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  • 1970-1974  (526)
  • 1965-1969  (67)
  • 1920-1924
  • Engineering  (521)
  • Insulin
  • 1
    ISSN: 1432-0428
    Keywords: Insulin ; epinephrine ; lipolysis ; glucose metabolism ; fat cell ; adipose tissue ; plasma NEFA ; KK ; yellow KK ; C57BL ; diabetes ; genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adipose tissue of KK mice was less sensitive to insulin in its stimulatory action on glucose oxidation or its inhibitory action on lipolysis, and to epinephrine in its stimulatory action on lipolysis as compared to that of C57BL mice. A lack of appreciable increase in plasma NEFA in response to fasting of the KK mice might be caused by the impaired response of lipolysis to the hormones. — Adipose tissue of KK mice was also less sensitive to insulin-like action of concanavalin A, ouabaine or omission of K+ in the medium on glucose oxidation or lipolysis. Lipolysis in response to theophylline and/or DcAMP was less marked in the tissue of KK mice. The mean diameter of the adipocytes was larger in KK than in C57BL mice. In the experiments using adipocytes with the same diameter, however, the cells of KK mice were less sensitive to the hormones than those of C57BL. — With respect to tissue sensitivity to the hormones, the mean diameter of adipocytes and the response of plasma NEFA to fasting, the F1-hybrid mice of KK and C57BL showed values between those of the parental strains. Yellow hybrid (genetically obese F1-hybrid) mice showed higher sensitivity to insulin in the adipose tissue, more remarkable response of plasma NEFA to fasting as compared with KK mice, although hypertrophy of adipocytes was more pronounced in the yellow hybrid mice. — These findings suggest that insulin insensitivity is associated with epinephrine insensitivity in adipocytes of KK mice; both appear to be subjected to genetic factor(s)per se rather than hypertrophy of the adipocytes. Furthermore, insensitivity to both hormones in the KK mice appears to be caused by a common defect in cellular process other than the hormone receptor systems. These genetically determined abnormalities of adipocytes may result in fat-storage metabolism through hyperinsulinemia; this is very similar to the metabolic profile due to thrifty genotype in human diabetes as proposed by Neel.
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  • 2
    ISSN: 1432-2013
    Keywords: Active Sodium Transport ; Insulin ; Aldosterone ; Vasopressin ; Ouabain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Exposure of either the isolated urinary bladder or abdominal skin ofBufo marinus to the cardiac glycoside ouabain was regularly followed by reversible decreases of electrical potential difference and short-circuit current. Residual sodium-transporting activity, stable after 1–2h, was a function of the concentration of the glycoside. 2. Ouabain-inhibited preparations still reacted to vasopressin: the hormonal effect was decreased in amplitude only, and this in proportion to decrease in baseline activity; a similar observation was made when aldosterone was responsible for hormonal stimulation. 3. On the other hand, the insulin-induced increment in sodium transport was quite sensitive to ouabain inhibition so that this hormonal effect could be eliminated at moderate concentrations of the glycoside; the same held true when sodium transport was stimulated by addition of glucose to substrate-depleted preparations, especially when they were under the influence of aldosterone. 4. The persistence of residual hormonal effects in the presence of ouabain is interpreted as a type of response due to the stimuli (vasopressin, aldosterone in the absence of exogenous substrate) influencing a step distinct from, and probably proximal to, the ouabain-sensitive sodium “pump” mechanism proper. As for the increased ouabain effect noted on preparations stimulated by insulin or by glucose repletion, it suggests another type of response, possibly characterized by a facilitated interaction between ouabain and specific cell membrane ATP-ase set in operation as a consequence of these treatments.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 348 (1974), S. 333-342 
    ISSN: 1432-2013
    Keywords: Mouse Pancreas ; Amylase ; Glucose ; Insulin ; Glucagon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glucose inhibited amylase release from batch-incubated and perifused pieces of mouse pancreas. Insulin (100μg/ml) reduced the amylase secretion. These effects, however, seemed to be independent of each other, since diazoxide, a potent inhibitor of glucose-induced insulin release, did not abolish the effect of glucose on amylase secretion. Glucagon (10–100 μg/ml) had no effect on the release of amylase from incubated pancreas. Glucagon has previously been shown to inhibit exocrine secretionin vivo. The present results suggest that the inhibitory action of glucagon may be mediated via an increased level of serum glucose and the subsequent release of insulin.
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  • 4
    Electronic Resource
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    Springer
    European journal of pediatrics 117 (1974), S. 63-72 
    ISSN: 1432-1076
    Keywords: Growth hormone ; Newborn ; Glucose load ; Insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intravenous glucose tests (0.5 g/kg body weight) were performed in 13 newborn infants during their first 3 days of life. The variations in blood glucose, insulin and GH values were studied. In all patients there was a rise in plasma insulin. The correlation between initial insulin rise and glucose assimilation constant was 0.503 which is almost significant. The glucose load provoked a very variable response in plasma GH concentration, some infants showed a rise, others a fall. If the newborns were grouped according to this reaction it appeared that the GH response could be explained using Wilder's law of initial value. This hypothesis, however, did not stand up to a thorough statistical analysis including a discussion of a less well-known statistical error. In contrast to insulin secretion, GH apparently plays no major role in the short term regulation of the blood sugar in the newborn.
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  • 5
    Electronic Resource
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    Springer
    European journal of applied physiology 33 (1974), S. 215-226 
    ISSN: 1439-6327
    Keywords: Exercise ; Training ; FFA ; Ketones ; Insulin ; Growth Hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eight young men underwent a programme of training by running for 30 min at moderate speed three times a week for 4 weeks. Metabolic and hormonal changes in blood were studied during and after a run of 60 min at comparable speeds before and at the end of the training programme. Increases in lactate, pyruvate and plasma FFA during exercise were less after training. Increases in glucose were greater. There was a smaller increase in the post-exercise concentration of blood ketone-bodies after training. Plasma levels of insulin and human growth hormone (HGH) were lower after training. The fall in insulin and the rise in HGH during exercise were also smaller. There is a dissociation of the normal relationship between blood glucose and insulin during exercise. Insulin appears to be more important in the control of fat metabolism, in which its role may be altered by physical training. The changes observed in the longitudinal study of training imply that differences observed in cross-sectional studies of athletes and untrained subjects are not the result of an innate difference but do depend upon metabolic changes related to athletic training.
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  • 6
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 45-54 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper deals with a finite element formulation and solution of the boundary value problem of a concentrated force acting on a semi-infinite micropolar solid. A stiffness matrix is derived for a flat micropolar rectangular element in a plane state and use is made of this element to solve the case of the semi-infinite micropolar solid both in a state of plane stress and plane strain. An immediate application of the plane strain case is the important practical problem of a long line load acting on a soil mass which may be simulated as a micropolar body.
    Additional Material: 2 Ill.
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  • 7
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 111-117 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper presents an extension to the Matrix Transfer Method which gives quadratic convergence to a natural frequency from within a range on either side.The method is described and illustrated by application to: 1A torsional vibration problem, and2A lumped mass beam vibration problem.
    Additional Material: 2 Ill.
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  • 8
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 139-165 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A finite element formulation is presented for the equations governing the steady thermohydrodynamic behaviour of liquid lubricated bearings. This formulation permits application of the iterative solution scheme to bearings of arbitrary geometry.A generalized Reynolds equation resulting from the combination of the mass and momentum conservation equations is cast into variational form and used to derive general finite element equations. The method of weighted residuals with Galerkin's criterion is used to generate finite element matrix equations for the thermal energy equation. In addition to the finite element formulation, a discussion of appropriate finite difference techniques is also given for problems without complex geometry.As an example, the formulations are applied to obtain numerical solutions for a three-dimensional sector thrust bearing operating in the thermohydrodynamic regime. Pressure, velocity and temperature distributions are give, and the thermohydrodynamic solutions are compared with the results of classical isothermal theory.
    Additional Material: 11 Ill.
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  • 9
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 203-209 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 8 Ill.
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  • 10
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 215-225 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The development of a general quadratic multilayer plate element is presented for the analysis of arbitrarily layered curved plates. In the formulation, each layer of the multilayer plate can have different orthotropic properties and can deform locally. Examples of bending problems are presented which demonstrate the applicability of the formulation.
    Additional Material: 4 Ill.
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  • 11
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 249-269 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A structural optimization problem is considered in which the design requirements include restrictions on the strength, stability, frequency and flutter characteristics of the structure. One of the central concerns of this phase of the work has been to overcome the problems inherent in analysing the dynamic and aeroelastic behaviour of structures with many degrees of freedom. The multiweb delta wing structure under supersonic flight conditions is the model upon which this exploratory study is based. The finite element idealization, with three different kinds of elements, is used to model the wing structure. The constant stress triangular plate elements, the rectangular shear panels and the pin-jointed bar elements are used to represent, respectively, the cover skins, webs and stringers of the wing structure. The design problem is formulated as a minimum weight optimization problem and is solved by using non-linear programming techniques. Computationally efficient schemes are developed for the necessary derivatives of the behaviour constraints. Numerical examples are presented to illustrate the feasibility and the computational effectiveness of the method.
    Additional Material: 6 Ill.
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  • 12
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 311-321 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 2 Ill.
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  • 13
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 209-212 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 14
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 214-214 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 15
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 277-288 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: It is shown how the stress field due to any prescribed continuous distribution of dislocation dipoles can be determined. This technique then forms the basis of a general method of solution of elasto-plastic material problems. The presentation is limited to situations which conform to either plane stress or strain conditions. Some results are obtained for relatively simple geometrical and loading configurations and compared with classical plasticity solutions. Finally, the method is applied to the problem of a circular hole in a finite strip under tension.
    Additional Material: 10 Ill.
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  • 16
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 295-310 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Through the use of complex series representations and the properties of adjoint differential operators, a semi-analytical finite element procedure is developed which can analyse the steady state and transient temperature fields of thermally anisotropic axisymmetric bodies with complete circumferential properties. Due to its generality, the procedure can handle arbitrary laminate construction with possible meridional and radial variations in locally or globally thermally anisotropic materials. In this respect, the procedure developed herein supercedes the classical semi-analytical treatment which is limited to specially orthotropic materials. Furthermore, in contrast with the classical procedure, the present treatment reveals several important effects of material anisotropy which are entirely missed by the specially orthotropic assumption.
    Additional Material: 10 Ill.
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  • 17
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 395-401 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Physical reasoning makes it possible to use artificial parameters with numerical quadrature in order to obtain approximate solutions for the Fredholm integral equations associated with radiative heat transfer calculations. With the aid of such parameters, decisions can be made concerning the applicability and usefulness of the numerical quadrature technique.
    Additional Material: 6 Ill.
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  • 18
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 430-431 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 19
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 439-440 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 20
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974) 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 21
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 481-494 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A finite element weighted residual process has been used to solve transient linear and non-linear two-dimensional heat conduction problems. Rectangular prisms in a space-time domain were used as the finite elements. The weighting function was equal to the shape function defining the dependent variable approximation. The results are compared in tables with analytical, as well as other numerical data. The finite element method compared favourably with these results. It was found to be stable, convergent to the exact solution, easily programmed, and computationally fast. Finally, the method does not require constant parameters over the entire solution domain.
    Additional Material: 4 Ill.
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  • 22
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 503-511 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper deals with solving the two-dimensional variational problem for plate bending by the Ritz method using bicubic fundamental splines. It is a piecewise polynomial method, very adaptable to practical numerical computation, and can be an alternative for the well-known Finite Element Method1.
    Additional Material: 3 Ill.
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  • 23
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 821-845 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The visco-plastic model of material behaviour is of much practical interest in its own right and initial strain techniques for its solution have been developed and proved efficient. More important however is the fact that the visco-plastic model can be used to generate plasticity solutions in a simple manner when stationary conditions are reached and, at the other extreme, can reproduce standard creep phenomena. Used in this sense it allows the treatment of non-associated plasticity and strain softening situations which present difficulties in conventional plasticity approaches. A standard programme thus allows the treatment of a wide range of materially non-linear problems.The paper discusses various applications of the new general formulation and introduces certain numerical information on solution stability.
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  • 24
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 803-809 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The elastoplastic deformation of spherical shells of uniform thickness acted upon by external pressure is investigated in this paper. A deformation theory of plasticity is combined with the classical elasticity equations and a solution is obtained by the method of successive elastic solutions. A logarithmic effective stress-effective plastic strain diagram is used to determine the volume change for thick polypropylene spheres under the action of external pressure. These results are compared with previously published experimental volume changes in polypropylene spheres. This comparison shows that the predicted volume changes are similar to the experimental results.
    Additional Material: 1 Ill.
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  • 25
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 913-914 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 26
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 917-918 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 27
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 212-212 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 28
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 271-276 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The fitting of a function y =\documentclass{article}\pagestyle{empty}\begin{document}$ \sum\nolimits_{i = 1}^n {A_i {\rm{e}}^{\lambda ix}} $\end{document} to experimental data is considered. Integral equations are developed which have the functions \documentclass{article}\pagestyle{empty}\begin{document}$ \sum\nolimits_{i = 1}^n {A_i {\rm{e}}^{\lambda ix}} $\end{document} as their solutions for n = 1, 2, 3, These integral equations are used to find the frequencies λi. Examples are worked out to illustrate the method. The method is shown to be capable of extension to other functions.
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  • 29
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 289-294 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: To obtain meshes of reasonable form there have to be made some restrictions in the application of automatic mesh generation schemes using ‘isoparametric’ co-ordinates. In this present paper it will be shown that such restrictions exist for plane meshes. The results figured here are also valid for three-dimensional meshes.
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  • 30
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 341-358 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A least square based finite element algorithm is developed for some elasto-static problems. In the formulation both stresses and displacements appear as simultaneous variables. In two dimensional (plane) analysis, parabolie isoparametric elements are used. Considerable improvement of performance is obtained with a numerical integration based on 2 × 2 Gauss point distribution over more accurate integration schemes. Reasons for this are presented.The formulation is extended in the section ‘General least square formulation’ to beams and plates with a similar success of ‘reduced’ integration.
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  • 31
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 323-339 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A finite strip method is presented for determining the initial buckling stresses of any structure consisting of a series of thin flat isotropic plates rigidly connected together at their longitudinal edges. Each plate may be subjected to a combination of longitudinal and transverse compression, longitudinal in-plane bending, and shear, and it is assumed that the buckling mode, of whatever type, is sinusoidal in the longitudinal direction. Due to the presence of shear, the perturbation forces and displacements which occur at the edges of component plates during buckling are out of phase, and this is accounted for by defining their magnitudes in terms of complex quantities. Stiffness matrices relating the amplitudes of these forces and displacements are derived using an approximate method based upon assumed displacement functions across the width of the plate. It is shown how the method can be used to calculate natural frequencies of prismatic structures, and finally an indication of the accuracy of the method is given together with some illustrative results.
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  • 32
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 403-414 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: By representing the time-dependent material properties by mechanical models, i.e. the generalized Maxwell and/or Voigt (or Kelvin) models, it is possible to formulate a consistent procedure to analyse the effect of material damping on dynamic response. As a continuation of the previous work which concerned the creep and relaxation of viscoelastic materials, the present paper applies this representation to the harmonic response analysis. The harmonic solution can be obtained by decomposing the relevant forces and displacements into real and imaginary parts and it is shown that the modal analysis by an appropriate eigensolution procedure is useful for obtaining the dependence of vibration amplitude on frequencies of sinusoidal external excitations.
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  • 33
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 513-519 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Edge displacement of assumed-stress hybrid plate elements are commonly chosen as either linear, quadratic or cubic functions of the edge co-ordinate. The present paper examines the effect of this choice on the acceptability, accuracy, and possible zero energy modes of elements based on a linear stress field. It is concluded that triangular elements may be preferable to quadrilaterals, and that linear edge displacements are not desirable.
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  • 34
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 537-545 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The development of a generalized quadrilateral finite element that includes a singular point at a corner node is presented. Inter-element conformability is maintained so that monotone convergence is preserved. The global-local concept of finite elements is used to formulate the complete set of equations. Examples of crack tip singularities are given.
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  • 35
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 547-567 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The triangular element is one of the most useful finite difference elements for the potential problems because of its versatility in fitting irregular boundary, in connecting one element type to another, and in changing grid fineness. Such triangular elements find many applications in conduction problems in cartesian co-ordinates. This paper presents a new triangular element for the finite' difference solution of axisymmetric conduction problems in cylindrical co-ordinates. The validity of the proposed triangular element is analyzed, and its workability is demonstrated using three selected examples. Also, an industrial application highlights the advantageous characteristics of the triangular element, and gives a comparison with known results obtained by finite element method.
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  • 36
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 569-588 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Basic equations are derived for a comprehensive computer analysis for an equivalent lumped parameter system which simulates a pre-twisted, rotating or non-rotating. Timoshenko beam in coupled bending-bending-torsion vibrations. These equations enable one to develop straightforwardly digital computer programs for studying vibration problems related to compressor or turbine blades in turbomachinery as well as in other structural dynamics applications. The validity of the lumped parameter approach is established through a free vibration study. Good agreement between the present computer results and those obtained theoretically or experimentally by other investigators is demonstrated. In particular, it is found that the natural frequencies obtained in the free vibration study for all beams examined converge from below the exact values at a convergence rate of N-4, where N is the total number of the lumped parameters used in the computer simulation. The rapid rate of convergence shows that the mathematical model used in deriving the basic equations can adequately represent the type of beams under consideration. The known convergence rate also provides an estimate on the accuracy of the computer results, and a means to improve these results by extrapolation.
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  • 37
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 659-661 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 38
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 662-670 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A unified procedure is presented for the automatic generation of the coefficient matrix of finite difference equations. The method is applicable to the solution of both initial and boundary value problems, to any order of difference equation, and may be used with any arbitrary initial or boundary conditions.
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  • 39
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 671-675 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A method of determining the torsional stiffness of a wide range of structural sections, both homogeneous and composite, is presented. Prandtl's stress function along the boundaries of component sections is approximated by finite Fourier series with coefficients chosen to minimize a functional. An example indicates that the stiffness may be determined to acceptable accuracy by the solution of very few equations.
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  • 40
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 697-711 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: It is shown how the elasticity equations can be formulated in terms of a general procedure of abstract analysis, called the projective method, for constructing an approximate solution. This allows the many studies of convergence and uniqueness of solutions which have been made in modern mathematics to be applied to the elasticity problem. The abstract formulation also suggests an organizational scheme for generating a computer code. A computer code for hollow or solid cylinders of arbitrary cross section was developed and several numerical examples are presented. The procedure is computationally advantageous for the class of problems under consideration because of the relatively small number of equations that must be solved as compared to the finite element method. The results presented demonstrate the accuracy of the method.
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  • 41
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    International Journal for Numerical Methods in Engineering 8 (1974) 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 42
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 743-770 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The discrete (Legendre) orthogonal polynomials, (DLOP's) are useful for approximation purposes. This set of mth degree polynomials {Pm(K, N)} are orthogonal with unity weight over a uniform discrete interval and are completely determined by the normalization Pm(O, N) = 1. The authors are employing these polynomials as assumed modes in engineering applications of weighted residual methods. Since extensive material on these discrete orthogonal polynomials, and their properties, is not readily available, this paper is designed to unify and summarize the presently available information on the DLOP's and related polynomials. In so doing, many new properties have been derived. These properties, along with sketches of their derivation, are included. Also presented are a representation of the DLOP's as a product of vectors and matrices, and an efficient computational scheme for generating these polynomials.
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  • 43
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 783-801 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The patch test is shown to be contained in the variational formulations of the finite element methods at the assembling level, all of which require the vanishing of the virtual work of interface connection loads. By a systematic introduction of stress generating functions, attention is drawn to the fact that any given finite element model can be assembled in two different ways: either by identification of a set of boundary displacements (leading to the direct stiffness method), or by identification of a set of local stress function values (leading to the dual direct flexibility method). Looking at any conjugate couple (generalized displacement-generalized surface traction) at an interface, one is strongly transmitted, the other weakly. Discretization of the zero virtual work condition at an interface of plate bending models, by means of Legendre polynomial expansions, allows a systematic construction of so-called ‘non-conforming’ elements that pass the patch test. They are in fact identified with weakly conforming, but strongly diffusive, hybrids, and the lowest degree element (quadratic) is in fact the Morley constant-moment element. Examples are given for higher degree displacement fields.The case of plate stretching elements can be handled by duality, the difficulties being here associated with the requirements for diffusivity. Non-diffusive elements that pass the zero interface virtual work test can be constructed systematically and are identifiable with weakly diffusive, but strongly conforming, hybrids of the type first proposed by T. H. H. Pian.
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  • 44
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    International Journal for Numerical Methods in Engineering 8 (1974) 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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  • 45
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 27-43 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: Body oriented co-ordinates are defined for three-dimensional regions bounded by six surfaces. From this definition of body oriented co-ordinates, two transformations are derived: 1Body oriented surface co-ordinates to the Cartesian co-ordinates, and2Body oriented co-ordinates for a three-dimensional region to Cartesian co-ordinates.With these transformations a mesh generator is developed based on the principle that the mesh required to describe a region will be calculated according to the placement of the discrete points that describe the boundary edges. This is accomplished with two versions of the mesh generator: the surface generator and the volume generator. The surface generator maps the four boundaries of the surface onto the four boundaries of a unit square. Next, the interior points for the surface mesh are established in the mapped space. Then, using the first transformation, the co-ordinates for the surface nodal points are calculated. Similarly, the volume generator maps the six surfaces of the body onto the surfaces of a unit cube, establishes the interior nodal points in the mapped space, and using the second transformation, calculates the co-ordinates for the interior nodal points.
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  • 46
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 359-367 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper describes a method of solving electromagnetic induction problems by means of the finite element technique. A variational equation associated with the differential equation for the vector potential is formulated and solved via the concept of finite elements. Sinusoidal driving currents and linear, isotropic, but inhomogeneous media are assumed. A typical example is included in order to illustrate the suggested solution technique.
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  • 47
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 369-394 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The mesh generation program described here generates the nodes and the elements for excavated highway slopes, applies boundary conditions, searches for the nodes and the elements in each layer excavated and plots the mesh with the numbering of nodes, elements and material types.
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  • 48
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 415-424 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A finite element analysis applicable to elasto-plastic shells of arbitrary shape is presented. Small-deflection behaviour of thin shells subjected to monotonically increasing static loads is considered. The material is assumed to be originally isotropic, following the von Mises yield criterion and the Prandtl-Reuss flow rule. A flat triangular element with twelve degrees of freedom is used in the analysis. Within each element both membrane forces and bending moments are assumed to be constant. Some numerical results are included to illustrate the merits of the element.
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  • 49
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 425-429 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A procedure to deal with various boundary conditions in the Rayleigh-Ritz method is discussed herein, namely, the method of artificial parameters. The method is then applied to solve a simple string problem; results obtained compare very nicely with exact solutions.
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  • 50
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 431-432 
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  • 51
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 433-437 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: One of the first finite elements presented was that by Turner et al.1 Pian2 presented a hybrid plane stress element and Wilson et al.3 presented a non-conforming displacement element. It is shown that the three resulting stiffness matrices are identical.
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  • 52
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 461-480 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The concepts and potential advantages of local and global least squares smoothing of discontinuous finite element functions are introduced.The relationship between local smoothing and the ‘reduced’ integration' technique is established.Examples are presented to illustrate the application of the two smoothing techniques to the finite element stresses from several structural analysis problems.The paper concludes with some practical recommendations for discontinuous finite element function smoothing.
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  • 53
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 495-501 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: In a two-dimensional space of points on an equilateral triangle grid, a single difference equation holding at each node is found from the finite element formulation of the wave equation for all published polynomial orders of the functional expansion. Assuming homogeneous boundary conditions on any equilateral triangle whose edges and vertices pass through the grid points, the eigensolutions of the difference equation are found exactly and thus provide an excellent test problem for the programmer or engineer. The advantage of the present method over other formulations is that the number of linear operations required to produce the difference equation is minimal.
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  • 54
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 429-430 
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  • 55
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 432-432 
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  • 56
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 438-438 
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  • 57
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 443-460 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A number of problems are analysed by the displacement method to assess the stress accuracy at very low compressibilities. ‘Parabolic’ isoparametric elements are used. It is found that the mean stress becomes grossly in error at the centre and edges of each element as the compressibility is reduced whereas the deviatoric stress components do not. All stress components retain good accuracy at the ‘reduced’ integration sampling points (2 × 2 Gauss). ‘Exact’ integration yields a similar stress distribution to ‘reduced’ but the mean stress is grossly in error at the integration points (3 × 3 Gauss). Exceptions, however, occur.These findings are interpreted, and a rule for predetermining whether or not accurate stresses can be obtained at the integrating points is suggested. Thus it is shown that the displacement method is suitable for analysing materials which for practical purposes are incompressible.A procedure is then presented for analysing porous media-both linear and non-linear-by separating the stiffness into ‘effective’ and ‘pore fluid’ components. This allows excess pore pressure to be calculated explicitly. Applications to saturated soils are given which make use of the findings of the first part of the paper.
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 529-536 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The steady state flow problem known in magnetohydrodynamics as Hartmann's flow is converted into variational formulation and is given an approximate solution by means of the spline blended interpolation technique. The equations of motion consist of two coupled potential flow problems with homogeneous boundary conditions. The spline blended interpolation method is reduced here, because of the shape of the domain, to a cartesian product of cardinal splines with trigonometric or ordinary polynomials. ‘Exact’ boundary conditions are presented by the blending technique. The numerical results indicate that high accuracy is possible with relatively few unknowns.
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  • 59
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 613-624 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The paper presents a generally applicable approach to transient heat conduction problems with non-linear physical properties and boundary conditions. An unconditionally stable central algorithm is used which does not require iteration.Several examples involving phase change (where latent heat effects are incorporated as heat capacity variations) and non-linear radiation boundary conditions are given which show very good accuracy.Simple triangular elements are used throughout but the formulation is generally valid and not restricted to any single type of element.
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 625-631 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A program is demonstrated which apart from linear finite elements in time also includes elements with shape functions of the second and third degree. The algorithm for discretization in the time dimension is described and, using the example of a parabolic time element, the coefficients required to form the global system are given. By various test examples the efficiency of the process is examined by comparison with the customary difference method. Generally, with finite elements in time, the solution has better stability. Comparing the time required for calculation with the accuracy of the solution it would appear that in examining problems where boundary conditions are constant in time, higher order time elements are no improvement over the linear time element. However, for the purpose of reproducing periodic processes, higher order time elements offer an advantage in that one is not limited to linear variations of the boundary conditions within the element. Thus, for example, the temperature curve for parabolic variation of the surface temperature can be reproduced with close approximation by two time elements per period and a shape function of the third degree.
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 676-676 
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    Keywords: Engineering ; Engineering General
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  • 62
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 771-781 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The steady two-dimensional, viscous, electrically conducting flow around a circular cylinder is investigated. The flow and magnetic field are uniform and parallel at large distances from the cylinder. The equations and boundary conditions are derived for arbitrary values of R, Rmand β, where R is the Reynolds number, Rm the magnetic Reynolds number and β, the ratio of the square of the Alfvén speed to the square of the main stream speed. Because of the large number of parameters involved, the numerical solution is restricted to R = 40, Rm = 1 and infinity and 0 ≤ β ≤ 4. Also the cylinder is taken to be a perfect conductor, this avoids having to compute the magnetic field within the cylinder.The numerical computations for the non-magnetic case, i.e. β = 0, are presented and are found to be in good agreement with existing results. The effect of increasing the strength of the magnetic field (i.e. increasing β) on the drag coefficient, the size and position of the standing vortex and the increasing effect of the upstream propagation of disturbances are examined.
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 811-820 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: We describe a finite element method for the one-dimensional Stefan problem. The elements are quadrilaterals of the space-time plane which are determined at each time-step in relation with the position of the free boundary. The method appears as a generalization of the classical Crank-Nicolson scheme, since it is identical to this scheme in the case of rectangular elements; it has the advantage of providing a simple and accurate determination of the free boundary. Numerical experiments show that the order of accuracy is equal to 2.
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 865-876 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: Based on the least squares error criterion, a class of finite element is formulated for the numerical analysis of steady state viscous boundary layer flow problems. The method is essentially a discrete element-wise minimization of square and weighted residuals which arise from the attempts in approximately satisfying boundary layer equations. An iterative linearization scheme is developed to circumvent the mathematical difficulties posed by the non-linear boundary layer equations. It results in a process of successive least squares minimizations of residual errors arising from satisfying a set of linear differential equations. A mathematical justification for the method is presented. A major feature of the method lies in the linearization approach which renders non-linear differential equations amenable to linear least squares finite element analysis. Another important feature rests on the proposed finite element formulation which preserves the symmetric nature of finite element matrix equations through the use of the least squares error criterion. Numerical examples of viscous flow along a flat plate are presented to demonstrate the applicability of the method as well as to illuminate discussions on the theoretical aspects of the method.
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 917-917 
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    Keywords: Engineering ; Engineering General
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  • 66
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 847-864 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A finite beam-column element computer program for the structural failure analysis of proportionally loaded skeletal plane frames is described. The program, which is based on an iterative stiffness approach, provides for non-linear elastic or plastic-non-linear elastic behaviour. Particular attention is given to the incorporation into the analysis of geometrical imperfections, return of elasticity at plastic hinges and negative frame stiffness. The effect of lack-of-fit displacements on the load-deflection path and failure load of frames that carry relatively large axial loads is described in general terms. The theory is developed further through the application of the computer program to two examples which show the necessity for the allowing for the effect of imperfections when designing axially loaded redundant frames.
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  • 67
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    Notes: This article presents an efficient numerical algorithm a complete listing of the associated computer program, developed for the eigenproblem solution of discrete damped structures, including spinning ones. The numerically stable procedure is based on a combined Sturm sequence and inverse iteration technique, which fully exploits the banded form of the relevant matrices and proves to be most substantially economical when compared to similar existing softwares. Numerical results are presented for representative structures, solved by the present computer program written in FORTRAN V for the JPL UNIVAC 1108 computer.
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 17-25 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: Three variational statements for the slow time-independent flow of a Navier-Poisson fluid are derived. All of these statements are suitable as the bases of finite elements. The first statement is applied successfully to several flow situations.
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 91-102 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: This paper deals with the numerical solution of wave propagation problems in general although the primary area of interest is elastodynamics. The work is applicable to a variety of wave propagation phenomena of classical physics. Explicit schemes of Strang type are used, which allow many simplifications over existing methods. The Strang schemes allow in a very real but perhaps unexpected way the splitting of the elasticity operator.
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  • 70
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 71-90 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: By use of the least squares error criterion, an alternate finite element formulation is presented. The method is based on the discrete or element-wise minimization of square and weighted differential equation residuals which are expressed in terms of element nodal quantities. In order to overcome the stringent inter-element continuity requirement, a major stumbling block, on the element trial functions two practical schemes are proposed. One is the reduction of the original governing differential equation to a system of equivalent first order differential equations; the other is a method of smoothing discontinous trial functions. The latter essentially relaxes the continuity requirement and yields efficient non-conforming finite elements. This paper also demonstrates the use of constant weights which significantly improves the rates of convergence. Several numerical examples illustrate the proposed method. From these examples, it may be concluded that the use of constant weights and the relaxation of the inter-element continuity requirement are two indispensable features of the weighted discrete least square method.
    Additional Material: 17 Ill.
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  • 71
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 119-138 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A direct method is described for the evaluation of the critical loads on deep circular arches having various forms of end support. The method is applicable to arches of non-uniform flexural rigidity and may cater for arbitrary forms of applied load distribution. The results calculated for two examples are given, and compared with those obtained analytically and experimentally by other investigators. A complete listing of a computer program for one of the examples is provided in the Appendices.
    Additional Material: 10 Ill.
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  • 72
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 195-198 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A finite element method for the analysis of axisymmetric bodies in torsion is presented. The effects of an angular acceleration about the axis of symmetry is included. The accuracy of the method is tested against experimental results available for a stepped shaft and finally the problem of an accelerating shaft-turbine disc system is considered.
    Additional Material: 3 Ill.
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  • 73
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 1-16 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: When large, progressive, deformation occurs under plastic or visco-plastic conditions, elastic deformations are negligible and the material flows in a viscous manner. The flow is non-Newtonian and the viscosity is a function of the current strain rates. An effective numerical treatment of such non-Newtonian flow by the finite element method is indicated here and is illustrated by examples of an extrusion process for which approximate slip line solutions are known.The methodology is extended to the solution of transient, quasi-static situations and coupling with thermodynamic equations is discussed.A stream function formulation of the problem is used.
    Additional Material: 11 Ill.
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  • 74
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 55-69 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The finite element method is applied to dynamic linear viscoelastic analysis. The arising system of differential equations is integrated by means of the Laplace transformation. The direct numerical evaluation of the inversion integral seems to be appropriate in case of vibrational problems. The method is applied to examples of transient vibrations of elastic bodies. Initial conditions and arbitrary damping matrices can be considered.
    Additional Material: 6 Ill.
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  • 75
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 103-110 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper discusses three numerical integration schemes connected with a finite element solution to the transient heat-conduction equation. The main emphasis is on the achievable accuracy. A simple recurrence relation derived from the Galerkin process is suggested for the treatment of fast-varying boundary conditions as being significantly better than the usual Crank-Nicholson scheme in matters of short-time accuracy.
    Additional Material: 4 Ill.
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  • 76
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 167-194 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Use of mixed force and displacement variables may be the key to a reliable solution of many physical problems. For the analysis of elastic structures with large rigid motion the displacement method may fail due to illconditioning, but use of mixed variables (diacoptics) may work due to the possibility of using relative displacements within substructures. Analysis with mixed variables complicates the topology (the number of nodes and the number of variables at the nodes may vary in the same problem) so a careful study of the system analysis is required. Some general computer routines are given for handling topology, merging and solution of the sparse system equation. The solution routine handles constraints in a rational way and can also be used for decomposition of the system equation or for releasing inner nodes in superelements.
    Additional Material: 13 Ill.
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  • 77
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 198-203 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The application of the static condensation method is discussed in general. The technique is presented as an extension of the Gauss elimination algorithm. An efficient FORTRAN subroutine is given which simultaneously reduces both the stiffness matrix and the stress-displacement transformation matrix.
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  • 78
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 212-212 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 79
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    International Journal for Numerical Methods in Engineering 8 (1974) 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 80
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 227-248 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An integrated sequential computer programme for the solution of large linear algebraic systems encountered in the discrete analysis of complex structures using finite element idealization is described. The programme uses an algorithm based on Gauss elimination for solution and is independent of the possible symmetric nature of the system matrix thus enhancing the applicability of the programme for systems with unsymmetric coefficient matrices. The present programme can handle large band widths and the core memory is used efficiently for all feasible problem sizes. A FORTRAN print-out of the programme with relevant explanatory comments and a full notation list are appended.
    Additional Material: 2 Ill.
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  • 81
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 521-528 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Two methods are presented for the automatic selection of a cycle basis leading to a sparse flexibility matrix for the analysis of rigid-jointed skeletal structures.The first method having a local approach forms a maximal set of admissible minimal cycles, while the second having a global approach constructs admissible minimal cycles on the ordered chords of a shortest route tree. A cycle ordering algorithm is also given to reduce the band width of the corresponding flexibility matrix.
    Additional Material: 3 Ill.
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  • 82
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 589-611 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper presents a method of solving systems of simultaneous non-linear partial differential equations using the method of lines and the method of quasilinearization-superposition in combination. The advantages of the method over those methods more generally used are discussed and an example of the application of the method to the two-dimensional momentum and energy equations considering temperature-dependent and/or shear-rate dependent viscosity is given.
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  • 83
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 649-657 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Additional Material: 4 Ill.
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  • 84
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 633-647 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The method of ‘least squares’, which falls under the category of weighted residual processes, is applied as a time-stepping algorithm to one-dimensional transient problems including the heat conduction equation, diffusion-convection equation, and a non-linear unsaturated flow equation. Comparison is made with other time-stepping algorithms, and the least squares method is seen to offer definite advantages.
    Additional Material: 8 Tab.
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  • 85
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 676-676 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 86
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 679-696 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The object of this paper is to describe a new algorithm for the semi-automatic triangulation of arbitrary, multiply connected planar domains. The strategy is based upon a modification of a finite element mesh genration algorithm recently developed. 1 The scheme is designed for maximum flexibility and is capable of generating meshes of triangular elements for the decomposition of virtually any multiply connected planar domain. Moreover, the desired density of elements in various regions of the problem domain is specified by the user, thus allowing him to obtain a mesh decomposition appropriate to the physical loading and/or boundary conditions of the particular problem at hand. Several examples are presented to illustrate the applicability of the algorithm. An extension of the algorithm to the triangulation of shell structures is indicated.
    Additional Material: 19 Ill.
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  • 87
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 731-741 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A polynomial shape function of triangular elements for finite element analysis of general deformation of sheet metals with or without orthotropic anisotropy is proposed. And general formulation for large deformation and large strain analysis with non-linearity of material property, say plasticity, is given. Some numerical examples are examined with respect to hydraulic bulging.
    Additional Material: 6 Ill.
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  • 88
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 713-729 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A characteristic feature of the variational functionals for several boundary value problems in polar co-ordinates is the fact that one independent variable occurs explicitly in the denominator. Therefore, the coefficients of the finite element equations for sectors of circular ring shaped elements are not constants but functions of the distance of the elements from the origin of co-ordinates.1 We name them coefficient functions. In order to show the particular aspects of the calculations in terms of polar co-ordinates we deal here with the solution of the torsion problem by bilinear and bicubic Hermitian interpolation.The finite element equations are arranged according to Schaefer2 in the form of block which can easily be transformed into ‘stars’3 or molecules4,5 similar to those used in finite difference methods. The origin of co-ordinates requires a special consideration, firstly because of the coincidence of several nodes at that point and secondly because of the divergent behaviour of some coefficient functions. It turns out to be advantageous for the numerical calculations to expand the coefficient functions in power series. Besides, the expansions are required to deduce the equations for rectangular elements by limiting processes. The twisting moments and shearing stresses calculated for several cross sections illustrate the numerical suitability of the method. The finite element values are compared partly with exact solutions and partly with experimental results obtained by a moiré method using Prandtl's soap film analogy.6 Finally it is shown how the accuracy of the finite element values can be improved by the Richardson extrapolation7.
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  • 89
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    International Journal for Numerical Methods in Engineering 8 (1974), S. 914-916 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The paper shows a procedure for estimating the shape parameter of a Gamma distribution from a sample. This procedure uses a rapidly converging iteration to solve the maximum-likelihood equation and suggests a simple formula for determing the starting value.
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  • 90
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    Calcified tissue international 12 (1973), S. 8-15 
    ISSN: 1432-0827
    Keywords: Insulin ; Bone ; Calcium ; Resorption ; Orthophosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé L'administration d'insuline cristallisée à des rats thyroparathyroidectomisés provoque une augmentation de la calcémie et de la phosphorémie. Le calcium plasmatique s'élève de façon linéaire entre 31 et 250 m Unités d'insuline/100 g de poids corporel. La courbe obtenue n'est guère différente de celle obtenue par extrait parathyroidien. L'administration simultanée d'insuline et d'extrait parathyroidien à des rats thyro-parathyroidectomisés agit sur la calcémie et la phosphorémie par un effet additif. Lorsque des os frontaux d'embryons de poulet sont cultivésin vitro en présence d'insuline cristallisée, le taux de résorption augmente. L'insuline augmente le taux de consommation en glucose des explants et induit une accumulation de citrate dans le milieu de culture. L'insuline stimule donc la résorption osseuse.
    Abstract: Zusammenfassung Der Plasmagehalt an Calcium und Phosphor bei thyroparathyreoidektomierten Ratten wurde durch die Verabreichung von kristallinem Insulin erhöht. Das Plasmacalcium verhielt sich zwischen 31 und 250 m Einheiten Insulin pro 100 g Körpergewicht linear. Die Steigung der erhaltenen Kurve ist nicht signifikant verschieden von derjenigen, die nach Parathyreoidea-Extrakt erhalten wird. Die gleichzeitige Verabreichung von Insulin und Parathyreoidea-Extrakt von thyroparathyreoidektomierten Ratten hatte eine kumulative Wirkung auf den Gehalt von Calcium und Phosphor im Plasma. Wenn Stirnbeine von Kükenembryos mit kristallinem Insulinin vitro kultiviert wurden, erhöhte sich die Resorptionsrate. Das Insulin steigerte den Glucoseverbrauch der Explantate und verursachte eine Anreicherung von Citrat im Kulturmedium. Die Ergebnisse deuten auf eine Stimulation der Knochenresorption durch Insulin.
    Notes: Abstract the administration of crystalline insulin to thyroparathyroidectomized rats raised their calcium and phosphorus plasma levels. The plasma calcium gave a linear response between 31 and 250 mU of insulin/100 g body weight. The slope obtained is not significantly different from that obtained with parathyroid extract. The simultaneous administration of insulin and parathyroid extract to thyroparathyroidectomized rats affected the calcium and phosphorus plasma levels in an additive fashion. When chick embryo frontal bones were cultivatedin vitro with crystalline insulin the rate of resorption increased. Insulin increased the rate of glucose consumption by the explants and induced the accumulation of citrate in the culture medium. It is concluded that insulin stimulates bone resorption.
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  • 91
    ISSN: 1433-8580
    Keywords: Insulin ; Intestinal hormones ; Atropine ; Vagus ; Insulin ; Intestinale Hormone ; Atropin ; Vagus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung und Schluβfolgerung Bei 35 stoffwechselgesunden freiwilligen Probanden wurde vor sowie nach Atropingabe die Wirkung der intestinalen Hormone Sekretin und Cholecystokinin-Pankreozymin (CCK-PZ) auf die endokrine und exokrine Pankreasfunktion untersucht. Außerdem wurde die Wirkung von intravenös und oral bzw. intraduodenal verabreichter Glucose und Aminosäuren auf die Insulinsekretion, den Blutzucker und die freien Fettsäuren ebenfalls vor und nach Atropinmedikation geprüft. Intravenös verabreichtes Sekretin konnte weder in seiner exokrinen noch endokrinen Pankreasfunktion durch Atropin beeinflußt werden. Intravenös injiziertes CCK-PZ konnte mittels Atropin sowohl in seiner ekbolischen wie auch endokrinen Pankreasfunktion gehemmt werden. Die Wirkung von CCK-PZ ist somit an ein cholinerges System gebunden, so daß es erlaubt erscheint, bezüglich der Pankreozyminwirkung von einem synergistisch bzw. additiv wirksam werdenden „neurohormonalen“ Mechanismus zu sprechen. Die durch parenteral verabreichte Glucose oder Aminosäuren induzierte Insulinsekretion wurde durch Atropin nicht beeinflußt; hingegen hemmte Atropin dieβ-cytotrope Wirkung von oral bzw. intraduodenal verabreichter Glucose oder Aminosäuren. Dies läßt auf eine Abhängigkeit von einem cholinergen oder parasympathischen System in der Freisetzung dieser intestinalen Hormone schließen.
    Notes: Summary and Conclusions In 35 metabolically normal subjects the effect of i.v. secretin and cholecystokinin-pancreozymin (CCK/PZ) on the endocrine and exocrine pancreatic function was investigated, before and after atropine. In addition, the effect of oral, intravenous and intraduodenal administration of glucose and amino acids on blood sugar and free fatty acids before and after the injection of atropine was studied. The secretin stimulated endocrine and exocrine pancreas was not affected by atropine. However, atropine inhibited the ecbolic and endocrine pancreatic function after stimulation with CCK/PZ. Therefore, the effect of i.v. CCK/PZ seems to be mediated by the cholinergic system, or even a “neuro-hormonal” system which acts synergically or additively. No influence of atropine on the insulin secretion induced by i.v. glucose or amino acids was observed. On the other hand, atropine inhibited the beta-cytotropic effect of glucose and amino acids after oral or intraduodenal administration. These findings indicate that the release of these intestinal hormones is dependent on the cholinergic or parasympathetic system.
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  • 92
    ISSN: 1433-8580
    Keywords: Small intestine ; Absorption ; Insulin ; Man ; Dünndarm ; Resorption ; Insulin ; Mensch
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß von Insulin auf die Resorption von Glucose, Wasser, Natrium und Kalium wurde mittels der segmentalen Dünndarmperfusion mit einer dreilumigen Sonde untersucht. Nach Messung der Resorption über zwei 30 min-Perioden wurden den Probanden 1,0 g Tolbutamid (Rastinon®) bzw. 20 IE Insulin (Actrapid®) intravenös injiziert und danach die Resorption über vier 15 min-Perioden bestimmt. Ergebnisse 1. Stoffwechselgesunde zeigten sowohl nach Injektion von Tolbutamid und dadurch induzierter Erhöhung des Seruminsulinspiegels als auch nach Insulininjektion eine signifikante Minderung der Resorption. 2. Diese Resorptionsminderung war auch nachweisbar, wenn Glucose zur Verhinderung des Blutzuckerabfalls unmittelbar nach der Insulininjektion infundiert wurde. 3. Insulinbedürftige Diabetiker lassen nach der Injektion von Tolbutamid — offenbar infolge fehlender Insulinsekretion — keine Resorptionsänderungen erkennen, zeigen aber eine Transportminderung nach Insulininjektion. Diese Befunde belegen, daß die Glucose-, Wasser-, Natrium- und Kaliumresorption im menschlichen Dünndarm durch Insulin reduziert wird.
    Notes: Summary The influence of insulin on the intestinal absorption of glucose, water, sodium and potassium was investigated in man using a triple lumen tube technique. After an absorption period of 60 min 1 g of tolbutamide was injected in order to stimulate endogenous insulin secretion. Alternatively 20 units of regular insulin were applied intravenously. Thereafter absorption was studied over 4 periods of 15 min duration. Results: 1. In healthy subjects the absorption of glucose water, sodium and potassium was decreased after the injection of tolbutamide as well as after the injection of insulin. 2. The decrease in absorption was also demonstrable when the insulin induced reduction of blood sugar levels was abolished by intravenous glucose infusion. 3. In insulin dependent diabetics there was no decrease in absorption after injection of tolbutamide. This was due to the unability to secrete insulin. On the other hand a decrease in absorption occurred if insulin was applied in insulin dependent diabetics. These results demonstrate that the absorption of glucose, water, sodium and potassium from the human intestine is reduced by insulin.
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  • 93
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    Diabetologia 9 (1973), S. 447-452 
    ISSN: 1432-0428
    Keywords: Insulin ; obese mice ; pancreas ; glucose ; amino acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pancreatic insulin content and insulin secretion, from the pancreas of obese mice fed ad lib (ob/ob), obese mice maintained on a restricted diet (ob/ob RD) and lean mice has been studied using incubated pieces of pancreas in vitro and in a perifusion system. The ob/ob mice pancreas contained approximately twice as much insulin as the lean mice pancreas, whereas the ob/ob RD mice had a normal insulin content. Increasing the glucose concentration had a marked and prolonged stimulating effect on insulin secretion in the pancreas of the ob/ob and ob/ob RD mouse, but not in the lean mouse. Leucine stimulated insulin secretion in all three groups of animals both in the absence and presence of glucose in a biphasic manner; in the presence of glucose the insulin secreted from the pancreas of the ob/ob and ob/ob RD mice was abnormally high. Arginine stimulated insulin secretion from the lean mouse pancreas in the absence of glucose, whereas in the obese mouse pancreas stimulation was observed only in the presence of glucose, and the effect increased with increasing glucose concentration. The large amounts of insulin which can be secreted by the pancreas of the ob/ob and ob/ob RD mice under stimulation suggest that an abnormal response of the pancreas to biological stimuli of insulin secretion could be a primary defect in these animals.
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  • 94
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    Diabetologia 9 (1973), S. 174-177 
    ISSN: 1432-0428
    Keywords: Insulin ; clearance ; perfusion ; radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hepatic insulin clearance was studied in normal male and female Wistar rats using the isolated liver perfusion technique and the dextran coated charcoal radioimmunoassay for insulin. The following results were obtained: — 1. In male rats there was a progressive increase in clearance with increasing body weight, liver weight and age. — 2. In adult female rats clearance was significantly greater than in comparable males, but no relationship between liver weight and clearance was observed. — 3. With each increase in insulin concentration there was an apparent decrease in clearance.
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  • 95
    ISSN: 1432-2013
    Keywords: RQ ; Insulin ; Glucose ; Lactate ; Pyruvate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary RQ, plasma insulin, blood glucose, lactate and pyruvate were measured in six fit, normal subjects during a series of exercise and rest experiments with and without sucrose ingestion. Subjects exercised on a bicycle ergometer for 50 min of every hour for 6 h at about 47% of the group's average maximal aerobic capacity. In the resting experiments, the subjects sat for 6 h in an armchair. A solution containing 100 g of sucrose was ingested at the beginning of the fourth hour during the sucrose experiments. Ingestion of sucrose caused a significant increase in RQ, plasma insulin, blood glucose, lactate and pyruvate in both exercise and rest experiments. Insulin, lactate and pyruvate concentrations rose higher during rest after sucrose ingestion than during exercise. The time courses of the changes in RQ, insulin, glucose, lactate and pyruvate after sucrose ingestion, suggest that glucose entering the cell during rest is immediately oxidized, while during work there is some delay in the oxidation of glucose.
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  • 96
    ISSN: 1432-2013
    Keywords: Insulin ; Muscle Metabolism ; Carbohydrate Metabolism ; “Bis-Phosphoenolpyruvate”
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The time course of the insulin effect on 1,2-bis-phosphoenolpyruvate (bis-PEP), a glucose metabolite, has been investigated. Within 30 sec insulin causes an increase of 60% in the amount of bis-PEP accumulated in incubation media of rat diaphragms.
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  • 97
    ISSN: 1432-1440
    Keywords: long acting glucagon ; glucose ; free fatty acids ; insulin ; left ventricular contractility ; Depot-Glucagon ; Glucosestoffwechsel ; freie Fettsäuren ; Insulin ; linksventriculäre Kontraktilität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zink-Protamin-Glucagon zeigt bei s.c.-Injektion in einer Dosis von 5 mg einen deutlichen, aber protrahierten Anstieg des Blutzuckers um rund 40% innerhalb 1 Std und behält dieses erhöhte Niveau durch mehrere Stunden bei. Die Lipase-Aktivitätssteigerung nach Glucagon ist beim Menschen nur kurzfristig und unbedeutend [rund 7% ige Zunahme der freien Fettsäuren (FFS) 10 min p. inj.], sie wird von einem insulininduzierten Abfall der FFS um rund 50% im Laufe von 6 Std gefolgt. Die Zunahme der Insulinspiegel im Serum ist zwar statistisch signifikant, erreicht aber nicht das Ausmaß der von der intravenösen Verabreichung bekannten Veränderungen. Die hämodynamischen Effekte einer Einzeldosis von 5 mg Zink-Protamin-Glucagon sind nicht eindeutig und lassen lediglich eine nicht signifikante Zunahme von LVdp/dt max um 16,7% nach 15 min erkennen, während alle anderen Parameter im wesentlichen unverändert bleiben. Die mögliche klinische Bedeutung dieser Glucagoneffekte wird diskutiert.
    Notes: Summary The subcutaneous injection of 5 mg of zincprotamine-glucagon results in a 40% increase of blood glucose within 1 hour; this elevated level is maintained for several hours. The activation of lipase after the administration of glucagon in patients is insignificant and of short duration (only 7% rise of plasma FFA 10 minutes after injection) and is followed by an insulin-induced fall of plasma FFA by 50% within 6 hours. There is a concomitant, statistically significant rise in serum insulin. Haemodynamic measurements following a single dose of 5 mg of zinc-protamine-glucagon revealed only a statistically non significant 16.7% rise in LVdp/dt max, after 15 minutes, the other parameters remaining essentially unchanged. The possible elinical significance of these glucagon effects is discussed.
    Type of Medium: Electronic Resource
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  • 98
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 51 (1973), S. 63-67 
    ISSN: 1432-1440
    Keywords: Insulin ; glycaemia ; diabetes ; radioimmunoassay ; Insulin ; Glycaemia ; Diabetes ; Radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Bestimmung des immunoreaktiven Insulins im Plasma hat in der Diagnostik insulinsezernierender Tumoren allgemein Anwendung gefunden. Beim Diabetes mellitus ist diese Untersuchung von großer Bedeutung zur Unterscheidung der metabolischen und pankreatischen Faktoren dieser Krankheit. Sie erleichtert sowohl die Entscheidung in der Wahl der Therapie als auch die weitere Verlaufskontrolle.
    Notes: Summary The use of the measurement of plasma immunoreactive insulin levels is generally accepted for the diagnosis of insulin-secreting tumours. In diabetes, this determination is of major importance for the differentiation between the metabolic and pancreatic factors involved in the disease and it is helpful both for initiating therapy and following up cases over the years.
    Type of Medium: Electronic Resource
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  • 99
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 51 (1973), S. 1010-1015 
    ISSN: 1432-1440
    Keywords: Hemodialysis ; glucose tolerance ; insulin ; Hämodialyse ; Glucosetoleranz ; Insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 39 Dialysepatienten wurden i.v. Glucosetoleranzteste (i.v. GTT) durchgeführt und anhand des AssimilationskoeffizientenK beurteilt. Bei 25 Patienten wurde während des Testes das immunologisch meßbare Insulin (IMI) bestimmt. Bei 5 Patienten und 4 Kontrollpersonen wurden außerdem Insulintoleranzteste (i.v. ITT) durchgeführt. 56% der Patienten wiesen pathologischeK-Werte unter1,2 auf. Eine negative Korrelation zwischenK-Wert und Serumosmolarität konnte nachgewiesen werden. Bei allen Patienten waren die 5- und 10-min Blutzucker-(BZ-)Werte im i.v. GTT in Abhängigkeit des Hämatokrits vermindert. Ebenso waren die Insulinspiegel während des i.v. ITT bei den Patienten vermindert. Aufgrund dieser beiden Befunde ist ein Vergleich der Höhe der Insulinspiegel von Dialysepatienten und Stoffwechselgesunden nicht möglich. Allerdings konnte beobachtet werden, daß bei Patienten mitK〈1,2 die Insulinausschüttung verzögert erfolgte. Beim i.v. ITT fand sich ein verzögerter BZ-Abfall nach der Insulingabe, außerdem war die Halbwertszeit des i.v. applizierten Insulins verlängert. Demnach resultiert die Glucosestoffwechselstörung bei Dialysepatienten aus der Kombination von verlangsamter Insulinausschüttung aus dem Pankreas und verzögerter Insulinwirkung in der Peripherie.
    Notes: Summary In 39 patients undergoing regular hemodialysis treatment (RDT), intravenous glucose tolerance tests (IVGTT) were performed. They were evaluated on the basis of the assimilation coefficient (K-rate). During the tests, immunologically measurable insulin (IMI) was investigated in 25 cases. Intravenous insulin tolerance tests (IVITT) were performed in 5 patients and 4 controls. 56% of the patients showed abnormalK-values (K〈1.2). A negative correlation betweenK-rate and osmolarity could be demonstrated. Depending on the hematocrit, low blood glucose levels were found in all patients 5 and 10 minutes after beginning the IVGTT. Low insulin concentrations during IVITT were also observed. Because of these two findings, a comparison of insulin levels between dialysed patients and normal subjects is not possible. However, the release of insulin was delayed in patients withK-rates lower than 1.2. During IVITT patients on RDT showed a delayed decrease of blood glucose compared to controls, moreover, half-life of i.v. administered insulin was prolonged. It is concluded that the abnormal glucose metabolism in patients on RDT can result from a combination of delayed insulin secretion of the pancreas and delayed peripheral insulin activity.
    Type of Medium: Electronic Resource
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  • 100
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 31 (1973), S. 163-172 
    ISSN: 1439-6327
    Keywords: Muscle Glycogen ; Exercise ; Insulin ; Testosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Anin vitro preparation of electrically stimulated sartorius muscle of the frog was used as a model to investigate the effects of insulin and testosterone on the increased glycogen content of frog skeletal muscle that was observedin vivo 48 h after an exhaustive bout of treadmill exercise. Thein vitro preparation could effectively extract glucose from the bathing medium and continue glycogen synthesis for incubation periods up to 60 h, and the electrical stimulation depleted glycogen by 68%. Electrical stimulation enhanced rates of glucose uptake and glycogen synthesis when these variables were measured after prolonged periods of poststimulation incubation but did not cause an overshoot of glycogen storage similar to that observedin vivo. Stimulation did not produce increments in glycogen synthesis that were additive to those of insulin or testosterone. The absence of glycogen overshoot in thein vitro system may have resulted from the absence of neural factors.
    Type of Medium: Electronic Resource
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