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  • 1
    Electronic Resource
    Electronic Resource
    Simultaneous occurrence of perimembranous glomerulonephritis and glomerular amyloidosis (1978)
    Springer
    Virchows Archiv 378 (1978), S. 315-320 
    Details
    ISSN: 1432-2307
    Keywords: Perimembranous glomerulonephritis ; Glomerular amyloidosis ; Therapy with D-penicillamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The results of electron microscopic examination of renal biopsies from 3 patients with rheumatoid arthritis treated with penicillamine are presented. All 3 patients developed a nephrotic syndrome upon discontinuation of penicillamine therapy. When viewed with the electron microscope, segmental forms of perimembranous glomerulonephritis (Stages I–II of Ehrenreich and Churg) and glomerular renal amyloidosis Grade I–III were observed. In all three cases the nephrotic syndrome was considered to be due to the simultaneous occurrence of the two disease processes. In 2 cases perimembranous glomerulonephritis with immuno-complex-deposits was assumed to be the dominant factor in the causation of the disease, in the other case amyloidosis was the principle abnormality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00465597
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  • 2
    Electronic Resource
    Electronic Resource
    The morphological and clinical features of membranoproliferative glomerulonephritis in adults (1974)
    Springer
    Virchows Archiv 363 (1974), S. 213-224 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A study of 110 patients with membranoproliferative glomerulonephritis (MPGN) revealed that this disease appears in a simple form and in a lobular form. Both forms are characterized by a differently severe proliferation of mesangial cells and by a mostly extensiv thickening of the glomerular basement membrane. The proliferation of mesangial cells and thickening of the glomerular basement membrane is more severe in the lobular form of MPGN. Dense deposit lesions were observed in association with both the simple form and the lobular form of MGPN. An analysis of the morphological and clinical features of MPGN in patients with dense deposits in the glomerular capillary walls failed to indicate that dense deposits represent a unique disease entity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432802
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  • 3
    Electronic Resource
    Electronic Resource
    Weitere Befunde zur sog. Transplantatadaptation menschlicher Nieren (1970)
    Springer
    Virchows Archiv 349 (1970), S. 170-178 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Untersuchung von Fibroblasten bzw. fibroblastenartigen Zellen mit Barrschen Zellkernkörpern im perivasculären und intertubulären Gewebe von 16 Nierentransplantaten, die 14 Tage bis 1 1/2 Jahre nach der Übertragung zum Teil bei guter Funktion entfernt worden waren, führten zu folgenden Ergebnissen: 1. In 7 männlichen Spendernieren, die auf weibliche Empfänger übertragen worden waren, zeigten 9–14% der Fibroblasten bzw. fibroblastenartigen Zellen im Niereninterstitium Barrsche Zellkernkörper. 2. Bei der Konstellation Empfänger männlich — Spender weiblich schwankte der Prozentsatz von sog. Fibroblasten mit Barrschem Zellkernkörper zwischen 14 und 17%. 3. In weiblichen Spendernieren, die auf weibliche Empfänger transplantiert worden waren, wurden zwischen 15 und 22% „Fibroblasten“ mit Barrschen Zellkernkörpern gezählt. 4. Bei der Konstellation Empfänger und Spender männlich betrug die Zahl der Zellen mit Barrschen Zellkernkörpern in obiger Lokalisation 0,3–0,6%. Aus diesen Befunden wird gefolgert, daß im perivasculären und intertubulären Bindegewebe der Transplantate die Zahl der vom Empfänger stammenden Fibroblasten bzw. fibroblastenartigen Zellen erheblich ist. Mit der Möglichkeit, daß diese Zellen z.T. an der Ausbildung des in chronisch abgestoßenen Transplantaten oft verbreiterten interstitiellen und perivasculären Bindegewebe der Niere beteiligt sind, wird gerechnet. Es wird außerdem darauf hingewiesen, daß an der Organisation von Thromben in Transplantaten Blutzellen des Empfängers teilhaben können, dagegen fanden sich keine Anhaltspunkte dafür, daß in einer Endothelisierung des Transplantates durch den Empfängerorganismus die Ursache der Transplantationsadaptation gesehen werden muß.
    Notes: Summary Fibroblasts and fibroblastoid cells with Barr's nuclear bodies were examined in the perivascular and intertubular tissue of 16 kidney-transplants that were removed between 14 days and one and a half year after transplantation. In some of them the renal function had been good until to the removal of the transplants. The results were as follows: 1. In 7 kidneys of male donors transplanted in female recipients between 9 and 14% of the fibroblasts and fibroblastoid cells in the interstitial tissue of the kidney had Barr's nuclear bodies. 2. When the recipient was male and the donor female 14 to 17% of “fibroblasts” with Barr's nuclear bodies were found. 3. In kidneys of female donors transplanted in female recipients between 15 and 22% “fibroblasts” contained Barr's nuclear bodies. 4. When both recipient and donor were male the percentage of interstitial fibroblastic cells with Barr's nuclear bodies in the above-mentioned was 0.3 to 0.6%. These findings indicate that in the perivascular and intertubular tissue of the transplants a considerable number of fibroblasts and fibroblastoid cells come from the receiver. It is therefore possible that these cells are involved in the formation of the interstitial and perivascular connective tissue that is often increased in lately rejected transplants. It is also shown that blood cells of the recipient are able to participate in the organization of thrombi in transplants, whereas there were no indications that the endothelization of the vessels of the transplant by the recipient is responsible for the adaptation of the transplant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00552679
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  • 4
    Electronic Resource
    Electronic Resource
    Weitere Befunde zur sog. Transplantatadaptation menschlicher Nieren (1970)
    Springer
    Virchows Archiv 349 (1970), S. 170-178 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Untersuchung von Fibroblasten bzw. fibroblastenartigen Zellen mit Barrschen Zellkernkörpern im perivasculären und intertubulären Gewebe von 16 Nierentransplantaten, die 14 Tage bis 1 1/2 Jahre nach der Übertragung zum Teil bei guter Funktion entfernt worden waren, führten zu folgenden Ergebnissen: 1. In 7 männlichen Spendernieren, die auf weibliche Empfänger übertragen worden waren, zeigten 9–14% der Fibroblasten bzw. fibroblastenartigen Zellen im Niereninterstitium Barrsche Zellkernkörper. 2. Bei der Konstellation Empfänger männlich — Spender weiblich schwankte der Prozentsatz von sog. Fibroblasten mit Barrschem Zellkernkörper zwischen 14 und 17%. 3. In weiblichen Spendernieren, die auf weibliche Empfänger transplantiert worden waren, wurden zwischen 15 und 22% „Fibroblasten“ mit Barrschen Zellkernkörpern gezählt. 4. Bei der Konstellation Empfänger und Spender männlich betrug die Zahl der Zellen mit Barrschen Zellkernkörpern in obiger Lokalisation 0,3–0,6%. Aus diesen Befunden wird gefolgert, daß im perivasculären und intertubulären Bindegewebe der Transplantate die Zahl der vom Empfänger stammenden Fibroblasten bzw. fibroblastenartigen Zellen erheblich ist. Mit der Möglichkeit, daß diese Zellen z.T. an der Ausbildung des in chronisch abgestoßenen Transplantaten oft verbreiterten interstitiellen und perivasculären Bindegewebe der Niere beteiligt sind, wird gerechnet. Es wird außerdem darauf hingewiesen, daß an der Organisation von Thromben in Transplantaten Blutzellen des Empfängers teilhaben können, dagegen fanden sich keine Anhaltspunkte dafür, daß in einer Endothelisierung des Transplantates durch den Empfängerorganismus die Ursache der Transplantationsadaptation gesehen werden muß.
    Notes: Summary Fibroblasts and fibroblastoid cells with Barr's nuclear bodies were examined in the perivascular and intertubular tissue of 16 kidney-transplants that were removed between 14 days and one and a half year after transplantation. In some of them the renal function had been good until to the removal of the transplants. The results were as follows: 1. In 7 kidneys of male donors transplanted in female recipients between 9 and 14% of the fibroblasts and fibroblastoid cells in the interstitial tissue of the kidney had Barr's nuclear bodies. 2. When the recipient was male and the donor female 14 to 17% of “fibroblasts” with Barr's nuclear bodies were found. 3. In kidneys of female donors transplanted in female recipients between 15 and 22% “fibroblasts” contained Barr's nuclear bodies. 4. When both recipient and donor were male the percentage of interstitial fibroblastic cells with Barr's nuclear bodies in the above-mentioned was 0.3 to 0.6%. These findings indicate that in the perivascular and intertubular tissue of the transplants a considerable number of fibroblasts and fibroblastoid cells come from the receiver. It is therefore possible that these cells are involved in the formation of the interstitial and perivascular connective tissue that is often increased in lately rejected transplants. It is also shown that blood cells of the recipient are able to participate in the organization of thrombi in transplants, whereas there were no indications that the endothelization of the vessels of the transplant by the recipient is responsible for the adaptation of the transplant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02401774
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  • 5
    Electronic Resource
    Electronic Resource
    Über ein rezidivierendes klarzelliges Leiomyoblastom des Uterus (1976)
    Springer
    Virchows Archiv 371 (1976), S. 243-250 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report on the clinical and pathologic manifestations of an unusual myometrial tumor that developed in a woman now 52 years old. Fifteen years before, she had been operated on for a “leiomyoma” of the uterus. On re-operation 9 years later and again 4 years later a clear cell leiomyoma of the uterus was resected but each time it appeared histologically benign. A third local recurrence of the tumor 7 months later necessitated a fourth operation. The tumor was then found to be invasive, preventing total excision, and histologically was malignant as the striking cellular pleomorphism suggested. As far as we know, only two similar cases have been reported in the literature, but these were diagnosed as benign and followed for only short periods. The discrepancy between the benign histologic picture of this tumor and its biological behavior pose problems in treatment which are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433071
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  • 6
    Electronic Resource
    Electronic Resource
    Relationship between glomerular lesions, serum creatinine and interstitial volume in membrano-proliferative glomerulonephritis (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 603-608 
    Details
    ISSN: 1432-1440
    Keywords: Interstitielle Fibrose ; Niereninsuffizienz ; Glomerulumschäden ; Membranoproliferative Glomerulonephritis ; Interstitial fibrosis ; Renal insufficiency ; Glomerular lesions ; Membranoproliferative GN
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Morphometric investigations in 33 patients suffering from membranoproliferative glomerulonephritis at different grades of glomerular involvement showed that there is no certain relationship between the severity of glomerular lesions and the serum creatinine level. On the other hand there is a significant positive correlation between the relative interstitial volume and the level of serum creatinine. The best congruence (r=+0,87,p〈0.0001) showed an exponential functiony=0.563·e 0.049x . We therefore conclud that in membranoproliferative glomerulonephritis which is generally considered to be a glomerular disease, interstitial changes have to be taken into account as a cause of renal insufficiency. Glomerular lesions alone cannot explain the functional impairment. The pathophysiologic factors concerning increased interstitial volume as a cause of renal insufficiency — probably immunologic in origin — are yet to be completely clarified.
    Notes: Zusammenfassung An 33 Patienten mit membranoproliferativer GN verschiedener Schweregrade konnte gezeigt werden, daß keine sicheren Beziehungen zwischen Ausmaß der glomerulären Veränderungen und dem Serum-Kreatininspiegel bestehen. Andererseits zeigen morphometrische Untersuchungen signifikante positive Korrelationen zwischen dem relativen Interstitiumvolumen und dem Serum-Kreatininspiegel. Der Kurvenverlauf entspricht am ehesten einer Exponentialfunktion (y=0,563·e 0,049x ,r=+0,87,p〈0,0001). Bei der membranoproliferativen GN, die allgemein als rein glomeruläre Erkrankung angesehen wird, müssen auch Veränderungen im Interstitium als eine Ursache der Nierensuffizienz in Betracht gezogen werden. Glomeruläre Schäden allein reichen zur Erklärung der beeinträchtigten Nierenfunktion nicht aus. Der pathophysiologische Mechanismus, der über eine — möglicherweise immunologisch bedingte — Verbreiterung des Niereninterstitiums zur Niereninsuffizienz führt, muß noch geklärt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01490515
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  • 7
    Electronic Resource
    Electronic Resource
    The different forms of glomerulonephritis morphological and clinical aspects, analyzed in 2500 patients (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 59-73 
    Details
    ISSN: 1432-1440
    Keywords: Glomerulonephritiden ; Nephrotisches Syndrom ; Hypertonie ; Glomerulonephritides ; Nephrotic syndrome ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Comparative morphological and clinical studies of 2 500 patients suffering from glomerulonephritis, enabled us to divide the different forms of diffuse glomerulonephritis into 3 distinct groups and to separate these groups from the focal glomerulonephritides. The different forms of diffuse glomerulonephritis in group I are: 1. endocapillary (acute) glomerulonephritis (of the post-streptococcal type), 2. mesangioproliferative glomerulonephritis, 3. mesangioproliferative glomerulonephritis with focal crescents, 4. mesangioproliferative glomerulonephritis with focal scarring, 5. minimal proliferating intercapillary glomerulonephritis without nephrotic syndrome. It is emphasised that these forms can transform into one another, that they seldom occur with nephrotic syndrome, and with varying frequency with hypertension. Group II consists of: 1. minimal proliferating intercapillary glomerulonephritis with nephrotic syndrome, 2. focal sclerosing glomerulonephritis, 3. perimembranous glomerulonephritis, 4. membranoproliferative glomerulonephritis, 5. lobular glomerulonephritis. It is stressed that these glomerulonephritis forms usually do not develop out of group I type glomerulonephritis forms, and that in this group a nephrotic syndrome is the most prominent clinical syndrome. In the third group are 1. mesangioproliferative glomerulonephritis with diffuse crescents, 2. necrotising glomerulonephritis. It is shown that this form of glomerulonephritis does not usually develop from either group I or II forms. The fourth group of focal glomerulonephritis is uncommon. This disease is characterized by a necrotising and proliferative inflammatory lesion found segmentally and focally in the glomeruli. Most of the other glomeruli appearing normal. It is emphasised that in the literature the diagnosis focal glomerulonephritis is made far too often. This is because glomeruli in which the inflammatory process in a few lobules is of varying prominence, are included in the focal glomerulonephritis group. The classification of the different forms of glomerulonephritis into 3 groups here described, is thought of as a basic classification. It is compared with Ellis' classification (1942), with which it has much in common.
    Notes: Zusammenfassung Vergleichende morphologische und klinische Untersuchungen bei 2 500 glomerulonephritiskranken Patienten ergaben, daß die verschiedenen diffusen Glomerulonephritiden in 3 Gruppen eingeteilt werden können und daß von den diffusen Glomerulonephritiden die Herdnephritiden abzugrenzen sind. Zu den diffusen Glomerulonephritiden der Gruppe I werden gerechnet: 1. Die endocapilläre (akute) Glomerulonephritis vom Typ der Poststreptokokken-Glomerulonephritis, 2. die mesangioproliferative Glomerulonephritis, 3. die mesangioproliferative Glomerulonephritis mit fokaler Halbmondbildung, 4. die mesangioproliferative Glomerulonephritis mit fokaler Narbenbildung, 5. die minimal proliferierende intercapilläre Glomerulonephritis ohne nephrotisches Syndrom (minimal changes Läsionen ohne nephrotisches Syndrom nach Habib, 1973). Es wird hervorgehoben, daß diese Glomerulonephritiden ineinander übergehen können, daß sie selten mit nephrotischem Syndrom und unterschiedlich häufig mit Hypertonie einhergehen. Zur Glomerulonephritis Gruppe II werden gezählt: 1. die minimal proliferierende intercapilläre Glomerulonephritis mit nephrotischem Syndrom (sog. minimal changes Läsionen mit nephrotischem Syndrom nach Habib), 2. die fokal sklerosierende Glomerulonephritis (Hyalinose segmentaire et focale von Habib), 3. die perimembranöse Glomerulonephritis, 4. die membranoproliferative Glomerulonephritis, 5. die lobuläre Glomerulonephritis. Es wird betont, daß diese Glomerulonephritiden gewöhnlich nicht aus den Glomerulonephritiden der Gruppe I hervorgehen, ferner, daß bei ihnen ein nephrotisches Syndrom zum führenden klinischen Syndrom gehört. Zu den Glomerulonephritiden der Gruppe III wird die mesangio-proliferative Glomerulonephritis mit diffuser Halbmondbildung und die nekrotisierende Glomerulonephritis gerechnet. Es wird darauf hingewiesen, daß diese Form der Glomerulonephritis gewöhnlich rapid progressiv verläuft. Die vorliegende Klassifikation ist als Basiseinteilung der Glomerulonephritiden gedacht und wird mit der alten Klassifikation von Ellis (1942) verglichen, wobei sich viele Gemeinsamkeiten ergeben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468771
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  • 8
    Electronic Resource
    Electronic Resource
    Übergang einer Glomerulonephritis vom Poststreptokokkentyp in eine rapid-progressive Glomerulonephritis (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 259-264 
    Details
    ISSN: 1432-1440
    Keywords: Poststreptococcal type glomerulonephritis ; Rapidly progressive glomerulonephritis ; Endokapilläre (akute) Glomerulonephritis vom Poststreptokokkentyp ; Rapid-progressive Glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Verlauf einer morphologisch nicht sehr schweren Glomerulonephritis vom Post-streptokokkentyp traten bei einem 37jährigen Patienten nach 4 Monaten Proliferationen der Bowmanschen Kapselepithelien auf. Der klinische Verlauf war im Gegensatz zum normalen gutartigen Verlauf der Glomerulonephritis vom Poststreptokokkentyp rapid-progressiv, die chronische Niereninsuffizienz war bereits 5 Monate nach Krankheitsbeginn im Terminalstadium. Beide Nierenbiopsien, die im Abstand von 4 Monaten entnommen wurden, zeigten immunhistologisch und elektronenmikroskopisch dichtliegende, teilweise konfluierende Immunkomplexablagerungen (humps) auf der glomerulären Basalmembran. Diese dichtliegenden Immunkomplexablagerungen werden bei diesem Patienten als prognostisch ungünstiges Zeichen gewertet.
    Notes: Summary In the morphological course of a poststreptococcal type glomerulonephritis in a 37-year old patient without evidence of streptococcal infection crescents of Bowman's capsule developed after 4 months. The clinical course was rapidly progressive (the patient was uremic 5 months after onset) in contrast to the normal fair prognosis of the poststreptococcal type glomerulonephritis. Two renal biopsies were examined at an intervall of 4 months. Both showed closely packed immunecomplex deposits (humps) on the glomerular basement membrane immuno- and electronmicroscopically. It is suggested that the confluence of glomerular immunecomplex deposits in the poststreptococcal type glomerulonephritis is a prognostically unfavourable sign.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484726
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  • 9
    Electronic Resource
    Electronic Resource
    The morphological and clinical course of the different forms of glomerulonephritis (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 105-116 
    Details
    ISSN: 1432-1440
    Keywords: Glomerulonephritis ; Prognose ; Therapie ; Hypertonie ; akutes Nierenversagen ; Glomerulonephritis ; prognosis ; therapy ; hypertension ; acute renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary From repeat biopsies of 291 patients with glomerulonephritis, the clinical and morphological course of the individual forms of glomerulonephritis were compared with one another. From these results we concluded that: 1. Every form of glomerulonephritis has in all probability its individual course and prognosis, which can only be very slightly influenced by therapy. 2. The prognosis is considerably worsened, when either hypertension develops or tubular lesions in the morphological sense of an acute renal failure.
    Notes: Zusammenfassung Der klinische und morphologische Verlauf der einzelnen Glomerulonephritisformen werden anhand von Mehrfachpunktaten der Nieren von 291 Patienten miteinander verglichen. Dabei ergibt sich folgendes: 1. Jede Glomerulonephritisform hat im Sinne der Wahrscheinlichkeit eine eigene Prognose, die nur wenig durch medikamentöse Therapie beeinflußbar ist. 2. Die Prognose verschlechtert sich erheblich, wenn ein Hypertonus oder tubuläre Läsionen im Sinne eines akuten Nierenversagens hinzutreten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468787
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  • 10
    Electronic Resource
    Electronic Resource
    Membranoproliferative glomerulonephritis with partial lipodystrophy (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 75-81 
    Details
    ISSN: 1432-1440
    Keywords: Membranoproliferative Glomerulonephritis ; Lipodystrophie ; nephritogener Faktor ; C3-Mangel ; Membranoproliferative glomerulonephritis ; Lipodystrophy ; Nephritogenic factor ; C3-deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The course of disease of a patient with membranoproliferative glomerulonephritis and partial lipodystrophy is described. The case is further characterized by a deficiency of C3 and of C3-activator, by normal values of C4, by evidence of the nephritogenic factor, by raised fibrin degradation products and by an unselective proteinuria. The course of the glomerulonephritis runs parallel to a pronounced susceptibility to infection (at first varicella, tonsillitis and measles, later pneumonia, meningitis, encephalitis and hepatitis). On account of a nephrotic syndrome and an initiative impairment of the renal function, a cytostatic treatment was begun, which although raising the C3 level, did not influence the further course of the disease. As the patient has a healthy identical twin sister without lipodystrophy, who shows no reduction in C3 and no nephritogenic factor, this case proves that these diseases are acquired and not genetically determined.
    Notes: Zusammenfassung Bei einer Patientin mit membranoproliferativer Glomerulonephritis und partieller Lipodystrophie konnte ein Mangel an C3 und C3-Aktivator bei normalem C4 nachgewiesen werden, sowie das Vorkommen des nephritogenen Faktors, vermehrte Fibrinspaltprodukte und eine unselektive Proteinurie. Der Verlauf der Glomerulonephritis wird durch eine erhebliche Infektneigung kompliziert (anfangs Windpocken, Tonsillitis, Masern, später Pneumonie, Meningitis, Encephalitis und Hepatitis). Wegen des nephrotischen Syndroms und beginnender Niereninsuffizienz wurde eine Cytostatika-Therapie begonnen, worauf zwar der C3-Gehalt anstieg, der Verlauf der Krankheit jedoch nicht beeinflußt wurde. Da die Patientin eine gesunde eineiige Zwillingsschwester ohne Lipodystrophie hat, die keine Verminderung der C3-Aktivität und keinen nephritogenen Faktor aufweist, beweist der vorliegende Fall, daß diese Krankheiten erworben und nicht genetisch determiniert sind.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468772
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