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  • Polymer and Materials Science  (5)
  • Antithrombin III  (2)
  • CRF  (2)
  • Nuclear reactions  (2)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section A 183 (1972), S. 497-508 
    ISSN: 0375-9474
    Keywords: Nuclear reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section A 184 (1972), S. 599-608 
    ISSN: 0375-9474
    Keywords: Nuclear reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0196-9781
    Keywords: Atropine ; CNS and gut motor function ; CRF ; Colonic motility ; Paraventricular nucleus of the hypothalamus
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1041
    Keywords: Ipsapirone ; CRF ; ACTH ; cortisol ; time series analysis ; hypothalamic-pituitary-adrenal axis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The neuroendocrine effects (changes in plasma CRF, ACTH and cortisol) of single and multiple (t.d.s. for 2 days) doses of ipsapirone (BAY Q 7821) 5 and 10 mg have been investigated in 6 healthy male volunteers. The study followed a balanced complete block, placebo-controlled and double blind design with two baseline phases (pre and post-treatment). Volunteers were investigated on identical days during 5 successive weeks. The results do not show a specific effect of ipsapirone on the hypothalamic-pituitary-adrenal axis when doses in the range of 5–30 mg per day were given.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 145 (1986), S. 500-503 
    ISSN: 1432-1076
    Keywords: Antithrombin III ; Albumin ; Shock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Low antithrombin III (AT III) levels in shock are usually ascribed to disseminated intravascular coagulation (DIC). However, decreased activities of clotting factors and their inhibitors could reflect a generalised fall in plasma proteins rather than DIC. AT III and albumin were compared in 48 asphyxiated and non-asphyxiated newborn rabbits (pH6.70–7.30). Both AT III and albumin were markedly decreased in the sickest animals and there was a direct linear relationship between the two proteins (P〈0.001). Similar results were obtained in ten newborn infants suffering from shock and haemorrhagic diathesis. In all cases AT III and albumin were decreased below the normal range and significantly correlated (P〈0.01). Our findings suggest that AT III is not a useful diagnostic marker of DIC. Further, a similar fall of clottable and non-clottable proteins in shock questions the general assumption that the ensuing coagulopathy is due to intravascular coagulation.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 59 (1981), S. 1349-1351 
    ISSN: 1432-1440
    Keywords: Antithrombin III ; Plasma elimination Half-life ; Consumption coagulopathy ; Antithrombin III ; Plasma-Eliminations-Halbwertszeit ; Verbrauchskoagulopathie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Verlauf einer schweren Gerinnungsstörung bei einem Säugling mit Sepsis und Schock wurden vor und während der Substitutionsbehandlung mit humanem Antithrombin wiederholt die Antithrombin-III Spiegel gemessen. Diese Daten wurden mit Hilfe einer Biexponentialfunktion mathematisch ausgewertet. Die Plasma-Eliminations-Halbwertszeit des Antithrombins betrug 7,5 bzw. 10,5 Stunden. Verglichen mit bekannten Plasma-Halbwertszeiten von radioaktiv markiertem Antithrombin III bei Erwachsenen war die Elimination um den Faktor 5–10 beschleunigt. Die deutlich erniedrigten Antithrombin III Spiegel in diesem Fall konnten also mindestens teilweise auf einen beschleunigten Umsatz des Antithrombins zurückgeführt werden. Die Bestimmung der Plasma-Eliminations-Halbwertszeit von Antithrombin III ist hilfreich bei der Abgenzung einer verminderten Produktion von einem gesteigerten Umsatz im Verlauf einer Koagulopathie. Die Diagnose einer disseminierten intravasalen Gerinnung kann so etwas sicherer gestellt werden. Die Vorteile der Antithrombin- Substitutionstherapie werden bei diesem Vorgehen genützt, die Nachteile radioaktiv markierter Proteine vermieden.
    Notes: Summary During the course of severe coagulopathy in an infant suffering from septicaemia and shock, antithrombin III levels were determined repeatedly before and during substitution therapy with human antithrombin. By mathematical analysis of these data, using a biexponential function, the plasma elimination half-life of the antithrombin III was estimated to be 7.5–10.5 h. Compared with known plasma half-lives of radioactively labelled antithrombin III in adults the increase was five-to ten-fold. This indicates that the significantly decreased levels of antithrombin III in this case of coagulopathy were at least partly due to an accelerated consumption of antithrombin III. The estimation of the plasma elimination half-life of antithrombin III helps to differentiate decreased production from increased consumption in cases of severe coagulopathy. Thus, a more precise diagnosis of disseminated intravascular coagulation can be made whilst taking advantage of substitution therapy and avoiding the hazards of radioactive tracer proteins.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0009-286X
    Keywords: Fischer-Tropsch-Synthese ; Suspensions-Reaktor ; Mn/Fe- und Fe/Cu-Katalysator ; Produktverteilung nach Schulz-Flory ; Geschwindigkeitskonstanten für Synthesegas-Verbrauch ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 24 (1996), S. 511-516 
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Vapor phase decomposition-droplet surface etching-graphite furnace atomic absorption spectroscopy (VPD-DSE-GFAAS) is discussed as a technique for the determination of low levels of metals in chemical oxides on silicon surfaces. The VPD-DSE-GFAAS technique was found to be statistically equivalent to results obtained by the standard surface techniques of total reflectance x-ray fluorescence spectroscopy (TXRF) and SIMS. The capability of the VPD-DSE-GFAAS technique has been extended to detection limits in the 107 to low 109 atom cm-2 range. A positive linear relationship was found for iron, calcium, zinc and aluminum deposited on a silicon wafer from an ammonium hydroxide-hydrogen peroxide-water (SC1) solution. Sodium and potassium deposition from SC1 solutions was found to be independent of solution concentrations. Deposition for these metals appeared to be primarily related to localized micron-sized nuclei deposits and not to adsorption on an atomic scale.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 26 (1998), S. 359-366 
    ISSN: 0142-2421
    Keywords: X-ray technique for structure analysis ; depth profiling ; nanocluster ; self-diffusion in metals ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Results obtained from scanning transmission electron microscopy combined with energy-dispersive X-ray imaging (EDX) and from Rutherford backscattering spectroscopy (RBS) of implanted and multilayered structures are compared in order to demonstrate the depth profiling capabilities of both analysis methods, especially at interfaces. Typical samples for dilute and concentrated systems are compared. The dilute system is represented by Ge nano-clusters in an amorphous SiO2 matrix on a Si substrate produced by ion implantation and subsequent annealing. The concentrated system of alternating Ag-Al multilayers (typical thickness ∽200 nm) is produced by evaporation on Si substrates under high vacuum conditions. A significant advantage of STEM-EDX is the two-dimensional mapping and depth profiling of light and heavier elements in heavy-Z substrates (depth scale in nanometres) without the lack of a deteriorating depth resolution at increasing depth, as happens in RBS. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Acta Polymerica 35 (1984), S. 673-677 
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The properties of 3β-hydroxysteroides were modified by their conversion with polymer carriers and with polymerizable monomers, respectively. The acetalization was carried out under mild reaction conditions. In dependence of the nature of the 3β-hydroxysteroide and the solvent, respectively, acetals with an degree of conversions up t o 15% were obtained. Polymer carriers were prepared by radical polymerization of vinylacetate - crotonaldehyd. Dextranaldehyd was prepared by oxidation of dextran with NaIO4 Polymeric steroidesters were prepared by conversion of Sβ-hydroxy-steroides with methacryloylchloride and subsequent radical copolymerization with methacrylic acid.
    Notes: Zur Eigenschaftsmodifizierung polymerer Pharmaka wurden 3β-Hydroxysteroide mit polymeren Trägern bzw. polymerisierbaren Monomeren umgesetzt. Die Acetalisierung erfolgte unter milden Bedingungen und ergab in Abhängigkeit vom eingesetzten 3β-Hydroxysteroid bzw. vom Lösungsmittel Acetale mit einem Umsetzungsgrad von maximal 15%. Als polymere Träger wurden die auf radikalischem Wege hergestellten Copolymere Vinylacetat/Crotonaldehyd sowie der bei der Oxidation von Dextran mit NaIO4 erhaltene Dextranaldehyd eingesetzt. Polymere Ester wurden durch Umsetzung von 3β-Hydroxysteroiden mit Methacrylsäurechlorid und anschließender radikalischer Copolymerisation mit Methacrylsäure erhalten.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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