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  • 1980-1984
  • 1975-1979  (711)
  • 1975  (711)
  • Analytical Chemistry and Spectroscopy  (516)
  • Electron microscopy  (111)
  • Engineering General  (84)
  • Nuclear reactions
Source
Material
Years
  • 1980-1984
  • 1975-1979  (711)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural study of calcium-containing precipitation in human parathyroid glands (1975)
    Springer
    Virchows Archiv 368 (1975), S. 99-108 
    Details
    ISSN: 1432-2307
    Keywords: Electron microscopy ; Calcium ; Parathyroid glands ; Chief cells ; Oxyphil cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the potassium pyroantimonate technique for ultrastructural localization of cations and X-ray elemental analysis with both energy dispersive and wave-length dispersive systems, calcium-containing precipitates were found in normal, hyperplastic and adenomatous human parathyroid glands. Differences were observed between oxyphil cells, and suppressed, stimulated and active chief cells in the content and localization of intracellular precipitation. The oxyphil cells and suppressed chief cells possessed precipitates mainly in nuclei and medium-sized and large mitochondria, whereas the stimulated chief cells possessed precipitates in normal-appearing and morphologically altered mitochondria, and in smooth-surfaced vacuoles and cytosol. The active chief cells usually showed a rather sparse precipitation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432411
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  • 2
    Electronic Resource
    Electronic Resource
    Déficit en alpha-1-antitrypsine chez l'enfant (1975)
    Springer
    Virchows Archiv 369 (1975), S. 19-27 
    Details
    ISSN: 1432-2307
    Keywords: Alpha-1-antitrypsin deficiency ; Liver ; Electron microscopy ; Endoplasmic reticulum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fourteen liver biopsies from twelve young patients with liver diseases associated with homozygous, PiZZ phenotype, alpha-1-antitrypsin deficiency in their sera were examined by electron microscopy. In all these biopsies characteristic homogeneous material was found in some hepatocytes and corresponded, when observed on adjacent semithin sections by light microscopy, to the deposit stained by periodic acid Schiff reaction. The accumulation in perinuclear spaces resulted in intranuclear invaginations, but the major deposit was located in lumens of the endoplasmic reticulum. The limiting membranes were rough and smooth but the extent of the latter was so large that only this type of reticulum seemed peculiarly involved in the accumulating process. On the contrary, Golgi complexes did not seen obligatorily involved by this process because, when observed, they appeared almost normal even in heavily overloaded liver cells. At least for the PiZZ phenotype, the abnormal substance would be an asialo form of normal alpha-1-antitrypsin. Thus the subject of this study is the morphologic translation of an impairment in the synthesis of a glycoprotein. In the light of data concerning the synthesis of such proteins our findings lead us to suggest: The ultrastructural patterns observed in alpha-1-antitrypsin deficiency cannot give the expected morphologic evidence of the biochemical data which locate the first binding steps of monosaccharide residues in the rough endoplasmic reticulum. The absence of sialic acid could not result from an enzymatic defect primarily located in Golgi complexes but could be secondary to an impairment in the binding of one monosaccharide residue which improves subsequent fixation of sialic acid, in the smooth endoplasmic reticulum. Finally it seems necessary to emphasize that the relationship between the abnormal substance and various important non specific lesions is largely unknown and that we don't know the significance of polymorphous dense bodies observed in ductular cells during the cholestatic period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432458
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  • 3
    Electronic Resource
    Electronic Resource
    Zur Ultrastruktur fibröser und histiocytärer Hauttumoren (Dermatofibrom, Dermatofibrosarcoma protuberans, Fibroxanthom und Histiocytom) (1975)
    Springer
    Virchows Archiv 368 (1975), S. 253-274 
    Details
    ISSN: 1432-2307
    Keywords: Tumors of the skin ; Histogenesis ; Classification ; Labyrinth nuclei ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über den Feinbau folgender Hauttumoren berichtet: Dermatofibrom (7 Fälle), Histiozytom (4 Fälle), Dermatofibrosarcoma protuberans (1 Fall) und Fibroxanthom (1 Fall). Aufgrund ihrer unterschiedlichen ultrastrukturellen Merkmale ist eine zweifache Unterteilung dieser Hauttumoren möglich: In eine Tumorgruppe, umfassend das Dermatofibrom, Dermatofibrosarcoma protuberans und Fibroxanthom, bei der die Faserbildung im Vordergrund steht und für deren Histogenese Fibroblasten angenommen werden können. Diese Tumortypen unterscheiden sich vom Histiozytom, dessen Zellcharakter vor allem durch die stark ausgeprägte Phagozytose- und Speichertätigkeit (Fett und Hämosiderin) bestimmt wird und für welches eine histogenetische Ableitung von Histiozyten wahrscheinlich ist. Die Zellkerne des Dermatofibromes und des Histiozytomes weisen einen einfachen Oberflächenverlauf auf, die des Dermatofibrosarcoma protuberans und Fibroxanthomes haben hingegen sehr stark gegliederte Formationen („Labyrinthkerne”). Diese Kernsegmentierung ist für das Dermatofibrosarcoma protuberans ein morphologisches Korrelat seiner Semimalignität. Eine Klassifizierung der faserbildenden Tumoren als „fibröse Histiozytome” erscheint aufgrund der ultrastrukturellen Analyse nicht gerechtfertigt.
    Notes: Summary A report on the ultrastructure of the following skin tumors: dermatofibroma (7 cases), histiocytoma (4 cases), dermatof ibrosarcoma protuberans (1 case), and fibroxanthoma (1 case). Because of their different ultrastructural characteristics a division into two groups is possible: one group of tumors would include dermatofibroma, dermatofibrosarcoma protuberans, and fibroxanthoma, where the formation of fibers is extensive and fibroblasts are suggested for its histogenesis. These types of tumor differ from histiocytoma, the cellular character of which is determined by a very pronounced phagocytosis and storage of lipid and hemosiderin; a histogenesis from histiocytes is probable. The nuclei of dermatofibroma and histiocytoma show a simple surfacedevelopment, whereas the nuclei of dermatofibrosarcoma protuberans and fibroxanthoma show multisegmented nuclei (“labyrinth nuclei”). In the case of dermatofibrosarcoma protuberans this kind of nuclear segmentation seems to be a morphologic correlate of its semimalignancy. Based on ultrastructural analysis a classification of these fiber-producing tumors into “fibrous histiocytomas” is not justified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432527
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  • 4
    Electronic Resource
    Electronic Resource
    Late changes of irreversible post-partum renal failure (1975)
    Springer
    Virchows Archiv 367 (1975), S. 171-179 
    Details
    ISSN: 1432-2307
    Keywords: Kidney failure ; Pregnancy ; Electron microscopy ; Hemolytic-uremicsyndrome ; Basement membrane ; Endothelium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinico-pathological data from a patient with irreversible post-partum renal failure (IPRF) are presented. The electron microscopy of the late changes are described for the first time and consists of: 1. Thickening of the basement membrane. 2. Interposition of mesangial cells and matrix between the thickened basement membrane and the endothelial cell encircling the periphery of the tuft. 3. Multiplication of basal lamina material between mesangial cells and endothelial cells. 4. Proliferation of endothelial cells. All of the above changes tend to obliterate the glomerular tufts and transform the vascular lumina into slit-like spaces. They explain morphologically why most patients with IPRF terminate in chronic renal failure, if they survive the early changes. The late occurring hypertension is regarded as a secondary stimulation of the renin-angiotension system caused by partial or complete occlusion of arteries and arterioles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430705
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructural localization of plasma lipoproteins in human intracranial arteries (1975)
    Springer
    Virchows Archiv 369 (1975), S. 111-121 
    Details
    ISSN: 1432-2307
    Keywords: Atherosclerosis ; apoB ; LDL ; VLDL ; Immunoperoxidase ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine-structural localization of apoB, the major protein constituent of both the low and very low density plasma lipoprotein fractions, was described in human middle cerebral and basilar arteries. Using an immunoperoxidase technique together with electron microscopy, apoB was localized only in arteries with atherosclerotic involvement and to the following regions in these arteries: 1. on the outer aspects of extracellular spherical structures with diameters of 250 to 700 Å found predominantly in lipid cores and between bands of collagen fibers of advanced atherosclerotic lesions; 2. on the surface of reduplicated elastica; 3. along collagen fibers and; 4. on aggregates of extracellular spherical lipid globules. These results suggest that the extracellular spheres may represent the fine-structural morphology of deposited low and very low density lipoproteius and that free apoB may be bound to lipid globules, elastica, and collagen fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433237
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  • 6
    Electronic Resource
    Electronic Resource
    Differentiation of sympathicoblasts in cultures of chick ganglia (1975)
    Springer
    Anatomy and embryology 146 (1975), S. 225-243 
    Details
    ISSN: 1432-0568
    Keywords: Differentiation ; Sympathetic ganglion ; Culture ; Electron microscopy ; Histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immature sympathetic ganglia prepared from 51/2- or 6-day-old chick embryos were cultured up to one month. The in vitro development was followed by phase microscopy, electron microscopy and using histochemistry for catecholamines, monoamine oxidase and cholinesterases. During the first week of culture extensive plexuses of nerve fibres were formed between and around the clusters of nerve cells. Mature-looking neurons were observed in the cultures by phase microscopy after three weeks, at which age the mean diameter of the perikarya was more than doubled. Varying catecholamine fluorescence was observed in the perikarya during the entire culture period. The nerve fibres showed usually only weak fluorescence, but, in the older cultures, bright varicosities were regularly found in the fibres. Monoamine oxidase activity was demonstrated already at three days of culture and the reaction was maintained positive. Weak or moderate acetyl-cholinesterase activity was demonstrated in the sympathicoblasts and young sympathetic neurons and their processes. The axolemma showed acetylcholinesterase activity also around the nerve terminals containing small dense cored vesicles. Reactions for the non-specific cholinesterases were negative. Electron microscopy of the 30-day-old cultures revealed that the clusters of nerve cells consisted of mature sympathetic neurons, which contained large (60–200 nm) and small (35–60 nm) granular catecholamine-storing vesicles. Glial cells were almost totally lacking. Large numbers of nerve terminals containing both large and small granular vesicles were observed in the clusters, often in synaptic contact with the sympathetic neurons. It is concluded that the primitive sympathicoblasts are, in favourable conditions, capable of differentiation in culture up to mature sympathetic neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302172
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  • 7
    Electronic Resource
    Electronic Resource
    In utero development and maturation of the retina of a non-primate mammal: A light and electron microscopic study of the guinea pig (1975)
    Springer
    Anatomy and embryology 146 (1975), S. 279-300 
    Details
    ISSN: 1432-0568
    Keywords: Retinogenesis ; Synaptogenesis ; Guinea pig ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A light and electron microscopic examination of retinogenesis in the fetal guinea pig has revealed an early development of synapses and photoreceptor cells. Differentiation of the neural retina begins around day 23 of gestation. By 34 days the retina reaches its maximum thickness. It differentiates an inner plexiform layer in which vesicle-containing processes and primitive synapses are evident. Synaptic ribbons are found in processes of this layer by 43–45 days of gestation. An outer plexiform layer develops within the neuroblast layer at 40 days of gestation; from its first appearance the outer plexiform layer contains synapses complete with synaptic ribbons. Receptor terminals of the α, paranuclear and β type are present well before birth. Photoreceptor cells form inner segments by 40 days; the formation of outer segments is indicated by 45 days but not widespread until 49 days. The retina appears mature by day 51–57. It is clear that the primate is not unique in the early differentiation of its retinal synapses relative to the time of maturation of its photoreceptor cells. The potential functional capacities of precocious retinae, and the mechanisms of synapse development are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302175
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  • 8
    Electronic Resource
    Electronic Resource
    Melanogenesis in the pigment epithelium of chicken embryos (1975)
    Springer
    Anatomy and embryology 147 (1975), S. 177-187 
    Details
    ISSN: 1432-0568
    Keywords: Iris ; Melanogenesis ; Chicken embryo ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The iris anlage of 2–10 and 15 days old chicken embryos were studied histochemically, and by both light and electron microscopy. Light microscopic serial sections showed that pigmentation began at the outer layer of the posterior eye pole and progressed from there forwards to the optic cup margin. The entire outer layer of the optic cup as well as the pupillary margin were completely pigmented by the 4th day of incubation. By the 10th day the posterior iris epithelium was totally pigmented. Electron microscopical studies showed that the first premelanosomes appeared at about the 3rd day of incubation in the anterior iris anlage with the exception of the pupillary margin. It could be shown that melanogenesis progressed through the following steps: premelanosomes, followed by tyrosinase activity in a Golgi-associated system of smooth endoplasmic reticulum (GERL) and small vesicles and finally differentiation of the melanosomes. The possible origin of the premelanosomes and the formation of melanin are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306732
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  • 9
    Electronic Resource
    Electronic Resource
    An ultrastructural comparison of implantation in young and senescent golden hamsters (1975)
    Springer
    Anatomy and embryology 147 (1975), S. 293-307 
    Details
    ISSN: 1432-0568
    Keywords: Implantation ; Golden hamster ; Senescent ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Implantation was compared in young (3–5 month) and senescent (14–17 month) golden hamsters at 3, 31/2, 4, 41/2, 5, and 51/2 days of pregnancy (post-ovulation). One hundred twenty-two embryos (89 from 22 young females and 33 from 18 senescent females) located in utero by cutting thick sections (1–3 μm), were re-embedded and thin-sectioned for electron microscopy. Ultrastructurally implantation and embryonic differentiation was delayed approximately 12 hours in the senescent hamster when compared with young hamsters at the same stage of pregnancy. Failure of the blastocyst to implant would not appear to be a major cause of the declining litter size in aged golden hamsters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315077
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  • 10
    Electronic Resource
    Electronic Resource
    A study of the perineurium in peripheral nerve pathology (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 257-270 
    Details
    ISSN: 1432-0533
    Keywords: Perineurium ; Pathology ; Electron microscopy ; Homeostasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response of the perineurium to the following experimental systems was investigated by light and electron microscopy: nerve crush, cold lesion and microinjection of (a) histamine liberator, (b) potassium cyanide, (c) lysophosphatidyl choline (LPC). Where myelin breakdown occurred, lipid globules were seen within Schwann cells, macrophages and also perineurial cells. Where increased vascular permeability occurred, proteinaceous material leaked from endoneurial vessels into the endoneurial space and later appeared between perineurial laminae. It is suggested that the normal homeostatic function of the perineurium is extended in pathology to the removal of protein and lipid debris. In this way the perineurium contributes to the restoration of the normal microenvironment of peripheral nerve fibres.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688398
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  • 11
    Electronic Resource
    Electronic Resource
    Origin and ultrastructure of intra-hyphal hyphae in Trichophyton terrestre and T. rubrum (1975)
    Springer
    Archives of microbiology 106 (1975), S. 195-200 
    Details
    ISSN: 1432-072X
    Keywords: Trichophyton terrestre ; Trichophyton rubrum ; Hyphal fusions ; Origin of intra-hyphal hyphae ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A cell observation chamber was designed to perform continuous photomicroscopic observations of hyphal anastomosis and the origin of intra-hyphal hyphae in Trichophyton terrestre and T. rubrum. These data were correlated with ultrastructural features of intra-hyphal hyphae. Hyphal fusions occurred commonly in either species of Trichophyton when incubated alone. In T. terrestre, empty hyphal segments adjoined by live units were invaded at the septa from both directions by new hyphal ingrowth. Continuous observations revealed that the intra-hyphal hyphae subsequently anastomosed via a lateral fusion peg. Similar intra-hyphal hyphae were shown in T. rubrum. Electron microscopic studies revealed ascomycetous septa in both conventional hyphae and intra-hyphal hyphae. For the latter, the cytoplasm and wall of the inner hypha were bounded by cytoplasmic organelles and another cell wall of the outer hypha.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446523
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  • 12
    Electronic Resource
    Electronic Resource
    Micro-autoradiographic studies on host-parasite interactions (1975)
    Springer
    Archives of microbiology 105 (1975), S. 193-199 
    Details
    ISSN: 1432-072X
    Keywords: Bean ; Rust ; Haustorium ; Sheath ; Autoradiography ; Infection ; Electron microscopy ; Phaseolus vulgaris ; Uromyces phaseoli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Tritium labeled uredospores of Uromyces phaseoli were produced be feeding the host, Phaseolus vulgaris, with 3H-orotic acid. These spores were allowed to germinate on and to penetrate into a bean leaf. 24 hrs after inoculation, the bean rust had formed the first haustorium. All fungal structures, including the fungus walls, were heavily labeled. No label could be detected in the cells that had come into contact with the hyphae. In the infected host cell, the haustorium was labeled heavily, but the sheath around the haustorium and the host cell remained free of label. These results indicate that no detectable amounts of label leach from the bean rust into the host at this stage of infection although it is known that the rust takes up many metabolites. Since the sheath remains free of label and all fungal structures are evenly labeled, it is concluded that the sheath is formed by the host.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00447137
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  • 13
    Electronic Resource
    Electronic Resource
    Symmetrical infantile thalamic degeneration with focal cytoplasmic calcification (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 1-8 
    Details
    ISSN: 1432-0533
    Keywords: Thalamus ; Cytoplasmic calcospherules ; Non-dystrophic ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Infantile thalamic degeneration is a rare clinico-pathological entity. Restricted location of the lesion and peculiar cytopathological changes serve to distinguish this disorder from other common encephalopathies. Optical and ultrastructural studies demonstrate cytoplasmic calcopherules in previously viable cells. According to current concepts of acute cellular reactions to injury and mechanism of intracellular calcification, the cytological changes cannot be attributed to either hypoxic ischemic cell change or dystrophic calcification. By analogy to other human and pathological material, the most likely basis for nondystrophic calcopherule formation is toxic or infectious injury with local synthesis, or autophagic or phagolysosomal degradation of cellular debris of specific chemical composition favoring calcium deposition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685959
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  • 14
    Electronic Resource
    Electronic Resource
    Epileptic activity and anatomical characteristics of different lesions in cat cortex. Ultrastructural study (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 143-152 
    Details
    ISSN: 1432-0533
    Keywords: Electron microscopy ; Experimental epilepsy ; Oedema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three different types of lesions have been studied in the cortex of the cat, by means of electroencephalography and electron microscopy. These three types of lesions can be listed in order of increasing magnitude according to their capacity to induce abnormal electrical activity: 1. incision of the cortex gives paroxymal activity, 2. intracortical insertion of a resin pellet generates weak epileptic activity, 3. intracortical insertion of a cobalt resin pellet produces epileptic activity. A parallel can be drawn between electrophysiological and anatomical data: there seems to be a quantitative relationship between the degree of epileptic activity and the extent of perilesional tissue. Furthermore, in this perilesional tissue, oedema is observed, the intensity of which varies according to the type of lesion. Thus, the epileptic activity of a lesion seems to be proportional not only to the volume of the perilesional tissue but also to the development of the oedema.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687540
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  • 15
    Electronic Resource
    Electronic Resource
    Electron microscopic investigation of inclusion material in a case of adult metachromatic leukodystrophy; Observations on kidney biopsy, peripheral nerve and cerebral white matter (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 165-171 
    Details
    ISSN: 1432-0533
    Keywords: Adult metachromatic leukodystrophy ; Brain ; Peripheral nerve ; Kidney ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fine structural characteristics of storage products in peripheral nerve, kidney and cerebral white matter, from a case of adult metachromatic leukodystrophy are described. There were pronounced differences from the fine structural aspects in late infantile cases. A large proportion of the inclusions did not exhibit a unit membrane. An hypothesis is proposed to clarify the delayed manifestation of this type of metachromatic leukodystrophy until adulthood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687542
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  • 16
    Electronic Resource
    Electronic Resource
    Niemann-Pick disease (Crocker's type C) (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 191-200 
    Details
    ISSN: 1432-0533
    Keywords: Niemann-Pick disease ; Storage distribution ; Cerebral vascular glycolipid ; Histochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A histochemical study is reported of regional differences of the lipid storage in a case of Niemann-Pick disease (NPD) type C. Besides tissues known to be affected (reticuloendothelium, hepatocytes, nervous system), storage was demonstrated in adrenal cortical spongiocytes, sweat glands, renal glomerular and tubular cells, smooth muscle, excretory tubules of some salivary glands, ependyma and in choroid plexus. In most tissues were stored sphingomyelin, cholesterol and a small amount of a glycosphingolipid. In the endothelium of cerebral and spinal vessels the main stored lipid was a glycosphingolipid. The significance of these regional differences are discussed and their study is recommended as a useful counterpart to the biochemical investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688393
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  • 17
    Electronic Resource
    Electronic Resource
    The myocardium in Lafora disease (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 343-349 
    Details
    ISSN: 1432-0533
    Keywords: Lafora disease ; Myocardium ; Deposits ; Enzame histochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histological, histochemical and electron microscopic studies on the myocardium of 3 Japanese patients with Lafora disease were carried out. Deposits in the myocardium stained positively with PAS, Best's carmine and Lugol's indine. After digestion of the sections with α-amylase, the deposits disappeared or were less intense, in particular with PAS staining. Phosphorylase activity was deficient in the myocardium of Case 3, when compared with controls, both of which were kept frozen at −20°C following autopsy. Electron microscopy revealed that the deposits were not membrane-bound and consisted of fine particles and fibrillae. The nature of the deposits is diseussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686166
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  • 18
    Electronic Resource
    Electronic Resource
    Vascular and neuroglial changes in experimental herpes simplex encephalitis (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 245-256 
    Details
    ISSN: 1432-0533
    Keywords: Herpes simplex encephalitis ; Blood-vessels ; Reactive microglia ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Generalized vascular changes and diffused proliferation of reactive microglia were observed in an experimental model of HSV encephalitis of mice. The wide spread of these changes contrasted with the localized character of virus replication and the confined areas of damaged nervous tissue. The vascular and microglial changes were precocious in animals inoculated with concentrated virus suspension (105.5LD50) while they appeared late in mice inoculated with diluted virus suspension (100 LD50). After inoculation with U.V. inactivated virus no changes were seen. The results obtained in this study suggest that the vascular and microglial modifications are not related to a direct cytopathic effect of the virus but dependent on the amount of virus present in the central nervous system and linked to the virus DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688397
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  • 19
    Electronic Resource
    Electronic Resource
    Brain involvement in Whipple's disease (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 275-278 
    Details
    ISSN: 1432-0533
    Keywords: Whipple's disease ; Macrophage ; Electron microscopy ; Brain involvement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A man of 22 with Whipple's disease suffered from an acute febrile state and unconsciousness. Focal inflammatory lesions accompanied by large numbers of peculiar macrophages occurred in thalamus and basal ganglia. The electron microscopic findings conform to previous reports on brain involvement in Whipple's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688400
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  • 20
    Electronic Resource
    Electronic Resource
    GM2-Gangliosidosis, AB variant (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 207-226 
    Details
    ISSN: 1432-0533
    Keywords: GM2-Gangliosidosis, AB Variant ; Hexosaminidase A and B ; Electron microscopy ; Membranous cytoplasmic inclusions ; Zebra bodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Clinical and neuropathological studies of a case of AB variant GM2-gangliosidosis have been presented. The patient was a 14 months old black female infant who had “black cherry spot” in the retinas. The total activities of β-galactosidase and N-acetyl-β-hexosaminidase, as well as the proportion of hexosaminidase A and B components in her serum and leukocytes were normal when the assays were carried out with artificial fluorogenic substrate. Diagnosis of GM2-gangliosidosis AB variant was established by an abnormal increase of GM2-ganglioside in the biopsied brain tissue, similar to classical Tay-Sachs disease. Her clinical manifestation appeared to be similar but somewhat milder than those of classical Tay-Sachs disease. Light microscopic features of the cerebral biopsy were also closely similar to Tay-Sachs disease and Sandhoff disease but gliosis and neuronal loss were less pronounced. Electron microscopic study revealed numerous membranous cytoplasmic bodies (MCB) and zebra bodies in neurons. In addition, varieties of large intracytoplasmic inclusions in astrocytes, a feature distinctly different from classical Tay-Sachs disease, were observed. Numerous cytoplasmic inclusions were also present in oligodendroglia, pericytes and microglial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688395
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  • 21
    Electronic Resource
    Electronic Resource
    Formation and nature of swirl defects in silicon (1975)
    Springer
    Applied physics 8 (1975), S. 319-331 
    Details
    ISSN: 1432-0630
    Keywords: Self-interstitials in silicon ; Swirls ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Point defect agglomerates in dislocation-free silicon crystals, usually called “swirls”, have been investigated by means of high-voltage electron microscopy. It was found that a single swirl defect consists of a dislocation loop or a cluster of dislocation loops. By contrast experiments it could be shown that these loops are formed by agglomeration of self-interstitial atoms. Generally the loops have a/2〈110〉 Burgers vectors, but in specimens with high concentrations of carbon (∼1017 cm−3) and oxygen (∼1016 cm−3) also dislocation loops including a stacking fault were observed. In crystals grown at growth rates higher thanv=4 mm/min no swirls are observed; lower growth rates do not markedly affect the size and shape of the dislocation loops. With decreasing impurity content (particulary of oxygen and carbon) the swirl density decreases, whereas the dislocation loop clusters become larger and more complex. A model is presented which describes the formation of swirls in terms of agglomeration of silicon self-interstitials and impurity atoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00898366
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  • 22
    Electronic Resource
    Electronic Resource
    Vinblastine-induced ultrastructural changes in perisinusoidal cells of the rat liver (1975)
    Springer
    Research in experimental medicine 165 (1975), S. 245-249 
    Details
    ISSN: 1433-8580
    Keywords: Vinblastine ; Liver ; Perisinusoidal cell ; Microtubules ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Vinblastine, given intravenously to rats, leads to disappearance of microtubules, formation of paracrystalline inclusions and accumulation of fat droplets in the cytoplasm of the perisinusoidal cells of the liver suggesting that microtubules of the perisinusoidal cells play a role in lipid metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971384
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  • 23
    Electronic Resource
    Electronic Resource
    Production and fates of unique organelles (transosomes) in ovarian follicles of Gallus domesticus under various conditions. II (1975)
    Springer
    Cell & tissue research 163 (1975), S. 63-79 
    Details
    ISSN: 1432-0878
    Keywords: Avian follicles ; Oocytes ; Transosomes ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Production and fates of transosomes (sacs of ribosomes made in the follicular cells of an ovarian follicle and subsequently passed to the cytoplasms of the oocyte) have been studied by electron microscopy in ovaries of young chicks, a testosterone-treated hen, aged hens which had ceased laying eggs and a “non-layer” mutant. Study was also made of “primitive yolk” (vacuoles present in both follicular cells and ooplasms of small follicles of normally laying hens). It was found that both transosomes and vacuoles of primitive yolk were present in small oocytes of young chicks, and “non-layer” mutants. However, the transosomes deep within the ooplasms were present within lysosomal vesicles in both of these instances and the vacuoles containing primitive yolk were patently abnormal in the “non-layer” mutant. Very few transosomes or primitive yolk vacuoles were present within the ooplasms of follicles from a testosterone-treated hen or from those of aged hens which were no longer laying. In both of these latter cases such bodies were present in the follicular cells. However, many transosomes were seen to be in the process of being lysed within the cytoplasms of these follicular cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218591
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  • 24
    Electronic Resource
    Electronic Resource
    Nerve ending specializations in the central ganglia of Planorbis corneus (1975)
    Springer
    Cell & tissue research 163 (1975), S. 99-110 
    Details
    ISSN: 1432-0878
    Keywords: Central neuropile ; Planorbis corneus ; Synapses ; Spinule complexes ; Varicosities ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The neuropile in the central ganglia of Planorbis corneus was studied by electron microscopy, using different fixatives. Several types of specialization were observed in the membranes of adjacent axonal processes, varying from only slight membrane thickenings to structures resembling desmosomes. Specialized structures similar to the ‘spinule complexes’ in mammalian brain are widely distributed in certain areas of neuropile. They consist of a small projection which invaginates a neighbouring neurone; the membranes are closely apposed and there is associated electron-dense material. The problem of identifying chemical synapses in this tissue is discussed. Many axonal processes are varicose, and it is suggested that varicosities may also be sites of transmitter release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218593
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  • 25
    Electronic Resource
    Electronic Resource
    The membrane systems of the cardiac muscle cell of Cirolana borealis Lilljeborg (Crustacea, Isopoda) (1975)
    Springer
    Cell & tissue research 163 (1975), S. 175-184 
    Details
    ISSN: 1432-0878
    Keywords: Cardiac sarcomeres ; Circolana borealis (Isopod) ; T-tubules ; Sarcoplasmic reticulum ; Couplings ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The membrane systems of the cardiac muscle cell of the isopod Cirolana borealis Lilljeborg are described. The sarcolemma invaginates at the level of the Z band, forming transverse tubules. Narrow tubules branch off in a longitudinal direction from these transverse and radially arranged TZ-tubules forming a transverse collar at each A-I level, where dyadic and triadic junctions are formed with the sarcoplasmic reticulum. Two different orientations of the coupling discs have been detected in the supercontracted sarcomere, and this observation has been discussed. Adjacent myofibrils are separated by a double layer of sarcoplasmic reticulum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221725
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  • 26
    Electronic Resource
    Electronic Resource
    Comparative histochemical and electron microscopic studies of the sinus and venous walls of the human spleen with special reference to the sinus-venous connections (1975)
    Springer
    Cell & tissue research 163 (1975), S. 519-533 
    Details
    ISSN: 1432-0878
    Keywords: Human spleen ; Sinus lining cells ; Pulp veins ; Histochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Sinus and venous walls of normal human spleens were studied with enzyme histochemical and electron microscopic methods. Particular attention was paid to the connections between sinuses and veins. Histochemically the sinus lining cells revealed a distinct naphthol-AS-acetate-esterase activity but no reaction for alkaline phosphatase. Venous endothelial cells were positive for the latter but negative for the former enzyme. In the sinusvenous junctional area there were no endothelial cells with reactivity for both enzymes. Electron microscopically both the sinus lining cells and the venous endothelial cells could be clearly characterized and therefore easily distinguished from one another on morphological grounds. There were no clear ultrastructural indications of transitional forms between sinus lining cells and venous endothelial cells in the sinus-venous area. According to these findings, sinus lining cells represent a specialized endothelium, but one with practically no morpholgical similarities to the venous endothelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218497
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  • 27
    Electronic Resource
    Electronic Resource
    The fine structure of the epidermis of two species of salmonid fish, the Atlantic salmon (Salmo salar L.) and the brown trout (Salmo trutta L.) (1975)
    Springer
    Cell & tissue research 163 (1975), S. 535-543 
    Details
    ISSN: 1432-0878
    Keywords: Epidermis ; Salmonids ; Mucous cells ; Mucus ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The fine structure of epidermal mucous cells of two species of salmonid fish has been described. Mucous cells are, next to filament-containing cells, the most commonly encountered cells in fish epidermis. The development of the cells as they progress to the periphery has been characterised. They are initially difficult to distinguish from filament-containing cells: later, they can be recognised by the presence of much smooth-surfaced E.R. The mucigenesis and the subsequent secretion of mucus has been observed and it is essentially comparable to that which occurs in the mucous cells of the mammalian intestine. The mucous layer of the epidermal surface seems to mainly comprise of the products of these mucous cells and the “cuticle” seen in other species has not yet been observed in the salmonid species investigated here.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218498
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  • 28
    Electronic Resource
    Electronic Resource
    Thick filaments in vertebrate smooth muscle (1975)
    Springer
    Cell & tissue research 156 (1975), S. 201-216 
    Details
    ISSN: 1432-0878
    Keywords: Smooth muscle ; Myofilaments ; Vas deferens ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Smooth muscle cells of the mouse vas deferens fixed with 5% glutaraldehyde contained three types of filaments, namely, thin (50–80 Å) filaments, intermediate (100 Å) filaments and thick (120–180 Å) filaments. However, in 2 out of 16 experiments, under identical conditions, the cells did not contain thick filaments. With OsO4 fixation, thin filaments were not prominent, the most obvious being thick (120–250 Å) and intermediate (100 Å) filaments. After soaking in a modified Ringer solution under no applied tension for one hour, thick filaments (120–180 Å) appeared prominently in smooth muscle cells of the mouse vas deferens and thin filaments were in ordered bundles. By 4 hours, thick filaments had increased in size and density, with thin filaments distributed randomly around them. After 8 hours in Ringer, thin filaments were diffuse and difficult to discern, while thick filaments were large (up to 300 Å) and electron-dense. Intermediate (100 Å) filaments were present in association with dark bodies. Physiological experiments indicated that the intracellular components responsible for the development of a mechanical response were still functional at this time. The presence of “thick filaments” is also reported in degenerating smooth muscle cells of the guinea-pig vas deferens in tissue culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221803
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  • 29
    Electronic Resource
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    The differentiation of the acrosome in the spermatid of the budgerigar (Melopsittacus undulatus) (1975)
    Springer
    Cell & tissue research 156 (1975), S. 411-416 
    Details
    ISSN: 1432-0878
    Keywords: Acrosome ; Spermatid ; Budgerigar ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The development of the acrosome of the budgerigar spermatid was studied under the electronmicroscope. The acrosome arises from a granule derived from the Golgi apparatus which interacts with the nucleus to form a cone shaped acrosomal cap and a perforatorium. A quantity of cytoplasm and plasma membrane is captured from the cell periphery and incorporated into the substance of the acrosome. The possible significance of the developmental phases and comparative avian spermatology is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225369
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  • 30
    Electronic Resource
    Electronic Resource
    Intranuclear and cytoplasmic annulate lamellae in grasshopper spermatocytes (Genus Melanoplus) (1975)
    Springer
    Cell & tissue research 156 (1975), S. 475-482 
    Details
    ISSN: 1432-0878
    Keywords: Annulate lamellae ; Spermatocytes ; Grasshoppers ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Intranuclear and cytoplasmic annulate lamellae were studied in grasshopper spermatocytes (Melanoplus) with the electron microscope. Although cytoplasmic annulate lamellae were observed in all three species examined, intranuclear annulate lamellae were found in only one species. The intranuclear annulate lamellae encompass certain nuclear material adjacent to the nuclear envelope forming a vesicle that is extruded into the spermatocyte cytoplasm. In this same species, cytoplasmic annulate lamellae are seen contiguous with granular masses of varying size. These structures were noted as being morphologically indistinguishable from the “yolk nuclei” of dragonfly oocytes (Kessel and Beams, 1969; Kessel, 1973).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225107
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  • 31
    Electronic Resource
    Electronic Resource
    The fine structure of the iris of the grass frog, Rana pipiens (1975)
    Springer
    Cell & tissue research 158 (1975), S. 111-120 
    Details
    ISSN: 1432-0878
    Keywords: Iris ; Rana pipiens ; M. dilatator, sphincter pupillae ; Electron microscopy ; Photosensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The iris of the grass frog Rana pipiens, can respond to light even when isolated from the remainder of the animal. The iris is a three-layered structure, comprising a stromal layer and two layers of pigment epithelium. The sphincter pupillae, which is composed of pigmented smooth muscle cells, is embedded between the two layers of pigment epithelium. There is no dilator pupillae in this species. We have been unable to find any cells or any organelles in the iris which are anatomically specialized for photoreception in any obvious way.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219954
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  • 32
    Electronic Resource
    Electronic Resource
    Ultrastructural study of crystalloids in Sertoli cells of the normal, intersex and experimental cryptorchid swine (1975)
    Springer
    Cell & tissue research 158 (1975), S. 205-213 
    Details
    ISSN: 1432-0878
    Keywords: Sertoli cell ; Crystalloid ; Swine ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Spindle or needle-shaped crystalloids are observed in Sertoli cells of the intersex and experimental cryptorchid swine in the light and electron microscopes. Small crystalloids are also observed in Sertoli cells of the normal swine only by electron microscopy. These crystalloids consist of fine filaments. The filaments are about 5 nm in diameter and arranged parallel to the long axis of the crystalloid. In cross sections of the crystalloid, the close packing of the filaments shows hexagonal arrays. The interfilamentous distance is about 5 nm. In all animals examined, bundles of short filaments, which are 5 nm in diameter, are observed in the basal part of the Sertoli cells. Ultrastructural similarities among the crystalloids, the bundles of fine filaments, and the filamentous layer in the junctional specialization of the Sertoli cell are shown. These morphological similarities suggest that the crystalloids are formed by the aggregation of the bundles in the Sertoli cells of azoospermic testes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219961
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  • 33
    Electronic Resource
    Electronic Resource
    Masthead (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020101
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  • 34
    Electronic Resource
    Electronic Resource
    News (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. vii 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020114
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  • 35
    Electronic Resource
    Electronic Resource
    Masthead (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020201
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  • 36
    Electronic Resource
    Electronic Resource
    Mass spectra of spirostanol and furostanol glycosides (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 65-77 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electron impact mass spectra of twenty acetates and methylates of spirostanol and related furostanol glycosides of high molecular weight (above 650) have been investigated, and the most probable fragmentation patterns of the glycoside derivatives are presented. High resolution mass spectrometry provides useful information concerning the structures of both aglycone and sugar moieties as well as the molecular size of the oligoglycosides.
    Additional Material: 21 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020202
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  • 37
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    Identification of alkaloids; The condensation products of biogenic amines with formaldehyde, enzymatically formed from 5-methyltetrahydrofolic acid (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 15-22 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The use of thin-layer chromatography has demonstrated that incubations of indoleamines with 5-methyl[14C]tetrahydrofolic acid and an enzyme previously described as an N-methyltransferase, do not yield Nω, N1 or O-methylated products. Further elucidation by thin-layer chromatography, gas chromatography, mass spectrometry and selected ion monitoring enabled us to identify the reaction products as tetrahydroisoquinolines and tetrahydro-β-carbolines in mixtures incubated respectively with catecholamines and indoleamines in the presence of 5-methyl[14C]tetrahydrofolic acid and enzyme. The alkaloids have been shown to originate from a spontaneous condensation of the corresponding amines with formaldehyde, this latter being formed in the first stage of the reaction by enzymatic conversion from 5-methyltetrahydrofolic acid.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020105
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  • 38
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    Characterization of N-succinyl metabolites of adenine and aminoimidazole carboxamide by mass spectrometryAICA = N-(5-amino-4-imidazole)carboxamide; AICA ribonucleoside = N-(5-amino-1-ribosyl-4-imidazole)carboxamide; AICA ribonucleotide = N-(5-amino-1-ribosyl-4-imidazole)-carboxamide-5′-phosphate; S-AICA ribonucleoside = N-(5-amino-1-ribosyl-4-imidazole carbonyl)-L-aspartic acid; S-AICA ribonucleotide = N-(5-amino-1-ribosyl-4-imidazole carbonyl)-L-aspartic acid 5′-phosphate; S-AMP = N6-(2-succinyl)adenosine 5′-phosphate; S-adenosine = N6-(2-succinyl)adenosine; S-adenine = N6-(2-succinyl)-adenine. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 90-96 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: N6-(2-succinyl)adenosine 5′-phosphate and N-(5-amino-1-ribosyl-4-imidazole carbonyl)-L-aspartic acid ′-phosphate were prepared enzymatically using adenylosuccinate lyase (EC 4.3.2.2) isolated from human erythrocytes. N6-(2-succinyl)adenosine 5′-phosphate, N-(5-amino-1-ribosyl-4-imidazole carbonyl)-L-aspartic acid 5′-phosphate and N-(5-amino-1-ribosyl-4-imidazole carboxamide) 5′-phosphate and the nucleoside and free base analogs of these nucleotides were converted to the trimethylsilyl derivatives and characterized by mass spectrometry. The extent of the trimethylsilylation was greater for adenine substituted compounds compared with those related to aminoimidazole carboxamide. Major mass spectral fragment ions correspond to the intact base plus portions of the sugar skeleton and to electron impact-induced decomposition products of the sugar moiety. Succinyl substitution at N6 of the adenine derivatives leads to characteristic loss of CO2 SiMe3 from the molecular ion. A combination of liquid chromatographic procedures and gas chromatography mass spectrometry gave rapid and unequivocal identification of succinyladenine from human urine.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020205
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  • 39
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    Electronic Resource
    High resolution field desorption mass spectrometry by peak matchingContribution No. 2246. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 112-114 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We have used peak matching to accurately determine the molecular masses of field desorbed ions. A major advantage over high resolution photoplate recording is that it reduces analysis time without reducing accuracy or sensitivity. Molecular ions of nonvolatile and thermally labile compounds can be mass measured by this technique.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020208
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  • 40
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    Masthead (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020301
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  • 41
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    Mass spectrometric anaysis of urinary nitrogen from growth hormone deficient children administered glycine- 15N+ (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 117-120 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Five children deficient in growth hormone were treated with oxandrolone and human growth hormone. Average nitrogen retained was calculated from nine day balance data. During some balance periods, nitrogen retention was calculated by determination of 15N labeled glycine, as reported in this article. Twenty milligrams of 15N in excess of the natural abundance was administered orally. Urines were collected prior to, as well as after, administration of glycine-15 N and were analyzed for 15N by mass spectrometry. The percentage of 15N ranged up to 0.449% for collection over a 24 hour period, compared with 0.364% from control samples without excess 15N. These 15N data, like those from nitrogen balance, show the stimulating effects of oxandrolone and human growth hormone in the group as a whole.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020302
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  • 42
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    A microtechnique for the identification of diterpene ester inflammatory toxins (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 126-130 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method is described for the micro-identification of both mono- and diesters of 12-deoxyphorbol based upon a combination of thin-layer chromatography and mass spectrometry. The technique may be used on as little as 5 ml of fresh plant latex. Nine thin-layer systems are described, six of which are adsorption systems based on silica gel or alumina as adsorbent, and three are partition systems using diethyleneglycol as stationary phase. The migration by means of thin-layer chromatography is dependent upon the chain length of the C-13 esterifying acid and on the presence or absence of a free primary hydroxyl group at C-20. By means of mass spectrometry it was possible to confirm the identity of the esterifying moiety at both the C-13 and C-20 positions of 12-deoxy-4βOH-phorbol.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020304
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  • 43
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    2-ethyl-3-deuterohydracrylic acid, the major urinary metabolite of 2-trideuteromethylbutyric acid by a new metabolic pathway (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 133-136 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The urinary excretion by rats of predominantly 2-ethyl-3-deuterohydracrylic acid is a consequence of the intraperitoneal injection of 2-trideuteromethylbutyric acid. A significant fraction of the loading acid also is excreted unchanged. These results support the proposal of an alternate minor pathway of isoleucine catabolism and suggest that the corresponding catabolites in the minor and major pathways, 2-ethylhydracrylic and 2-methyl-3-hydroxybutyric acids, respectively, have significantly different subsequent metabolism.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020306
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  • 44
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    News (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. xi 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020210
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  • 45
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    Field desorption mass spectra of the peptides Pro-Leu-Gly-NH2, Cbz-Gly-Pro-Leu-Gly-Pro and bradykinin (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 121-125 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Field desorption mass spectra of a tripeptide Pro-Leu-Gly-NH2, a pentapeptide Cbz-Gly-Pro-Leu-Gly-Pro and a nonapeptide Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg are presented. In each case, a [M]+· or [M + 1]+ peak of the peptide is obtained. Sufficient fragmentation of the peptide backbone occurred to allow sequence determination of all three peptides. The pentapeptide produced [M]+·, [M + 1]+ and [M + 2]+· ions which also included molecules of ethylacetate, ethanol and/or water bound to the ion.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020303
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  • 46
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    A method for mass range specific gas chromatographic detection in gas chromatography mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 131-132 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method is described for continous mass range specific gas chromatographic detection using the β-slit of a reverse geometry double focusing mass spectrometer. The method has several advantages over total ion current detection, including elimination of the solvent peak from the detector trace and reduction of back ground noise due to column bleeding. The technique has been applied here to detect prostaglandins in biological samples.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020305
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  • 47
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    Isolation and characterization of some methanonaphthalene photoproducts (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 169-175 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The photodecomposition products of aldrin, dieldrin and endrin were investigated by means of gas chromatography mass spectrometry, nuclear magnetic resonance and infrared spectrophotometry. An alternate isomeric product of aldrin and four endrin analogs were encountered. The mass spectra of eight photoproducts are presented with direct inlet spectra of endrin aldehyde and endrin alcohol.
    Additional Material: 13 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020402
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  • 48
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    Mass spectral studies on prostaglandins. Prostaglandin A1 (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 190-196 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectroscopic behaviour of prostaglandin A1 and its methyl ester has been studied. Mechanisms are suggested for the majority of fragmentation processes occurring in the spectra of these compounds. The proposed mechanisms have been confirmed by low electron voltage spectra, measurements on metastable ion decompositions, high resolution mass measurements and deuterium labelling.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020405
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  • 49
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    Mass-fragmentography of nanogram quantities of biogenic amine metabolites in human cerebrospinal fluid and whole rat brainAbbreviations: PFPA = pentafluoropropionic anhydride; PFPI = pentafluoropropionic imidazole; VMA = vanilmandelic acid; ME/PFP = methyl ester/pentafluoropropionyl; DOPAC = dihydroxyphenylacetic acid; HVA = homovanillic acid; PHPA = p-hydroxyphenylacetic acid; PHMA = p-hydroxymandelic acid; MHPG = 3-methoxy-4-hydroxyphenylglycol; MHPE = 3-methoxy-4-hydroxyphenyl ethanol. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 183-189 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A mass fragmentographic method is described for the simultaneous assay of both the acidic and alcoholic metabolites of tyramine, octopamine, dopamine and norepinephrine. The method was successfully applied for the measurement of nanogram quantities of these metabolites in human ventricular and lumbar cerebrospinal fluids and in the rat brain. Mass fragmentography was carried out on the methyl ester/pentafluoroproprionyl derivatives of the acidic and the pentafluoropropionyl derivatives of the alcoholic metabolites, employing an 8 ft 3% SE-54 column. Chemical methods for the synthesis of a number of deuterated isomers (isotopomers) of the above metabolites are also described. These isotopomers were utilized as internal reference standards for the assay of the metabolites in biological materials. They were also used to study the fragmentation reactions of these metabolite derivatives.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020404
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  • 50
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    Metabolites of phencyclidine in humans (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 204-205 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A N-dealkylated metabolite, 1-phenylcyclohexylamine, was detected in a urine sample of a patient who had ingested phencyclidine. The identification was facilitated by a feeding experiment using a mouse administered a 1:1 mixture of unlabeled and phenyl-d5-labeled drug. A control experiment was also performed in which a mouse was fed only the unlabeled drug. Two hydroxylated metabolities were also identified in human urine samples. One of the hydroxylated metabolites has a hydroxy group located at the piperidine moiety of phencyclidine while the other has the hydroxy group located at the cyclohexane ring of the drug. It was also shown that 1-phenyl-cyclohexene detected in the human samples, was an artifact which arose from pyrolysis of phencyclidine during gas chromatography.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020408
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  • 51
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    Letter to the Editors (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 225-225 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020412
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  • 52
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    Thin-layer chromatography and high resolution selected ion monitoring for the analysis of C19 steroids in human hyperplastic prostate tissue (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 219-224 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Interfering nonpolar lipid material was removed from the acetone extracts of several samples of benign hyperplastic prostate tissue. Endogenous steroids were separated by preparative thin-layer chromatography into fractions containing testosterone, 5α-dihydrotestosterone and the 5α-androstane-3, 17-diols, and concentrations of these steroids were measured by molecular ion monitoring of suitable derivatives at a resolution of 8500 to 10 000 during combined gas chromatography mass spectrometry. The sensitivity and specificity of this procedure allowed unequivocal detection of the steroids of interest at the femtomole level and the incorporation of epimers as internal standards enabled accurate quantitative measurements. The results indicated that 5α-dihydrotestosterone is usually the most predominant of the steroids measured, and that of the 5α-androstanediols, only the 3α, 17β and 3β, 17β isomers occur in measurable concentration, with the former usually predominant.
    Additional Material: 6 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020411
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  • 53
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    Isolation and characterization of some methanoindene photoproducts (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 176-182 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ultraviolet irradiation of the methanoindene compounds chlordene, 1-hydroxychlordene cis- and trans-chlordane, trans-nonachlor and heptachlor using acetone as the sensitizing solvent yielded caged photoisomers. Electron impact spectra of twelve photoproducts are reported. Structural assignments based on nuclear magnetic resonance, infrared and gas chromatography data are reported for the major photoproducts.
    Additional Material: 14 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020403
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  • 54
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    Report on the workshop sponsored by the committee for biological applications at the 23rd annual conference of the American society for mass spectrometry, Houston, May 1975 (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 227-227 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020415
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  • 55
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    C-methylation: An artifact in peptides derivatized for sequencing by mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 254-260 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The extent of C-methylation, an artifact of the permethylation procedure used to derivatize peptides for mass spectrometric sequencing, was investigated by mass spectrometry. Ten glycine-containing peptides were N-acetylated and then permethylated by the Hakomori method and analyzed by chemical ionization and, in some cases, by electron ionization mass spectrometry. A comparative study was made of the tripeptides Gly Pro Ala and Ala Pro Gly, derivatized by three permethylation procedures. The results show that while C-methylation occurs primarily at glycine, other amino acids (Gln, Glu, Met, Tyr) are also C-methylated, but to a lesser degree. The extent to which C-methylation occurs varies widely and depends on residue position and on the identity of neighboring residues. Such artifacts could lead to serious errors in peptide sequences determined by mass spectrometry, especially when mixtures of peptides are analyzed.
    Additional Material: 4 Tab.
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    URL: http://dx.doi.org/10.1002/bms.1200020503
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  • 56
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    Biotransformation of cannabinoids by Syncephalastrum racemosumAbbreviations: THC = tetrahydrocannabinol; CBN = cannabiol; CBD = cannabidiol. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 266-271 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Incubation of four common cannabinoids with vegetative cultures of the fungus Syncephalastrum racemosum yielded a number of polar metabolites. Major metabolites of Δ9-tetrahydrocannabinol, Δ8-tetrahydrocannabinol, cannabidiol and cannabinol were eluted from preparative thin-layer chromatographic plates and analyzed by gas-liquid chromatography mass spectrometry. The mass spectrum of each of the compounds examined showed a molecular ion corresponding to a monohydroxylated derivative of the parent cannabinoid. Identification of the major metabolite of each cannabinoid as the product of hydroxylation in the penultimate (4′) position of the n-pentyl sidechain was made by analysis of the mass spectra of underivatized and TMS derivatized metabolites and by comparison with model compounds. A number of prominent fragment ions in the mass spectra were identified as arising through known fragmentation pathways of cannabinoids.
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020505
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  • 57
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    Pressure measurement in the chemical ionization source of a Du Pont 21 490-B mass spectrometer (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 279-280 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A pressure measuring probe has been built for the chemical ionization source of a Du Pont 21 490-B mass spectrometer. The probe fits exactly in the place of the solid sample probe and, when connected to a Baratron manometer, enables pressure measurement directly in the source. This can be used to calibrate an ionization gauge connected to the source housing or a manometer in the reagent gas inlet line. The probe has been used to determine the maximum source pressure attainable for various reagent gases in the Du Pont 21 490-B mass spectrometer.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020508
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  • 58
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    Erratum (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 284-284 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020510
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  • 59
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    News (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. viii 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020511
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  • 60
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    Forthcoming events (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. x 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020512
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  • 61
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    Determination of a mannose-containing trisaccharide in the urine of patients and heterozygotes of mannosidosis (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 285-287 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method employing gas-liquid chromatography and combined gas-liquid chromatography mass spectrometry was developed for the quantitative determination of α-D-mannopyranoside-(1 → 3)-β-D-mannopyranoside-(1 → 4)-2-acetamido-2-deoxy-D-glucose in urines. The concentration of this trisaccharide varied between 123 and 469 mg per litre of urine in the patients with mannosidosis but was not detected in twenty normals and two heterozygotes.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020602
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  • 62
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    The identification of 6-methoxy 8-aminoquionoline as a metabolite of primaquine in man (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 304-306 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The identification of 6-methoxy 8-aminoquinoline as a metabolite of Primaquine, an important antimalarial drug, is described. The metabolite is present in urine, plasma and erythrocytes following drug ingestion. It was identified by mass fragmentography of its 1H and 2H acetate and the acetate produced from authentic material. No evidence of further metabolites was obtained.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020605
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  • 63
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    Field desorption mass spectra of rifamycinsPaper communicated at the American Society for Mass Spectrometry, 23rd Annual Conference on Mass Spectrometry and Allied Topics, Houston, Texas, 25th to 30th May 1975. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 307-312 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The field desorption mass spectra of eight rifamycins were obtained and compared with their electron impact mass spectra. All the compounds gave abundant molecular or quasimolecular ions, while no significant fragmentation was observed in the low mass region of the spectra. Therefore, field desorption mass spectrometry has been shown to be of great importance for the determination of the molecular weight of these antibiotics.
    Additional Material: 9 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020606
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  • 64
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    Polypeptide sequencing by a gas chromatograph mass spectrometer computer system: II - characterization of complex mixtures of oligopeptides as trimethylsilylated polyamino alcoholsA1, A2,… ions corresponding to the N-terminal amino acid, dipeptide… in the peptide derivatives used (polyamino alcohol-OTMS-ethers). Z1, Z2 … ions corresponding to the C-terminal amino acid, dipeptide … in the peptide derivatives used. R … sidechain of amino acids (as derivatized). Δ, contribution of amino acids to the retention index value of a derivatized peptide molecule. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 326-339 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Complex mixtures of O-trimethylsilylated polyamino alcohols, which have been generated by either acid or enzymatic hydrolysis of polypeptides and subsequent derivatization, are completely characterized by a gas chromatograph mass spectrometer computer system. These peptide derivatives possess excellent gas chromatographic properties; a wide range of derivatives from di- to hexapeptides may be separated in a single chromatographic experiment. The identification of these compounds, either manually or with the assistance of the computer, is based on three sets of data which are automatically generated after the g.c.m.s. computer experiment: (1) mass spectra, which exhibit sequence-determining ions of high abundance; (2) selected ion records, which allow efficient location of peptide derivatives in the gas chromatogram as well as resolution of incompletely separated fractions; (3) retention indices, which can be calculated from values which have been assigned to each amino acid residue.
    Additional Material: 7 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020608
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  • 65
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    Editorial (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 1-1 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020102
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  • 66
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    Plasma amino acid analysis by isotope ratio gas chromatography mass spectrometry computer techniquesTAB = N-trifluoroacetyl n-butyl ester; NBTMS = N-neopentylidine n-butylester trimethylsilyl ether; TCA = trichloroacetic acid; EGA = ethylene glycol adipate. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 9-14 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A routine analysis for micro samples of plasma amino acids by a gas chromatography mass spectrometry computer system has been developed. Isotope ratio determination was used as the quantitating technique via multiple internal standards. The speed of the analysis is increased by omitting the ion exchange purification step and its flexibility is maximized by using repetitive scanning rather than selective ion monitoring. This procedure yields excellent precision and accuracy, as demonstrated by the analysis of a known amino acid mixture and of neonatal plasma.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020104
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    The rapid identification of a new metabolite of warfarin via a chemical ionization mass spectrometry ion doublet technique (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 23-30 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An ion doublet chemical ionization mass spectrometry technique was utilized for the rapid detection and elucidation of the structure of a new hydroxylated metabolite of the oral anticoagulant warfarin. This technique involves the use of a 50:50 mixture of stable isotope labeled and unlabeled drug. With this procedure ions found in the mass spectrum which are associated with the administered drug can be identified unambiguously. The unknown metabolite from rat liver microsomal preparations was identified as benzylic hydroxywarfarin by reincubating the microsomes with warfarin specifically labeled in the benzylic position and observing the subsequent loss of label in the product. The ion doublet technique was also employed in a single human study, and benzylic hydroxywarfarin was detected and identified.
    Additional Material: 5 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020106
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    The mass spectra of permethylated oligosaccharides (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 36-45 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electron impact mass spectra of permethyl ethers of twenty-five highly purified oligosaccharides, containing first, aldohexose units only and second, at least one fructose unit, have been determined. It is concluded that spectra of these derivatives can yield considerable structural information, especially in relation to the detection of fructose units, the pyranose/furanose ratio and the position of the glycosidic linkage, and are to be preferred from this point of view to the mass spectra of trimethylsilyl ethers.
    Additional Material: 8 Tab.
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    URL: http://dx.doi.org/10.1002/bms.1200020108
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  • 69
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    Species differences in the metabolism of α-1-trans-4-dimethylaminotetrahydro-3-furylcyclohexanephenylglycolate, an experimental anticholinergic agent (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 53-58 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Metabolism studies in the rat, dog and cat have demonstrated a definite species difference in biotransformation and elimination of α-1-trans-4-dimethylaminotetrahydro-3-furylcyclohexanephenylglycolate (Lilly 82537), an experimental anticholinergic agent. Separation and identification of urinary and biliary metabolites by gas chromatographic mass spectrometric analysis has shown three mechanisms to be involved in the metabolism of Lilly 82537 in these species; N-demethylation, aliphatic hydroxylation and ester hydrolysis. A major portion of the drug administered was eliminated unaltered in the cat and dog, while only trace quantities of parent drug were observed in the urine and bile of rats. These metabolic differences may be responsible for observed species differences in the pharmacologic activity of Lilly 82537.
    Additional Material: 5 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020110
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    A reproducible gas chromatographic mass spectrometric assay for low levels of methylphenidate and ritalinic acid in blood and urineMEPPA = methylphenidate: HPPA = ritalinic acid. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 2-8 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A rapid, sensitive method of analysis for methylphenidate and ritalinic acid in blood and urine has been developed using gas chromatography mass spectrometry and selected ion monitoring for separation and detection. The methylphenidate is isolated by solvent extraction into chloroform and the ritalinic acid is isolated by salting out into isopropyl alcohol, followed by methylation and subsequent solvent extraction. The method has been applied to the study of methylphenidate metabolism and excretion in adults and hyperactive children under-going treatment with methylphenidate.
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020103
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  • 71
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    Electron impact mass spectral studies of hydrazine monoamine oxidase inhibitor drugs (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 82-89 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Identification of hydrazine monoamine oxidase inhibitor drugs such as isoniazid, iproniazid, nialamide, isocarboxazid and iproclozide is made by electron impact mass spectrometry using the direct insertion technique. The molecular ion itself, although of low relative abundance, is found in the mass spectra of all compounds studied. Relative intensities of the major fragments and data on metastable ions useful in the identification of these compounds are reported. With the aid of synthesized structurally related products, deuterium labelling of exchangeable hydrazidic and hydrazinic protons and by the use of hexadeuterated isopropylic analogues, detailed information about fragmentation patterns is obtained. Splitting processes are chiefly governed by the nature of the aromatic substituent at the hydrazidic end and the alkyl sidechain located at the second hydrazinic nitrogen. The major fragmentations occurring are loss of small neutral molecules, double rearrangement, cleavage of the N—N bond, amide bond rupture, β-cleavage to the hydrazinic nitrogen atom and McLafferty rearrangements.
    Additional Material: 1 Tab.
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    URL: http://dx.doi.org/10.1002/bms.1200020204
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  • 72
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    The application of quadrupole mass filters in field desorption mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 31-35 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The advantages and limitations which quadrupole mass filters afford to the field desorption technique with respect to use for routine work are discussed and experimentally confirmed by the analyses of some drugs using a field desorption quadrupole mass spectrometer. The possibility of fast identification of drug intoxication is demonstrated by the analysis of the chloroform extract of urine in a case of overdose of hypnotics.
    Additional Material: 5 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020107
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  • 73
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    Letters to the editors (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 59-62 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020111
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  • 74
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    Report on the first annual field desorption spectrometry workshop, university of illinois, 16th to 17th december 1974 (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 63-64 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020112
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  • 75
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    Forthcoming events (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 64-64 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020113
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  • 76
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    Isolation and mass spectral identification of blood metabolities of cyclophosphamide: Evidence for phosphoramide mustard as the biologically active metaboliteNBP = 4-(p-nitrobenzyl)pyridine. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 46-52 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Thin-layer chromatography and mass spectrometry were used to isolate and identify cyclophosphamide metabolites present in blood of mice. Blood was removed 5, 15, 30 and 45 minutes after intraperitoneal administration and extracted with chloroform followed by methanol. Thin-layer chromatography of the two extracts and the residual solid with or without prior methylation, collection of resulting alkylating components, determination of radioactivity and mass spectral analysis, served to identify cyclophosphamide, 4-ketocyclophosphamide, alcophosphamide, N-dechloroethylcyclophosphamide, carboxyphosphamide, phosphoramide mustard and nor-HN2. The absence of detectable levels of 4-hydroxycyclophosphamide or aldophosphamide in the blood of cyclophosphamide-treated mice suggests that cyclophosphamide is converted rapidly in the liver to carboxyphosphamide, 4-ketocyclophosphamide, phosphoramide mustard and nor-HN2. Direct administration of synthetic 4-hydroxycyclophosphamide to mice and extraction of blood with chloroform demonstrated the recovery of this metabolite in vivo. Analysis of extracts of blood from mice treated with phosphoramide mustard indicated the presence of nor-HN2, 3-(2-chloroethyl)-1,3-oxazolidin-2-one and unchanged drug. Consideration of blood levels, cytotoxicity and alkylating activity of metabolites identified in, or inferred from, this study, implicates phosphoramide mustard as a leading candidate for the biologically active form of cyclophosphamide.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020109
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  • 77
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    A comparison of unlabelled and labelled internal standards for quantification by single and multiple ion monitoring (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 78-81 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Single and multiple ion monitoring is employed to evaluate whether deuteriomethylated allobarbitone or methylated quinalbarbitone is the better internal standard for quantifying methylated allobarbitone through a g.c.m.s. system based on a quadrupole mass spectrometer. It is shown that the coefficient of variation of the single ion monitoring method is substantially lower than that of the multiple ion monitoring method. Small quantities of a compound are therefore most accurately determined by adding a labelled version of the compound solely to act as a carrier, plus an internal standard giving an ion in common with the compound being measured. By this means 40 pg and 100 pg of methylated allobarbitone could be determined with coefficients of variation of 11.5 and 2.0%, respectively. Using only the labelled compound as internal standard, the corresponding values were 19.8 and 15.3% for the same quantities.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020203
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  • 78
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    Mass spectrometry of 1,4-benzodiazepines (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 97-106 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mass spectra and fragmentation pathways of some achiral and a number of chiral 1,4-benzodiazepine-2-ones, and those of their in vitro biotransformation products are reported and discussed. Various derivatives substituted in position 3 are shown to be useful for the determination of fragmentation pathways from low resolution spectra.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020206
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  • 79
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    The microsomal hydroxylation of aniline mustard-d3 [n, n-di- (2- chloroethyl) - 2,4,6-trideuterioaniline] (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 107-111 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The metabolism by rat liver microsomes of the 2,4,6-trideuterio derivative of aniline mustard [N, N-di-(2-chloroethyl)aniline] in admixture with unlabelled material, has been studied. The resulting p-hydroxy derivative was isolated and examined by mass spectrometry. The extent of migration of deuterium from the p- to the m-position, determined from the ratio of trideuteriated to dideuteriated product, was 46%, but the protium and deuterium forms were hydroxylated at the same rate (zero isotope effect).
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020207
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  • 80
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    Letter to the editors (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 115-115 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020209
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  • 81
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    Gas chromatographic mass spectrometric computer analysis of volatile components in blood plasma from hemodialysis patients (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 142-147 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Low molecular weight volatile organics extracted from the plasma of patients before and after hemodialysis were analyzed by high resolution capillary gas chomatographic mass spectrometric computer methods. The volatile components were collected on a polyphenyl ether solid adsorbent prior to analysis. Identification of components was achieved by mass spectrometry. Quantitaive changes were observed in both the plasma and dialysate composition with time. The method described provides a new means whereby the 100 or so low molecular weight organic volatiles of plasma can be monitored during the dialysis procedure.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020308
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  • 82
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    Chemical ionization mass spectrometry of quaternary amines (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 164-167 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chemical ionization mass spectra of eleven biomedically significant quaternary amimes are reported. The samples are converted to volatile compounds by known thermal decompositions. Chemical ionization of the compounds gives simple, easily identifiable spectra which are useful for the analysis of the original samples.
    Additional Material: 4 Tab.
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    URL: http://dx.doi.org/10.1002/bms.1200020311
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  • 83
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    News (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. ix 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020312
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  • 84
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    Masthead (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020401
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  • 85
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    A re-examination of the synthesis and some properties of the in vitro metabolite, N-hydroxyphenmetrazineAbbreviation: CPBA = m-chloroperbenzoic acid. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 137-141 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reported synthesis of N-hydroxyphenmetrazine from phenmetrazine by the action of m-chloroperbenzoic acid could not be repeated. When the synthetic procedure was modified N-hydroxyphenmetrazine was obtained in low yield. The product had different properties from those claimed previously, but was identical to metabolically produced N-hydroxyphenmetrazine. It was characterized by means of thin-layer chromatography, combined gas chromatography and mass spectrometry, preparation of a t-butyldimethylsilyl derivative and oxidation to a mixture of nitrones. Mass spectrometry was also used to characterize these derivatives.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020307
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  • 86
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    Sugar sequence analysis by mass spectrometry of a new saponoside isolated from the bark of Colubrina arborescens Mill (Rhamnaceae) (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 156-163 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mass spectrometry has revealed the sugar sequence of a new saponoside isolated from the bark of Colubrina arborescens Mill (Rhamnaceae). The branched trisaccharide moiety if this saponoside is shown to be and O-β-L-arabinopyranosyl (1 → 2gal)-O-β-D-glucopyranosyl (1 → 3gal)-galactopyranose located on an as yet unknown genin. Mass spectra are presented for the permethylated saponoside, a permethylated trisaccharide and a partially methylated disaccharide, i.e. 3-β-D-glucopyranosylgalactose (C2 — OH), derived by partial hydrolysis. Further characterization of the mono-, di- and trisaccharides involved NaBH4 and NaBD4 reduction of the 4,6-dimethylgalactose reducing sugar moiety, followed by acetylation or trimethylsilylation.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020310
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  • 87
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    Forthcoming event (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. xi 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020313
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  • 88
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    Gas chromatography mass spectrometry of trimethylsilyl ethers of sidechain hydroxylated Δ4-3-ketosteroids. Long range trimethylsilyl group migration under electron impactSystematic names: 1 = (25R)-5-cholestene-3β, 26-diol; 2 = (25R)-26-hydroxy-4-cholesten-3-one; 3 = 5-cholestene-3β,25-diol; 4 = 25-hydroxy-4-cholesten-3-one; 5 = (25RS)-27-nor-5-cholestene-3β,25-diol; 6 = (25RS)-25-hydroxy-27-nor-4-cholesten-3-one; 7 = (24RS)-5-cholestene-3β,24-diol; 8 = (24RS)-24-hydroxy-4-cholesten-3-one; 9 = (22RS)-5-cholestene-3β,22-diol; 10 = (22RS)-22-hydroxy-4-cholesten-3-one; 11 = (20R)-5-cholestene-3β,20-diol; 12 = (20R)-20-hydroxy-4-cholesten-3-one; 13 = 5-cholene-3β,24-diol; 14 = 24-hydroxy-4-cholen-3-one; 15 = 23,24-dinor-5-cholene3β,22-diol; 16 = 22-hydroxy-23,24-dinor-4-cholen-3-one; 17α-ethynyltestosterone = 17α-ethynyl-17β-hydroxy-4-androsten-3-one; 17α-methyl-1,2-didehydrotestosterone = 17β-hydroxy-17α-methyl-1, 4-androstadien-3-one. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 148-155 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electron impact mass spectrum (70 eV) of 26-trimethylsilyloxy-4-cholesten-3-one shows a base peak at m/e 196, attributable to combination of the trimethylsilyl group with a fragment of m/e 123 produced by cleavage across ring B. 18O labelling confirms that the fragment of m/e 196 contains the 3-oxygen atom, and 2H labelling indicates retention of the trimethylsilyl moiety. Similar ions are observed from other Δ4-3-ketones with sidechain trimethylsilyloxy groups: abundances depend on the site of substitution. The corresponding enol trimethylsilyl ethers are readily separable from the keto forms by gas-liquid chromatography, and afford mass spectra in which the molecular ions are abundant, while ions of m/e 196 are of only moderate intensity.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020309
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  • 89
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    Nomenclature discussions held at the third international symposium on mass spectrometry in biochemistry and medicine and the twenty-third annual conference of the American society for mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 226-226 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020414
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  • 90
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    Mass fragmentographic determination of unlabeled and deuterium labeled methadone in human plasma. Possibilities for measurement of steady state pharmacokinetics (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 197-200 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A mass fragmentographic method for simultaneous measurement of unlabeled and deuterium labeled methadone in human plasma is described. This specific method has a lower sensitivity of about 16 pmol/ml with a coefficient of variation of less than 4%. The usefulness of the method was evaluated in studies on opiate dependent subjects undergoing methadone maintenance treatment. In one application methadone-d3 was given as a pulse dose during continuous treatment with unlabeled methadone and plasma levels of both species followed by mass fragmentography. The method will be of value in the study of methadone pharmacokinetics in the steady state and in other in vivo situations where multiple drug pools must exist.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020406
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  • 91
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    Analysis of organochlorine metabolites in crude extracts by high resolution photoplate mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 201-203 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: High resolution photoplate mass spectrometry has been used to examine crude goat urine extracts to determine the fate of organochlorine xenobiotics in these animals. Using a direct introduction temperature controlled probe the crude urine extracts were analyzed and the presence of oxygenated metabolites of 4-chlorobiphenyl and 4,4′-dichlorobiphenyl were confirmed in goats; analyses of urine extracts from goats injected with the commercial Aroclor mixtures 1254 and 5460 confirmed the formation of oxygenated penta-, tetra- and monochlorobiphenyl metabolites and an oxygenated dichloroterphenyl metabolite, respectively. This technique was particularly useful in the analysis of complex mixtures of metabolites.
    Additional Material: 1 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020407
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  • 92
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    Mass spectrometric identification of some nonvolatile organic compounds (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 215-218 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Several slightly volatile or nonvolatile organic compounds were transformed directly in the solid sample inlet system into more volatile compounds by addition of an appropriate reagent to the sample. In this way, in several instances free organic acids could be obtained from their salts. A similar method was used to transform some amino acids into derivatives of diketopiperazine or of phthalic acid.
    Additional Material: 4 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020410
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  • 93
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    Forthcoming Meeting (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 225-225 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020413
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    Quantification of phencyclidine in body fluids by gas chromatography chemical ionization mass spectrometry and identification of two metabolitesPresented in part at the American Society for Mass Spectrometry, 23rd Annual Conference on Mass Spectrometry, Houston, Texas, May, 1975.Abbreviation: PCP = phencyclidine. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 206-214 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method has been developed for quantification of phencyclidine [1-(1-phenylcyclohexyl)piperidine] in body fluids using gas chromatography chemical ionization mass spectrometry with selected ion recording. Pentadeuterated phencyclidine was synthesized and used as the internal standard. In developing the method it was discovered that phencyclidine thermally fragments to 1-phenylcyclohexene at elevated temperatures. The sensitivity and specificity of the method permits determination of 1 ng of phencyclidine in 1 ml of body fluid. The concentrations of the drug in blood samples from five individuals, who ingested unknown quantities of phencyclidine, were found to range from 50 ng/ml to 2.7 μg/ml. Following intravenous administration of 1 mg of phencyclidine hydrochloride to a 12.5 kg dog, the blood concentration of the drug peaked at 17.6 ng/ml and exhibited a half-life of approximately one hour. Two metabolities of phencyclidine were detected in human and dog urine after enzymatic hydrolysis. The metabolities were tentatively identified as 4-phenyl-4-piperidinocyclohexanol and 1-(1-phenylcyclohexyl)-4-hydroxy-piperidine by electron impact and chemical ionization mass spectral analysis of the metabolites and their trimethylsilyl derivatives. Structural confirmation was achieved by synthesis of the metabolities. A third metabolite was found in urine from rhesus monkeys and was tentatively identified as 1-(1-phenyl-4-hydroxycyclohexyl)-4-hydroxypiperidine.
    Additional Material: 13 Ill.
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    URL: http://dx.doi.org/10.1002/bms.1200020409
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  • 95
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    News (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. vii 
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    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020416
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  • 96
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    Masthead (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975) 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020501
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  • 97
    Electronic Resource
    Electronic Resource
    Environmental applications of mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 229-253 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Publications from 1969 through 1974 reporting organic and spark source mass spectrometric studies on environmental samples have been compiled. Emphasis is placed on pollutants identified, but some methods and techniques are discussed. The 396 reports cited vary from those reporting hundreds of identified pollutants to those describing the analysis of only one sample containing one or a few pollutants. Reports concerning forensic, synthetic and standard samples, and analyses for drug residues, metabolites and degradation products are not included.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020502
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  • 98
    Electronic Resource
    Electronic Resource
    A pyrolysis gas chromatography mass spectrometry study of the actinomycete Streptomyces longisporoflavus (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 261-265 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Pyrolysis gas chromatography mass spectrometry studies of the whole lyophilized microorganism Streptomyces longisporoflavus, an actinomycete, are reported. Identification of the pyrolysis products indicate that the vast majority arise from protein and carbohydrate origin. There is a paucity of lipid fragments evident. Some of the details of its biochemical composition evident in these results are compared with our previous similar studies on the bacteria Micrococcus luteus and Bacillus subtilis var. niger and suggest this actinomycete lies in biochemical complexity somewhere between the latter two organisms. Although the pyrolysis patterns of these three organisms possess considerable similarities, they are drastically different to that from the fungus Aspergillus niger.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020504
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  • 99
    Electronic Resource
    Electronic Resource
    Synthesis and mass spectrometry of deuterium labelled melatonin (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 272-275 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Melatonin containing three deuterium atoms in the 5-methoxy position has been synthesized by methylation of N-acetylserotonin with dideuterodiazomethane. The deuterated product was characterized by mass spectrometry and found to contain 90.8% of maximum possible deuterium incorporation. The major fragmentation patterns of melatonin under electron impact ionization are discussed with the aid of high resolution, deuterium labelling and metastable transition data.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020506
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  • 100
    Electronic Resource
    Electronic Resource
    Mass spectrometry in toxicology: I - calculation of theoretical isotopic abundances and optimum ion dwell time for a 2,3,7,8-tetrachlorodibenzo-p-dioxin pharmacokinetic studyAbbreviation: TCDD = 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 276-278 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin-13C12 parent ion isotope cluster abundances are calculated on a multinomial probability basis for all possible isotope combinations. Parent negative ions \documentclass{article}\pagestyle{empty}\begin{document}$ \left[{\rm M} \right]^{\mathop - \limits_. } $\end{document} at m/e 322 and m/e 334 were selected for dual ion monitoring in the isotope dilution technique. Calculations, according to the Jaech's Method, are given for optimizing dual ion monitoring dwell time in the pulse counting mode at the femtogram level.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020507
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