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  • Electronic Resource  (8,181)
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  • 1995-1999  (3,863)
  • 1980-1984  (4,318)
  • Analytical Chemistry and Spectroscopy  (6,605)
  • Theoretical, Physical and Computational Chemistry  (1,576)
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  • Electronic Resource  (8,181)
  • Loose Leaf
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Year
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  • 101
    Electronic Resource
    Electronic Resource
    Determination of Amitraz in Cattle Dipping Baths by High-Performance Liquid Chromatography (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 247-249 
    Details
    ISSN: 0935-6304
    Keywords: High performance liquid chromatography-ultraviolet detection (HPLC-UV) ; Amitraz ; cattle dipping bath ; pesticide ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---No abstract
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 102
    Electronic Resource
    Electronic Resource
    On-Line Coupled Liquid Chromatography - Gas Chromatography in the Analysis of Process Samples (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 261-264 
    Details
    ISSN: 0935-6304
    Keywords: On-line coupled LC-GC ; normal phase liquid chromatography ; process samples ; oxygenated compounds ; partially concurrent solvent evaporation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Normal phase liquid chromatography-gas chromatography was used with on-column interfacing and partially concurrent solvent evaporation in the analysis of process samples. Samples were taken from reaction mixtures, where the solvent was toluene. The analytes were oxygenated compounds: methyl isobutyrate, methyl methacrylate, methyl α-formyl isobutyrate, and methyl β-formyl isobutyrate. The analytes were transferred from LC to GC using back-flush with a solvent mixture of pentane and diethyl ether. Linearity, repeatability, and transfer efficiency were determined for the method. The method was applied in the determination of the analytes of two different process samples. The results were in good agreement with results obtained by the gas chromatographic method currently in use for the analysis of the process samples.
    Additional Material: 2 Ill.
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    Paper (German National Licenses)
  • 103
    Electronic Resource
    Electronic Resource
    Determination of the Critical Micelle Concentration of Cationic Surfactants by Capillary Electrophoresis (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 265-270 
    Details
    ISSN: 0935-6304
    Keywords: Critical micelle concentration ; cationic surfactant ; capillary electrophoresis ; tetradecyltrimethylammonium bromide ; dodecyltrimethylammonium bromide ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---The determination of the critical micelle concentration (CMC) of cationic surfactants by capillary electrophoresis was demonstrated. In this study, tetradecyltrimethylammonium bromide (TTAB) and dodecyltrimethylammonium bromide (DoTAB) were selected as cationic surfactants and propazine was chosen as test solute. In the evolution of the effective electrophoretic mobility of propazine as a function of surfactant concentration, a dramatic change in slope at a particular concentration is a good indication of the CMC of this surfactant. The CMC values determined experimentally were further confirmed by a curve-fitting approach. Simulation of the electrophoretic mobility curves as a function of surfactant concentration in both micellar electrokinetic chromatography and capillary zone electrophoresis using cationic surfactants as an electrolyte modifier was performed for propazine, and the intersection of these two mobility curves allowed us to precisely predict the CMC of the surfactant. The CMC values determined for TTAB and DoTAB are 1.6 ± 0.1 and 11.0 ± 0.1 mM, respectively, in the case of an electrolytic solution consisting of 70 mM phosphate buffer at pH 6.0. Moreover, the applicability of the electroosmotic mobility as a parameter for the determination of the CMC was examined.
    Additional Material: 6 Ill.
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  • 104
    Electronic Resource
    Electronic Resource
    A Unified Sample Preparation System for Extraction of Various Analyte/Matrix Combinations (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 271-275 
    Details
    ISSN: 0935-6304
    Keywords: Supercritical fluid extraction ; enhanced solvent extraction ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A supercritical fluid extraction/enhanced solvent extraction system (SFE/ESE) was used to remove polar and non-polar analytes from various matrices. Extraction of environmental pollutants from soil, additives from low density polyethylene, sulfa drugs from animal tissue, and drug from tablet was performed using both SFE and ESE. Results showed that a single instrumental system can be used to perform both ESE with organic solvents and SFE with carbon dioxide-based fluids. Each method has its own unique advantages and applications. The ability to carry out both solvent extraction and supercritical fluid extraction with one system has obvious economical advantages.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 105
    Electronic Resource
    Electronic Resource
    An Improved Interface for Coupling Solid-Phase Microextraction (SPME) to High Performance Liquid Chromatography (HPLC) Applied to the Analysis of Explosives (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 279-282 
    Details
    ISSN: 0935-6304
    Keywords: Solid phase microextraction (SPME) ; SPME/HPLC interface ; C-8 refocusing unit ; explosives analysis ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---No abstract
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 106
    Electronic Resource
    Electronic Resource
    Analysis of the Naturally Occurring Pesticide Rotenone by Capillary Gas Chromatography (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 294-296 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography ; capillary ; fused silica ; rotenone ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 107
    Electronic Resource
    Electronic Resource
    Isolation of Polychlorodibenzo-p-dioxins and Polychlorobiphenyls upon Deproteinization of a Serum Sample by HPLC with Restricted-Access Reversed-Phase Packing Materials (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 287-293 
    Details
    ISSN: 0935-6304
    Keywords: Deproteinization ; polychlorobiphenyls ; polychlorodibenzo-p-dioxins ; restricted-access reversed-phase packings ; sample preparation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---No abstract
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 108
    Electronic Resource
    Electronic Resource
    A Fast and Reliable Method for the Determination of Anionic Impurities and Neutralization Agents in Electrodipcoats Using Capillary Zone Electrophoresis with Conductivity Detection (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 297-299 
    Details
    ISSN: 0935-6304
    Keywords: Capillary electrophoresis ; conductivity detection ; inorganic anions ; organic acids ; electrodipcoats ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---No abstract
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 109
    Electronic Resource
    Electronic Resource
    Supercritical Fluid Extraction and Supercritical Fluid Chromatography of Vitamin E in Pharmaceutical Preparations (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 300-302 
    Details
    ISSN: 0935-6304
    Keywords: Supercritical-fluid-extraction ; supercritical-fluid-chromatography ; vitamin E ; pharmaceuticals ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 110
    Electronic Resource
    Electronic Resource
    Teicoplanin-Based Enantiomeric Separations in CZE Using a Partial Filling Technique (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 315-321 
    Details
    ISSN: 0935-6304
    Keywords: Glycopeptide antibiotics ; chiral selectors ; Teicoplanin ; enantioseparations ; CZE ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Baseline separation of the enantiomers of a number of negatively charged amino and mandelic acid derivatives was achieved in less than 10 min by capillary electrophoresis in a polyacrylamide coated capillary, using the “partial filling method” (PFM) with submillimolar concentration of Teicoplanin (TE) as the chiral selector. The influence of the charge and concentration of TE, electrolyte solution composition and pH, on the enantioresolution was examined. Further proofs were brought to corroborate the hypothesis that the enantiorecognition takes place at the D-Ala-D-Ala binding site, whose blockade is responsible for the antibacterial activity of glycopeptide antibiotics. While the dependence of the chiral recognition capabilities of TE on electrolyte solution composition and pH could limit its applicability, improved sensitivity, reduction of TE wall adsorption, resulting in a good efficiency, and high cost reduction, due to the very small amount of chiral selector required, were shown as advantages of the PFM adopted in this study.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 111
    Electronic Resource
    Electronic Resource
    Solvent Trapping during Large Volume Injection with an Early Vapor Exit. Part 3: The Main Cause of Volatile Component Loss during Partially Concurrent Evaporation (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 327-334 
    Details
    ISSN: 0935-6304
    Keywords: Large volume on-column injection ; partially concurrent solvent evaporation ; solvent trapping ; retaining precolumn ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---When 0.53 mm i.d. uncoated precolumns connected to a solvent vapor exit are used for sample introduction with partially concurrent solvent evaporation, substantial losses of volatile solutes are often observed. They were found to be the consequence of solute accumulation at the front end of the flooded zone, which in turn is the result of a strong pressure drop over the flooded zone owing to the formation of plugs of sample liquid. The pressure drop causes significant solvent evaporation at the front, which enriches the solute material there and causes its loss. The use of 0.32 mm i.d. restrictions between the uncoated precolumn and the vapor exit greatly reduced this problem.
    Additional Material: 10 Ill.
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  • 112
    Electronic Resource
    Electronic Resource
    Preparation of On-Column Frits in Packed Fused Silica Capillaries by Sol-Gel Technology (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 438-442 
    Details
    ISSN: 0935-6304
    Keywords: Capillary electrochromatography ; micro-HPLC ; preparation of on-column frits ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Existing methods for preparing frits in packed fused silica capillaries as used for electrochromatography and micro HPLC are not applicable to all silica based packing materials and involve a high thermal stress for both the stationary phase and the fused silica tubing including the polyimide coating. A new procedure for the production of such on-column frits under mild conditions by a sol-gel type reaction of polydimethoxysiloxane (PDMOS) is described in this paper. Reaction conditions were established for optimum mechanical stability and high permeability of the frits. Frits produced in this manner showed no noticeable effect on the overall efficiency.
    Additional Material: 1 Ill.
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  • 113
    Electronic Resource
    Electronic Resource
    Application of Temperature and Applied Voltage Programming in Micellar Electrokinetic Capillary Chromatography (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 443-448 
    Details
    ISSN: 0935-6304
    Keywords: Micellar electrokinetic capillary chromatography ; temperature programming ; applied voltage programming ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Temperature and voltage programming modes were utilized to optimize selectivity and increase the eluting rate of strongly retained compounds in micellar electrokinetic chromatography. Separations obtained by applying temperature, voltage, and a simultaneous combination of temperature and voltage gradient in micellar electrokinetic capillary chromatography were compared with separations performed under isothermal and constant voltage conditions. A complete separation of all the constituents of the test mixture was only achieved in the temperature programming run and in a combination of temperature and voltage programming modes. Simultaneous variations of column temperature and applied voltage during a separation run, yielded a 30% reduction in the total analysis time when compared to a temperature gradient alone. Temperature programming and voltage programming modes may be the gradient methods of choice because of the considerable technical difficulties involved in performing linear solvent gradient elution in micellar electrokinetic chromatography.
    Additional Material: 7 Ill.
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  • 114
    Electronic Resource
    Electronic Resource
    Fast Temperature Programming in Gas Chromatography using Resistive Heating (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 459-464 
    Details
    ISSN: 0935-6304
    Keywords: Fast gas chromatography ; gas chromatography ; resistive heating ; organophosphorus pesticides ; PAHs ; triazines ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---The features of a resistive-heated capillary column for fast temperature-programmed gas chromatography (GC) have been evaluated. Experiments were carried out using a commercial available EZ Flash GC, an assembly which can be used to upgrade existing gas chromatographs. The capillary column is placed inside a metal tube which can be heated, and cooled, much more rapidly than any conventional GC oven. The EZ Flash assembly can generate temperature ramps up to 1200°/min and can be cooled down from 300 to 50°C in 30 s. Samples were injected via a conventional split/splitless injector and transferred to the GC column. The combination of a short column (5 m×0.25 mm i. d.), a high gas flow rate (up to 10 mL/min), and fast temperature programmes typically decreased analysis times from 30 min to about 2.5 min. Both the split and splitless injection mode could be used. With n-alkanes as test analytes, the standard deviations of the retention times with respect to the peak width were less than 15% (n = 7). First results on RSDs of peak areas of less than 3% for all but one n-alkane indicate that the technique can also be used for quantification. The combined use of a short GC column and fast temperature gradients does cause some loss of separation efficiency, but the approach is ideally suited for fast screening as illustrated for polycyclic aromatic hydrocarbons, organophosphorus pesticides, and triazine herbicides as test compounds. Total analysis times - which included injection, separation, and equilibration to initial conditions - were typically less than 3 min.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 115
    Electronic Resource
    Electronic Resource
    Determination of Deuterated Phenylalanine and Tyrosine in Egg Protein by GCQ (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 465-468 
    Details
    ISSN: 0935-6304
    Keywords: Amino acid ; stable isotope ; GC-MS ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---In order to study protein digestibility by means of noninvasive tracer techniques (stable isotopes), a representative oral tracer, i.e. a stable isotope labeled protein, is needed. Therefore, egg white containing L-[ring-2H5]phenylalanine and L-[ring-2H4]tyrosine was prepared. The aim of this study was to measure the isotopic enrichment of the labeled amino acids in the egg white. The use of a standard GC-MS, based on ion trap technology was found to be a reliable technique. The enrichment of L-[ring-2H5]phenylalanine and L-[ring-2H4]tyrosine, expressed in Molar Percent (MP) amounted to 23.2 MP and 2.8 MP respectively.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 116
    Electronic Resource
    Electronic Resource
    Development of a Methodology for the Identification of Volatiles in Industrial Adhesive Formulations by GC/MS with Manual Headspace Sampling (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 477-480 
    Details
    ISSN: 0935-6304
    Keywords: Adhesives ; GC/MS ; headspace analysis ; poly(vinyl acetate) ; volatile organic compounds ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---No abstract
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 117
    Electronic Resource
    Electronic Resource
    High Resolution Separation of Non-Polar Lipid Classes by HPLC-ELSD Using Alumina as Stationary Phase (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 483-486 
    Details
    ISSN: 0935-6304
    Keywords: HPLC ; alumina ; evaporative light-scattering detection ; non-polar lipids ; wax esters ; sterol esters ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---This study describes the performance and capacity of alumina as stationary phase in an HPLC-ELSD (evaporative light-scattering detection) method optimized for the separation of the non-polar lipid classes hydrocarbons, wax esters, sterol esters, triacylglycerols, and sterols, including quantitative determination of these lipid classes in natural samples. By using gradient elution and constant equilibration times between injections, highly reproducible separations of triacontane, stearyl oleate, and cholesterol oleate were accomplished with a binary mobile phase system. Phase A contained 0.5% tetrahydrofuran in hexane and phase B 20% isopropanol and 20% tetrahydrofuran in hexane. The same system was also used to determine the non-polar lipid classes in a zooplankton sample, the major lipid class being wax esters, followed by triacylglycerols, sterol esters, sterols, and hydrocarbons. Substantial amounts of an unknown compound, possibly acylated glyceryl ethers, were also found. The equilibration time of alumina was relatively slow compared to a polyvinyl alcohol stationary phase used earlier by the authors and calibration curves for different lipid classes were more uniform and linear with alumina.
    Additional Material: 4 Ill.
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  • 118
    Electronic Resource
    Electronic Resource
    Prediction of Migration Times of Organic Ions in Capillary Zone Electrophoresis (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 495-500 
    Details
    ISSN: 0935-6304
    Keywords: CZE ; mobility ratio ; migration time prediction ; mathematical model ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---The electrophoretic mobility ratio (R value) of any two ions is constant and independent of the capillary type and electrophoretic conditions if their electrical charges and hydration radii are constant. The use of strong acid salts and quaternary ammonium salts is therefore proposed for the determination of R values. Such analytes are called markers. The following determinations can be carried out: (i) the determination of the migration time corresponding to the electroosmotic flow (EOF) in any capillary under any electrophoretic condition by measuring the migration times of two markers in the condition studied (useful when the EOF is weak); (ii) the determination of the migration time of an analyte in any capillary by knowing the migration time of the markers in the capillary studied. If the pH is changed and the ionization of the analyte is pH dependent, the resulting migration time for the analyte can be calculated. The constancy of the mobility ratios of seven markers was checked experimentally at eight different pH values (between pH 3 and 10), at three temperatures, and for two buffer concentrations. The predicted and experimental migration times were also compared in two different types of capillaries.
    Additional Material: 2 Ill.
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  • 119
    Electronic Resource
    Electronic Resource
    Possibilities and Limitations of Fast Temperature Programming as a Route towards Fast GC (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 509-513 
    Details
    ISSN: 0935-6304
    Keywords: Fast GC ; fast temperature programming ; resistive heating techniques ; short columns ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---One possible way to speed up a gas chromatographic analysis is the application of fast temperature programming by using resistive heating techniques. With this heating technique programming rates up to 20° per second can be reached. A relative standard deviation of retention times better than 0.2% is obtained. Using fast temperature programming the analysis-times of a mineral oil sample, an industrial oligomer sample, and toxic compounds in diesel fuel have been reduced 5 to 20 times, compared to a standard temperature programmed analysis. In most cases resistive heating cannot be applied to reduce the analysis time of a complex sample. The use of fast temperature programming is preferable to the use of short columns and columns operated at above-optimum carrier gas velocities.
    Additional Material: 6 Ill.
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  • 120
    Electronic Resource
    Electronic Resource
    Trace Determination of Organic Compounds in Water by Direct Enrichment in Multichannel Thick Film Silicone Rubber Traps with Capillary Gas Chromatography (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 521-526 
    Details
    ISSN: 0935-6304
    Keywords: Multichannel silicone trap ; water analysis ; flow rate ; methanol ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The application of Multichannel Silicone Rubber Traps for the direct analysis of organic compounds in water was studied. The optimum collection flow rate for a 10 mL sample was found to be ca. 150 μL·min-1. The effect of methanol on the retention power of the trap was evaluated. The addition of a methanol fraction of up to 40% to the water standards did not show any loss in collection efficiency. It was shown that the extraction of organic compounds from water with the multichannel trap is uncomplicated, i. e. methanol is not required to achieve accurate analyses, concentration of the sample onto the trap is by gravity flow, and excess water remaining in the multichannel trap after water extraction is removed by centrifugation. With the use of the multichannel silicone rubber trap a wide boiling point range of compounds were analyzed from aqueous samples at levels of 1-4 μg·L-1.
    Additional Material: 5 Ill.
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  • 121
    Electronic Resource
    Electronic Resource
    Improved Procedure for Single DB-XLB Column GC-MS-SIM Quantitation of PCB Congener Distributions and Characterization of Two Different Preparations Sold as “Aroclor 1254” (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 533-540 
    Details
    ISSN: 0935-6304
    Keywords: Chlorobiphenyl congeners ; Aroclor 1254 ; DB-XLB phase ; GC-MS-SIM ; PCB 126 ; toxic equivalency ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Complete PCB congener distributions in a panel of Aroclor mixtures were previously obtained by combining data from several HRGC systems. In that study quantitation of minor components may have been unreliable due to single level calibration against high levels of individual congener standards. Two lots of Aroclor 1254 had markedly different congener distributions. In this study, the design and performance of a congener-specific PCB analysis method employing GC-MS-SIM detection of congeners separated on a DB-XLB capillary column are discussed. Quantitation is carried out against a 6-level inclusive standard curve of a mixture of 144 congeners found in Aroclors. A separate procedure to measure trace levels of PCB 126 in Aroclors using the same system, combined with levels initially acquired for other congeners, facilitates estimation of TEQ values (Toxic Equivalencies of the PCB mixtures to 2,3,7,8-TCDD). PCB congener profiles of 15 Aroclor 1254 mixtures are presented. These profiles show that the less common, high TEQ variety of Aroclor 1254 was manufactured by an atypical, two-stage chlorination process that was apparently used during the final 1% of Aroclor 1254 production (ca. 1974-1976).
    Additional Material: 5 Tab.
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  • 122
    Electronic Resource
    Electronic Resource
    Prototypical Test Substances for a Reversed Phase in a Retention Parameter Model (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 454-458 
    Details
    ISSN: 0935-6304
    Keywords: Liquid chromatography ; reversed phase ; prototypical substances ; retention parameter model ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A set of four prototypical substances (naphthalene, acetanilide, phenol, and benzonitrile) is selected from 26 different analytes used by Seibert and Poole for characterization of the retention behavior of 20 liquid chromatographic systems of a C18 reversed phase with methanol/water and acetonitrile/water as mobile phases. Retention data of 22 different analytes can be calculated from the retention data of the set of prototypical substances with a mean standard deviation of 5.4%. Two phase system maps similar to that suggested by Poole et al. are provided for an octadecylsiloxane-bonded silica sorbent with methanol and acetonitrile as cosolvents with water.
    Additional Material: 2 Ill.
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  • 123
    Electronic Resource
    Electronic Resource
    Determination of Organic Peroxides by Gas Chromatography with Cold On-Column Injection (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 475-476 
    Details
    ISSN: 0935-6304
    Keywords: Organic peroxides ; gas chromatography ; FID ; cold on-column injection ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---No abstract
    Additional Material: 1 Ill.
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  • 124
    Electronic Resource
    Electronic Resource
    Modifier and Additive Effects in the Supercritical Fluid Extraction of Pseudoephedrine Hydrochloride from Spiked-Sand and Suphedrine Tablets (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 469-474 
    Details
    ISSN: 0935-6304
    Keywords: Supercritical fluid extraction ; SFE modifiers ; pseudoephedrine ; suphedrine ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---The effect of modifier and additive composition upon pseudoephedrine recovery from spiked-sand and Suphedrine tablets was examined. Recovery was shown to be dependent on CO2 density as well as on the addition of an ion pairing agent to the matrix. The presence of methanol in the extraction vessel prior to SFE was shown to play a significant role in the ion-pair extraction process. Recovery was also shown to be a function of ion-pairing reagent composition and concentration. The most successful recovery was obtained in the presence of 1-heptanesulfonic acid (HSA), sodium salt in methanol at a 5:1 molar ratio (reagent to drug). The increased extractability in the presence of ion-pairing reagent was attributed to reduced analyte polarity and analyte-matrix displacement. Alternatively, a matrix-spiked mixture of methanol and 1% water by itself was just as effective as a matrix-spiked mixture of methanol and HSA for attaining efficient extraction. Several in-cell (e. g. to the matrix) and in-line (e. g. to the fluid) modifiers were examined for the extraction of pseudoephedrine from Suphedrine tablets. The greatest pseudoephedrine recovery from Suphedrine tablets of 82% (7.0%) was achieved with 10% (l% H2O) methanol-modified CO2 in the presence of 400 μL of methanol (l% H2O). Finally AgCl tests and infrared analyses were performed on two tablet extracts. It was confirmed that even in the absence of any in-cell modifier, a small fraction of pseudoephedrine hydrochloride could be extracted.
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    Chiral Separation of Carboxymethyl Derivatives of Amines by Liquid Chromatography on Reversed-phase Silica Gel Coated with N-n-Dodecyl-L-hydroxyproline (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 487-489 
    Details
    ISSN: 0935-6304
    Keywords: Carboxymethyl derivatives of amines ; dodecyl-L-hydroxyproline ; chelate ring ; chemiluminescence ; ruthenium complex ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Carboxymethyl derivatives of amines containing a chiral α-carbon were separated into enantiomers by high-performance liquid chromatography using octadecylsilanized silica gel coated with N-n-dodecyl-L-hydroxyproline as the stationary phase and an aqueous solution containing copper(II) as the mobile phase. Detection was by post-column reaction involving derivatization to tertiary amine and chemiluminescence reaction of ruthenium bipyridine complex.
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    Indirect Fluorimetric Detection of Cyclodextrins via Postcolumn Mixing with 2-p-Toluidinyl-6-naphthalenesulfonate in Liquid Chromatography (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 609-612 
    Details
    ISSN: 0935-6304
    Keywords: Cyclodextrins ; 2-p-toluidinyl-6-naphthalenesulfonate ; indirect fluorimetric detection ; liquid chromatography ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Cyclodextrins (CD's) were visualized by postcolumn mixing with 2-p-toluidinylnaphthalene sulfonate (TNS) in liquid chromatography. The indirect detection is based on fluorescence enhancement due to the formation of an inclusion complex between TNS and CD's. β-CD gave larger signal intensity than α- and γ-CD. Different selectivities were observed for alkyl-bonded silica stationary phases with different chain length.
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    Analysis of Methylcitric Acid by Enantioselective Multidimensional Gas Chromatography-Mass Spectrometry (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 604-608 
    Details
    ISSN: 0935-6304
    Keywords: Enantioselective multidimensional gas chromatography-mass spectrometry (enantio-MDGC-MS) ; methylcitric acid (MCA) ; inherited metabolic disease ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Methylcitric acid (2-hydroxybutane-1,2,3-tricarboxylic acid-MCA) is a structural analogue of citric acid, but due to an additional methyl group it is a chiral molecule with two stereogenic centers and thus four stereoisomers are conceivable. MCA occurs naturally as prominent metabolite in body fluids of patients with inherited metabolic diseases such as propionic acidemia, methylmalonic aciduria, or holocarboxylase synthetase deficiency. Therefore methylcitric acid is considered to be an important diagnostic marker for these diseases. MCA is most likely produced from accumulated propionyl-CoA in these diseases by the enzyme si-citrate synthase from the citric acid cycle; however, there are other enzymes known which could catalyze the same reaction with different stereoselectivity, such as re-citrate synthase or the more specific enzyme methylcitrate synthase, found in microorganisms. Almost all methods dealing with MCA in the literature are non-enantioselective. For that reason there is no information about occurrence of MCA enantiomers in healthy people, patients with propionic acidemia, methylmalonic aciduria, or holocarboxylase synthetase deficiency and about value of enantiomeric distribution for diagnosis and long-term treatment. The enantioselective analysis of MCA as corresponding trimethyl ester was achieved by enantioselective multidimensional gas chromatography coupled with mass spectrometry using heptakis-(2,3-di-O-methyl-6-O-tert-butyl-dimethylsilyl)-β-cyclodextrin as chiral stationary phase. The described method allows a reliable screening of MCA in complex matrices like urine without time consuming sample preparation and with mass selective detection. During this investigation urine samples from various patients and healthy controls were analyzed. As concluded, MCA is a good diagnostic marker and can be easily measured by the method presented. Only the two stereoisomers (2S,3R) and (2S,3S) were detectable in patients and healthy controls. The varying ratios of these stereoisomers cannot presently be correlated with the health status of patients, although there are some indications that this might be possible. However, the quantitative levels of MCA, determined as the ratio of MCA absolute peak area divided by 1,000 to the creatinine contents of urine samples in this investigation, showed a dependence on the state of health and MCA would thus also be a possible marker for long-term treatment. Such a substance is of major interest nowadays since there are different studies searching for such a long-term marker in propionic acidemia or methylmalonic aciduria.
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    Relative Recoveries of Hydrocarbons from Geological Samples Using High Temperature Supercritical Fluid Extraction: Contributions from Thermal Desorption (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 623-627 
    Details
    ISSN: 0935-6304
    Keywords: Supercritical fluid extraction ; hydrocarbons ; high temperature ; thermal desorption ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The extraction of n-alkanes, polyaromatic hydrocarbons (naphthalene, methylated naphthalenes, phenanthrene, methylated phenanthrenes, anthracene, and methylated anthracenes) and biomarkers (hopanes) from Posidonia shale by high temperature supercritical fluid (HT-SFE) carbon dioxide extraction has been evaluated, including the relative contributions from thermal desorption and relative comparisons to conventional Soxhlet extraction. These current results confirm those of previous studies indicating a widely differing extractability of strongly and weakly associated hydrocarbons in ancient sediments and the significantly higher recoveries possible using HT-SFE compared to conventional Soxhlet extraction. The present study also demonstrates that these high HT-SFE recoveries are due to true extraction rather than simple thermal desorption and that this procedure is a useful tool to study speciation as well as total extractable hydrocarbons from sediments.
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    Stereoisomeric Flavor Compounds LXXXII Dill Ether and Its Stereoisomers: Synthesis and Enantioselective Analysis (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 631-634 
    Details
    ISSN: 0935-6304
    Keywords: Dill ether ; stereoselective synthesis ; dill ether stereoisomers ; enantioselective multidimensional gas chromatography-mass spectrometry (enantio-MDGC/MS) ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---No abstract
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    Complete Separation of Isomeric Penta- and Hexachloronaphthalenes by Capillary Gas Chromatography (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 639-643 
    Details
    ISSN: 0935-6304
    Keywords: Cyclodextrin ; Halowax ; hexachloronaphthalene ; PCN ; polychlorinated naphthalenes ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---No abstract
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    Separation of Positional Isomers on A, C- and A,D-Bridged Calix[6]arene as Stationary Phases in Capillary GC (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 679-682 
    Details
    ISSN: 0935-6304
    Keywords: A,C- and A,D-bridged calix[6]arene ; stationary phase ; capillary gas chromatography ; geometric and positional isomer separation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A,C-Bridged (ACCX) and A,D-bridged isopropyldimethylsilylcalix[6]arene (ADCX) dissolved in OV-1701 were used as stationary phases in isothermal capillary gas chromatographic separation of some positional isomers. Retention factors and separation factors for the isomers were measured. The isomers investigated are well resolved on the two phases. Retention of all the solutes investigated is longer on ACCX than on ADCX. The longer retention on A,C-bridged calix[6]arene is probably due to extra inductive interactions of the solute molecule with the carbonyl moieties in the phase. Separation factors for closely eluting isomer pairs are similar on the two phases. This seems to indicate that the carbonyl moieties do not play an appreciable role in discriminating the isomer molecules on entering the cavity of the calixarene if the solute is retained by the inclusion process.
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    Two-Dimensional Gas Chromatography. Concepts, Instrumentation, and Applications - Part 1: Fundamentals, Conventional Two-Dimensional Gas Chromatography, Selected Applications (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 647-665 
    Details
    ISSN: 0935-6304
    Keywords: Two-dimensional GC ; statistical method of overlap ; petroleum ; fuels ; enviromental samples ; organochlorine compounds ; flavors ; aromas ; foods ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---The writer of this review published in 1978 a three-part article on two-dimensional gas chromatography in the first three issues of this journal [1]. The review was written at a time when capillary column GC was still in its infancy. Commercial columns were (essentially) unavailable and sample introduction into capillary columns was done exclusively in the split mode. Two-dimensional separations were explored in only a few laboratories. The limitations of capillary column technology made this exercise rather difficult. The introduction of fused silica capillary columns in the early eighties drastically changed the landscape in which gas chromatography was practiced. It took the chromatographic community just a few years to convert from packed columns to capillary columns. Instrumentation and accessories specifically designed for capillary column use came onto the market. This writer had great hopes that the revolution in capillary column GC would be mirrored in the development of instrumentation for Two-Dimensional Gas Chromatography. This never materialized. On the contrary, tentative steps taken by a few manufacturers and suppliers of chromatographic equipment fizzled out. It was perhaps the introduction of relatively inexpensive and user friendly GC/MS instrumentation, in combination with nearly indestructible fused silica capillary columns that took away the incentive to develop commercially viable Two-Dimensional Gas Chromatography. Much of the thinking went like this: why insist on good chromatography if mass spectrometry can do the job without the need for complete separation. Some progress in the further development of conventional Two-Dimensional Gas Chromatography has certainly been made over the last 20 years but there has not been a great deal of excitement. Applications have also been relatively sparse and they are limited to just a few areas. Science does not remain static and chromatography is no exception. Progress in gas chromatography is driven by new technology and ideas. Substantial improvements in two-dimensional GC were not forthcoming until Phillips and his research group introduced and implemented an entirely new form of Two-Dimensional Gas Chromatography, called comprehensive two-dimensional GC, or GC×GC. This breakthrough occurred only in 1991 [2]. It does take some time before scientists change attitudes and habits. There is always a time lag between the introduction of new technology and its general acceptance. The public's attitude toward comprehensive Two-Dimensional Gas Chromatography is probably no exception. The number of scientists who are actively pursuing this new branch of gas chromatography is still very small. It is often a single individual who carries the torch. J.B. Phillips' name is synonymous with comprehensive Two-Dimensional Gas Chromatography. He is not only its inventor and proponent but his fertile mind has initiated research in other related areas. Sadly, he passed away shortly before this review was written. This contribution is dedicated to his memory.
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    Unexpected rate enhancement in the intramolecular carboxylic acid-catalyzed cleavage of o-carboxybenzohydroxamic acid (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 216-222 
    Details
    ISSN: 0894-3230
    Keywords: o-carboxybenzohydroxamic acid ; phthalic anhydride ; phthalic acid ; hydrolysis ; intramolecular acid catalysis ; kinetics ; activation parameters ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Phthalic anhydride was detected spectrophotometrically in the hydrolysis of o-carboxybenzohydroxamic acid (OCBA) in CH3CN-H2O solvent containing 0.03 mol dm-3 HCl. Pseudo-first-order rate constants (k1) for hydrolysis of OCBA are almost independent of the change in CH3CN content from 10 to 80% (v/v) in mixed aqueous solvents. The rate constants k1 are more than 10-fold larger than the corresponding rate constants for hydrolysis of phthalamic acid. These observations are explained in terms of a mechanism slightly different from the mechanism for hydrolysis of phthalamic acid. The activation parameters, ΔH* and ΔS*, are not affected appreciably by an increase in CH3CN content from 10 to 80% in mixed aqueous solvents. © 1998 John Wiley & Sons, Ltd.
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    Solute-solvent and solvent-solvent interactions in binary solvent mixtures. Part 7. Comparison of the enhancement of the water structure in alcohol-water mixtures measured by solvatochromic indicators (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 185-192 
    Details
    ISSN: 0894-3230
    Keywords: solute-solvent interactions ; solvent-solvent interactions ; binary solvents ; alcohol-water mixtures ; water structure ; solvatochromic indicators ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A preferential solvation model that takes into account the enhancement of the structure of water when small amounts of alcohol are added was applied to solvatochromic data for binary mixtures of water with 2-methylpropan-2-ol, propan-2-ol, ethanol and methanol. Application of the model allows the calculation of the effect of the enhancement of the water structure on solvatochromic solvent properties. It is demonstrated that the enhancement of water structure increases the solvent dipolarity/polarizability and hydrogen-bond donor acidity and decreases the solvent hydrogen-bond acceptor basicity. The effect decreases in the order 2-methylpropan-2-ol-water, propan-2-ol-water, ethanol-water and methanol-water. © 1998 John Wiley & Sons, Ltd.
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    Structural dependence of heterolytic bond dissociation energy of carbon-carbon σ bonds in hydrocarbons (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 157-170 
    Details
    ISSN: 0894-3230
    Keywords: heterolytic bond dissociation energy ; carbon-carbon σ bonds ; hydrocarbons ; structural dependence ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The coordination of a resonance-stabilized hydrocarbon cation and anion yielded a series of unprecedented hydrocarbons, which are susceptible to thermal heterolytic cleavage of carbon-carbon σ bonds in polar media, generating the original ions under reversible conditions. When the component ions were sufficiently stabilized, some ion pairs were even isolated as solids, thus providing the first examples of hydrocarbon salts. The direct observation of the heterolysis by means of spectroscopy permitted reliable thermodynamic treatments of the observed degree of ionic dissociation. Correlation of the free energy of heterolysis with solvent dielectric constants and parameters of ion stabilities such as pKHA, pKR+ and redox potentials revealed the importance of the thermodynamic stabilities of ions, the degree of solvation and steric congestion in the starting molecule as major controlling factors in the heterolysis. © 1998 John Wiley & Sons, Ltd.
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    Correlation of the rates of solvolysis of the N,N-diphenylcarbamoylpyridinium ion (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 273-276 
    Details
    ISSN: 0894-3230
    Keywords: N,N-diphenylcarbamoylpyridinium ion ; solvolysis ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Solvolyses of the N,N-diphenylcarbamoylpyridinium ion are subject to specific and/or general base catalysis, which can be eliminated by addition of perchloric acid or increased, especially in fluoroalcohol-containing solvents, by addition of pyridine. The uncatalyzed solvolyses in aqueous methanol and aqueous ethanol involve a weakly nucleophilically assisted (l  =  0.22) heterolysis and the solvolyses in the pure alcohols are anomalously slow. © 1998 John Wiley & Sons, Ltd.
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    Effects of ionic and non-ionic micelles on rate of hydroxide ion-catalyzed hydrolysis of securinine (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 209-215 
    Details
    ISSN: 0894-3230
    Keywords: securinine ; cationic micelles ; anionic micelle ; non-ionic micelle ; alkaline hydrolysis ; kinetics ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The effects of micelles of cetyltrimethylammonium bromide (CTABr), tetradecyltrimethylammonium bromide (TTABr), sodium dodecyl sulfate (SDS) and polyoxyethylene 10 lauryl ether (C12E10) on the rates of alkaline hydrolysis of securinine were studied at a constant [-OH] (0.05 M). An increase in the total concentrations of CTABr, TTABr, SDS and C12E10 from 0.0 to 0.2 M causes a decrease in the observed pseudo-first-order rate constants (kobs) by factors of ca 2.5, 3, 7 and 4, respectively. The observed data are explained in terms of pseudophase and pseudophase ion-exchange (PIE) models of micelle. The binding constants, KS, of securinine with SDS, C12E10, CTABr and TTABr micelles are 32.4, 14.8, 22.1, and 9.1 M-1, respectively. The magnitudes of the second-order rate constants, kM, for the reactions in the micellar pseudophase are negligible compared with the corresponding rate constant, kW, for the reaction occurring in the aqueous pseudophase for CTABr, TTABr, SDS and C12E10. © 1998 John Wiley & Sons, Ltd.
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    Colloidal CdS-induced photocatalytic reaction of 2-methylindole - mechanistic analysis of oxidation of indoles (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 277-282 
    Details
    ISSN: 0894-3230
    Keywords: colloidal CdS-induced photochemical reactions ; photocatalytic reactions ; photooxidation ; 2-methylindole ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: 2-Methylindole (2-MI) is adsorbed on the surface of colloidal CdS particles with an adsorption intensity of 0.6 × 103 dm3 mol-1. A new emission band at 530 nm is produced by forming an exciplex between excited CdS and 2-MI and the red emission due to CdS is simultaneously quenched. The emission maxima of green bands for different indoles increase in the order indole 〈 tryptophan 〈 2-MI 〈 3-MI and are observed at 508, 520, 530 and 540 nm, respectively. The shift in emission maxima is related to the oxidation potential of these substrates. The irradiation of an aerated reaction mixture containing CdS and 2-MI with visible light induces the oxidation of adsorbed 2-MI by photogenerated holes to produce 2-methyl-3-indolinone and 2-acetamidobenzaldehyde. The latter product is formed due to oxidative C - C bond cleavage of the pyrrole ring. The reactivity of trapped holes towards the adsorbed 2-MI is evidenced by a decrease in the lifetime of the red emission of CdS in the presence of 2-MI. In this reaction the possibility of the participation of singlet oxygen is ruled out. A general mechanism of CdS-induced oxidation of indoles is discussed. © 1998 John Wiley & Sons, Ltd.
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    The Menschutkin reaction of benzyl p-toluenesulfonates with N,N-dimethylanilines. Evidence for the duality of SN1 and SN2 mechanisms (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 254-260 
    Details
    ISSN: 0894-3230
    Keywords: Menschutkin reaction ; duality of SN1, SN2 mechanisms ; benzyl tosylates ; Yukawa-Tsuno equation ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The rate data for the Menschutkin reaction between strongly activated Z-substituted benzyl p-toluenesulfonates and Y-substituted N,N-dimethylanilines in acetonitrile at 35 °C fit the equation, kobs  =  k1 + k2 [DMA], which is consistent with concurrent first- and second-order processes. The k1 and k2 values for each substrate were separated based on the above equation. The SN1 rate constant, k1, is unaffected by the nature of the nucleophile, whereas the SN2 rate constant, k2, increased with the electron-donating substituent of the N,N-dimethylaniline. The substituent effect on the k1 values is linearly correlated by the Yukawa-Tsuno equation with ρ  =  -5.2 and r  =  1.3. The unimolecular reaction can be regarded as a classical SN1 mechanism. In contrast, that on the k2 values shows an upward curvature when analyzed by the Brown σ+ treatment. These results are ascribed to the simultaneous and independent occurrence of SN1 and SN2 mechanisms in the present Menschutkin reaction. © 1998 John Wiley & Sons, Ltd.
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    Editorial (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 231-231 
    Details
    ISSN: 0894-3230
    Keywords: Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: No Abstract
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    Solvent effects on infrared spectroscopic and calorimetric characteristics of aliphatic ketones in binary solvent mixtures (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 283-289 
    Details
    ISSN: 0894-3230
    Keywords: calorimetry ; IR spectra ; ketones ; solvation ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Solution enthalpies of n-hexane, acetone, butan-2-one and octan-2-one in a series of tetrachloromethane-acetonitrile mixtures and the carbonyl stretching absorption frequencies in the IR spectra of these ketones were determined. It was found that over the whole range of concentrations (varying from neat tetrachloromethane up to neat acetonitrile) the solvation enthalpy of these compounds can be obtained additively from the contributions of the alkyl and carbonyl fragments. The solvent effect on the solvation enthalpy of the carbonyl group was found to be satisfactorily correlated with the corresponding IR frequency shifts of the C=O group. It was also found that the sensitivities of the carbonyl IR frequencies to the solvent composition are different for various ketones. From both IR and calorimetric data, the preferential solvation parameters were evaluated. The differences between the IR spectroscopic and calorimetric data are discussed. © 1998 John Wiley & Sons, Ltd.
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    Solvent effects on C=O stretching frequencies of some 1-substituted 2-pyrrolidinones (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 261-272 
    Details
    ISSN: 0894-3230
    Keywords: 1-substituted 2-pyrrolidinones ; C=O stretching frequencies ; solvent effects ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: In an effort to model solute-solvent interactions, the C=O stretching frequencies of five 1-substituted 2-pyrrolidinones and four other carbonyl-containing compounds were measured for 30 common solvents. These were then correlated with four empirical parameter sets and one theoretical (computational) parameter set. While an empirical parameter set gave the best correlation equations, the theoretical parameter equations are physically and statistically significant. Solvent volume, polarizability and hydrogen bond donor acidity (capacity) terms are significant in the correlation equations. © 1998 John Wiley & Sons, Ltd.
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    Molecular orbital calculations on the P - S bond cleavage step in the hydroperoxidolysis of nerve agent VX (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 232-240 
    Details
    ISSN: 0894-3230
    Keywords: P - S bond cleavage ; hydroperoxidolysis ; nerve agent VX ; molecular orbital calculations ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The P - S bond cleavage process in the hydroperoxidolysis of a model system for the nerve agent VX was studied using ab initio and semiempirical molecular orbital methods. Aqueous solvation effects were included through single-point calculations using the semiempirical SM5.2PD/A continuum solvation model and geometries optimized at the HF/MIDI! level of theory. The predominant pathway for P - S bond cleavage involves pseudorotation of a low-energy trigonal bipyramidal intermediate followed by apical ligand ejection. In aqueous solution, the free energy barriers for these processes are found to be 14.3 and 4.6 kcal mol-1, respectively, with electronic energies calculated at the MP2/cc-pVDZ//HF/MIDI! level of theory. By comparison with another continuum model of solvation (PCM), it is concluded that the SM5.2PD/A model performs well even for hypervalent phosphorus species, in spite of not having included any such molecules in the model's parameterization set. © 1998 John Wiley & Sons, Ltd.
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    Conformational analysis of a 12-membered crown dithioether in the solid state and in solution (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 241-253 
    Details
    ISSN: 0894-3230
    Keywords: crown dithioether ; conformational analysis ; multicomponent equilibrium ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The solid-state molecular structure and the conformational behaviour in solution of the 12-membered crown dithioether 8-methyl-1,4-dioxa-7,10-dithiacyclododecane-5,12-dione were studied by x-ray crystallography, 1H and 13C NMR spectroscopy and molecular mechanics. The conformational rigidity of some constituent structural fragments allowed a detailed analysis of the structure and distribution of the conformers. A protocol for studies of multiconformational equilibrium was developed by means of the combined use of structure calculations and dynamic NMR measurements. © 1998 John Wiley & Sons, Ltd.
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    Metal-catalyzed carbenoid reactions with iodonium and sulfonium ylides (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 321-333 
    Details
    ISSN: 0894-3230
    Keywords: metal-catalyzed carbenoid reactions ; iodonium ylides ; sulfonium ylides ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Transition metal-catalyzed decomposition of phenyliodonium and diphenylsulfonium ylides was investigated with regard to application in asymmetric carbenoid reactions. Phenyliodonium ylides react in the presence of Rh(II) catalysts with the same selectivity in inter- and intramolecular cyclopropanations as the corresponding diazo compounds, and intramolecular CH insertions proceed with identical enantioselectivities. With diphenylsulfonium ethoxycarbonylmethylide the Cu(I)-catalyzed cyclopropanation of olefins affords trans/cis ratios and asymmetric inductions identical with those of diazo compounds, but with Rh(II) catalysts some small, although significant, selectivity variations occur, which are ascribed to coordination of diphenyl sulfide to one of the coordination sites of the catalyst. © 1998 John Wiley & Sons, Ltd.
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    In vivo formation of C - S bonds in biotin. An example of radical chemistry under reducing conditions (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 529-535 
    Details
    ISSN: 0894-3230
    Keywords: biotin ; in vivo C - S bond formation ; radical chemistry ; reducing conditions ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The last step in the biosynthesis of biotin involves the formation of carbon-sulfur bonds at non-activated carbons catalyzed by biotin synthase. S-Adenosylmethionine (AdoMet) and an electron source are essential for activity in cell-free systems. This important finding connects biotin synthase to a family of enzymes, namely pyruvate-formate lyase, anaerobic ribonucleotide reductase and lysine 2,3-aminomutase, which use the same cofactors. Additional experimental data led to the proposition of the following general mechanism. The carbons to be functionalized are first activated by homolytic cleavage of the C - H bonds, initiated by the deoxyadenosyl radical produced by a monoelectronic reductive cleavage of AdoMet with NADPH as electron source. The electron transfer system involves flavoproteins and very likely the [Fe - S] center of biotin synthase. NADPH and the flavoproteins can be replaced by photoreduced deazaflavin. By using a deuterated substrate, a deuterium transfer into deoxyadenosine has been observed, indicating that biotin synthase should be closely related to lysine 2,3-aminomutase, which uses AdoMet as a surrogate of vitamin B12. The source of sulfur, the nature of the immediate sulfur donor and hence the mechanism of trapping of the intermediate radicals are still unknown. © 1998 John Wiley & Sons, Ltd.
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    Chemistry of secologanin. Part 5. Graphical analysis of the acidic deglycosylation of vincoside derivatives (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 622-631 
    Details
    ISSN: 0894-3230
    Keywords: secologanin ; vincoside derivatives ; acidic deglycosylation ; graphical analysis ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Acidic hydrolysis and cyclization were studied in vincoside glycosides (‘natural’ series) and their dihydro derivatives (‘dihydro’ series) in which either one or both N atoms were free or blocked by an alkyl group. For interpretation of the results, a graph was constructed in which 25 points (actually circles) represent a maximum of 81 aglycone types and 40 arrows indicate 131 possible cyclizations. The reaction matrix of the graph was under thermodynamic control and in most cases afforded the thermodynamically most stable product aglycones. In addition to the deglycosylation, two types of cyclization were observed. In azacyclizations, the preferred nucleophilic site is N-4 over N-1, and the preferred electrophilic site is C-22 in the glycosides, C-21 over C-19 and C-17 in aglycones. In oxacyclizations, the preferred nucleophilic site is O-17 over C-18 and C-21, and the preferred electrophilic site is C-19 over C-21 and C-17 in the ‘natural’ series, C-21 over C-17 in the ‘dihydro’ series. In one case, the kinetically favoured aglycone types which had been generated in the reaction mixture were trapped in a subsequent reaction (outside the graph) before thermodynamic equilibrium was attained. With the help of graphical analysis it was possible to justify the formation of the most favourable and actually isolated products and pathways out of a large number of possibilities. © 1998 John Wiley & Sons, Ltd.
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    Reactant-solute encounters in aqueous solutions studied by kinetic methods: hydration cosphere overlap and camouflage effects (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 841-846 
    Details
    ISSN: 0894-3230
    Keywords: reactant-solute encounters ; aqueous solutions ; water ; kinetic methods ; hydration cosphere destructive overlap ; camouflage effects ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Rates of chemical reactions in aqueous solutions are often sensitive to low concentrations of added solutes such as ureas, alcohols, α-amino acids and carbohydrates. In this work, several simple chemical reactions were used to probe this sensitivity, which arises from interactions between added solute and the reacting solute. It was found that derived interaction parameters provide a novel insight into interactions between solute molecules in aqueous solution. For example, it was possible to identify two interesting effects, which are termed (i) ‘destructive overlap’ of hydration cospheres and (ii) ‘camouflage effects’ by water-solute interactions. Copyright © 1998 John Wiley & Sons, Ltd.
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    Absolute proton affinities of some substituted toluenes: the additivity rule of thumb for ipso attack (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 663-669 
    Details
    ISSN: 0894-3230
    Keywords: ipso proton affinities ; additivity ; disubstituted toluenes ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The problem of the ipso protonation of toluene and its predominantly disubstituted derivatives was considered by the MP2(fc)/6-31G**//HF/6-31G*+ZPE(HF/6-31G*) theoretical model. The substituents involved covered a wide range of different donor-acceptor capabilities. It is shown that the calculated MP2 ipso proton affinities of substituted toluenes follow mutatis mutandis the same additivity rule which was found earlier to be operative in polysubstituted benzenes, naphthalenes and biphenylenes. The additivity equation is both intuitively appealing and useful, being able to offer quantitative estimates of the proton affinity by very simple calculation. It is based on the concept of the increment, which in turn describes the influence of a single substituent on the proton affinity. Any substituent behaves as a rule as if the other were non-existent, thus giving rise to the independent substituent approximation (ISA). The performance of the additivity rule of thumb is very good, as evidenced by the average absolute deviation of 1 kcal mol-1. Larger deviations are possible, but they rarely occur, being indicative of a difference in interactions between substituents in the initial neutral base and in the final cationic conjugate acid. Finally, it follows as a corollary of the present analysis that protonation ipso to the CH3 group is never thermodynamically the most favourable site of proton attack in the benzene ring, provided that there is a single unsubstituted carbon atom within the aromatic moiety. The relevance of ipso protonation in persubstituted benzenes is briefly discussed. © 1998 John Wiley & Sons, Ltd.
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    Photoinduced electron transfer and strand cleavage in pyrenyl-DNA complexes and adducts (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 561-565 
    Details
    ISSN: 0894-3230
    Keywords: pyrenyl-DNA complexes and adducts ; photoinduced electron transfer ; strand cleavage ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The fluorescence of pyrenyl residues in complexes with the nucleic acid bases G, C and T, but not A, is strongly quenched by photoinduced electron transfer mechanisms. Site-specifically modified 11-mer oligonucleotide duplexes containing a single modified guanosyl base G* bearing a covalently attached pyrenyl residue were prepared in order to probe for photochemical damage associated with these photoinduced electron transfer reactions. When the pyrenyl residue positioned at G* is photoexcited with 355 nm light, direct strand cleavage is observed at that site with low quantum yield. Frank strand breaks are also observed up to five base pairs away from G*, suggesting that intrastrand migration of a reactive intermediate from base to base is occurring. © 1998 John Wiley & Sons, Ltd.
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    From olefin cyclopropanation to olefin metathesis through catalyst engineering: recent applications of olefin metathesis to fine organic synthesis and to polymer chemistry (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 602-609 
    Details
    ISSN: 0894-3230
    Keywords: olefin metathesis ; olefin cyclopropanation ; catalyst engineering ; fine organic synthesis ; polymer chemistry ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: An overview of the recent synthetic breakthroughs brought about by the discovery of new, functional group tolerant late transition metal (Rh and Ru)-based catalysts is proposed. Whereas dirhodium(II)-based complexes promote only carbene transfer reactions to olefins (i.e. olefin cyclopropanation), a few ruthenium-based catalysts can be engineered and fine tuned so as to mediate either carbene-transfer reactions or olefin metathesis. The different outcome of the reactions can be rationalized by the capability of the metal center to coordinate or not both the carbene and the olefin. This quite simple-minded approach indicates that several available coordination sites at the metal center favors metathesis reactions to the prejudice of olefin cyclopropanation. Examples of recent applications in ring opening metathesis polymerizations and copolymerizations include the formation of postpolymers of polydienes, of carbohydrate-substituted polymers and of telechelic oligomers. Application of the same ruthenium-based catalysts in ring-closing metathesis is illustrated by the formation of crown ether analogs, of unsaturated peptides and amino acids, of β-lactams, and of different bicyclic systems.
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    Imperatives for enzymatic catalysis of isomerization of sugars and sugar phosphates (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 512-518 
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    ISSN: 0894-3230
    Keywords: sugar isomerization ; sugar phosphate isomerization ; enzymatic catalysis ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The relative yields of the products of isomerization of D,L-glyceraldehyde in D2O with intramolecular transfer of a hydride ([1-1H]DHA) and with proton transfer ([1-2H]DHA) were determined by high-resolution 1H NMR analyses. A study of the catalysis of this isomerization by deuteroxide ion, buffer anions and Zn2+ established the following: (1) isomerization with proton and hydride transfer occurs at approximately equal rates in dilute solutions of sodium deuteroxide; (2) Brønsted bases catalyze isomerization with proton transfer in a bimolecular reaction; (3) Zn2+ catalyzes isomerization with hydride transfer in a bimolecular reaction; and (4) Zn2+ and acetate ion react in concert to catalyze isomerization with proton transfer in a termolecular reaction. These results show that the various pathways for isomerization with proton and hydride transfer proceed via transition states of similar energies, so that there is no strong imperative for enzymatic catalysis by any particular reaction mechanism. The relevance of these results to the mechanism of action of xylose isomerase is discussed briefly. © 1998 John Wiley & Sons, Ltd.
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    Selective arylation of exocyclic N-position of 2-pyrimidylnitrenium ion photolytically generated from tetrazolo-[1,5-a]pyrimidine in the presence of trifluoroacetic acid (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 478-484 
    Details
    ISSN: 0894-3230
    Keywords: Selective arylation ; exocyclic N-position ; 2-pyrimidylnitrenium ion ; tetrazolo[1,5a]pyrimidine ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Photo-reactions of tetrazolo[1,5-a]pyrimidine (1) with benzene (2a) and substituted benzenes (2b-f) in the presence of trifluoroacetic acid (TFA) gave 2-(2-, 3- and 4-substituted anilino)pyrimidines (3-5) together with 2-aminopyridine (6) and biphenyl (7) or diarylmethanes (8b, 8c and 8e). From the effect of heavy-atom solvent on the reactions, it is reasonable to assume that 3-5 are formed via a singlet species, but 6-8 via a triplet species. The intermediacy of 2-pyrimidylnitrenium ion is consistent with the evidence derived by the above effect, by a Hammett plot with ρ = -2.9 and by effects of solvent nucleophilicity and counter-anions. The selective exocyclic N-arylation giving 3-5 is discussed. © 1998 John Wiley & Sons, Ltd.
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    Kinetics of the hydrolysis of cyclic N-substituted sulfamides: 4-amino-2-cyclohexyl- and 4-amino-2-phenethyl-2,3-dihydro-3-oxo-1,2,5-thiadiazole 1,1-dioxides (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 489-494 
    Details
    ISSN: 0894-3230
    Keywords: Cyclic N-substituted sulfonamides ; 1,2,5-thiadiazole 1,1-dioxide derivatives ; hydrolysis ; kinetics ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The hydrolysis reactions of 4-amino-2-phenethyl- and 4-amino-2-cyclohexyl-2,3-dihydro-3-oxo-1,2,5-thiadiazole 1,1-dioxide (Ia and Ib) were investigated in the range 24-73 °C in buffered aqueous solutions. The observed rate constants (kobs) are independent of pH in the range ca 1-4 pH, but increase with increase in pH above ca 4. A linear log kobs vs pH profile with unit slope is observed from pH ca 4 up to the highest experimental pH (ca 10). The products are the corresponding new compounds: 2-amino-2-[(N-substituted-sulfamoyl)imino]acetic acid salts. The C=N bond of these compounds hydrolyses further, in a slow reaction, to the sulfamide and oxalic acid derivatives. The substrates decompose to the final products without accumulation of the acetic acid derivatives under these experimental conditions. A mechanism is proposed. Rate constants and activation parameters are given for the first reaction step. Owing to steric effects, the reaction rate is higher for the N-phenethyl-substituted derivative than for the 2-cyclohexyl-substituted derivative. © 1998 John Wiley & Sons, Ltd.
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    Rate enhancement of 1,3-dipolar cycloaddition of N-methylindole: the singular role of Grignard reagents (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 455-466 
    Details
    ISSN: 0894-3230
    Keywords: 1,3-dipolar cycloaddition ; N-methylindole ; Grignard reagents ; rate enhancement ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The reactions of 2-N-methylindolyl and 2- and 3-benzo[b]thiophenyl anions with nitrile oxides and nitrilimines were performed in order to investigate whether the use of anionic dipolarophiles modifies a classical 1,3-dipolar cycloaddition. When lithium compounds were used as bases, the heterocyclic anions invariably acted as nucleophilic species; in contrast, when a Grignard reagent was employed, the N-methylindole gave cycloaddition products with an extraordinary rate enhancement. The hypothesis that N-methylindole and ethylmagnesium bromide give an adduct much more reactive than N-methylindole itself was supported by the results of a theoretical investigation. The structure and electron distribution of the adduct were determined by ab initio calculations and compared with those of known Grignard complexes with nitrogen ligands. The performance of different basis sets was tested. The quantum theory of atoms in molecules was used to determine atomic charges and to describe the nature of bonds in terms of the properties of the electron density at the bond critical points. © 1998 John Wiley & Sons, Ltd.
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    The ring inversion of silacycloheptatriene and cycloheptatriene. Comparison of the ‘aromaticity’ of planar and boat conformers estimated by nucleus-independent chemical shift (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 475-477 
    Details
    ISSN: 0894-3230
    Keywords: cycloheptatriene ; silacycloheptatriene ; ring inversion ; aromaticity ; ab initio calculation ; nucleus-independent chemical shift ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Nucleus-independent chemical shifts (NICS) of boat and planar structure of silepins (1) and cycloheptatriene (2) were calculated at the HF/6-31+G* level for the Becke3LYP/6-31G* optimized geometries in order to investigate the correlation between the inversion barrier and aromatic nature in the boat and planar forms of 1 and 2. The NICS of unsubstituted silepin 1a indicated that there is almost no stabilization in the boat form (NICS, -0.5) and that the planar form (NICS, 3.5) is relatively destabilized in comparison with the boat form. On the other hand, the NICS of 2 showed that there is considerable homoconjugative stabilization in the boat form (NICS, -4.2) and destabilization in the planar form (NICS, 8.2). In addition to the geometrical effects resulting from angle strain, these electronic effects are considered to affect the energy barriers for ring inversion, which have been calculated to be 0.9 kcal mol-1 for 1a and 5.2 kcal mol-1 for 2. © 1998 John Wiley & Sons, Ltd.
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    Hydrogen-bonding-based thermochromic phenol-amine complexes (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 737-742 
    Details
    ISSN: 0894-3230
    Keywords: thermochromism ; proton transfer ; hydrogen bond ; phenol ; amine ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Variable-temperature UV-vis, 13C NMR and IR studies showed that proton-transferred complexes were formed between phenols and amines in apolar solvents at low temperature. Upon cooling a solution of p-nitrophenol and diisopropylamine in toluene, the colour of the solution changed from colourless to yellow. This thermochromism was ascribed to the proton transfer in the hydrogen-bonding complex. Under UV-vis conditions, butylamine and imidazole also caused similar thermochromism upon complexation with p-nitrophenol, while triethylamine, quinuclidine and pyridine did not. The thermochromic behaviour was particularly dependent on the stoichiometry of the amine and the phenol: a solution of 3,3′-dibromo-5,5′-dinitro-2,2′-biphenyldiol and diisopropylamine with a molar ratio of 1:1 showed no thermochromism, while solutions with 1:2 or higher ratios showed thermochromism, indicating that excess amine is required to obtain the proton-transferred species. These results revealed that the proton-transferred species forms in apolar solvents at low temperature if an appropriate hydrogen-bonding network between the phenol and the amine can stabilize it. © 1998 John Wiley & Sons, Ltd.
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    Double fragmentation in cation radicals. An example in the NADH analogues series (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 774-780 
    Details
    ISSN: 0894-3230
    Keywords: double fragmentation ; cation radicals ; NADH analogues ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The cation radical of 9-tert-butyl-N-methylacridan, generated electrochemically or photochemically, offers, in the presence of strong bases, a remarkable example of a double fragmentation. Whereas in acidic or weakly basic media the tert-butyl radical is cleaved with concomitant formation of the methylacridinium cation, the presence of a strong base triggers the cleavage of both the methyl group borne by the nitrogen atom and the tert-butyl group on C-9 leading to acridine, formaldehyde and the tert-butyl anion, even though methylacridinium cation is stable under these conditions. The origin of this unprecedented behavior resides in the prior deprotonation of the methyl group borne by the nitrogen atom which outruns the usual deprotonation at the 9-carbon because this is slowed by the steric hindrance due to the presence of the tert-butyl group. © 1998 John Wiley & Sons, Ltd.
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    Effect of sulfuric acid on reactions of peroxymonosulfate ion with sulfides and thiol esters (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 803-808 
    Details
    ISSN: 0894-3230
    Keywords: peroxymonosulfate ion ; oxidation ; sulfuric acid ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Peroxymonosulfate ion, HSO5-, as Oxone in aqueous H2SO4, oxidizes sulfides [MeSC6H4X(p), X = Me, H, NO2] to sulfoxides and converts aryl thiobenzoates [PhCOSC6H4X(p), X = Me, H] and thiol phosphorus(V) esters [Ph2POSPh, (EtO)2POSPh, Ph2POSEt, Ph(EtO)POSEt] into the acids and sulfonate ions. Second-order rate constants increase with increasing concentration of H2SO4 (10-53 wt%), owing to the high polarity of the medium rather than to acid catalysis. The rate increases fit the Grunwald-Winstein equation based on YOTs solvent parameters derived from rate effects on SN1 solvolyses. © 1998 John Wiley & Sons, Ltd.
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    Cation radical cycloaddition polymerization: Diels-Alder copolymerization (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 825-830 
    Details
    ISSN: 0894-3230
    Keywords: cation radical cycloaddition polymerization ; Diels-Alder copolymerization ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Diels-Alder cycloaddition copolymerization of a bis(diene) with ionizable bis(dienophiles) via a cation radical mechanism has been accomplished using tris(4-bromophenyl)aminium hexachloroantimonate as a catalyst in dichloromethane solvent. The reactions occur at 0°C and yield Diels-Alder polymers of MW up to ca. 10,000 and a polydispersity index ca. 2. © 1998 John Wiley & Sons, Ltd.
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    Kinetic study of base-promoted elimination reactions of some 1,1,1-trihalo-2,2-bis(dimethoxyphenyl)ethanes in alcoholic solutions (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 54-58 
    Details
    ISSN: 0894-3230
    Keywords: 1,1,1-trihalo-2,2-bis(dimethoxyphenyl)ethanes ; base-promoted elimination ; reaction mechanism ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The base-promoted elimination reactions of 1,1,1-trichloro-2,2-bis(dimethoxyphenyl)ethanes were investigated. The bis(3,4-dimethoxyphenyl)ethane was found to be more reactive than the bis(2,5-dimethoxyphenyl)ethane and the latter more reactive than the bis(2,4-dimethoxyphenyl)ethane. Kinetic data relative to 1,1,1-trihalo(chloro or bromo)-2,2-bis(3,4-dimethoxyphenyl)ethanes show that the tribromo reacts faster than trichloro derivative and that the reactions are general-base promoted with Brønsted β values of about 0.6. A kinetic isotope effect, with kH/kD ratio ranging from 3.5 to 5.7, for the base-promoted elimination reaction of 1,1,1-trichloro-2,2-bis(3,4-dimethoxyphenyl)ethane was found. Tunneling occurs for methoxide and ethoxide ion-promoted eliminations. Activation parameters for alkoxy-promoted elimination show a similar trend for chloride and bromide derivatives. The data collected seem to confirm that there is contiguity between E1cBirr and E2 mechanisms. © 1998 John Wiley & Sons, Ltd.
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    Kinetic and thermodynamic study of 2-bromo-2-methylbutane, 2-chloro-2-methylbutane and 3-chloro-3-methylpentane in diols (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 36-40 
    Details
    ISSN: 0894-3230
    Keywords: haloalkanes ; diols ; kinetics ; thermodynamics ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Rate constants, k, were determined for the solvolytic reactions of 2-bromo-2-methylbutane, 2-chloro-2-methylbutane and 3-chloro-3-methylpentane in 10 pure diols at 298.15 K. The Gibbs energies of activation were calculated in order to study the influence of the solvent and to provide mechanistic information about the activation process. By combining these values with a set of infinite dilution activity coefficients, γ∞, the transfer Gibbs energies of the reactants (initial state) and of the activated complex (transition state) were obtained, which allowed the solvent effects on both states to be quantitatively analysed. The γ∞ values were calculated using the UNIFAC group contribution method. The modified Flory-Huggins equation was used in the combinatorial term. The interaction parameters were taken from the specific UNIFAC γ∞ interaction parameter table, except for the γ∞ values of 2-chloro-2-methylbutane and 3-chloro-3-methylpentane in diethylene glycol and triethylene glycol, which were obtained using the γ∞ UNIFAC-VLE interaction parameter tables. For comparative purposes all the other infinite dilution activity coefficients of the three solutes in the diols were also calculated using the UNIFAC-VLE parameter tables. © 1998 John Wiley & Sons, Ltd.
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    Inhibitory effect of DNA structure on the efficiency of reaction of guanosine moieties with a nitrenium ion (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 71-76 
    Details
    ISSN: 0894-3230
    Keywords: guanosine ; nitrenium ; DNA structure ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The N-acetyl-N-(2-fluorenyl)nitrenium ion (2a) reacts very efficiently with monomeric 2′-deoxyguanosine (d-G) to form a C-8 adduct, N-(2′-deoxyguanosin-8-yl)-2-acetylaminofluorene (6), in an aqueous environment, with a selectivity ratio, kd-G/ks, of 13.1 × 103 M-1 at 0°C and 4.8 × 103 M-1 at 30°C. The reactivity of the self-complementary oligomer d-ATGCAT with 2a can be separated into components due to the single-stranded (SS) and double-stranded (DS) forms. Within the error limits of the measurements kSS/kd-G ≈ 0.27 and kDS/kd-G ≈ 0. Another measure of the reactivity of d-G moieties in the DNA double helix can be obtained from measurements with the circular super-coiled plasmid pUC19. This plasmid provides an upper limit for kpUC19/kd-G of 0.02, where kpUC19 is the average trapping rate constant per d-G moiety in pUC19. The strong inhibition of the trapping reaction caused by the tertiary structure of the DNA double helix may be responsible for the change in product distribution of 2a-d-G adducts found from reaction with d-G, and denatured DNA (exclusive C-8 adduct, 6) and native DNA [5-20% N-2 adduct,3-(2′-deoxyguanosin-N2-yl)-2-acetylaminofluorene, 7]. © 1998 John Wiley & Sons, Ltd.
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    Effects of urea, Na+ and Li+ ions on the kinetics and mechanism of intramolecular general base-catalyzed glycolysm of ionized phenyl salicylate in ethane-1,2-diol-acetonitrile solvents at a constant water concentration (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 109-114 
    Details
    ISSN: 0894-3230
    Keywords: phenyl salicylate ; ethane-1,2-diol ; urea ; sodium salt ; lithium salt ; transesterification ; kinetics ; intramolecular general base catalysis ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Pseudo-first-order rate constants (k1) for the reaction of ethane-1,2-diol (DOL) with ionized phenyl salicylate (PS-), obtained in mixed DOL-CH3CN solvent at constant [H2O] and [NaOH], obey the relationship k1  =  α[DOL]T/(1 + 2KA[DOL]T), where α is the apparent second-order rate constant, KA is the association constant for the dimerization of DOL and [DOL]T is the total concentration of DOL. The values of KA, in the presence of Na+ ions, decrease with increase in [H2O]. Lithium ions cause almost complete depolymerization of polymeric DOL (i.e. KA ≈ 0) under the experimental conditions imposed. The effect of 0.5 M urea on the structural behavior of the mixed solvent is kinetically insignificant. © 1998 John Wiley & Sons, Ltd.
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    Effects of oligooxyethylene linkage on intramolecular [2 + 2] photocycloaddition of styrene derivatives (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 79-83 
    Details
    ISSN: 0894-3230
    Keywords: [2 + 2] ; photocycloaddition ; quantum yield ; oligooxyehylene linkage ; cyclophane ; styrene derivatives ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: There are two possible explanations for the high yields in the intramolecular [2 + 2] photocycloaddition of compounds 3a-d in which two styrene moieties are bridged by an oligooxyethylene linkage: one is the electronic effects of phenoxy oxygen atoms at the para-position of the vinyl group and the other is the steric effects due to the flexibility of oligooxyethylene linkages. In order to clarify the contributions of the two effects, a study was made of the photoreaction of similar compounds in which oxygen atoms are present only at the ends of the chain, and therefore only the electronic effects are involved. In these compounds, the quantum yields of the photocycloaddition were found to be low. Hence the high yields in the photocycloaddition of 3a-d are concluded to be ascribable to the flexibility of oligooxyethylene linkages. © 1998 John Wiley & Sons, Ltd.
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    Improved method for estimating the ZFS parameter D for delocalized biradicals (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 819-824 
    Details
    ISSN: 0894-3230
    Keywords: zero field splitting parameter, D ; organic biradicals ; triplets ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: An ‘average’ approximation for calculating the zero-field splitting parameter, D, gives reasonable results when used to calculate D values for non-disjoint delocalized organic biradicals. When used to calculate disjoint localized organic biradicals the D values are approximately half the experimental values. © 1998 John Wiley & Sons, Ltd.
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    Correlation analysis of UV spectral data of some phenylhydrazones and semicarbazones by the dual-parameter equation. Observation of three types of behaviors of the λmax values induced by the polar effects of substituents (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 809-818 
    Details
    ISSN: 0894-3230
    Keywords: UV spectra ; dual-parameter equation ; correlation analysis ; polar effect ; spin-delocalization effect ; p-Y-substituted benzaldehyde phenylhydrazones ; p-Y-substituted benzaldehyde 2,4-dinitrophenylhydrazones ; p-Y-substituted benzaldehyde 4-nitrophenylhydrazones ; p-Y-substituted benzaldehyde N-phenylsemicarbazones ; p-Y-substituted benzaldehyde semicarbazones ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The K-band λmax values of the UV spectra of five types of p-Y-benzaldehyde derivatives, namely phenylhydrazones (1-Ys), 2,4-dinitrophenylhydrazones (2-Ys), 4-nitrophenylhydrazones (3-Ys), semicarbazones (4-Ys) and N-phenylsemicarbazones (5-Ys), were measured and the corresponding wavenumbers (νmax) calculated. Correlation analyses of the νmax values by the dual-parameter equation show that the νmax values of these compounds are affected, albeit to different degrees, by both spin-delocalization effects (σ·) and polar effects (σx) of the substituents. The spin-delocalization effects of substituents always facilitate bathochromic shifts of the λmax values (ρ· negative). However, polar effects of the substituents on these λmax data depend on the mode of polarization of these hydrazone or semicarbazone molecules, i.e. electron-pair acceptor substituents (Ys) facilitate bathochromic shifts for 1-Ys (ρx negative), but hypsochromic shifts for 2-Ys and 3-Ys (ρx positive), and induce very small shifts for 4-Ys and 5-Ys. As expected, donor Ys facilitate hypsochromic shifts for 1-Ys and bathochromic shifts for 2-Ys and 3-Ys and induce very small shifts for 4-Ys and 5-Ys. Possibly, a higher degree of polarization of the substrate molecule would demand a higher degree of polar assistance from the substituents at the transition states. © 1998 John Wiley & Sons, Ltd.
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    Comparison of ΔG°Acid (gas phase) and kinetic acidities measured in methanolic sodium methoxide (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 614-617 
    Details
    ISSN: 0894-3230
    Keywords: ΔG°Acid (gas phase) ; kinetic acidities ; methanolic sodium methoxide ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Hydron exchange rates, kexc (M-1s-1), using methanolic sodium methoxide were compared with ΔG°Acid, (kcal mol-1) (gas phase) for 9-phenylfluorene, C6H5CH(CF3)2, m-CF3C6H4CH(CF3)2, p-CF3C6H4CHClCF3, m-CF3C6H4CHClCF3, 3,5-(CF3)2C6H3CHClCF3, fluorene and C6F5H. There is a good linear correlation for p-CF3C6H4CHClCF3, m-CF3C6H4CHClCF3 and 3,5-(CF3)2C6H3CHClCF3, with the others falling off the line. The fluorinated benzyl compounds and pentafluorobenzene have near-unity isotope effects and therefore differ from the fluorenyl compounds. Although the acidity and the exchange rates for three of the compounds [9-phenylfluorene, C6H5CH(CF3)2 and p-CF3C6H4CHClCF3] are similar, the important proton-transfer step to form a hydrogen-bonded carbanion intermediate and the subsequent breaking of that weak bond to form a free carbanion in methanol differ significantly for the fluoernyl compound compared with the two fluorinated benzylic compounds. © 1998 John Wiley & Sons, Ltd.
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    Intramolecular thermal (4σ + 2π) dyotropy: primary 2H kinetic isotope effects. Experimental limiting barrierparameters for quantum tunnelling in 2H transfer processes and mechanistically significant substituent effects (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 879-886 
    Details
    ISSN: 0894-3230
    Keywords: intramolecular thermal (4σ + 2π) dyotropy ; kinetic isotope effects ; limiting barrier parameters ; quantum tunnelling ; 2H transfer processes ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Primary deuterium kinetic isotope effects (PDKIE) in parazoline-annelated syn-sesquinorbornenes exhibiting irreversible intramolecular (4σ + 2π) thermal dyotropy reveal unambiguous evidence for a tunnelling contribution to the kinetics in one instance but not for a close analogue. For analogous dyotropy of a cyclohexadiene-annelated syn-sesquinorbornene, the tunnelling components of the kinetic behaviour is small by comparison. The H atom traverse between alternative loci for the pyrazolines, deduced from x-ray and neutron diffraction data, is in agreement with approximate barrier parameters obtained by fitting of the PDKIE data to the Bell equation; barrier penetration is 3.22 kcal below the computed barrier corrected for the tunnelling contribution. The relative kinetic effect of systematic variation of the π-donor/acceptor groups on aryl ring substituents at C and N in the pyrazoline ring is consistent with a pericyclic process for dyotropy of these compounds, but not with rearrangement mediated by biradicals resulting from single H atom transfer in the rate-limiting step. Computer modelling of the transition state for dyotropy of these compounds is also consistent with a thermal, orbital symmetry conserved pericyclic reaction. Copyright © 1998 John Wiley & Sons, Ltd.
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    Unusual reactivity of highly strained cyclophanesDedicated to Prof. Dr Maitland Jones, Jr, on the occasion of his 60th birthday (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 362-376 
    Details
    ISSN: 0894-3230
    Keywords: highly strained cyclophanes ; reactivity ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: An essential feature of the concept of aromaticity has been the stability and lack of reactivity of aromatics relative to that of other unsaturated compounds. Contrary to this general experience, high and unusual reactivity is encountered when simple, monocyclic benzene rings are bent by short bridges into a boat-shaped conformation, as is the case in small [n] paracyclophanes (n ≤ 8) and [n]metacyclophanes (n ≤ 7). This is illustrated, mostly with examples taken from the authors' own work, for thermal and photochemical behavior and reactions with electrophiles, nucleophiles and dienophiles. © 1998 John Wiley & Sons, Ltd.
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    Heterogeneous catalysis of organic reactions (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 356-361 
    Details
    ISSN: 0894-3230
    Keywords: heterogeneous catalysis ; organic reactions ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A decade's worth of work is reviewed: building on the demonstrated prowess of heterogeneous catalysis in industrial organic chemistry, the author's laboratory devised efficient catalysts for a number of organic reactions, based on aluminosilicates such as clays and zeolites. This review also spells out, at a time when creative research is overshadowed by imitative research, some of the methodological musts that also happen to characterize physical organic chemistry: the devising of experiments so that accurate numerical data can be obtained; the importance of remote, interdisciplinary connections; the need for estrangement from stereotypic preconceptions that may obscure the true explanations for the phenomena; and the over-riding need for concerning oneself only, or at least predominantly, with the important facts that nature tells, if one cares to listen. © 1998 John Wiley & Sons, Ltd.
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    Are phosphatetrahedrane and diphosphatetrahedrane phosphorus or carbon bases? (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 678-683 
    Details
    ISSN: 0894-3230
    Keywords: phosphatetrahedrane ; diphosphatetrahedrane ; phosphorus bases ; carbon bases ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The protonation processes of phosphotetrahedrane (PTH) and diphosphatetrahedrane (DPTH) were studied using density functional theory approaches. The geometries of the neutrals and the protonated species were optimized at the B3LYP/6- 31G(d) level and the final energies were obtained using the B3LYP/6- 311+G(3df,2p) level of theory. Both PTH and DPTH are tetrahedral compounds which behave as carbon bases in the gas phase. In contrast with what was found for other phosphorus-containing cage structures such as tetraphosphacubane, the nature of the basic center does not change when the hydrogen atoms are substituted by bulky substituents. This is a consequence of the fact that both phosphorus and carbon protonation processes lead to C - P bond fission, so that the repulsive interactions between the susbtituents are not significantly different in carbon- or phosphorus-protonated structures. Protonation of DPTH at the P - P bond yields a local minimum with a P - H - P linkage similar to that described before for the most stable protonated form of P4. This seems to indicate that the existence of P - P linkages in strained structures clearly favors the formation of non-classical protonated species where the proton bridges the two phosphorus atoms. © 1998 John Wiley & Sons, Ltd.
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    Improved method of calculating group polarization effects: constants σα (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 485-488 
    Details
    ISSN: 0894-3230
    Keywords: group polarization effects ; polarizability countants ; ab initio ; Sadlej's basis set ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: An improved model is presented for ab initio calculations of the polarizability constants σα using Sadlej's basis set. A new set of constants was calculated for common groups and these were compared with previous 3-21G and 3-21G* calculations and with some experimental equilibrium constants in the gas phase. For the time being, the calculations seem to be the most general approach for obtaining these constants whereas the experimental possibilities are limited in scope. © 1998 John Wiley & Sons, Ltd.
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    1:1 Crystal complex of 2′,6′-dimethoxyflavone and 2,6-dimethoxybenzoic acid. Relationship of pKa to x-ray hydrogen bond data (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 751-755 
    Details
    ISSN: 0894-3230
    Keywords: 2′,6′-dimethoxyflavone-2,6-dimethoxybenzoic acid complex ; crystal structure ; pKa values ; hydrogen bonds ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The crystal structure of the 2′,6′-dimethoxyflavone-2,6-dimethoxybenzoic acid complex was determined. Owing steric hindrance of the methoxy groups, the two H-bonded molecules are twisted. Earlier results were used to establish a relationship between the pKa values of different acids and their hydrogen bond distances in complexes with 2′,6′-dimethoxyflavone. © 1998 John Wiley & Sons, Ltd.
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    Stability and nitrosation efficiency of substituted N-methyl-N-nitrosobenzenesulfonamides (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 756-760 
    Details
    ISSN: 0894-3230
    Keywords: N-methyl-N-nitrosobenzenesulfonamides ; stability ; nitrosation efficiency ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A series of substituted N-methyl-N-nitrosobenzenesulfonamides [2,4,6-(CH3)3, 4-CH3O, 4-CH3, 4-Cl and 4-NO2] were synthesized. All of them transfer their nitroso group to N-methylaniline in a quantitative manner, the more reactive being those substituted with electron-withdrawing groups, thus resembling some of the known alkyl nitrites. Studies of their acid denitrosation and base-catalysed hydrolysis demonstrated that the nitrosobenzenesulfonamides are fairly stable in aqueous media between pH 2 and 11. Their relative stability in aqueous media together with their ability to transfer the nitroso group to nucleophiles suggest their use as excellent alternatives to alkyl nitrites in both neutral and basic media. © 1998 John Wiley & Sons, Ltd.
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    Conformational analysis of substituted 5,6,7,8-tetrahydrodibenzo[a,c]cyclo-octene: comparison of 1H NMR, molecular mechanics and semiempirical methods (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 781-786 
    Details
    ISSN: 0894-3230
    Keywords: eight membered rings ; conformational analysis ; molecular mechanics ; semiempirical methods ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The 6-Mono- and trans-6,7-di-substituted derivatives of 5,6,7,8-tetrahydrodibenzo[a,c]cyclo-octene exist in solution in two different conformations. The experimental ΔGo values obtained from 1H NMR spectra are compared with the ΔEsteric and ΔG values calculated by molecular mechanics and semiempirical quantum mechanics methods respectively. The experimental ΔGo values are reproduced better by the ΔEsteric values. The semiempirical methods predict the order of stability of the conformers correctly except for two cases in the PM3 and AM1 methods, but the estimated values are far from the experimental ones. The standard deviation between the experimental ΔGo values and those calculated by semiempirical methods is less for AM1 and MNDO and greater for PM3 and MINDO/3. The conformational space of the flexible side chains in monoacetoxy 1d, monohydroxy 1e, trans-diacid 2d, trans-dimethyl ester 2e and trans-bis-hydroxymethyl 2f searched by molecular mechanics is not reproduced completely by semiempirical methods. © 1998 John Wiley & Sons, Ltd.
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    Effect of solvent composition on the acidity of phenols in dimethyl sulfoxide-water mixtures (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 847-852 
    Details
    ISSN: 0894-3230
    Keywords: phenols ; acidity ; solvent composition ; supersolvent ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The effect of solvent composition on the acidity of substituted phenols in DMSO-H2O systems was examined. It is shown that in DMSO-H2O mixtures with up to 35 mol% DMSO there is a linear relationship between the pKa values of monosubstituted phenols in the binary solvent mixtures of different compositions and the corresponding pKa values in water. This leads to an equation relating the slope and intercept terms, pKa(DMSO-H2O) = slope[pKa(H2O)] + intercept. The basis of this relationship in the Kirkwood-Westheimer equation is examined. The significance of a possible ‘supersolvent’ is discussed. The applicability of the relationships derived herein to other rate-equilibria relationships and solvent mixtures is considered. Copyright © 1998 John Wiley & Sons, Ltd.
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    Dipole moments of polyenic oligomeric systems. Part I. A one-dimensional molecular wire model (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 853-856 
    Details
    ISSN: 0894-3230
    Keywords: polyenic oligomerics ; dipole moments ; one-dimensional molecular wire model ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Ground-state dipolar moments of oligomeric compounds, containing electron-donor (D) and electron-acceptor (A) groups as two terminal units of the polyenic bridge (D-wire-A), can well be described by means of a one-dimensional molecular wire model, which considers a scattering process of electrons through the charge-transfer conduction channel. The dipole moment of the oligomers (μn) follows a non-linear dependence of the polyenic bridge length (L) according to μn = μ0 + μ∞(1 - e- γL) where μ0 is the dipole moment of the first compound of the series, without a polyenic unit (n = 0), μ∞ is a limit value for L → ∞ and γ is the one-dimensional conduction constant of the π-molecular orbital channel of the molecular wire. This model can be extended to all those conjugated oligomers of the D-wire-A type where the electronic charge of the donor group can induce a soliton wave as far as through the polyenic bridge towards the acceptor group. Copyright © 1998 John Wiley & Sons, Ltd.
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    Conformational effects on the mechanism of acid-catalyzed dehydration of hexitols (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 887-894 
    Details
    ISSN: 0894-3230
    Keywords: D-glucitol ; D-mannitol ; conformation ; dehydration reaction ; molecular mechanics ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The Monte Carlo search of the low-energy regions of D-mannitol (4) and D-glucitol (5) conformational space was undertaken in order to investigate conformational effects on the stereochemistry of the acid-catalyzed dehydrative cyclization reaction of 4 and 5 to the corresponding 1,4:3,6-dianhydrohexitols. It was found that although dominant conformations in water resemble closely the crystal state conformations of 4 and 5, the same is not true in solvents of low polarity. The magnitudes of the calculated energies of the reactive conformations for the dehydrative cyclization reaction suggest an SN2 mechanism with a late transition state. Copyright © 1998 John Wiley & Sons, Ltd.
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    Photochemical removal of the tosyl group from the 5′N position of 5′-aminopyrimidine nucleosides: syntheticapplications (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 618-621 
    Details
    ISSN: 0894-3230
    Keywords: 5′-aminopyrimidines ; p-toluenesulfonyl photoremoval ; 3′-azido-3′-deoxythymidine derivatives ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The p-toluenesulfonyl (tosyl) group, an effective protector of the amine function of thymidine derivatives 2a and b, has proven to be photoremovable. This photoreaction was successfully used in the synthesis of new 5′-amino analogs of 3′-azido-3′-deoxythymidine (AZT), 6a and b. Selective photohydrolysis of 5′N-tosylamides 2a and b was carried out by UV irradiation (〉300 nm) in aqueous acetonitrile in the presence of 1,5-dimethoxynaphthalene as an electron donor. © 1998 John Wiley & Sons, Ltd.
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    Hydrolysis of N-methyl-N-nitroso-p-toluenesulphonamide in micellar media (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 584-588 
    Details
    ISSN: 0894-3230
    Keywords: N-methyl-N-nitroso-p-toluenesulphonamide ; hydrolysis ; micellar media ; pseudophase model ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The acid and basic hydrolysis of N-methyl-N-nitroso-p-toluenesulphonamide (MNTS) was studied in different micellar aggregates (CTACl, CTABr, TTABr, LTABr, and OTACl). The effect of mixed micelles (OTAX-LTAX) was also studied. The kinetic behaviour was explained on the basis of the pseudophase model, from which the binding constants of MNTS to different micelles, the ion exchange constants and the reactivity constants in the micellar pseudophase were obtained. © 1998 John Wiley & Sons, Ltd.
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    Binding of protons and zinc ions to transition states for tautomerization of α-heterocyclic ketones: implications for enzymatic reactions (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 519-528 
    Details
    ISSN: 0894-3230
    Keywords: proton binding ; zinc ion binding ; transition states ; α-heterocyclic ketones ; tautomerization ; enzymatic reactions ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The description of catalysis in terms of binding of a catalyst to the transition state propoposed by Kurz is applied to tautomerization of the α-heterocyclic ketones phenacylpyridine, phenacylpyrazine, phenacylphenanthroline and phenylacetylpyridine catalysed by protons and zinc ions. Binding constants for protonated and zinc-coordinated transition states, KB≠ are reported and Brønsted coefficients are calculated from comparison of KB≠ with binding constants for the keto reactant and enolate anion intermediate. The formal equivalence of the binding formalism to a conventional Brønsted analysis is emphasized, and the results are compared with those from a ‘generalised’ Brønsted plot of rate constants against equilibrium constants for reactions of uncomplexed, protonated and zinc ion-coordinated ketones. This plot confirms that intrinsic reactivities of metal-coordinated and protonated substrates are similar even where differences exist between substrates. Application of a comparable Kurz-Brønsted treatment to enzymatic reactions depends in principle upon (a) dissecting binding contributions to catalysis from approximation of covalently reacting groups and (b) separating binding at the reaction site of the substrate, to which Kurz's treatment applies, from ‘remote’ binding, which, to a first approximation, is unchanged between Michaelis complex and transition state. The Brønsted relationship highlights stabilization of reactive intermediates as a thermodynamic driving force for binding catalysis at the reaction site. A formal expression which describes this stabilization, and also accommodates stabilization by remote binding of the substrate and intermediate by the enzyme, is proposed. Its relationship to the usual expression for application of the Kurz approach to enzyme catalysis, (kcat/k0)/Km = KB≠, is discussed and the usefulness of the Brønsted and Marcus relationships for interpreting KB≠ is emphasized. © 1998 John Wiley & Sons, Ltd.
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    Mono- and polynuclear ruthenium(II) complexes, photo-probes and reagents for targeted DNA sites (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 566-576 
    Details
    ISSN: 0894-3230
    Keywords: ruthenium (II) complexes ; photoreactivity ; targeted DNA sites ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Several luminescent ruthenium(II) complexes were designed whose main characteristic is their photoreactivity towards mononucleotides and DNA. It was clearly demonstrated that this photoreactivity originates from a photoinduced electron transfer from a guanine to the excited complex. This process leads to the formation of an adduct which was characterized. The structure shows that the complex is anchored to the nucleotidic base via one of its polyazaaromatic ligands, thus marking irreversibly the DNA guanines. Interestingly, this property can be used in order to target, for example, (i) specific DNA sequences and (ii) particular DNA topologies. For each purpose a specific Ru(II) complex was designed. Synthetic oligonucleotides derivatized with mononuclear complexes were prepared to target and damage specific DNA sequences containing G sites. In these systems, it is shown that the DNA damage consists of an irreversible photo-crosslinking of the derivatized oligonucleotide with the complementary strand. In order to target portions of important deformation along double-stranded DNA, the dinuclear complex [Ru(phen)2]2HAT4+ was prepared and studied. This complex is too large to penetrate inside the major or minor grooves of a DNA double helix, so that only single-stranded portions of denatured DNA are accessible to this compound. © 1998 John Wiley & Sons, Ltd.
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    Linear free enthalpy relationships: a powerful tool for the design of organic and organometallic synthesisDedicated to Professor Reinhard W. Hoffmann on the occasion of his 65th birthday. Revised version of a Plenary Lecture presented at ESOR VI, Louvain la Neuve, July 1997. (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 642-654 
    Details
    ISSN: 0894-3230
    Keywords: linear free energy relationships ; organic synthesis ; organometallic synthesis ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Structure-reactivity relationships are usually investigated within relatively narrow classes of compounds, where structural variation can unequivocally be assigned to certain electronic and steric effects. We present a novel, semiquantitative approach to predict possible reactions of cationic electrophiles (carbenium ions, metal π-complexes, diazonium ions) with neutral nucleophiles (alkenes, alkynes, arenes, hydrides, organometallics and n-nucleophiles). It is shown that the rate constants for these reactions are given with a precision better than a factor of 10-100 by the linear free enthalpy relationship log k(20 °C) = s (E + N), where E characterizes the strengths of the electrophiles, N characterizes the strengths of the nucleophiles and s is a nucleophile-dependent slope parameter, usually close to 1. This deviation appears tolerable in view of the reactivity range extending over more than 30 orders of magnitude, the large structural variety of compounds included and the neglect of solvent and steric effects. The simultaneous treatment of aliphatic, aromatic and organometallic compounds, which becomes possible in this way, provides new qualitative insights, and it is shown how the rule of thumb that reactions proceed at 20 °C if E + N 〉 -5 can be used for rationalizing and designing organic reactions. © 1998 John Wiley & Sons, Ltd.
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    A perspective on biological catalysis (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 508-511 
    Details
    ISSN: 0894-3230
    Keywords: Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 4 Ill.
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    Radical bromination of 1,1- and 1,2-diphenylethylenes in 1,2-dichloroethaneDedicated to the memory of Professor Giuseppe Bellucci (dièd 3 March 1996). (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 685-692 
    Details
    ISSN: 0894-3230
    Keywords: radical bromination ; diphenylethylenes ; 1,2-dichloroethane ; caged radical intermediates ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The radical bromination of 1,1- and 1,2-diphenylethylenes in 1,2-dichloroethane was investigated on the basis of kinetic and product distribution data. Whereas the ionic process followed a third-order rate law (second order in Br2), the radical bromination was second order in Br2 and zero order in olefin in the reagent concentration range examined. Significant inverse kinetic isotope effects were found for the bromination of 3,4′-bis(trifluoromethyl)-1,1-diphenylethylene and cis-1,2-diphenylethylene under these conditions. At variance with the ionic bromination, which gave mixtures of meso- and d,l-dibromides only the meso-dibromides were obtained both from the cis- and trans-1,2-diphenylethylenes. The kinetic and product distribution data for the radical process are discussed in terms of a mechanism in which caged radical intermediates are formed. © 1998 John Wiley & Sons, Ltd.
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    Kinetic mechanism for dimerization of an α-thioamide substituted benzyl carbocation in aqueous solution (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 701-706 
    Details
    ISSN: 0894-3230
    Keywords: carbocation ; thioamide ; kinetics ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The products of reaction of the α-(N,N-dimethylthiocarbamoyl)-4-methoxybenzyl carbocation (1+) intermediate of solvolysis of α-(N,N-dimethylthiocarbamoyl)-4-methoxybenzyl benzoate esters (1-O2CAr) show a strong dependence on solvent. The only product from reaction in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) is 2-dimethylamino-6-methoxybenzothiophene (2) from intramolecular cyclization of 1+. The reaction of 1+ in 50:50 (v/v) methanol-water (I = 0.50, NaClO4) gives mainly the adducts to solvent. In 50:50 (v/v) trifluoroethanol-water (I = 0.50, NaClO4), 1+ partitions between reaction with solvent (ks, 27% yield), cyclization to form 2 (kc, 3% yield) and nucleophilic addition of 2 to 1+ (kalk, 70% yield) to form dimeric product 3. The yield of 3 in 50:50 (v/v) trifluoroethanol-water (I = 0.50, NaClO4) is independent of the leaving group at 1-O2CAr and remains constant as the concentration of the substrate is increased fourfold. These data show that the rate-determining step for dimerization of 1-O2CAr is ionization of substrate to form 1+ and that the products of the reaction are determined by the rate constant ratio for partitioning of 1+ between addition of solvent and cyclization. The rate constant ratios determined for the partitioning of 1+ in 50:50 (v/v) trifluoroethanol-water (I = 0.50, NaClO4) were ks/kc = 0.8 M-1 and kalk/ks = 540 000 M-1. © 1998 John Wiley & Sons, Ltd.
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    Substituent effects on the electrochemical oxidation of N,N′,N″-triphenyl-1,3,5-triaminobenzenes (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 731-736 
    Details
    ISSN: 0894-3230
    Keywords: substituted 1,3,5-triaminobenzenes ; electrochemistry ; linear free energy correlation ; substituted triphenylamines ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Correlation analysis of the oxidation potentials of a series of N,N′,N″-triphenyl-1,3,5-triaminobenzenes (TPABs) substituted at the para positions of the outer phenyl rings shows a linear free energy relationship with resonance-enhanced substituent parameters (σ+). Reaction parameters (ρ+) for oxidation of TPABs were found to be -1.53, -1.45 and -1.34 (per substituent) in methylene chloride, acetonitrile and propylene carbonate respectively. The resonance enhancement and small magnitude of the ρ+ values are related to a significant but weak delocalization of charge onto the outer phenyl rings in the molecular orbitals of radical cations resulting from the oxidation of TPABs. Data on the oxidation of p-substituted triphenylamines were treated similarly and gave a ρ+ value of -3.27 (per substituent) in acetonitrile, greater than that for TPABs owing to a more significant delocalization of charge onto the phenyl rings in the molecular orbitals of the corresponding radical cations. To demonstrate their predictive value, these linear free energy correlations were used to estimate the oxidation potentials of similarly substituted N,N,N′,N′,N″,N″-hexaphenyl-1,3,5-triaminobenzenes, which are of interest as building blocks for molecular magnetic materials. © 1998 John Wiley & Sons, Ltd.
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    Electrophilic aromatic substitutions: reactions of hydroxy- and methoxy-substituted benzenes with 4,6-dinitrobenzofuroxan: kinetics and mechanism (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 707-714 
    Details
    ISSN: 0894-3230
    Keywords: electrophilic aromatic substitutions ; 4,6-dinitrobenzofuroxan ; σ-complexation ; superelectrophile ; nitrobenzofuroxan ; kinetics of SEAr reaction ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Rate constants have been determined in aqueous Me2SO mixtures for the reaction of super-electrophilic 4,6-dinitrobenzofuroxan (DNBF) with a series of hydroxy- and methoxy-substituted benzenes whose pKa values range between -3 and -9. The study extends the reactivity range of weakly basic aromatics with DNBF, from the family of indoles previously studied with pKa values ranging from -1 to -6. The overall rate constants for the reactions of DNBF as the electrophile are at least one order of magnitude greater than for the reactions of H3O+ with the same series of aromatics. This lends further credence to the notion that DNBF possesses super-electrophilic properties. An LFER is observed between logk50%Me2SODNBF and pKaH2O with slope 0.54. In the case of 1,3,5-trimethoxybenzene a significant kinetic isotope effect (KIE) is observed (kH/kD = 3.71 in 50% Me2SO). This system hence affords one of the few instances in which a KIE has been observed in SEAr reactions. It follows from the observed KIE that the addition of DNBF to the aromatic is not rate-limiting and that reversion to reactants and proton loss from the arenonium intermediate occur at comparable rates. Structures of the products of electrophilic substitution have been confirmed by 1H NMR. In all cases the regiochemistry of the reactions was identical to that observed in protonation studies of the starting aromatics. © 1998 John Wiley & Sons, Ltd.
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    Solvent dependence of pyranine fluorescence and UV-visible absorption spectra (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 743-750 
    Details
    ISSN: 0894-3230
    Keywords: pyranine ; photoacid ; solvent polarity parameters ; solvatochromism ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Fluorescence and UV-visible absorption spectra of HPTS (8-hydroxy-1,3,6-pyrenetrisulphonic acid trisodium salt, pyranine) were measured in a variety of solvents. Fluorescence maxima (in kcal mol-1) can be correlated with the Kosower Z parameter (r = 0.901), the Dimroth-Reichardt ET(30) parameter (r = 0.900) and the Winstein Y parameter (r = 0.916) using one-parameter fits. Good correlations (r = 0.98) were obtained for HPTS fluorescence in ethanol-water mixtures using the Y, YOTs and Z parameters. Fluorescence maxima of HPTS in aqueous sulphuric acid solutions gave an excellent correlation with YOTs (r = 0.991). Multi-parameter correlations, indicating the significance of specific solvent interactions, were also studied. In addition, fluorescence maxima correlate well with maximum/minimum ratios obtained from UV-visible absorption experiments. Results can be applied in the use of HPTS as a molecular probe of solvent environments and for extension of the YOTs scale in acidic solutions. HPTS is a unique molecular probe, not only because of its photoacidic properties and its widespread use as a pH-sensitive biosensor, but also because of its relative stability in acidic environments. © 1998 John Wiley & Sons, Ltd.
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  • 191
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    Ab initio molecular orbital study of the conformational energies (-ΔG° or A values) of 4-alkyltetrahydro-2H-thiopyrans (tetrahydrothiopyrans, thiacyclohexanes, thianes) (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 831-839 
    Details
    ISSN: 0894-3230
    Keywords: conformational energy ; tetrahydrothiopyrans ; ab initio molecular orbital ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Ab initio 6-31G* and MP2/6-31G*//6-31G* methods were used to calculate the relative energies of the rotamers in the chair conformations of 4-alkyltetrahydro-2H-thiopyrans (tetrahydrothiopyrans, thiacyclohexanes, thianes; CH3, C2H5, i-C3H7, t-C4H9, neo-C5H11, SiMe3). The MP2/6-31G*//6-31G* conformational energies (-ΔG° or A values, kcal mol-1) of the 4-alkylthiacyclohexanes (Me = 1.94; Et = 1.72; i-Pr = 1.62; t-Bu = 5.49; neo-Pent = 1.39; SiMe3 = 2.76) are similar to those calculated for the corresponding alkylcyclohexanes. Plots of the calculated conformational energies for the 4-alkylthiacyclohexanes versus the calculated conformational energies for the corresponding alkylcyclohexanes are linear (slope = 1.01 and r = 0.999 for 6-31G* and slope = 1.09 and r = 0.990 for MP2/6-31G*//6-31G*). The conformational energies are strongly influenced by the magnitude and number of repulsive nonbonded hydrogen-hydrogen interactions and the gauche (synclinal) effects in the conformers. The carbon-sulfur bond lengths are mostly in the narrow range of 1.815-1.818 Å. The C - S - C angles vary from 97.1° to 99.4° and the C(3) - C(4) - C(7) angle in the most stable axial conformer is larger that the corresponding angle in its most stable equatorial conformer. © 1998 John Wiley & Sons, Ltd.
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    Non-cross-linked and cross-linked poly(alkylmethyldiallylammonium halides): synthesis and aggregation behavior (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 305-320 
    Details
    ISSN: 0894-3230
    Keywords: poly(alkylmethyldiallylammonium halides) ; aggregation behavior ; polyelectrolytes ; polysoaps ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Hydrophobically modified polyelectrolytes (polysoaps) are a unique class of water-soluble polymers containing distinct hydrophobic and hydrophilic regions. Above a certain concentration, polysoaps form intramolecular and intermolecular aggregates in aqueous solution. They have attracted much attention not only for their ability to mimic some functions demonstrated by biopolymers but also for their important industrial applications. This review highlights some interesting features of novel non-cross-linked and cross-linked poly(alkylmethyldiallylammonium halides) that have been described in recent years. © 1998 John Wiley & Sons, Ltd.
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    Is the brain ready for physical organic chemistry? (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 334-340 
    Details
    ISSN: 0894-3230
    Keywords: brain chemistry ; membrane proteins ; molecular neurobiology ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Efforts to developed detailed insights into the structure and function of the molecules of memory, thought and sensory perception - physical organic chemistry on the brain - are described. By combining more conventional chemical tools with a number of techniques adapted from modern biology, it is now possible to perform systematic structure-function studies on the integral membrane proteins that play a central role in molecular neurobiology. There are substantial challenges associated with such studies, but we believe the potential payoff is considerable. © 1998 John Wiley & Sons, Ltd.
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    Vicarious nucleophilic substitution of hydrogen. Mechanism and orientation (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 341-349 
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    ISSN: 0894-3230
    Keywords: vicarious nucleophilic substitution ; hydrogen ; mechanism ; orientation ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Hydrogens located at activated positions in electrophilic arenes, e.g. ortho and para hydrogens in nitrobenzenes, can be replaced with a nucleophile moiety provided there is at least one nucleofuge X connected to the nucleophilic centre. As the group really leaving in this hydrogen substitution process is not the hydride anion but X, the reaction has been named vicarious nucleophilic substitution of hydrogen (VNS). The concepts on the mechanism of the reaction and their experimental background are presented. Reactivity and orientation - the fundamental questions concerning synthetical applications of VNS - are discussed in light of the supposed mechanistic picture.
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    Preface (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 291-291 
    Details
    ISSN: 0894-3230
    Keywords: Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: No Abstract
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    New DNA-binding ruthenium(II) complexes as photo-reagents for mononucleotides and DNA (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 577-583 
    Details
    ISSN: 0894-3230
    Keywords: DNA binding agents ; ruthenium(II) complexes ; photoreagents ; DNA ; mononucleotides ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The spectroscopic properties of two photoprobes for DNA, Ru(phen)2(PHEHAT)2+ and Ru(TAP)2(PHEHAT)2+ (phen = 1,10-phenanthroline, TAP = 1,4,5,8-tetraazaphenanthrene, PHEHAT = 1,10-phenanthrolino[5,6-b]-1,4,5,8,9,12-hexaazatriphenylene), were examined and compared with those of complexes containing either an extended planar ligand (DPPZ) or π-acceptor ligands. The orbitals involved in the absorption and emission processes for Ru(phen)2(PHEHAT)2+ imply the PHEHAT ligand, whereas the chromophore and luminophore for Ru(TAP)2(PHEHAT)2+ are associated with the Ru(II) → TAP MLCT transition. The two complexes exhibit completely different behaviour in the presence of DNA. Whereas Ru(phen)2(PHEHAT)2+, which does not emit in water, luminesces upon intercalation between the DNA base pairs, the luminescence of Ru(TAP)2(PHEHAT)2+ is quenched by binding to DNA. Emission quenching is also observed in the presence of GMP, with a quenching rate constant of 1.25 × 109 l mol-1 s-1. This strongly suggests the presence of a photo-induced electron transfer from the guanine residues of GMP or DNA to the excited complex and leads to the conclusion that this complex is a good DNA photoreagent. © 1998 John Wiley & Sons, Ltd.
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    Conjugate addition of water to α-carbonylcarbenes (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 610-613 
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    ISSN: 0894-3230
    Keywords: Conjugate addition ; α-carbonylcarbenes ; water ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: α-Carbonylcarbenes (2a-c) generated by UV photolysis of 2-diazophenylacetic acid (1a), its methyl ester (1b) and 4-diazo-3-isochromanone (1c) in aqueous solution undergo conjugate addition of water across the entire carbonylcarbene moiety to give enols (3a-c) of the corresponding α-hydroxycarbonyl compounds. These carbenes are long-lived, with microsecond lifetimes in aqueous solution. © 1998 John Wiley & Sons, Ltd.
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    Flash photolytic generation and investigation of short-lived reaction intermediates: a case study (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 292-298 
    Details
    ISSN: 0894-3230
    Keywords: flash-photolysis ; short-lived reaction intermediates ; mandelic acid ; keto-enol tautomers ; enzyme-catalyzed racemization ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The advantage of adding more structure-diagnostic information to the simple detection of flash photolytically generated transient species by changes in UV-visible light absorbance is illustrated by a case study involving the mandelic acid keto-enol system. An early report based on preliminary evidence proposed that flash photolysis of phenyldiazoacetic acid produces the enol of mandelic acid by hydration of phenylhydroxyketene, itself generated by a photo-Wolff reaction of the diazo acid. Further examination, however, shows that this is only a minor route, and that the major pathway is a new enol-forming reaction involving what appears to be hydration of a carboxycarbene formed by dediazotization of the diazo compound. Hydration of phenylhydroxyketene is nevertheless the reaction by which mandelic acid enol is generated when esters of benzoylformic acid are the flash photolysis substrates. These mechanisms, and also identification of the enol as a tranisent species, are supported by detailed arguments involving acid-base catalysis, solvent isotope effects, and the use of oxygen-18 as a tracer. The work produces a keto-enol equilibrium constant for the mandelic acid system, pKE  =  16.19, and also acidity constants of the enol ionizing as an oxygen acid, pKEa  =  6.39, and the keto isomer ionizing as a carbon acid, pKKa  =  22.57. The bearing of these results on the enzyme-catalyzed racemization of mandelic acid is discussed. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 4 Ill.
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  • 199
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    Electronic Resource
    Gas-phase thermolysis of N-methyl-N-phenyl-tert-butylsulfenamide and morpholinyl-tert-butylsulfenamide (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 407-410 
    Details
    ISSN: 0894-3230
    Keywords: gas-phase thermolysis ; N-methyl-N-phenyl-tert-butylsulfenamide ; morpholinyl-tert-butylsulfenamide ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: N-Methyl-N-phenyl-tert-butylsulfenamide (MPSA) and morpholinyl-tert-butylsulfenamide (MOSA) were thermolyzed in a stirred-flow reactor at temperatures of 340-390 °C and pressures of 7-13 Torr, using toluene as carrier gas, at residence times of 0.3-1.3 s. Isobutene was formed in 99% yield through first-order reactions having the following Arrhenius parameters (A,s-1, Ea, kJ mol-1): MPSA, log A  =  12.41 ± 0.02, Ea  =  158.8 ± 0.2; MOSA, log A  =  12.91 ± 0.22, Ea  =  159 ± 3. It is proposed that the elimination of isobutene takes place by unimolecular reaction mechanisms involving polar, four-center cyclic transition states, forming S-unsubstituted thiohydroxylamines as co-products. Thermochemical parameters, estimated by semiempirical AM1 calculations, are reported for the latter and for the parent molecules. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 1 Ill.
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  • 200
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    Electronic Resource
    NMR and semi-empirical study of the tautomerism of­2,2′-bisbenzimidazolyl (1998)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 11 (1998), S. 411-418 
    Details
    ISSN: 0894-3230
    Keywords: 2,2′-bisbenzimidazolyl ; tautomerism ; NMR ; semi-empirical calculations ; Chemistry ; Theoretical, Physical and Computational Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A dynamic NMR study of the tautomerism of 2,2′-bisbenzimidazolyl in DMSO-d6 and a mechanistic interpretation of the process, based on a stepwise, single-proton transfer and formation of a zwitterionic intermediate, are presented. This interpretation is substantiated by semi-empirical calculations of the postulated intermediate and transition state, that yield results which are compared with previous studies on related aliphatic systems. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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