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  • 1985-1989  (2,642)
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  • 1
    ISSN: 1573-0832
    Keywords: Sporotrichosis ; Sporothrix schenckii ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The isolation of Sporothrix schenckii from a female European cat it is described. The cat showed lengthened alopecic areas, with prominent nodules in the external surface of the thighs and abdomen. A mycological and histopathological studies of the lesions were carried out. The lesions resolved under treatment with 20% potassium iodide in doses of 0'1 ml/kg oral route in a 8 weeks period.
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  • 2
    ISSN: 1432-0568
    Keywords: Lateral reticular nucleus ; Cerebellar nuclei ; Retrograde transport of WGA-HRP ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cerebellar nuclear projection from the lateral reticular nucleus (NRL) was studied in 29 cats by means of retrograde axonal transport after implantation of the crystalline wheat germ agglutinin-horseradish peroxidase (WGA-HRP) complex in the cerebellar nuclei. It was confirmed that all the cerebellar nuclei receive afferent fibres from the NRL with the strongest termination in the ipsilateral interposed nuclei. In addition, these experiments give evidence of a previously unrecognized topical pattern in the projection to the interposed nuclei, arranged according to the same principle as in the projection to the immediately overlying cerebellar cortex. Thus, the anterior interposed nucleus receives fibres from all parts of the main NRL, its rostral part especially from laterally situated neurons, while subsequent more caudal parts from more medially situated neurons, while the posterior interposed nucleus receives fibres mainly from the dorsomedial part of the main NRL. The cerebellar nuclear projection to the NRL was investigated in 15 cats using retrograde transport after ventral microiontophoretical ejections of the WGA-HRP complex in the main NRL. The contralateral rostral fastigial nucleus was confirmed as the main origin of this projection, but projecting neurons were, in addition, discovered rostrally in the anterior interposed and dentate nuclei on the same side. No topical differences could be observed following ejections in different parts of the NRL; the majority of the projecting neurons were always concentrated along the ventral and lateral borders of the fastigial nucleus and in the adjacent medial part of the anterior interposed nucleus.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 79 (1989), S. 330-332 
    ISSN: 1432-0533
    Keywords: Sphingomyelinosis ; Neuropathology ; Histochemistry ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report presents the clinical, morphological and biochemical findings on an 11-month-old female Siamese cat with neurovisceral sphingomyelinosis. Gross pathological features and histochemical findings are compared with the human disease counterpart and the previously described animal models. Hepatomegaly was observed while splenomegaly was not. Although sphingomyelin in liver and spleen was biochemically elevated, histochemical results in this case were slightly different from those previously recorded in human and feline Niemann-Pick disease. These results suggest that this feline case might be a different type of animal Niemann-Pick disease to that reported previously.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 58 (1989), S. 195-199 
    ISSN: 1432-0584
    Keywords: Cytochemistry ; Blood ; Bone marrow ; Leukocytes ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Blood and bone marrow cells of ten clinically healthy cats were stained for alkaline phosphatase (ALP), peroxidase (PO), chloroacetate esterase (CAE), alpha-naphthyl butyrate esterase (NBE), sudanophilia, and periodic acid-Schiff (PAS) reaction. Mature neutrophils in blood and bone marrow were devoid of ALP and NBE, but exhibited modest to strong PO, CAE, sudanophilia, and PAS reaction. In bone marrow, sudanophilia, PO, and CAE were prominent at the promyelocyte stage and diminished with cellular differentiation and maturation, while PAS reactivity increased with cell maturation usually from the myelocyte stage onwards. Myeloblasts were negative for all cytochemical reactions, but some large unidentifiable cells reacted strongly for ALP. Eosinophils were slightly reactive for ALP, CAE, and PAS, but not for PO, sudanophilia, and NBE. Basophil granules stained strongly for CAE, revealed PAS positivity, and stained negatively for PO, NBE, ALP, and sudanophilia. Slight ALP activity was detected in the intergranular cytoplasm of basophils. Lymphocytes and monocytes, with few exceptions, stained negatively. An occasional lymphocyte revealed slight globular NBE activity (NaF-resistant) and diffuse PAS reaction, while an occasional monocyte contained a few PO-positive and sudanophilic granules. Monocytes reacted modestly, whereas bone marrow macrophages reacted strongly for NBE (NaF-sensitive). Cells of the erythroid series stained negatively for all cytochemical reactions, megakaryocytes were PAS-positive, and platelets gave positive reactions for PAS and CAE.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 75 (1989), S. 265-279 
    ISSN: 1432-1106
    Keywords: Rostral interstitial nucleus of the MLF ; Interstitial nucleus of Cajal ; Spinal cord ; Motoneurons ; Neck muscles ; Axial muscles ; Vertical eye and head movements ; Autoradiography ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eye and head movements are strongly interconnected, because they both play an important role in accurately determining the direction of the visual field. The rostral brainstem includes two areas which contain neurons that participate in the control of both movement and position of the head and eyes. These regions are the caudal third of Field H of Forel, including the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) and the interstitial nucleus of Cajal with adjacent reticular formation (INC-RF). Lesions in the caudal Field H of Forel in monkey and man result in vertical gaze paralysis. Head tilt to the opposite side and inability to maintain vertical eye position follow lesions in the INC-RF in cat and monkey. Projections from these areas to extraocular motoneurons has previously been observed. We reported a study of the location of neurons in Field H of Forel and INC-RF that project to spinal cord in cat. The distribution of these fiber projections to the spinal cord are described. The results indicate that: 1. Unlike the neurons projecting to the extra-ocular muscle motoneurons, the major portion of the spinally projecting neurons are not located in the riMLF or INC proper but in adjacent areas, i.e. the ventral and lateral parts of the caudal third of the Field H of Forel and in the INCRF. A few neurons were also found in the nucleus of the posterior commissure and ventrally adjoining reticular formation. 2. Neurons in caudal Field H of Forel project, via the ventral part of the ventral funiculus, to the lateral part of the upper cervical ventral horn. This area includes the laterally located motoneuronal cell groups, innervating cleidomastoid, clavotrapezius and splenius motoneurons. At lower cervical levels labeled fibers are distributed to the medial part of the ventral horn. Projections from the caudal Field H of Forel to thoracic or more caudal spinal levels are sparse. 3. Neurons in the INC-RF, together with a few neurons in the area of the nucleus of the posterior commissure, project bilaterally to the medial part of the upper cervical ventral horn, via the dorsal part of the ventral funiculus. This area includes motoneurons innervating prevertebral flexor muscles and some of the motoneurons of the biventer cervicis and complexus muscles. Further caudally, labeled fibers are distributed to the medial part of the ventral horn (laminae VIII and adjoining VII) similar to the projections of Field H of Forel. A few INC-RF projections were observed to low thoracic and lumbosacral levels. It is argued that the neurons in the caudal Field H of Forel, which project to the spinal cord are especially involved in the control of those fast vertical head movements which occur in conjunction with saccadic eye movements. In contrast the INC-RF projections to the spinal cord are responsible for slower, smaller movements controlling the position of the head in the vertical plane.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 75 (1989), S. 639-643 
    ISSN: 1432-1106
    Keywords: Motor cortex ; Somaesthetic responses ; Spinothalamic system ; Intracellular recording ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Evidence is presented that in the cat, the spinothalamic system contributes to short latency somaesthetic responses in motor cortex efferent cells. Intracellular recordings performed on identified pyramidal tract cells and corticospinal cells show that these cells are still activated and/or inhibited from the periphery after a set of central nervous lesions leaving intact only the ventral half of the spinal cord. The responses were attributed to the spinothalamic system. The ascending system is activated through collaterals of afferent fibres running in the dorsal columns of the spinal cord. This peripheral link to the motor cortex might participate in updating the motor command on the basis of information feedback from the periphery.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 76 (1989), S. 182-186 
    ISSN: 1432-1106
    Keywords: Retinal ganglion cells ; Orientation bias ; Receptive field centre ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For cat retinal ganglion cells whose receptive field centres were distributed in specified sections of the left visual field, the deviations of the major axis from the radial, horizontal, and circumferential directions were determined. The percentage of cells with deviations within ± 20° from the radial, horizontal, and circumferential directions were, respectively, 33%, 68%, 16%. In addition, comparison between values of deviation from the horizontal direction for cells located at eccentricities of 10° and 20° from the area centralis showed a statistically significant trend: the bias for the horizontal increased with eccentricity.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 76 (1989), S. 519-529 
    ISSN: 1432-1106
    Keywords: Pontine tegmentum ; Cholinergic neurons ; Single units ; Sleep-waking states ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 260 neurons were recorded in the rostral pontine tegmentum of freely moving cats during the sleep-waking cycle. Of these, 207 neurons (80%) were located in the dorsal pontine tegmentum containing monoaminergic and choline acetyltransferase (ChAT)-immunoreactive, or cholinergic neurons. In addition to presumably monoaminergic PS-off cells (n = 51) showing a cessation of discharge during paradoxical sleep (PS) and presumably cholinergic PGO-on cells (n = 40) exhibiting a burst of discharge just prior to and during ponto-geniculo-occipital (PGO) waves, we observed tonic (n = 108) and phasic (n = 61) neurons exhibiting, respectively, tonic and phasic patterns of discharge during wakefulness and/or paradoxical sleep. Of 87 tonic cells histologically localized in the dorsal pontine tegmentum rich in cholinergic neurons, 46 cells (53%) were identified as giving rise to ascending projections either to the intralaminar thalamic complex (n = 26) or to the ventrolateral posterior hypothalamus (n = 13) or to both (n = 9). Two types of tonic neurons were distinguished: 1) tonic type I neurons (n = 28), showing a tonic pattern and high rates of discharge during both waking and paradoxical sleep as compaired with slow wave sleep; and 2) tonic type II neurons (n = 20), exhibiting a tonic pattern of discharge highly specific to the periods of paradoxical sleep. Tonic type I neurons were further divided into two subclasses on the basis of discharge rates during waking: a) rapid (Type I-R; n = 17); and b) slow (Type I-S; n = 11) units with a discharge frequency of more than 12 spikes/s or less than 5 spikes/s, respectively. Like monoaminergic PS-off and cholinergic PGO-on cells, both tonic type II and type I-S cells were characterized by a long spike duration (median: 3.3 and 3.5 ms), as well as by a slow conduction velocity (median: 1.8 and 1.7 m/s). In the light of these data, we discuss the possible cholinergic nature and functional significance of these ascending tonic neurons in the generation of neocortical electroencephalographic desynchronization occurring during waking and paradoxical sleep.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 77 (1989), S. 271-282 
    ISSN: 1432-1106
    Keywords: Red nucleus ; Motor initiation ; Single-unit activity ; Reaction time ; Delayed movement ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activity of 98 Red Nucleus neurons was recorded in 3 cats operantly conditioned to perform a ballistic forelimb flexion movement triggered after a brief sound in a simple Reaction Time condition, or Delayed after the same sound in the presence of a tone cue. Fifty-eight task related neurons presented changes of activity in either one or both conditions. Forty-four of them were studied quantitatively and classified in 3 categories: 1) only 16% of the units presented similar changes of firing preceding the triggered or delayed movement; 2) most units (55%) presented different changes of activity in the two conditions: in the Delayed condition, the activation occurred earlier before the movement, and/or the change in magnitude was reduced or the pattern of activity was modified; 3) moreover, for 29% of the units, the change of activity observed before movement in the Reaction Time condition was severely reduced or even absent in the Delayed condition. For some of these neurons a building-up of activity was observed very early in the Reaction Time condition, during the preparatory period, well before the occurrence of the conditioned stimulus. These results show that the Red Nucleus activity preceding a movement is clearly dependent on its initiation conditions. The distinct patterns of unit firing observed in the Reaction Time condition and in the Delayed condition are tentatively related to the different preparation and initiation constraints determined by the behavioral conditions.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 77 (1989), S. 577-584 
    ISSN: 1432-1106
    Keywords: Motoneuron pool ; Inhibition ; Monosynaptic reflex ; Recruitment level ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The motoneurons to the Soleus muscle in the decerebrate cat were activated by the crossed extensor reflex, elicited by stimulation of the contralateral common peroneal (CP) nerve. Monosynaptic reflexes were obtained from the Soleus motoneuron pool by stimulation of the cut L7-S1 dorsal roots. The amplitude of the reflex increased approximately linearly with the recruitment level of the motoneuron pool. Tonic postsynaptic inhibition was induced in the Soleus moto-neuron pool by repetitive antidromic stimulation of the Lateral Gastrocnemius (LG) and Medial Gastrocnemius (MG) nerves at a rate of 17–47 stimuli/s. This reduced the size of the monosynaptic reflex at rest by at least 40%. However, when the motoneurons were active, the amplitude of the monosynaptic reflex obtained during repetitive stimulation of the LG-MG nerve increased with the recruitment level along the same curve as the control reflexes. Thus, tonic postsynaptic inhibition of the motoneurons per se cannot control the amplitude of the monosynaptic reflex independently of the recruitment level of the motoneuron pool. These experimental results verify predictions from computer simulations and suggest by exclusion that presynaptic inhibition is needed to control the amplitude of the monosynaptic reflex independently of the recruitment level of the motor pool.
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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 74 (1989), S. 220-226 
    ISSN: 1432-1106
    Keywords: Cat ; Medial geniculate body ; Hearing ; Tonotopic organization ; Single unit recording
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The tonotopic organization observed in the present study for the pars lateralis (LV) of the medial geniculate body (MGB) in nitrous oxide anesthetized cats is generally consistent with that previously reported under barbiturate anesthesia. The present data, however, provide evidence for local deviations in characteristic frequency (CF) using appropriate sampling procedures of single units. Although the majority of pairs of units recorded simultaneously with the same microelectrode showed comparable CFs, a few pairs of such neighbouring units displayed CF disparities of up to 1.5 octaves. In addition, some units characterized by an elevated threshold had a CF deviating significantly from the general CF progression observed for the majority of units having low thresholds. This study points out the influence of the sampling procedure on the quality of the tonotopic organization observed in the MGB in addition to a possible effect of the level of anesthesia.
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 76 (1989), S. 307-314 
    ISSN: 1432-1106
    Keywords: Moving stimuli ; Orientation specificity ; Preferred axes ; Spot-response-axis ; Striate cortex ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The responses of 82 simple cells and 41 complex cells in area 17 of anesthetized and paralysed cats were examined with light bars of different length. For 84% of the simple cells and 66% of the complex cells the preferred axis of orientation of a stationary flashing long bar (orientational selectivity) and the preferred axis of movement of a small spot were parallel. As a consequence, the axis of maximal response to a moving light spot was mostly orthogonal to the optimal axis of a moving bar. Thus, a single cell responds to two perpendicular axes of preferred movement one for a long bar and one for a light spot, respectively. For both axes independent direction preferences could be distinguished. Additional preferred axes of movement between the two orthogonal extremes could be found with moving bars of intermediate lengths. This can be explained by the fact that cells with a pronounced response to a moving spot showed a strong tendency for intermediate bar length to elicit responses consisting of a superposition of both components. Therefore, decreasing bar length resulted in a gradual rotation of the preferred direction of movement from orthogonal to parallel with respect to the orientational axis, rather than to a mere widening of the tuning curve. Accordingly, the change in orientation selectivity with decreasing bar length is a regular transition from the orientation dependent response to a response type that depends only on the movement axis of the spot. Thus, in a simple model, the resulting response characteristic can be interpreted as an average of both components weighted according to the length of the stimulus.
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 77 (1989), S. 94-102 
    ISSN: 1432-1106
    Keywords: Eye movement ; Brainstem ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study maps the eye movements evoked by microstimulations in the medulla of 9 alert cats. Trains of square waves (20 μA amplitude, 0.2 msec duration, 200 Hz) were delivered through glass-covered tungsten microelectrodes (0.5–1 MΩ). Movements of both eyes were recorded by the magnetic field/eye coil technique. Stimulation of the prepositus hypoglossi nucleus (PH) evoked nystagmus with ipsilaterally-directed slow phases followed by after-nystagmus with contralaterally-directed slow phases. Stimulation of the medial vestibular nucleus (MVN) induced nystagmus whose slow phases were more often ipsilaterally-directed but at time contralaterally-directed. At nearly all sites where we stimulated the reticular formation underlying prepositus and vestibular nuclei (from P4.5 to P12), we recorded versional conjugate movements. They were most often ipsilaterally-directed. Some microstimulations in the region of the medial longitudinal fasciculus evoked recentering eye movements: regardless of the initial position of the gaze (to the left as well as to the right), microstimulations given at the same place induced a movement of both eyes toward their neutral position. The amplitude of this movement was proportional to the eccentricity of the pre-stimulation position of the gaze.
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  • 14
    ISSN: 1432-1106
    Keywords: Pharyngeal vagus nerve ; Pharyngeal glossopharyngeal nerve ; Nucleus ambiguus ; Retrofacial nucleus ; Lateral reticular formation ; Nucleus of solitary tract ; Alaminar spinal trigeminal nucleus ; Horseradish peroxidase ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The central distributions of efferent and afferent components of the pharyngeal branches of the vagus (PH-X) and glossopharyngeal (PH-IX) nerves in the cat were studied by soaking their central cut ends in a horseradish peroxidase (HRP) solution. HRP-labelled PH-X neurones were distributed ipsilaterally in the rostral part of the nucleus ambiguus (NA) and the retrofacial nucleus (RFN); HRP-labelled PH-IX neurones were found in the ipsilateral RFN and the bulbopontine lateral reticular formation (RF). Vagal pharyngeal neurones constituted a large population of brainstem motoneurones. The population of HRP-labelled glossopharyngeal neurones was divided into two components. Indeed, on the basis of their location and somal morphology, the most ventral cells were identified as cranial motoneurones and those scattered in the lateral RF as parasympathetic preganglionic neurones. Application of HRP to the PH-IX nerve resulted also in the labelling of fibres and terminals in the alaminar spinal trigeminal nucleus and the nucleus of the solitary tract (NTS). The afferent fibres entered the lateral medulla with the glossopharyngeal roots, ran dorsomedially, then turned caudally toward the NTS and the caudal part of the alaminar spinal trigeminal motor (V) nucleus. In the NTS, labelled fibres ran mainly along the solitary tract, projecting to terminals in the dorsal and dorsolateral nuclei of the NTS.
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  • 15
    ISSN: 1432-1106
    Keywords: Lateral geniculate nucleus ; Optic tract ; Sustained cells ; Transient cells ; Temporal luminance modulation ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We recorded the response of sustained (X) and transient (Y) cells in the cat lateral geniculate nucleus (LGN) and optic tract to a stationary spot while the spot luminance was increased and decreased with a constant rate (linear luminance functions), or modulated sinusoidally. The spot filled the receptive field center, and was surrounded by an annulus of fixed luminance. The LGN X cells seemed to perform a differentiation-like operation in the time domain at slow temporal modulations, giving information about rate of luminance change. To the linear luminance functions the cells responded with a constant firing rate. The on-center cells were activated during increasing luminance, the off-center cells during decreasing luminance. This firing rate increased monotonically with rate of luminance change. To low-frequency sinusoidal modulations the cells had a marked negative phase shift. The response of the LGN Y cells had a transient component shortly after the luminance started to increase (on-center cells) or decrease (off-center cells), followed by a secondary, gradually changing component. The peak of the transient component occurred on average when the response of the X cells increased most rapidly. To low-frequency sinusoidal modulation the average negative phase shift of this peak was twice the average of the X cells. The Y system could accordingly provide information about rate of change in the response of the X system. In the optic tract the X fiber response resembled the LGN X cell response in most respects. The Y fibers had only a weak transient response component, so this component was accentuated in the thalamic relay. Also the sensitivity for rate of luminance change was increased in LGN.
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 74 (1989), S. 131-138 
    ISSN: 1432-1106
    Keywords: Phrenic motoneurons ; Intracellular recording ; Interactions ; Recurrent EPSPs ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Intracellular recordings were made from 220 Phrenic Motoneurons (PM) in anaesthetized, spontaneously breathing cats, deafferented from C3 to C7, in order to look for somatic events related to the Recurrent Responses (RR) evoked in PM axons by repetitive stimulation of the phrenic nerve. RR appear sporadically at a constant latency, originate from a spinal nicotinic mechanism and can be evoked in a PM without the presence of an antidromic volley in its axon (Khatib et al. 1986). 2. Using stimuli effective for eliciting RR in axons, we failed to observe intracellularly somatic events corresponding to RR after the occurence of an antidromic action potential. RR were observed extracellularly in two cases, but in both cases the recording originated from axons. 3. We attempted to elicit somatic RR without a preceding antidromic action potential, using either parathreshold stimulation of the impaled PM, or suprathreshold stimulation of a phrenic strand which excluded the axon of the impaled PM. In both cases, RR-like events, with very stable latencies, appeared sporadically in 4/142 and 2/15 PMs respectively. 4. Parathreshold stimuli or stimulation of a strand were coupled with averaging of the synaptic noise in order to look for small events temporally related to the stimuli. Short latency small depolarizations, looking-like recurrent EPSPs, were revealed in 22/142 and 5/15 PMs respectively. 5. These results confirm the existence of interrelations between PMs, providing for re-excitation and coupling within the phrenic pool, in addition to centrally imposed synchronization.
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  • 17
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    Electronic Resource
    Springer
    Experimental brain research 74 (1989), S. 272-278 
    ISSN: 1432-1106
    Keywords: Cat ; Corpus callosum ; Optic chiasm ; Stereoacuity ; Visual acuity ; Visual fields
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the role of the transcallosal pathway in stereopsis by measuring binocular and monocular depth perception in two cats that had undergone section of the optic chiasm at the age of 21 d. To ensure that the surgery did not impair vision to the extent that depth perception could not be evaluated, visual acuity and visual fields were also measured. In both of the chiasm-sectioned animals the visual fields were reduced and the visual acuity was substantially lower than in normal cats, with a maximum of about 2 cyc deg-1. Binocular depth thresholds of the chiasm-sectioned cats were worse than those of the normal cat but were better than their own monocular thresholds. These results suggest that the chiasm-sectioned animals were still able to use binocular cues to judge depth and indicate that the indirect pathway through the corpus callosum is sufficient to mediate binocular depth perception.
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  • 18
    ISSN: 1432-1106
    Keywords: Precerebellar nuclei ; Cerebellar cortex and nuclei ; Fluoro-Gold ; Rhodamine-B-isothiocyanate (RITC) ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The projections from certain brain stem precerebellar nuclei to the cerebellar cortex and nuclei have been examined in the cat by using the retrograde fluorescent double-labelling technique. Crystalline Fluoro-Gold was implanted into the left cerebellar nuclei from the contralateral side and rhodamine-B-isothiocyanate was injected into the overlying cerebellar cortex. The inferior olive, the lateral reticular nucleus, and the reticular tegmental pontine nucleus all contained double- as well as single-labelled neurons, and it was concluded that these nuclei have a high number of neurons whose axons branch to both the cerebellar cortex and nuclei. The neurons in the paramedian reticular nucleus and the pontine nuclei proper appear to project only to the cerebellar cortex.
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  • 19
    ISSN: 1432-1106
    Keywords: Cutaneous EPSPs ; Fictive locomotion ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined modulation of transmission in short-latency, distal hindlimb cutaneous reflex pathways during fictive locomotion in 19 decerebrate cats. Fictive stepping was produced either by electrical stimulation of the mesencephalic locomotor region (MLR) or by administration of Nialamide and 1-DOPA to acutely spinalized animals. Postsynaptic potentials (PSPs) produced by electrical stimulation of low threshold afferents (〈 2.5 times threshold) in the superficial peroneal (SP), sural, saphenous or medial plantar nerves were recorded intracellularly from various extensor (n = 28) and flexor (n = 24) motoneurons and averaged throughout the step cycle, together with voltage responses to intrasomatic constant current pulses (in order to monitor relative cell input resistance). Each motoneuron studied displayed rhythmic background oscillations in membrane potential and correlated variations in input resistance. The average input resistance of extensor motoneurons was lowest during mid-flexion, when the cells were relatively hyperpolarized and silent. Conversely, average input resistance of flexor motoneurons was highest during mid-flexion, when they were depolarized and active. The amplitude of the minimum-latency excitatory components of PSPs produced by cutaneous nerve stimulation were measured from computer averaged records representing six subdivisions of the fictive step cycle. Oligosynaptic EPSP components were consistently modulated only in the superficial peroneal responses in flexor motoneurons, which exhibited enhanced amplitude during the flexion phase. With the other skin nerves tested (sural, saphenous, and plantar), no consistent patterns of modulation were observed during fictive locomotion. We conclude that transmission through some, but not all, oligosynaptic excitatory cutaneous pathways is enhanced by premotoneuronal mechanisms during the flexion phase of fictive stepping in several cat hindlimb motor nuclei. The present results suggest that the patterns of interaction between the locomotor central pattern generator and excitatory cutaneous reflex pathways depend on the source of afferent input and on the identity of the target motoneuron population.
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  • 20
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    Experimental brain research 78 (1989), S. 336-344 
    ISSN: 1432-1106
    Keywords: Vagal pharyngeal nerve ; Glossopharyngeal nerve ; Single fibre recordings ; Respiratory-related units ; Superior laryngeal nerve ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In decerebrate, paralyzed and artificially ventilated cats, we recorded the discharge of 64 motor axons supplying the pharyngeal muscles. Filaments containing motor axons, with discharges related to the respiratory cycle (phrenic nerve activity), were teased from the pharyngeal branches of the vagus and glossopharyngeal nerves. Most units (n = 41) fired only during expiration and exhibited a steady, a decreasing or a late augmenting discharge pattern. These units were found only in vagal filaments. Twenty three units discharged during inspiration and exhibited a steady, a late augmenting or a tonic discharge pattern. The inspiratory-related units were present in both the vagus (n=13) and glossopharyngeal (n=10) nerves. Nineteen of 20 pharyngeal inspiratoryrelated units tested were activated at short latency (range 3.4 to 8.0 ms) by stimulation of afferents in the superior laryngeal nerve (SLN). In 13 of these, such stimulation also suppressed their spontaneous activity. SLN stimulation elicited in all 17 pharyngeal expiratory-related units tested a short latency (range 0 to 8 ms) reduction of activity, followed in 7 units by an increase in activity. SLN stimulation occasionally evoked single or rhythmic multifibre bursts in the vagal pharyngeal filaments. These bursts, involving expiratory-related units, likely correspond to the buccopharyngeal stage of swallowing.
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  • 21
    ISSN: 1432-1106
    Keywords: Bicuculline ; Inhibition ; Latency ; Receptive field profile ; Somatosensory cortex ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In cortical area 3b of cats, responses of 76 single neurons to punctate indentations were recorded before and during iontophoretic administration of bicuculline methiodide (BMI), a GABAergic antagonist, at levels that did not affect spontaneous activity. Constant amplitude indentations were applied to selected sites along distalproximal and radial-ulnar axes that intersected the most sensitive area in the receptive field. Profiles of response magnitudes were used to measure receptive field dimensions before and during antagonism of GABAergic inhibition. Blockade of GABAergic transmission caused receptive field dimensions of 48 rapidly-adapting neurons to increase an average 141%, or nearly 2.5 times their original size. Analysis of the spatial distribution of inhibition indicated that in-field inhibition was larger than surround inhibition. During BMI administration, response latency was significantly longer for response elicited from the expanded territory than for responses elicited from within the original receptive field, suggesting that receptive field expansion might be mediated by multisynaptic intracortical connections. The magnitude of receptive field expansion was independent of receptive field size or peripheral location. In a substantial number of neurons, however, BMI produced asymmetric expansions that extended only in the proximal direction. For 9 slowly-adapting neurons, BMI produced measureable increases in receptive field dimensions, but these changes were significantly smaller than the changes in rapidly-adapting neurons.
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  • 22
    ISSN: 1432-1106
    Keywords: NMDA receptor ; Visual cortex ; Excitatory amino acid ; Slice ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Actions of excitatory amino acid (EAA) antagonists on the responses of cells in layers II/III and IV of the cat's visual cortex to stimulation of layer VI and the underlying white matter were studied in slice preparations. Antagonists used were 2-amino-5-phosphonovalerate (APV), a selective antagonist for the N-methyl-D-aspartate (NMDA) type of EAA receptors, and kynurenate, a broadspectrum antagonist for the three types of EAA receptors. In extracellular recordings it was demonstrated that most of the layer II/III cells were sensitive to APV, while the great majority of the layer IV cells were not, By contrast, kynurenate suppressed the responses completely in both layers. Excitatory post-synaptic potentials (EPSPs) evoked by stimulation of layer VI and the while matter were recorded intracellularly from layer II/III neurons. To determine whether the EPSPs were elicited mono- or polysynaptically, the synaptic delay for each EPSP was calculated from a pair of onset latencies of EPSPs evoked by stimulation of the two sites. Forty-two percent of the layer II/III cells were classified as having monosynaptic EPSPs. In 60% of these monosynaptic cells, the rising slope of the EPSPs was reduced by APV while in the other 40%, it was not. In the former (APV-sensitive cells), subtraction of the APV-sensitive component from the total EPSP indicated that the onset latency of the NMDA receptor-mediated component was roughly equal to that of the non-NMDA component. In the latter (APV-resistant cells), only the slowly-decaying component was in part mediated by NMDA receptors. The conduction velocities of the afferent fibers innervating APV-resistant cells were slower than those of the APV-sensitive cells, suggesting that both types of cells are innervated by different types of afferents. The polysynaptic EPSPs of almost all layer II/III cells were sensitive to APV. The subtraction method indicated that the NMDA component had about the same magnitude as the non-NMDA components. When the slices were superfused by a Mg2+-free solution, the EPSPs were potentiated dramatically, but this potentiation was reduced to the control level during the administration of APV. Similarly, APV-sensitive components were potentiated during the administration of bicuculline, a selective antagonist for gamma-aminobutyric acid receptors of A type. These results suggest that NMDA receptors participate, at varying degrees, in excitatory synaptic transmission at most layer II/III cells in the cat's visual cortex, and their actions appear to be regulated by intracortical inhibition.
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  • 23
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    Experimental brain research 78 (1989), S. 374-379 
    ISSN: 1432-1106
    Keywords: Thermosensitivity ; Spinal cord ; Ascending pathways ; Behaviour ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The behavioural thermosensitivity of six cats was measured before and after single stage, symmetrical, bilateral, surgical lesions of the cervical spinal cord. The lesions were aimed at an area in the most ventral parts of the dorsal halves of the lateral funiculi. Unilateral lesions of that area have previously been found to cause reproducible, although subtotal, contralateral thermosensory defects, which were attributed to interruption of the thermosensory spinothalamic pathway. The lesions of three of the present cats were found to be incomplete, and those animals showed no postoperative thermosensory deficiency. Two of the cats with complete lesions showed marked post-operative defects, especially immediately after the operations, but the third cat with a complete lesion showed no postoperative thermosensory defect at all. The differences between the last three animals have been compared to the irregularity of previous reports about thermosensitivity after spinal cord lesions in man and animals, and may depend on the testing technique, rather than differences of thermosensitivity per se.
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  • 24
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    Experimental brain research 78 (1989), S. 501-513 
    ISSN: 1432-1106
    Keywords: Somatosensory cortex ; Interlaminar ; Corticortical ; SI ; Area 3b ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The morphology of single neurons in area 3b of cat primary somatosensory (SI) cortex was examined after horseradish peroxidase (HRP) injections. Neurons were labeled either by intracellular injection of HRP following intracellular recording or by small extracellular iontophoretic HRP injections. Both pyramidal and nonpyramidal neurons were labeled and reconstructed from serial sections. Their axons had local, interlaminar and interareal patterns of termination. Most neurons formed local axonal fields around their cell bodies and dendrites. Pyramidal neurons in cortical layer IV sent axons up into layers II and III, neurons in layers II and III sent axons down to layer V, and layer V neurons sent axons to layer VI as well as back to the upper layers. Layer VI neurons sent axons back to the upper cortical layers in a unique bowl-shaped pattern. The horizontal distribution of axons of pyramidal cells in layer III was extremely widespread. Axons of layer III neurons in area 3b terminated within 3b and area 1, but not in other areas of SI. Layer III neurons in area 1 distributed axon collaterals to all fields of SI as well as projecting a main axon to motor cortex. In general, the axon collaterals of area 3b pyramidal cells outside layer III remained confined to area 3b. Most of the nonpyramidal neurons labeled were basket cells in layers III and VI. These neurons formed dense axonal fields around their cell bodies, and none of their axons could be followed into the underlying white matter. The results of the present study demonstrate that area 3b somatosensory cortical neurons and their axons are vertically organized in a manner similar to that reported for other sensory cortical areas. They also show that widespread horizontal connections are formed by pyramidal neurons of layer III, and that these horizontal axons can travel for great distances in the cortical grey matter.
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  • 25
    ISSN: 1432-1106
    Keywords: Motor cortex ; Conditioned movement ; Posture ; Balance control ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of the sensorimotor cortex in the postural adjustments associated with conditioned paw lifting movements was investigated in the cat. Cats were trained to stand quietly on four strain gauge equipped platforms and to perform a lift-off movement with one forelimb when a conditioned tone was presented. The parameters recorded were the vertical forces exerted by the paws on each platform, the lateral and antero-posterior displacements of rods implanted on the T2, T12, L5 vertebrae as well as their rotation, and the EMG of triceps and biceps of both forelimbs. Before lesion, the postural adjustment consisted of a “nondiagonal” pattern where the CG was displaced laterally inside the triangle formed by the three remaining supporting limbs. Here a lateral bending of the thoracic column toward the supporting forelimb could be observed. The associated EMG pattern consisted of an early activation of the triceps lateral head in the moving limb which was probably responsible for the body displacement toward the opposite side, and a late biceps activation associated with the lift. In the supporting forelimb, a coactivation of the biceps and triceps was usually present. After contralateral sensorimotor lesion, the conditioned lifting movements were lost for 4–15 days after the lesion, before being subsequently recovered. The same lateral CG displacement and bending of the back was seen after lesion as before, which indicates that the goal of postural adjustment was preserved. However, the means of reaching it were modified. In most of the intact animals, the CG displacement was achieved in one step, whereas in the animals with lesions, the displacement was made either according to a slow ramp mode or in a discontinuous manner involving several steps. The mechanisms responsible for this disturbance are discussed.
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  • 26
    ISSN: 1432-1106
    Keywords: Somatosensory cortex ; Directional sensitivity ; GABA inhibition ; Picrotoxin ; Bicuculline ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of intracortical inhibitory processes in the formation of neuronal receptive fields in the vibrissal projection zone of the somatosensory cortex was studied. Iontophoretic application of picrotoxin and bicuculline blocks the inhibition and causes the loss of directional sensitivity in neurons. Activation of inhibition by distant glutamate application gives opposite results — neurons become direction sensitive. A dependence was found between spatial location of activated cells and the pattern of changes of their detector properties. Inhibitory processes caused by natural afferent stimulation lead to similar changes in the functional properties of neurons.
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  • 27
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    Experimental brain research 78 (1989), S. 203-213 
    ISSN: 1432-1106
    Keywords: Corpus callosum ; Development ; Vision ; Dark rearing ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is now well established that during normal postnatal development there is a partial elimination of the callosal projections of cortical areas 17 and 18 in the cat and that visual experience early in life can modulate this process. In the present experiments, we quantitatively studied the influence of light, per se, by rearing cats in total darkness. Dark rearing exaggerates the normally occurring partial elimination of immature callosal projections: it causes a significant reduction in the total number of neurons in both the supra-and infragranular layers that send an axon through the corpus callosum and slightly narrows the distribution of these neurons across areas 17 and 18. These data demonstrate that visual stimulation is not necessary either to initiate the partial elimination of immature callosal projections or to stabilize a large fraction of the callosal projections present at birth. However, normal visual stimulation is necessary for the stabilization of the normal complement of callosal projections.
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  • 28
    ISSN: 1432-1106
    Keywords: Control of respiration ; Intercostal muscle afferents ; Phrenic nerve ; Abdominal muscle afferents ; Expiratory neurons ; Abdominal muscle control ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Our objective was to determine if caudal ventral respiratory group (VRG) expiratory (E) neurons that drive abdominal expiratory motoneurons in the lumbar cord respond to intercostal and lumbar nerve afferent stimulation. Results showed that 92% of medullary E-neurons that were antidromically activated from the upper lumbar cord reduced their activity in response to stimulation of external and internal intercostal and lumbar nerve afferents. We conclude that afferent information from intercostal and abdominal muscle tendon organs has an inhibitory effect on caudal VRG E-neurons that drive abdominal expiratory motoneurons.
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  • 29
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    Pflügers Archiv 414 (1989), S. 235-244 
    ISSN: 1432-2013
    Keywords: Cat ; Urinary bladder ; Parasympathetic ganglion neurone ; Postganglionic stimulation ; Synaptic potentials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intracellular recording techniques were used to examine and compare synaptic potentials evoked by stimulating pre- and postganglionic nerve trunks in cat bladder parasympathetic ganglia. In the 76 ganglion cells exammed, two types of responses were recorded on stimulating the postganglionic nerve: an antidromic action potential (type Post NS1;n=30) or a fast excitatory postsynaptic potential (f-EPSP; type PostNS2;n=46) which resulted in an orthodromic-like action potential. In some of the cells exhibiting a PostNS1 response (n=19), a fast depolarization was superimposed on the antidromic spike. This depolarization was due to the synaptic activation of nicotinic receptors. In many of the cells exhibiting either PostNS1 or PostNS2 responses, repetitive stimulation of the postganglionic nerve induced a slow hyperpolarization. Applying nicotinic (hexamethonium, methonium, 0.5–1 mM), muscarinic (atropine, 1 μM), alpha-adrenergic (phentolamine, 1 μM) and purinergic (caffeine, 0.5–1 mM) receptor antagonists completely inhibited the tetanus-induced slow hyperpolarization in some cells (n=5). In other cells (n=15), a slow hyperpolarization persisted in the presence of these antagonists. These results indicate that stimulation of the postganglionic nerve trunk of cat bladder parasympathetic ganglia can elicit not only an antidromic action potential, but also synaptic potentials which are mediated by the activation of cholinergic (nicotinic and muscarinic), noradrenergic and purinergic receptors, as well as a non-cholinergic, non-alpha-adrenergic and non-purinergic synaptic potential.
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  • 30
    ISSN: 1432-2072
    Keywords: Oro-facial dyskinesia ; Globus pallidus ; GABA ; Acetylcholine ; Behaviour ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The possible role of cholinergic mechanisms in the sub-commissural part of the globus pallidus (scGP) in the induction of oro-facial dyskinesia (OFD) was studied in cats. Local injections of the cholinergic agonist carbachol into the scGP elicited tongue protrusions in a dose dependent way (100–1000 ng/0.5 μl). The effect elicited by 1000 ng carbachol was selectively antagonized by the cholinergic antagonist scopolamine (10 μg/0.5 μl); this dose of scopolamine was ineffective when injected alone. The tongue protrusions resulted from both normal and abnormal movements: whereas normal movements simply consisted of protruding the flat tongue, abnormal movements implied a variety of movements, especially curling upwards the lateral side(s) or tip of the tongue inside or outside the oral cavity. The abnormal carbachol-induced tongue protrusions formed part of a syndrome marked by dyskinetic movements of the muscles of the eye, ear and cheek, and were identical to those seen previously after local injections of picrotoxin (250–500 ng). Intra-pallidal injections of the abovementioned dose of scopolamine had no effect on the tongue protrusions induced by local injections of 375 ng picrotoxin. However, local injections of 100 ng muscimol, which was previously found to attenuate significantly the effect of 375 ng picrotoxin and which was ineffective when injected alone, significantly attenuated the tongue protrusions induced by local injections of 1000 ng carbachol. These data suggest that the cholinergic effects are mediated via a GABAergic mechanism, but not vice versa. The results are discussed in view of GABAergic and anticholinergic therapies used in oro-facial dyskinesia.
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  • 31
    ISSN: 1432-1912
    Keywords: 5-HT3 receptors ; Radioligand binding ; [3H]ICS 205-930 ; Cat ; Rabbit ; Vagus nerve ; Superior cervical ganglion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The binding characteristics of [3H]ICS 205-930, a 5-hydroxytryptamine 5-HT3 receptor antagonist, were investigated in membranes prepared from cat and rabbit vagus nerve (VN) and superior cervical ganglion (SCG). The autoradiographic localisation of 5-HT3 recognition sites was also assessed using [3H]ICS 205-930 in slices from cat medulla oblongata, nodose ganglion and vagus nerve. [3H]ICS 205-930 bound to a homogeneous population of high affinity recognition sites in cat VN: Bmax = 201 ± 43 fmol/mg protein, pKD = 9.26 ± 0.17 and SCG: Bmax = 291 ± 40 fmol/mg, pKD = 9.35 ± 0.80 (n = 3). Competition experiments performed in membranes from cat VN and SCG with agonists and antagonists suggested the presence of a homogeneous population of [3H]ICS 205-930 recognition sites. Competition curves were steep and monophasic and were best fitted by a 1 receptor site model. The following rank order of affinity for [3H]ICS 205-930 binding sites was observed with antagonists: SDZ 206-830 = ICS 205-930 〉 BRL 43694 〉 SDZ 206–792 〉 quipazine 〉 MDL 72222 〉 metoclopramide 〉 mCPP and agonists: 2-methyl-5-HT = 5-HT 〉 phenylbiguanide. A similar profile was observed for a limited series of compounds in rabbit membranes. Drugs acting at 5-HT1, 5-HT2 and dopamine receptors (domperidone, spiperone and metergoline) showed very low affinities for [3H]ICS 205-930 recognition sites. The sites labelled with [3H]ICS 205-930 in vagus nerve and superior cervical ganglion of both species displayed the pharmacological profile of a 5-HT3 receptor. There was a significant correlation between the rank order of affinity of the tested compounds for [3H]ICS 205-930 recognition sites in cat and rabbit membranes and their rank order of affinity for 5-HT3 receptors from neuroblastoma-glioma NG 108-15 cells. Autoradiographic studies suggest that [3H]ICS 205-930 binding sites are present over and around the nodose ganglion cell somata, along certain fibers of the vagus nerve and in the terminal areas of this nerve in the medullar nucleus of the vagus. The present data demonstrate that [3H]ICS 205-930 identifies 5-HT3 receptors in preparations of cat and rabbit vagus nerve and superior cervical ganglion.
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  • 32
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    Naunyn-Schmiedeberg's archives of pharmacology 340 (1989), S. 764-766 
    ISSN: 1432-1912
    Keywords: Nucleus of the solitary tract (NTS) ; GABA release ; Carotid occlusion ; Blood pressure ; Push-pull cannula ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In anaesthetized cats, the nucleus of the solitary tract was bilaterally superfused through push-pull cannulae with artificial cerebrospinal fluid (CSF) and the effect of carotid occlusion on the release of endogenous GABA was investigated. Bilateral carotid occlusion led to a rise in blood pressure which was associated with a very pronounced increase in the release rate of GABA in the nucleus of the solitary tract. The results demonstrate the hypertensive function of GABA in the nucleus of the solitary tract and the importance of GABAergic neurons of this nucleus for the central cardiovascular control.
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  • 33
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    Cell & tissue research 258 (1989), S. 611-616 
    ISSN: 1432-0878
    Keywords: Cell communication ; Dye-coupling ; Odontoblasts ; Gap junctions ; Dentin sensitivity ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cell communication between odontoblasts was investigated with the use of fluorescent-dye tracers; Lucifer Yellow CH (molecular weight = 457.3), and dextran-Lucifer Yellow CH (average molecular weight = 10000). Dyes were injected into cell bodies of individual odontoblasts via an intracellular microelectrode or into a group of cells through their processes, and passage to adjacent cells was examined with a fluorescence microscope. Lucifer Yellow CH appeared to diffuse very easily among odontoblasts, while dextran-Lucifer Yellow remained within the injected cell or cells. This efficient migration of Lucifer Yellow CH can be considered a functional manifestation of gap junctions between odontoblasts.
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  • 34
    ISSN: 1432-0878
    Keywords: Autonomic ganglia ; Spinal ganglia ; Sensory neurons ; Neurotransmitters ; Sweat glands ; Blood vessels ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The neuronal subpopulations in the cat stellate, lower lumbar and sacral sympathetic ganglia were studied with regard to the cellular distribution of immunoreactivity to tyrosine hydroxylase (TH), acetylcholinesterase (AChE) and various neuronal peptides. Coexistence of neuropeptide Y (NPY)- and galanin (GAL)-like immunoreactivity (LI) was found in a high proportion of the neuronal cell bodies; these cells also contained immunoreactivity to TH, confirming their presumably noradrenergic nature. Some TH- and GAL-immunoreactive principal ganglion cells lacked NPY-LI. Two populations (scattered and clustered) of vasoactive intestinal polypeptide (VIP)- and peptide histidine isoleucine (PHI)-positive cell bodies were found in the sympathetic ganglia studied. The scattered VIP/PHI neurons also contained AChE-LI, calcitonin gene-related peptide (CGRP)-and, following culture, substance P (SP)-LI. The clustered type only contained AChE-LI. In the submandibular and sphenopalatine ganglia, neurons were AChE- and VIP/ PHI-immunoreactive but lacked CGRP- and SP-LI. Many GAL- and occasional TH-positive neurons were found in these ganglia. In the spinal ganglia, single NPY-immunoreactive sensory neuronal cells were observed, in addition to CGRP- and SP-positive neurons. The present results show that there are at least two populations of sympathetic cholinergic neurons in the cat. Retrograde tracing experiments indicate that the scattered type of cholinergic neurons contains four vasodilator peptides (VIP, PHI, CGRP, SP) and provides an important input to sweat glands, whereas the clustered type (containing VIP and PHI) mainly innervates blood vessels in muscles.
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  • 35
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    Cell & tissue research 257 (1989), S. 549-554 
    ISSN: 1432-0878
    Keywords: Salivary secretion ; Parotid gland ; Exocytosis ; Secretory granules ; Autonomic nerve-stimulation ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Electron microscopy of cat parotid glands revealed great heterogeneity in the secretory granules of normal unstimulated acinar cells. Electrical stimulation of the parasympathetic nerve to the gland evoked a copious flow of parotid saliva which was accompanied by an extensive depletion of the secretory granules from the acinar cells. Exocytosis was captured as it was occurring by means of perfusion-fixation, and showed that the events occur in a conventional manner. Stimulation of the sympathetic nerve caused only a very small flow of saliva, and no acinar degranulation was detected. It can be concluded that the parasympathetic secretomotor axons provide the main drive for parotid acinar degranulation in the cat. This contrasts with the rat in which sympathetic impulses provide the main stimulus for parotid acinar degranulation. These dissimilarities serve to emphasise how extensively species differences may influence autonomic responses in salivary glands.
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  • 36
    ISSN: 1573-9686
    Keywords: Electrical stimulation ; Neural damage ; Peripheral nerve electrode ; Peroneal nerve ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Helical electrodes were implanted around the left and right common peroneal nerves of cats. Three weeks after implantation one nerve was stimulated for 4–16 hours using charge-balanced, biphasic, constant current pulses. Compound action potentials (CAP) evoked by the stimulus were recorded from over the cauda equina before, during and after the stimulation. Light and electron microscopy evaluations were conducted at various times following the stimulation. The mere presence of the electrode invariably resulted in thickened epineurium and in some cases increased peripheral endoneurial connective tissue beneath the electrodes. Physiologic changes during stimulation included elevation of the electrical threshold of the large axons in the nerve. This was reversed within one week after stimulation at a frequency of 20 Hz, but often was not reversed following stimulation at 50–100 Hz. Continuous stimulation at 50 Hz for 8–16 hours at 400 μA or more resulted in neural damage characterized by endoneurial edema beginning within 48 hours after stimulation, and early axonal degeneration (EAD) of the large myelinated fibers, beginning by 1 week after stimulation. Neural damage due to electrical stimulation was decreased or abolished by reduction of the duration of stimulation, by stimulating at 20 Hz (vs. 50 Hz) or by use of an intermittent duty cycle. These results demonstrate that axons in peripheral nerves can be irreversely damaged by 8–16 hours of continuous stimulation at 50 Hz. However, the extent to which these axons may subsequently regenerate is uncertain. Therefore, protocols for functional electrical stimulation in human patients probably should be evaluated individually in animal studies.
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  • 37
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 27 (1989), S. 169-183 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The dynamic behaviour of marine vehicles in extreme sea states is a matter of great concern following some recent and dramatic mishaps. The complex problem of its prediction can be approached from the study, yet of broader scope, of non-linear dynamic systems subjected to stochastic excitations. However, a general non-linear stochastic dynamic theory is not yet available.A new technique, the so-called linearize-and-match method, for predicting the response statistics of non-linear systems, is presented. Essentially, the technique involves the construction of an infinite series of linear systems aimed at the prediction of the response statistical moments of a given order.The linear systems are successively defined by linearizing the original, non-linear system and matching the Volterra functional model response statistics to the desired order. The linear system for predicting second order statistics is shown to coincide with the one obtained using the method of equivalent linearization.Response probability distributions can be constructed from the knowledge of such statistics. Particular attention is devoted to the distribution of maximum entropy and its justification in such underdetermined moment problems.Finally, applications to the roll motion of ships serve to exemplify as well as to assess the accuracy and the versatility of the overall method. Response distributions of maxima so predicted compare very well with digital simulation estimates.
    Additional Material: 7 Ill.
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  • 38
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 27 (1989), S. 215-230 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In this paper a mathematical model is presented, based on the application of an averaging technique, in which the equations governing the behaviour of saturated porous media are integrated (averaged) over the smallest dimension of the domain of the problem (thickness). This results in a two dimensional model, in which the three dimensional nature of the problem is accounted for. In fact, the solution is sought in terms of the mean values over the thickness of the field variables and of the transverse displacement components. For the solution of the resulting governing equations a partitioned procedure is employed, which improves the efficiency of the method. The proposed model is very useful in solving problems in which the spatial nature prevents the applications of two dimensional models.Examples are presented, which illustrate the validity of this approach.
    Additional Material: 9 Ill.
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  • 39
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 27 (1989), S. 233-255 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Finite element analysis was used to study the fracture toughening of a ceramic by a stress induced dilatant transformation of second phase particles. The finite element method was based on a continuum theory which modelled the composite as subcritical material. Transient crack growth was simulated in the finite element mesh by a nodal release technique. The crack's remote tensile opening load was adjusted to maintain the near-tip energy release rate at the level necessary for crack advance. The transformation zone surrounding the crack developed as the crack propagated through the composite. Resistance curves were computed from the analysis; and the results show that during crack advance maximum toughness is achieved before a steady state is reached.The toughening effect of a crack-bridging ductile phase in a brittle material may be predicted if ligament deformation is characterized. A plastically deforming ligament constrained by surrounding elastic matrix material is modelled using finite elements and the relevant toughness enhancement information extracted. Comparison is made to model experiments as well as to toughness measured for technologically important materials. The results suggest that debonding along the interface between the ligament and the matrix may enhance the toughening effect of a ductile phase.
    Additional Material: 21 Ill.
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  • 40
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 27 (1989), S. 323-341 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A closed form approach to the assessment of the fatigue life of graphite/epoxy laminates under cyclic tension-compression loading has been developed. The model is mechanistic and uses cyclic energy release rates for prediction of delamination growth and of critical delamination sizes which induce buckling and the final failure of the laminates. Tests performed with graphite/epoxy specimens of stacking order [0n, φm]s with severed central plies [φ], and of stacking order [02, +45, 02, -45, 0, 90]s with a central unloaded hole, indicate good correlation between estimated values and observed delamination growth, critical buckling strength of separated plies and load cycles to failure.
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  • 41
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 429-436 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The paper presents a formulation in the frequency domain for the viscoelastic material behaviour of structural elements. This approach is equally valid for deterministic forces, but also in the case of probabilistic descriptions of those forces. The method takes advantage of readily available experimental data and shows how to introduce them in e.g. finite element formulations.
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  • 42
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 449-452 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 43
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 483-499 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Chebyshev acceleration for a symmetrizable basic iterative method u(n+1) = Gu(n) + k; requires estimates of the extreme eigenvalues m(G) and M(G) of the iteration matrix G. Adaptive procedures are often used in order to obtain good estimates for m(G) and M(G). Some existing adaptive procedures are able to give an estimate of either m(G) or M(G) but not both on any given iteration. In this paper we present an adaptive procedure which can estimate both m(G) and M(G) at the same time and which has other useful properties. Numerical results are given which show the new procedure usually requires fewer iterations than previous procedures.
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  • 44
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 523-546 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The storage requirements and performance consequences of a few different data parallel implementations of the finite element method for domains discretized by three-dimensional brick elements are reviewed. Letting a processor represent a nodal point per unassembled finite element yields a concurrency that may be one to two orders of magnitude higher for common elements than if a processor represents an unassembled finite element. The former representation also allows for higher order elements with a limited amount of storage per processor. A totally parallel stiffness matrix generation algorithm is presented. The equilibrium equations are solved by a conjugate gradient method with diagonal scaling. The results from several simulations designed to show the dependence of the number of iterations to convergence upon the Poisson ratio, the finite element discretization and the element order are reported. The domain was discretized by three-dimensional Lagrange elements in all cases. The number of iterations to convergence increases with the Poisson ratio. Increasing the number of elements in one special dimension increases the number of iterations to convergence, linearly. Increasing the element order p in one spatial dimension increases the number of iterations to convergence as pα, where α is 1·4-1·5 for the model problems.
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  • 45
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 559-570 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A matrix relationship connecting the Jacobi and the Symmetric Successive Overrelaxation (SSOR) matrices associated with a k-cyclic consistently ordered matrix A is presented. Next the equivalence of the SSOR method and a certain monoparametric k-step one for the solution of the linear algebraic system Ax = b is established. The aforementioned equivalence can be exploited to derive regions of convergence, optimum parameters involved, etc. of the two iterative methods above. This is done by studying the simplest of the two methods that is the monoparametric k-step one. To show how the idea works the case k = 2 is very briefly discussed.
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  • 46
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 637-654 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The standard implementations of iterative solvers for finite element and finite difference methods frequently use a diagonal (Jacobi) preconditioner, particularly for element-by-element schemes. However, for such methods the actual order of the condition number with respect to mesh size is not reduced by the preconditioner. In the present paper we describe an iterative method where, in addition, the condition number is reduced by an order of magnitude. Moreover, the scheme may also be implemented as an element-by-element method. The method uses a generalized SSOR preconditioner and a wave front or multi-frontal ordering of the mesh nodes. For a general irregular finite element mesh a striped irregular wave front ordering may be used. The performance of the method as well as various iterative acceleration techniques for a parallel computer are examined in the numerical studies.
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  • 47
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    International Journal for Numerical Methods in Engineering 28 (1989), S. ii 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 48
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 43-73 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper presents a geometrically non-linear formulation (GNL) for the three dimensional curved beam elements using the total Lagrangian approach. The element geometry is constructed using co-ordinates of the nodes on the centroidal or reference axis and the orthogonal nodal vectors representing the principal bending directions. The element displacement field is described using three translations at the element nodes and three rotations about the local axesThe element displacement field has also been described in the literature using Euler parameters, Milenkovic parameters, or Rodriges parameters representing the effects of large rotations.. The GNL three dimensional beam element formulations based on these element approximations are restricted to small nodal rotations between two successive load increments. The element formulation presented here removes such restrictions. This is accomplished by retaining non-linear nodal terms in the definition of the element displacement field, and the consistent derivation of the element properties. The formulation presented here is very general and yet can be made specific by selecting proper non-linear functions representing the effects of nodal rotations. The details of the element properties are presented and discussed. Numerical examples are also presented to demonstrate the behaviour and the accuracy of the elements. A comparison of the results obtained from the present formulation with those available in the literature using a linearized element approximation clearly demonstrate the superiority of the formulation in terms of large load steps, large rotations between two load steps and extremely good convergence characteristics during equilibrium iterations. The displacement approximation of these elements is fully compatible with the isoparametric curved shell elements (with large rotations), and since the elements possess offset capability, these elements can also serve as stiffeners for the curved shells.
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  • 49
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 75-93 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The alternative to quadrature, as a procedure for dealing with the integrations required in the direct boundary element method (DBEM), is to carry out the integration analytically and code the results directly. The potential benefits are efficient computer programs; the avoidance of numerical instability; and generally, better accuracy. The technique is developed in this paper.Serious problems arise when Gauss quadrature is employed for the integration of functions which contain, or are close to singularities. A numerical integration approach may fail at the first stage of the analysis, that is, during the assembly of the discrete equations; or it may fail at the subsequent stage of computing domain points near the boundary. The severity of the problem is dependent both on the strength of the singularity, and on geometry. These points are illustrated with examples.
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  • 50
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 127-144 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The successive quadratic programming (SQP) method is used with the finite element method (FEM) to solve frictionless geometrically non-linear contact problems involving large deformations of the elastica in the presence of flat rigid walls. To formulate the SQP problems, the potential energy (PE) is expanded in a Taylor series of second order in displacement increments about a configuration near a contact solution. The SQP problems consist of minimizing the Taylor expansion of the PE subject to the inequality constraints which represent contact. The quadratic programming (QP) method is made part of a Newton-Raphson (NR) search in which the QP corrections are made when a NR step does not satisfy the constraints. A revised simplex method developed by Rusin is used to solve the QP problems. The elastica is modelled with a total Lagrangian FEM developed by Fried. Solutions are obtained for the end loaded buckled elastica in point contact with a rigid wall and for a uniformly loaded elastica in regional contact with a rigid wall. The problems are also solved using a penalty method. The results obtained for the point contact problem are compared to an analytical solution. Calculations were made to obtain numerical information on maximum load step size and the number of inverse operations required for each load step. Cases in which the elastica stiffened substantially as a result of the initiation of contact are also discussed.
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  • 51
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 261-277 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The basic concept, formulation and numerical application of a fully automatic version of the finite difference method (FDM) on a two-dimensional manifold embedded in three-dimensional Euclidean space are presented. This version of the FDM was developed in order to enable automatic solution of problems formulated in arbitrary curvilinear co-ordinate systems in terms of covariant derivatives (e.g. shell equations).In the classical version of the FDM all operations in the curvilinear co-ordinates (the derivation of base vectors, curvature tensors and so on) have to be performed manually. The goal of the present work was to transfer this job to a computer, in order to minimize the user's effort during the numerical formulation of the physical problem. The relevant version of the fully automatized program FIDAMF, based on the FDM on arbitrary irregular grids,1,2 has been worked out. This code performs automatically all stages of the numerical analysis, starting from the mesh generation and approximation of the shape of the manifold, through computation of necessary objects on this manifold, to the solution of linear or non-linear problems formulated in terms of covariant derivatives.The method has been extended to the analysis of problems in which the co-ordinate system changes during the computation (e.g. the analysis of large deformations in the convectional description). This version of the curvilinear FDM was applied to the analysis of large deformations of hyperelastic membrane shells.The approach and the numerical routines, although used here with the FDM, can be combined with any other approximation method, in particular the finite element method.
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  • 52
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 359-368 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A direct-search optimization strategy, involving pattern-searches, pattern-moves and a simplex algorithm, has been applied to a number of frequency-domain circuit problems. We show that an approximate minimax result can be obtained with our simple approach, which includes using a modified minimax error function. In the examples attempted, the method comes quite close to the accuracy, if not the efficiency, of true minimax optimizers, and yields an accuracy as good as or better than a least-pth (p = 10) gradient optimizer. The method is broadly appropriate wherever it is difficult or inconvenient to calculate the gradients required for conventional minimax optimization.
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  • 53
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 431-443 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The formulation of the recently presented hybrid-Trefftz (HT) p-version elements1 has thus far been restricted to straight-sided polygonal elements. The present paper removes this limitation. Two alternative formulations are studied. In the first one any curvilinear geometry is represented accurately but the rigid body modes are recovered only in the limit as the p-refinement level is increased. In contrast, the second formulation represents the rigid modes exactly while the actual curvilinear geometry is approached with increasing accuracy as the p-refinement level is increased. The practical efficiency of the two alternative approaches is studied and assessed on pertinent examples of thin plates in bending.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 477-478 
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    Keywords: Engineering ; Engineering General
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  • 55
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 483-487 
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  • 56
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 533-560 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper deals with the formulation and the evaluation of a new three node, nine d.o.f. triangular plate bending element valid for the analysis of thick to thin plates. The formulation is based on a generalization of the discrete Kirchhoff technique to include the transverse shear effects. The element, called DST (Discrete Shear Triangle), has a proper rank and is free of shear locking. It coincides with the DKT (Discrete Kirchhoff Triangle) element if the transverse shear effects are not significant. However, an incompatibility of the rotation of the normal appears due to shear effects. A detailed numerical evaluation of the characteristics and of the behaviour of the element has been performed including patch tests for thin and thick plates, convergence tests for clamped and simply supported plates under uniform loading and evaluation of stress resultants. The overall performance of the DST element is found to be very satisfactory.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 593-607 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The introduction of composite materials is having a profound effect on the design process. Because these materials permit the designer to tailor material properties to improve structural, aerodynamic and acoustic performance, they require a more integrated multidisciplinary design process. Because of the complexity of the design process numerical optimization methods are required.The present paper is focused on a major difficulty associated with the multidisciplinary design optimization process - its enormous computational cost. We consider two approaches for reducing this computational burden: (i)development of efficient methods for cross-sensitivity calculation using perturbation methods; and (ii) the use of approximate numerical optimization procedures. Our efforts are concentrated upon combined aerodynamic-structural optimization. Results are presented for the integrated design of a sailplane wing. The impact of our computational procedures on the computational costs of integrated designs is discussed.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 645-666 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A numerical strategy for the simulation of structural modifications by virtual distortions is proposed. Two cases of structural modification are considered: the first concerns modifications of material distribution, and the second modifications of local constitutive relations (e.g. unilateral constraints for stresses or deformations). A formaulation of the fundamental equations of the simulation method is presented. These equations are applicable to the general structural modification problem of a truss-like structure. Then numerical algorithms which refer to particular applications, such as progressive collapse analysis or the analysis of structures with gaps, are discussed.The versatility of the method is illustrated with a number of examples, and the computational advantages of structural modification by the virtual distortion method are discussed.
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  • 59
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 725-726 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 60
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 733-752 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: An adjoint approach is presented for the design sensitivity analysis of transient conduction problems. Variations of a general design functional are expressed in explicit form with respect to all design quantities, i.e. material properties, shape, applied thermal loads including convection, and initial conditions. The methodology incorporates the mutual energy between the real and adjoint thermal problems and a geometric mapping to describe shape variations. Finite element implementation of the method is discussed and an example is provided. Some potential difficulties that might be encountered when using the adjoint method with the finite element method are addressed. These involve the application of impulse loadings and Dirac temperature fields in the adjoint loadings.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 801-815 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In this paper we compare direct and preconditioned iterative methods for the solution of nonsymmetric, sparse systems of linear algebraic equations. These problems occur in finite difference and finite element simulations of semiconductor devices, and fluid flow problems.We consider five iterative methods that appear to be the most promising for this class of problems: the biconjugate gradient method, the conjugate gradient squared method, the generalized minimal residual method, the generalized conjugate residual method and the method of orthogonal minimization. Each of these methods was tested using similar preconditioning (incomplete LU factorization) on a set of large, sparse matrices arising from finite element simulation of semiconductor devices. Results are shown where we compare the computation time and memory requirements for each of these methods against one another, as well as against a direct method that uses LU factorization to solve these problems.The results of our numerical experiments show that preconditioned iterative methods are a practical alternative to direct methods in the solution of large, sparse systems of equations, and can offer significant savings in storage and CPU time.
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  • 62
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 861-877 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The results of a numerical study of swirling and non-swirling combustor flows with and without density variations are presented. Constant-density arguments are used to justify closure assumptions invoked for the transport equations for turbulent momentum and scalar fluxes, which are written in terms of density-weighted variables. Comparisons are carried out with measurements obtained from three different axisymmetric model combustors. The three experiments cover recirculating flow, swirling flow and variable-density, swirling flow inside model combustors. Together, they offer wide ranging flow conditions to test the validity of the models. Results show that the Reynolds stress/flux models do a credible job of predicting constant-density, swirling and non-swirling combustor flows with passive scalar transport. However, their improvements over algebraic stress/flux models are marginal. The extension of the constant-density models to variable-density flow calculations shows that the models are equally valid for such flows. Therefore, the present results argue well for the adoption of constant-density models for variable-density flows until a successfully validated variable-density model is available.
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 37-55 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: With a boundary-fitted curvilinear co-ordinate system, the parabolic approximation is applied to the mildslope equation to describe the wave propagation. Both refraction and diffraction are included in the numerical model. Because the shoreline coincides with one of the curvilinear co-ordinates, the numerical model can be used to compute wave propagations near an irregular shoreline.
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 103-112 
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 129-144 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A global three dimensional model for numerical weather prediction is described. It uses spheric harmonic basis functions with triangular truncation in the horizontal and a finite element discretization for the vertical. Model experiments are used to compare this model with another version, which uses a finite difference scheme for vertical discretization.
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 185-193 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The paper deals with non-Fickian dispersion of inert solutes in random permeability fields. Attention is focused critically on the statistical characterization of the porous medium which affects pollutant dispersion in groundwater. After a brief account of recent results of stochastic theories of transport in porous media and of the fundamental indications of large-scale field experiments, it is inferred from numerical studies that the particular choice of an analytical form of covariance of log-conductivity has a poor influence on the overall dispersion process. In fact, different covariance structures with the same macroscale (a measure of the distance between two points beyond which the permeability ceases to be correlated) yield very similar dispersion processes. The result has a noteworthy bearing on field studies of pollutant dispersion in groundwater because it underlines the reliability of exponential correlation structures yielding analytical expression for time-varying macrodispersion coefficients.
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 231-231 
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    Keywords: Engineering ; Engineering General
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 1803-1812 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A consistent tangent stiffness matrix for the analysis of non-linear contact problems is presented. The associated element has three or four nodes and establishes contact between three-dimensional structures like solids and shells. It accounts for the non-linear kinematics of large deformation analysis and guarantees a quadratic convergence rate. Two formulations, the penalty method and the Lagrange multiplier method, are investigated.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 1855-1874 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: Two domain-by-domain algorithms, suitable for coarse-grained parallel processing analysis of the transient structural dynamics equation, are investigated for accuracy. The application under specific consideration is the analysis of three-dimensional framed structures subjected to time-varying loading. The domain-by-domain approaches attempt to include the advantageous aspects of both conditionally stable explicit algorithms, which require no simultaneous solution of equations and employ simple communication, and unconditionally stable implicit algorithms, which permit large time steps. The alternating group explicit algorithm is developed for finite element analysis, and its accuracy is investigated for a linear formulation. The group implicit algorithm is extended to non-linear finite element analysis, and its accuracy is investigated for the frame dynamics application. Both algorithms are shown to provide inadequate accuracy for practical time step sizes.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 1929-1949 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In this paper we propose an original numerical method to get upper and lower bounds for the eigenfrequencies of an elastic structure.This method is based on a ‘static’ formulation for eigenvalue problems built up from a new quotient Rs which is defined on a load space. From Rs properties, upper and lower bounds for the exact eigenfrequencies are proved. The application of the method requires the solution of an eigenvalue problem of finite dimension and the computation of a constant which is characteristic of the discretization subspace. Results of numerical tests are given for the vibration problem of an elastic clamped membrane.
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  • 71
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 1965-1967 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 1971-1975 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 73
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2041-2058 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The primary goal of this paper is to show how second derivative information can be used in an effective way in structural optimization problems. The basic idea is to generate such an information at the expense of only one more ‘virtual load case’ in the sensitivity analysis part of the finite element code. To achieve this goal a primal-dual approach is employed, that can also be interpreted as a sequential quadratic programming method.Another objective is to relate the proposed method to the well known family of approximation concepts techniques, where the primary optimization problem is transformed into a sequence of non-linear explicit subproblems. When restricted to diagonal second derivatives, the new approach can be viewed as a recursive convex programming method, similar to the ‘Convex Linearization’ method (CONLIN), and to its recent generalization, the ‘Method of Moving Asymptotes’ (MMA).This new method has been successfully tested on simple problems that can be solved in closed form, as well as on sizing optimization of trusses. In all cases the method converges faster than CONLIN, MMA or other approximation techniques based on reciprocal variables.
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  • 74
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2203-2218 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The aim is to build up and test a numerical method to calculate the velocity of stationary two-dimensional flows. Both inviscid and viscous fluids are considered. They act in the unbounded domain surrounding a given profile and a stream function is introduced. A variational procedure, adapted to unbounded domains, reduces the problem to solving a finite sequence of hormonic equations, posed in bounded domains. Some profiles are tested using a finite element method.
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  • 75
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2223-2238 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In this paper, a Mindlin plate element is formulated based on the Hellinger-Reissner principle and the γ-technique. The stiffness consists of a constant stress (one-point quadrature) matrix and a stabilization matrix. The stabilization matrix is compared with those previously proposed. In addition, the element uses a projection to modify the nodal displacements so that the patch test is satisfied. The projection matrix is based on a mode decomposition. Several numerical cases are presented, and it is shown that the mode decomposition projection is necessary both for satisfaction of the patch test and convergence.
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  • 76
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2307-2321 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A method for the time domain identification of modal parameters of a vibrating structure using Z-transformation sequences is presented in this paper.This identification proceeds using the Z-transfer function of a vibrating structure from which an auto-regressive and moving-average (ARMA) model of the vibrating structure is derived. From this ARMA model and time domain data, the modal parameters can be identified. The time domain data can be obtained from single point or multiple shaker excitation modal testing. To demonstrate the application and efficiency of the method, a test on a simulated cantilever beam is presented.
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  • 77
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2361-2381 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The dynamic behaviour of a saggy suspension cable under a moving load was investigated. First of all, the updated Lagrangian formulation and the finite element method were used to derive the property matrices of a saggy suspension cable in order to define the discretized equations of motion. Then, the Jacobi method was applied to the determination of the natural frequencies and the mode shapes of the suspended cable. The moving-load-induced dynamic responses of the saggy suspended cable were obtained by using the Newmark direct integration method incorporated with the Newton-Raphson iteration technique. The influence of some pertinent factors, such as speed of moving load, ratio of axial rigidity to total cable weight (AE/0m̄g0L) and ratio of moving load mass to total cable mass, is the key point of the dynamic analysis.
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  • 78
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 211-236 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An a posteriori error estimator is presented which allows a good pointwise evaluation of the error in predicted stresses and can easily be implemented in existing FE codes. Although this estimator has especially been developed for and tested on p-version Hybrid-Trefftz (HT) elements, it is anticipated that it can also be applied to conventional conforming p-version elements. The practical efficiency of the estimator is illustrated through the solution of various plate bending problems by using the HT p-version Kirchhoff plate elements.2
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  • 79
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 245-260 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A numerical model is developed for computing two-dimensional circulation in coastal regions dominated by large tidal flat motion. This model is based on the shallow water momentum and continuity equations being operated upon by the Galerkin finite element method. The particular advantage of the model lies in its ability to accommodate a changing domain boundary. This is accomplished by adopting finite elements that change shape so as to consistently move with the water's edge. Application of the model to the Kuwait Bay is described, and the associated results on circulation are given.
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  • 80
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 315-329 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Electrostatic charging inside a tank is analysed numerically using the boundary integral method. The electrostatic charge is transmitted to the tank through a charged liquid. Profiles for the charge density and potential are obtained in the tank during the filling operation. The analysis is based on the equation governing the transport of charge and Poisson's equation. The results are characterized by two dimensionless parameters, the dimensionless Debye length given by the Debye length divided by the height of the tank, and the number Pe defined as a Peclet number. The results show where the maximum charge density and potential occur and give a prediction of when during the filling operation a hazardous situation may occur.
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  • 81
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 385-414 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: An assumed strain (strain interpolation) method is used to construct a stabilization matrix for the 9-node shell element. The stabilization procedure can be justified based on the Hellinger-Reissner variational method. It involves a projection vector which is orthogonal to both linear and quadratic fields in the local co-ordinate system of each quadrature point. All terms in the development involve 2 × 2 quadrature in the 9-node element. Example problems show good accuracy and an almost optimal rate of convergence.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2695-2707 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: This paper investigates the possibility of integrating the two currently most popular mesh generation techniques, namely the method of advancing front and the Delaunay triangulation algorithm. The merits of the resulting scheme are its simplicity, efficiency and versatility. With the introduction of ‘non-Delaunay’ line segments, the concept of using Delaunay triangulation as a means of mesh generation is clarified.An efficient algorithm is proposed for the construction of Delaunay triangulations over non-convex planar domains. Interior nodes are first generated within the planar domain. These interior nodes and the boundary nodes are then linked up together to produce a valid triangulation. In the mesh generation process, the Delaunay property of each triangle is ensured by selecting a node having the smallest associated circumcircle. In contrast to convex domains, intersection between the proposed triangle and the domain boundary has to be checked; this can be simply done by considering only the ‘non-Delaunay’ segments on the generation front.Through the study of numerous examples of various characteristics, it is found that high-quality triangular element meshes are obtained by the proposed algorithm, and the mesh generation time bears a linear relationship with the number of elements/nodes of the triangulation.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2713-2714 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 84
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2715-2760 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: In Part I of this paper,1 the conceptual framework of a rate variational least squares formulation of a continuously deforming mixed-variable finite element method was presented for solving a single evolution equation. In Part II2 a system of ordinary differential equations with respect to time was derived for solving a system of three coupled evolution equations by the deforming grid mixed-variable least squares rate variational finite element method. The system of evolution equations describes the coupled heat flow, fluid flow and trace species transport in porous media under conditions when the flow velocities and constituent phase transitions induce sharp fronts in the solution domain. In this paper, we present the method we have adopted to integrate with respect to time the resulting spatially discretized system of non-linear ordinary differential equations. Next, we present computational results obtained using the code in which this deforming mixed finite element method was implemented. Because several features of the formulation are novel and have not been previously attempted, the problems were selected to exercise these features with the objective of demonstrating that the formulation is correct and that the numerical procedures adopted converge to the correct solutions.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2839-2853 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The Zienkiewicz-Zhu error estimator is shown to be effective in problems of plate flexure. When used in conjunction with triangular elements and an adaptive mesh generator allowing a prescribed size of elements to be developed, very fast adaptive convergence for results of specified accuracy is achieved.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2889-2906 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The construction of changing sequences of irregular and nested triangulations, based on the use of conforming refinement/derefinement algorithms for triangulations, is presented and discussed. This strategy is particularly appropriate to combine adaptivity and full multigrid algorithms for dealing with moving fronts or fluid dynamics problems. It is shown that the quality of all the triangulations iteratively generated depends only on the geometric characteristics of the initial grid. A data structure suitable to create, manage and modify series of nested triangulations as well as the main features of the DEREF prototype package are described, and numerical examples are given.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2923-2941 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A unified presentation of some popular continuation procedures used in the non-linear finite element analysis of structural mechanics is introduced. An extension of the elliptical constraint equation proposed by Crisfield is given. It is shown that in the proposed procedure real roots can always be obtained in solving the iterative change of the load parameter. Updated weighting factors are introduced in the constraint equation in order to get better convergence characteristics in the case when localized deformations occur. For bifurcation points a modification of Rheinboldt's branching procedure is presented. Post critical response after limit and bifurcation points is determined in some numerical examples.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2191-2202 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This note reports numerical experiments on the efficiency of simple error estimates derived earlier1 applied to incompressible mixed or related penalty type formulations. The rate of convergence and performance of various mixed elements is compared. Numerical results from a driven cavity and an incompressible elastic problem demonstrate that the T6B1/3D and T6/3C elements give a faster rate of convergence than the T6/1D element. However, in the case of a plane extrusion analysis (stronger singularity), the rate of convergence for the T6B1/3D element drops and is inferior to that of the T6/1D, while the T6/3C element still proves superior to the other two elements.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2239-2255 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Timoshenko's and Vlasov's beam theories are combined to produce a C0 finite element formulation for arbitrary cross section thin-walled beams. Section properties are generated using a curvilinear co-ordinate system to describe the cross section dimensions. The element includes both shear and warping deformations caused by the bending moments and the bimoment. A Gauss quadrature order is employed which exactly integrates the bending and warping stiffness matrices and provides a reduced integration order for the shear stiffness matrices. Numerical results are presented for a channel section cantilever beam. The influence of shear deformation is investigated and the calculated results are shown to be in excellent agreement with the classical solutions.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 929-942 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The virtual crack extension technique is a very efficient and accurate approach to fracture mechanics calculations in the numerical analysis of bodies containing cracks using the finite element method. A few variations of the technique have been described in the literature, and have been extensively used in linear elastic fracture mechanics, where good validation has frequently been available with accepted alternative solutions for standard tests. However, for non-linear materials extra complications arise in the technique, particularly in describing material response in a compatible manner. It is shown that, using few assumptions, a very competitive virtual crack extension technique based, on a direct minimization of potential energy is available for elastic non-linear elastic materials. Such materials can be closely approximated to elastic-plastic behaviour for monotonically increasing loads including mechanical, thermal and body force forms. The technique is described and demonstrated via examples to be in good agreement with alternative fracture parameter evaluations when evaluated in the same computer system, BERSAFE.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 979-979 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 92
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 71-85 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A study of linear monochromatic wave propagation is presented, based on a theory of potentials. The usual Berkhoff equation has been extended by the addition of partially pervious solid boundary effects and the bed friction.The problem has been solved by a hybrid finite element method including the effect of singular local elements such as the end of breakwaters or wharfs. This numerical method confirms the interest in quadratic Lagrangian finite elements.The comparisons with analytical solutions and existing numerical results show the validity of the method. Some original examples also prove the good performance of the proposed computation method.As an example, the study of the erosion of the beach of Calvi Bay in Corsica, France is presented. The phenomenon had started already in 1960, but the problem began to be very severe four years ago, after the implementation of a new harbour in 1982 and buildings, hotels, restaurants, and a main sewer on the beach. To consider the impact of these constructions and other factors like waves, currents and geomorphological aspects, the studies were divided into four parts: sedimentological, currents, wave propagation and geomorphological.This paper will describe the results of a complete two years study on the site, from February 1986 to December 1987.Findings show that the erosion process is due to the rise of the relative sea level with, as a catalyst, tourist behaviour and the implementation of the new constructions.
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    International Journal for Numerical Methods in Engineering 27 (1989), S. 153-167 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: Jacket structures have many sub-sea appurtenances attached to them. For example, a typical jacket structure has hundreds of sacrificial anodes attached to its members. The fluid loading of these structures is calculated using Morison's formula. The force coefficients used in the equation are based on experiments carried out, for the most part, on single cylinders in laboratories in ideal flow. There are very few experimental data available for the fluid loading of cylinders with appurtenances. Moreover, it is not possible to calculate theoretically the loading on such configurations in flows of practical interest using approaches such as the finite element method. However, appurtenances can contribute significantly to the overall loading on a structure. This paper presents the preliminary theoretical work that has been carried out as part of a programme to establish a rational method for estimating the fluid loading on tubular members with appurtenances.
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    International Journal for Numerical Methods in Engineering 27 (1989) 
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2943-2946 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 331-358 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The finite strip method is applied to the non-linear analysis of plate structures. Large deflection effects are included via first order non-linearities in the strain-displacement relations, and material non-linearities are included via the von Mises yield criterion and associated flow rule. The virtual work equations are integrated numerically using Gauss quadrature, and the resulting non-linear equations are solved by Newton-Raphson iteration. Numerical results are presented for many applications including uniformly loaded rectangular and I beams, and square plates with either simply supported or clamped ends (or edges). The results are compared with known results from analytical and/or finite element analyses. Finally, a uniformly loaded stiffened panel is analysed and the results are compared with finite element results. In all cases, the results indicate that a single bending mode in the strip direction is sufficient to yield engineering accuracy for design purposes.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. ii 
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    Keywords: Engineering ; Engineering General
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2257-2273 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A multi-domain method of solving three-dimensional elastic crack problems in an infinite elastic body using the boundary element method is proposed. The \documentclass{article}\pagestyle{empty}\begin{document}$ \sqrt r $\end{document} displacement and \documentclass{article}\pagestyle{empty}\begin{document}$ 1/\sqrt r $\end{document} traction behaviours near a crack front are incorporated in special crack elements. The elimination of singularities arising from the \documentclass{article}\pagestyle{empty}\begin{document}$ 1/\sqrt r $\end{document} term combined with Kelvin's kernel for displacement in the integrals is discussed in detail. Stress intensity factors of modes I, II and III are obtained directly from crack-front nodal values, without any extrapolation as in some other methods. No differentiation of conventional boundary integral equations (with Kelvin's tensor kernels) is necessary in the current approach. This method is applicable to cracks of arbitrary shape. Infinite bodies are modelled precisely as such, not approximated as large finite bodies. Numerical solutions of stress intensity factors are given for several problems involving a penny-shaped crack.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2339-2360 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: Structural analysis often involves the solution of a sparse system of linear equations using matrix factorization. For structural reanalysis problems, the system of equations is progressively changing and matrix factorization is required at each iteration step. In this paper, we study the problem of updating the structure of sparse matrix factors using an ordered-tree model. The ordered-tree model provides the information needed to symbolically compute the non-zero structure of the matrix factor of a sparse matrix. Furthermore, for matrix factor modification problems, this tree model can be used to determine the numerically modified entries in the matrix factor. Examples for modification of a structure and h-adaptive refinement of a finite element model are given to illustrate the potential application of the procedures developed in this study.
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    International Journal for Numerical Methods in Engineering 28 (1989), S. 2423-2449 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The development of a general boundary element method (BEM) for two- and three-dimensional quasistatic poroelasticity is discussed in detail. The new formulation, for the complete Biot consolidation theory, operates directly in the time domain and requires only boundary discretization. As a result, the dimensionality of the problem is reduced by one and the method becomes quite attractive for geotechnical analyses, particularly those which involve extensive or infinite domains.The presentation includes the definition of the two key ingredients for the BEM, namely, the fundamental solutions and a reciprocal theorem. Then, once the boundary integral equations are derived, the focus shifts to an overview of the general purpose numerical implementation. This implementation includes higher-order conforming elements, self-adaptive integration and multi-region capability. Finally, several detailed examples are presented to illustrate the accuracy and suitability of this boundary element approach for consolidation analysis.
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