Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles: DFG German National Licenses  (21)
  • 1995-1999  (21)
  • 11
    Electronic Resource
    Electronic Resource
    Mianserin-induzierte Hypertonie 2 Wochen nach Absetzen von Tranylcypromin (1997)
    Springer
    Der Nervenarzt 68 (1997), S. 591-592 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Mianserin ; Tranylcypromin ; Kardiale Vorschädigung ; Hypertone Blutdruckwerte ; Key words Mianserin ; Tranylcypromine ; Cardiac disease ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary As compared to other tri- and tetracyclics, antidepressant therapy in patients suffering also from cardiac disease with mianserin is known to be relatively safe. Hypertensive effects of mianserin have not been described so far. We report a case of a 64 years old patient with a dilatative cardiomyopathy and left anterior hemiblock, who developed hypertension (maximum: 180/125 mmHg) during mianserin treatment. Previous treatment with tranylcypromine has been stopped two weeks before. After discontinuance of mianserin blood pressure rapidly came back to normal values. The possible noradrenergic and serotonergic mechanisms of this phenomenon are discussed in relation to pretreatment with tranylcypromine.
    Notes: Zusammenfassung Mianserin gilt in der antidepressiven Behandlung von kardial vorgeschädigten Patienten im Vergleich zu anderen tri- und tetrazyklischen Antidepressiva als eher unbedenklich. Blutdrucksteigernde Wirkungen sind nicht zu erwarten. Im dargestellten Fall wurde ein 64jähriger Patient mit vorbekannter dilatativer Kardiomyopathie und Linksschenkelblock nach Vorbehandlung mit Tranylcypromin auf Mianserin umgestellt, woraufhin sich eine medikamentös nur schwer zu beeinflussende hypertone Blutdrucksteigerung (Maximum: 180/125 mmHg) entwickelte. Nach Absetzen von Mianserin kam es zu einer raschen Blutdrucknormalisierung. Die der Blutdrucksteigerung zugrundeliegenden möglichen noradrenergen und serotonergen Wirkmechanismen werden auf dem Hintergrund der Vorbehandlung mit Tranylcypromin diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050166
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    Das postoperative Delir Risikofaktoren, Prophylaxe und Therapie (1999)
    Springer
    Der Anaesthesist 48 (1999), S. 507-518 
    Details
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Postoperatives Delir ; Postoperative psychiatrische Störungen ; Therapie ; Prophylaxe ; Key words Postoperative delirium ; Postoperative psychiatric disturbance ; Treatment ; Prophylaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract After surgical operations delirium can occur as a serious and possible lethal complication in about 5–15% of patients. Additionally, risk factors such as old age, polymedication, organic and psychiatric diseases raise the incidence. After open-heart- and orthopedic surgery more than half of the patients are affected. Delirium has negative effects on postoperative mobilization and reconvalescence and prolongs treatment on the ward. It is discussed in the literature that delirium may induce dementia in older patients. The correction of metabolic- and electrolyte imbalances, as well as the therapy of neurologic and psychiatric diseases, belongs to prophylactic treatment. Environmental conditions which facilitate reorientation of the patient after operation have beneficial effects. Some success has been achieved by using the nootropic substance piracetam as a prophylactic. In acute treatment, the butyrophenon-neuroleptic haloperidol is the drug of choice. In delirium caused by intoxication with anticholinergic agents, physostigmin is indicated. Benzodiazepines, clonidine and clomethiazole are used in particular for the treatment of withdrawal delirium.
    Notes: Zusammenfassung Nach operativen Eingriffen kommt es bei 5 bis 15% der Patienten zu einem Delir, welches eine ernste und potentiell tödliche Komplikation darstellt. Bei zusätzlich bestehenden Risikofaktoren wie hohem Alter, medikamentöser Mehrfachtherapie, somatischen und psychiatrischen Störungen findet sich eine noch wesentlich höhere Inzidenz. Bei Operationen am offenen Herzen und orthopädischen Eingriffen sind über die Hälfte der Patienten betroffen. Das Delir beeinträchtigt die postoperative Mobilisierung und Rekonvaleszenz der Patienten und führt zur Verlängerung des stationären Aufenthalts. Die Gefahr einer dementiellen Entwicklung als Spätfolge des Delir bei älteren Patienten wird in der Literatur diskutiert. Zu den Maßnahmen der Prophylaxe zählen die Behandlung von metabolischen Entgleisungen, Ausgleich von Elektrolytstörungen und Therapie von neurologischen und psychiatrischen Erkrankungen. Verhaltensmaßnahmen, die die Orientierung des Patienten nach der Operation erleichtern, haben eine günstige Wirkung. Erfolge wurden durch die prophylaktische Verabreichung des Nootropikums Piracetam berichtet. In der Akutbehandlung ist das Butyrophenon-Neuroleptikum Haloperidol Mittel der Wahl zur Sedierung. Bei Delirien auf der Grundlage einer Intoxikation mit anticholinerg wirkenden Pharmaka ist Physostigmin indiziert. Benzodiazepine, Clonidin und Clomethiazol kommen v.a. bei der Behandlung des Entzugsdelir zum Einsatz.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001010050741
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    Beeinflussung der Phenprocoumonwirkung durch trizyklische Antidepressiva (1999)
    Springer
    Zeitschrift für Herz-, Thorax- und Gefässchirurgie 13 (1999), S. 139-146 
    Details
    ISSN: 0930-9225
    Keywords: Schlüsselwörter Antikoagulantien – Phenprocoumon – Antidepressiva – Arzneimittelinteraktion ; Key words Anticoagulation – phenprocoumon – antidepressants – drug-drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A potential impact of tricyclic antidepressants on oral anticoagulation is controversial. Phenprocoumon – the most commonly used anticoagulant in Germany – is rarely considered in clinical trials. In the present study, a potential drug-drug interaction between phenprocoumon and tricyclics, causing an alteration in prothrombinemic effects, has been investigated. In eleven patients simultaneously receiving tricyclic antidepressants and phenprocoumon the course of Quick values and the phenprocoumon dosages were compared to a control group of eleven phenprocoumon treated patients not receiving tricyclics. Quick value deviations from the individually required therapeutic ranges 〉25%, as well as frequent changes in the phenprocoumon dosages were indicators of an inconstant oral anticoagulation and a possible interaction. The results showed unstable prothrombinemic effects throughout tricyclic antidepressant therapy. The average Quick value deviation amounted to 68.7% in the patients group and to 13.1% in the control group. Additionally, there was an average change in phenprocoumon dosage of 0.6 in the patients group and of 0.2 in the control group. Further controlled studies are certainly warranted to specifically answer the question of a clinically relevant drug-drug interaction.
    Notes: Zusammenfassung Eine mögliche Beeinflussung der Antikoagulanzientherapie durch trizyklische Antidepressiva wird bislang unterschiedlich bewertet. Vor allem das in Deutschland therapeutisch eingesetzte Antikoagulanz Phenprocoumon bleibt bei Untersuchungen nahezu unberücksichtigt. Die vorliegende retrospektive Studie wurde unter der Fragestellung einer potentiellen Arzneimittelinteraktion zwischen Phenprocoumon und Trizyklika durchgeführt. Bei 11 gleichzeitig mit Trizyklika und Phenprocoumon behandelten Patienten und 11 antikoagulierten Kontrollen ohne antidepressive Therapie erfolgte eine Gegenüberstellung von Quickwertverlauf und Phenprocoumondosis während und außerhalb trizyklischer Therapie. Quickwertabweichungen vom therapeutischen Bereich 〉25% und häufige Phenprocoumon-Dosiswechsel galten als Zeichen einer instabilen Antikoagulation und einer zugrundeliegenden Interaktion. Sowohl im intraindividuellen Patientenvergleich wie auch in der Gegenüberstellung von Patienten- und Kontrollkollektiv wurde eine instabile Phenprocoumonwirkung unter Trizyklikatherapie gezeigt. Die mittlere Quickwertabweichung [mQWA] betrug im Patientenkollektiv 68,7%, im Kontrollkollektiv 13,1%. Für das Patientenkollektiv wurde eine mittlere Dosiswechselzahl [mDWZ] von 0,6 errechnet. Im Kontrollkollektiv lag die mDWZ bei 0,2. Inwiefern unsere Beobachtungen als Indikator einer potentiellen Arzneimittelinteraktion gelten können, ist in diesem Rahmen nicht abschließend zu beurteilen. Zur endgültigen Abklärung der Fragestellung erscheint die Durchführung prospektiver Studien angezeigt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003980050071
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    Improvement of acute exacerbations of schizophrenia with amisulpride: a comparison with haloperidol (1997)
    Springer
    Psychopharmacology 132 (1997), S. 396-401 
    Details
    ISSN: 1432-2072
    Keywords: Key words Amisulpride ; Atypical antipsychotic ; Schizophrenia ; Haloperidol ; Productive symptoms ; Secondary negative symptoms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Amisulpride is a substituted benzamide with high selectivity for dopaminergic D2 and D3 receptors. This study compared 800 mg/day amisulpride and 20 mg/day haloperidol in patients with acute exacerbations of schizophrenia. This multicenter, double-blind trial involved 191 patients allocated, after a 1 to 7-day wash-out period, to amisulpride (n = 95) or haloperidol (n = 96) for 6 weeks. Improvement of mean BPRS total score was 48% for amisulpride and 38% for haloperidol (NS), whereas improvement in the Negative PANSS subscale was greater in the amisulpride group (37%) compared to haloperidol (24%) (P = 0.038). CGI scores showed a higher number of responders in the amisulpride (62%) than in the haloperidol group (44%) (P = 0.014). More extrapyramidal symptoms measured with the Simpson-Angus scale were provoked in the haloperidol group (P = 0.0009). Amisulpride is at least as effective as haloperidol in the treatment of acute exacerbations of schizophrenia, and is more effective in the treatment of negative symptoms whilst causing less parkinsonism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050361
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 15
    Electronic Resource
    Electronic Resource
    SPECT patterns in probable Alzheimer’s disease (1999)
    Springer
    European archives of psychiatry and clinical neuroscience 249 (1999), S. 190-196 
    Details
    ISSN: 1433-8491
    Keywords: Key words HMPAO-SPECT ; Alzheimer’s disease ; Hypoperfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The primary objective of this study was to test hypotheses about the relationship between HMPAO-SPECT findings and probable Alzheimer’s disease (DAT) in a relatively large sample of patients diagnosed according to DSM-III-R. SPECT patterns of 20 controls and 116 DAT patients were investigated. Left and right frontal, temporal, parietal and occipital regions of the brain were rated as showing a hypoperfusion or not. A wide variety of patterns were found and these are described in detail below. In DAT patients, temporal and/or parietal regions were affected significantly more often (88%, p 〉 0.001) than frontal and/or occipital regions (70%). A bilateral temporoparietal pattern, which has been repeatedly reported as typical for DAT, was observed in 48% of DAT patients, but also in 25% of controls, and did not differentiate significantly between these two groups (p 〉 0.05). Conversely, more than three regions with hypoperfusion were observed significantly more often in DAT patients (48%, p 〈 0.01) than in controls (10%). In DAT patients, the number of regions with hypoperfusion correlated significantly with the score of the Mini Mental State Examination (MMSE, r = 0.33, p 〈 0.001). The frequency of at least one hypoperfusion was approximately equal in left and right hemispheres (77% vs. 73%, p = 0.2). The hypothesis that cognitive decline in DAT starts in the temporal regions was tested in 14 SPECT patterns showing only one region with hypoperfusion. In 12 of these patterns, a temporal region was in fact affected (p 〈 0.001). Whereas hypoperfusion in frontal areas was not accompanied by a significantly lower MMSE than when only temporoparietal regions were affected, MMSE scores were significantly lower when occipital regions were affected in addition to temporoparietal regions (p 〈 0.05). The clinical use of SPECT findings was tested in discriminating analyses with the MMSE and a delayed recall test as additional predictors of DAT. Whereas the MMSE and the delayed recall test differentiated significantly between DAT patients and controls, SPECT findings yielded no further differentiation. In conclusion, the theoretical and clinical implications of SPECT findings and their relationships to other physiological and psychological variables deserve further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004060050086
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 16
    Electronic Resource
    Electronic Resource
    Review: Treatment of schizophrenia (1996)
    Springer
    European archives of psychiatry and clinical neuroscience 246 (1996), S. 229-234 
    Details
    ISSN: 1433-8491
    Keywords: Treatment of schizophrenia ; Negative symptoms ; Neuroleptics ; Psychosocial therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract As a result of the multifactorial etiopathology of schizophrenia, a treatment strategy combining drug therapy with psychosocial measures is indicated. Depending on the stage of the disease and on the individual condition of the patient, the accent is set alternatively more on one approach or on the other. However, under aspects of symptom reduction and relapse prophylaxis, the therapy with neuroleptics plays the most important role. In order to keep their side effects to a minimum during acute and long term treatment, there is nowadays a trend towards administration of the lowest possible dose. Under this aspect, the use of so called atypical neuroleptics should be taken into consideration. The treatment of negative symptoms, especially in the context of chronic residual syndrome, is still a problem which hasn't been solved to satisfaction. Beside the use of atypical neuroleptics, treatment with antidepressives should be tried. During the long term relapse prophylactic treatment, it is important that not only the criterion “reduction of the relapse rate” but also that of individual risk/benefit relation be considered. Concerning psychosocial therapies, especially focused behavioural therapy approaches, for example educational programs and specific family therapeutical intervention following the high-EE-concept, as well as training of social and cognitive competences have proved useful beside supportive psychotherapy and the whole range of sociotherapeutical measures. However they need further evaluation before they get integrated in routine treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02190273
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 17
    Electronic Resource
    Electronic Resource
    The case described by Alois Alzheimer in 1911 (1998)
    Springer
    European archives of psychiatry and clinical neuroscience 248 (1998), S. 111-122 
    Details
    ISSN: 1433-8491
    Keywords: Key words Alzheimer’s disease ; Dementia ; “Plaque-only” Alzheimer’s disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 1906, Alzheimer presented the first case of the disease which was later named Alzheimer’s disease by Kraeplin. While the publication on this case in 1907 is only a relatively short communication, Alzheimer published a very comprehensive paper in 1911 in which he discussed the concept of the disease in detail. This publication focusses on the report of a second patient suffering from Alzheimer’s disease, the case of Johann F. The detection of neurohistopathological sections from this patient found among archives at the Institute of Neuropathology of the University of Munich enabled us to reinvestigate this case using modern methods. Neurohistopathologically, the case of Johann F. is “plaque-only” Alzheimer’s disease. There is a controversy in the modern literature as to whether these “plaque-only” cases belong to the modern concept of Alzheimer’s disease. A careful analysis of all pros and contras in the literature led to the conclusion that plaque-only cases are also an integrative part of the modern Alzheimer disease concept.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004060050027
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 18
    Electronic Resource
    Electronic Resource
    Corpus callosum size in schizophrenia – a magnetic resonance imaging analysis (1999)
    Springer
    European archives of psychiatry and clinical neuroscience 249 (1999), S. 305-312 
    Details
    ISSN: 1433-8491
    Keywords: Key words Corpus callosum ; Schizophrenia ; MRI ; Etiology of schizophrenia ; Family history
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous MRI studies have shown differences in corpus callosum size between schizophrenic patients and controls. The corpus callosum (CC), as the main interhemispheric fiber tract, plays an important role in interhemispheric integration and communication. Though MRI studies suggest smaller CC in schizophrenia, there are still conflicting findings. Using in vivo magnetic resonance imaging, it was investigated whether the midsagittal area of CC differs between twenty-three right-handed male schizophrenic patients and twenty-three matched controls. Total CC area, five subregions of CC, total brain volume, gray and white matter were measured. No differences between schizophrenic patients and controls were found regarding all CC measurements, total brain volume, and gray matter tissue. However, a significant reduction of white matter tissue in the patient group emerged. There was no correlation between CC morphology and clinical variables such as age of onset, length of illness or symptom severity. Interestingly, five schizophrenic patients with a positive family history of schizophrenia showed significant reduction of the subregion C3, associated with a reduced total brain and gray and white matter volume. Significant reduction in the CC and its subregions was not confirmed in this group of patients with schizophrenia. In the subgroup of schizophrenic patients with a positive family history of schizophrenia, a significant reduction of the subregion corresponding to a part of the trunk of the CC was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004060050104
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 19
    Electronic Resource
    Electronic Resource
    The prophylactic efficacy of lithium – transient or persistent? (1999)
    Springer
    European archives of psychiatry and clinical neuroscience 249 (1999), S. 144-149 
    Details
    ISSN: 1433-8491
    Keywords: Key words Depression ; Bipolar disorder ; Lithium ; Prophylaxis ; Efficacy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been reported recently that the prophylactic efficacy of lithium is a transient phenomenon in many patients. Other studies suggest sustained efficacy against affective recurrences for many years. As this issue is of major therapeutic relevance, published literature considering changes in lithium efficacy over time has been reviewed. The present review includes a critical evaluation of the data and the methodology which yielded these controversial results. Considering the published data discussed in this review, the balance of evidence does not indicate a general loss of lithium efficacy in the prophylaxis of major affective disorders. A supposed persistence of the prophylactic effects in general does not, however, exclude the reappearance of affective recurrences after years of successful treatment in individual cases. Possible reasons for this phenomenon are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004060050079
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 20
    Electronic Resource
    Electronic Resource
    Das Verhaltenstherapeutische Kompetenztraining VKT – Eine spezifische Intervention für Patienten mit einer beginnenden Alzheimer-Demenz (1998)
    Springer
    Zeitschrift für Gerontologie + Geriatrie 31 (1998), S. 112-119 
    Details
    ISSN: 0044-281X
    Keywords: Schlüsselwörter Verhaltenstherapeutisches Kompetenztraining VKT – Psychotherapie – Alzheimer-Demenz ; Key words Behavioral competency training – Verhaltenstherapeutisches Kompetenztraining VKT – psychotherapy – Alzheimer disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary At the Psychiatric Department, Ludwig-Maximilians-Universität, Munich, a behavioral competency training (Verhaltenstherapeutisches Kompetenztraining) VKT is offered to patients with early stages of Alzheimer's disease (AD). The primary objects of VKT are, (a) patient support in coping with the diagnosis of AD, (b) mobilization of the present personal activity ressources, and (c) minimization of depressive symptoms. The VKT consits of six therapymodules: 1. behavior analysis, 2. psychoeducation, 3. stressmanagement, 4. increase of pleasant activities, 5. enhancement of social competency, and 6. modification of depressive cognitive patterns. The VKT is derived from scientific findings that show the involvement of psycho-social factors in the genesis of AD. Inadequate coping-behavior, unescapable stress and resulting neurodegenerative effects, a low premorbid niveau of activity and the presence of premorbid depressive symptoms outline the necessity of psychotherapeutic treatment in AD patients.
    Notes: Zusammenfassung An der Psychiatrischen Klinik und Poliklinik der Ludwig-Maximilians-Universität München bieten wir unseren Patienten mit einer beginnenden Alzheimer-Demenz (AD) ein Verhaltenstherapeutisches Kompetenztraining (VKT) an. Das VKT hat zum Ziel, (a) den Patienten bei der Bewältigung der Belastungen zu unterstützen, die sich aus der Erkrankung selbst sowie aus der Stellung der Diagnose ergeben; (b) durch die Mobilisierung vorhandener persönlicher Ressourcen zu vermeiden, daß der Patient im Frühstadium der Erkrankung in einem stärkeren Maße deaktiviert wird, als dies aufgrund seiner tatsächlichen neuropsychologischen Defizite gerechtfertigt ist; und (c) depressiven Symptomen entgegenzuwirken. Das VKT ist für ein Einzel- oder Kleingruppensetting konzipiert und setzt sich aus sechs Therapiemodulen zusammen: 1. Therapieplanung und Verhaltensanalyse, 2. Psychoedukation, 3. Streßmanagement, 4. Aktivitätenaufbau, 5. Förderung sozialer Kompetenz und 6. Modifikation depressiogener Kognitionen. Die Festlegung der Übungsinhalte des VKT begründet sich auf Forschungsergebnissen, die zeigen, daß an der Entwicklung einer AD psychosoziale Faktoren beteiligt sind. Mangelndes Coping-Verhalten bei unkontrollierbarem Streß und resultierende neurodegenerative Effekte, ein geringes prämorbides Aktivitätsniveau sowie das Auftreten prämorbider depressiver Symptome unterstreichen die Notwendigkeit einer psychotherapeutischen Behandlung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003910050026
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...