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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 46 (1968), S. 906-912 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 1. Following incubation of labeled cortisol and plasma the percentages of protein bound and socalled free endogenous cortisol were determined by means of dextran gel filtration. 2. The diagnostic value of this method was compared with fluorimetric determinations of 11-OHCS for patients with adrenal insufficiency, Cushing-Syndrome, pituitary tumors and after hypophysectomy. In hypophysectomized patients the simple determination of protein bound cortisol was found to correlate well with diagnostic ACTH-infusion tests and to be more sensitive than fluorimetric determinations of 11-OHCS in 9 a.m. plasma. 3. Falsely elevated fluorimetric values of plasma 11-OHCS in patients treated with spirolactone or estrogens, resp. during pregnancy may be recognized through determination of cortisol binding. — In thyrotoxicosis socalled free cortisol was elevated, both relatively and absolutely; in hypothyroidism an increase of protein bound cortisol was found.
    Notes: Zusammenfassung 1. Mittels Dextrangelfiltration wurde nach Inkubation von markiertem Cortisol und Plasma der proteingebundene und der sog. freie Anteil (%) des endogenen Plasmacortisols ermittelt und bei gleichzeitiger fluorimetrischer Bestimmung der 11-OHCS auch die Menge proteingebundenen, bzw. sog. freien Cortisols (µg-%) berechnet. 2. Die diagnostische Brauchbarkeit der Methode wurde bei Patienten mit Nebennierenrindeninsuffizienz, mit Hypophysentumoren, nach Hypophysektomie, mit Cushing-Syndrom mit der fluorimetrischen Bestimmung der 11-OHCS verglichen. Die einfache Bestimmung der Cortisolbindung war bei hypophysektomierten Patienten der Bestimmung der 11-OHCS überlegen und entsprach der aufwendigeren ACTH-Belastung. 3. Falsch hohe fluorimetrische 11-OHCS-Spiegel im Plasma unter Spirolacton- oder Oestrogenbehandlung und in der Gravidität lassen sich durch Bestimmung der Cortisolbindung klären. Bei Schilddrüsenüberfunktion war das sog. freie Cortisol im Plasma relativ und absolut vermehrt, bei Schilddrüsenunterfunktion fand sich eine Zunahme des plasmaproteingebundenen Cortisols.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 4 (1956), S. 344-354 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The AA. report on 4 cases of extradural arterial aneurysm of the internal carotid artery with intrasellar extension. The characteristical development of this clinical picture is described: its neurologic symptomatology with roentgenologic and arteriographic modifications is discussed and a differential diagnosis is made in regard to other processes in the pituitary region.
    Abstract: Résumé On rapporte 4 cas d'anévrismes intrasellaires extra-duraux de l'artère carotide interne. On décrit le développement caractéristique de ce tableau clinique, sa symptomatologie neurologique avec les modifications radiographiques et artériographiques, et l'on fait un diagnostic différenciel avec les autres processus de la région sellaire.
    Notes: Zusammenfassung Bericht über 4 Fälle von intrasellär entwickelten extraduralliegenden arteriellen Aneurysmen der A. car. int. Die charakteristische Entwicklung dieser Krankheitsbilder, ihre neurologische Symptomatik mit röntgenologischen und arteriographischen Veränderungen wurden beschrieben und gegen andere sellanahen Prozesse differentialdiagnostisch abgegrenzt.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 11 (1964), S. 716-730 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary It may be shown that among the pituitary adenomata the so-called “mixed” adenoma was especially inclined to recurrence. Ninety per cent of the recurrent tumours which we have observed were mixed adenomata. The recurrence usually develops within 5 years after the treatment. The eye symptoms, as well as the radiological evidence of an expanding lesion in the region of the sella, are as important for detecting the onset of the recurrence as they were for diagnosis before the first operation. Anterior pituitary insufficiency is more frequent with the recurrent lesions. Because the onset of A. C. T. H. insufficiency is manifested relatively late, the eye signs assume a critical importance in the early diagnosis of recurrences. In this respect, the most useful information is to be derived from the Perimeter. In order to avoid recurrences, intensive postoperative radiation of the mixed adenomata should be requested as part of the initial therapy.
    Abstract: Résumé Il peut être démontré que pour les adénomes hypophysaires l'adénome dit ≪mixte≫ est particuliérement enclin á récidiver. Quatre-vingt-dix pour cent des tumeurs récidivantes que nous avons observées étaient des adénomes mixtes. La récidive habituelle se développe moins de 5 ans aprés le traitement. Les symptômes oculaires, de même que les preuves radiologiques d'une lésion expansive de la région de la selle, sont aussi importants pour détecter la récidive qu'ils l'étaient pour le diagnostic avant la premiére intervention. L'insuffisance pituitaire antérieure est plus fréquente lors des récidives. Parce que l'insuffisance en A. C. T. H. se manifeste relativement tard, les signes oculaires prennent une importance critique dans le diagnostic précoce des récidives. A cet égard, la plus utile information proviendra du champ visuel. Dans le but d'éviter les récidives, une irradiation postopératoire intensive des adénomes mixtes doit être demandée comme un élément de la thérapeutique initiale.
    Notes: Zusammenfassung Es konnte gezeigt werden, daß unter den Hypophysengeschwülsten das sogenannte Mischtypadenom besonders zur Rezidivierung neigt. Zirka 90% der von uns beobachteten Rezidivtumoren waren mischzellige Adenome. Das Rezidiv trat vorwiegend innerhalb von 5 Jahren nach dem Eingriff auf. Die Augensymptome sowie die röntgenologisch faßbaren Veränderungen im Sellabereich waren zum Zeitpunkt des Rezidivs wesentlich ausgeprägter als vor der Erstoperation, und es bestand mit überwiegender Häufigkeit eine Hypophysen-Vorderlappeninsuffizienz. Da sich der Ausfall der corticotropen Vorderlappenfunktion erst relativ spät manifestiert, kommt für die Frühdiagnose des Rezidivtumors den Augenbefunden, insbesondere der Funktionsprüfung, die entscheidende Bedeutung zu. Die wertvollsten Hinweise gibt hierbei die Untersuchung am Perimeter. Zur Verhütung des Rezidivs muß beim Mischtypadenom eine intensive Nachbestrahlung im Anschluß an die Erstoperation gefordert werden.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 13 (1965), S. 138-144 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 47 neurosurgical patients with brain tumours have been studied. Twenty of them were not specifically treated for brain oedema before the operation and are being regarded as controls. In the other 27 patients aldosterone was given pre- and postoperatively for several days in a dose of 2×5 mg per day. During the operation, tissue samples from the vicinity of the tumour, including cortex and white matter, were removed and subjected to analysis of the following: water content, electrolytes (Na, K) and labile metabolites (CP, ATP, ADP, AMP, Pyr., Lact.). When comparing the two groups, a reduction of water content was found in the aldosterone group with a statistical significance at p 0.005. Na was at lower values in both brain compartments in the treated group, whereas K was found to be slightly elevated above the level of the controls. Metabolites showed only minor changes when the 2 groups were compared. From the clinical point of view, patients responded favourably to aldosterone therapy. In no case did treatment with aldosterone result in untoward side effects.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 5 (1957), S. 38-45 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The AA. report on the spontaneous recovery of a carotid aneurysm that was evidenced by angiography. Worth mentioning were the precocious manifestations of the first subarachnoid hemorrhages, already in adolescence, and the complete thrombosis of the relatively scanty aneurysmal sac. The AA. discuss the hemodynamic particularities in the formation of thrombus.
    Abstract: Résumé Les auteurs réfèrent le cas d'une guérison spontanée d'un anévrysme de la carotide, guérison qui fut documentée au moyen de l'angiographie. Dès l'adolescence, la manifestation précoce de la première hémorragie sub-arachnoïdienne et la complète thrombose du sac anévrismal relativement exigu, étaient dignes de remarque. Il est discuté des particularités hémodynamiques dans la formation de l'obstruction thrombotique.
    Notes: Zusammenfassung Es wird über die Spontanheilung eines intracerebralen Carotisaneurysmas berichtet, die angiographisch nachgewiesen werden konnte. Bemerkenswert waren das frühzeitige Auftreten der ersten Subarachnoidalblutung schon in der Adoleszenz und völlige Thrombosierung des relativ kleinen Aneurysmasackes. Auf hämodynamische Besonderheiten beim Zustandekommen eines thrombotischen Verschlusses wird hingewiesen.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 9 (1960), S. 152-156 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 35 (1974), S. 241-254 
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two of the main biochemical features characteristic for oncogenic RNA (oncorna) viruses have been detected in human glioblastoma. In all tumors tested so far a RNA instructed DNA polymerase (“reverse transcriptase”) activity was present which exhibited the criteria specific for oncorna viruses. It was stimulable by the synthetic polynucleotide poly-rA: oligo-dT, it was almost insensitive to actinomycin D but very sensitive to ethidiumbromide. Using the simultaneous detection test, a high molecular weight RNA species was found in the subcellular fraction with the highest reverse transcriptase activity. As revealed by electron microscopy, this subcellular fraction contains particles of a morphology similar to oncogenic RNA viruses of the C-type.
    Type of Medium: Electronic Resource
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