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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. 139-146 
    ISSN: 0340-1855
    Keywords: Schlüsselwörter ; Rheumatoide Arthritis ; Gentherapie ; Definition der Gentherapie ; Vektorsysteme ; tierexperimentelle Versuche ; erste Ansätze bei RA Patienten ; Key words Rheumatoid arthritis ; gene therapy ; experimental animal models ; ex vivo and ex vitro experiments ; vector systems ; first trials in RA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Based upon our increasing knowledge of mechanisms underlying tissue destruction in RA patients, new therapeutic principles have been developed, aimed at blocking proinflammatory cytokines or using antiinflammatory cytokines. Both principles, however, have proven to be very effective. In addition, the availability of the methodology to transduce cells with genes has initiated first experiments in animal models to test whether gene therapy for arthritis is suitable, followed by a first, very carefully formulated protocol for human RA. Gene therapy for RA has to still be considered as an experimental form of therapy in a very early stage, not allowing even now any serious treatment offer to RA patients. Several problems, such as the question of a suitable vector system have not yet been solved. With more experiments this therapeutic principle might become available and might prove effective even in a disease with a systemic character like RA in the coming years.
    Notes: Zusammenfassung Mit einem zunehmenden Kentnisstand über pathogenetische Mechanismen, die bei der rheumatoiden Arthritis zu einer Gelenkdestruktion führen, haben sich neue Therapieprinzipien entwickeln lassen, die durch eine Blockade von proinflammatorischen Zytokinen oder der Anwendung von antiinflammatorischen Zytokinen den Krankheitsverlauf zum Teil außerordentlich günstig beeinflussen. Mit den zusätzlichen Möglichkeiten, Gene für antiinflammatorische Therapieprinzipien wie den Interleukin 1 Rezeptorantagonisten in Zellen einzubringen, sind auch erste Versuche, basierend auf vorangegangenen Experimenten im Versuchstier, bei Patienten mit einer RA vorgenommen worden, mit dem Ziel die Krankheitsaktivität durch die intraartikuläre Injektion von transduzierten autologen Zellen zu behandeln. Die ersten Versuche sind ermutigend, doch ist es zu früh, dieses Therapieprinzip als eine Behandlungsmethode für die rheumatoide Arthritis anzubieten. Weitere Untersuchungen, nicht zuletzt hinsichtlich der Bereitstellung besserer Vektoren sind notwendig, um eine Gentherapie der rheumatoiden Arthritis zu realisieren.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. 147-158 
    ISSN: 0340-1855
    Keywords: Schlüsselwörter ; Chronische Polyarthritis ; Halswirbelsäule ; okzipitozervikale Fusion ; transorale Densresektion ; Key words Rheumatoid arthritis ; cervical spine ; occipitocervical fusion ; transoral dens resection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This report will relate our experience with the y-plate, which we used in the treatment of 39 patients (32 women and 7 men) with a mean age of 62.6 years (range 47 to 79 years) between 1987 and 1994. All patients had rheumatoid arthritis. Occipitocervical fusion was indicated by instabilities within the occipitocervical region and in cases with additional basilar invagination and/or after transoral dens resection for decompression of the spinal cord. The length of the fusion depended on the pathological changes of the subaxial cervical spine. Before surgery, 35 patients suffered from strong and 4 patients from moderate pain in the neck and/or the back of the head. On a linear scale from 0 to 10, the pain was rated as 8.1 on average (range 4 to 10). 31 patients had an instability of the atlantoaxial region and 19 patients a basilar invagination of the odontoid. A cervical myelopathy was found in 20 cases. One surgeon fused the occiput to C2 in 22 cases, to C3–C5 in 8 cases and to C7–T2 in 9 cases. An important factor in this operation is the integration of atlantoaxial screws in order to resist the translational dislocation of C1/C2. In 13 patients a resection of the odontoid had to be performed to adequately decompress the spinal cord. A reduction of C2 without dens resection was performed in cases with reducible instability C1/2. 32 of the patients could be controlled with a minimum follow-up of 12 months (average 32.2 months, range 12 to 66 months). Out of the other 7, 6 patients had died. At the time of follow-up, the pain was rated as 2.3 on average (range 0 to 10). A myelopathy was present in 2 cases. Six patients required further operations on the cervical spine; 4 patients developed an instability at the level(s) below the fusion and an enlargement of the fusion to these levels had been performed. The fusion rate was 96.9%, despite breakage of the implant in 3 and a screw loosening in 2 patients. According to the criteria of Conaty, the result was satisfying in 25 (75%) and not satisfying in 8 patients (25%). These results show the effectiveness of the occipitocervical fusion with the y-plate in rheumatoid arthritis. A transoral dens resection is only indicated in cases with basilar invagination causing a compression of the spinal cord or in such cases where a compression caused by the dens or the retrodental pannus formation cannot be treated by a reduction of the second cervical vertebra alone.
    Notes: Zusammenfassung Zielsetzung: In einer retrospektiven Studie untersuchten wir die Ergebnisse der okzipitozervikalen Fusion mit der Y-Platte bei 39 Patienten (32 Frauen und 7 Männer) mit chronischer Polyarthritis, die zwischen 1987 und 1994 an der Schulthess-Klinik Zürich mit einem Durchschnittsalter von 62,6 Jahren (47 bis 79 Jahre) operiert wurden. Die Indikation zum chirurgischen Eingriff wurde bei Instabilität des okzipitozervikalen Übergangs und in Fällen mit basilärer Impression und/oder nach transoraler Densresektion gestellt, wobei die Ausdehnung der Fusion vom Ausmaß der pathologischen Veränderungen der mittleren und unteren Halswirbelsäule abhing. Material: Präoperativ klagten 35 Patienten über starke und 4 über mittelstarke Schmerzen im Nacken und/oder Hinterkopf, die auf einer linearen Skala von 0 bis 10 mit durchschnittlich 8,1 (4 bis 10) beurteilt wurden. Bei 31 Patienten war eine atlantoaxiale Instabilität und bei 19 Patienten eine basiläre Impression des Dens in das Foramen magnum vorhanden. Eine zervikale Myelopathie wurde in 20 Fällen diagnostiziert. Die Fusion erfolgte vom Occiput bis C2 in 22, bis C3–C5 in 8 und bis C7–Th2 in 9 Fällen. Bei 13 Patienten wurde vor der dorsalen Stabilisierung eine transorale Densresektion durchgeführt. Ergebnisse: 32 Patienten konnten mit einem Mindestzeitraum von 12 Monaten (durchschnittlich 32,2 Monate, Minimum 12 Monate, Maximum 66 Monate) nachkontrolliert werden. Nach den Kriterien von Conaty wurde in 24 Fällen (75%) ein befriedigendes und in 8 Fällen (25%) ein unbefriedigendes Resultat erzielt. Zum Nachkontrollzeitpunkt wurde der Schmerz mit durchschnittlich 2,3 (0 bis 10) angegeben. Eine Myelopathie war bei 2 Patienten vorhanden. Bei 6 Patienten wurden weitere Operationen an der Halswirbelsäule nötig. Bei 4 Patienten mußte die Fusion nach kaudal verlängert werden, da eine Instabilität in den Segmenten unterhalb der Spondylodese aufgetreten war. Die Fusionsrate betrug 96,9%, obwohl es bei 3 Patienten zu einem Plattenbruch und bei 2 zu einer Schraubenlockerung gekommen war. Schlußfolgerung: Die Ergebnisse zeigen die Effektivität der okzipitozervikalen Fusion bei Patienten mit chronischer Polyarthritis. Eine transorale Dekompression halten wir nur bei den Fällen für indiziert, in denen eine durch den Dens axis oder das retrodentale Pannusgewebe hervorgerufene Kompression des Myelons nicht durch eine Extension behoben werden kann oder in denen eine basiläre Impression mit Myelonkompression vorliegt.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0340-1855
    Keywords: Schlüsselwörter ; Katzenkratzkrankheit ; reaktive Spondarthritis ; Bartonella henselae ; rheumatische Manifestationen ; Key words ; Rheumatic manifestations ; reactive spondylarthropathy ; cat scratch disease ; Bartonella henselae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Cat scratch disease (CSD) is a rarely recognized infectious disease in Germany. Only a few years ago the causative agent, Bartonella henselae, could be isolated. The typical clinical manifestations of CSD consist of skin changes at the inoculation site and a benign lymphadenopathy; other manifestations are rare. We report the case of a 47 year old woman, who developed a reactive spondylarthropathy with synovitis of finger joints, polyarthralgias of large- and medium-sized joints, and inflammatory spinal pain after a cat bite. The rheumatic manifestations resolved after 10 months by treatment with non-steroidal antirheumatic drugs. Only a few cases of rheumatic manifestations associated with CSD have been described in the literature. Because the prevalence of Bartonella henselae infection of cats is high in Europe, rheumatic manifestations might be more frequent. Diagnosis of CSD is now improved by the development of serological tests. We provide an overview of the clinical manifestations and the diagnostic criteria.
    Notes: Zusammenfassung Bei der Katzenkratzkrankheit (KKK) handelt es sich um eine in Deutschland wenig bekannte Infektionskrankheit. Erst vor wenigen Jahren konnte der Erreger, Bartonella henselae, isoliert werden. In der Mehrzahl der Fälle findet sich ein typisches Krankheitsbild mit Hautveränderungen im Bereich von Katzenbiß- oder Kratzwunden und einer benignen Lymphadenopathie. Weniger häufig kommt es zu weiteren Organmanifestationen. Wir berichten über eine 47-jährige Patientin, die nach einem Katzenbiß eine reaktive Spondarthritis mit Synovialitiden der Fingergelenke, Polyarthralgien der mittleren und großen Gelenke und entzündliche Lumbalgien entwickelte. Die rheumatische Symptomatik war zeitlich limitiert und sprach gut auf NSAR an. Bislang sind nur wenige Fälle von Gelenkbeteiligung im Rahmen einer KKK beschrieben worden. Da die Durchseuchung von Katzen mit Bartonella henselae in Europa jedoch hoch ist, könnte es sich um eine häufigere Ursache von Gelenkbeschwerden handeln, als bislang angenommen. Die Diagnostik der KKK wurde in den letzten Jahren durch die Entwicklung serologischer Teste erleichtert. Wir geben einen Überblick über die klinischen Manifestationen und fassen die diagnostischen Kriterien dieser Erkrankung zusammen.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0340-1855
    Keywords: Schlüsselwörter ; Chronische Polyarthritis ; Tumornekrosefaktorα ; Rezeptor-Fusionprotein ; TNFR-IgG ; Key words Rheumatoid arthritis ; tumor necrosis factorα ; receptor fusion protein ; TNFR-IgG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Aim of studies: To determine the optimal dose regimen for i.v. TNFR55-IgG1 in refractory rheumatoid arthritis. Methods: 218 patients with refractory rheumatoid arthritis were enrolled for two double-blind placebo-controlled multicenter trials (Europe and USA). They were treated with monthly i.v. placebo, 0.01, 0.05, 0.1 or 0.5mg/kg TNFR55-IgG1 after a 4 week wash-out of DMARDs. An additional German trial compared biweekly i.v. 20mg TNFR55-IgG1 and monthly 50mg following a loading does of 100mg in 60 patients. Results: TNFR55-IgG1 induced a substantial improvement already apparent one day after the first infusion. A maximal, dose dependent effect was reached after two weeks. Later, efficacy declined in parallel to an increase in anti-TNFR55-IgG1 antibodies resulting in an increased drug clearance. The drug was well tolerated with predominantly mild or moderate adverse events. Conclusion: Intravenous TNFR55-IgG1 was well tolerated and effective in refractory rheumatoid arthritis but the treatment schedules tested could not stabilise the initial improvement.
    Notes: Zusammenfassung Ziel der folgenden Studien war die Dosisoptimierung für eine Therapie der chronischen Polyarthritis mit TNFR55-IgG1 durch Erfassung der Wirksamkeit, Sicherheit, Verträglichkeit und Pharmakokinetik. Methode: In zwei doppelblinden, placebokontrollierten, multizentrischen Studien (Europa und USA) wurden insgesamt 218 Patienten mit refraktärer, florider chronischer Polyarthritis nach Auswaschen der Basistherapeutika bei gleichbleibender Dosis von NSAR und ggf. Steroiden mit monatlich i.v. Placebo, 0,01, 0,05, 0,2 oder 0,5mg/kg TNFR55-IgG1 behandelt. In einer weiteren deutschen Studie wurde eine Erhaltungstherapie von 14tätig 20mg TNFR55-IgG1 i.v. verglichen mit einer monatlichen Gabe von 50mg. Zuvor hatten die 60 Patienten in dieser Studie eine initale Dosis von 100mg erhalten. Ergebnis: In allen drei Studien zeigten Patienten, die mit TNFR55-IgG1 behandelt wurden, eine rasche und deutlische Besserung aller gemessenen Parameter bereits einen Tag nach der ersten Gabe. Das Maximum des therapeutischen Effektes war von der Dosis abhängig und wurde nach zwei Wochen erreicht. Nachfolgend kam es trotz der weiteren Gabe der Prüfsubstanz zu einem Anstieg der Entzündungsparameter. Parallel konnten anti-TNFR55-IgG1 Antikörper nachgewiesen werden, die die Clearance der Prüfsubstanz beschleunigten. Die Prüfsubstanz wurde in den drei Studien gut vertragen. Diskussion: Intravenöses TNFR55-IgG1 war rasch wirksam und gut verträglich bei Patienten mit „therapierefraktärer” chronischer Polyarthritis. Mit den geprüften Therapieschemata konnte aber die initial erreichte Besserung nicht aufrecht erhalten werden.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. 351-354 
    ISSN: 0340-1855
    Keywords: Schlüsselwörter ; Qualitätsmanagement ; Fortbildung ; Key words Quality management ; further education
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Since 1996, the curriculum „Quality management for physicians” exists with a three-level training concept. Based on these contents, a purposeful course program has been developed by the ZQ, and through May 1998 four level I-, four level II- and four level III-courses have been performed in Hannover. Thus, 50 physicians are qualified for new professional roles as hospital quality managers. The evaluation of a standardized questionnaire shows that the concept is highly accepted – meanwhile also by other professionals in health care. As a new model of quality assurance/quality evaluation is now developed for German hospitals, the contents of the training program will be updated for actual needs.
    Notes: Zusammenfassung Mit dem Curriculum „Ärztliches Qualitätsmanagement” liegt seit 1996 ein dreistufiges Fortbildungkonzept vor. Gemäß dem auf dieser Basis entwickelten zielorientierten Kursangebot wurden bisher im ZQ vier Grundkurse, vier Stufe-II-Kurse und vier Stufe-III-Kurse durchgeführt. Damit sind inzwischen 50 Ärzte/innen für neue Rollen als Qualitätsmanager im Krankenhaus qualifiziert. Die Ergebnisse der Teilnehmerbefragungen zeigen, daß das Konzept positiv bewertet wird – inzwischen auch von anderen Berufsgruppen im Gesundheitswesen. Nach nunmehr zweijähriger Erfahrung steht eine Aktualisierung der Inhalte bevor, insbesondere vor dem Hintergrund neuer anstehender Qualitätsdarlegungsmodelle für deutsche Krankenhäuser.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. 345-350 
    ISSN: 0340-1855
    Keywords: Schlüsselwörter ; Qualitätssicherung ; Qualitätsmanagement ; Patientenzufriedenheit ; Prozeßqualität ; Rehabilitation ; Key words Quality management ; process quality ; benchmarking ; patient satisfaction ; rehabilitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In the context of the quality assurance program of the German pension insurance institutions, instruments and procedures have been developed in the past few years in order to assess the quality of structure, process, and results of inpatient rehabilitation, as well as patient satisfaction. The routine implementation of these procedures aims at providing rehabilitation hospitals with fast information on shortcomings in their current practice, so that concepts of treatment and – in the long run – effects of rehabilitation can be systematically improved. When the „quality profiles” of rehabilitation hospitals are compared („benchmarking”), paying institutions of rehabilitation could gain information on the cost-quality-ratio of particular hospitals as well as important leads for improving the steering processes of patients and hospitals.  In the present article, results of a first „field-run” of the procedures for measuring patient satisfaction and quality of rehabilitation processes are reported. A comparative analysis of patient satisfaction in four orthopaedic/rheumatologic rehabilitation hospitals showed high degrees of overall satisfaction in all hospitals. In several subdimensions of patient satisfaction, however, significant differences between hospitals were found.  Quality of rehabilitation processes – as assessed by a standardized peer-review – varied substantially between 36 hospitals. Problems of quality were found especially in some dimensions that must be considered as crucial for rehabilitation, e.g., in the history and diagnosis of disabilities, in the consideration of psycho-social problems, or in the assessment of occupational capacities.
    Notes: Zusammenfassung Im Rahmen des Qualitätssicherungsprogramms der Rentenversicherungsträger wurden in den letzten Jahren Instrumente und Verfahren zur Erfassung der Struktur-, Prozeß- und Ergebnisqualität sowie der Patientenzufriedenheit erarbeitet. Durch den routinemäßigen Einsatz dieser Verfahren sollen den Kliniken zeitnah Informationen über etwaige Qualitätsprobleme („Schwachstellen”) zur Verfügung gestellt werden, die eine Weiterentwicklung der Behandlungskonzepte und damit letztlich bessere Rehabilitationsergebnisse ermöglichen sollen. Ein Vergleich der Qualitätsprofile von Rehabilitationseinrichtungen („benchmarking”) kann den Kostenträgern der Rehabilitationsmaßnahmen – neben wirtschaftlichen Gesichtspunkten (Pflegesatz) – außerdem wichtige Hinweise für die Zuweisungs- und Belegungssteuerung liefern. In der vorliegenden Arbeit werden Ergebnisse aus einem ersten Einsatz der Verfahren zur Messung von Patientenzufriedenheit und zur standardisierten Beurteilung der Prozeßqualität vorgestellt.  Bei einer vergleichenden Analyse der Patientenzufriedenheit in vier Rehabilitationskliniken mit orthopädisch/rheumatologischem Schwerpunkt fanden wir insgesamt eine hohe Zufriedenheit mit den Rehabilitationsmaßnahmen. In einigen Bereichen der Zufriedenheit ergaben sich zwischen den Kliniken jedoch signifikante Unterschiede.  Die Prozeßqualität, beurteilt durch ein Peer-Review-Verfahren, variiert zwischen 36 untersuchten Kliniken erheblich. Qualitätsprobleme fanden sich insbesondere in einigen für die Rehabilitation zentralen Dimensionen, so z.B. bei der Anamnese und Diagnostik von Fähigkeits- und Funktionsstörungen, bei der Berücksichtigung psychosozialer Belastungen und bei der sozialmedizinischen Stellungnahme.
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  • 7
    ISSN: 0340-1855
    Keywords: Schlüsselwörter ; Knorpelmatrixstruktur ; Enzyme ; Knorpelmarker ; Aggrecan-Fragmente ; Keratansulfat ; Chondroitinsulfat ; Hyaluronsäure ; Prokollagen ; crosslinks ; COMP ; Key words ; Extracellular cartilage matrix ; enzymes ; cartilage markers ; aggrecan ; hyaluronan ; keratan sulphat ; chondroitin sulphate ; procollagen ; crosslinks ; COMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The human cartilage and bone is characterized by a remodeling during the life, well balanced by neosynthesis and degradation of matrix components. In different joint diseases, it becomes imbalanced and the destruction of the cartilage supersedes the repair. In tissue processes in disease and in normal turnover of the matrix, these molecules are fragmented and released into surrounding fluids, in the synovial fluid, and then in the blood and the urin, where they can be detected. The quantitative measurement in the synovial fluid is more specific than in the other body fluids.  The research process in recent years has suggested that these molecular markers of cartilage and bone matrix metabolism can be used to determine diagnosis, the disease severity rather than its presence or absence, the prognosis, and the response to therapy. They should help to identify the disease mechanism in different joint diseases not only on the tissue but also on the molecular level. The specific cartilage matrix markers promise to become useful tools in the future in clinical use. The research in this area is still in the early stages, with most results dated from the end of the 1980s and the 1990s.
    Notes: Zusammenfassung Während des Lebens unterziehen sich Knorpel und Knochen in Anpassung an sich verändernde Belastungsbedingungen einem „Remodelling“, welches normalerweise ein physiologisches Gleichgewicht zwischen Abbau und Neusynthese von Matrixkomponenten darstellt. Bei differenten Gelenkerkrankungen ist dieses Gleichgewicht zugunsten der Destruktion verschoben. Beim normalen „turnover“ und gesteigert unter pathologischen Gelenkverhältnissen können intakte und framentierte Matrixbestandteile in die Synovialflüssigkeit, in das Blut und den Urin austreten und dort nachgewiesen werden. Eine Messung von Markern in der Synovia hat eine höhere Gelenkspezifität, während Serum-, Plasma- oder Urinmessungen eher den systemischen Stoffwechsel reflektieren. Der Forschungsprozeß der letzten Jahre hat die Hoffnung bestärkt, eventuell durch kombinierte Messungen mehrerer biochemischer Marker der Synthese und Destruktion des Knorpels und Knochens einen frühen diagnostischen Zugang, eine vermehrte prognostische Aussagefähigkeit und eine Hilfe in der Therapiekontrolle zu erhalten. Durch diese Markerstudien kann ein Beitrag zum besseren Verständnis des Knorpelmetabolismus und des Krankheitsmechanismus auf dem Gewebs- und Zellniveau geleistet werden. Es besteht die Notwendigkeit einer intensiven Forschung auf dem Gebiet der biochemischen Markersuche zur Nutzung im Bereich der Frühdiagnostik, der Verlaufsbeurteilung, der Kontrolle der Entzündungsaktivität sowie der Therapie- und Rehabilitationseffizienz bei degenerativen, traumatischen und entzündlichen Gelenkerkrankungen, woran weltweit gearbeitet wird. Mit der Anwendung von biochemischen Markern würde besonders die klinische Prüfung verschiedener Therapieformen auf eine solidere Basis gestellt.  Die gewebsspezifischen Marker des Knorpelmetabolismus versprechen in Zukunft nützliche Werkzeuge in der klinischen Anwendung zu werden, mit weiteren Möglichkeiten für interessante Studien. Da die hauptsächlichen Publikationen zu diesem Themenkreis in das Ende der achtziger und in die neunziger Jahre datieren, kann behauptet werden, daß die Forschung noch am Beginn steht.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. S23 
    ISSN: 0340-1855
    Keywords: Key words Fibromyalgia pain ; descending antinociception ; dorsal horn neurons ; spinal cord block ; Schlüsselwörter ; Fibromyalgie-Schmerzen ; deszendierende Antinozizeption ; Hinterhornneurone ; Kälteblock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Hypothese wird diskutiert, daß Fibromyalgie-Schmerzen durch eine Dysfunktion des deszendierenden, antinozizeptiven Systems (mit)verursacht sind. Ergebnisse aus Tierexperimenten zeigen, daß eine Unterbrechung des Systems durch Kühlung des Rückenmarks folgende Wirkungen auf nozizeptive Hinterhornneurone hat: 1. Anstieg der Ruheaktivität, 2. Senkung der mechanischen Reizschwelle, und 3. verstärkte Antworten auf Schmerzreize. Die Wirkung der deszendierenden Antinozizeption auf die Reizeffekte von tiefen Nozizeptoren war stärker als die Wirkung auf die Effekte von Nozizeptoren der Haut. Falls ähnliche Effekte auch bei Patienten auftreten, ist zu erwarten, daß eine Störung der deszendierenden Antinozizeption folgende Symptomebewirkt: 1.Spontanschmerzen (Ruheaktivität), 2. Druckschmerzhaftigkeit (Senkung der Schwelle) und 3. Hyperalgesie (verstärkte Antworten auf Schmerzreize). Die Änderungen sollten vorwiegend Schmerzen aus tiefen Geweben betreffen, da die deszendierende Antinozizeption hauptsächlich auf Reizeffekte von tiefen Nozizeptoren wirkt.
    Notes: Summary The hypothesis is discussed that a dysfunction of the descending antinociceptive system may underly the pain of fibromyalgia. Data from animal experimentation show that an interruption of the system by spinal cord cooling leads to (1) increase in ongoing activity, (2) lowering in stimulation threshold, and (3) increase in response magnitude in nociceptive dorsal horn neurons. The influence of the descending system was stronger on the responses to input from deep nociceptors than to input from cutaneous nociceptors. If similar changes occur also in patients, an impairment of the tonicly active descending system should be followed by (1) spontaneous pain (ongoing activity), (2) tenderness (lowering in mechanical threshold), and (3) hyperalgesia (increased responses to noxious stimuli). These changes should affect mainly deep pain, because the antinociceptive system influences predominantly input from deep nociceptors.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. S8 
    ISSN: 0340-1855
    Keywords: Key words ; Antidromic vasodilatation ; axon reflex ; flare reaction ; plasma extravasation ; substance P ; calcitonin gene-related peptide ; galanin ; capsaicin ; fibromyalgia ; Schlüsselwörter ; Antidrome Vasodilatation ; Axonreflex ; Flarereaktion ; Plasmaextravasation ; Substanz P ; Calcitonin Gene-Related Peptide ; Galanin ; Capsaicin ; Fibromyalgie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung C-Faser Nozizeptoren haben neben ihrer afferenten auch lokale efferente Funktionen, wie Vasodilatation, Plasmaextravasation und die Modulation neuronaler Aktivität, die durch Freisetzung der Neuropeptide Substanz P, Neurokinin A und Calcitonin Gene-Related Peptide (CGRP) an der peripheren Endigung ausgelöst werden. In der Haut der Säugetiere (einschließlich Mensch) ist CGRP der wichtigste Mediator der Flarereaktion. Die Vasodilatation wird beim Schwein durch Aktivierung von spezifischen Hitzenozizeptoren induziert. Bei der Taube wird die antidrome Vasodilatation durch intrinsisch freigesetztes Galanin gehemmt. Plasmaextravasation kann beim Schwein in Hautblasen und mit der Mikrodialyse durch Histaminsuperfusion, nicht aber durch elektrische Stimulation und Capsaicin, ausgelöst werden. Die neurogene Komponente der Histaminantwort (64%) wird durch NK2-Rezeptoren vermittelt und kann durch CGRP moduliert werden. Die genannten Neuropeptide können zur Sensibilisierung und unter bestimmten Bedingungen zur Stimulation von Nozizeptoren führen. Die erhöhte Sensitivität der Flarereaktion bei Fibromyalgiepatienten deutet auf eine veränderte Funktion der C-Faser Nozizeptoren hin.
    Notes: Summary C-fiber nociceptors not only serve afferent but also local efferent functions. The local efferent functions, such as vasodilatation, axon reflex flare reaction, plasma extravasation, and modulation of neuronal activity, are mediated via a local release of substance P, neurokinin A, and calcitonin gene-related peptide (CGRP) from the peripheral ending. CGRP is the main mediator of the capsaicin-induced flare reaction in the mammalian skin (including humans). In the pig skin the vasodilatation is due to activation of specific heat nociceptors. In the pigeon, antidromic vasodilatation is markedly inhibited by intrinsic galanin. Plasma extravasation in the pig skin blister base or using microdialysis can be evoked by histamine, but not by electrical stimulation or capsaicin. The neurogenic component of the histamine response (64%) appears to be mediated via NK2 receptors and can be modulated by CGRP. There is some evidence that the neuropeptides can also sensitize or stimulate nociceptors. Since in the fibromyalgia syndrome an increased sensitivity of the flare reaction has been observed, the hyperalgesia might be partly due to altered functions of C-fiber nociceptors.
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  • 10
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    Zeitschrift für Rheumatologie 57 (1998), S. S19 
    ISSN: 0340-1855
    Keywords: Key words ; Fibromyalgia syndrome ; laser evoked potentials ; auditory evoked potentials ; hyperalgesia ; hypervigilance ; attention ; Schlüsselwörter ; Fibromyalgie Syndrom ; Laser evozierte Potentiale ; akustisch evozierte Potentiale ; Hyperalgesie ; Hypervigilanz ; Aufmerksamkeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die bisherige Forschung zu dem Phänomen erhöhter Schmerzempfindlichkeit beim Fibromyalgie Syndrom (FS) ergab Hinweise sowohl für eine erhöhte Schmerzstärke nach nozizeptiven Reizen (Hyperalgesie) als auch für eine generelle Verstärkung sensorischer Wahrnehmungen (Hypervigilanz). Um zwischen diesen beiden Aspekten gestörter sensorischer Verarbeitung zu unterscheiden, wurden zerebral evozierte Potentiale nach kurzen, schmerzhaften Laser- und auditiven Reizen bei 10 FS-Patienten registriert. Die Ergebnisse wurden mit denen von gleichaltrigen schmerzfreien Kontrollpatienten verglichen. Die Amplituden der Komponenten mittlerer (N1) und später (P2) Latenz aus den Laser evozierten Potentialen (LEP) waren bei FS-Patienten signifikant größer als in den Kontrollen. Auch die Laser-Schmerzschwelle, nicht aber die Empfindungsschwelle, waren bei FS-Patienten gegenüber der Kontrollgruppe erniedrigt. Im Gegensatz hierzu unterschieden sich die akustisch evozierten Potentiale zwischen den beiden Studiengruppen nicht. Die vergrößerten N1- und P2-Amplituden der LEP deuten auf eine verstärkte sensorische und aufmerksamkeitsabhängige Verarbeitung nozizeptiver Information bei FS hin. Das Fehlen von Unterschieden nach auditiven Reizen stellt das Konzept der Hypervigilanz in Frage. Allerdings wird die Bedeutsamkeit unangenehmer Intensitäten auditiver Reize, die in dieser Studie nicht verwendet wurden, als Voraussetzung diskutiert, um übermäßige perzeptive Reaktionen auch durch nicht-nozizeptive Reize bei FS auslösen zu können.
    Notes: Summary Past research on the phenomenon of enhanced pain sensitivity in fibromyalgia syndome (FS) revealed evidence for both a higher pain magnitude in response to nociceptive stimuli (hyperalgesia) and a general perceptual amplification of sensations (hypervigilance). In order to distinguish between these two aspects of disturbed sensory processing in FS, cerebral evoked potentials after brief painful laser and auditory stimuli were measured in 10 FS patients. Results were compared with those from age-matched painfree controls. Amplitudes of middle-latency (N1) and long-latency (P2) laser evoked potentials (LEPs) were significantly higher in FS than in controls. Furthermore, laser intensity at pain but not at sensation threshold was lower in FS than in controls. However, auditory evoked potentials (AEPs) did not differ between groups. Enhanced N1 and P2 amplitudes of LEPs suggest stronger sensory and attentional processing of nociceptive information in FS, respectively. The concept of hypervigilance is challenged by the failure to find differences in auditory perception among FS and control patients. Yet, the importance of unpleasant intensities of auditory stimulation, not applied in this study, to reveal abnormal non-nociceptive perceptual amplification in FS is discussed.
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  • 11
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    Zeitschrift für Rheumatologie 57 (1998), S. S27 
    ISSN: 0340-1855
    Keywords: Key words ; Akinetic movement disorder ; Parkinson ; fibromyalgia ; basal ganglia ; cell death ; Schlüsselwörter ; Akinetische Bewegungsstörungen ; Parkinson ; Fibromyalgie ; Basalganglien ; Zelltod
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Patienten mit Fribromyalgie leiden manchmal unter sensiblen und Bewegungsstörungen, die eine gewisse Ähnlichkeit mit denjenigen bei akinetischen Syndromen aufweisen. Die Akinesie wird durch Funktionsstörungen in dem kortiko-thalamo-nigro-striatalen System und assoziierte Areale verursacht. Der Grund für diese Störung liegt bei der Parkinsonschen Krankheit in der verminderten Anzahl dopaminerger Neuronen in der Substantia nigra, pars compacta. Veränderungen anderer Neurotransmitter, wie GABA oder Serotonin, sowie in den Neurotransmitterreceptoren, sekundären Botenstoffen, und sekundären Modulierungen nach medikamentöser Behandlung treten auch auf. Die Ätiologie der nigralen Dysfunktion ist nur in seltenen Fällen bekannt. Toxische Substanzen und Mutationen gewisser Gene sind bekannte Beispiele in der Ätiologie von Bewegungsstörungen im Allgemeinen. In anderen akinetischen Syndromen, wie die Multisystemaffektion, die kortikobasale ganglionäre Degeneration und die progressive supranukleare Lähmung, wurde ein komplexerer Befall weitere Hirnareale festgestellt. Diese pathologisch-anatomischen Veränderungen haben typische klinische Folgerungen, die mittels Bildgebung und physiologischen Messungen in vivo untersucht werden können. Da die Basalganglien zudem eine Rolle in der Schmerzwahrnehmung spielen, erscheint eine vergleichende Untersuchung ihrer Störungen bei Nozizeption (inklusive Fibromyalgie) und bei Bewegungsstörungen vielversprechend, vor allem wenn es dann darum geht, neue, rationalere Therapiemodalitäten zu finden.
    Notes: Summary Patients with fibromyalgia sometimes have sign of a movement disorder in addition to sensory disturbances sometimes similar as those found in akinetic syndromes. Akinesia is due to disturbances in the functions of the cortico-thalamo-nigro-striatal system and associated areas. The reason of this dysfunction in Parkinson’s disease is a decreased nigral dopaminergic efferent innervation due to a neuronal degeneration in the pars compacta of the substantia nigra. Changes in other neurotransmitters, like GABA or serotonin, and in receptors and second messengers also occur, with additional modulation due to therapy. The aetiology of nigral malfunction is in only rarely known. Drugs and mutations of some genes are examples which give much insight in the pathogenesis of movement disorders in general. In other akinetic disorders, like multisystem atrophy, corticobasal ganglionic degeneration, and progressive supranuclear palsy, more complex patterns of degeneration have been found. This pathological anatomical disturbances have typical clinical effects which can be studied physiologically and with imaging in vivo. Since basal ganglia play also a role in pain, a comparative study of their involvement in movement disorders and nociception seems to be fruitful, especially in devising new therapeutic strategies.
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  • 12
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    Zeitschrift für Rheumatologie 57 (1998), S. S31 
    ISSN: 0340-1855
    Keywords: Key words ; Fibromyalgia syndrome ; nosology ; person-centered analyses ; biopsychosocial mechanisms ; course management ; Schlüsselwörter ; Fibromyalgie Syndrom ; Nosologie ; Personenzentrierte Dynamik ; Biopsychosoziale Mechanismen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Chronische großflächige Schmerzen im muskuloskelettalen System werden seit der Antike berichtet. Die kritische klinische und experimentelle Forschung zu diesem Thema wurde jedoch erst in den letzten ein bis zwei Jahrzehnten intensiviert. Bezüglich vielfältiger Aspekte dieses Problems existieren kontroverse Vorstellungen: Klassifikation und Nosologie, kausale Mechanismen, Verläufe und Folgen sowie therapeutische Strategien. Das Fibromyalgie Syndrom (FMS) ist keine Krankheit im herkömmlichen Sinne, sondern als eine funktionelle Störung anzusehen. Verschiedene typische Ausprägungen als auch disponierende Faktoren wurden bislang identifiziert. Unter diesen Gesichtspunkten ist für das Verständnis der komplexen multifaktoriellen Wechselwirkungen beim FMS eher ein neues biopsychosoziales Paradigma der personenbezogenen Dynamik erforderlich als die Suche nach einem spezifischen Agens oder Umweltfaktoren. Konzeptionelle Modelle zu Ätiologie und Forschungsmethoden sind bisland nur unzureichend entwickelt, um solche komplexen, multifaktoriellen Mechanismen zu untersuchen. Neue Wege der Forschung lassen verbesserte Behandlungsmethoden für FMS-Patienten erwarten.
    Notes: Summary Chronic widespread musculoskeletal pains have been recorded since antiquity. However, critical medical and experimental research on these conditions have been performed mainly within the past one or two decades. Controversy exists regarding many aspects of these common problems, including: classification and nosology; causation mechanisms; course and outcomes, as well as management strategies. Fibromyalgia syndrome (FMS) is not a disease. Neither a defined pathology nor specific etiological mechanisms have been documented. Instead, FMS may be considered a dysfunctional disorder. Constellations of typical, although diverse, manifestations have been identified as well as predisposing factors. Under such circumstances, a new biopsychosocial paradigm of person-centered dynamics, rather than an agent per se or the environment, is fundamental to understanding the complex multifactorial interactions in FMS. Conceptual models of etiology and research methodology to investigate such complex, multifactorial mechanisms are not yet well-developed. More effective research approaches and improved management of persons with FMS is expected to result from such new conceptual constructs.
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  • 13
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    Zeitschrift für Rheumatologie 57 (1998), S. S61 
    ISSN: 0340-1855
    Keywords: Key words ; Fibromyalgia syndrome ; genetic factors ; HLA system ; Schlüsselwörter ; Fibromyalgie Syndrom ; genetische Faktoren ; HLA-System
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Obwohl die familiäre Häufung des Fibromyalgie Syndroms (FMS) schon mehrfach beschrieben wurde, finden sich bislang nur wenige genetische Untersuchungen zu diesem Thema. So haben einige wenige Studien diese familiäre Häufung zusammen mit einer Assoziation im HLA System berichtet. Unsere eigene Forschungsgruppe hat aktuell in einer Studie die Verbindung von Fibromyalgie Syndrom und HLA System in Familien mit mehrfach an FMS Erkrankten untersucht.
    Notes: Summary Although familial occurrence of fibromyalgia syndrome (FMS) has been commonly observed, data on a genetic role in this condition are limited. A few studies have reported familial aggregation and association with HLA. We have studied genetic linkage of FMS with HLA in multicase families, and found a rather weak linkage of FMS with HLA (P〈0.029).
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  • 14
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    Journal of orofacial orthopedics 59 (1998), S. 127-138 
    ISSN: 1615-6714
    Keywords: Cephalometric analysis ; Class II malocclusion ; Magnets ; Straight-wire appliance ; Superelastic coils ; Schlüsselwörter ; Kephalometrie ; Klasse-II-Bißanomalie ; Magneten ; Straight-wire-Apparatur ; Superelastische Federn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden 18 fortlaufend ausgewählte Patienten (bei Behandlungsbeginn durchschnittlich 14,7 Jahre alt) mit dentaler Klasse II, Tiefbiß und Platzmangel im oberen Zahnbogen untersucht. Während der ersten sechsmonatigen Behandlungsphase erfolgte die Distalisierung der ersten und zweiten oberen Molaren mittels sich abstoßender Samarium-Cobalt-Magneten auf der einen und superelastischer Nickel-Titan-Federn auf der kontralateralen Seite bei zur Bißöffnung eingesetzter frontaler Aufbißplatte. Die zweite Behandlungsphase von durchschnittlich 1,3 Jahren wurde mit einer Straightwire-Apparatur durchgeführt. Fernröntgenseitenbilder und Gipsmodelle wurden zu Behandlungsbeginn, nach der Molarendistalisierung, am Ende der aktiven Behandlung und ein Jahr nach Behandlungsabschluß angefertigt. Die Behandlung führte hauptsächlich zu dentalen Veränderungen. Die dentale Klasse II wurde durch körperliche Distalbewegung der oberen und Mesialbewegung der unteren Molaren in eine Klasse I korrigiert. Die Korrektur der Molarenrelation war auf der mit Federn behandelten Seite signifikant größer als auf der mit Magneten behandelten (durchschnittlich 3,4 mm gegenüber 3,0 mm). Trotz des Verankerungsverlustes während der Molarendistalisierung in Form einer Protrusion der oberen Schneidezähne um durchschnittlich 1,8 mm wurde der Netto-Overjet durch Klasse-II-Gummizüge durchschnittlich um 2,5 mm verringert. Die durchschnittliche Bißerhöhung um 2,6 mm war vorwiegend auf die Extrusion der Molaren zurückzuführen. Während der einjährigen Beobachtungszeit nach Abschluß der aktiven Behandlung wurden keine signifikanten dentalen oder skelettalen Veränderungen gefunden. Die Langzeitstabilität der Behandlungsergebnisse bedarf weiterer Untersuchungen.
    Notes: Abstract The investigation comprised 18 consectuvely selected patients, mean age 14.7 years at the start of treatment, with Class II malocclusion, deep overbite and space deficiency in the maxillary arch. The first phase of the treatment consisted of 6 months simultaneous distal movement of maxillary first and second molars with repelling samarium-cobalt magnets on one side and a superelastic nickel-titanium coil on the contralateral side together with an anterior biteplane to achieve bite opening. For the second phase of the treatment, a straight-wire appliance was used for an average treatment time of 1.3 years. Lateral head radiographs and dental casts were available at the start of treatment, after molar distalisation, at the end of treatment and 1 year post-treatment. The treatment resulted mainly in dental changes. The dental Class II molar relation was corrected to Class I by bodily distal movement of maxillary molars and by mesial movement of the mandibular molars. The correction of molar relation was significantly greater on coil sides than on magnet sides, mean 3.4 mm, and 3.0 mm, respectively. Despite anchorage loss associated with the maxillary molar movement, i. e. mesial movement of the maxillary incisors (mean 1.8 mm), the net overjet was reduced, mean 2.5 mm, by the use of Class II elastics. The average net improvement of bite opening was 2.6 mm, mainly due to extrusion of mandibular and maxillary molars. During the 1-year post-treatment period no significant dental or skeletal changes were found. The long-term implications of the treatment results need further consideration.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1-24 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We study the large time asymptotics of solutions u(x, t) of the wave equation with time-harmonic force density f(x)e-iωt, ω≥0, in the semi-strip Ω= (0, ∞)×(0, 1) for a given f∊C∞0(Ω). We assume that u satisfies the initial condition u=(∂/∂t)u=0 for t=0 and the boundary conditions u=0 for x2=0 and x2=1, and (∂/∂x1)u=αu for x1=0, with given α, -π≤α〈∞. Let Dα be the self-adjoint realization of -Δ in Ω with this boundary condition. For -π≤α〈0, Dα has eigenvalues λj=π2j2-α2, j=1, 2, … For j≥2 these eigenvalues are embedded in the continuous spectrum of Dα, σc(Dα)=[π2, ∞]. For α≥0, Dα has no eigenvalues. We consider the asymptotic behaviour of u(x, t), t→∞, as a function of α. In the case α=0 resonances of order √t at ω=πj, j=1, 2, …, were found in References 5 and 10. We prove that for α=-π there is a resonance of order t2 for ω=0 and resonances of order t for every ω〉0 (note that 0 is an eigenvalue of D-π). Moreover, for -π〈α〈0 there are resonances of order t at ω=√λj. The resonance frequencies are continuous functions of α for -π〈α〈0 and tend to πj, j=1, 2, … as α goes to zero.On the contrary in the case α〉0 there are no real resonances in the sense that the solution remains bounded in time as t→∞. Actually in this case, the limit amplitude principle is valid for all frequencies ω≥0. This rather striking behaviour of the resonances is explained in terms of the extension of the resolvent R(κ)=(Dα-κ2)-1 as a meromorphic function of κ into an appropriate Riemann surface. We find that as α crosses zero the real poles of R(κ) associated with the eigenvalues remain real, but go into a second sheet of the Riemann surface. This behaviour under perturbation is rather different from the case of complex resonances which has been extensively studied in the theory of many-body Schrödinger operators where the (real) eigenvalues embedded in the continuous spectrum turn under a small perturbation into complex poles of the meromorphic extension of the resolvent, as a function of the spectral parameter κ2. © 1998 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 16
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 117-128 
    ISSN: 0170-4214
    Keywords: third-grade fluid ; existence ; uniqueness ; classical solution ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The global existence and uniqueness of classical solution of steady motions of a third-grade fluid provided assumptions on positivness of μ (coefficient of viscosity) and α1, γ (material coefficients) is proved. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 17
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 227-249 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Integral equations associated with the basic boundary value problems for the Laplace and Stokes equations are considered. The integral operators for these integral equations are interpreted as the pseudodifferential operators, and their principal symbols are calculated. The symbols are obtained in terms of the principal curvatures and the coefficients of the first quadratic form of the boundary. As a consequence, the initial approximation is suggested for the iterative methods solving the integral equations. © 1998 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 18
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 327-359 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The boundary integral equation method is used to prove the convergence of the Drude-Born-Fedorov equations with variable coefficients, possibly non-smooth, to Maxwell's equations as chirality admittance tends to zero. © 1998 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 19
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 565-588 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: New explicit stability conditions are derived for a linear integro-differential equation with periodic operator coefficients. The equation under consideration describes oscillations of thin-walled viscoelastic structural members driven by periodic loads. To develop stability conditions two approaches are combined. The first is based on the direct Lyapunov method of constructing stability functionals. It allows stability conditions to be derived for unbounded operator coefficients, but fails to correctly predict the critical loads for high-frequency excitations. The other approach is based on transforming the equation under consideration in such a way that an appropriate ‘differential’ part of the new equation would possess some reserve of stability. Stability conditions for the transformed equation are obtained by using a technique of integral estimates. This method provides acceptable estimates of the critical forces for periodic loads, but can be applied to equations with bounded coefficients only. Combining these two approaches, we derive explicit stability conditions which are close to the Floquet criterion when the integral term vanishes. These conditions are applied to the stability problem for a viscoelastic bar compressed by periodic forces. The effect of material and structural parameters on the critical load is studied numerically. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 20
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 653-664 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In order to maintain spectrally accurate solutions, the grids on which a non-linear physical problem is to be solved must also be obtained by spectrally accurate techniques. The purpose of this paper is to describe a pseudospectral computational method of solving integro-differential systems with quadratic performance index. The proposed method is based on the idea of relating grid points to the structure of orthogonal interpolating polynomials. The optimal control and the trajectory are approximated by the m th degree interpolating polynomial. This interpolating polynomial is spectrally constructed using Legendre-Gauss-Lobatto grid points as the collocation points, and Lagrange polynomials as trial functions. The integrals involved in the formulation of the problem are calculated by Gauss-Lobatto integration rule, thereby reducing the problem to a mathematical programming one to which existing well-developed algorithms may be applied. The method is easy to implement and yields very accurate results. An illustrative example is included to confirm the convergence of the pseudospectral Legendre method, and a comparison is made with an existing result in the literature. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 21
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 701-718 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This article establishes the existence of a trapped-mode solution to a linearized water-wave problem. The fluid occupies a symmetric horizontal channel that is uniform everywhere apart from a confined region which either contains a thin vertical plate spanning the depth of the channel or has indentations in the channel walls; the forces of gravity and surface tension are operative. A trapped mode corresponds to an eigenvalue of the composition of an inverse differential operator and a Neumann-Dirichlet operator for an elliptic boundary-value problem in the fluid domain. The existence of such an eigenvalue is established by extending previous results dealing with the case when surface tension is absent. © 1998 B.G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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  • 22
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 501-517 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper an initial-boundary-value problem in one-space dimension is studied for the Broadwell model extended to a gas mixture undergoing bimolecular reactions. Techniques of semigroup of bounded positive operators in a suitable Banach space are used to prove existence and uniqueness of the solution on bounded time intervals whose length depends on the initial data. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 23
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 685-700 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In the present work, the problem of electromagnetic wave propagation in three-dimensional stratified media is studied. The method of decoupling the electric and magnetic fields is implemented, and the spectral approach is adopted, componentwise, to the vector equation involving the electric field. Operational calculus of self-adjoint, positive operators in suitable Hilbert spaces is used to solve the corresponding initial value problems. The spectral families of these operators for the cases of the whole space and of a finite layer are constructed. A discussion on the applicability of the obtained results to physical problems is also included. © 1998 B.G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 24
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 757-780 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper we prove under the assumption of small initial data the global existence of a classical solution to the equations in viscoelasticity, associated with a free damping boundary condition. We also show that if we choose the initial data large enough, blow up will occur in finite time. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 25
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 797-821 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider the thermoelastic plate system,utt-γΔutt+Δ2u+αΔθ=0,θt-κΔθ-αΔut=0 and we make a comparison between the models in which γ=0 and γ〉0. We conclude that in the first case the plate system is of a parabolic type, while when γ〉0 the corresponding system has a hyperbolic behaviour. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 26
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 883-894 
    ISSN: 0170-4214
    Keywords: solitary wave ; stability ; long wave-short wave resonance equations ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This paper concerns the orbital stability for solitary waves of the Long Wave-Short Wave resonance equations. Since the abstract results of Grillakis et al. [7, 8] cannot be applied directly, we can extend the abstract stability theory and use the detailed spectral analysis to obtain the stability of the solitary waves. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 27
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1049-1066 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider particle transport in a three-dimensional convex region V, bounded by the regular surface ∂V. We assume that particles are specularly reflected by ∂V and that a source q is assigned on ∂V; more general non-homogeneous boundary conditions are also discussed. The problem is non-linear because the boundary condition is not homogeneous. We prove existence of a unique strict solution and by using the theory of semigroups we derive the explicit expression of such a solution in terms of the boundary source q. In the appendix, we indicate how some properties of affine operators can be used to derive the solution. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 28
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1085-1105 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: A phase-field model based on the Coleman-Gurtin heat flux law is considered. The resulting system of non-linear parabolic equations, associated with a set of initial and Neumann boundary conditions, is studied. Existence, uniqueness, and regularity results are proved. An asymptotic analysis is also carried out, in the case where the coefficient of the interfacial energy term tends to 0. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 29
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1115-1148 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We apply the Child-Langmuir asymptotics of the Vlasov-Poisson system to the case of a bipolar diode, i.e. a vacuum diode where two species of particles of opposite electric charge are flowing. This leads to a simplified model which, if at least one of the two injected currents is not too large, has a unique solution. Moreover, in that case, the currents flowing inside the diode are limited by the so-called bipolar Child-Langmuir currents. In the case of large currents, other solutions may appear, and the formation of virtual electrodes may occur inside the diode. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 30
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1107-1113 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper we consider the Cauchy problem for the equation∂u/∂t + u ∂u/∂x + u/x = 0 for x 〉 0, t ≥ 0, with u(x, 0) = u0-(x) for x 〈 x0, u(x, 0) = u0+(x) for x 〉 x0, u0-(x0) 〉 u0+(x0). Following the ideas of Majda, 1984 and Lax, 1973, we construct, for smooth u0- and u0+, a global shock front weak solution u(x, t) = u-(x, t) for x 〈 φ(t), u(x, t) = u+(x, t) for x 〉 φ(t), where u- and u+ are the strong solutions corresponding (respectively) to u0- and u0+ and the curve t → φ(t) is defined by dφ/dt (t) = 1/2[u-(φ(t), t) + u+(φ(t), t)], t ≥ 0 and φ(0) = x0.© 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 31
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1195-1206 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: A variational approach to a non-linear non-local identification problem related to the non-linear transport equation is studied. Introducing a similarity transformation, the problem is formulated as an identification problem for a non-linear differential equation of second order with an additional non-local condition. For the solution of the forward problem stability in H1-norm with respect to the identification parameter is obtained. Using this result the existence of a solution to the identification problem is proved. Some results of computational experiments are given. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 32
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1233-1267 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider the plate equation in a polygonal domain with free edges. Its resolution by boundary integral equations is considered with double layer potentials whose variational formulation was given in Reference 25. We approximate its solution (u, (∂u/∂n)) by the Galerkin method with approximated spaces made of piecewise polynomials of order 2 and 1 for, respectively, u and (∂u/∂n). A prewavelet basis of these subspaces is built and equivalences between some Sobolev norms and discrete ones are established in the spirit of References 14, 16, 30 and 31. Further, a compression procedure is presented which reduces the number of nonzero entries of the stiffness matrix from O(N2) to O(N log N), where N is the size of this matrix. We finally show that the compressed stiffness matrices have a condition number uniformly bounded with respect to N and that the compressed Galerkin scheme converges with the same rate than the Galerkin one. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 33
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1287-1296 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The relativistic Vlasov-Maxwell-Fokker-Planck system is used in modelling distribution of charged particles in plasma. It consists of a transport equation coupled with the Maxwell system. The diffusion term in the equation models the collisions among particles, whereas the viscosity term signifies the dynamical frictional forces between the particles and the background reservoir. In the case of one space variable and two momentum variables, we prove the existence of a classical solution when the initial density decays fast enough with respect to the momentum variables. The solution which shares this same decay condition along with its first derivatives in the momentum variables is unique. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 34
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1415-1439 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider reactive mixtures of dilute polyatomic gases in full vibrational non-equilibrium. The governing equations are derived from the kinetic theory and possesses an entropy. We recast this system of conservation laws into a symmetric conservative form by using entropic variables. Following a formalism developed by the authors in a previous paper, the system is then rewritten into a normal form, that is, in the form of a quasilinear symmetric hyperbolic-parabolic system. Using a result of Vol'pert and Hudjaev, we prove local existence and uniqueness of a bounded smooth solution to the Cauchy problem. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 35
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1479-1494 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Approximate solutions of the non-linear Boltzmann equation, which have the structure of the linear combination of three global Maxwellians with arbitrary hydrodynamical parameters, are considered. Some sufficient conditions which allow the error between the left- and the right-hand sides of the equation tend to zero, and which are calculated either in the mixed metric or in the pure integral metric, are obtained. The class of the distributions, which minimized this error for the arbitrary Knudsen number, is found. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 36
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1519-1542 
    ISSN: 0170-4214
    Keywords: non-hyperbolic systems ; two-phase flows ; dispersion terms ; symmetrization ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The paper considers a system of partial differential equations of convection dispersion type, modelling a stratified two-phase fluid flow. Local existence in time is proved for a sufficiently smooth initial data, given in the set of physically admissible states. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 37
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1559-1569 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper we study the motion of an elastic conducting wire in a magnetic field. The motion of the conductor induces a current in the wire (Faraday's law) which, in turn produces a force on the wire. We consider the linear equation obtained by linearizing the resulting equations of motion about an equilibrium solution. This is a hyperbolic partial differential equation with a non-local term. We prove existence and uniqueness of a weak solution of an initial-boundary value problem for this equation. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 38
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1637-1654 
    ISSN: 0170-4214
    Keywords: generalized Stokes equations ; incompressible flow ; least-squares ; finite element method ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper we are concerned with a weighted least-squares finite element method for approximating the solution of boundary value problems for 2-D viscous incompressible flows. We consider the generalized Stokes equations with velocity boundary conditions. Introducing the auxiliary variables (stresses) of the velocity gradients and combining the divergence free condition with some compatibility conditions, we can recast the original second-order problem as a Petrovski-type first-order elliptic system (called velocity-stress-pressure formulation) in six equations and six unknowns together with Riemann-Hilbert-type boundary conditions. A weighted least-squares finite element method is proposed for solving this extended first-order problem. The finite element approximations are defined to be the minimizers of a weighted least-squares functional over the finite element subspaces of the H1 product space. With many advantageous features, the analysis also shows that, under suitable assumptions, the method achieves optimal order of convergence both in the L2-norm and in the H1-norm. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 39
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1619-1635 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider the two-parameter non-linear Sturm-Liouville problems. By using the variational method on general level sets, the variational eigenvalues are obtained. The purpose of this paper is to study the properties of these variational eigenvalues with respect to the parameter of general level sets. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 40
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 187-226 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We study the limit behaviour of solution of Poisson's equation in a class of thin two-dimensional domains, both simply connected or single-hollowed, as its thickness becomes very small. The method is based on a transformation of the original problem into another posed on a fixed domain, obtention of a priori estimates and convergence results when thickness parameter tends to zero. As an important application of abstract results we obtain the limit expressions for functions appearing in elastic beam theories as torsion and warping functions. In this way, we provide a mathematical justification and a correct definition of torsion, warping and Timoshenko functions and constants that should be used in the open and closed thin-walled elastic beam theories. © 1998 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 41
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 269-279 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The generalized Möbius function and Möbius inversion formula are applied to a multiplicative semigroup. A general mathematical method based on this Möbius inversion is presented to solve inversion problems of expansions with unequally weighted terms. By this method, all the inverse lattice problems in physics can be solved concisely. The solutions of four inverse lattice problems: the Fibonacci structure, the square lattice structure, the bcc and the hcp lattice structures are given. These are difficult to be solved by other methods. © 1998 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 42
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 361-374 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We use the eigenfunction expansion of Green's function of Dirichlet problems to obtain sampling theorems. The analytic properties of the sampled integral transforms as well as the uniform convergence of the sampling series are proved without any restrictions on the integral transforms. We obtain a one- and multi-dimensional versions of sampling theorems. In both cases the sampling series are written in terms of Lagrange-type interpolation expansions. Some examples and the truncation error as well as the stability of the obtained sampling expansions are discussed at the end of the paper. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 43
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 393-416 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider a dynamical von Kármán system in the presence of thermal effects. Our model includes the possibility of a rotational inertia term in the system. We show that the total energy of the solution of such system decays exponentially as t→+∞. The decay rates we obtain are uniform on bounded sets of the energy space. The main ingredients of our method of proof are suitable properties of a decoupled system, the energy method and the compactness of the nonlinear map associated to the von Kármán system. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 44
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 479-488 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This short article discusses the spectrum of the Neumann Laplacian in the infinite domain Ω⊂∝n, n ≥2 created by inserting a compact obstacle P into the uniform cylinder Ω0 =(-∞, ∞)×Ω′. The main result is the existence of at least one embedded eigenvalue when P is an (n -2)-dimensional surface whose unit normal is parallel to Ω′ at each point of P . The special case when P is symmetric about {0}×Ω′ is also treated. It is shown that there is at least one symmetric eigenvector and, when P is sufficiently long, at least one antisymmetric eigenvector. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 45
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 551-564 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We prove the existence of solutions to the three-dimensional elastoplastic problem with Hencky's law and Neumann boundary conditions by elliptic regularization and the penalty method, both for the case of a smooth boundary and of an interior two dimensional crack. It is shown, in particular, that the variational solution satisfies all boundary conditions. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 46
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 251-268 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The propagation of Hölder regularity of the solutions to the 3D Euler equations is discussed. Our method is a special semi-linearization of the vorticity equation combined with the classical Schauder interior estimates. © 1998 by B.G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 47
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 433-461 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This paper is concerned with the solution of Maxwell equations in the modelling of the scattering of a time-harmonic electromagnetic wave by an obstacle located in a two-layered medium. The use of the Silver-Müller radiation condition in each layer is shown to provide a well-posed scattering problem. The analysis is based on the study of the Green tensor, which allows to relate the radiation condition to an integral representation formula. The analyticity properties of the scattering problem with respect to the frequency are then investigated. This gives rise to a limiting absorption principle and furnishes a characterization of the resonances. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 48
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 489-499 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We apply our recently developed distributional technique [2, 3] to study time-domain asymptotics. This enables us to present a rigorous mathematical discussion and extensions of the results given by Chapman [1] and subsequent workers in this field. The present analysis is facilitated by defining functions which are distributionally small at infinity. We find that one of the advantages of using this technique is that multidimensional extensions can be derived very easily. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 49
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 519-549 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This paper is concerned with a specific finite element strategy for solving elliptic boundary value problems in domains with corners and edges. First, the anisotropic singular behaviour of the solution is described. Then the finite element method with anisotropic, graded meshes and piecewise linear shape functions is investigated for such problems; the schemes exhibit optimal convergence rates with decreasing mesh size. For the proof, new local interpolation error estimates for functions from anisotropically weighted spaces are derived. Finally, a numerical experiment is described, that shows a good agreement of the calculated approximation orders with the theoretically predicted ones. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 50
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 605-617 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This paper presents a general method of analysis for investigating the whirl stability of a rotor-bearing system whose appendage is flexibly attached to the spinning shaft. Sufficient conditions of asymptotic stability involving system different parameters are derived based on Liapunov's theory. An inclusive analysis of the effect of the combined flexibilities of the elastic attachment of the appendage to the shaft and the two end bearings coupled with the other various parameters of the system on the dynamic stability is presented. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 51
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 665-684 
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    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We investigate the steady compressible Navier-Stokes equations near the equilibrium state v = 0, ρ = ρ0 (v the velocity, ρ the density) corresponding to a large potential force. We introduce a method of decomposition for such equations: the velocity field v is split into a non-homogeneous incompressible part u (div (ρ0u) = (0) and a compressible (irrotational) part ∇φ. In such a way, the original complicated mixed elliptic-hyperbolic system is split into several ‘standard’ equations: a Stokes-type system for u, a Poisson-type equation for φ and a transport equation for the perturbation of the density σ = ρ - ρ0. For ρ0 = const. (zero potential forces), the method coincides with the decomposition of Novotny and Padula [21]. To underline the advantages of the present approach, we give, as an example, a ‘simple’ proof of the existence of isothermal flows in bounded domains with no-slip boundary conditions. The approach is applicable, with some modifications, to more complicated geometries and to more complicated boundary conditions as we will show in forthcoming papers. © 1998 B.G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 52
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 619-651 
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    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider acoustic scattering from an obstacle inside an inhomogeneous structure. We prove in the paper that if the outside inhomogeneity is known then the obstacle and possible inside inhomogeneity are uniquely determined by the fixed energy far field data. The proof is based on new mapping properties of layer potentials in spaces that specify one point. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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  • 53
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 939-967 
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    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The linear problem for the velocity potential around a slightly curved thin finite wing is considered under the Joukowskii-Kutta hypothesis. The exponents of possible singularities of solutions at angular points on wing's trailing edge are expressed in terms of eigenvalues of mixed boundary value problems for the Beltrami-Laplace operator on the hemisphere and the semicircle. These singularities have a structure such that the circulation function turns out to be continuous in interior angular points of the trailing edge. In the case of trapezoidal shape of the wing ends there occur square-root singularities of the velocity field at the trailing edge endpoints and the same singularities, of course, are extended along the lateral sides of the wake behind the wing. It is proved that for any angular point on the trailing edge the exponents of all above-mentioned singularities form a countable set in the upper complex half-plane with the only accumulation point at infinity. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 54
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 985-1014 
    ISSN: 0170-4214
    Keywords: Vlasov-Poisson-Fokker-Planck ; long-time behaviour ; fundamental solutions ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We study the long-time behaviour of solutions of the Vlasov-Poisson-Fokker-Planck equation for initial data small enough and satisfying some suitable integrability conditions. Our analysis relies on the study of the linearized problems with bounded potentials decaying fast enough for large times. We obtain global bounds in time for the fundamental solutions of such problems and their derivatives. This allows to get sharp bounds for the decay of the difference between the solutions of the Vlasov-Poisson-Fokker-Planck equation and the solution of the free equation with the same initial data. Thanks to these bounds, we get an explicit form for the second term in the asymptotic expansion of the solutions for large times. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1067-1084 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: An initial-value problem modelling coagulation and fragmentation processes is studied. The results of earlier papers are extended to models where either one or both of the rates of coagulation and fragmentation depend on time. An abstract integral equation, involving the solution operator to the linear fragmentation part, is investigated via the contraction mapping principle. A unique global, non-negative, mass-conserving solution to this abstract equation is shown to exist. The latter solution is used to generate a global, non-negative, mass-conserving solution to the original non-autonomous coagulation and multiple-fragmentation equation. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1185-1194 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper we prove the global existence and study decay property of the solutions to the initial boundary value problem for the quasi-linear wave equation with a dissipative term without the smallness of the initial data. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1207-1226 
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    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Reaction random-walk systems are hyperbolic models to describe spatial motion (in one dimension) with finite speed and reactions of particles. Here we present two approaches which relate reaction random-walk equations with reaction diffusion equations. First, we consider the case of high particle speeds (parabolic limit). This leads to a singular perturbation analysis of a semilinear damped wave equation. A initial layer estimate is given. Secondly, we consider the case of a transcritical bifurcation. We use techniques similar to that of the Ginzburg-Landau method to find a modulation equation for the amplitude of the first unstable mode. It turns out that the modulation equation is Fisher's equation, hence near the bifurcation point travelling wave solutions are obtained. The approximation result and the corresponding estimate is given in terms of the bifurcation parameter. Both results are based on an a priori estimate for classical solutions which follows from explicit representations of the solution of the linear telegraph equation. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1365-1377 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In the article the problem of regulation of the cardiovascular system is investigated from the point of view of control process theory. This problem was reduced to finding the optimal control in the sense of speed in a bilinear system. In the first part of the article the possibility of applying Saburov's method for the solution to bilinear control problems is considered. The second part of the article is devoted to the application of this method to a concrete problem from practical medicine. The method has allowed the complete synthesis of an optimal control to be carried out  -  the sliding mode takes place and it was investigated completely. The results obtained are interesting from the point of view of control process theory, and testify to the high efficiency of the method. The final results allow concrete recommendations about the regulation of the cardiovascular system. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1399-1413 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The steady-state equations for a charged gas or fluid consisting of several components, exposed to an electric field, are considered. These equations form a system of strongly coupled, quasilinear elliptic equations which in some situations can be derived from the Boltzmann equation. The model uses the duality between the thermodynamic fluxes and the thermodynamic forces. Physically motivated mixed Dirichlet-Neumann boundary conditions are prescribed. The existence of generalized solutions is proven. The key of the proof is a transformation of the problem by using the entropic variables, or electro-chemical potentials, which symmetrize the equations. The uniqueness of weak solutions is shown under the assumption that the boundary data are not far from the thermal equilibrium. A general uniqueness result cannot be expected for physical reasons. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1343-1363 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider an elastic plate with the non-deformed shape ΩΣ := Ω \ Σ, where Ω is a domain bounded by a smooth closed curve Γ and Σ ⊂ Ω is a curve with the end points {γ1, γ2}. If the force g is given on the part ΓN of Γ, the displacement u is fixed on ΓD := Γ \ ΓN and the body force f is given in Ω, then the displacement vector u(x) = (u1(x), u2(x)) has unbounded derivatives (stress singularities) near γk, k = 1, 2   u(x) = ∑2k, l=1 Kl(γk)r1/2kSCkl(θk) + uR(x)     near γk.Here (rk, θk) denote local curvilinear polar co-ordinates near γk, k = 1, 2, SCkl (θk) are smooth functions defined on [-π, π] and uR(x) ∊ {H2(near γk)}2. The constants Kl(γk),   l = 1, 2, which are called the stress intensity factors at γk (abbr. SIFs), are important parameters in fracture mechanics. We notice that the stress intensity factors Kl(γk) (l = 1, 2;  k = 1, 2) are functionals Kl(γk) = Kl(γk; L, Ω, Σ) depending on the load L, the shape of the plate Ω and the shape of the crack Σ. We say that the crack Σ is safe, if Kl(γk; Ω)2 + K2(γk; Ω)2 〈 RẼ. By a small change of Ω the shape Σ can change to a dangerous one, i.e. we have K1(γk; Ω)2 + K2(γk; Ω)2 ≥ RẼ. Therefore it is important to know how Kl(γk) depends on the shape of Ω.For this reason, we calculate the Gâteaux derivative of Kl(γk) under a class of domain perturbations which includes the approximation of domains by polygonal domains and the Hadamard's parametrization Γ(τ) := {x + τφ(x)n(x);  x ∊ Γ}, where φ is a function on Γ and n is the outward unit normal on Γ. The calculations are quite delicate because of the occurrence of additional stress singularities at the collision points {γ3, γ4} = ΓD ∩ ΓN.The result is derived by the combination of the weight function method and the Generalized J-integral technique (abbr. GJ-integral technique). The GJ-integrals have been proposed by the first author in order to express the variation of energy (energy release rate) by extension of a crack in a 3D-elastic body. This paper begins with the weak solution of the crack problem, the weight function representation of SIF's, GJ-integral technique and finish with the shape sensitivity analysis of SIF's. GJ-integral Jω(u; X) is the sum of the P-integral (line integral) Pω(u, X) and the R-integral (area integral) Rω(u, X). With the help of the GJ-integral technique we derive an R-integral expression for the shape derivative of the potential energy which is valid for all displacement fields u ∊ H1. Using the property that the GJ-integral vanishes for all regular fields u ∊ H2 we convert the R-integral expression for the shape derivative to a P-integral expression. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1543-1558 
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    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: It is shown that a stochastic system of N interacting particles in a slab approximates, in the Boltzmann-Grad limit, a one-dimensional Boltzmann equation with diffusive boundary conditions. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1571-1591 
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    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The asymptotic behaviour of solutions of certain semilinear elliptic Dirichlet boundary value problems defined on a semi-infinite cylinder is investigated by means of energy arguments and maximum principles. Various hypotheses are made on the form of the semilinear term, and in some cases it is found that the rate of decay of solutions is faster than the optimal decay rate for harmonic functions. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1655-1679 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper the problem of collision analysis for a mobile robot operating in a planar environment with moving objects (obstacles) is addressed. The pattern of motion of the potential obstacles cannot be predicted; only a bound on their maximum velocity is available. Based on this information, at its current position the robot constructs the Hazard Region that corresponds to the path it contemplates. If the Hazard Region contains at least one obstacle, then there is a potential for this obstacle to collide with the robot (in which case perhaps another path should be planned). We first derive the solution for Hazard Region for two standard path primitives, a straight line segment and a circular arc segment; the solution is exact, except for one special case (for which the approximation error is estimated). This result is then applied to a more complex case when the path presents a combination of those primitives. Such are, for example, the optimal (shortest) paths with constrained curvature (known as Dubins paths [3]), which connect two points, each with a prescribed direction of motion. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 64
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1681-1704 
    ISSN: 0170-4214
    Keywords: stratified medium ; acoustic waves ; self-adjoint operators ; spectrum ; limiting absorption principle ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider the acoustic propagator A=-∇·c2∇ in the strip Ω={(x, z)∊∝2∣0〈z〈H} with finite width H〉0. The celerity c depends for large ∣x∣ only on the variable z and describes the stratification of Ω: it is assumed to be in L∞(Ω), bounded from below by cmin〉0, such that there exists M〉0 with c(x, z)=c1(z) if x〈 -M and c(x, z)=c2(z) if x〉M. We look at the propagator A as a ‘perturbation’ of the free propagators Aj in Ω associated to the velocities cj, j=1, 2, and implement a ‘perturbative’ method, adapting ideas of Majda and Vainberg. The spectrum of A is defined in section 2, a limiting absorption principle is proved in section 3 outside of a countable set Γ(A). The points of Γ(A) can only accumulate at the left of the thresholds of the free propagators. The needed material about Aj, j=1, 2, and some technical estimates for A are given in Appendix. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 25-42 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Considered is the rotation of a robot arm or rod in a horizontal plane about an axis through the arm's fixed end and driven by a motor whose torque is controlled. The model was derived and investigated computationally by Sakawa and co-authors in [7] for the case that the arm is described as a homogeneous Euler beam. The resulting equation of motion is a partial differential equation of the type of a wave equation which is linear with respect to the state, if the control is fixed, and non-linear with respect to the control.Considered is the problem of steering the beam, within a given time interval, from the position of rest for the angle zero into the position of rest under a certain given angle.At first we show that, for every L2-control, there is exactly one (weak) solution of the initial boundary value problem which describes the vibrating system without the end condition.Then we show that the problem of controllability is equivalent to a non-linear moment problem. This, however, is not exactly solvable. Therefore, an iteration method is developed which leads to an approximate solution of sufficient accuracy in two steps. This method is numerically implemented and demonstrated by an example. © 1998 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 59-91 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: A time-dependent Ginzburg-Landau-type model of a superconducting-normal-superconducting junction is presented. The existence and the uniqueness of the solutions are proved. When the data of the model are symmetric of some kinds, the solutions turns out to be symmetric of some kinds. In this symmetric case, an approximate model with the small thickness of the normal material in the middle of the junction as coefficients of a differential system is established for the sake of numerical computations. And also the existence and the uniqueness of the solution to this approximate model are set up. © 1998 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 165-185 
    ISSN: 0170-4214
    Keywords: boundary integral equations ; boundary finite element ; free edge polygonal plate ; hypersingular kernels ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We consider the problem of a polygonal plate with free edges. It is a boundary value problem for the biharmonic operator on a polygon with Neumann boundary conditions. Its resolution is studied via boundary integral equations. A variational formulation of the boundary problem obtained by a double-layer potential is given. Finally, we implement the method and give numerical results. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 129-163 
    ISSN: 0170-4214
    Keywords: wavelets on closed surfaces ; Dirichlet's and Neumann's problem ; scaling function ; scale discrete wavelets ; integral formulas ; exact fully discrete wavelet transform ; band-limited harmonic wavelets ; Runge-Walsh approximation ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: Wavelets on closed surfaces in Euclidean space ∝3 are introduced starting from a scale discrete wavelet transform for potentials harmonic down to a spherical boundary. Essential tools for approximation are integration formulas relating an integral over the sphere to suitable linear combinations of function values (resp. normal derivatives) on the closed surface under consideration. A scale discrete version of multiresolution is described for potential functions harmonic outside the closed surface and regular at infinity. Furthermore, an exact fully discrete wavelet approximation is developed in case of band-limited wavelets. Finally, the role of wavelets is discussed in three problems, namely (i) the representation of a function on a closed surface from discretely given data, (ii) the (discrete) solution of the exterior Dirichlet problem, and (iii) the (discrete) solution of the exterior Neumann problem. © 1998 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 417-432 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We state a 1D model with quasi-stationary gas flows approximation for a carbon reactivity test in the production of silicon. The mathematical problem we formulate is a non-linear boundary value problem for a third-order ordinary differential equation with non-linear boundary conditions, which are non-local in time. We prove existence and uniqueness of a classical solution and provide a numerical example. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 281-325 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: We present a bending model for a shallow arch, namely the type of curved rod where the curvature is of the order of the diameter of the cross section. The model is deduced in a rigorous mathematical way from classical tridimensional linear elasticity theory via asymptotic techniques, by taking the limit on a suitable re-scaled formulation of that problem as the diameter of the cross section tends to zero. This model is valid for general cases of applied forces and material, and it allows us to calculate displacements, axial stresses, bending moments and shear forces. The equations present a more general form than in the classical Bernoulli-Navier bending theory for straight slender rods, so that flexures and extensions are proved to be coupled in the most general case. © 1998 by B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 375-392 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this work we analyse a model for radiative heat transfer in materials that are conductive, grey and semitransparent. Such materials are for example glass, silicon, water and several gases. The most important feature of the model is the non-local interaction due to exchange of radiation. This, together with non-linearity arising from the well-known Stefan-Boltzmann law, makes the resulting heat equation non-monotone. By analysing the terms related to heat radiation we prove that the operator defining the problem is pseudomonotone. Hence, we can prove the existence of weak solution in the cases where coercivity can be obtained. In the general case, we prove the solvability of the system using the technique of sub and supersolutions. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 589-603 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In the paper we study the problem of control by means of a heat source g for a thermoelastic system of equationsutt - ρ∇·p(θ, ∇u) - νΔut + DΔ2 u = f, cv(θ, ∇u)θt - κΔθ - ρθ[pθ (θ, ∇u)·∇ut] - ν∣∇ut∣2 = g, in a two-dimensional domain, where both viscosity ν and rigidity D are positive. Such a system has been considered in our former papers, and existence of solutions as well as uniqueness have been obtained. Here we prove the continuity and differentiability of solutions under somewhat stronger assumptions. An example of a control problem and necessary optimality conditions are presented. The system has an interpretation as a plate reinforced with shape memory alloy (SMA) wire mesh. © 1998 B. G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 719-731 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: The exact solutions for the KdV and the Calogero-Degasperis-Fokas mKdV equations can be obtained by the AKNS class. The technique developed relies on the construction of the wave functions which are solutions of the associated AKNS system; that is, a linear eigenvalue problem in the form of a system of first order partial differential equations. The method of characteristics is used and Bäcklund transformations (BTs) are employed to generate two new solutions from the old. © 1998 B.G. Teubner Stuttgart-John Wiley & Sons Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 781-795 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper we consider the boundary value problem for a semilinear equation□u(t, x)-μu(t, x)+aum(t, x)=0, μ〉0, a∊ℜ in the interior domain. We find a time global classical solution with exponential decay property by using singular hyperbolic equation. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 895-906 
    ISSN: 0170-4214
    Keywords: geometrical inverse problems ; crack detection ; identifiability ; stability ; Lipschitz stability ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: This paper deals with the detection of emergent plane cracks, by using boundary measurements. An identifiability result (uniqueness of the solution) is first proved. Then, we look at the stability of this solution with respect to the measurement. A weak stability result is proved, as well as a Lipshitz stability result for straight cracks, by using domain-derivative techniques. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1467-1477 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper, the existence, both locally and globally in time, the uniqueness of solutions and the non-existence of global solutions to the initial boundary value problem of a generalized Modification of the Improved Boussinesq equation utt-uxx-uxxtt=σ(u)xx are studied and a few examples are discussed. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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    Mathematical Methods in the Applied Sciences 21 (1998), S. 1593-1617 
    ISSN: 0170-4214
    Keywords: Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics
    Notes: In this paper we study the following problem:ut-Δu=-f(u) in Ω×(0, T)≡QT,∂u ∂n=g(u) on ∂Ω×(0, T)≡ST,u(x, 0)=u0(x) in Ω, where Ω⊂∝N is a smooth bounded domain, f and g are smooth functions which are positive when the argument is positive, and u0(x)〉0 satisfies some smooth and compatibility conditions to guarantee the classical solution u(x, t) exists. We first obtain some existence and non-existence results for the corresponding elliptic problems. Then, we establish certain conditions for a finite time blow-up and global boundedness of the solutions of the time-dependent problem. Further, we analyse systems with same kind of boundary conditions and find some blow-up results. In the last section, we study the corresponding elliptic problems in one-dimensional domain. Our main method is the comparison principle and the construction of special forms of upper-lower solutions using related equations. © 1998 B. G. Teubner Stuttgart - John Wiley & Sons, Ltd.
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  • 78
    ISSN: 0935-6304
    Keywords: Epoxytriacylglycerols ; high temperature gas chromatography ; hydroxytriacylglycerols ; ketotriacylglycerols ; lipids ; negative chemical ionization mass spectrometry ; SOP-50 ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Five seed oils consisting of unusual triacylglycerols have been examined by high temperature gas chromatography using glass capillary columns coated with the stationary phase SOP-50 (50%-diphenyl-50%-dimethylpolysiloxane, methoxy-terminated). The investigated hydroxy, epoxy, and ketokonjuene triacylglycerols were first derivatized in order to permit analysis by high temperature gas chromatography. Structural elucidation of the intact triacylglycerols was performed with high temperature gas chromatography/negative chemical ionization-mass spectrometry using NH3 as a reagent gas. Individual derivatized lipid species with a molecular weight up to 1176 g/mol could be identified.
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    Journal of High Resolution Chromatography 21 (1998), S. 169-174 
    ISSN: 0935-6304
    Keywords: CZE ; detection limit ; signal-to-noise ratio ; correlation chromatography ; reproducibility ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Poor signal-to-noise ratios and analytical reproducibility in capillary electrophoresis were improved by application of multiple injections of the same sample at (pseudo) randomly chosen time moments. One order of signal-to-noise ratio improvement was achieved in practice using an in-house developed computer-controlled pneumatic sampler. However, it is demonstrated here that better implementation of the capabilities of multiple input requires that the detector signal noise be “pre-whitened”, i.e. spikes, baseline drift, oscillations etc. must be removed from the detector signal before transforming it to the electropherogram in the common form. Such filtering of the detector signal was realized by implementing iterative, menu-driven software written in Matlab, a high-level programming language.
    Additional Material: 5 Ill.
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  • 80
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 181-184 
    ISSN: 0935-6304
    Keywords: Trace analysis, atmospheric ; digital signal processing ; signal to noise reduction ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
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  • 81
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 189-192 
    ISSN: 0935-6304
    Keywords: Chiral stationary phases ; pyrethroic acids ; enantiomer separation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 82
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 193-196 
    ISSN: 0935-6304
    Keywords: capillary electrophoresis ; dissolving solvent selection ; optimization ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 83
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 201-208 
    ISSN: 0935-6304
    Keywords: PAN ; peroxyacetyl nitrate ; alkyl nitrate ; chlorinated hydrocarbons ; halocarbons ; capillary GC-ECD ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A cryogenic preconcentration/high-resolution gas chromatographic technique has been developed for the rapid, simultaneous quantitation of C1-C4 organic nitrates and halocarbons in ambient air. Whole-air samples are collected in TedlarTM bags by an evacuated-chamber method. Samples were stable in 0.010-cm-thick bags for 24 h if they were immediately stored in a freezer at -25°C. Analytes in a 50-cm3 air sample were efficiently preconcentrated on fused-silica beads at -180°C and thermally desorbed at 30°C. High-resolution gas chromatography with a cross-linked polydimethylsiloxane fused-silica capillary column and an electron-capture detector were used for separation and quantitation of the analytes. An analysis time of about 12 min was facilitated by sample cryofocusing at -180°C and oven temperature programming. Recoveries of the analytes by the evacuated-chamber method were better than 95%. The sensitivity of the technique for sample volumes of 50 cm3 is in the sub-parts-per-trillion by volume (ppt[v]) range for many of the analytes, with an average precision of about ±5% for analytes at levels of about 10 ppt(v).
    Additional Material: 4 Ill.
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  • 84
    ISSN: 0935-6304
    Keywords: capillary electrophoresis ; enantiomer separation ; hydroxypropyl-β-cyclodextrin ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Following an extended screening project, 86 racemic drugs were investigated by capillary zone electrophoresis in the presence of the chiral solvating agent (CSA) hydroxypropyl-β-cyclodextrin. A total of 42 drugs out of 86 tested was thereby separated into enantiomeric pairs. Statistical analysis of the numerous experiments performed un der identical conditions reveals a loose correlation of the migration separation factor (αm) with the migration retardation factor (Rm). For a subset of 23 drugs, a drop in the concentration of the CSA was also studied, showing the way to further optimization.
    Additional Material: 6 Ill.
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  • 85
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 253-257 
    ISSN: 0935-6304
    Keywords: Edible oils ; lipids in foods ; HPLC ; Polycyclic Aromatic Hydrocarbons (PAHs) ; off line LC-LC ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
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  • 86
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 234-240 
    ISSN: 0935-6304
    Keywords: Micellar electrokinetic capillary chromatography ; electroosmotic migration ; electrophoretic migration of micelle ; retention mechanism ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---In the present work, four organic modifiers, viz. urea, dioxane, methanol, and tetrahydrofuran, were comparatively and systematically studied in terms of their effects on electrokinetic migration behavior and the retention mechanism of homologous solutes in MECC. The results showed that the electroosmotic mobility, μeo, and the electrophoretic mobility of a micelle, μep,mc, decrease linearly with increasing organic modifier concentration. The ability of organic modifiers to lower μeo is greater than their ability to lower μep,mc. The negative values of the slopes of these linear relationships, Deo and Dep,mc, increase along the series the order urea 〈 methanol 〈 dioxane 〈 tetrahydrofuran. The logarithm of the capacity factor (ln k′) of uncharged homologous solute, which is mainly determined by the hydrophobic interaction, decreases linearly with increasing organic modifier concentration, due not only to the decrease in the partition coefficient but also to the decrease in the phase ratio. A linear relationship was observed between the slope of the plot of ln k′ vs. organic modifier concentration and the carbon number of homologous compound. The slope of such a relationship can characterize the hydrophobicity of the organic modifier. The hydrophobicity of such organic modifiers is also found to increase along the series urea 〈 methanol 〈 dioxane 〈 tetrahydrofuran.
    Additional Material: 7 Ill.
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  • 87
    ISSN: 0935-6304
    Keywords: Fluoroquinolone ; ASTED ; HPLC fluorescence ; sarafloxacin ; flumequine ; oxolinic acid ; chicken liver ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A recently introduced programmable fluorescence detector was compared with a single wavelength fluorescence detector for quantification of fluoroquinolone (FQ) antibacterial agents, which have widely varying spectral characteristics. The two detectors were connected in parallel to an HPLC system to test their performance characteristics. With single wavelength detection, two FQs, flumequine and oxolinic acid could be detected at an emission wavelength of 368 nm in a single chromatogram while a third FQ, sarafloxacin, was not observed at that wavelength. Similarly, when the detector was optimized for sarafloxacin emission at 440 nm, the other two compounds were undetected. In contrast, all three FQs were quantified at their individual maxima in a single run using the programmable fluorescence detection. The applicability of an HPLC - programmable fluorescence detector, in combination with on-line microdialysis, also was evaluated using chicken liver fortified at low ppb levels with the three FQs. After on-line microdialysis sample clean up, the resultant HPLC chromatograms were free of background interference enabling the programmable detector to optimize the quantitation of the three analytes in a single run. The limit of quantification (LOQ) determined for each FQ was 1.0 ppb and the limit of detection (LOD) was 0.2 ppb, an order lower in magnitude than was obtainable with single wavelength detection.
    Additional Material: 3 Ill.
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  • 88
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 267-281 
    ISSN: 0935-6304
    Keywords: Chemically bonded phases, CBPs ; liquid chromatography, HPLC ; preparation; surface characterization ; column evaluation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---In order to increase chromatographic selectivity and to extend the analytical capability of reversed phase liquid chromatography (RP HPLC) many investigators have concentrated on the preparation of silica based column packings with chemically bonded phases (CBP). These phases have also been successfully used in sample preparation techniques, mainly in solid phase extraction (SPE). Although alkyl bonded phases (e.g., C2, C8, and C18) are the most widely used packings in RP HPLC and SPE, various specific applications require CBPs with polar functional groups (e.g., -NH2, -NO2, -CN, and/or -OH). The solution of problems with separation of complicated chiral compounds was attempted by applying stationary phases with chiral selectors (e.g., cyclodextrins, Pirkle phases, crown ethers, etc.). On the other hand, packings with pseudo-membrane or liquid crystal properties have been utilized for the separation of various substances of natural origin. Porous silica is commonly used as a support in the preparation of CBPs. Its physico-chemical characteristics, such as: type and structure of siliceous matrix, porosity, type and concentration of silanol groups, as well as surface purity, strongly influence the density and structure of chemically bonded phases. Recognition of these properties is helpful in optimizing separation processes based on RP HPLC elution and/or extraction of substances with polar character.
    Additional Material: 12 Ill.
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  • 89
    ISSN: 0935-6304
    Keywords: capillary gas chromatography ; microplasma mass spectrometry ; radio frequency plasma ; element-selective detection ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Capillary gas chromatography was performed with mass spectrometric detection using a novel microplasma ion source for operation in an element-selective mode. The ion source was a 350 kHz radio frequency helium plasma, which was sustained inside the 4 cm end of a 0.32 mm i.d. fused silica capillary column, and located inside the high vacuum chamber of the quadrupole mass spectrometer. Due to the low volume of the ion source, a stable low pressure discharge was produced utilizing only the 2.25 mL min-1 of GC carrier gas (helium) for plasma support. Small amounts of oxygen (0.1-0.2% v/v) were added to the plasma gas in order to prevent carbon deposits and to enhance signal-to-noise ratios. Chlorine and bromine were selectively detected at the 5-20 pg s-1 level (S/N = 2), and both produced a response that was linear within 3 orders of magnitude.
    Additional Material: 3 Ill.
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  • 90
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 315-316 
    ISSN: 0935-6304
    Keywords: Tertiary amine ; ruthenium ; chemiluminescence ; photochemical oxidation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
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  • 91
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 303-307 
    ISSN: 0935-6304
    Keywords: gas chromatography ; modified silica gel ; gaseous standard mixtures ; FID calibration ; carbon monoxide and carbon dioxide ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---Quartz rods coated with a thin layer of chemically modified silica gel have been used for the generation of a two-component gaseous standard mixture containing carbon monoxide and carbon dioxide. A new method based on thermal decomposition of immobilized compounds chemically bonded to the surface of silica gel has been used in the generation process. The oxalic acid moiety bonded to the glycydoxypropylsilylated surface of silica gel underwent decarbonylation and decarboxylation at 300°C, yielding carbon monoxide and carbon dioxide. On-line connection of a thermal desorber with the GC/FID enabled calibration of the detector following the process of methanization of CO and CO2. The following amounts of CO and CO2 were generated per unit length of the rod: 15.1 × 10-8 Mol cm-1 (RSD = 5.71%) for CO and 34.2 × 10-8 Mol cm-1(RSD = 5.16%) for CO2.
    Additional Material: 4 Ill.
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  • 92
    ISSN: 0935-6304
    Keywords: Large-volume on-column injection ; gas chromatography ; infrared spectrometry ; microcontaminants ; solid-phase extraction ; open-split interface ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A large-volume on-column GC-cryotrapping-IR system was developed for injections of up to 100 μl of organic extracts. Considerable reduction of the solvent-and-water background and enhanced analyte detectability was achieved by using an open-split interface between the GC column and the IR detector and improving the leak-tightness of the system. The system was combined with solid-phase extraction to yield on-line SPE-GC-IR. With this set-up, sample volumes of only 20 ml sufficed to detect, and identify, microcontaminants in tap and surface water at the 0.1-1 μg/L level. Detection limits were on the order of 15 ng/L for tap water when using appropriate functional-group chromatograms. Or, in other words, SPE-GC-IR is a suitable technique for the screening of environmental water samples for functional groups, i.e. classes of compounds, of interest.
    Additional Material: 5 Ill.
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  • 93
    ISSN: 0935-6304
    Keywords: Adsorption/thermal desorption sampling instrument ; capillary gas chromatography ; electrolytic conductivity detector ; photoionization detector ; environmental air monitoring ; hazardous air pollutants ; volatile organic compounds ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 94
    ISSN: 0935-6304
    Keywords: Scent glands ; defense substances ; n-alkanes ; furanones ; 2-alkenals ; 2-alkenyl acetates ; 2-decenols ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 95
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 491-497 
    ISSN: 0935-6304
    Keywords: Fast GC ; narrow-bore columns ; trace analysis ; splitless injection ; on-column injection ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---The use of hot splitless, cold splitless, and on-column injections for trace analysis in narrow-bore capillary GC is evaluated. Despite the low flow rates for the columns used, the required splitless times for splitless injections can be surprisingly short if liners with a small inside diameter are used. On-column injection can be applied by using an appropriate normal-bore precolumn coupled to the narrow-bore analytical column using a specially designed low dead volume column connector. The effects of the experimental conditions such as sample volume, injection temperature, and initial oven temperature on peak focusing and the discrimination and degradation behavior of the analytes are discussed. The possibilities to obtain sensitive and fast separations are illustrated by various applications.
    Additional Material: 7 Ill.
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  • 96
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 505-508 
    ISSN: 0935-6304
    Keywords: capillary electrophoresis ; inorganic ions ; polyethyleneimine ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A capillary zone electrophoresis (CZE) method for the simultaneous assay of bromide, iodide, nitrite, nitrate, and thiocyanate using direct UV detection is reported. The method is based on the separation of anions in a capillary coated with a cationic polymer, polyethyleneimine (PEI). The minimum detection limits, reproducibility of peak areas, and migration times were determined at the optimal condition. The method was applied to the analysis of tap water and human urine. The changes in separation selectivity of the anions resulting from addition of the cationic polymer to the buffer were investigated.
    Additional Material: 5 Ill.
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  • 97
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 523-526 
    ISSN: 0935-6304
    Keywords: High-performance liquid chromatography ; gardenia constituent separation ; genipin gentiobioside ; geniposide ; crocin ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 98
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 435-439 
    ISSN: 0935-6304
    Keywords: Micellar Electrokinetic Chromatography (MEKC) ; counter pressure moderated MEKC ; migration time window ; peak resolution and peak capacity in MEKC ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---The influence of a hydrostatic counter pressure on basic mobility equations in MEKC was analyzed theoretically and investigated experimentally. Taking into account the influence of counter pressure, the modified mobility equations predict a decreased migration time ratio t0/tMC, which was confirmed by results obtained in SDS-MEKC separation of a homologous series of n-alkyl phenyl ketones. As a result, the migration time window could be enlarged in a simple way without having to change the chemistry of the system. Although counter pressures reduce peak efficiency in MEKC by disturbing the plug profile, the concomitant enlargement of the migration time window compensates for this effect. Especially for later migrating compounds, peak resolution could be enhanced at moderate counter pressures. The overall peak capacities within the whole migration window increases slightly when applying counter pressures up to 10 mbar.
    Additional Material: 3 Ill.
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  • 99
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 445-449 
    ISSN: 0935-6304
    Keywords: chiral separation ; organic cation effect ; ethylamines ; ethanolamines ; basic drugs ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---This paper addresses the influence of small organic cations in the background electrolyte (BGE) on chiral separation by capillary zone electrophoresis (CZE). Seven basic drugs, viz. alprenolol, amphetamine, anisodamine, isoprenaline, pinacidil, synephrine, and verapamil were used as test compounds with hydroxylpropyl-β-cyclodextrin (HP-β-CD) as the chiral selector. Resolution of the chiral test compounds was studied at pH 2.5 in the presence of Tris, ethanolamine, diethanolamine, triethanolamine, diethylamine, and triethylamine, which exist in their cationic forms at this pH value. Among the six cationic additives studied, triethylamine is most effective in enhancing resolution. A tentative mechanism of the effect is proposed.
    Additional Material: 7 Ill.
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  • 100
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    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 569-573 
    ISSN: 0935-6304
    Keywords: Chinese herbal preparation ; Shao-yao-tang ; pharmaceutical analysis ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A high-performance liquid chromatographic method for the separation of twenty one constituents of Shao-yao-tang including six flavonoids, six alkaloids, three anthraquinones, three carboxylic acids, one monoterpene, one saponin, and one aldehyde was developed. Detection at 275 nm with a linear gradient elution system consisting of tetrabutylammonium bromide (TBA) and acetic acid solution was found to be suitable for determination of nineteen marker substances in an unpretreated Shao-yao-tang extract within 75 min. This method can also be used to analyze 11-14 components in a number of Chinese herbal preparations such as San-huang-hsieh-hsin-tang, Ching-chieh-lien-chiao-tang, San-tsung-kuei-chien-tang, Chai-hu-ching-kan-tang, and Ching-yin-li-ke-tang.
    Additional Material: 3 Ill.
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