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  • 11
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 891-891 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01737015
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  • 12
    Electronic Resource
    Electronic Resource
    Sekundärer Immundefekt bei Niereninsuffizienz am Beispiel der Hepatitis B-Impfung (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 865-872 
    Details
    ISSN: 1432-1440
    Keywords: Hepatitis B-vaccination ; Dialysis patients ; Immune deficiency ; Monocyte function ; Hepatitis B-Impfung ; Dialyse-Patienten ; Sekundärer Immundefekt ; Monozytendefekt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die aktive Hepatitis-B-Impfung führt bei Gesunden in über 95%, bei Dialysepatienten nur in ca. 60% zur Bildung protektiver anti-HBs-Antikörper. In vitro geht der Non-Responder-Status mit einer gestörten Monozytenfunktion einher, die eine mangelhafte Interleukin-2-Produktion nach sich zieht. Gleichzeitig findet sich eine vermehrte Expression funktioneller Interleukin-2-Rezeptoren. Exogen zugeführtes Interleukin-2 normalisiert daher bereits in niedriger Dosierung die vorher verminderte proliferative Antwort von Non-Responder-Lymphozyten in vitro. Außerdem läßt sich der Non-Responder-Status von Dialysepatienten in vivo beheben, wenn zur Standard-Impfung mit 40 µg Hepatitis B-Vakzine zusätzlich eine niedrige Interleukin-2-Dosis (2,5 × 105 Einheiten) lokal appliziert wird.
    Notes: Summary In dialysis patients the immune response to hepatitis B-vaccination is greatly impaired. In vitro the non-responders show a failure of the monocytes to support the process of primary T-cell activation. This defect results in a lack of interleukin 2-production and an enhanced sensitivity of the interleukin-2 receptor system. Addition of low doses of interleukin-2 fully reconstitutes the deficient immune response in vitro. Furthermore, the local application of low dose interleukin-2 during a standard vaccination with 40 µg hepatitis B-vaccine normalizes the non-responder state in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728948
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  • 13
    Electronic Resource
    Electronic Resource
    Acute hepatic failure: limitations of medical treatment and indications for liver transplantation (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 875-881 
    Details
    ISSN: 1432-1440
    Keywords: Acute hepatic failure ; Liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00185596
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  • 14
    Electronic Resource
    Electronic Resource
    Sustained elimination of hepatitis B virus from serum induced in a patient with chronic hepatitis B and advanced human immunodeficiency virus infection (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 1030-1036 
    Details
    ISSN: 1432-1440
    Keywords: Human immunodeficiency virus ; Hepatitis B virus ; Interferon-α ; Corticosteroid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 48-year-old male patient was admitted with acquired immunodeficiency syndrome (stage III, Centers for Disease Control 1993) and viremic hepatitis B. Blood CD4 count was 15/μl. Discontinuation of prednisolone, previously prescribed by the patient's family practitioner because of elevated liver enzymes, resulted in severe hepatitis (alanine aminotransferase 〉 300U/1). Administration of interferon-α, (9 × 106U s.c. 3 × weekly) was initiated. Serum markers of viral replication disappeared, and aminotransferase levels returned to normal within a few weeks. The patient's serum was found negative for HBsAg after 3 months. Immunohistochemical analysis of liver biopsies before and during interferon therapy showed disappearance of all hepatitis B virus antigens and a marked reduction in inflammatory activity. Hepatitis B virus seroconversion remained stable until the patient died from the syndrome 2 years later. This case shows that in spite of severe HIV-associated immune deficiency with CD4 counts constantly below 100/μl, interferon-α can lead to sustained serological and histological improvement of viremic hepatitis B. Previous administration and discontinuation of cortisone may have helped to reach this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577750
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  • 15
    Electronic Resource
    Electronic Resource
    Experimentelle Untersuchungen zur Keratoconjunctivitis photoallergica (1961)
    Springer
    Archives of dermatological research 213 (1961), S. 499-501 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588805
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  • 16
    Electronic Resource
    Electronic Resource
    Angiomyolipome der Nieren bei Morbus Bourneville-Pringle (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 920-924 
    Details
    ISSN: 1432-1440
    Keywords: Angiomyolipoma ; Bourneville's disease ; Tuberous sclerosis ; Renal complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three cases with renal angiomyolipoma in Bourneville's disease are reported. In two patients advanced renal insufficiency developed, one being treated by chronic intermittent hemodialysis. In the third patient rupture of angiomyolipoma with severe retroperitoneal bleeding occurred. In one patient, tumorous enlargement initially was diagnosed only in the right kidney and preceded angiomyolipoma of the left kidney for several years. In this patient nephrectomy was performed because malignancy was assumed before diagnosis of Bourneville's disease was established. Occasionally, histology may suggest sarcomatous changes. However, the absence of distant metastasis and the overall long survival of patients with renal angiomyolipoma in Bourneville's disease underline the benign character of the tumor. Treatment should be conservative because surgical intervention with loss of kidney parenchyma may enhance progression to end-stage renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727443
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  • 17
    Electronic Resource
    Electronic Resource
    A case of sjögren's syndrome with severe anemia due to myelitis (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 92-95 
    Details
    ISSN: 1432-1440
    Keywords: Sjögren's syndrome ; Anemia ; Vasculitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An unusual case of Sjögren's syndrome presenting with severe anemia as the predominant clinical feature is described. Histological examination of a bone marrow biopsy specimen demonstrated that the patient's anemia was caused by myelitis and vasculitis of the small intraosseous vessels. Our report might stimulate a more thorough investigation of bone marrow in patients with connective tissue diseases and anemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784137
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  • 18
    Electronic Resource
    Electronic Resource
    Rare association of herpes simplex virus IgM-specific antibodies and Guillain-Barré syndrome successfully treated with plasma exchange and immunosuppression (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 468-474 
    Details
    ISSN: 1432-1440
    Keywords: Guillain-Barré syndrome (GBS) ; Herpes simplex virus (HSV)-IgM antibodies ; Immunohistology ; Plasma exchange ; Immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Herpes simplex virus (HSV) has been associated with various neurological disorders. In contrast, HSV infection is very rarely found in acute polyneuroradiculitis. In this report, a patient is described with a severe course of Guillain-Barré syndrome (GBS). HSV IgM-specific antibodies and a rise of complement-fixation antibodies were detected. During the acute phase of neurologic syndrome, a nerve biopsy showed myelin damage and IgM deposits on the inner layer of the perineurium. Plasma exchange, in combination with immunosuppression, was successfully applied as a treatment in the relapsing course of GBS. Finally, after recovery, HSV-specific IgM antibodies disappeared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731495
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  • 19
    Electronic Resource
    Electronic Resource
    Chirurgie bei Hepatitis (1998)
    Springer
    Der Chirurg 69 (1998), S. 522-529 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Viral hepatitis ; Liver function ; Liver cirrhosis ; Immunprophylaxis ; Treatment of viral hepatitis. ; Schlüsselwörter: Virushepatitis ; Leberfunktion ; Lebercirrhose ; Immunprophylaxe ; Behandlung der Virushepatitis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Virushepatitiden gehören weltweit zu den wichtigsten Infektionskrankheiten. Allein über 300 Millionen chronische HBsAg-Träger und etwa die gleiche Anzahl chronischer Hepatitis-C-Virusträger werden geschätzt. Nach der Tuberkulose steht die Virushepatitis in der Statistik der infektiös bedingten Berufskrankheiten an zweiter Stelle. Insbesondere Teile Asiens, Afrikas, Lateinamerikas sowie der Mittelmeerraum und der Nahe Osten werden zu den Hochendemiegebieten der Virushepatitis gezählt. Aufgrund der immunologischen und molekularen Differenzierung sind heute die Virushepatitiden von A bis E einschließlich G weitgehend charakterisiert. Während die enteral übertragene Hepatitis A und E nur akute und in seltenen Fällen fulminante Verläufe induzieren, sind die Hepatitis B, ihre Koinfektion und Superinfektion mit Hepatitis Delta und die Hepatitis C insbesondere durch chronische Verläufe von großer medizinischer Bedeutung. Diese Erkrankungen können als Spätfolge in eine Lebercirrhose mit all ihren Komplikationen, einschließlich des primären Leberzellcarcinoms übergehen. Die für die Chirurgie besonderen Aspekte der Virushepatitis sollen diskutiert werden.
    Notes: Summary. Viral hepatitis belongs to the most important infectious diseases worldwide. More than 300 million chronic HBsAg carriers and chronic HCV carriers exist, respectively. High endemic areas of viral hepatitis are Asia, Africa, Latin America and the Near, Middle and Far East. Viral hepatitis is also very important in health care workers. Today viral hepatitis can be differentiated from type A to type E (G) based on immunological and molecular assays. While enterally transmitted hepatitis type A and type E only induce acute and rare fulminant disease, hepatitis type B, C and D often induce chronic progressive disease including liver cirrhosis with typical complications due to the portal hypertension and with a high rate of association with the development of primary liver cancer (HCC). This review focusses on viral hepatitis-related surgical problems, including liver transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050449
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  • 20
    Electronic Resource
    Electronic Resource
    Zur Induktion einer aktiven chronischen Hepatitis durch heterologe lösliche Leberproteine (1968)
    Springer
    Virchows Archiv 345 (1968), S. 365-376 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Untersuchungen gehen von dem früher geführten Nachweis eines im immunologischen Sinne organspezifischen und weitgehend speciesexclusiven Proteins der Leber aus. Entsprechende Proteinpräparationen aus menschlichen Lebern wurden zur Sensibilisierung von Kaninchen eingesetzt. 1. Bei langdauernder Sensibilisierung (über 1 Jahr) mit kleinen Dosen gelang beim erwachsenen Kaninchen die Induktion einer Immuntoleranz, die durch Applikation von hitzeund sulfanilsäurealteriertem Protein durchbrochen werden konnte; gleichzeitig konnte eine Hypersensibilität vom verzögerten Typ induziert werden. Histologisch fand sich bei allen Tieren eine aktive chronische Hepatitis; die übrigen Organe (Herz, Lunge, Skeletmuskulatur, Schilddrüse und Niere) waren frei von pathologischen Veränderungen. 2. Bei kurzzeitiger Sensibilisierung (3 Monate) mit hohen Dosen fand sich histologisch lediglich eine dichtzellige lymphocytäre Infiltration der Periportalfelder der Leber; nur bei einem Tier bestanden geringe Hinweiszeichen auf eine beginnende chronische Lebererkrankung. In der Diskussion wird auf die serologisch nachweisbare Antigenverwandtschaft der entsprechenden Proteine von humaner und Kaninchenleber hingewiesen. Für die Entwicklung einer chronisch-progredienten Organerkrankung scheint die Ausbildung einer Hypersensitivität vom verzögerten Typ im Rahmen einer langdauernden Stimulierung wesentlich zu sein.
    Notes: Summary These investigations are concerned with species- and organspecific liver proteins, demonstrated in earlier studies. Rabbits were sensitized utilizing similar protein-preparations obtained from human liver. 1. With long-term sensitizations (approximately one year) immuntolerances were induced in adult rabbits by chronic administration of small doses of protein. The state of immun tolerance could be disturbed by applying of heat- and sulfanilic acid-altered protein, which at the same time could be shown to have induced hypersensitivity of delayed type. — Histologically active chronic hepatitis was found in all animals. Other organs such as heart, lung, skeletal muscle, thyroid gland and kidney were not affected. 2. In short-term sensitizations with a high dosis of liver protein only dense lymphocytic infiltrations in the periportal areas were found histologically. In one animal only early changes of a chronic hepatitis were seen. Antigenic relations between human and rabbit liver proteins, as demonstrated earlier by serological techniques, are discussed in detail. Hypersensitivity of the delayed type would seem to play an important role in the development of active chronic hepatitis. This condition can be produced with long-term stimulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00586254
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