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  • 1
    Electronic Resource
    Electronic Resource
    73. Erfahrungen bei der orthotopen Xenotransplantation der Hundeleber auf das Schwein (1971)
    Springer
    Langenbeck's archives of surgery 329 (1971), S. 222-223 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde bei 11 Schweinen eine orthotope Xenotransplantation der Hundeleber durchgeführt. Die Überlebensdauer war durchschnittlich 4,3 ± 1,5 Std. Die Todesursachen waren generalisierte Blutungen. Um die hyperakute Abstoßungsreaktion zu bremsen, wurden vor der Verpflanzung der Hundeleber bei 5 Fällen Hundeniere und Hundemilz je 20 min und bei 5 anderen Fällen eine zweite Hundeleber am Femoralkreislauf eingeschaltet. Wegen der stark aufgetretenen Kreislaufreaktion (Tachykardie und Hypotonie) war die Überlebensdauer noch kürzer. Aus gleichen Gründen wurden hohe Dosen Prednisolon intraund postoperativ bei 5 Fällen verabreicht. Die Überlebensdauer von 4 Schweinen war 9,0 :L 2,2 Std. Ein Schwein überlebte 5 Tage. Bei diesem Schwein wurde Hundeproteinsynthese beobachtet.
    Notes: Summary Orthotopic xeno-transplantations of dog livers into 11 pigs were carried out. The survival time was on average 4.3 ± 1.5 h. The cause of death was generalized haemorrhage. To inhibit the hyperacute rejection, before trans-planting the dog liver we connected dog kidneys and dog spleens in 5 cases and in another 5 cases a second dog liver to the femoral circulation, 20 min, before the transplant, in each case. In view of the very strong circulatory reaction (tachycardia and hypotension) the survival time was even shorter. For the same reason high doses of prednisolone were administered intra- and postoperatively in 5 cases. The survival time of 4 pigs was 9.0 ± 2.2 h. One pig survived for 5 days, and in this animal we were able to observe dog-protein synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01770490
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  • 2
    Electronic Resource
    Electronic Resource
    Der Effekt von hohen Dosen Prednisolon auf die hyperakute Abstoßungsreaktion bei der orthotopen Xenotransplantation der Hundeleber auf das Schwein (1972)
    Springer
    Research in experimental medicine 157 (1972), S. 107-122 
    Details
    ISSN: 1433-8580
    Keywords: Xenograft ; Livertransplantation ; Prednisolon ; Xenotransplantation ; Lebertransplantation ; Prednisolon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Es wurde in 11 Fällen die orthotope Xenotransplantation der Hundeleber auf das Schwein durchgeführt. Die Überlebensdauer betrug 4,3 ± 1,5 Std. Todesursache war eine generalisierte Blutung. 2. Um die hyperakute Abstoßungsreaktion zu bremsen, wurden bei 5 Fällen hohe Dosen Prednisolon verabreicht. Die Überlebensdauer von 4 Empfängern war 9 ± 2,2 Std, 1 Schwein überlebte 5 Tage. Die Bremsung der hyperakuten Abstoßungsreaktion ist durch hohe Dosen Prednisolon teilweise möglich.
    Notes: Summary 1. 11 orthotopic xenotransplantations of canine liver to pig were carried out. The survival time was 4.3 ± 1.5 hrs. The death occured because of general bleeding. 2. To stop the hyperacute rejection high dosage of prednisolon was given intraand postoperativ in 5 cases. 4 recipients survived 9 ± 2.2 hrs and 1 of them 5 days. It is partly possible to stop the hyperacute rejection of xenografts dog-to-pig with high dosage of prednisolon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851692
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  • 3
    Electronic Resource
    Electronic Resource
    Oxalose Typ I im Kindesalter — Beobachtungen im Rahmen der terminalen Niereninsuffizienz beim Kind (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 1156-1167 
    Details
    ISSN: 1432-1440
    Keywords: Hyperoxaluria Type I ; Chronic renal failure ; Kidney and liver transplantation ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The difficulties of biochemical diagnosis in children and in chronic renal failure are discussed in detail, as well as the development of diagnostic and therapeutic possibilities in recent years, exemplified by 4 cases. Excretion of oxalate (and glycolate) may be incorrectly assumed to be normal with: a) uncritical application of the method of measurement, b) disregard of the clearly lower oxalate excretion in children (values should be referred to m2 of body surface), c) disregard of a decreased glomerular filtration rate (values should be referred to the creatinine clearance). With compromised renal function the excretion of oxalate and glycolate in primary oxalosis drops to “normal” whereas plasma values increase considerably. In this case the biochemical diagnosis is possible only by measurement of plasma values of glycolate and oxalate. Consequently, extensive extrarenal deposition of calcium oxalate crystals will, as a rule, become clinically manifest only after chronic renal failure has turned irreversible. In recent years, several therapeutic procedures, have been developed. They are of therapeutic significance for the early stages of the disease as well. Observing especially conditions renal transplantation or combined hepatorenal transplantation can be managed with a successful outcome. As the perioxisomal enzyme is activated only in the liver cells, an early liver transplantation as a definitive treatment by enzyme replacement may be the successful therapy in the future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726118
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  • 4
    Electronic Resource
    Electronic Resource
    Feinstrukturelle Aspekte der Gefäßveränderungen bei Homocystinurie (1971)
    Springer
    Virchows Archiv 354 (1971), S. 44-51 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Homocystinurie ist durch einen ausgesprochenen Mangel des Enzyms Cystathioninsynthetase charakterisiert. Die pathomorphologischen Veränderungen der Gefäßwand werden beschrieben. In der Aorta sind die elastischen Fasern fragmentiert und die glatten Muskelzellen atrophisch und vermindert. In den kleinen Gefäßen und Arteriolen können grundsätzlich dieselben Veränderungen nachgewiesen werden. Außerdem werden amorphe Substanzen in dem erweiterten Intercellularraum beschrieben. Diese Veränderungen werden als Folge einer gestörten Stoffwechselleistung der glatten Muskelzellen aufgefaßt.
    Notes: Summary Homocystinuria is characterized by a pronounced deficiency of the enzyme cystathionine synthetase. The pathomorphological alterations of the vessel wall are described. In the aorta the elastic fibers are fragmented and the smooth muscle cells are atrophic and decreased in number. Basically, the same alterations can be demonstrated in small vessels and arterioles. Furthermore, amorphous substances can be observed in intercellular spaces. These pathomorphological alterations seem to be the result of the disturbed metabolic function of smooth muscle cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544106
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  • 5
    Electronic Resource
    Electronic Resource
    Feinstrukturelle Aspekte der membranösen Glomerulonephritis bei nephrotischem Syndrom (1971)
    Springer
    Virchows Archiv 353 (1971), S. 248-260 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 52 Nierenpunktate von Erwachsenen aus Deutschland und Japan wurden elektronenmikroskopisch untersucht. Während bei frischen Fällen charakteristische elektronendichte Ablagerungen im Epimembraneum nachgewiesen werden, sind diese Ablagerungen bei länger verlaufender Erkrankung in der epithelialen Seite der unregelmäßig verdickten Basalmembran lokalisiert. Die älteren Ablagerungen sind von geringerer Elektronendichte. Zwischen diesen Ablagerungen und den Podocyten liegt eine neu gebildete Basalmembran. Die Häufigkeit der membranösen Glomerulonephritis bei nephrotischem Syndrom ist in unserem Untersuchungsgut geringer als allgemein angenommen. Unterschiede zwischen deutschen und japanischen Patienten sind qualitativ und quantitativ nicht feststellbar. Der Mischtyp der membranösen proliferativen Glomerulonephritis und sein klinisches und feinstrukturelles Verhalten wird diskutiert.
    Notes: Summary The electron microscopic findings in membranous glomerulonephritis from 27 German and 25 Japanese adult patients with nephrotic syndrome have been described. At the beginning of the disease massive deposits were seen in the epimembraneum of the capillary loops. In chronic cases these deposits were found at the epithelial side of the basement membrane, which also showed marked but irregular thickening. The older deposits become less electron dense or even translucent while new basement membrane was synthetized between the deposits and the podocytes. No qualitative relationship was found to exist between the thickening of the basement membrane due to the deposition of dense materials and clinical data of the patients. The frequency of membranous glomerulonephritis in nephrotic syndrome was less than had been expected. There were no differences qualitatively and quantitatively between German and Japanese cases. The mixed type of membranous and proliferative glomerulonephritis and its clinicopathological behaviour are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00545733
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  • 6
    Electronic Resource
    Electronic Resource
    Feinstrukturelle Aspekte der menschlichen Glomerulonephritis (1971)
    Springer
    Virchows Archiv 353 (1971), S. 157-168 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 42 Nierenbiopsien von Kindern mit persistierender (postakute Form nach Bohle, 1964) und chronischer proliferativer Glomerulonephritis wurden elektronenmikroskopisch untersucht. Obwohl die Glomerulonephritis bei Kindern im Vergleich zu Erwachsenen einen abgeschwächten Verlauf hat, zeigen sich dennoch dieselben charakteristischen morphologischen Veränderungen. Die persistierende (postakute) proliferative Glomerulonephritis ist pathomorphologisch durch elektronendichte Ablagerungen im Mesangium und in den Basalmembranen der Capillarschlingen charakterisiert. Häufig ist dieses Krankheitsbild mit einem nephrotischen Syndrom verbunden. Zwischen idiopathischer Nephrose und nephrotischer Glomerulonephritis können keine morphologischen Unterschiede festgestellt werden. Die Basalmembranverdickung der Capillarschlingen ist bei bestehender Nephrose abhängig von der Dauer der Albuminurie. Quantitativ sind die Ablagerungen im Mesangium oder in den Basalmembranen der Capillarschlingen geringer ausgeprägt als bei Erwachsenen.
    Notes: Summary Using electronmicroscopic techniques, 42 kidney biopsies from children suffering with persistent (“postakute Form”, Bohle, 1964) and chronic proliferative glomerulonephritis were studied. Although glomerulonephritis in children has a milder course compared with adults, the same morphological alterations were found. The persistent (“postakute Form”, Bohle, 1964) proliferative glomerulonephritis is pathomorphologically characterized by electron dense deposits in the mesangium and capillary basement membranes. There was no morphological difference between idiopathic nephrosis and nephrotic glomerulonephritis. The thickening of the capillary basement membranes in nephrosis depends on the duration of albuminuria. The deposits in mesangium or in capillary basement membranes are less severe than in adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548974
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  • 7
    Electronic Resource
    Electronic Resource
    Age-dependent increase in arterial smooth muscle calcium in spontaneously hypertensive rats (1988)
    Springer
    Research in experimental medicine 188 (1988), S. 397-403 
    Details
    ISSN: 1433-8580
    Keywords: Ca2+ ; Arterial smooth muscle ; Spontaneously hypertensive rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Alterations in cellular calcium metabolism in essential hypertensive and in the SHR have been described. In the present study, particle-induced X-ray emission (PIXE) was used to get some information on the spatial distribution of Ca2+ in aortas of spontaneously hypertensive rats (SHR) and normotensive controls aged 1 week, 4 weeks, and 12 weeks. It was found that the Ca2+ content was not elevated in the aortic smooth muscle of SHR aged 1 week (n = 9) as compared to normotensive controls (n = 8) (186.8 ± 89.9 µg Ca2+/g tissue vs 254.0 ± 73.7 µg Ca2+/g tissue. The Ca2+ content was significantly raised in the aortic smooth muscle of SHR aged 4 weeks (n = 9) as compared to 4-weeks-old WKY rats (n = 12) (726.0 ± 130.4 Ca2+/g tissue vs 440.3 ± 214.4 Ca2+ µg/g tissue and in SHR aged 3 months (n = 15) as compared to WKY rats (n = 12), respectively (3317.0 ± 734.0 µg Ca2+/g tissue vs. 1632.0 ± 569.6 µg Ca2+/g tissue). The results confirm the age-related increase in the arterial Ca2+ content in normotensive rats and demonstrate additionally that this age-related rise in arterial Ca2+ content is accelerated in SHR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851997
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  • 8
    Electronic Resource
    Electronic Resource
    Klinische, pathologische und biochemische Untersuchungen in einem Fall von infantiler generalisierter Gangliosidose (GM1-Mucolipidose) (1972)
    Springer
    European journal of pediatrics 112 (1972), S. 23-42 
    Details
    ISSN: 1432-1076
    Keywords: Gangliosidosis ; Absence of β-galactosidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Schilderung eines Falles von infantiler generalisierter Gangliosidose infolge Fehlens der β-Galaktosidase. Dabei werden das Gangliosid GM1 und ein Keratan-ähnliches Mucopolysaccharid in Ganglienzellen, Leber, Milz, Niere und Knochenmark gespeichert. Die Eltern des Kindes sind blutsverwandt. Bei einem unter der Geburt verstorbenen Geschwisterkind konnten zwar die gleichen morphologischen Speicherphänomene, nicht jedoch der Enzymdefekt nachgewiesen werden. Auffällig ist die Steigerung der Aktivität der β-N-Acetyl-Hexosaminidase bei dem Geschwisterkind und in Fibroblasten der Eltern.
    Notes: Abstract Report on a case of infantile generalized gangliosidosis due to deficiency of β-galactosidase. There is accumulation of ganglioside GM1 and a Keratanlike mucopolysaccharide in the brain and viscera. The parents are consanguineous. In a sibling who died during delivery the same morphological phenomena of storage were found but no enzyme deficiency. The activity of β-N-acetyl-hexosaminidase was elevated in the sibling and in fibroblasts of both parents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00491963
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructure of heart muscle in generalized gangliosidosis GM1 (1971)
    Springer
    European journal of pediatrics 110 (1971), S. 104-114 
    Details
    ISSN: 1432-1076
    Keywords: Inborn Errors of Metabolism ; Generalized Gangliosidosis GM1 ; Ultrastructure of Heart Muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die generalisierte Gangliosidose GM1 ist durch einen erheblichen bzw. vollständigen Mangel des Enzyms β-Galactosidase gekennzeichnet. Die Spaltung der endständigen Galactosemoleküle vom Gangliosid GM1 ist deshalb blockiert. Es werden die Veränderungen der Herzmuskelzellen, der Capillarendothelien und der vegetativen Nervenfasern beschrieben. Große Vacuolen mit einem feinflockigen Inhalt und Einschlußkörper stellen die wesentlichen Befunde dar.
    Notes: Abstract Generalized gangliosidosis GM1 is characterized by the almost complete deficiency of the enzyme β-galactosidase, therefore the cleavage of the terminal galactose from the gangliosid GM1 is impaired. Typical alterations could be observed in generalized gangliosidosis GM1 in heart muscle cells as well as in capillary endothelium, and nerve fibers. Large vacuoles, containing granular or flocculent material and inclusion bodies, were obvious.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442285
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  • 10
    Electronic Resource
    Electronic Resource
    Thromboembolisehe Komplikationen und Thrombocytenanomalien bei Homocystinurie (1972)
    Springer
    European journal of pediatrics 112 (1972), S. 309-320 
    Details
    ISSN: 1432-1076
    Keywords: Homocystinuria ; Thromboembolism ; Platelets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der vorliegenden Arbeit wird über 7 Patienten mit Homocystinurie berichtet. Bei 4 von ihnen traten thromboembolische Komplikationen auf, die zweimal Todesursache waren. Autoptisch konnten in diesen beiden Fällen Sinus- und Gehirnvenenthrombosen sowie Hirnerweichungsherde nachgewiesen werden. Bei 6 Patienten mit Homocystinurie wurden die Thrombocyten isoliert und elektronenoptisch untersucht. Als konstanter befund zeigte sich eine erhebliche Vacuolisierung im Cytoplasma der Thrombocyten. Diese Veränderung werden als Hinweis für die thrombocytogene Natur, der Gerinnungsstörung bei Homocystinurie angesehen.
    Notes: Abstract 7 patients with homocystinuria are reported. In 4 of them thromboembolic complications occurred, resulting in death of 2 patients. The postmortem examination in both of these cases showed thromboses of sinus and cerebral veins as well as encephalomalacic lesions. In 6 patients with homocystinuria platelets were isolated and investigated by electron microscopy. A constant finding was a distinct vacuolization of the platelet cytoplasm. These changes were regarded as an indication of the thrombocytogenic nature of the coagulation disorder in homocystinuria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00438625
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