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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 468 (1986), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0039-9140
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 661 (1994), S. 109-118 
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1569-8041
    Keywords: AT ; ataxia teleangiectasia ; Nijmegen-Breakage Syndrome (NBS) ; non-Hodgkin's lymphoma (NHL)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Lymphoma and leukemia are the commonest malignantdiseases in patients with chromosomal breakage syndromes and immunodeficiency(Ataxia teleangiectasia (AT) and Nijmegen breakage syndrome (NBS)). Withimproved management of infections, malignant disease is more frequentlydiagnosed and has become one of the commonest causes of death in pediatric ATand NBS. Patients and methods:In three consecutive multicenter therapytrials for pediatric non-Hodgkin's lymphoma (NHL) (NHL-BFM), 1569 patientswith newly diagnosed NHL have been registered between 1986 and 1997. Ninepatients with AT (n = 5) and NBS (n = 4) were identified andanalysed. Results:Median age of patients with AT and NBS at diagnosis ofNHL was nine years. NHL-entities differed from non-AT/NBS-patients: diffuselarge B-cell lymphomas, n = 7 (78%); ALCL, n = 1;lymphoblastic T-cell lymphoma, n = 1. Cervical nodes, paranasalsinuses and epipharynx were the sites most frequently involved. Stages were:I and II in three patients, III in five and IV in one patient. All patientsreceived polychemotherapy according to tumor-entity and stage, none receivedradiation. Dose reductions according to individual tolerance concerned mainlyethotrexate, alkylating agents and epipodophyllotoxines. One patient died oftoxic complications, two patients relapsed and died, one patient suffered fromsecond malignancy. Five of nine patients are in 1. CCR after a medianfolluow-up of five years. Conclusions:Patients with AT and NBS suffer from rare entitiesof pediatric NHL. Curative treatment is possible and should be attempted.Intensity of therapy should be adjusted to individual risk factors andtolerance. Alkylating agents, epipodophyllotoxines should be omitted, dose ofMTX should be limited to 1 g/m2. Further cooperative trials usingstandardized approaches are required.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1440
    Keywords: Abbreviations ALL Acute lymphoblastic leukemia ; BMT Bone marrow transplantation ; CTL Cytotoxic T-lymphocytes ; IL Interleukin ; MHC Major histocompatibility ; MRD Minimal residual diseaseIntroductionObjective ; The purpose of this protocol is to induce a specific cellular immune reaction after autologous bone marrow transplantation (BMT) by vaccination with human leukocyte antigen (HLA) B13 transfected autologous leukemic cells in children with high-risk relapse of acute lymphoblastic leukemia (ALL). Specific cytotoxic T-lymphocytes (CTL) will be expanded in vivo by low-dose interleukin-2 (IL-2). The expression vector used is the pcDNA3 HLA-B13 plasmid ; driven by a cytomegalovirus promoter. Leukemic cells are transfected by electroporation/ballistomagnetic transfer.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Results of the BMF study group trials ALL-REZ 83 and 85 for relapsed acute lymphoblastic leukemia (ALL) are presented. For children with late marrow relapse, remission rates of about 90% were seen in both studies. In children treated for early marrow relapse, the remission rate in study ALL-REZ 85 was superior (86% vs 62%). The probability of event-free survival for all patients and for those with early marrow relapse was also statistically significant (P〈0.05). Children with T-cell ALL had an extremely unfavourable prognosis in both studies.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1335
    Keywords: Osteosarcoma ; Preoperative chemo-therapy ; Limb salvage ; High dose methotrexate ; Interferon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a cooperative adjuvant chemotherapy study of osteosarcoma (COSS-80), 192 patients were registered from December 1979 to March 1982. Fortyone patients have been excluded from study because of their nonadjuvant situation, therapy-limiting clinical conditions, or inadequate diagnosis. One hundred and fifty-one patients have been randomized to receive either the drug combination bleomycin+cyclophosphamide+dactinomycin (BCD) or cisplatinum (CPL) within a course of sequential multidrug chemotherapy including adriamycin (ADR) and high dose methotrexate (HDMTX). After exclusion of 51 patients with some deviation in history and/or management 100 selected patients were randomized once more to receive in addition or not fibroblast interferon after preoperative chemotherapy and surgical removal of the primary tumor. Patients were stratified for age and sex and for site and extension of tumor as well in both randomizations. Median follow up is now 12 (1–16) months. The expected 2-year disease free survival (DFS) rate of the total doubly randomized group is 78% and of the single randomized group 76%. No difference could be discerned between recombined groups receiving BCD vs CPL or interferon vs no interferon. The effect of preoperative chemotherapy on the tumor was evaluated clinically and by histopathologic grading; 66/85 (78%) patients were judged clinically as responders with pathohistologic verification of this finding in 71% of these cases. No adverse effect arose from delaying definite surgery for preoperative chemotherapy, but initial application of chemotherapy as well as planning, preparing, and performing of the surgical procedure have been facilitated. The majority of patients received some kind of limb-salvage treatment without local recurrences so far. A statistically insignificant but intriguing tendency for a slightly higher incidence of pulmonary metastases after resection as opposed to amputation could be detected. Similar to observations in the previous study COSS-77.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Monatsschrift Kinderheilkunde 147 (1999), S. 15-18 
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Ferntourismus ; Ancylostoma duodenale ; Eosinophilie ; Hypochrome Anämie ; Stuhldiagnostik ; Key words International tourism ; Ancylostoma duodenale ; Eosinophilia ; Hypochromic anemia ; Examination of stool smears
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: Worldwide 400 to 800 Mio people are infected with hookworms. In tropical and subtropical areas an infection with hookworms is the most common reason of eosinophilia and hypochromic anemia. Depending on patients’ weight, age, status of health and nutrition severe medical problems are possible. Case report: In our hospital a 13 year old boy was admitted to clear up an eosinophilia. Atopic, malign, different infectious or drug induced diseases could be excluded. Finally an infection with Ancyclostoma duodenale could be detected in the fourth direct microscopic examination of fecal smears for parasits and worm eggs. A therapy with mebendazole eradicated the hookworm successfully. Discussion: Because of increasing international tourism it is mandatory to include hookworm infections in the differential diagnosis of eosinophilia and hypochromic anemia also in Northern Europe. It must be considered that a sufficient substitution with iron may compensate the anemia and will cover the disease. Therefore sometimes several stool smears have to be examined to detect the infection.
    Notes: Zusammenfassung Hintergrund: Weltweit sind 400–800 Mio. Menschen mit Hakenwürmern infiziert. In den tropischen/subtropischen Gebieten gehört der Befall zu den häufigsten Ursachen einer Eosinophilie sowie hypochromen Anämie. Abhängig von Gewicht, Alter, Gesundheits- und Ernährungszustand sowie Intensität der Infektion können schwere gesundheitliche Schäden auftreten. Fallbericht: Wir berichten über einen 13jährigen Knaben, der zur Diagnostik einer unklaren Eosinophilie eingewiesen wurde. Als Ursache der Eosinophilie konnten Atopien, maligne und verschiedene infektiöse Erkrankungen sowie medikamentös induzierte Formen ausgeschlossen werden. Erst bei der 4. Untersuchung frischer Stuhlproben auf Parasiten und Wurmeier ließ sich eine Infektion mit Ancylostoma duodenale nachweisen, die erfolgreich mit Mebendazol behandelt wurde. Diskussion: Aufgrund des ansteigenden internationalen Reiseverkehrs muß eine Hakenwurminfektion bei unklarer Eosinophilie und hypochromer Anämie auch in unseren Breiten unbedingt differentialdiagnostisch einbezogen werden. Der Nachweis erfordert häufig mehrere Stuhluntersuchungen. Bei guter Eisenversorgung kann die Anämie kompensiert und das Krankheitsbild maskiert werden.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Der Onkologe 5 (1999), S. 920-928 
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Raumfordernde intraokulare Prozesse sind im Kindesalter ein extrem seltenes Ereignis. Alle bekannten intraokularen Tumoren können auch im Kindesalter auftreten, jedoch ist das Retinoblastom der mit Abstand häufigste maligne Tumor in dieser Altersgruppe.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0584
    Keywords: Differential PCR ; Β1-IFN gene loss ; Acute lymphoblastic leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Deletion of the short arm of chromosome 9p involving the Β1-interferon (IFN) gene has been implicated in the process of malignant transformation in lymphomas and acute lymphoblastic leukemias. Since cytogenetic analysis is frequently unsuccessful in clinical samples, we used a recently described differential PCR technique to detect losses within the Β1-IFN gene in 86 acute leukemias. Using differential PCR, no Β1-IFN deletion was detected in 44 acute myeloid leukemia (AML) and eight control samples. However, five of 42 acute lymphoblastic leukemia (ALL) probes (12%) exhibited loss of the Β1-IFN gene (three common ALL, two T-ALL). Cytogenetic analysis was performed independently in three of these five cases and revealed abnormalities of chromosome 9p in two samples. Two of five T-ALL cases exhibited a loss within the Β1-IFN gene, compared with 3/29 c-ALLs, suggesting a predominance of IFN gene loss in T-ALLs. These data indicate that PCR can be used for rapid detection of gene dosage phenomena in clinical leukemia samples.
    Type of Medium: Electronic Resource
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