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  • 1
    Electronic Resource
    Electronic Resource
    A new method of veno-venous bypass during human orthotopic liver transplantation (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 49 (1994), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Veno-venous bypass is commonly used during orthotopic liver transplantation, but there is some controversy as to whether it contributes to a better outcome. Low shunt flows frequently reduce the efficacy of portofemoro-axillary systems and so a percutaneous cannulation technique for the subclavian and femoral vein with large bore catheters was developed in order to facilitate bypass management. This study reports the performance and complications of a portofemoro-subclavian bypass system during the anhepatic phase of human orthotopic liver transplantation in 85 patients. A percutaneous cannulation technique and two 7 mm (subclavian and femoral) catheters, inserted pre-operatively, were used in a pump driven portofemoro-subclavian bypass system. Coagulation profiles, shunt flows, haemodynamic parameters, and peri-operative complications associated with bypass were recorded for each patient. Percutaneous cannulation of the left femoral and subclavian vein was successful in 78 patients (91.8%). Mean femoro-subclavian shunt flow was 1.45 1.min-1 (SD 0.37), and mean portofemoro-subclavian flow was 4.28 1.min-1 (SD 1.03). Although oxygen delivery was not maintained at pre-shunt levels (559.7 (SD 147) vs 506 (SD 107) ml.min-1.m-2, p 〈 0.05) renal perfusion pressure stayed above 50 mmHg (during shunt it was 56 (SD 9) mmHg). One intra-operative air embolism was observed (1.2%), and in one patient a myocardial infarction occurred during the anhepatic phase; neither complication was considered to be related to the percutaneous cannulation technique. There were no bleeding complications. After operation, all chest X rays were normal and clinical examination revealed no adverse effects of portofemoro-subclavian bypass. Percutaneous cannulation for portofemoro-subclavian bypass using 7 mm catheters for the femoral and subclavian vein is a rapid, simple, effective, and safe method for management of adverse haemodynamic effects during the anhepatic phase of orthtopic liver transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1994.tb03471.x
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  • 2
    Electronic Resource
    Electronic Resource
    A rare intra-operative complication in a child with Von Recklinghausen's neurofibromatosis (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 37 (1982), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A case of a boy with neurofibromatosis including unsuspected cerebral involvement and subsequent development of severe neurogenic pulmonary oedema during surgery in the prone position is reported. The importance of careful positioning is emphasised.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1982.tb01815.x
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  • 3
    Electronic Resource
    Electronic Resource
    Immunoelectronmicroscopic examination of early lesions in histamine induced immune complex vasculitis in man (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 99 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In 4 cases of allergic vasculitis circulating immune complexes (IC) were demonstrated. Spontaneous and histamine induced vascular changes were studied by immunofluorescence microscopy. The early events in IC vasculitis were investigated at the ultrastructural level by immunoelectronmicroscopy using the peroxidase-antiperoxidase multistep technique.Our findings support the concept that human IC vasculitis is triggered by the deposition of circulating IC in the walls of postcapillary venules between endothelial cells, pericytes and the layers of the basal lamina. Tissue destruction is only secondary due to local complement activation and the release of lysosomal enzymes from chemotactically attracted leukocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb01955.x
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  • 4
    Electronic Resource
    Electronic Resource
    Untersuchung der Lecithin-Cholesterin-Acyltransferase-Aktivität im Serum von drei Patienten mit Tangier-Krankheit (Hyp-alpha-Lipoproteinämie) (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 1059-1061 
    Details
    ISSN: 1432-1440
    Keywords: Tangier disease ; lecithin-cholesterol-acyltransferase ; cholesterol ester storage ; Tangier-Krankheit ; Lecithin-Cholesterin-Acyltransferase ; Cholesterinesterspeicherung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Enzymaktivität der Lecithin-Cholet sterin-Acyltransferase wurde bei drei Patienten mit Tangiere Krankheit (Hypalphalipoproteinämie) bestimmt. Für den Teswurde3H-markiertes Lecithin als Substrat verwendet. Di-LCAT-Aktivität war bei den drei Patienten auf 50%, 33% bzw. 17% der Enzymaktivität bei gesunden Kontrollpersonen erniedrigt. Die exzessive Cholesterinesterspeicherung in Tonsillen, Lymphknoten, Milz und Leber dieser Patienten kann demnach nicht auf eine gesteigerte Cholesterinesterproduktion im Serum zurückgeführt werden.
    Notes: Summary Lecithin-cholesterol-acyltransferase (LCAT) activity was determined in three patients with Tangier disease using3H-labelled lcithin as substrate. The LCAT enzyme activity in the patients was 50%, 33% and 17% of the enzyme activity in the serum of healthy individuals. Thus cholesterol ester storage in cells of tonsils, lymph nodes, spleen and liver of these patients cannot be caused by increased LCAT enzyme activity in the serum of these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468319
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  • 5
    Electronic Resource
    Electronic Resource
    Der Mechanismus der Blutkörperchensenkung. XVII Über den Zusammenhang und die diagnostische Bedeutung der Lecithin-Cholesterin-Acyltransferase-Aktivität im Humanserum und der Wärmeinaktivierung der Blutkörperchensenkung (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 208-215 
    Details
    ISSN: 1432-1440
    Keywords: Lecithin-cholesterol-acyltransferase ; lysolecithinase ; Erythrocyte sedimentation ; Lecithin-Cholesterin-Acyltransferase (LCAT) ; Lysolecithinase ; Blutkörperchensenkung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Enzymaktivität der Lecithin-Cholesterin-Acyltransferase (LCAT) wurde bei 80 gesunden Männern und Frauen, 13 Schwangeren und bei verschiedenen Patienten mit neoplastischen oder hepatischen Erkrankungen untersucht. Bei dem Test wurden Lipoproteine mit32P-3H-markiertem Sojabohnenlecithin als Substrat verwendet. Es konnten signifikante Einflüsse von Alter, Geschlecht und Krankheit auf die Enzymaktivität beobachtet werden: Die LCAT-Aktivität war bei Männern bis 30 Janre höher als bei Frauen der gleichen Altersstufe, ebenso war sie bei Frauen über 40 Jahre höher als bei jüngeren Frauen. Bei den Schwangeren waren sowohl die LCAT-Aktivität als auch die Lysolecithinase-Aktivität gesteigert. Krankheiten, die die Proteinsynthesekapazität der Leber herabsetzen wie Cirrhose oder fortgeschrittene neoplastische Erkrankungen, gingen mit einer erniedrigten LCAT-Aktivität einher. Die Hemmung einer beschleunigten Blutkörperchensenkung nach Inkubation des Plasmas bei 37° wird durch die Zunahme der Plasmalysolecithinkonzentration bewirkt, die ein Ergebnis der LCAT-Aktivität ist. Die klinische Bedeutung von Unterschieden in der Hemmbarkeit von beschleunigten Blutkörperchensenkungen bei neoplastischen und entzündlichen Erkrankungen wird erörtert. Widersprüchliche Befunde in früheren Untersuchungen zu diesem Thema können durch die beobachteten geschlechts- und altersabhängigen Unterschiede in der LCAT-Aktivität, sowie durch die Einflüsse von Lysolecithinase-Aktivität und Plasmaalbuminkonzentration auf die Senkungshemmung erklärt werden.
    Notes: Summary The activity of the lecithin-cholesterol-acyltransferase (LCAT) was determined in 80 healthy men and women, 13 pregnant women, and various patients mostly with neoplastic or hepatic diseases. Lipoproteins with32P-3H-labelled sojabean-lecithin were used as substrate. Significant influences of age, sex and diseased states could be observed: The enzyme activity was more elevated in young men up to 30 years than in women of the same age, it was also higher in women over 40 years compared to that in younger women. The LCAT activity and the lysolecithinase activity were increased in pregnant women. The LCAT activity was decreased in diseases affecting the protein synthesis capacity of the liver like cirrhosis or advanced cancer. The inhibition of accelerated erythrocyte sedimentation after incubation of plasma at 37° is caused by an increase in plasma lysolecithin concentration due to LCAT activity. The clinical importance of differences in the inhibition of accelerated erythrocyte sedimentation in neoplastic and inflammatory diseases is discussed. Contradictory findings in earlier investigations on this subject can be explained on the basis of the differences observed in LCAT activity due to age and sex, variations in the lysolecithinase-activity, and plasma albumin concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468593
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  • 6
    Electronic Resource
    Electronic Resource
    The specific effect of plasma proteins in erythrocyte sedimentation (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 265-273 
    Details
    ISSN: 1432-1440
    Keywords: Erythrocyte sedimentation rate ; plasma proteins ; correlation coefficient ; myocardial infarction ; Blutkörperchensenkungsgeschwindigkeit ; Plasmaproteine ; Korrelationskoeffizienten ; Herzinfarkt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Bei 72 Probanden, davon 37 Herzinfarktpatienten wurde der Spearmansche Rangkorrelationskoeffizient von BKS-Geschwindigkeit und den Konzentrationen von zwanzig einzelnen Plasmaproteinen bestimmt. Die höchsten Korrelationskoeffizienten wurden in der Reihenfolge ihrer Nennung gefunden für: Fibrinogen, Orosomukoid, α-2-Makroglobulin, α-1-Antitrypsin, Coeruloplasmin, Ig M. Die Summe der molaren Konzentrationen von Fibrinogen, α-2-Makroglobulin und Ig M wies gegenüber der BKS-Geschwindigkeit die engste Korrelation auf. 2. Die Aufschlüsselung des untersuchten Kollektivs nach der Diagnose ergab, daß für viele Plasmaproteine der Grad der Korrelation zur BKS-Geschwindigkeit wesentlich von der Zusammensetzung des untersuchten Patientengutes abhängt. Die Gruppe der Patienten mit Herzinfarkt, mit Pneumonie und mit Neoplasma wiesen jeweils deutlich verschiedene Korrelationsspektren auf, denen offenbar krankheitsspezifische Änderungen der Konzentrationen der Plasmaproteine zugrunde liegen. 3. Bei 4 Herzinfarktpatienten wurden über einen Zeitraum von 26 Tagen die Änderungen der Plasmaproteinkonzentrationen im Zusammenhang mit der BKS-Geschwindigkeit verfolgt.
    Notes: Summary 1. Spearman's rank correlation coefficient between erythrocyte sedimentation rate and the concentration of twenty individual plasma proteins was determined in 72 persons including 37 patients with recent myocardial infarction. The highest correlation coefficients with ESR could be demonstrated in the following proteins: fibrinogen, α-1-acid-glycoprotein, α-2-macroglobulin, α-1-antitrypsin, coeruloplasmin, Ig M. The closest correlation with ESR was found, when the molar concentrations of fibrinogen, α-2-macroglobulin and Ig M were summed up. 2. Subdivision of the examined group of patients according to their diagnosis showed that the degree of correlation with ESR in many plasma proteins essentially depends on the composition of the studied group of patients. The patients with myocardial infarction, with pneumonia and those with neoplasma all showed distinctly different patterns of correlation. These obviously reflect underlying changes in the concentrations of the studied proteins, that seem to be specific to the respective disease. 3. In 4 patients with myocardial infarction the changes in plasma protein concentrations together with ESR were followed over a period of 26 days after the infarction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469118
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  • 7
    Electronic Resource
    Electronic Resource
    Erythrocyte sedimentation rate and C-reactive protein (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 169-171 
    Details
    ISSN: 1432-1440
    Keywords: Blutkörperchensenkungsgeschwindigkeit ; C-reaktives Protein ; Akute-Phase-Proteine ; Methode ; Erythrocyte sedimentation rate ; C-reactive protein ; Acute phase proteins ; Method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary C-reactive protein (CRP) was isolated from pleura exudate of patients with metastasing cancer and added to plasma of healthy blood donors. Only the addition of excessive amounts of CRP (220 mg/ml) caused a notable increase in erythrocyte sedimentation rate. An immunoelectrophoretic method for the simultaneous quantitative determination of CRP together with C 3 or other acute phase reactants is described.
    Notes: Zusammenfassung C-reaktives Protein (CRP) wurde aus dem Pleuraexsudat von Patienten mit metastasierenden Tumoren isoliert und zu dem Plasma von gesunden Blutspendern zugefügt. Nur die Zugabe von extrem hohen Mengen von CRP (220 mg/ml) verursachte eine gewisse Beschleunigung der Erythrozytensenkungsgeschwindigkeit. Außerdem wird eine immunelektrophoretische Methode für die gleichzeitige quantitative Bestimmung von CRP und C 3 oder anderen akute-Phase-Proteinen beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468881
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  • 8
    Electronic Resource
    Electronic Resource
    The human peripheral lymphocyte—a model system for studying the combined effect of psoralen plus black light (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 137-140 
    Details
    ISSN: 1432-1440
    Keywords: Psoralen ; UVA ; Lymphocyt ; Photochemotherapie ; Psoriasis ; Psoralen ; UVA ; Lymphocyte ; Photochemotherapy ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The effect of psoralen plus long wavelength ultraviolet light (UVA) on3H-thymidine uptake of PHA stimulated human lymphocytes was investigated. PHA induced lymphocyte transformation was inhibited by the combined action of psoralen and UVA irradiation in a dose related manner. Inhibition of DNA-synthesis occurred at concentrations of psoralen that can be expected in the serum of patients treated by systemic photochemotherapy. No effect was noted at these psoralen concentrations in the absence of UVA irradiation. Also did UVA irradiation in the absence of psoralen not inhibit3H-thymidine incorporation into PHA stimulated lymphocytes.
    Notes: Zusammenfassung Es wurde die Wirkung von Psoralen zusammen mit langwelligem ultraviolettem Licht (UVA) auf den3H-Thymidin-Einbau PHA-stimulierter humaner Lymphocyten untersucht. Die PHA-induzierte Lymphocytentransformation wurde durch Psoralen plus UVA gehemmt, abhängig sowohl von der Psoralenkonzentration als auch der Einwirkdauer der UVA-Bestrahlung. Die Hemmung der DNA-Synthese in den stimulierten Lymphocyten erfolgte bei Psoralenkonzentrationen wie sie auch im Serum von Patienten erwartet werden können, die sich einer systemischen Photochemotherapie unterziehen. Ohne UVA-Bestrahlung war bei diesen Psoralenkonzentrationen kein Effekt auf die DNA-Synthese nachweisbar. Ebenso erwies sich alleinige UVA-Bestrahlung ohne Psoralenzusatz als wirkungslos auf das Wachstum PHA-stimulierter Lymphocytenkulturen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01490241
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  • 9
    Electronic Resource
    Electronic Resource
    Lecithinabbau und Cholesterinveresterung im Humanserum (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 203-207 
    Details
    ISSN: 1432-1440
    Keywords: Lipoprotein ; lecithin-cholesterol acyltransferase ; hyperlipidaemia ; Lipoprotein ; Lecithin-Cholesterin Acetyl-transferase ; Hyperlipidämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die physiologische Rolle der Lecithin-Cholesterin Acyltransferase (LCAT) scheint im Transport von Cholesterin von den peripheren Geweben einschließlich der Membranen der Blutzellen zur Leber zu liegen. Eine weitere Funktion ist vermutlich die Stabilisierung der Lipoproteinstruktur. Dies geht aus klinischen Befunden bei Patienten hervor, die an einem primären genetischen oder sekundärem LCAT-Mangel leiden. Die LCAT-Aktivität hängt vom funktionellen Zustand der Leber ab, die für die Synthese des Enzyms verantwortlich ist. Die Veresterungsaktivität wird zusätzlich stark von der Menge und der Lipidzusammensetzung des Lipoproteinsubstrates beeinflußt. Aus diesem Grund ist die LCAT-Aktivität bei Hyperlipidämien oft gesteigert.
    Notes: Summary The physiological role of lecithin-cholesterol acyltransferase as is known so far is the transport of cholesterol from peripheral tissues including blood cell membranes to the liver. Another function seems to consist in the stabilization of the lipoprotein structure. This is suggested by clinical findings in patients with either genetic or secondary LCAT-deficiency. LCAT-activity depends on the functional state of the liver which is responsible for the enzyme synthesis. The esterifying activity is also greatly influenced by the quantity and the lipid composition of lipoprotein substrate. Therefore, hyperlipidaemia is often associated with increased LCAT-activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468592
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  • 10
    Electronic Resource
    Electronic Resource
    Comparison of histidine-tryptophan-ketoglutarate (HTK) solution versus University of Wisconsin (UW) solution for organ preservation in human liver transplantation (1994)
    Springer
    Transplant international 7 (1994), S. 177-181 
    Details
    ISSN: 1432-2277
    Keywords: HTK solution ; UW solution, liver preservation ; Liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Over a 30-month period, 60 patients (30 in each group) suffering from end-stage liver disease or primary hepatic malignancy and scheduled for liver transplantation were enrolled in a prospective, randomized study to compare two methods of liver preservation: histidinetryptophan-ketoglutarate (HTK) solution versus University of Wisconsin (UW) solution. Entry criteria for both groups were: age (18–65 years), elective surgery (transplantable or urgent category of the recipients), first transplantations and harvesting procedure performed by the same team. The parameters under investigation were the clinical and laboratory data preand post-transplantation, as well as follow-up data such as complications and survival. There were no significant differences in the two groups as far as the evaluation criteria were concerned, even when cold ischemia time was more than 15h (n=7). A slight, yet not significant, increase in late complications of the biliary anastomoses could be seen in the UW group. Hepatocellular injury (SGOT, SGPT, GLDH, lactate) appeared to be more marked in the HTK group. These results suggest that both HTK and UW solutions are appropriate for clinical use in liver transplantation, even if cold ischemia time is more than 15h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327084
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