Library

X
You have 0 saved results.
Mark results and click the "Add To Watchlist" link in order to add them to this list.
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Local release of eosinophil peroxidase following segmental allergen provocation in asthma (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Eosinophil peroxidase (EPO) is an eosinophilic basic protein, which leads to increased permeability and damage of bronchial epithelial cells in asthma.Objective As little is known about its local expression and release in humans the intracellular expression in lung and peripheral eosinophils and the concentrations of EPO in bronchoalveolar lavage (BAL) fluid and serum was investigated in patients with asthma.Methods Twelve mild atopic asthmatic and nine control subjects underwent segmental sham and allergen challenge. EPO concentrations in BAL fluid and serum were determined by immunoassay and flow cytometry was used to determine the intracellular expression of EPO in BAL-derived and peripheral eosinophils.Results In asthmatic patients a large increase in BAL eosinophils – total cells: median 9.5 × 106 (range: 0.5 to 455.0 × 106); relative: 38% (1 to 91%) – was detectable 24 h following allergen challenge, but peripheral blood eosinophil counts did not change. Concentrations of EPO in BAL fluid increased from 1 µg/L (1.0 to 6.8 µg/L) to 42 µg/L (5.6 to 379.6 µg/L; P 〈 0.01) after allergen but not after saline challenge (1.5 µg/L; 1.0 to 21.9 µg/L), whereas in control subjects all measurements were below the detection limit. Serum concentrations of EPO increased slightly from 18.3 µg/L (3.0 to 56.8 µg/L) to 27 µg/L (3.8 to 133.9 µg/L; P 〈 0.05) 24 h after allergen challenge in asthmatic patients. Furthermore, the intracellular expression of EPO (measured as mean fluorescence intensity) was decreased in BAL eosinophils compared with blood eosinophils (mean fluorescence intensity 29 (7 to 71) vs. 48 (20 to 85); P 〈 0.01) after allergen challenge.Conclusion The finding of increased EPO concentrations in the BAL fluid and decreased intracellular EPO expression in pulmonary eosinophils of asthmatic patients reflects the allergen-triggered release of EPO into the bronchial space.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01580.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Respiratory functions, buffer system, and electrolyte concentrations of blood during human pregnancy
    Amsterdam : Elsevier
    Respiration Physiology 9 (1970), S. 311-317 
    Details
    ISSN: 0034-5687
    Keywords: Arterial blood ; Oxygen pressure Carbon dioxide ; PH Haematocrit ; Pregnancy Haemoglobin ; Standard bicarbonate ; pressure P"5"0 Electrolytes
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0034-5687(70)90088-5
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Leckbeatmung zur Vermeidung von hypoxischen Komplikationen während des tracheobronchialen Absaugens (1972)
    Springer
    Lung 147 (1972), S. 215-219 
    Details
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02100550
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Der Einfluß von Steroidhormonen auf die Diffusionskapazität der Lungen (1973)
    Springer
    Lung 149 (1973), S. 151-155 
    Details
    ISSN: 1432-1750
    Keywords: Corticosteroides ; Diffusing Capacity ; Lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes in the pulmonary diffusing capacity for CO (DlCO) in pregnant women have been reported previously. According to these findings, the effects of various steroid hormones (Oestriol succinate, Progesterone, Prednisolone succinate and Aldactone®) were tested by the single-breath technique of Ogilvie, Forster, Blakemore and Morton. Measurements in ten healthy women were performed one, two and twenty-four hours after intravenous administration of 40 mg Oestriolsuccinat. Significant decreases of 8.8% in the first hour and 12.4% in the second were found. The values normalized within 24 hours. Controls of DlCO were taken 24 and 48 hours after the daily i. m. injection of 50 mg progesterone for two days in ten healthy young women. No change was observed in the first 24 hours. However, there was a slight significant increase of the mean value by 4.2% after 48 hours. The effect of 100 mg Prednisolone succinate and 200 mg Aldactone® were tested because of their great importance in the management of cardiopulmonary diseases. No substance showed an effect on DlCO, one and two hours after intravenous administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151751
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Vergleich hämodynamischer und röntgenologischer Parameter bei Kranken mit chronischem Cor pulmonale (1973)
    Springer
    Lung 149 (1973), S. 127-131 
    Details
    ISSN: 1432-1750
    Keywords: Chronic Cor pulmonale ; Hemodynamics ; Radiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 278 Pat. mit chronischem Cor pulmonale und 44 Kontrollpersonen wurde die Beziehung zwischen linearen Herzmaßen und dem Mitteldruck in der A. pulmonalis untersucht. Das Ergebnis der Berechnungen zeigt, daß allein aufgrund der Breite des Pulmonalsegments bzw. nach dem Querschnitt des R. intermedius der rechten A. pulmonalis eine Schätzung des Pulmonalisdrucks möglich ist. Die Genauigkeit der Vorhersage wird jedoch besser, wenn zusätzlich der Transversaldurchmesser und der Breitendurchmesser des Herzens zur Schätzung herangezogen werden. Im Bereich normaler und leicht bis mäßig erhöhter Pulmonalisdrücke besteht eine Tendenz zur Überschätzung, während die Vorhersage bei stark erhöhten Drücken oft zu niedrige Werte erwarten lassen würde. Durch eine Fehleinschätzung aufgrund der Röntgenmaße entsteht kein klinisch relevanter Irrtum, da bei pathologischen Drücken kaum falsch negative Beurteilungen vorkommen. Nach diesen Befunden ist in der Regel auch bei leichter pulmonaler Hypertonie aufgrund der Röntgenkriterien eine Verdachtsdiagnose möglich.
    Notes: Abstract 278 patients with chronic cor pulmonale caused by obstructive bronchitis or by primary pulmonary hypertension and a controlgroup of 44 patients were examined for mean pulmonary pressures and linear dimensions of heart and major lung vessels taken from roentgenograms. A significant correlation was found between these 2 parameters, indicating the possibility of estimating pulmonary arterial pressure by measuring only the width of the pulmonary segment or the cross-section of the ramus intermedius of the right pulmonary artery. Prediction of pulmonary pressure was most accurate when all measurable diameters of the heart were used for evaluation. With this method, overestimation of pulmonary pressure values was found more often for normal or only slightly elevated them for high pressure ranges, where a tendency to underestimation was noted. There were few false-normal predictions for actually elevated pressures. According to our results it usually on the basis of roentgenologic signs is possible to detect even mild pulmonary hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151748
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Lokalein vivo Dichtebestimmungen der Lunge mit Hilfe der Compton-Streuung (1974)
    Springer
    Lung 150 (1974), S. 345-359 
    Details
    ISSN: 1432-1750
    Keywords: Compton Scatter ; Absolute Lung Density ; Analysis of the Distribution of the Lung Ventilation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird eine Apparatur zur Dichtebestimmung einzelner Lungenabschnittein vivo beschrieben, die auf folgendem Prinzip beruht: Ein ausgeblendeter Strahl vonγ-Quanten einer137Cs-Quelle erfährt beim Durchdringen des Lungengewebes eine Streuung in alle Raumrichtungen. Ein Kollimator sortiert einen Winkelbereich der gestreuten Strahlung aus, wobei der Schnittpunkt zwischen Primärstrahl und Kollimatorachse dem wenige cm3 großen Meßort entspricht. Die in diesen Bereich gestreutenγ-Quanten werden mit einem Szintillationszähler registriert. Die Zählrate hängt von der Dichte des Gewebes am Meßort ab und ermöglicht die Berechnung ihres Absolutwerts. Der Patient liegt während des Meßvorgangs auf einer schwimmenden Platte. Diese läßt sich in alle Raumrichtungen bewegen, wobei der Streuort bei feststehender137Cs-Quelle und fixiertem Kollimator in verschiedene Lungenbereiche verlagert werden kann. Die Zuverlässigkeit des Verfahrens wird mit Modelluntersuchungen demonstriert. Meßbeispiele an Patienten zeigen Anwendungsmöglichkeiten der Apparatur: Es lassen sich Inhomogenitäten der Ventilationsverteilung lokalisieren und quantitativ ausdrücken, wobei es sinnvoll erscheint, das Verhältnis zwischen der lokalen exspiratorischen und der lokalen inspiratorischen Lungendichte als Funktion des Atemzugvolumens bei unterschiedlich tiefen Atemzügen zu betrachten. Wird die schwimmende Platte mit Hilfe eines Motors kontinuierlich fortbewegt, so daß der Meßbereich Gebiete pathologischer Lungenveränderungen durchfährt, dann ergeben sich charakteristische Registrierungen der Zählratenänderung (z. B. für eine Silikose, eine Emphysemblase und eine Atelektase).
    Notes: Abstract An apparatus for assessment of the density of particular portions of the living lung is described. The principle is the following: A collimated beam ofγ-quanta of a137Cs-source penetrating the lung tissue is scattered in all directions. Part of the solid angle of the scatter is sorted out by a collimator, forming an intersection between primary beam and collimator axis of some cm3. Theγ-quanta falling into this angle are registered by a scintillation counter. The count rate depends on the tissue density in the intersection volume and delivers absolute values. During the measuring process the patient is in a supine position on a floating table that is movable in all directions. The intersection volume can be positioned into different portions of the lung,137Cs-source and collimator being fixed. The reliability of the method is demonstrated by phantom measurements. Results with patients show the following capabilities of the apparatus: Inhomogeneities of the ventilation can be localized and expressed in quantitative terms. For this purpose it seems practical to describe the ratio between local lung density in expirium to local lung density in inspirium as a function of the tidal volume for various depths of respiration. Characteristic registrations of the count rate are obtained by moving the patient by means of motor, covering regions of pathologic alterations (e.g. silicosis, emphysema, and atelectasis).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02179339
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Einfluß der Peritonealdialyse auf die Lungenfunktion (1971)
    Springer
    Journal of molecular medicine 49 (1971), S. 484-488 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 10 Patienten mit akutem und chronischem Nierenversagen wurden während einer im Mittel 46 Std dauernden Peritonealdialyse spirographische und blutgasanalytische Untersuchungen sowie Messungen des intraabdominellen Druckes durchgeführt. Bei Verwendung von 2 Liter Spülflüssigkeit kam es während eines Dialysecyclus regelmäßig zu einem Anstieg des intraabdominellen Druckes und zu einem geringfügigen, aber statistisch signifikanten Abfall der Vitalkapazität. Ruheatmung und arterielle Blutgase änderten sich jedoch unter der Erhöhung des intraabdominalen Volumens nicht. Insbesondere kam es während eines Dialysecyclus nicht zu einem Abfall des arteriellen Sauerstoffdruckes. Während der gesamten Dialysedauer veränderten sich die arteriellen Blutgase lediglich entsprechend der Abnahme der vorbestehenden metabolischen Acidose (pCO2-Anstieg, pH-Anstieg). An bronchopulmonalen Komplikationen wurden lediglich in einigen Fällen eine Zunahme bzw. ein Auftreten von Pleuraergüssen beobachtet. Ein Verlassen dieses Verfahrens zugunsten der weniger effektiven Dialyse mit nur 1 Liter Spülflüssigkeit erscheint nicht gerechtfertigt.
    Notes: Summary In ten patients with acute or chronic renal failure, repeated measurements of spirometrics, blood gases and intra-abdominal pressure were performed during peritoncal dialysis. The dialysis lasted 46 hours (mean) with an average exchange volume of 1.9 liter/hour. The two liter fillings caused an increase of the intra-abdominal pressure of 7.5 cm H2O (mean) as compared to empty abdomen and a decrease of the vital capacity of 12.7% (mean) (2p〈0.05). One liter exchanges caused +3.2 cm H2O and −6.8%, respectively. There were no significant changes in the arterial blood gases and in the quiet breathing during the two liter fillings. Blood gases alterations before and after dialysis only showed the expected adaptation to the corrected metabolic acidosis (pCO2 increased from 35.4 Torr to 38.5 Torr and pH from 7.33 to 7.42, while base-excess changed from −7.12 to +0.25 mVal). The only pulmonary complications were, in some cases, the increase or the appearance of pleural effusions. There is no reason to expect that a well controlled peritoneal dialysis with 2-liter cycles should notoriously impend pulmonary functions. We cannot agree with Berlyneet al. (1967) who suggest to abandon this method in favor of the 1-liter cycling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485300
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Malignant mesothelioma of the pleura (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 607-613 
    Details
    ISSN: 1432-1440
    Keywords: Pleural mesothelioma ; Prospective therapeutic study ; Combined modality treatment ; Prognostic variables
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between March 1981 and February 1985, 93 out of 132 patients with a histologically confirmed diagnosis of malignant pleural mesothelioma were eligible for therapy and were prospectively assigned to receive either combined therapy or best supportive care, according to their personal preferences. Fifty-seven patients underwent multimodal therapy including surgical resection where possible, polychemotherapy, and radiation therapy in case of partial remission. Thirty-six patients received maximal supportive care only, as did 39 patients who were not eligible for treatment. The median survival was 13 months for treated patients compared to 7 for those receiving best supportive care and 5 for patients not amenable to treatment. Median progress-free survival was 6, 2, and 1 month respectively. Surgical resection did not prolong life expectancy within the treated group. In view of significant differences in the distribution of various cofactors over the two study groups, stepwise Cox model analyses were performed. Prognostic nontreatment variables related to prolonged survival were: good performance status, stage I and II, absence of chest pain, age below 50 years, and epithelial histology. Although in the Cox model analyses the survival improvement of patients being treated could be greatly attributed to other cofactors, multimodal treatment showed some prolongation of life expectancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728801
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Änderungen der Lungenfunktion nach Timolol-, Metipranolol-, Pindolol- und Pilocarpin-haltigen Augentropfen bei Gesunden und Patienten mit leichtem Asthma bronchiale (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 920-924 
    Details
    ISSN: 1432-1440
    Keywords: β-Receptorblocking Eye-drops ; Bronchial Asthma ; Lung Function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lung function was studied double blind and randomized in 5 patients with mild asthma bronchiale and 10 normal adults before and 30, 60 and 90 minutes after one drop of 0.5% Timolol, 0.6% Metipranolol or 0.9% NaCl in each eye. In the asthmatics bronchoconstriction was seen after both β-receptor blocking agents, more pronounced after Timolol than after Metripranolol. There was a decrease in the forced expiratory volume in one second (FEV1.0) of 32, respectively 18%. No changes were observed in the normal subjects. In a separate studie no significant changes were seen in the mean values of 10 other asthmatic subjects after 1% Pindolol, 3% Pilocarpin or 0.9% NaCl. However, in two patients FEV1.0 was reduced by 15% and 20% of the control values after applying Pindolol. In summary, not only β-receptorblocking agents without ISA produce a bronchoconstriction in asthmatic subjects, but also β-blocker with ISA in individual cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745503
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Localization of the bronchodilator effect induced by type A natriuretic peptide in asthmatic subjects (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 772-774 
    Details
    ISSN: 1432-1440
    Keywords: Type A natriuretic peptide (CDD/ ANP-99-126) ; Bronchodilation ; Asthma therapy ; Lung function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Type A natriuretic peptide (CDD/ANP99-126) in its circulating form was analyzed with respect to the localization of its bronchodilating effects in asthmatic subjects in vivo. The intravenous infusion of 5.7, 11.4, and 17.1 pmol kg−1 min− CDD/ANP-99-126 caused a significant bronchodilation of both central and peripheral airways. While the localization of the bronchodilating effects was similar to β2-agonists, an improvement in lung function parameters comparable to these substances was not observed. But other members of the natriuretic peptide family may reveal a stronger bronchodilating potency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180545
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...