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  • 1
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 51 (1982), S. 197-220 
    ISSN: 1432-0738
    Keywords: Acute toxicity ; LD50 method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 170 acute toxicity determinations, carried out in rats, mice, and guinea pigs after oral and parenteral administration during the past 5 years, using 5 ♂/5 ♀ animals per dose, were evaluated with respect to the possibility of a reduction of animals necessary for obtaining LD50 values with limits of confidence. Calculations were performed on existing data; no additional animal experiments were initiated for the purpose of this paper. For the majority of substances 3 ♂/3 ♀ animals per dose would have sufficed for the determination of a LD50 value with limits of confidence. Even when using 2 ♂/2 ♀ animals per dose, in most cases sufficently acceptable LD50 values can be determined, if the period of observation — conventionally 4 weeks — would be doubled. Using this procedure, 75% of the animals could be saved. The reduced number of animals and the labor saved thereby would allow for a more individualized observation of single animals thus optimizing the evaluation of acute toxicity testing.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 287-288 (Aug. 1998), p. 185-188 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of applied ichthyology 14 (1998), S. 0 
    ISSN: 1439-0426
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: RAPD (random amplified polymorphic DNA), RAMPO (random amplified microsatellite polymorphism), SCAR (sequence-characterized amplified regions), microsatellite markers and heteroduplex analysis were applied to differentiate bream (Abramis brama L.) populations from the rivers Main and Danube. Three molecular genetic markers were established; the frequencies of these markers and already established markers were estimated in three bream populations from the Danube River and two bream populations from the Main River. The results showed variation among populations from different river systems as well as variation among samples from the same river basin.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of applied ichthyology 12 (1996), S. 0 
    ISSN: 1439-0426
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A G/T substitution has been found in a 462 bp fragment produced by random PCR amplification (RAPD) of genomic DNA in bleak (Alburnus alburnus). Two bleak populations from the rivers Main and Danube were screened for the two variants by allele-specific PCR. The allele frequencies were 0.62 and 0.31 for variant T, and 0.38 and 0.69 for variant G in the river populations of Main and Danube, respectively. Allele frequencies differed significantly (P 〈 0.01).
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 48 (1996), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Comparison of nucleotide sequences of the growth hormone gene of two populations of bleak from the Main Donau Rivers, Southern Germany, revealed an A/T point mutation resulting in an AluI restriction fragment length polymorphism. The frequencies of alleles T and A are 0–95/0–05 in the Donau and 0–62/0–38 in the Main.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The self-aligned in-line technique has been applied to the preparation of ultrasmall low-capacitance metallic tunnel junctions. By using e-beam lithography the area of Al/AlOx/Al contacts has so far been reduced to less than 0.005 μm2. At low temperatures high-ohmic double junctions with a small metallic island between them show the Coulomb blockade effect. The current through such a device could be modulated by a voltage applied to a gate electrode capacitively coupled to the island (single-electron transistor). Both single-charge phenomena have been observed at temperatures up to 1 K. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have observed intrinsic Josephson effects for current flow perpendicular to the CuO2 planes in HTSC thin films. Tl-Ba-Ca-Cu-O thin films were deposited on step edges in LaAlO3 substrates. Due to the special preparation process, microbridges across such steps act as stacks of intrinsic Josephson junctions with current flow perpendicular to the CuO2 planes (STEP STACK junctions). Up to 130 individual junctions could be observed exhibiting high IcRN products up to 26 mV per junction. We observed ac-Josephson effects as Shapiro steps and in microwave emission experiments. At low temperatures sharp emission peaks were detected at frequencies of 11.3 and 24.2 GHz. Broad emission peaks from the whole stack were observed at temperatures close to Tc. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Mineralogy and petrology 27 (1980), S. 233-260 
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Summary The extensive siderite mineralization of the Hüttenberg deposit is restricted to marble series of the “Saualm Crystalline”. The Ordovician to Devonian age of this metamorphic complex and its Variscan structure is well substantiated. Large-scale tectonic investigations show that the main directions of the B-axes of all types of rocks occurring within the deposit have the same directions. This is also confirmed by investigations of the grain texture: B- as well as S-tectonite orientation can be found. The macroscopically visibles is also attributed to this strong Variscan folding as (h0l)-plane. The axial directions which can be inferred from this orientation coincide exactly with the Variscan large-scale and small-scale folds. Influence of a pre-Variscan or Alpidic phase can also be observed. There is also a distinct orientation of growth fabric. No clear conclusions could be drawn, however, as to their origin. The detection of metasomatic processes neither gives any information as to the process of enrichment nor does it mean that the entire content of the deposit has been added by metasomatic exchange of matter. It is concluded that a mobilization of already existing iron has taken place during the Variscan orogenesis. Such depositional processes could be released to a minor extent only by the fracture tectonics of the Alpidic orogenesis. Thus, quantitative evidence is provided for the first time to show that this “metasomatic” deposit has, in fact, been derived from pre-metamorphic sedimentary iron concentrations.
    Notes: Zusammenfassung Die mächtigen Sideritvererzungen der Lagerstätte Hüttenberg sind auf Marmorzüge des Saualmkristallins beschränkt, dessen ordovizisch-silurisch-devonisches Alter und dessen durch die variszische, synmetamorphe Orogenese geprägter Bau heute als weitgehend gesichert angesehen wird. Großtektonische Untersuchungen zeigen, daß die B-Achsenhauptrichtungen aller im Bereich der Lagerstätte auftretenden Gesteinstypen, einschließlich derer der vererzten Partien, gleichgerichtet sind. Das wird auch durch die Korngefügeuntersuchungen bestätigt: deutlich tritt sowohl eine B- wie auch S-Tektonitregelung hervor, wobei dieser starken Formung auch das makroskopisch sichtbares als (h0l)-Fläche zuordenbar ist und die aus der Tektonitregelung erschließbaren Achsen in ihrer Richtung mit den variszisch angelegten Groß- und Kleinfalten übereinstimmen. Eine die variszische Orogenese überdauernde Thermometamorphose hat die bestehenden Regelungen nicht verwischt, ein Einfluß einer vorvariszischen oder einer alpidischen Phase ist im Korngefüge nicht nachweisbar. Erhalten sind auch Wachstumsgefügeregelungen, die aber wegen ihrer Mehrdeutigkeit keine klaren Schlußfolgerungen über ihre Entstehung erlauben. Die Korngefügeuntersuchungen bestätigen auch, daß der Metasomatose bei der Ausbildung der Lagerstätte in ihrer heutigen Form eine wesentliche Rolle zukommt. Der Nachweis metasomatischer Prozesse sagt aber nichts über den eigentlichen Eisenanreicherungsvorgang aus und bedeutet keinesfalls, daß der Lagerstätteninhalt durch metasomatischen Stoffaustausch zugeführt wurde. Es wird vielmehr auf eine Mobilisation schon primär vorhandenen Eisens durch Druck- und Temperaturerhöhung während der variszischen Orogenese und der damit verbundenen Thermometamorphose geschlossen; die Bruchtektonik der alpidischen Gebirgsbildungsphase konnte solche lagerstättenbildende Prozesse nur mehr in geringem Maß auslösen.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The number and energy spectra of neutrons evaporated by the heavy and light fragments in deep inelastic collisions have been obtained for the system 240 MeV40Ar +197Au. They indicate that at the scission point the deformation energy is a large part of the total excitation energy espe cially for the light fragment. In the last two years, neutron emission has been studied in deep inelastic reactions1−6. All the results are similar: the incident energy which is lost during the process is transformed into excitation energy of the final fragments and is shared between the two products proportionnally to their masses. This means that the nuclear temperature was uniform in the composite system. The excitation energy equilibration time is really very short since equilibration is achieved after reaction times as small as 10−22 s2,6. Moreover, no preequilibrium emission (direct neutrons-) has been observed.
    Type of Medium: Electronic Resource
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