Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    The marine bacterium Alteromonas espejiana induces metamorphosis of the hydroid Hydractinia echinata (1993)
    Springer
    Marine biology 115 (1993), S. 173-178 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The marine hydroid Hydractinia echinata develops into a primary polyp from a planula larva stage. The planula does not undergo metamorphosis in sterile filtered seawater. Metamorphosis is induced by certain bacteria occurring, as a rule, on the shells of molluscs inhabited by hermit crabs of the genus Eupagurus. Bacteria were isolated from shells occupied by H. echinata, and bacterial clones were selected which had a strong potency for inducing metamorphosis in planula larvae. One such clone was further subcloned for strong metamorphosis-inducing potency and finally investigated for inductive characteristics and for identification purposes. The bacterium is a motile, aerogen, gram-negative rod with a polar flagellum. It was identified on the basis of several physiological characteristics as a strain of the genus Alteromonas espejiana. The ability to induce metamorphosis might not be restricted to A. espejiana. The inhibitor of protein kinase C, sphingosine, inhibited metamorphosis induced by A. espejiana. The metamorphosis-inducing principle is likely to be a lipid, since upon lipid extraction and separation of different lipid classes by solid phase extraction on silica-aminopropyl columns a metamorphosis-inducing fraction was obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346332
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Localization of the bronchodilator effect induced by type A natriuretic peptide in asthmatic subjects (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 772-774 
    Details
    ISSN: 1432-1440
    Keywords: Type A natriuretic peptide (CDD/ ANP-99-126) ; Bronchodilation ; Asthma therapy ; Lung function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Type A natriuretic peptide (CDD/ANP99-126) in its circulating form was analyzed with respect to the localization of its bronchodilating effects in asthmatic subjects in vivo. The intravenous infusion of 5.7, 11.4, and 17.1 pmol kg−1 min− CDD/ANP-99-126 caused a significant bronchodilation of both central and peripheral airways. While the localization of the bronchodilating effects was similar to β2-agonists, an improvement in lung function parameters comparable to these substances was not observed. But other members of the natriuretic peptide family may reveal a stronger bronchodilating potency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180545
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and metabolism of cyclophosphamide administered after total body irradiation of bone marrow transplant recipients (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 521-523 
    Details
    ISSN: 1432-1041
    Keywords: Cyclophosphamide ; Pharmacokinetics ; 4-Hydroxycyclophosphamide ; Bone marrow Transplantation ; Total body irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary High-dose cyclophosphamide is used immediately after total body irradiation (TBI) in conditioning for bone marrow transplantation (BMT). Possible interactions of the two treatment modalities were sought by measuring the blood pharmacokinetics of CP and 4-hydroxy-cyclophosphamide (4-HOCP) in patients undergoing BMT. There was a non-significant trend to a shorter half-life of CP compared to reported values. Exposure to 4-HOCP, the major metabolite of CP, did not appear to be altered by prior TBI of the patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315233
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Homogeneous cylindrical plasma source for short-wavelength laser experiments (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 58 (1991), S. 2619-2621 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A plasma source suitable for repetitive operation, going beyond single shot experiments for research into soft x-ray lasers, is reported. Successful operation of an ultrafast, small-diameter, highly uniform z pinch has been achieved at currents of 35–50 kA, for a variety of gases and a large range of mass densities. Due to an efficient preionization of the working gas, a high-temperature and a high cooling rate of the plasma column are obtained. The plasma is less than 1 mm in radius, over 30 mm long, and over 1018 cm−3 ion density. A soft x-ray recombination laser experiment for the λ≈182 A(ring) Balmer-alpha-like transition in C vi is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.104812
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Molecular-resolution images of Langmuir–Blodgett films using atomic force microscopy (1991)
    [s.l.] : Nature Publishing Group
    Nature 349 (1991), S. 398-400 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The study of the ordered molecular structure of LB films was one of the first applications of the scanning tunnelling microscope (STM) to organic materials4'6. There has been some controversy over the interpretation of the images recorded on these rather thick films (-50 A) because classical ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/349398a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Identification of UAS elements and binding proteins necessary for derepression of Saccharomyces cerevisiae fructose-1,6-bisphosphatase (1992)
    Springer
    Current genetics 22 (1992), S. 363-370 
    Details
    ISSN: 1432-0983
    Keywords: Saccharomyces cerevisiae ; Fructose-1,6-bisphosphatase ; Glucose repression ; Gene activation ; Gluconeogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Fructose-1,6-bisphosphatase is a key enzyme in gluconeogenesis and the FBP1 gene is not transcribed during growth with glucose. Genetic analysis indicated a positive regulation of FBP1 expression after exhaustion of glucose. By linker-deletion analysis, two upstream activation sites (UAS1 and UAS2) were localized and the respective UAS-binding factors (DAP I and DAP II for derepression activating protein) were identified by gel retardation. UAS1 and UAS2 span about 30 bp each, and are separated by approximately 30 bp. Both UAS sites act synergistically. Although UAS1 showed some similarities to the DNA-binding consensus for the general yeast activator Rap1, competition experiments and DEAE-chromatography proved that DAP I and Rap1 correspond to different proteins. Gel retardation by DAP I depended on carbon sources and did not occur in cells growing logarithmically with glucose, whereas a strong retardation signal was obtained with ethanol-grown cells. The present results suggest that DAP I and DAP II are the final regulatory elements for glucose derepression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00352437
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Intraosseous leiomyoma of the neck of the femur (1994)
    Springer
    International orthopaedics 18 (1994), S. 47-49 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le léïomyome bénin intra-osseux est une manifestation rare de la léïomyomatose disséminée. Nous présentons le cas d'une femme âgée de 54 ans, qui avait des douleurs de la hanche gauche dues à une lésion kystique du col du fémur. Après résection, l'examen histologique de la pièce a montré un léïomyome bénin intra-osseux. Quelques années auparavant on avait déjà constaté une léïomyomatose péritonéale disséminée.
    Notes: Summary Intraosseous benign leiomyoma is a rare manifestation of disseminated leiomyomatosis. In a 54 year old housewife presenting with a painful left hip due to a cystic lesion of the femoral neck, histological assessment following resection of the cyst showed a benign intraosseous leiomyoma. Years before a diagnosis of disseminated peritoneal leiomyomatosis had been made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180179
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Metabolism and pharmacokinetics of oral and intravenous ifosfamide (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. S148 
    Details
    ISSN: 1432-1335
    Keywords: Ifosfamide ; Activated ifosfamide ; Chloroacetaldehyde ; Metabolism ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The initial metabolism of ifosfamide (IF) consists of two different pathways: enzymatic hydroxylation at carbon-4 forms the cytostatically active metabolite 4-OH-IF (“activated ifosfamide”) whereas side-chain oxidation results in the liberation of chloroacetaldehyde, a compound with possible neurotoxic properties. The pharmacokinetics of ifosfamide and its activated form were investigated in 12 cancer patients, who received both oral and i.v. treatment in a randomized sequence on days 1 and 3 at a dose of 1 g/m2 (n=7) or 1.5 g/m2 (n=5). In 3 patients the pharmacokinetics of chloroacetaldehyde were also investigated. After oral application, ifosfamide absorption proceeded rapidly, the oral bioavailability was 0.92. Independent of the route of ifosfamide application on day 1, the terminal half-life on day 3 (when the drug was given by the alternative route) was decreased in 6 out of the 12 patients, thus indicating self-induction of hepatic metabolism. 4-OH-IF was already present 20 min after ifosfamide administration. In the individual patient the concentrations of 4-OH-IF were always higher after oral than after i.v. IF application: the mean p.o.:i.v. ratios forc max and the area under the concentration/time curve were 2.3 and 1.7 respectively (P〈0.05). In a first series of 3 patients the chloroacetaldehyde concentrations measured after oral ifosfamide application were about twice as high as those when the drug was given intravenously. These results indicate that (in comparison to the i.v. route) orally administered ifosfamide may be more cancerotoxic but also leads to higher levels of chloroacetaldehyde. This would explain the neurotoxic sideeffects previously seen after oral administration of comparatively low ifosfamide doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01613221
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Pressure and temperature dependence of the electric field gradient (EFG) in CdS (1992)
    Springer
    The European physical journal 87 (1992), S. 61-63 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using the time differential perturbed angular correlation technique (TDPAC), the electric hyperfine interaction of111Cd in the II-VI-semiconductor CdS was investigated. The results of the temperature and pressure dependence of the electric field gradient (EFG) are discussed. The binding energyE b for111In at a Cd lattice site and a Cd vacancy (111InCd−VCd−pair) could be estimated to 340 meV±80 meV by means of an Arrhenius-Plot. The disappearance of the 79 MHz and 73 MHz frequencies under a pressure of about 30 kbar could be due to their vacancy character or to the beginning of the phase transition to rocksalt structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01308257
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Studies on the thyroid in transgenic mice expressing the genes for human and bovine growth hormone (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 1043-1046 
    Details
    ISSN: 1420-9071
    Keywords: Thyroid ; transgenic mouse ; human growth hormone ; thyroid hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The thyroid glands of transgenic mice (TM) expressing the genes for human (h) and bovine (b) growth hormone (GH) were studied. The percentages of larger follicles inhGH TM of either sex were significantly greater than in the corresponding normal littermates, and follicles ranging up to 350 μm in diameter were present in malehGH TM. In contrast, thyroid follicles were only slightly enlarged in malebGH TM, and were unchanged in femalebGH TM. The serum concentrations of T4 were significantly decreased in malebGH TM and not altered in the other groups. Serum concentrations of T3 were slightly, but significantly increased in femalehGH TM and femalebGH TM, but were unaffected in male TM of either type. Since the principal difference between these foreign GHs in rodents is the additional lactogenic activity of human GH, these results may indicate that the effects of prolactin can influence the development of the thyroid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940668
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...