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  • 11
    Electronic Resource
    Electronic Resource
    Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans (1980)
    Springer
    Diabetologia 18 (1980), S. 209-216 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptors ; acanthosis nigricans ; insulin resistance ; insulin receptor autoantibodies ; Type A patients ; Type B patients ; negative cooperativity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report analyzes the in vitro characteristics of 125I-insulin binding to the monocytes of nine patients with the syndromes of acanthosis nigricans and insulin resistance. The 3 Type A patients (without demonstrable autoantibodies to the insulin receptor) had decreased binding of insulin due to a decreased concentration of receptors. In these patients the residual receptors demonstrated normal dissociation kinetics, negative cooperativity, and were blocked by anti-receptor antibodies in a manner similar to normal cells. In contrast, monocytes from the 6 Type B patients (with circulating anti-receptor autoantibodies) had decreased binding of insulin due to a decrease in receptor affinity. Insulin binding to monocytes of Type B patients demonstrated accelerated rates of dissociation with no evidence of cooperative interactions among insulin receptors. When coupled with previous data, the present studies further suggest that different mechanisms account for the defects in insulin binding and insulin resistance observed in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251918
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  • 12
    Electronic Resource
    Electronic Resource
    Insulin and insulin receptors in rodent brain (1981)
    Springer
    Diabetologia 20 (1981), S. 268-273 
    Details
    ISSN: 1432-0428
    Keywords: Central nervous system ; CNS peptides ; insulin receptors ; insulin ; experimental diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary While insulin effects on the central nervous system (CNS) mediated through hypoglycaemia are well known, direct insulin effects on the CNS remain controversial. Recently, we found insulin receptors in all areas of the rat brain, with highest concentrations in the olfactory bulb, cerebral cortex and hypothalamus; all areas involved in feeding. Insulin receptors in brain were, by multiple criteria, similar to insulin receptors on classical target tissues for insulin, such as liver and fat. Insulin itself has been identified in the rat brain at concentrations on average ten times higher than in plasma. Highest concentrations were found in the olfactory bulb and hypothalamus. Brain insulin was indistinguishable from purified insulin by its behaviour in the radioimmunoassay, radioreceptor assay, bioassay and gel chromatography. In two experimental models representing extremes of plasma insulin concentrations (obese hyperinsulinaemic mice and diabetic insulinopenic rats) there were no significant changes in the concentration of insulin receptors in brain while liver receptors were modified in the expected way. This may reflect the protective influence of the blood-brain barrier or some special quality of brain insulin receptors. Insulin concentrations in brain were also unchanged in both models, which is probably indicative of the local synthesis of insulin. The role of insulin in the CNS is unknown. Besides well known metabolic actions of insulin, new roles can be postulated such as neurotransmission, neuromodulation and paracrine signalling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254492
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  • 13
    Electronic Resource
    Electronic Resource
    Subpopulations of antibodies directed against evolutionarily conserved regions of the insulin molecule in insulin-treated patients (1982)
    Springer
    Diabetologia 23 (1982), S. 488-493 
    Details
    ISSN: 1432-0428
    Keywords: Insulin antibodies ; insulin structure ; evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the present study, we attempted to define possible subpopulations of antibodies which theoretically could be directed against evolutionarily conserved regions of the insulin molecule in sera from insulin-treated diabetic patients using a variety of labelled and unlabelled insulins which differ widely in structure but are very similar in functional properties. Ten high titre human insulin antisera from patients treated with mixed beef-pork insulin were examined. All sera were found to bind 125I-pork insulin better than labelled chicken insulin which bound better than labelled fish insulin. Detailed studies were conducted with four of the antisera using the pork and fish tracers. With two of the antisera, a subpopulation of antibody could be detected with 125I-fish insulin which had similar affinity for both fish and pork insulin, but reacted much less well with guinea pig insulin and the desoctapeptide derivative of porcine insulin. Based on the known properties of these four insulins, the data provide suggestive evidence consistent with the hypothesis that there are subpopulations of antibodies recognizing regions on the insulin molecule that are well conserved, possibly the region involved in the formation of insulin dimers or receptor binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254296
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  • 14
    Electronic Resource
    Electronic Resource
    The consequences of the discovery by W. C. Röntgen for present-day medical physics and radiation protection (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 640-651 
    Details
    ISSN: 1420-9071
    Keywords: History ; medical physics ; radiation protection ; radiology ; Röntgen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract When the German physicist W. C. Röntgen discovered X-rays, which were named after him, he introduced a new development in medicine and biology: together with the discoveries of A. H. Becquerel and M. Curie, radiology with its diagnostic and therapeutic methods was made possible. The medical physicist has an important task to fulfill in modern radiotherapy, nuclear medicine and radiodiagnostics. The longtime interdisciplinary collaboration has won the international recognition of medical physics as a scientific discipline, a health care profession and a university subject. Several incidents, including contemporary ones, show that the efforts made towards radiation protection must remain an important domain of the specialist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01941262
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  • 15
    Electronic Resource
    Electronic Resource
    British Diabetic Association Abstracts Medical and Scientific Section, Spring Meeting (1968)
    Springer
    Diabetologia 4 (1968), S. 375-380 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211775
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  • 16
    Electronic Resource
    Electronic Resource
    Unusual ultrastructural variants in the ferret parietal cell (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 395-396 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé On décrit deux rares variations structurelles: cristalloïdes cytoplasmiques intracellulaires et mitochondries géantes, observées dans les cellules marginals de la muqueuse gastrique du furet. Les cristalloïdes cytoplasmiques sont probablement en rapport avec la dégénération mitochondrielle, et les mitochondries géantes sont un caractère aberrant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01896909
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  • 17
    Electronic Resource
    Electronic Resource
    Right ventricular function in patients with chronic obstructive pulmonary disease (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 1041-1047 
    Details
    ISSN: 1432-1440
    Keywords: Chronic bronchitis ; Right heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Simultaneous right heart catheterization and radionuclide ventriculography were performed in 27 patients with a wide range of chronic obstructive pulmonary disease. Central hemodynamics and radionuclide studies were done at rest and during exercise. In the resting state the right ventricular ejection fraction (RVEF) was in the normal range (43.3±6%). During exercise a significant (p〈0.001) decrease of RVEF to 38.8±6.7% occurred. The pumonary artery mean pressures were 19.9±3.8 at rest. During exercise a significant (p〈0.001) increase to 41±9.8 mm Hg occurred. There was a linear relationship between pulmonary pressures and RVEF during exercise in patients with pulmonary artery pressures not exceeding 35 mm Hg. In patients with right ventricular end-diastolic wall thickness ≧6 mm a curvilinear relationship between these parameters could be observed with a flattening of the curve at higher pressures (〉35 mm Hg) and lower ejection fractions (〈35% RVEF). Radionuclide venticulography cannot substitute for right heart catheterization. Echocardiography is useful for interpretation of right ventricular ejection fractions in advanced chronic obstructive pulmonary disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01739670
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  • 18
    Electronic Resource
    Electronic Resource
    Molecular conjugates: a targeted gene delivery vector for molecular medicine (1995)
    Springer
    Journal of molecular medicine 73 (1995), S. 479-486 
    Details
    ISSN: 1432-1440
    Keywords: Protein/DNA complex ; Gene therapy ; Ligand ; Receptor-mediated endocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198899
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  • 19
    Electronic Resource
    Electronic Resource
    Eingebrannte dünne Metallfilme als Widerstandsthermometer für Wärmeübergangsmessungen (1985)
    Springer
    Heat and mass transfer 19 (1985), S. 305-308 
    Details
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Es wird eine Technik beschrieben zur Herstellung und Anwendung dünner eingebrannter Metallfilme als Widerstandsthermometer. Diese eignen sich zur Messung von Oberflächentemperaturen bei der experimentellen Untersuchung von Wärmeübertragungsproblemen. Im beschriebenen Anwendungsfall der Kondensation wurde eine Meßgenauigkeit von ±0,023 K erreicht.
    Notes: Abstract A technique is described for manufacturing and applying thin fired metal-paint-films as resistance thermometers. They can be used for measurement of surface temperatures in experimental investigations of heat transfer problems. In the described case of condensation the accuracy of measurement was ±0.023 K.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01002286
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  • 20
    Electronic Resource
    Electronic Resource
    The redox status of aminothiols as a clue to homocysteine-induced vascular damage? (1998)
    Springer
    European journal of pediatrics 157 (1998), S. S102 
    Details
    ISSN: 1432-1076
    Keywords: Key words Homocysteine ; Atherosclerosis ; Redox thiol status ; Endothelium ; Nuclear factor κB ; Protein folding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Vascular disease associated with increased blood concentrations of homocysteine has been known for many years. However, the pathobiochemical mechanisms leading to vasculopathy are still unknown. Several attempts have been made to establish in vitro model systems for the evaluation of homocysteine specific effects in cultured cells. It was concluded from these experiments, that hyperhomocysteinemia has to be considered as a risk factor for atherosclerosis exerting its effects mainly by mechanisms involving oxidative damage. Here, we summarize the homocysteine induced cellular effects which may be due to alterations of the redox thiol status. Effects specific for homocysteine are demonstrated working on different levels of cellular processes involving protein folding and regulation of nuclear factor κB (NF-kB) controlled gene transcription, the latter opening a new perspective for a novel pathway by which homocysteine might enhance chronic inflammation of the endothelium and possibly contributes to the development of atherosclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00014294
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