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  • 1985-1989  (640)
  • 1935-1939
  • 1986  (640)
  • Engineering  (497)
  • pharmacokinetics  (143)
  • 101
    Electronic Resource
    Electronic Resource
    The intra- and inter-subject variability of Nifedipine pharmacokinetics in young volunteers (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 57-60 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; pharmacokinetics ; oral contraceptives ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma concentrations of Nifedipine were measured following single oral doses of Nifedipine Slow Release (Adalat Retard) on three separate occasions to young, healthy volunteers of both sexes. Intra- and inter-subject variability were assessed by comparing the pharmacokinetic parameters, AUC, Cmax and T50%AUC. Interindividual variability was less than that observed in other studies with the betablockers, metoprolol and propranolol and there was no evidence of differences between the sexes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614196
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  • 102
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and pharmacodynamics of the prostacyclin analogue iloprost in man (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 61-68 
    Details
    ISSN: 1432-1041
    Keywords: iloprost ; prostacyclin analogue ; pharmacokinetics ; platelet aggregation ; healthy male volunteers ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma levels of the prostacyclin analogue, iloprost, were measured by antibody/GC/MS in healthy male volunteers given 1 and 3 ng/kg per min i.v. for 45 min, and 1 µg/kg p.o. Following i.v. infusion, the steady-state plasma levels of iloprost were strictly dose-dependent (46±8 pg/ml and 135±24 pg/ml). The disposition was biphasic with half-lives of 3–4 min and 0.5 h. After oral administration, absorption of the drug was extremely rapid, the maximum plasma level of 251±32 pg/ml being achieved after 10±6 min. The bioavailability was 16±4%. Platelet aggregation induced by 2 µM ADP was reduced by 53% and 68% at the end of the two different infusions, and by 68% 15 min after p.o. administration. The ex-vivo inhibition of platelet aggregation by iloprost was not affected by preceding drug treatment. The cAMP content of platelets was increased by a factor of 2.5 at the end of the infusions and to a lesser extent 15 min after oral dosing. A slight increase in heart rate occurred during the infusion and within 30 min after oral administration; blood pressure was virtually unaffected. Except for transient side-effects (facial flush and headache) no adverse reactions were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614197
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  • 103
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of methysergide and its metabolite methylergometrine in man (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 75-77 
    Details
    ISSN: 1432-1041
    Keywords: methysergide ; methylergometrine ; first-pass metabolism ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Five healthy men were given 1.0 mg methysergide maleate intravenously and 2.7 mg methysergide maleate orally in a cross-over study. The systemic availability of methysergide was only 13%, most probably due to a high degree of first-pass metabolism to methylergometrine. We also found evidence of extrahepatic clearance of methysergide. After oral administration the plasma concentrations of the metabolite were considerably higher than those of the parent drug and the area under the plasma concentration curve (AUC) for methylergometrine was more than ten times greater than for methysergide. Our findings may be relevant to the treatment of migraine if methylergometrine contributes to the effect of methysergide. Methylergometrine had a significantly longer elimination half-life than methysergide (223±43 min vs 62.0±8.3 min and 174±35 min vs 44.8±8.1 min in the oral and intravenous studies respectively).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614199
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  • 104
    Electronic Resource
    Electronic Resource
    Effect of cirrhosis and renal failure on the kinetics of clotiazepam (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 89-92 
    Details
    ISSN: 1432-1041
    Keywords: clotiazepam ; liver cirrhosis ; renal insufficiency ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The kinetics of a single 5-mg oral dose of the thienodiazepine clotiazepam was evaluated in a series of patients with biopsy-proven cirrhosis, and in patients with renal insufficiency requiring maintenance hemodialysis, compared to healthy matched controls. Clotiazepam volume of distribution (Vz) was significantly smaller in cirrhotic patients than in controls (1.83 vs 2.57 l/kg), and total clearance was likewise reduced (2.15 vs 3.15 ml/min/kg). Elimination half-life was similar between groups (10.0 vs. 10.2h). There were no significant differences between renal failure and control patients in clotiazepam Vz, oral clearance, or elimination half-life. Thus cirrhosis is associated with reduced clearance of clotiazepam, probably due to impairment of its microsomal oxidation. However clotiazepam disposition is not significantly altered in dialysis-dependent renal insufficiency patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614202
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  • 105
    Electronic Resource
    Electronic Resource
    The effects of age and chronic liver disease on the elimination of temazepam (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 93-97 
    Details
    ISSN: 1432-1041
    Keywords: temazepam ; liver disease ; elimination ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of the newer 1, 4 benzodiazepine temazepam were evaluated in 16 healthy subjects aged 18–92 years and in 15 cirrhotic patients, to ascertain the effect of ageing and liver disease. The data were analysed both by classic two compartment and by non-compartmental methods. The mean elimination half-life in the control subjects was 15.5 h, considerably longer than previous estimates. No correlation was found between age and pharmacokinetic parameters. The cirrhotic group showed no statistically significant difference in the pharmacokinetic parameters nor in the urinary recovery of the dose from the control group. Temazepam plasma protein binding was assessed in a second group of 9 cirrhotics of similar severity to the main group and in matched controls. When these binding data were applied to the mean clearance data, a modest although not statistically significant, reduction in free drug clearance was observed in the cirrhotic group. This study adds further support to the observation that drugs which undergo ether glucuronidation have normal elimination patterns in patients with liver disease. Temazepam may prove to be a useful hypnotic sedative in patients with liver disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614203
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  • 106
    Electronic Resource
    Electronic Resource
    Cirrhosis of the liver markedly impairs the elimination of mexiletine (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 83-88 
    Details
    ISSN: 1432-1041
    Keywords: mexiletine ; cirrhosis of the liver ; antiarrhythmic agents ; pharmacokinetics ; intravenous administration ; protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To study the effects of cirrhosis of the liver on the pharmacokinetics of mexiletine a single i.v. dose of 200 mg was administered to six cirrhotic patients and to six healthy controls. The distribution of mexiletine in both study groups was similar, as indicated by similar values of V1 and Vss, but it tended to occur more slowly in the cirrhotics. The plasma protein binding of mexiletine was unchanged in the patients with cirrhosis. The elimination of mexiletine was markedly retarded in the cirrhotics, as indicated by its lower total clearance (2.31 vs. 8.27 ml/kg/h,) lower total elimination rate constant (0.059 vs 0.353 h−1), and longer elimination half-life (28.7 vs 9.9 h). The antipyrine half-life was 38.3 h in the patients and 14.7 h in the controls. One healthy volunteer had a Morgagni-Stokes-Adams type of syncopal attack 5 min after administration of mexiletine due to disturbance of AV conduction induced by the drug. Thus, on a pharmacokinetic basis the loading dose of mexiletine need not be modified in cirrhotic patients, whereas the maintenance dosage should be reduced to one fourth — one third of the usual dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614201
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  • 107
    Electronic Resource
    Electronic Resource
    Ceftriaxone pharmacokinetics following multiple intramuscular dosing (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 109-112 
    Details
    ISSN: 1432-1041
    Keywords: ceftriaxone ; intramuscular ; pharmacokinetics ; steady-state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The steady-state pharmacokinetics and tolerance of ceftriaxone after multiple i.m. doses of 0.5 and 1 g q12 h for 3.5 days were investigated in 12 healthy, adult volunteers. Ceftriaxone was rapidly absorbed after i.m. administration with mean peak times ranging from 1.3 to 1.9 h. Steady-state plasma concentrations were apparent after the third dose of both dosage regimens, with trough plasma concentrations of 24±6 and 39±8 µg/ml (mean±SD) after the 0.5 and 1 g q12 h regimens, respectively. Multiple i.m. administrations of ceftriaxone did not alter its elimination half-life; however, small increases were observed in the plasma clearance and volume of distribution at the 1-g regimen. These increases were attributed to the non-linear binding of ceftriaxone to human plasma proteins, and are therapeutically unimportant. Ceftriaxone was well tolerated and serious or lasting adverse reactions were not encountered in the study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614206
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  • 108
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of dezocine, a new analgesic: Effect of dose and route of administration (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 121-123 
    Details
    ISSN: 1432-1041
    Keywords: dezocine ; opioid analgesics ; pharmacokinetics ; healthy volunteers ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of intravenous (IV) dezocine, and bioavailability of intramuscular (IM) and subcutaneous (SQ) dezocine, were evaluated in healthy male volunteers. Elimination half-life following 5, 10, and 20 mg IV doses averaged 2.6–2.8 h, and was independent of dose. Clearance decreased slightly, although significantly, with dose. After Deltoid IM injection, dezocine was rapidly absorbed (peak level: 0.6 h after dose), with bioavailability 97%. Thus dezocine has extensive distribution, high clearance and short half-life over a range of IV doses. It is rapidly and completely absorbed following IM or SQ administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614208
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  • 109
    Electronic Resource
    Electronic Resource
    Comparison of single and multiple dose pharmacokinetics of theophylline using stable isotopes (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 113-120 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; pharmacokinetics ; stable isotopes ; diurnal variation ; single dose administration ; multiple dose administration ; systemic availability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Theophylline, enriched with the stable isotopes13C and15N, was administered intravenously in a dose of 10 mg to 8 healthy men following single (200 mg) and multiple (200 mg 8-hourly for 5 days) oral dose administration of aminophylline. Total plasma clearance, volume of distribution, and half-time determined from the intravenous data were similar, demonstrating that the pharmacokinetics of theophylline after chronic dosing can be predicted from the pharmacokinetics of a single dose. With chronic oral dosing, however, the mean trough concentration was 12% higher at 9 a.m. than at 5 p.m., the end of the dose interval (3.94±0.55 vs. 3.50±0.45 µg·ml−1). The AUC following oral dosing was 25% higher in the multiple dose study than in the single dose study. Simulation analysis suggested that these results could be explained by diurnal variation in the clearance or absorption rate or a combination of both. Thus, the systemic availability of theophylline measured during a single dosage interval after chronic oral dosing to steady state would be overestimated in comparison with that measured after a single oral dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614207
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  • 110
    Electronic Resource
    Electronic Resource
    Single dose oxazepam has no effect on acetaminophen clearance or metabolism (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 127-129 
    Details
    ISSN: 1432-1041
    Keywords: oxazepam ; acetaminophen clearance ; metabolite formation ; glucuronidation ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The metabolism of acetaminophen and oxazepam in humans is mainly dependent on the microsomal capacity for glucuronide conjugation. The clearance of acetaminophen and the formation of metabolites were evaluated in 7 patients before and during concomitant administration of oxazepam 30 mg. The subjects received a single 500 mg dose of acetaminophen i.v. and concentrations in plasma were measured for 360 minutes and in urine for 24 h in order to estimate the production of metabolites. The single therapeutic dose of oxazepam had no effect on the clearance of acetaminophen or on formation of its metabolites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614210
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  • 111
    Electronic Resource
    Electronic Resource
    Treatment of essential hypertension with felodipine in combination with a diuretic (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 133-139 
    Details
    ISSN: 1432-1041
    Keywords: felodipine ; hydrochlorothiazide ; essential hypertension ; calcium antagonist ; pharmacokinetics ; plasma noradrenaline ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a double-blind cross-over study, the effect on blood pressure (BP), heart rate (HR) and plasma noradrenaline concentration (pNA) of placebo or felodipine given in addition to hydrochlorothiazide was studied in 12 male patients with essential hypertension, not satisfactorily controlled with the diuretic alone. The first dose of felodipine decreased BP and increased HR for about 6 h. After 4 weeks of treatment with felodipine, BP was reduced for 24 h, whereas HR was only transiently increased. The elimination half-life of felodipine was about 23 h. The plasma noradrenaline concentration increased after felodipine and serum uric acid decreased. Side-effects were few and usually mild.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614290
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  • 112
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and pharmacodynamics in man of the dopamine antagonist ergot derivative, bromerguride (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 165-168 
    Details
    ISSN: 1432-1041
    Keywords: bromerguride ; dopamine antagonist ; pharmacokinetics ; pharmacodynamics ; prolactin level ; side-effects ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma levels and urinary excretion of the dopamine antagonist, bromerguride, were measured by radioimmunoassay in healthy male volunteers given 50 µg i.v. and oral doses of 1 and 2 mg. Plasma prolactin was also measured by radioimmunoassay. Following i.v. injection, the concentration of bromerguride declined biphasically, with half-lives of 7 min and 1.2h. The total clearance was 32 ml·min−1·kg−1 and the apparent volume of distribution was 3.6 l/kg. The bioavailability of oral bromerguride was 29% after 1 mg and 25% after 2 mg. The drug was almost totally metabolized and less than 0.05% of the dose was excreted in urine in 24 h after oral administration. Plasma prolactin levels were increased in a dose-dependent manner for about 8 h. Side-effects were minimal, mainly being tiredness and headache in some of the volunteers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606653
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  • 113
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of tenoxicam in patients with impaired renal function (1986)
    Springer
    European journal of clinical pharmacology 29 (1986), S. 697-701 
    Details
    ISSN: 1432-1041
    Keywords: tenoxicam ; renal insufficiency ; non-steroidal antiinflammatory agents ; protein binding ; metabolism ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of tenoxicam after a single oral dose of 20 mg has been studied in 12 patients with various degrees of decreased renal function. Unchanged tenoxicam and its 5′OH-metabolite in plasma and urine were determined by HPLC. The mean areas under the plasma concentration-time curve (138±53 µg/ml·h) and terminal half-lives in patients with impaired renal function did not differ from values previously reported in normal volunteers, nor did the peak concentration of tenoxicam. The half-life of 5′OH-tenoxicam and unchanged tenoxicam where the same. The urinary excretion of 5′OH-tenoxicam fell with decreasing renal function. Thus no dosage adjustment should be necessary and the usual daily dose of tenoxicam may be administered once daily also to patients with renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00615961
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  • 114
    Electronic Resource
    Electronic Resource
    The pharmacokinetics after intravenous and oral administration in man of theα 2-adrenoreceptor antagonist idazoxan (RX781094) (1986)
    Springer
    European journal of clinical pharmacology 29 (1986), S. 743-745 
    Details
    ISSN: 1432-1041
    Keywords: idazoxan ; pharmacokinetics ; alpha 2-adrenoceptor antagonist ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A high performance liquid chromatographic method was developed for the quantitative determination of idazoxan in plasma. The assay was used to study the disposition of the drug after intravenous infusion and oral administration to five normal subjects. After i.v. administration the kinetics could be described by a two compartment model with a mean elimination half life of 4.20 h. The mean calculated volume of distribution during the elimination phase was 3.20 l/kg−1 and the mean plasma clearance was 824 ml min−1. After oral administration a lag period before onset of absorption was observed in all five volunteers, the plasma levels declining monoexponentially from the peak concentration with a mean elimination half life of 5.58 h. The absolute availability varied between 26% and 41% with a mean value of 34%. Invitro measurements produced a blood/plasma ratio of 1.3 for idazoxan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00615972
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  • 115
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of temazepam in geriatric patients (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 745-747 
    Details
    ISSN: 1432-1041
    Keywords: temazepam ; pharmacokinetics ; geriatric patients ; benzodiazepines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A single dose of temazepam 10 mg, as a solution in soft gelatin capsules, was given to 10 fasting geriatric in-patients (mean age 83 years) in a stable clinical condition. The mean peak plasma concentration was 306 ng/ml, with a median time of 0.75 h to peak concentration. Temazepam was eliminated from plasma in a biexponential manner, with a distribution phase (mean t1/2α=0.7 h) predominating for 3 h. The drug had a mean elimination half-life of 8.7 h. In a chronic study, in which temazepam 10 mg p.o. was given nightly to 13 patients, the plasma concentrations on Days 3, 5, 8, 12 and 15 were not significantly different from each other, showing rapid attainment of steady state levels and the lack of drug accumulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00608229
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  • 116
    Electronic Resource
    Electronic Resource
    5-Aminosalicylic acid in patients with an ileo-rectal anastomosis (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 23-26 
    Details
    ISSN: 1432-1041
    Keywords: sulphasalazine ; Pentasa ; slow release preparation ; 5-aminosalicylic acid ; ileo-rectal anastomosis ; ulcerative colitis ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of 5-aminosalicylic acid (5-ASA) from sulphasalazine (SASP) and the slow-release 5-ASA preparation Pentasa was investigated in a cross-over study in 9 otherwise healthy patients with an ileo-rectal anastomosis. The 24-hour recoveries of the drugs were 90.5% and 84.7%, respectively. The median release of 5-ASA from SASP was 50% and from Pentasa 75%. Equal amounts of 5-ASA (18.0% vs 17.9%) were found in the faeces, and a significantly larger amount (4.4% vs 28.9%) of the metaboliteN-acetyl-5-aminosalicylic acid (ac-5-ASA) was found in faeces following Pentasa. A larger amount of 5-ASA was absorbed and subsequently excreted in the urine, mainly as the metabolite (2.5% vs 20.5%) from Pentasa. This confirms previous results in ileostomized patients treated with Pentasa. The present findings also demonstrate that bacterial azo-reduction of SASP in patients with ileorectal anastomosis may be an adequate way to deliver 5-ASA in this type of patient. Both treatments may be used in these patients during a flare up of ulcerative colitis, but randomized studies are needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870980
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  • 117
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 69-72 
    Details
    ISSN: 1432-1041
    Keywords: quinidine ; sparteine ; pharmacokinetics ; drug oxidation ; polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and metabolism of quinidine were investigated in extensive and poor metabolisers of sparteine. No differences in plasma clearance, terminal half life, volume of distribution or cumulative urinary excretion of quinidine, 3-hydroxyquinidine and quinidine-N-oxide were observed between phenotypes. Thus, it is unlikely that quinidine metabolism is controlled by the sparteine/debrisoquine gene locus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870989
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  • 118
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of intravenous and intraperitoneal ceftriaxone in chronic ambulatory peritoneal dialysis (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 479-483 
    Details
    ISSN: 1432-1041
    Keywords: ceftriaxone ; dialysis ; continous ambulatory peritoneal dialysis ; pharmacokinetics ; intraperitoneal administration ; intravenous administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The kinetics of ceftriaxone was investigated in 8 patients without infection, who were receiving continuous ambulatory peritoneal dialysis (CAPD). Ceftriaxone 1 g was injected i.v. and 1 g was given intraperitoneally in the CAPD fluid during a 4-h dwell time. Ceftriaxone was assayed by HPLC. After intravenous administration, the kinetic parameters of ceftriaxone were: plasma t1/2, 12.3 h, total plasma clearance, 14.0 ml/min, volume of distribution at steady state 0.18 l/kg, and peritoneal clearance 0.59 ml/min. Over 72 hours only 5.5% of the dose was eliminated by the peritoneal route. After intraperitoneal administration, ceftriaxone rapidly appeared in serum; the absorption t1/2 was 1.1 h and the mean peak concentration was 38.8 µg/ml. The absorption of ceftriaxone from the peritoneal space was 39%. A single 1.0 g IP dose led to serum and dialysate concentrations of ceftriaxone above the minimum inhibitory concentration for susceptible pathogens for 24 hours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613528
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  • 119
    Electronic Resource
    Electronic Resource
    Diuretic activity, safety and pharmacokinetics of torasemide during chronic treatment in normal subjects (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 1-7 
    Details
    ISSN: 1432-1041
    Keywords: torasemide ; diuretic activity ; pharmacokinetics ; healthy subjects ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Torasemide 40 mg/day p.o. was administered for 21 days to 8 healthy volunteers to investigate its pharmacodynamics, pharmacokinetics and safety on chronic administration. It induced a highly significant initial increase in 24-h urinary volume and 24-h excretion of sodium and chloride, but its affect diminished after the first days. On Days 0, 1, 10 and 21 the experiement was divided in 3 clearance phases, extending from 0 to 2 h, 2 to 6 h and 6 to 24 h after dosing. The fractional excretion of sodium, chloride, potassium, calcium, magnesium and inorganic phosphates peaked during the first 2 h and returned almost to the control value during the following two clearance phases. The phase-dependent changes were significant for all electrolytes, except for potassium and inorganic phosphate. Plasma electrolyte levels remained constant throughout the study, except for a small decrease in chloride and potassium and for an increase in calcium and magnesium. Fasting blood glucose and glucose tolerance test were unaffected. A small but significant decrease in LDL-cholesterol was observed on Day 10. Other plasma lipid components showed minor changes. Plasma uric acid levels were moderately increased. There was no significant change of the creatinine clearance. Body weight fell significantly (by about 2 kg) during the study. Tonal audiometry was normal before and after the study. There was no significant difference between the plasma levels of torasemide on Days 1, 10 and 21, nor between its elimination half-life on Days 1 and 21. Side-effects consisted mainly of fatigue and low-back pain on days of intense diuresis. There were no toxic symptoms. ECG recordings and blood pressure remained within normal limits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541460
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  • 120
    Electronic Resource
    Electronic Resource
    Comparative analysis of the pharmacokinetics of unsubstituted N1-derivatives of 1,4-benzodiazepine (1986)
    Springer
    Bulletin of experimental biology and medicine 101 (1986), S. 206-209 
    Details
    ISSN: 1573-8221
    Keywords: 1,4-benzodiazepines ; pharmacokinetics ; plasma/brain concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00836121
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  • 121
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of a water-soluble antioxidant of 3-hydroxypyridine type (1986)
    Springer
    Bulletin of experimental biology and medicine 101 (1986), S. 333-335 
    Details
    ISSN: 1573-8221
    Keywords: antioxidant ; 3-hydroxypyridines ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00835938
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  • 122
    Electronic Resource
    Electronic Resource
    Radioimmune and radioreceptor study of the pharmacokinetics of the enkephalin analog dalargin in man (1986)
    Springer
    Bulletin of experimental biology and medicine 101 (1986), S. 783-785 
    Details
    ISSN: 1573-8221
    Keywords: dalargin ; pharmacokinetics ; enkephalins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00839605
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    A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 261-288 
    Details
    ISSN: 1573-8744
    Keywords: hepatic elimination ; hepatic clearance ; availability ; intrinsic clearance ; pharmacokinetics ; dispersion model ; well-stirred model ; tube model ; distributed model ; blood flow ; binding within blood ; hepatocellular enzyme activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The dispersion model of hepatic elimination is based on the distribution of residence times of blood elements within the liver. The model has two asymptotic solutions corresponding to the “wellstirred” model (complete mixing of blood elements) and the “parallel-tube” model (no variation in residence times of blood elements). The steady-state form of the dispersion model relevant to pharmacokinetic analysis is developed and explored with respect to changes in blood flow, in binding within blood, and in hepatocellular enzyme activity. Literature data are used to evaluate discrepancies among the predictions of the dispersion, well-stirred, and tube models. It is concluded that the dispersion model is consistent-with the data. The limitations of steady-state perfusion experiments to estimate the residence time distribution of blood elements within the liver are considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01106707
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  • 124
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    In vivo interaction of the enantiomers of disopyramide in human subjects (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 335-356 
    Details
    ISSN: 1573-8744
    Keywords: disopyramide ; pharmacokinetics ; stereoisomers ; antiarrhythmic agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Disopyramide, an antiarrhythmic agent, is marketed as a racemic mixture of two enantiomers. The racemic drug has unusual pharmacokinetic properties because of its concentration-dependent binding to plasma proteins in the therapeutic plasma concentration range. This study examined, in healthy subjects, the individual pharmacokinetic properties of both total and unbound d-and ldisopyramide in plasma after intravenous administration of each enantiomer separately (1.5mg/kg).Also investigated is the pharmacokinetics of total d-and l-disopyramide in plasma after intravenous administration of a pseudoracemate. Both d-and l-disopyramide are found to exhibit concentration-dependent binding to plasma proteins, with d-disopyramide being more avidly bound at lower concentrations. The stereoselective, concentration-dependent binding to plasma proteins resulted in distinct pharmacokinetic properties when the enantiomers were given together as the pseudoracemate. d-Disopyramide had a lower plasma clearance and renal clearance, a longer half-life, and a smaller apparent volume of distribution than l-disopyramide. However, when the enantiomers were administered separately, there were no differences in the clearance, renal clearance, and volume of distribution between enantiomers calculated from either total or unbound drug concentrations. The results reveal an important pharmacokinetic interaction between the enantiomers of disopyramide when given as a racemic mixture, which may be dose-dependent and is not apparent upon administration of the enantiomers separately.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059195
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    The impact of neglecting nonlinear plasma-protein binding on disopyramide bioavailability studies (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 365-379 
    Details
    ISSN: 1573-8744
    Keywords: disopyramide ; bioavailability ; protein binding ; nonlinear ; sustained release ; pharmacokinetics ; ultrafiltration ; immunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Disopyramide has nonlinear protein binding and thus the relationship between the extent of its bioavailability and AUC,the area under the plasma concentration-time curve, is (1) nonlinear and (2) absorption rate-dependent. The unbound species follows linear pharmacokinetics. A solution of disopyramide, the innovator's product, and two generic formulations were found to be statistically indistinguishable in their bioavailability of disopyramide, whether comparison was based upon AUCor area under the plasma unbound concentration-time curve (AUCu).The AUCand AUCugave similar results because of truly similar bioavailability, coupled with sufficiently similar release rates, among the four preparations chosen for study. The concentration dependence of disopyramide protein binding and the time course of unbound plasma concentrations were fit by models which then allowed prediction of AUCunder various biopharmaceutical scenarios. Nonlinear binding of disopyramide to plasma proteins renders AUCan insensitive parameter for the discrimination of products with different extents of bioavailability; immediate release products allowing bioavailabilities of 75 or 125% relative to the solution can generate AUCs86 and 112%, respectively, of that from the solution. Nonlinear binding, furthermore, leads to a tendency for AUC tooverestimate the bioavailability of slower release products in single-dose studies; if AUCwere the index of bioavailability, products permitting the same bioavailability as the solution but releasing over 12 hr could appear to allow 114% relative bioavailability. Moreover, in some situations the bias arising from the insensitivity of AUCto product differences can be reinforced by the dependence of AUCon release rate; an apparent relative bioavailability of 80% can be achieved by a 12-hr release product allowing a true relative bioavailability of a mere 58%. While multiple-dose studies appear largely to avoid the tendency to overestimate low bioavailability in slow-release products, in these studies AUCappears to be even more insensitive in resolving discrepancies between products. Assay technology now available makes AUCua feasible and more reliable index of bioavailability than AUCwhen plasma protein binding of drugs is nonlinear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059197
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  • 126
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    On the pharmacokinetics of 16-acetyl-gitoxin and its bioavailability from pengitoxin-containing tablet formulations (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 357-364 
    Details
    ISSN: 1573-8744
    Keywords: 16-acetyi-gitoxin ; pengitoxin ; pharmacokinetics ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In six volunteers the pharmacokinetics of 16-acetyI-gitoxin (16AG, 0.5mg) administered intravenously (A1) and as an oral solution (A2) and of pengitoxin (PAG, 0.6 mg) administered intravenously (A3) was evaluated. In six volunteers the bioavailability of 16AG from two PAG tablet formulations (1.2 mg) (B2, B3) was measured by comparison with the absorption after administration of a pengitoxin solution (1.2mg) (B1). In both studies the test was performed using a crossover design. After a single i.v. injection of equimolar doses, 16AG and PAG showed similar mean kinetic parameters: t 1/2 =51.6hr (16AG) and 60.8 hr (PAG), CL=11.7ml min−1 (16AG) and 12.7ml min−1 (PAG), CLR=4.1 ml min−1 (16AG) and 4.2ml min−1 (PAG). The 16AG was absorbed from solution with a mean half-life of 0.2hr to an extent of 98.6%. The mean urinary excretion /Ae(0, 4)/ of 16AG amounted to 24.6% (A1), 20.8% (A2) and 28.1% (A3). On the basis of AUCvalues, the mean bioavailability of PAG from either tablet formulation amounted to 79.6% (B2) and 89.6% (B3). The pharmacokinetic parameters of 16AG (PAG) are closer to those of digitoxin than those of digoxin. In general, 16AG is characterized as a digitoxin with a digoxin-like elimination half-life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059196
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  • 127
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    Pharmacokinetics of isosorbide dinitrate and its mononitrate metabolites after intravenous infusion (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 1-17 
    Details
    ISSN: 1573-8744
    Keywords: isosorbide dinitratekw]isosorbide 2-mononitrate ; isosorbide 5-mononitrate ; metabolism ; pharmacokinetics ; modeling ; simultaneous estimation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Plasma concentrations of isosorbide dinitrate (ISDN) and its two active metabolites 2-isosorbide mononitrate (2-ISMN) and 5-isosorbide mononitrate (5-ISMN) have been measured during and for 6 hr after intravenous infusion at a rate of 2.5mg/hr during 1.75 hr in six cardiac patients, by a capillary gas chromatographic method. Data were analyzed by simultaneous modeling of the observed kinetics of the three compounds. Two or three phases were detected on the postinfusion ISDN concentration-time curves. ISDN concentrations declined with a mean terminal half-life of 2.81 hr±0.7 SD. The mean systemic clearance of ISDN (2.9 L/min ±0.7 SD) and its mean total volume of distribution (259 L +- 48 SD) were relatively high. Plasma 5-ISMN concentrations were 5- to 6-fold greater than those of 2-ISMN during the whole observation period. Maximum levels of 2-ISMN (6.7 ng/ml ± 0.9 SD) and of 5-ISMN (27 ng/ml ± 6 SD) occurred within a few minutes after the end of infusion. The mean half-lives of 2-ISMN (1.59 hr± 0.19 SD) and of 5-ISMN (3.78 hr± 0.79 SD) estimated by the model were smaller than those calculated by a model-independent method (2.95 hr± 0.41 SD and 5.98 hr± 2.22, respectively), but were in good agreement with those reported in the literature following separate administration of both metabolites to man. This study shows how such modeling can distinguish between metabolite formation and elimination processes and allow the determination of metabolite half-lives after administration of the precursor drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059280
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  • 128
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    Physiological pharmacokinetic modeling ofcis-dichlorodiammineplatinum(II) (DDP) in several species (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 131-155 
    Details
    ISSN: 1573-8744
    Keywords: pharmacokinetics ; physiological model ; cisplatin ; DDP ; cis-dichlorodiammineplatinum(II)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A physiological pharmacokinetic analysis ofcis-dichlorodiammineplatinum(II) (DDP) is presented for the rabbit, dog, and human. The results are compared to a previous analysis for the rat. DDP binds irreversibly to low-molecular weight nucleophiles and macromolecules to form mobile and fixed metabolites at rates which are tissue-specific. The rate constant for the formation of fixed metabolite in plasma, determined by in vitro incubation, ranges from 0.004 to 0.008 min−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01065258
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  • 129
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    Receptor-mediated model relating anticonvulsant effect to brain levels of camazepam in the presence of its active metabolites (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 309-321 
    Details
    ISSN: 1573-8744
    Keywords: camazepam ; temazepam ; oxazepam ; pharmacokinetics ; anticonvulsant effect ; radioreceptor assay ; rat ; mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In a displacement test using3H-diazepam as a radioligand, the in vitro affinities of metabolites of camazepam (CZ) for the benzodiazepine receptors were 1–50 times more potent than that of CZ. In contrast, only three metabolites (temazepam, oxazepam, and hydroxy CZ), as well as CZ itself, exhibited an in vivo affinity parallel to their ability to protect against pentylenetetrazole-induced clonic convulsion in rats. In addition, CZ and these active metabolites displaced the radioligand from their receptor sites in a concentration-dependent saturable manner, indicating the competitive bimolecular interaction of these molecules with their receptors. The percent anticonvulsant effect was a nonlinear, single-valued function of the in vivo percent displacement of specific3H-diazepam binding, independent of these displacers after i.v. dosing; this relationship could be approximated by the Hill equation. On the basis of these findings, a receptor-mediated model, including the Langmuir equation to describe the receptor binding-brain concentration relationship and the Hill equation to accommodate the anticonvulsant effect-receptor binding relationship, was constructed. This model was found to adequately relate the time course values of anticonvulsant effect and of brain levels of CZ and its active metabolites after oral administration. These results demonstrate that CZ and its active metabolites exert anticonvulsant effect by competitive binding to the benzodiazepine receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01106709
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    Effect of caffeine on ceftriaxone disposition and plasma protein binding in the rat (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 397-408 
    Details
    ISSN: 1573-8744
    Keywords: caffeine ; ceftriaxone ; plasma ; tissue ; pharmacokinetics ; compartment model ; protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Previous studies have shown that caffeine can affect drug kinetics by altering drug binding to plasma protein, drug absorption, or drug distribution. In this study, the effect of caffeine on the in vivoprotein binding and the disposition of ceftriaxone (a highly protein-bound cephalosporin) were investigated in the rat. Ceftriaxone 100mg/kg and caffeine 20mg/kg were i.v. injected via the tail vein and ceftriaxone in plasma, plasma filtrate, urine, feces, and tissues (brain, heart, kidney, liver, gut, lung, and muscle) was assayed by HPLC with UV detection. The fraction of free ceftriaxone in plasma ranged from 5.6 to 32.8% of total ceftriaxone (3–347 μg/ml) without caffeine and showed no alteration by caffeine. The total amount of ceftriaxone excreted in urine and feces was increased significantly (p〈0.05)from 13.1±1.8mg (mean±SD, 54.6% of total) to 15.3 ±1.1 mg (63.8% of total) by caffeine coadministration. The terminal half-life of ceftriaxone in plasma was shortened from 59 to 47 min, and the area under the plasma drug concentration-time curve (AUC)was reduced from 612 to 516 μg hr/ml Although the peak drug concentrations and the times of peak concentration of ceftriaxone in tissues were not altered by caffeine administration, the elimination of ceftriaxone was increased, as indicated by generally shorter half-lives (decreases ranged from 17.5% in liver to 34.2% in brain) and lower AUCvalues (from 9.0% in heart to 54.5% in brain). These results suggest that caffeine does not alter the protein binding of ceftriaxone, but enhances the elimination of ceftriaxone in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059199
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    Drug pharmacokinetics and the carbon dioxide breath test (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 29-49 
    Details
    ISSN: 1573-8744
    Keywords: carbon dioxide ; breath test ; pharmacokinetics ; metabolite ; extraction ratio ; aminopyrine ; caffeine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The interrelationship of the pharmacokinetics of a drug and the expiration of carbon dioxide formed as a metabolite have been studied. The pharmacokinetic characteristics of the drug that affect the usefulness of the carbon dioxide excretion as a measure of liver function were examined by means of computer simulations. The parent drug extraction ratio, fraction demethylated, volume of distribution, and absorption rate of an oral dosage form all contribute to the carbon dioxide breath test result. A drug that would be a useful substrate when the carbon dioxide breath test is used as a probe for changes in liver function should be at least 50% metabolized by demethylation, have a hepatic extraction ratio of 0.2–0.5, and be administered in a form that is rapidly absorbed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059282
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  • 132
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    Effects of the rate and composition of fluid replacement on the pharmacokinetics and pharmacodynamics of intravenous furosemide (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 495-509 
    Details
    ISSN: 1573-8744
    Keywords: furosemide ; pharmacokinetics ; pharmacodynamics ; fluid replacement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Effects of differences in the rate and composition of intravenous fluid replacement for urine loss on the pharmacokinetics and pharmacodynamics of furosemide were evaluated using the dog as a model animal. Each of six dogs received 8-hr constant intravenous infusion of 20 mg (15 mg used in one dog) of furosemide with 0% replacement (treatment I), 50% replacement (treatment II), and 100% replacement (treatment III) with lactated Ringer's solution, as well as with 100% replacement with 5% dextrose in water (treatment IV). Most pharmacokinetic parameters, such as plasma clearance, steady-state volume of distribution, mean residence time, and terminal half-life, were essentially the same in all four treatments. Renal clearances and urinary excretion rates of the drug in treatments II–IVwere essentially the same, but about 20% higher than those in treatment I.In spite of the similarities in kinetic properties, diuretic and/or natriuretic effects from furosemide were markedly different among the four treatments. For example, mean 10-hr urine outputs were 646, 1046, 3156, and 1976 ml and mean 10-hr sodium excretions were 87.0, 142, 383, and 97.2 mmole for treatments I–IV,respectively. Except for treatment III,diuresis and/or natriuresis were found to be time-dependent, generally decreasing with time until reaching a low plateau during later hours of infusion. The present findings also showed that (1)no fluid replacement and 100% replacement with 5% dextrose solution both produced the same degree of severe acute tolerance in natriuresis, indicating the insignificance of water compensation in tolerance development; (2)in treatment II,where neutral sodium balance was achieved, the development of acute tolerance in diuresis and natriuresis can mainly be attributed to negative water balance under this special condition; (3)at steady state the hourly diuresis and natriuresis could differ up to about ten times between treatments. Some implications for the kinetic/dynamic relationship or modeling, in the clinical use, and in the bioequivalence evaluation of dosage forms are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059657
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    Amiodarone pharmacokinetics. I. Acute dose-dependent disposition studies in rats (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 601-613 
    Details
    ISSN: 1573-8744
    Keywords: amiodarone ; pharmacokinetics ; dose-dependent ; rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Single intravenous bolus doses of amiodarone hydrochloride of 30, 60, 90 and 120 mg/kg were administered to male Sprague-Dawley rats to determine the effects of dose on amiodarone pharmacokinetics. Serial blood samples and total urine were collected over 48 hr and assayed for amiodarone and desethylamiodarone by HPLC. The blood amiodarone concentration-time curves for the four doses were best described by a triexponential equation with terminal half-lives (t 1/2γ ) ranging from 17 to 20 hr. Over the dose range studied, no changes in γ, t 1/2γ , or central compartment volume (Vc=1.2–1.4 L/kg) were observed. On the other hand, reductions in amiodarone clearance (CL and steady-state volume of distribution (V ss of 44% (17.7 to 10.0 ml/min per kg) and 50% (16.4 to 8.2 L/kg), respectively, were noted as the dose of amiodarone increased. The conversion of amiodarone to desethylamiodarone (fm was dose-independent and amounted to approximately 10% of each amiodarone dose. No amiodarone or desethylamiodarone was detected in the urine of any of the treated animals. The blood-to-plasma concentration ratio of amiodarone was concentration-independent and therefore did not account for the dose-dependent changes in Vss and CL observed. The data suggested that the dose-dependent changes noted were due to an alteration in the volume (s) of the peripheral tissue compartment(s).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01067966
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    Analysis of pethidine disposition in the pregnant rat by means of a physiological flow model (1986)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 14 (1986), S. 381-395 
    Details
    ISSN: 1573-8744
    Keywords: pethidine ; rat ; physiological flow model ; pharmacokinetics ; pregnancy ; scale up ; opiates, GC-MS analytical method ; simulations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The disposition of pethidine (meperidine) in the pregnant rat is described by means of a physiological flow model. The model includes arterial and venous blood, brain, fat, fetal, hepatic, intestinal, muscular, pulmonar, and renal tissues. The concentration-time profiles of pethidine calculated by the model are consistent with experimental data, except for the brain and renal tissues, where the model predicts initially higher concentrations. Simulations are carried out to further explore the contribution from different organs on the kinetics in blood and tissues. The tissue-to-blood partition coefficients vary over a range from 5 to 316, where fat has the lowest and liver the highest after a correction is made due to hepatic extraction. Rapid uptake occurs into highly perfused organs such as brain, kidneys, liver, and lungs, followed by fetus, intestines, muscle, and fat. Data indicate no marked membrane resistance to pethidine of the investigated organs, except for fetal tissues, but rather a perfusion-limited uptake. Simulations suggest that muscles and adipose tissue play an important role in the rat, becoming the major reservoir of drug during the intermediate and terminal elimination phase, respectively. Volume of distribution and the biological half-life agree with reported findings. Pethidine is subject to a high systemic blood clearance, which exceeds the total hepatic blood flow in the rat. No degradation of pethidine is found in blood, and therefore a pulmonary expression for pethidine clearance is added as a potential source of pethidine elimination. The elimination of pethidine after a single i.v. bolus dose is found to be dependent on simulated changes in cardiac output and hepatic blood flow. A simulation is performed with the scaled model to mimic the human concentration-time profiles in maternal blood and brain tissues and fetal tissue during repetitive doses of pethidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059198
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    Saturable Processes Affecting Renal Clearance of Cefixime in Dogs (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 150-155 
    Details
    ISSN: 1573-904X
    Keywords: renal clearance ; cephalosporin ; cefixime ; tubular reabsorption ; saturable protein binding ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics of cefixime, a new orally active cephalosporin, was studied after an intravenous dose of 50 mg/kg to four beagle dogs. Cefixime was shown to exhibit concentration dependent serum protein binding and saturable tubular reabsorption. The drug was excreted mainly in the urine, the net result of glomerular filtration and saturable tubular reabsorption. The experimental results were analyzed by model independent pharmacokinetic equations and with theoretical models describing renal clearance. Modification of the models, based on observed data, was proposed. The experimental methods employed and the pharmacokinetic approach offered in this study can be applied to drugs that exhibit concentration dependent protein binding and saturable renal elimination processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016309923717
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    The Effect of Amiodarone on Theophylline Pharmacokinetics in the Rat (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 167-169 
    Details
    ISSN: 1573-904X
    Keywords: amiodarone ; theophylline ; pharmacokinetics ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Amiodarone is an investigational antiarrhythmic agent which has been implicated in reducing the activity of the hepatic mixed-function oxidase system. To evaluate this effect further, two groups of six male Sprague–Dawley rats each received theophylline (6 mg/kg, iv) preceded by either normal saline or amiodarone HC1 (100 mg/kg, iv). Blood samples were obtained serially for a period of 6 hr and the sera were assayed for theophylline by high-pressure liquid chromatography (HPLC). In rats pretreated with amiodarone, a significant 45% reduction in the mean (± SD) systemic clearance [0.057 (0.010) vs 0.031 (0.004) liter/hr/kg, P 〈 0.001] and a greater than 100% increase in the mean elimination half-life [2.03 (0.46) vs 4.29 (0.71) hr, P 〈 0.001] of theophylline were observed. These data demonstrate an acute inhibitory effect of amiodarone on the hepatic microsomal enzyme system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016366008696
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  • 137
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    Engineering Targeted In Vivo Drug Delivery. I. The Physiological and Physicochemical Principles Governing Opportunities and Limitations (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 333-344 
    Details
    ISSN: 1573-904X
    Keywords: drug delivery, targeted ; prodrugs ; pharmacokinetics ; pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A physiologically based model is presented to aid prediction of the pharmacological benefits to be derived from the administration of a drug as a targeted drug–carrier combination. An improvement in the therapeutic index and an increase in the therapeutic availability are the primary benefits sought. A measure of the former is obtained from the value of the drug targeting index, a newly derived parameter. Both the drug targeting index and the therapeutic availability are directly calculable. The minimum information needed for approximating both parameters is the candidate drug's total-body clearance and some knowledge of the target site's anatomy and blood flow. Drugs with high total-body clearance values that are known to act at target tissues having effective blood flows that are small relative to the blood flow to the normal eliminating organs will benefit most from combination with an efficient, targeted carrier. Direct elimination of the drug at the target site or at the tissue where toxicity originates dramatically improves the drug targeting index value. The fraction of drug actually released from the carrier at both target and nontarget sites can radically affect index values. In some cases a 1% change in the fraction of the dose delivered to the target can result in a 50% change in the drug targeting index value. It is argued that most drugs already developed have a low potential to benefit from combination with a drug carrier. The approach allows one to distinguish clearly those drugs that can benefit from combination with targeted in vivo drug carriers from those drugs that cannot.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016332023234
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  • 138
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    Influence of Malnutrition on the Disposition of Metronidazole in Rats (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 352-355 
    Details
    ISSN: 1573-904X
    Keywords: malnutrition ; metronidazole ; pharmacokinetics ; rats ; metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The influence of dietary protein deficiency on the disposition of metronidazole and its two major metabolites was examined in male Sprague–Dawley rats fed for 4 weeks on a 23% (control-) or a 5% (low-) protein diet ad libitum. Following an intravenous bolus dose of 10 mg/kg metronidazole hydrochloride, blood samples were obtained serially for a period of 24 hr after drug administration. Serum concentration–time data were analyzed by nonlinear least-squares regression, as well as noncompartmental techniques. The average mean residence time (MRT) was significantly prolonged by 48%, while the systemic clearance (Cl) was decreased by 42% in the protein-deficient rats. Since there was no alteration in the apparent steady-state volume of distribution (V ss), the mean harmonic half-life was increased from 2.9 to 5.0 hr in the protein-deficient rats. Although the percentage of metronidazole recovered as total drug in the urine over 24 hr was not significantly different between the two groups of animals, rats on a low-protein diet excreted a significantly smaller percentage of the administered dose as unchanged metronidazole (mean ± SD, 24.6 ± 3.8 vs 36.5 ± 12%) and a larger percentage (16.7 ± 2.6 vs 8.3 ± 1.8%) as the hydroxylated metabolite. No significant difference in the partial metabolic clearance of the hydroxylated metabolite of metronidazole was seen between the two groups of animals; however, there was a significant decrease in the renal clearance of metronidazole (1.45 ± 0.68 vs 0.55 ± 0.06 ml/min/kg) in the rats fed a low-protein diet. We conclude that the decreased clearance of metronidazole in protein deficiency is a result primarily of the decreased glomerular filtration rate, decreased biliary excretion, and/or increased net tubular reabsorption of metronidazole.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016433724142
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    Bioavailability of Propranolol After Oral, Sublingual, and Intranasal Administration (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 108-111 
    Details
    ISSN: 1573-904X
    Keywords: propranolol ; intranasal ; sublingual ; absorption ; bioavailability ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The bioavailability of propranolol was compared after oral, sublingual, and intranasal administration in eight healthy male volunteers. Relative to the bioavailability after intranasal (in) administration, which was previously shown to be nearly complete (F relin = 100%), the sublingual (sl) administration of a standard 10-mg tablet gave a bioavailability of F relsl = 63 ± 22%, while the oral (or) administration yielded only F relor = 25 ± 8%. The serum concentration–time curves of propranolol after sublingual administration resembled those of a sustained-release preparation. This sustained-release phenomenon after the sublingual route is reflected in the mean residence times (MRTs) of propranolol in the body (MRTor = 5.7 ± 1.3 hr, MRTsl - 6.4 ± 1.3 hr, MRTin = 4.6 ± 1.0 hr; mean ± SD; N = 8). MRTs after sublingual administration were significantly longer than after the oral and the intranasal doses (P 〈 0.05 and P 〈 0.002, respectively).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016345504153
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  • 140
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    Pharmacokinetics and Reversible Biotransformation of Sulfinpyrazone and Its Metabolites in Rabbits. I. Single-Dose Study (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 173-177 
    Details
    ISSN: 1573-904X
    Keywords: sulfinpyrazone ; pharmacokinetics ; reversible metabolism ; single dose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In rabbits receiving sulfmpyrazone (SO) and the sulfide metabolite (S) in four separate experiments, the biotransformation of SO into S was found to be reversible, which resulted in approximately parallel terminal disposition profiles for the three major substances in plasma, i.e., SO, S, and the p-OH-sulfide (OH-S). However, differences in disposition kinetics were observed between the intravenous and the peroral administration. The formation of OH-S was independent of both the administered compound and the administration route. The results obtained in the present studies, the previously documented enterohepatic recirculation, and the formation of S by hindgut flora may have implications for studies on sulfinpyrazone, which has been used as an antithrombotic agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016370209604
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  • 141
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    Pharmacokinetics and Reversible Biotransformation of Sulfinpyrazone and Its Metabolites in Rabbits. II. Multiple-Dose Study (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 178-183 
    Details
    ISSN: 1573-904X
    Keywords: sulfinpyrazone ; pharmacokinetics ; reversible metabolism ; multiple dose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In crossover studies rabbits were given sulfmpyrazone (SO) and its sulfide metabolite (S) perorally once daily (10 mg/kg) for 5 days. Comparison of the pharmacokinetic parameters obtained after the first and the fifth dose indicates that repeated dosing does not alter disposition kinetics of both SO and S, except that in dosing with S the observed terminal half-life for S is significantly reduced, from 4.59 ± 0.55 to 2.86 ± 0.6 hr (SD). In other studies rabbits were given higher single doses (15, 25, and 50 mg/kg) perorally and comparison was made between these dose sizes and the first dose (10 mg/kg) of multiple administration with S. Some kinetic parameters tended to be altered in a nonlinear fashion, and greater intersubject variations were observed because of the dose increase, while oxidation to SO or p-hydroxylation to OH-S from S was not significantly altered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016322326443
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  • 142
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    Pharmacoclinical data on high dose medroxyprogesterone acetate in advanced breast cancer (1986)
    Springer
    Breast cancer research and treatment 8 (1986), S. 161-163 
    Details
    ISSN: 1573-7217
    Keywords: medroxyprogesterone acetate ; pharmacokinetics ; response ; toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01807705
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  • 143
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    A different view of the assumed stress hybrid method (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 11-16 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A somewhat unconventional, yet simple, derivation of the assumed stress hybrid formulation is presented in which its relationship with displacement and stress-based finite element models is demonstrated. This gives insight into the hybrid method and shows that it represents a least energy fit of an equilibrium stress field to a displacement model strain field. By this means the attributes of both fields may be exploited in extending the analysis scope of hybrid models.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220103
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  • 144
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    A new nine node degenerated shell element with enhanced membrane and shear interpolation (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 73-92 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A new nine node degenerated shell element is presented in this paper. In the formulation of the new element, an enhanced interpolation of the transverse shear strains in the natural co-ordinate system is used to overcome the shear locking problem, and an enhanced interpolation of the membrane strains in the local Cartesian co-ordinate system is applied to avoid membrane locking behaviour. It is shown that the resulting element has the requisite number of zero eigenvalues and associated rigid body modes. The element does not exhibit membrane or shear locking for large span/thickness ratios. To illustrate the good performance of the new element some examples are presented including comparisons with the behaviour of the selectively integrated Lagrangian degenerated shell elements.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220107
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  • 145
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    A study on the linear elastic stability of Mindlin plates (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 117-132 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The debate on the performance of Lagrangian and Serendipity elements in Mindlin's plate theory has been going on for quite some time. Limited published results for static and vibration analysis based on exact integration demonstrated a drastic deterioration in accuracy as the thickness of the plate decreases, and reduced/selective integration schemes have been suggested to improve their performance. Appreciable improvement for Lagrangian elements has been recorded, but it is only marginal for the Serendipity elements. On the strength of such observations one would then be tempted to rule out the exact integration schemes and Serendipity elements.In this paper, the above problem is reviewed for stability analysis of plates. Two elements are chosen from each family, one representing the higher order and the other the lower order element. Contrary to published results, all elements can attain very accurate solutions independent of the integration schemes for a sufficiently restrained plate, although in general the Serendipity elements will require a more refined mesh than the Lagrangian ones. However, for loosely restrained plates, the solution failed when integration is performed by reduced/selective schemes. The failure marks the limitation of the reduced/selective schemes which have somehow introduced spurious modes into the system, but on the other hand it is ironical that these spurious modes in fact contribute to the improvement of performance of the restrained cases. Therefore, one can equally improve the Serendipity elements by a selective scheme which can introduce additional zero modes. A scheme based on (5 × 5) integration points for flexural stiffness and (3 × 3) integration points for shear stiffness improved the 17SE (Serendipity elements) remarkably. However, because of the lack of bounds in most cases, the use of reduced/selected schemes is still not recommended. Finally, this paper also proposed an approximate formulation of the geometric stiffness matrices to replace the full formulation. Such an approximate formulation reduces the number of variables considerably in the eigenvalue search and can still give reasonably accurate results for thin plates with a/t 〉 15.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620220109
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  • 146
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    Ultimate load behaviour of reinforced concrete plates and shells under dynamic transient loading (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 189-208 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper considers a layered thick shell finite element procedure for determining the dynamic transient nonlinear response of plates and shells. The degenerated three-dimensional isoparametric shell element with independent rotational and translational degrees-of-freedom is employed and a layered formulation is adopted to represent the steel reinforcement and to simulate progressive concrete cracking through the thickness. The dynamic yielding function is assumed to be a function of the current strain rate, in addition to being total plastic strain or work dependent. The concrete model also simulates both compressive crushing and tensile cracking behaviours and an implicit Newmark algorithm is employed for time integration of the equations of motion. Several numerical examples are presented for both slab and shell structures and the results obtained compared with those from other sources wherever available.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220114
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  • 147
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    Program structure and architecture for a finite element machine (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 241-248 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Superproblems in finite elements require either general-purpose or special-purpose computing machines whose capabilities are very much greater than those currently existing. The advantage of the latter type of machine is that it can be highly optimized for the particular class of problem for which it is designed and can, in principle, for a given generation of hardware, be designed to operate at a higher speed than a corresponding general-purpose computer. The Parallel Finite Element Machine (PARFEM) investigated at the University of Calgary has an architecture based on the finite element computational algorithms and employs a combination of parallel and vector processing. The overall architecture and program structure is described and the major design considerations outlined.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220118
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    Preface (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. i 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220202
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  • 149
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    An inverse method for the design of axisymmetric optimal diffusers (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 377-394 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An inverse inviscid-boundary-layer interaction scheme is presented for the optimal design of axisymmetric ducts for subsonic, rotational flows. Distribution of the shape factor H on the duct wall, giving minimum total pressure loss and maximum static pressure rise, is used as boundary condition for the inverse integral boundary-layer solution, to obtain the velocity and displacement thickness distributions on the wall. Vector addition of the inviscid core radius, derived from the solution of the inverse inviscid flow equations, and the displacement thickness produces the desired duct shape.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220207
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  • 150
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    A natural formulation for the solution of two-dimensional or axisymmetric inverse problems (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 451-463 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220211
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  • 151
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    Computer simulation of crash phenomena (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 497-519 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The paper summarizes preliminary work on crash analysis25-27 performed on an extended finite element model as provided by the nonlinear LARSTRAN program package at ICA. The essential methodology is evolved along the natural finite element approach. Also overviewed are solution techniques for the nonlinear equations of motion. The application of a simple folding mechanism is indicated and crashworthiness computations of car structures are described.
    Additional Material: 23 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220303
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  • 152
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    Shallow water problems: A general explicit formulation (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 547-574 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: We present in this paper a general formulation for shallow water equations which is capable of solving problems of induced harbour oscillation, tidal flow, tsunami propagation, dispersion of pollutant, etc.The shallow water equations are written in a novel fully conservative form. The solution algorithm is based on an explicit time integration procedure which exploits the conservative properties of the governing equations and incorporates accurate treatment of convective terms without introduction of artificial damping. Its accuracy and low cost of computation make it attractive vis-à-vis existing procedures.
    Additional Material: 14 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620220305
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  • 153
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    Thickness effects of CCT specimens (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 623-635 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: First, the three-dimensional elasto-plastic analyses of 1CT and 18 mm thick CCT specimens are carried out by using the finite element method, and the thickness effects of both specimens are studied. In elastic states, there is no significant difference between the CT and CCT specimen in the distribution of the J-integral along the straight or curved crack front. However, in elasto-plastic states, quite the contrary tendency is obtained in the distributions of J x and COD along the curved crack front for both specimens. Secondly, elasto-plastic analyses are carried out for CCT specimens of four kinds of thickness (B = 200, 18, 6 and 4 mm). The distributions of the J-integral along the crack front are obtained and compared. Finally, the availability of the JR value is examined, which is evaluated from the load versus displacement curve by using Rice's formula.
    Additional Material: 22 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620220308
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    The patch test - a condition for assessing FEM convergence (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 39-62 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper discusses various forms of the Irons patch test and shows again that its satisfaction is a necessary convergence condition being equivalent to consistency, Further, it is shown that the test can be applied for verification of stability requirements, thus providing also a sufficient condition of convergence. The patch test is useful in testing the order of asymptotic convergence and the satisfaction of the test gives a guide for development of certain incompatible element forms.
    Additional Material: 13 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620220105
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    TRUNC for shells - an element possibly to the taste of Bruce Irons (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 93-115 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In his delightful and original textbook,18 Bruce Irons introduces the chapter of plate bending with the remark ‘History of disasters, but the pioneering days are past’. This is certainly true. On the other hand, we learn in the same context from Irons: ‘We believe that the world has not yet exhausted the older formulations.’ In this paper we present a review of theoretical aspects of the plate-bending triangle TRUNC (Reference 4), together with extensive tests in linear statics, dynamics, buckling and nonlinear large deformations both for plates and shells. The unconventional TRUNC model is based on the patch test, which was originated by Irons.1 In spite of its limited theoretical foundation, the performance of this element on a fairly broad field of applications appears at least from the practical point of view very satisfactory.
    Additional Material: 23 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620220108
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    Relations between incompatible displacement model and hybrid stress model (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 173-181 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An examination of the variational formulations confirms the similarity between the incompatible displacement model and the assumed stress hybrid model that was pointed out by Irons in 1972. But the basic differences between the two are also identified. For 8-node solid elements the assumed stress terms obtained through a rational procedure also agree with those deduced by Irons purely from his physical insight.
    Additional Material: 2 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620220112
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    A study of the efficiency of iterative methods for linear problems in structural mechanics (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 209-218 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The efficiency of iterative methods in linear structural mechanics is studied. The efficiency concerns the calculation time, the numerical accuracy and the core storage needed. We state that iterative methods are effective in connection with hierarchical improvement of a primary approximation. Three iterative methods are studied: the conjugate gradient method preconditioned by a modified incomplete factorization matrix, the same method preconditioned by a matrix obtained from natural factors on elemental level, and a Jacobi integration preconditioned by viscous relaxation split in an element-by-element way. We make comparisons with direct methods, Gaussian elimination and factorization by use of natural factors.
    Additional Material: 5 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620220115
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    Optimization in computer aided design, Ed. J. S. Gero, (Proceedings of I.F.I.P. Conference, Lyon, 1983), North Holland, Elsevier Science Publishers, 1985 (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 169-169 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230113
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    Conference diary (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 170-171 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230115
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  • 160
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    Differentiating matrices for arbitrarily spaced grid points (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 209-218 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Differentiating matrices allow the numerical differentiation of functions defined at points of a discrete grid. Previous derivations of these matrices have been restricted to grids with uniformly spaced points, and the resulting derivative approximations have lacked precision, especially at endpoints. The present work derives differentiating matrices on grids with arbitrarily spaced points. It is shown that high accuracy can be achieved through use of differentiating matrices on non-uniform grids through the expedient of including ‘near- boundary’ points. Use of the differentiating matrix as an operator in the solution of problems involving ordinary differential equations is also considered.
    Additional Material: 1 Tab.
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    URL: http://dx.doi.org/10.1002/nme.1620230205
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    Conference diary (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 350-351 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230216
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    A total Lagrangian formulation for the geometrically nonlinear analysis of structures using finite elements. Part II: Arches, frames and axisymmetric shells (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 253-274 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230209
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  • 163
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    Structural optimization: A new dual method using mixed variables (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 409-428 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A new and powerful mathematical programming method is described, which is capable of solving a broad class of structural optimization problems. The method employs mixed direct/reciprocal design variables in order to get conservative, first-order approximations to the objective function and to the constraints. By this approach the primary optimization problem is replaced with a sequence of explicit subproblems. Each subproblem being convex and separable, it can be efficiently solved by using a dual formulation. An attractive feature of the new method lies in its inherent tendency to generate a sequence of steadily improving feasible designs. Examples of application to real-life aerospace structures are offered to demonstrate the power and generality of the approach presented.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230307
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    Conference diary (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 523-524 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230314
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    Masthead (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986) 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230401
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  • 166
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    Nozzle design using an iterative Dirichlet approach (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 481-494 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220213
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  • 167
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    Preface (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. i 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220302
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  • 168
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    Hydrostatic loading and stability analysis of structures with large displacements (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 575-595 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A method for the computation of hydrostatic forces on cable, truss, beam, plate and shell type structures is presented. A general large displacement formulation is assumed which allows for displacements and rotations of unlimited size. Equilibrating forces for nodal points as well as incremental force-displacement relationships are given. Various ways of making the geometric load matrix symmetric for incremental analysis is discussed. Alternative strategies for the incremental-iterative solution is also treated. A method for the determination of the hydrostatic stability of floating structures is suggested. Metacentres and centres of buoyancy for rotations about principal axes in the water plane are automatically computed. The paper presents three examples of applications: a pipe which is partially submerged, a full overturning of a floating space frame and, finally, a hydrostatic stability analysis of a ship.
    Additional Material: 12 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620220306
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  • 169
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    A new triangular discrete Kirchhoff plate/shell element (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 453-470 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: We present a new 6-node triangular bending element (called DKTP) based on a discrete Kirchhoff model. A corresponding new flat-shell element, DLTP, having quadratic variation of in-plane displacement is also presented. This element has 6 degrees-of-freedom (u, v, w, θx, θy, θz) at each corner node and 3 degrees-of-freedom (u, v, w) at each mid-side node. Detailed numerical experimentation is presented to demonstrate the efficiency and reliability of these elements.
    Additional Material: 13 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230310
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  • 170
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    Finite layer analysis of layered elastic materials using a flexibility approach. Part 2 - Circular and rectangular loadings (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 959-978 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The finite layer techniques introduced in Part 1 of this paper are extended to allow the analysis of circular or general loadings applied to horizontally layered anisotropic materials. The analysis is considerably simplified through the use of Hankel transforms (circular loadings) and double Fourier transformations (general loadings).Once again an exact flexibility matrix is found for each finite layer, and it is shown that this flexibility matrix has precisely the same form whether the loading is a strip, circular or general loading. The flexibility matrix has the advantage of not becoming singular for incompressible materials as is the case for the stiffness matrices used in a conventional finite strip analysis.Examples are given of the behaviour of circular and general (rectangular) loadings applied to multilayered anisotropic materials. It is also shown by means of an example, that the method is extremely useful for analysis of problems involving incompressible materials.
    Additional Material: 6 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230515
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  • 171
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    Advanced boundary element analysis of two- and three-dimensional problems of elasto-plasticity (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 985-1002 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An advanced formulation of the boundary element method has been developed for inelastic analysis based on an initial stress approach. The iterative solution algorithm makes use of an accelerated initial stress approach in which the past history of initial stresses are used to obtain an initial estimate for the current increment. In the present analysis the geometry and functions are represented by higher order (quadratic) shape functions to model complex geometries and rapid functional variations accurately. The methods of numerical integration of the kernels, particularly the singular type, are substantially improved by devising suitable automatic sub-segmentation routines that incorporate the recent developments in mapping procedures. The formulations have been implemented for two-dimensional plane stress, plane strain and three-dimensional elasto-plasticity problems.
    Additional Material: 12 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230602
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    Hybrid finite difference/finite element solution method development for non-linear superconducting magnet and electrical circuit breakdown transient analysis (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1003-1022 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The problem of non-linear superconducting magnet and electrical protection circuit system transients is formulated. To enable studying the effects of coil normalization transients, coil distortion (due to imbalanced magnetic forces), internal coil arcs and shorts, and other normal and off-normal circuit element responses, the following capabilities are included: temporal, voltage and current-dependent voltage sources, current sources, resistors, capacitors and inductors. The concept of self-mutual inductance, and the form of the associated inductance matrix, is discussed for internally shorted coils. This is a Kirchhoff's voltage loop law and Kirchhoff's current node law formulation. The non-linear integrodifferential equation set is solved via a unique hybrid finite difference/integral finite element technique.
    Additional Material: 9 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230603
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    Incomplete factorization for finite element methods (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1101-1109 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An incomplete factorization iterative scheme with ORTHOMIN acceleration is evaluated for three-dimensional finite element applications. Both heat conduction and combined heat and fluid flow are investigated. Computational efficiency is investigated for both linear (8 node) and quadratic (27 node) elements as well as for various degrees of LU Decomposition. The factorization schemes worked well with both types of elements, and a variable factorization scheme, which distributes the level of factorization, performed well on difficult heat and fluid flow problems.
    Additional Material: 5 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230608
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  • 174
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    Boundary value techniques for finite element solutions of the diffusion-convection equation (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1145-1159 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In this paper, the formulation of six-point and nine-point finite element equations for the solution of the diffusion-convection equation is presented. The six-point equation requires the solution of a tridiagonal system of equations and the nine-point centred equation is treated as a solution of a boundary value problem which leads to a large linear system of equations.Some numerical experiments are presented and the comparison with existing methods is included.
    Additional Material: 3 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230611
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    Developments in boundary element methods 3, P. K. Banerjee and S. Mukherjee (eds), Elsevier Applied Science Publishers, London and New York, 1984. No. of pages: 313 (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1195-1196 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230614
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  • 176
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    A field-consistent two-noded curved axisymmetric shell element (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1245-1261 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The efficiency of a field-consistent two-noded linear curved axisymmetric shear-flexible shell element is shown to be due to the removal of both shear and membrane locking. Typical applications illustrate how the field-consistent representation dramatically improves performance, and allows greater flexibility in tailoring element design to satisfy specific problem needs.
    Additional Material: 14 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230705
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  • 177
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    Dynamic optimization of framed structures with variable layout (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1273-1294 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The paper presents a solution to the problem of dynamic optimization of framed structures for which the design variables are not only the sizes of the members but also the positions of the joints. The optimal design obtained is the least weight design which satisfies a specific frequency requirement plus upper and lower bounds on the design variables. The design algorithm is an iterative solution of the Kuhn-Tucker optimality criterion. The procedure is to modify an initial design to first obtain the desired fundamental frequency and then, while this frequency is held constant, to minimize the weight.The most important features of the algorithm are (a) a small number of design iterations is needed to reach an optimal or near-optimal design, (b) structural elements with a wide variety of size-stiffness may be used.The design procedure is illustrated with some numerical examples. The results show that the method is rapidly convergent and the optimized configurations are determined in a small number of redesign cycles. The procedure has been completely automated in a computer program on the HP 45 desk-top computer.
    Additional Material: 12 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230707
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  • 178
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    Reduction method for the non-linear analysis of symmetric anisotropic panels (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1329-1341 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Reduction method and computational procedures are presented for reducing the size of the analysis model and the number of degrees of freedom used in predicting the non-linear response of symmetric anisotropic panels. The two key elements of the method are (a) operator splitting, or decomposition of the characteristic arrays of the finite element model into sums of orthotropic and non-orthotropic contributions, (b) application of a reduction method through the successive use of the finite element method and the classical Rayleigh-Ritz technique. The finite element method is first used to generate a small number of global approximation vectors (or modes). Then the amplitudes of these modes are computed by using the classical Rayleigh-Ritz technique.The global approximation vectors are selected to be those commonly used in single (or multiple) parameter perturbation techniques, namely a non-linear solution corresponding to zero non-orthotropic arrays and a number of its derivatives with respect to an anisotropic tracing parameter (and possibly, to a load or arc-length parameter in the solution space). The size of the analysis model used in generating the global approximation vectors is identical to that of the corresponding orthotropic structure.The effectiveness of the proposed reduction method is demonstrated by means of a numerical example, and its potential for solving quasi-symmetric non-linear problems of anisotropic panels is discussed.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230710
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  • 179
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    Spatial discretization of hyperbolic equations with periodic solutions (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1395-1406 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: We investigate the Cauchy problem for hyperbolic equations for which the frequencies of the main Fourier components in the solution are located in a given frequency interval. Difference formulae for the spatial derivatives are constructed that are tuned to the given intervals of frequencies. Numerical examples illustrating these special discretizations are given both for linear and non-linear problems.
    Additional Material: 10 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230802
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    Numerical solution of constrained non-linear algebraic equations (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1455-1481 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The numerical solution of n non-linear algebraic equations with n unknowns, when any or all of the variables are subjected to constraints, is discussed. Distinction is made between physical and absolute constraints. It is shown, using a set of test problems, that solution of constrained equations does require a special approach. It is found that the step length restricted Newton's method performs best for problems with absolute constraints. Physical constraints can be best handled using a continuation method or penalty functions.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230805
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    A restricted hybrid stress formulation based on a direct finite element method (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1495-1508 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A direct method, which uses stress and displacement modes obtained from the governing equations of a problem, is adopted for finite element formulation. It is shown that this method actually leads to a restricted hybrid stress formulation if the displacement modes are changed to ensure symmetry of the stiffness matrix. Through this direct method, however, the problem of selecting the appropriate number of stress modes in the regular hybrid stress model is bypassed. Only the minimum number of modes that are compatible with the number of nodal degrees-of-freedom of an element is needed in the formulation. Using more modes only leads to a combination of stress modes, and will not improve the order of performance of the element. It is shown through numerical examples that the restricted hybrid stress formulation leads to well-balanced elements.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230807
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    Dynamic response of rigid strip-foundations by a time-domain boundary element method (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1547-1565 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The dynamic response of rigid strip-foundations placed on or embedded in a homogeneous, isotropic, linear elastic half-space under conditions of plane strain to either external forces or obliquely incident seismic waves of arbitrary time variation is numerically obtained. The above mixed boundary-value problems are treated by the time domain boundary element method which is used in a step-by-step timewise fashion to provide the foundation response to a rectangular impulse. Numerical examples are presented in detail to demonstrate the use and importance of the proposed method. The method appears to be more advantageous than frequency domain techniques, because it provides the transient foundation response in a natural and direct way and can form the basis for extension to the non-linear case.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230810
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    Announcements (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1582-1582 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230814
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  • 184
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    A new efficient approach to the formulation of mixed finite element models for structural analysis (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1629-1641 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A new mixed finite element formulation is developed based on the Hellinger-Reissner principle with independent strain. By dividing the assumed strain into its lower order and higher order parts, the new formulation can be made much more efficient than the conventional mixed formulation. In addition the present new approach provides an alternative way of introducing a stabilization matrix to suppress undesirable kinematic modes.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230905
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    Minimum weight design of cylindrical water tanks (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1679-1691 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The paper deals with the minimum weight design of cylindrical water tanks. The design is to conform to BS5337. The design procedure used is a combination of the finite element analysis of structures and a numerical method of optimization. In the design, the internal radius and the height of the tank are fixed and the variation of wall thickness is treated as the unknown of the design. Only piecewise linear variations of thickness are considered. Results of some examples are presented and discussed.
    Additional Material: 7 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230908
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  • 186
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    Finite element method for non-linear forced vibrations of circular plates (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1715-1726 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Geometric non-linearities for large amplitude free and forced vibrations of circular plates are investigated. In-plane displacement and in-plane inertia are included in the formulation. The finite element method is used. An harmonic force matrix for non-linear forced vibration analysis is introduced and derived. Various out-of-plane and in-plane boundary conditions are considered. The relations of amplitude and frequency ratio for different boundary conditions and various load conditions are presented.
    Additional Material: 6 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620230911
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  • 187
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    Conforming versus non-conforming boundary elements in three-dimensional elastostatics (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1885-1904 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In this work, we present a critical comparison of two basic ways of implementing the boundary element method in three-dimensional elastostatics. The first way is by using non-conforming elements, i.e. elements which have the collocation nodes removed from their perimeter. The number of nodes used for the collocation of the boundary tractions and displacements need not coincide with the number of nodes placed along the perimeter of the element for the purpose of describing the geometry. The second way is by placing the collocation nodes along the perimeter of the element, usually in coincidence with the geometry nodes. Thus, interelement continuity of the displacements is obtained. The basic reasons for the use of non-conforming elements in the boundary element method are twofold. First, simplification in the assembly and solution of the system equations and, secondly, easy computation of the ‘free’ and Cauchy principal value terms appearing in the integral equations. The state of the art in the boundary element method, however, has advanced in the last decade to the point where both of the aforementioned reasons are no longer problematic. As will be shown in what follows, conforming elements are able to produce more accurate results than non-conforming ones with substantial economy in the final size of the system equations.
    Additional Material: 8 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620231008
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    Derivation of Lagrangian and Hermitian shape functions for quadrilateral elements (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1939-1958 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper introduces a general theory for the derivation of the shape functions for the quadrilateral family of finite elements. The first section deals with the Lagrangian shape functions for the cases of uniform and boundary-described elements. Two basic procedures are introduced; the first by linear combinations of side-interpolations and the second by superposition. The remainder of the paper introduces a theory for the general uniform Hermitian element of any order. Details for quadrilateral elements, with first order derivatives are explained. All of the shape functions presented here were derived in the interval [0,1].The shape functions, developed by such an engineering approach, have been used successfully in the ABSEA Finite Element System of Cranfield Institute of Technology.
    Additional Material: 10 Ill.
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    URL: http://dx.doi.org/10.1002/nme.1620231011
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  • 189
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    Announcements (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 1971-1972 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620231014
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    Masthead (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986) 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620231201
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    Announcement (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. I 
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    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620231202
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  • 192
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    Masthead (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986) 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220101
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  • 193
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    The patch test for elements (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 63-71 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The main purpose of this paper is to emphasize the necessity of convergence tests in general and the patch test in particular. Following a brief introduction, the patch test is described with examples. This, it is hoped, will help to remove any lingering misunderstanding of this very useful convergence test. Some positive contributions of the test in the formulation and improvement of elements are also discussed.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220106
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  • 194
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    An assessment of the semiloof shell element (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 133-151 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The semiloof shell element is the final product of years of research by Professor Irons and his colleagues, during which period the three-dimensional quadratic displacement isoparametric elements were successively modified into Ahmad thick shells, then eventually, using discrete Kirchhoff hypotheses, into the thin semiloof shells. The retention of curved sides and midside nodes retains the familiar appearance of the two- and three-dimensional isoparametric families, which enables ease of use with existing pre- and post-processing facilities. The element has been widely adapted and used frequently for elastic analyses of wide-ranging structures. It has also been developed for nonlinear geometric and material behaviour. However, despite the unparalleled generality in performance of this element, some unresolved problem areas still exist, particularly with use of reduced integrating rules. Such problems are highlighted in the paper and rectified where possible. A variety of problems are described to illustrate the above points and other interesting features, such as the treatment of thermal loading, and to emphasize the importance of this contribution to finite element technology by Professor Irons.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220110
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  • 195
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    Bruce Irons: A non-conforming engineering scientist to be remembered and rediscovered (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 1-10 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220102
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  • 196
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    Implicit modelling and mesh refinement for complex structures (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 17-38 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: When analysing complex structures it is rarely feasible to represent explicitly all the structural features which may contribute significantly to local or global structural performance. This paper presents a variety of methods for representing features which are below the economic analysis scale. Two approaches are described - referred to as implicit stiffness calculation and implicit mesh refinement. The former is essentially approximate and uses relatively simple formulae and computations. The latter involves quite extensive subsidiary calculation, but can lead to numerically exact simulation of fine mesh behaviour in so far as it affects neighbouring structure. Stiffness equivalence principles are stated and a number of computation schemes are presented and illustrated with simple two-dimensional examples.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220104
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  • 197
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    A study of the influence of hierarchical nodes on the performance of selected parametric elements (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 153-171 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A number of programs have been developed and tested to enable the routine addition of elements with internal nodes into most finite element packages. A subsequent examination was carried out to assess the effect of those nodes on (a) the accuracy of the displacements and stresses using parametric elements with varying formulation complexities, and (b) the possible additional cost in processing, owing to adequacy of representation. It was found in general that, by including the internal nodes, the representation of both the displacement and the stress fields improved dramatically. It was also found that having hierarchical nodes could lead to a reduction in the processing cost.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220111
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  • 198
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    Numerical control of the hourglass instability (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 219-228 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220116
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  • 199
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    Modifications to the interpretation of the stresses and strains determined using constant strain triangular elements (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 249-266 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 28 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220119
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  • 200
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    Improved strain interpolation for curved C° elements (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 22 (1986), S. 281-288 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The strain energy of straight beam members derived from the isoparametric shape functions is known to be invariant with respect to the number of integration points as long as they exceed a minimum number. However, this invariant property is generally lost for curved members. For example, the two-point integrated, membrane strain energy of curved beams by employing the quadratic shape functions is different from the three-point integrated one. This paper presents an invariant strain interpolation scheme for quadratic curved beam elements, which can lead to improved membrane representations in curved shell elements, thus resolving the perplexing membrane-bending coupling difficulties in thin shell analysis.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620220121
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