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  • 11
    Electronic Resource
    Electronic Resource
    Editorial (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 807-807 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190324
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  • 12
    Electronic Resource
    Electronic Resource
    Treatment of atypical leishmaniasis with interferon γ resulting in progression of Kaposi's sarcoma in an AIDS patient (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 1041-1047 
    Details
    ISSN: 1432-1440
    Keywords: Acquired immunodeficiency syndrome ; Human immunodeficiency virus ; Leishmania donovanii ; Visceral leishmaniasis ; Kala-azar ; Intestinal pathogens ; Kaposi's sarcoma ; Parasites ; Parasitic pathogens ; Interferon-γ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Visceral leishmaniasis (kala-azar) affecting HIV-infected patient is being reported in increasing frequency. A 40-year-old German bisexual patient with full-blown AIDS is described who presented with Kaposi's sarcoma, epigastric pain, diarrhea, and weight loss but without fever.Leishmania amastigotes were initially found in biopsies from stomach, duodenum, and a cutaneous Kaposi's sarcoma lesion but were later also recovered from bone marrow and lymph node. The patient received three courses of a combination of pentavalent antimony and interferon-γ. In addition to the common side effects such as fever, thrombocytopenia, and elevated amylase and lipase, a vivid progression of the Kaposi's sarcoma was noted. Tumor progression was temporally closely associated with treatment with interferon-γ. Because this phenomemon has also been observed in other patients, we advise caution when using interferon-γ in patients with Kaposi's sarcoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577752
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  • 13
    Electronic Resource
    Electronic Resource
    Recurrent haemolytic uraemic syndrome in a boy with focal and segmental glomerulosclerosis (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 791-792 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959094
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  • 14
    Electronic Resource
    Electronic Resource
    Tubular function and histological findings in ifosfamide-induced renal Fanconi syndrome — a report of two cases (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 384-387 
    Details
    ISSN: 1432-1076
    Keywords: Renal Fanconi syndrome ; Ifosfamide ; Nephrotoxicity ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two patients developed renal Fanconi syndrome (RFS) after intensive long-term chemotherapy for metastatic Ewing sarcoma and disseminated neuroblastoma. Whereas RFS was diagnosed in patient 1 before he developed osteomalacia, patient 2 experienced severe rickets and growth retardation. Renal function studies revealed slight glomerular impairment and severe tubular defects leading to increased excretion of glucose, amino acids, inorganic phosphate and low molecular weight proteins, indicating proximal tubular damage. Patient 2 additionally showed distal tubular dysfunction with acidosis and diminished concentrating capacity. Renal biopsy in patient 1 revealed marked proximal tubular defects without interstitial lymphocytic infiltration. In both patients renal damage could most likely be ascribed to previous ifosfamide (IFOS) therapy. Our patients showed no improvement in renal function after cessation of IFOS treatment, indicating a poor prognosis of once established RFS after IFOS therapy. Measurement of tubular reabsorption capacities provides exact information on the extent of tubular toxicity induced by IFOS and may be used to monitor IFOS treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113264
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  • 15
    Electronic Resource
    Electronic Resource
    Candidiasis visualised by proteinase-directed immunofluorescence (1991)
    Springer
    Virchows Archiv 419 (1991), S. 199-202 
    Details
    ISSN: 1432-2307
    Keywords: Candidiasis ; Secretory proteinase ; Immunofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The secretory aspartic proteinases ofCandida albicans andC. tropicalis are potential factors for virulence produced during infection. By indirect immunofluorescence, we have demonstrated proteinase antigen on elements of both species in deparaffinized tissue sections derived from clinical cases of mucosal and deep-seated candidiasis. Occasionally, we observed a halo of fluorescence in the close vicinity of candidal cells, which may reflect secretion of the enzyme. In kidneys, a ring of amorphous fluorescent material surrounding candidal colonies may illustrate alkaline denaturation of secreted enzyme within a pH gradient, which is generated by the fungus. Our findings support the view that candidal proteinase may be a diagnostically relevant antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01626348
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  • 16
    Electronic Resource
    Electronic Resource
    Simultaneous occurrence of perimembranous glomerulonephritis and glomerular amyloidosis (1978)
    Springer
    Virchows Archiv 378 (1978), S. 315-320 
    Details
    ISSN: 1432-2307
    Keywords: Perimembranous glomerulonephritis ; Glomerular amyloidosis ; Therapy with D-penicillamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The results of electron microscopic examination of renal biopsies from 3 patients with rheumatoid arthritis treated with penicillamine are presented. All 3 patients developed a nephrotic syndrome upon discontinuation of penicillamine therapy. When viewed with the electron microscope, segmental forms of perimembranous glomerulonephritis (Stages I–II of Ehrenreich and Churg) and glomerular renal amyloidosis Grade I–III were observed. In all three cases the nephrotic syndrome was considered to be due to the simultaneous occurrence of the two disease processes. In 2 cases perimembranous glomerulonephritis with immuno-complex-deposits was assumed to be the dominant factor in the causation of the disease, in the other case amyloidosis was the principle abnormality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00465597
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  • 17
    Electronic Resource
    Electronic Resource
    Correlations between the morphological and clinical findings in a patient recovering from secondary generalised amyloidosis with renal involvement (1978)
    Springer
    Virchows Archiv 379 (1978), S. 119-129 
    Details
    ISSN: 1432-2307
    Keywords: Secondary amyloidosis ; Healing of nephrotic syndrome ; Electron microscopic investigations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report light- and electron microscopic findings in glomerular amyloidosis (secondary amyloidosis), which occured after recurrent empyema of the pleura. After healing of the empyema, the clinical symptoms disappeared, over a period of eight years. During the acute stage of the disease (grade II–III amyloidosis) when the nephrotic syndrome was present, amyloid deposits were seen in the mesangium and on both sides of the basement membrane of the glomerular capillaries. Furthermore, denuded basement membrane areas showing the passage of amyloid into the urinary space, and invaginations of the podocyte by straightened amyloid fibrils were found. After clinical recovery (except for a trace of proteinuria), the renal amyloidosis had electronmicroscopically transformed from an active into an inactive or resting form, while the amount of amyloid present was almost the same. In the areas of amyloid deposits, reparative changes were observed, especially in the area of the mesangial cells and of the podocytes. The podocytes were separated from the persisting amyloid deposits by newly formed basement membrane material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432481
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  • 18
    Electronic Resource
    Electronic Resource
    Akutes Nierenversagen Isolierte Manifestation einer Systemerkrankung (1997)
    Springer
    Der Internist 38 (1997), S. 606-609 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Sarkoidose ; Niereninsuffizienz ; Kalziumnephropathie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Eine Sarkoidose der Niere kann isoliert oder im Rahmen einer Systemerkrankung auftreten. Als diagnostisches Leitsymptom dient eine Nierenfunktionsverschlechterung, deren Ursache interstitielle Nephritiden, Glomerulonephritiden oder eine Kalziumnephropathie sein können. Eine Nierenbiopsie ist als wertvolles, differentialdiagnostisches Kriterium frühzeitig indiziert. Störungen des Kalziumstoffwechsels können ebenfalls diagnostisch wegweisend sein. Unter Therapie mit Steroiden kommt es in den meisten Fällen einer Sarkoidose der Niere zu einer guten Restitution der Nierenfunktion. Wesentlich ist, bei einer Niereninsuffizienz unklarer Ätiologie eine Sarkoidose in die differentialdiagnostischen Überlegungen einzubeziehen und frühzeitig mit einer adäquaten Therapie zu beginnen, um Spätschäden zu verhindern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050073
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  • 19
    Electronic Resource
    Electronic Resource
    Effect of furosemide on aminopeptidase activity in the rat kidney and urine (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 852-853 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Histochemische und biochemische Untersuchungen des Verhaltens von Aminopeptidasen nach Furosemidgabe zeigen einen Abfall bzw. Anstieg der Enzymaktivitäten in Nierenschnitten und im Urin von männlichen Wistar-Ratten. Die Resultate weisen auf eine direkte, Furosemid-induzierte reversible Epithelschädigung im proximalen Tubulus hin. Unter gleichen Bedingungen sind entsprechende Befunde bei weiblichen Wistar-Ratten nicht zu erheben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01897917
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  • 20
    Electronic Resource
    Electronic Resource
    Kidney biopsy findings in cyclosporine-treated patients with insulin-dependent diabetes mellitus (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 354-359 
    Details
    ISSN: 1432-1440
    Keywords: Diabetes mellitus ; Cyclosporine ; Toxicity ; Risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal biopsy specimens of 40 patients with recent-onset insulin-dependent diabetes mellitus treated with cyclosporine (CSA) for 6–29 months were examined. Cyclosporine-associated chronic vascular interstitial toxicity of moderate intensity was found in 10 patients (25%). The most prominent lesions were interstitial fibrosis and tubular atrophy. Arteriolopathy was less pronounced and glomerular damage unremarkable. A significant correlation exists between the extent of tubular atrophy and CSA trough whole blood levels. These data indicate that the development of CSA-associated chronic nephropathy is dose-dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02115783
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