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  • 1980-1984  (15)
  • 1975-1979  (11)
  • 1965-1969  (9)
  • 1950-1954  (3)
  • 1
    Electronic Resource
    Electronic Resource
    PRELIMINARY ESTIMATES OF THE DOPAMINE β-HYDROXYLASE CONTENT AND ACTIVITY IN PURIFIED NORADRENERGIC VESICLES (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The dopamine β-hydroxylase (DβH) content and activity of large dense-core noradrenergic vesicles purified from bovine splenic nerve were determined using two assay procedures : enzymic activity expressed in Units per mg protein and homospecific activity based on radioimmunoassay expressed in Units per mg DβH antigen. Approximately two-thirds of the total enzyme activity is latent in these vesicles, even after various treatments designed to compromise vesicle integrity. DβH can be completely unmasked by brief treatment with 0.01-0.05% Triton X-100 and activity increases from 0.20 to 0.64 Units per mg vesicle protein. Calculations based on both assay methods suggested that an average of 7% (range 3-15%) of the total vesicle protein was DβH and that the average vesicle contained about 4 molecules of enzyme (range 2-9 molecules). The estimated homospecific activities indicated an average of 25 and 50% (range 18-72%) of the vesicle enzyme was inactive in the various samples using the two antibodies. The vesicle can synthesize up to 30 molecules of noradrenaline/s per molecule of DβH at near optimal substrate concentration, and 60-270 molecules of norepinephrine/s per vesicle. The assumptions used in the various calculations were critically analyzed and, based on the methods employed, it is tentatively considered to be unlikely that there could be more than 5-12 molecules of DβH per vesicle. The possibility that circulating DβH originates primarily, if not exclusively, from the large dense-core vesicle type is considered and the functional implications of the data support the concept of vesicle reuse during several cycles of exocytosis involving a quantal size equal to a fraction of the vesicle transmitter content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb07711.x
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  • 2
    Electronic Resource
    Electronic Resource
    Photophysics of indole in tetramethylsilane solution. Is there a photoionization threshold? (1982)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 86 (1982), S. 4400-4404 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100219a026
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  • 3
    Electronic Resource
    Electronic Resource
    Photophysics of indole. Comparative study of quenching, solvent, and temperature effects by laser flash photolysis and fluorescence (1981)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 85 (1981), S. 670-677 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j150606a012
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  • 4
    Electronic Resource
    Electronic Resource
    The Stone Age Prehistory of Southern Africa (1983)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Anthropology 12 (1983), S. 25-48 
    Details
    ISSN: 0084-6570
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Ethnic Sciences , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.an.12.100183.000325
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  • 5
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    Effects of stress on attachment behavior in infants (1978)
    Provincetown, Mass., etc. : Periodicals Archive Online (PAO)
    The Journal of Genetic Psychology. 132:2 (1978:June) 321 
    Details
    ISSN: 0022-1325
    Topics: Psychology
    Notes: REPLICATIONS AND REFINEMENTS
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3284-1978-132-02-000021
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  • 6
    Electronic Resource
    Electronic Resource
    Pressure and temperature effects on human red cell cation transport (1982)
    Springer
    The journal of membrane biology 68 (1982), S. 47-56 
    Details
    ISSN: 1432-1424
    Keywords: hydrostatic pressure ; potassium flux ; erythrocyte membrane ; water of hydration ; anion effect ; thermodynamic analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The effects of hydrostatic pressure and temperature on the three components of K+ uptake in human red cells have been investigated, using ouabain and bumetanide to distinguish between the pump, passive diffusion and cotransport. The pressure sensitivity for passive diffusion has been shown to depend on the counter-ion present. The order of this effect, Cl−〉Br−〉NO 3 − 〉I−, is the same as for the ionic partial modal volumes and the Hofmeister series. We have analyzed our experimental results thermodynamically, and propose a model for the activated transition-state complex of the potassium ion which involves the loss of water molecules from the secondary hydration shell, cosphere II.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01872253
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  • 7
    Electronic Resource
    Electronic Resource
    Interaction of alkyl ammonium derivatives with red cells: Hemolysis and sodium pump inhibition studies (1980)
    Springer
    The journal of membrane biology 55 (1980), S. 123-131 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Members of four homologous series of tetra-alkyl ammonium bromides (R 3N+(CH2) n−1·CH3Br− whereR=H, CH3 or C2H5 andR′N+H3Br− whereR′ represents the isomeric butyl series) have been synthesized and tested as sodium pump inhibitors, measured as ouabain-sensitive K+ influx, and as hemolytic agents on human red cells. Potency for both effects is presented graphically, plotting the logarithm of the concentration for half maximal effect against alkyl chain length. Both hemolysis and pump inhibition studies yielded a biphasic response consisting of two good straight lines, with effectiveness increasing up to C10–12 and then remaining constant up to C20. For hemolysis the alkyl ammonium series was most effective. The calculated free-energy change per methylene group was the same for three series of compounds, but the free-energy contribution from the headgroup was lower for the ammonium series. In contrast, although pump inhibition studies also yielded simple biphasic plots, inhibition occurred at 3- to 50-fold lower concentrations and there were significant differences between the three series, both in the free-energy changes per methylene group and in the headgroup contributions. We have analyzed these results thermodynamically to take account of hydrophobic interactions and the conformation of the alkyl chains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01871154
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  • 8
    Electronic Resource
    Electronic Resource
    Differenzierung der Proteinurie durch die Mikroelektrophorese in kontinuierlichen Polyacrylamid-Gradientengelen (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 19-24 
    Details
    ISSN: 1432-1440
    Keywords: Polyacrylamide-gradient gels ; microelectrophoresis ; proteinuria ; glomerulonephritis ; Polyacrylamid-Gradientengele ; Mikroelektrophorese ; Proteinurie ; Glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über die Anwendung der Mikroelektrophorese in Polyacrylamid-Gradientengelen zur Differenzierung der Proteinurie bei Glomerulonephritis berichtet. Die zeitlichen und methodischen Vorteile dieser Elektrophorese erlauben eine routinemäßige Durchführung in der Klinik. Durch die Auftrennung der Urinproteine nach ihrer Molekulargröße und Form lassen sich vier Proteinuriemuster unterscheiden: kleinmolekular, mittelmolekular, intermediär und hochmolekular. Glomerulonephritisformen, die konstante morphologische und klinische Veränderungen zeigen (z.B. minimal proliferierende Glomerulonephritis, mesangioproliferative Glomerulonephritis mit diffuser Halbmondbildung), lassen eine Zuordnung ihrer Proteinurie zu einem der vier Proteinuriemuster zu, während bei den anderen Glomerulonephritisformen (z.B. perimembranöse Glomerulone-phritis, mesangioproliferative Glomerulonephritis) eine Abhängigkeit des Proteinuriemusters von der Glomerulonephritisphase vermutet wird.
    Notes: Summary It is possible to differentiate the proteinuria of glomerulonephritis by means of microelectrophoresis in polyacrylamide-gradient gels. The advantages of this method (quick, cheap, concentration of the urine not required) led to its introduction into clinical use. Upon separating the urinary proteins according to their molecular weight and form, four patterns of proteinuria may be differentiated: low molecular, middle molecular, intermediate and high molecular. Those forms of glomerulonephritis which show constant morphological and clinical findings (e.g. minimal proliferative glomerulonephritis, mesangioproliferative glomerulonephritis with crescents) can be related to one of the four patterns of proteinuria, whereas the pattern of proteinuria in other forms of glomerulone-phritis (e.g. (peri-)membranous glomerulonephritis, mesangioproliferative glomerulonephritis) are dependent on the phase of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01466982
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  • 9
    Electronic Resource
    Electronic Resource
    Efficacy of a virion envelope herpes simplex virus vaccine against experimental skin infections in hairless mice (1981)
    Springer
    Archives of virology 68 (1981), S. 73-80 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hairless mice were immunized with herpes simplex virus type 1 (HSV-1) envelope antigen (EAG), EAG in association with polyriboinosinic · polyribocytidylic acid-poly-L-lysine complexed with carboxymethylcellulose (PICLC), and inactivated purified HSV-1 (VAG). After 2 weeks the mice were challenged by a percutaneous HSV-1 infection in the orofacial (OF) or lumbosacral (LS) skin area. Following immunization a consistent cell-mediated immune response was observed in all immunized mice, although the humoral immune response was very low, or not detectable. After challenge, a marked secondary humoral and cell-mediated immune response developed in all immunized mice, and the animals were protected against the development of skin lesions and the fatal outcome of infection. However, the establishment of latent infections in the sensory ganglia was not prevented by the immunization procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314437
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  • 10
    Electronic Resource
    Electronic Resource
    The pathogenesis of acute, latent and recurrent herpes simplex virus infections (1982)
    Springer
    Archives of virology 72 (1982), S. 143-168 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01348961
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