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  • 2005-2009  (1)
  • 1980-1984  (5)
  • 1975-1979  (2)
  • 1965-1969  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Virus Elimination in Acute Lymphocytic Choriomeningitis Virus Infection Correlation with Virus-Specific Delayed-Type Hypersensitivity rather than Cytotoxicity (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 17 (1983), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The immunological effector mechanism responsible for the elimination of virus in murine acute non-fatal extracranial lymphocytic choriomeningitis virus infection was studied. In this infection virus clearance is generally regarded as the result of a direct action of virus-specific cytotoxic T cells (Tc cells) on virus-producing target cells in the infected mouse. However, by manipulating the antiviral immune response by pretreatment with various doses of cyclophosphamide, we found lack of correlation between Te-cell activity and the clearance of virus. In contrast, we observed a conspicuous correlation between the host's ability to mount a virus-specific delayed-type hypersensitivity (DTH) response and its capacity to combat virus. Moreover, pretreatment with silica and carragheenan prolonged viraemia without impairment of the peak Tc-cell response. These findings indicate that Tc cells have little or no capacity to eliminate virus, at least in the absence of an inflammatory response, and our findings suggest that virus clearance reflects a DTH-like process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1983.tb00816.x
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  • 2
    Electronic Resource
    Electronic Resource
    Fatal Meningitis following Lymphocytic Choriomeningitis Virus Infection Reflects Delayed-Type Hypersensitivity Rather than Cytotoxicity (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 17 (1983), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Fatal meningitis following intracerebral inoculation of lymphocytic choriomeningitis virus (LCMV) reflects an immunopathological lesion believed to be mediated by cytotoxic T cells. The results presented here demonstrate that pretreatment with cyclophosphamide (Cy; 150mg/kg body weight) 2 days before intracerebral infection significantly reduced the lethality of the infection. However, this treatment did not impair the antiviral cytotoxic response as measured in the spleen. On the other hand, virus-specific delayed-type hyper-sensitivity (DTH) was significantly reduced. This reduction seems to be the result of a Cy-induced lack of non-committed ancillary cells since: (1) virus-primed spleen cells from Cy-pretreated donors conferred normal LCMV-specific DTH to naive recipients; (2) transfer of virus-primed spleen cells from untreated donors did not increase the suppressed DTH response of the Cy-pretreated mice: and (3) inoculation of irrelevant antigen and antigen-primed spleen cells into the footpads of Cy-pretreated, infected mice resulted in a significantly reduced footpad swelling as compared with untreated, infected controls. Taken together, these results indicate that LCMV-induced meningitis does not solely represent T-cell-mediated cytotoxicity in vivo but that a fatal outcome of the infection critically involves not only effector T cells but also ancillary cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1983.tb00776.x
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  • 3
    Electronic Resource
    Electronic Resource
    Transient Impaired Cell-Mediated Tumor Immunity after Acute Infection with Lymphocytic Choriomeningitis Virus (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Intraperitoneal injection of nononcogenic lymphocytic choriomeningitis (LCM) virus in adult C3H mice causes a symptomless infection but stimulates specific cell-mediated and humoral immune responses. However, median survival time of virus-infected mice inoculated with syngeneic tumor cells was significantly shortened, and growth of semiallogeneic tumors was significantly enhanced. Cell-mediated cytotoxicity measured as chromium-51 release from labeled tumor cells was significantly suppressed but was recovered within 55 days after infection. The suppressed immune responsiveness could be conferred on a normal spleen cell population when activated in virus-infected recipients. Chronically LCM virus-infected mice showed an unimpaired cell-mediated immune response to tumor allografts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb02633.x
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  • 4
    Electronic Resource
    Electronic Resource
    24-h Monitoring of Calcineurin Phosphatase Activity in Healthy Subjects (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 62 (2005), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The calcineurin inhibitors cyclosporine and tacrolimus are the cornerstone immunosuppressants used in solid organ transplantation. Studies investigating calcineurin (CaN) activity in renal transplanted patients have been published, but basic properties of the enzyme activity in healthy subjects remain to be described. The aim of this study was to investigate whether CaN displays circadian variation or sex difference is present in healthy subjects. Twenty subjects had blood samples drawn every 4 h for a 24-h period. CaN activity was determined in whole blood as the release of 32P from a phosphorylated peptide. Activity of the 32P was quantitated by liquid scintillation and results converted to units CaN utilizing a calibration curve. We found no circadian variation in CaN activity and no difference between the two sexes. The clinical importance of these findings is that blood samples for calcineurin activity can be drawn without taking the exact time of day into consideration, but only considering the time of drug intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.2005.01660.x
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  • 5
    Electronic Resource
    Electronic Resource
    Nickel allergy and osteomyelitis in a patient with metal osteosynthesis of a jaw fracture (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 5 (1979), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 27-year-old female, after a fracture of the mandible treated with osteosynthesis and after a difficult extraction, developed osteomyelitis with fistulation and sequestration. Sequestrectomy and extraction of the teeth in the osleomyelitic area did not clear the patient of symptoms. A patch test to nickel turned out to be positive. After removal of the stainless steel cerclage in the mandible, clinical and radiographic changes returned to normal within 2 and 8 weeks, respectively. It is concluded that, whenever acute treatment docs not lake priority, patch tests comprising nickel, cobalt and chromium should he performed in patterns who are candidates for metal osteosynthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1979.tb04808.x
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  • 6
    Electronic Resource
    Electronic Resource
    Homogeneous mono-125I-insulins (1980)
    Springer
    Diabetologia 19 (1980), S. 546-554 
    Details
    ISSN: 1432-0428
    Keywords: 125I-insulin ; insulin ; radioiodination ; iodate ; lactoperoxidase ; monoiodotyrosine ; diiodotyrosine ; A chain ; B chain ; tyrosine-A14 ; tyrosine-A19 ; insulin immunoassay ; radiochemical purity ; radioimmunochemical stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mono-125I-(Tyr A19)-insulin (Mono *A19) was prepared by iodinating MC porcine insulin with 125I in acid medium using iodate (as oxidizing agent), followed by anion-exchange chromatography. Mono-125I-(Tyr A14)-insulin (Mono *A14) was prepared by iodinating MC porcine insulin with 125I, using H2O2/lactoperoxidase at neutral pH, followed by anion-exchange chromatography. The specific radioactivities were in the ranges of 120–200 and 220–300 mCi/mg for Mono *A19 and Mono *A14, respectively. Analyses of the intramolecular distributions of 125I demonstrated that the preparations were 97–98% radiochemically pure. In both preparations, 98–99% of the radioactivity was capable of binding to insulin antibodies for up to 6 months of storage of the tracers. The IRI concentration decreased with the duration of storage. The greatest observed fall in IRI concentration was 70%. The time course could be explained by the assumption that the disintegration of a 125I-nucleus destroys the immunoreactivity of the insulin molecule in which the decay occurs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253183
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  • 7
    Electronic Resource
    Electronic Resource
    Human proinsulin standards (1984)
    Springer
    Diabetologia 27 (1984), S. 414-415 
    Details
    ISSN: 1432-0428
    Keywords: Human proinsulin ; radioimmunoassay ; standards
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two new batches of pancreatic human proinsulin have been compared with biosynthetic human proinsulin. Standards of these three proinsulin preparations were made on the basis of quantitative amino-acid analyses and compared in two proinsulin radioimmunoassays with a proinsulin standard prepared 14 years ago. The curves of the new standards were superimposable. However, they differed considerably from the curve of the old standard which proved to be only one-third of the strength of the new standards, thereby leading to a threefold over-estimation of proinsulin concentrations when the old standard is used. We conclude that the new standards should replace previously used standards.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304860
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  • 8
    Electronic Resource
    Electronic Resource
    Second Annual Meeting of the European Association for the Study of Diabetes abstracts (1966)
    Springer
    Diabetologia 2 (1966), S. 202-228 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01222072
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Diurnal variation of nitrogen cycling in coastal, marine sediments (1984)
    Springer
    Marine biology 83 (1984), S. 177-183 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A closed chamber technique was developed to determine the emission of microbially produced N2O from an estuarine sediment. A diurnal variation was observed; maximum emissions of 0.4 to 4.0 μmol N2O−N m-2 h-1 were recorded at night whereas the rates were low or even negative, -0.4 to 0.4 μmol N2O−N m-2 h-1, during the day. The bacterial denitrification located in the uppermost centimeter was apparently the major source of the emitted N2O. The diurnal emission pattern was thus inversely related to the O2 availability at the sediment surface; in the dark, the lack of O2 production by benthic photosynthesis allowed the denitrification to occur closer to the sediment-water interface and was likely to enhance the release of N2O to the water. The daily averages for the emission were about 40 μmol N2O−N m-2 d-1 for three investigation periods in autumn (November), winter (February) and spring (April), whereas no significant emission was recorded in the NO 3 - -depleted sediment in early summer (June). In this estuary, the N2O emissions from the sediment were significant contributions to the overall release of N2O to the atmosphere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00394726
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  • 10
    Electronic Resource
    Electronic Resource
    International Symposium on Statistical Quality Control in the Analytical Laboratory (1968)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 243 (1968), S. 751-825 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00530770
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