 (1997), S. 692-701 
    ISSN: 1432-2102
    Keywords: Key words Carcinoma of breast • Contrast-enhanced MR imaging of breast • MR imaging-guided intervention • Preoperative localization • Percutaneous biopsy • MR imaging-compatible needle equipment ; Schlüsselwörter Mammakarzinom • Dynamische MR Mammographie • MRT-gestützte Intervention • Pröoperative Lokalisation • Perkutane Biopsie • MRT-kompatible Punktionsmaterialien
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Suspekte Herdbefunde in der dynamischen MR Mammographie, die mit anderen bildgebenden Verfahren nicht darstellbar sind, könnnen durch MRT-gestützte Interventionen weitergehend bioptisch abgeklärt oder präoperativ markiert werden. Die vorliegende Arbeit gibt einen Überblick über die Möglichkeiten sowie Vor- und Nachteile der von verschiedenen Arbeitsgruppen verwendeten Punktionsvorrichtungen. Weiterhin wird die Palette der derzeit zur Verügung stehenden Punktions- und Markierungsmaterialien präsentiert. Hinsichtlich der suszeptibilitätsbedingten Signalveränderungen kommen hierbei insbesondere der Nadelangulierung und der Sequenzwahl eine entscheidende Bedeutung zu. Zusätzlich zur Illustration repräsentativer Kasuistiken wird das Procedere bei speziellen Problemfällen (Multizentrischer Tumornachweis, bilateraler Tumornachweis) diskutiert. Hinsichtlich der Dokumentation der kompletten Herdentfernung nach MRT-gestützter präoperativer Markierung hat sich die Kontrolluntersuchung innerhalb der ersten postoperativen Woche als sinnvoll erwiesen. In der eigenen Abteilung wurden bisher 174 MRT-gestützte Interventionen durchgeführt. Hierbei ergaben sich bei 36 perkutanen Biopsien zytologisch bzw. histologisch in 67 % der Fälle gutartige und in 25 % der Fälle bösartige Veränderungen. Bei 3 Patienten war das Biopsat insuffizient. Bei 136 MRT-gestützten präoperativen Lokalisationen ergab die histologische Aufarbeitung des Präparates in 51 % einen benignen und in 49 % einen malignen Befund. In 3 Fällen wurde die suspekte Läsion durch den Chirurgen primär nicht entfernt. MRT-gestützte Interventionen der Mamma werden an der Universität Göttingen inzwischen routinemäßig durchgeführt.
    Notes: Summary If suspicious lesions found with MR imaging cannot be visualized by either mammography or ultrasound, MR imaging – based guidance systems are needed to guide needle biopsy or to allow localization of the lesion before surgery. The authors give an overview of the advantages and disadvantages of biopsy devices presented by different working groups. Furthermore, MR-compatible needle equipment for interventions of the breast is demonstrated. The angulation of the needle and the type of sequence are the most important factors for signal loss due to susceptibility. The strategy in special problem cases (multicentricity, bilateral lesions) is discussed. Control MR imaging within the first week after open biopsy is the best way to document the complete excision of a suspicious hypervascularized lesion after MR-guided wire localization. At our institute, percutaneous biopsy (36 interventions) revealed benign findings in 67 % and malignant lesions in 25 % of cases. Three biopsies were insufficient. Histology after MR-guided wire localization (136 interventions) showed benign findings in 51 % and malignancy in 49 % of cases. The suspicious lesion was missed by the surgeion in three cases. We perform MR-guided interventions of the breast routinely in indicated cases.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Mehrschicht-Spiral-CT ; Mehrzeilen-Spiral-CT ; Aortenerkrankungen ; Key words Multi-slice helical CT ; Aortic diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Acute diseases of the central arteries require an immediate investigation. An efficient, fast and reliable diagnosis is necessary because of the high mortality, if the patient remains untreated. These requirements are perfectly fulfilled by the new CT-techniques. Methods. Suspected aortic diseases were examined with a new multi-slice helical CT. The thoracic or the abdominal aorta as well as the entire vascular tree from the supraaortic branches to the inguinal arteries were investigated with different CT protocols. The slice-thickness and the scan mode were changed while the total examination time was kept constant for the first two groups. In the third group a monophasic examination was compared to a biphasic one. Results. In the diagnosis of acute aortic diseases multi-slice helical CT proved to be a fast and reliable method with all scan protocols. The objective measurements of contrast homogeneity and image quality were comparable in the first two groups. The monophasic contrast medium injection protocol was superior to the biphasic administration mode. Conclusions. Multi-slice helical CT appears to be a very effective approach for the diagnosis of acute aortic diseases and seems to be the new gold standard.
    Notes: Zusammenfassung Akute Erkrankungen der Aorta im Körperstamm stellen eine lebensbedrohliche Situation für den betroffenen Patienten dar, so daß ein rasches Handeln zwingend erforderlich ist. Voraussetzung hierfür ist eine leistungsfähige, schnelle und zuverlässige Diagostik, die von der neuen CT-Technik in nahezu idealer Weise realisiert werden kann. Methoden: Bei klinischem Verdacht auf eine Aortenerkrankung wurden Untersuchungen mit einer neuen Mehrzeilen-Spiral-CT (MZ-SCT) durchgeführt. Die Aorta thoracalis, die Aorta abdominalis oder der gesamte Gefäßbaum von den supraaortalen Ästen bis zu den Inguinalarterien wurden mit verschiedenen Protokollen untersucht. In den ersten beiden Gruppen wurden bei konstanter Untersuchungszeit die Schichtdicke und die Tischvorschubgeschwindigkeit variiert. In der dritten Gruppe wurde eine monophasische mit einer biphasischen Untersuchung verglichen. Ergebnisse: In der Diagnostik von aortalen Erkrankungen erwies sich die MZ-SCT als schnelle und verläßliche Methode mit allen Protokollen. Die objektive Messung der Kontrasthomogenität und die subjektiven Abbildungsqualitäten waren in den ersten beiden Gruppen vergleichbar. Das monophasische Vorgehen war der biphasischen Untersuchung überlegen. Schlußfolgerung: Die MZ-SCT ist bei Anwendung geeigneter Untersuchungsprotokolle heute der Goldstandard in der Diagnostik akuter Aortenerkrankungen.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2102
    Keywords: Key words High magnification mammography • Microfocus • Dose reduction • Mammography ; Schlüsselwörter Vergrößerungsmammographie • Mikrofokus • Dosisreduktion • Mammographie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch die technische Realisierung eines Mammographiegerätes mit einem Mikrofokus, das Brennfleckgrößen von 0,12 mm bis 0,05 mm aufweist, kann die direkte Vergrößerungsmammographie in die klinische Routine eingeführt werden. Die technischen Besonderheiten des Gerätes werden vorgestellt. Dosismessungen am Phantom zeigen im Vergleich zu konventionellen Mammographiesystemen bei Übersichtsaufnahmen, die mit 1,7 facher Vergrößerung angefertigt wurden, eine Reduktion um bis zu 50 % bei annähernd vergleichbarer Bildqualität. Bei Zielaufnahmen mit 4 facher Vergrößerung ist ein deutlicher Auflösungsgewinn zu verzeichnen, wobei ähnliche Dosiswerte erreicht werden wie mit konventionellen Systemen. Damit entspricht das neue Mammographiesystem den heutigen Anforderungen im Hinblick auf Ortsauflösung und Strahlenbelastung.
    Notes: Summary A recently developed X-ray unit for mammography using microfocal (spot size 0.12– 0.05 mm) direct magnification radiography will soon be introduced into clinical practice. Unit arrangement and tube construction have been demonstrated. Mean surface dose was measured using PMMA-phantoms. A dose reduction of up to 50 %was obtained in 1.7-fold magnification mammography (full sized views) compared with conventional techniques. The image quality was almost equivalent. However, in comparison with 1,7-fold magnification mammography, a comparable dose range for 4-fold magnifications with the microfocus system was measured with a substantial gain in spatial resolution. These findings satisfy the demands of a modern mammographic unit.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Der Radiologe 36 (1996), S. 951-959 
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Bildgebende Verfahren ; Diagnostik ; Instabilität des Schultergelenks ; Key words Imaging techniques ; Diagnosis ; Shoulder joint instability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The diagnosis of glenohumeral instability is based on the patient's history and physical examination. The main objective in using imaging techniques is to define the tpye and extent of the underlying pathology for therapeutic planning. Plain radiography is the initial step in the diagnostic procedure but can miss typical lesions of the glenohumeral joint structures. CT arthrography and MR imaging offer great sensitivity and accuracy for the detection of traumatic abnormalities of the labral-capsular complex, fractures of the glenoid rim and Hill-Sachs lesions. The advantages and pitfalls of both imaging techniques are discussed.
    Notes: Zusammenfassung Die Diagnose einer glenohumeralen Instabilität wird in den meisten Fällen schon durch die Anamnese und die klinische Symptomatik gestellt. Aufgabe der bildgebenden Verfahren ist es, Art und Ausmaß der zugrundeliegenden Pathologie exakt zu dokumentieren und eine Entscheidungshilfe für das therapeutische Vorgehen zu liefern. Konventionelle Röntgenaufnahmen in gut eingestellten Projektionen stellen unverändert die Grundlage jeder bildgebenden Diagnostik dar, wobei jedoch typische pathologische Befunde insbesondere am Kapsel-Band-Apparat dem radiologischen Nachweis entgehen. Mit der Nativ-CT gelingt der eindeutige Nachweis von knöchernen Verletzungen am Pfannenrand und am Humeruskopf. Als etabliertes Verfahren zur Beurteilung des kapsulolabralen Komplexes gilt die CT-Arthrographie. Nachteile sind die Gelenkpunktion und der vermehrte Zeitaufwand. Als Alternative bietet sich die Magnetresonanztomographie an. Sie liefert als nicht-invasive Untersuchung mit hohem Gewebekontrast in beliebigen Schnittebenen in der Diagnostik des Labrums und der Gelenkkapsel eine ähnlich hohe Treffsicherheit, kann jedoch bei Formvarianten und fehlendem Gelenkerguß diagnostische Schwierigkeiten aufwerfen. Der Stellenwert der verschiedenen Verfahren wird diskutiert.
    Type of Medium: Electronic Resource
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