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Material
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Year
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  • 101
    Publication Date: 2014-02-26
    Description: The use of point sets instead of meshes became more popular during the last years. We present a new method for anisotropic fairing of a point sampled surface using an anisotropic geometric mean curvature flow. The main advantage of our approach is that the evolution removes noise from a point set while it detects and enhances geometric features of the surface such as edges and corners. We derive a shape operator, principal curvature properties of a point set, and an anisotropic Laplacian of the surface. This anisotropic Laplacian reflects curvature properties which can be understood as the point set analogue of Taubin's curvature-tensor for polyhedral surfaces. We combine these discrete tools with techniques from geometric diffusion and image processing. Several applications demonstrate the efficiency and accuracy of our method.
    Keywords: ddc:000
    Language: English
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  • 102
    Publication Date: 2020-12-15
    Description: In this paper we introduce the fare planning problem for public transport which consists in designing a system of fares maximizing revenue. We propose a new simple general model for this problem. It i s based on a demand function and constraints for the different fares. The constraints define the structure of the fare system, e.g., distance dependent fares or zone fares. We discuss a simple example with a quadratic demand function and distance dependent fares. Then we introduce a more realistic discrete choice model in which passengers choose between different alternatives depending on the numb er of trips per month. We demonstrate the examples by computational experiments.
    Keywords: ddc:000
    Language: English
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  • 103
    Publication Date: 2020-12-15
    Description: Can OR methods help the public transport industry to break even? The article gives evidence that there exist significant potentials in this direction, which can be harnessed by a combination of modern mathematical methods and local planning knowledge. Many of the planning steps in public transport are classical combinatorial problems, which can be solved in unprecedented size and quality due the rapid progress in large-scale optimization. Three examples on vehicle scheduling, duty scheduling, and integrated vehicle and duty scheduling illustrate the level that has been reached and the improvements that can be achieved today. Extensions of such methods to further questions of strategic, online, and market-oriented planning are currently investigated. In this way, OR can make a significant contribution to answer the basic but extremely difficult question ``What is a good public transport network?.
    Keywords: ddc:000
    Language: English
    Type: reportzib , doc-type:preprint
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  • 104
    Publication Date: 2016-06-09
    Description: Laplace transforms which admit a holomorphic extension to some sector strictly containing the right half plane and exhibiting a potential behavior are considered. A spectral order, parallelizable method for their numerical inversion is proposed. The method takes into account the available information about the errors arising in the evaluations. Several numerical illustrations are provided.
    Keywords: ddc:000
    Language: English
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  • 105
    Publication Date: 2020-03-09
    Description: The airline crew scheduling problem deals with the construction of crew rotations in order to cover the flights of a given schedule at minimum cost. The problem involves complex rules for the legality and costs of individual pairings and base constraints for the availability of crews at home bases. A typical instance considers a planning horizon of one month and several thousand flights. We propose a column generation approach for solving airline crew scheduling problems that is based on a set partitioning model. We discuss algorithmic aspects such as the use of bundle techniques for the fast, approximate solution of linear programs, a pairing generator that combines Lagrangean shortest path and callback techniques, and a novel rapid branching'' IP heuristic. Computational results for a number of industrial instances are reported. Our approach has been implemented within the commercial crew scheduling system NetLine/Crew of Lufthansa Systems Berlin GmbH.
    Keywords: ddc:000
    Language: English
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  • 106
    Publication Date: 2014-03-10
    Description: The complexity of molecular kinetics can be reduced significantly by a restriction to metastable conformations which are almost invariant sets of molecular dynamical systems. With the Robust Perron Cl uster Analysis PCCA+, developed by Weber and Deuflhard, we have a tool available which can be used to identify these conformations from a transition probability matrix. This method can also be applied to the corresponding transition rate matrix which provides important information concerning transition pathways of single molecules. In the present paper, we explain the relationship between these tw o concepts and the extraction of conformation kinetics from transition rates. Moreover, we show how transition rates can be approximated and conclude with numerical examples.
    Keywords: ddc:000
    Language: English
    Type: reportzib , doc-type:preprint
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  • 107
    Publication Date: 2020-03-09
    Description: Die Autoren schreiben dieses Papier aus der eingeschränkten Sicht der Mathematik und der Informationstechnik. Um den speziellen Beitrag dieser Disziplinen überhaupt diskutieren zu können, sehen wir uns jedoch gezwungen, einen Rahmen abzustecken, den wir für das Jahr 2020 vorhersehen -- nach Wahrscheinlichkeit und aus unserem engeren fachlichen Blickwinkel. Vorab bitten wir schon einmal bei den medizinischen Fachleuten um Nachsicht, wenn wir uns in ihrem Revier allzu dillettantisch bewegen. Vielleicht fördert aber auch unser eingeschränkter Blickwinkel ansonsten unbedachte Aspekte zutage -- das hoffen wir zumindest.
    Keywords: ddc:000
    Language: German
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  • 108
    Publication Date: 2014-02-26
    Description: We consider nonlinear, scaling-invariant $N=1$ boson$+$fermion supersymmetric systems whose right-hand sides are homogeneous differential polynomials and satisfy some natural assumptions. We select the super-systems that admit infinitely many higher symmetries generated by recursion operators; we further restrict ourselves to the case when the dilaton dimensions of the bosonic and fermionic super-fields coincide and the weight of the time is half the weight of the spatial variable. We discover five systems that satisfy these assumptions; one system is transformed to the purely bosonic Burgers equation. We construct local, nilpotent, triangular, weakly non-local, and super-recursion operators for their symmetry algebras.
    Keywords: ddc:000
    Language: English
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  • 109
    Publication Date: 2020-12-15
    Description: We present a branch-and-cut algorithm for the NP-hard maximum feasible subsystem problem: For a given infeasible linear inequality system, determine a feasible subsystem containing as many inequalities as possible. The complementary problem, where one has to remove as few inequalities as possible in order to render the system feasible, can be formulated as a set covering problem. The rows of this formulation correspond to irreducible infeasible subsystems, which can be exponentially many. The main issue of a branch-and-cut algorithm for MaxFS is to efficiently find such infeasible subsystems. We present three heuristics for the corresponding NP-hard separation problem and discuss further cutting planes. This paper contains an extensive computational study of our implementation on a variety of instances arising in a number of applications.
    Keywords: ddc:000
    Language: English
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  • 110
    Publication Date: 2014-02-26
    Description: New evolutionary supersymmetric systems whose right-hand sides are homogeneous differential polynomials and which possess infinitely many higher symmetries are constructed. Their intrinsic geometry (symmetries, conservation laws, recursion operators, Hamiltonian structures, and exact solutions) is analyzed by using algebraic methods. A supersymmetric $N=1$ representation of the Burgers equation is obtained. An $N=2$ KdV-component system that reduces to the Burgers equation in the diagonal $N=1$ case $\theta^1=\theta^2$ is found; the $N=2$ Burgers equation admits and $N=2$ modified KdV symmetry. A one\/-\/parametric family of $N=0$ super\/-\/systems that exte nd the Burgers equation is described; we relate the systems within this family with the Burgers equation on associative algebras. A supersymmetric boson$+$fermion representation of the dispersionless Boussinesq equation is investigated. We solve this equation explicitly and construct its integrable deformation that generates two infinite sequences of the Hamiltonians. The Boussinesq equation with dispersion is embedded in a one-parametric family of two-component systems with dissipation. We finally construct a three-parametric supersymmetric system that incorporates the Boussinesq equation with dispersion and dissipation but never retracts to it for any values of the parameters.
    Keywords: ddc:000
    Language: English
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  • 111
    Publication Date: 2014-11-10
    Description: In this paper we present a new technique for computing lower bounds for graph treewidth. Our technique is based on the fact that the treewidth of a graph $G$ is the maximum order of a bramble of $G$ minus one. We give two algorithms: one for general graphs, and one for planar graphs. The algorithm for planar graphs is shown to give a lower bound for both the treewidth and branchwidth that is at most a constant factor away from the optimum. For both algorithms, we report on extensive computational experiments that show that the algorithms give often excellent lower bounds, in particular when applied to (close to) planar graphs.
    Keywords: ddc:000
    Language: English
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  • 112
    Publication Date: 2020-11-13
    Description: Seit einigen Jahren lizenzieren Bibliotheken mit erheblichem finanziellen Aufwand elektronische Zeitschriften. Anders als bei einer Papierausgabe ist der dauerhafte Zugriff auf die bezahlten Dokumente allerdings nicht garantiert: Die e-Zeitschriften liegen auf dem Verlagsserver, und der Verlag schaltet den Zugriff (meist IP-Range des Campus) auf seinem Server frei. Wird der Zugriff von Verlagsseite abgeschaltet, erlöschen sämtliche Zugriffsrechte, auch auf die in der Vergangenheit lizenzierten und bezahlten Zeitschriften. Auf die neuen Abonnementbedingungen hat das Friedrich-Althoff-Konsortium (FAK) reagiert und in seinen Vertr"agen den Erwerb der Archivdaten beim Auslaufen eines Vertrages festgeschrieben. Im Rahmen eines Projektes baut die KOBV-Zentrale einen Zeitschriftenserver auf, um den Zugriff auf die lizenzierten elektronischen Zeitschriften auch nach Ablauf der Lizenzverträge zu gewährleisten. Den Grundstock bilden die vom FAK in den Jahren 1997-2003 lizenzierten elektronischen Zeitschriften der Verlage Kluwer Academic Press, Springer und Elsevier - ein Volumen von rund 1.600 Zeitschriftentiteln mit knapp 1.400.000 Artikeln. Beim Aufbau des Zeitschriftenservers kommt der vertraglich-organisatorischen Komponente eine ebenso wichtige Rolle zu wie der technischen Realisierung. Hier hat die KOBV-Zentrale ein transparentes Verfahren konzipiert und umgesetzt, um für die Verlage die notwendige Vertrauensbasis zu schaffen und gleichzeitig den Einrichtungen ihren berechtigten Zugriff auf die Zeitschriften-Volltexte zu sichern. Die Zeitschriftenartikel werden sowohl im Rahmen des KOBV-Volltextservers, einem neuen Internet-Dienst der KOBV-Zentrale, zugänglich gemacht - volltext-indiziert mit der Suchmaschine Swish-e - als auch integriert in die Metadatensuche und den Open-Linking-Dienst des KOBV-Portals. Während die Metadatenrecherche und die Sicht auf die Abstracts für alle offen sind, ist der Zugriff auf die Artikel-Volltexte auf die an den Verträgen beteiligten Einrichtungen beschränkt. Dazu wurde ein Authentifizierungsverfahren auf der Basis von IP-Ranges eingerichtet. Der vorliegende Text ist die schriftliche Fassung eines gleichnamigen Vortrages auf der ASpB-Tagung 2005 \glqq Spezialbibliotheken zwischen Auftrag und Ressourcen{\grqq} der Arbeitsgemeinschaft der Spezialbibliotheken, die vom 06.-09. September 2005 in der Technischen Universität München stattfand.
    Keywords: ddc:000
    Language: German
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  • 113
    Publication Date: 2014-02-26
    Description: In diesem Bericht wurden Erfahrungen mit der Suchmaschine FAST im Rahmen des Projektes Verteilter Contentspeicher sowie die Suchmaschine FAST beschrieben. Das Ziel des Projektes Verteilter Contentspeicher war die Speicherung, Erschließung und das Angebot der digitalen Bestände der Journale und Dokumente der KOBV-Bibliotheken zu ermöglichen. Die Eignung der Suchmaschine FAST für das Projektvorhaben wurde systematisch und gründlich getestet, indem verschiedene Dokumentmengen mit FAST indexiert wurden.
    Keywords: ddc:000
    Language: German
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  • 114
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    Publication Date: 2020-02-11
    Description: The thesis deals with the implementation and application of out-of-the-box tools in linear and mixed integer programming. It documents the lessons learned and conclusions drawn from five years of implementing, maintaining, extending, and using several computer codes to solve real-life industrial problems. By means of several examples it is demonstrated how to apply algebraic modeling languages to rapidly devise mathematical models of real-world problems. It is shown that today's MIP solvers are capable of solving the resulting mixed integer programs, leading to an approach that delivers results very quickly. Even though, problems are tackled that not long ago required the implementation of specialized branch-and-cut algorithms. In the first part of the thesis the modeling language Zimpl is introduced. Chapter 2 contains a complete description of the language. In the subsequent chapter details of the implementation are described. Both theoretical and practical considerations are discussed. Aspects of software engineering, error prevention, and detection are addressed. In the second part several real-world projects are examined that employed the methodology and the tools developed in the first part. Chapter 4 presents three projects from the telecommunication industry dealing with facility location problems. Chapter 5 characterizes questions that arise in UMTS planning. Problems, models, and solutions are discussed. Special emphasis is put on the dependency of the precision of the input data and the results. Possible reasons for unexpected and undesirable solutions are explained. Finally, the Steiner tree packing problem in graphs, a well-known hard combinatorial problem, is revisited. A formerly known, but not yet used model is applied to combine switchbox wire routing and via minimization. All instances known from the literature are solved by this approach, as are some newly generated bigger problem instances.
    Keywords: ddc:000
    Language: English
    Type: doctoralthesis , doc-type:doctoralThesis
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  • 115
    Publication Date: 2014-02-26
    Description: We develop and experimentally compare policies for the control of a system of $k$ elevators with capacity one in a transport environment with $\ell$ floors, an idealized version of a pallet elevator system in a large distribution center of the Herlitz PBS AG in Falkensee. Each elevator in the idealized system has an individual waiting queue of infinite capacity. On each floor, requests arrive over time in global waiting queues of infinite capacity. The goal is to find a policy that, without any knowledge about future requests, assigns an elevator to each req uest and a schedule to each elevator so that certain expected cost functions (e.g., the average or the maximal flow times) are minimized. We show that a reoptimization policy for minimizing average sq uared waiting times can be implemented to run in real-time ($1\,s$) using dynamic column generation. Moreover, in discrete event simulations with Poisson input it outperforms other commonly used polic ies like multi-server variants of greedy and nearest neighbor.
    Keywords: ddc:000
    Language: English
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  • 116
    Publication Date: 2014-02-26
    Description: A method based on infinite parameter conservation laws is described to factor linear differential operators out of nonlinear partial differential equations (PDEs) or out of differential consequences of nonlinear PDEs. This includes a complete linearization to an equivalent linear PDE (-system) if that is possible. Infinite parameter conservation laws can be computed, for example, with the computer algebra package {\sc ConLaw}.
    Keywords: ddc:000
    Language: English
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  • 117
    Publication Date: 2022-03-11
    Description: Motivated by recent work on integrable flows of curves and 1+1 dimensional sigma models, several $O(N)$-invariant classes of hyperbolic equations $Utx=f(U,Ut,Ux)$ for an $N$-component vector $U(t,x)$ are considered. In each class we find all scaling-homogeneous equations admitting a higher symmetry of least possible scaling weight. Sigma model interpretations of these equations are presented.
    Keywords: ddc:000
    Language: English
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  • 118
    Publication Date: 2014-02-26
    Description: Quadratic Hamiltonians with a linear Lie-Poisson bracket have a number of applications in mechanics. For example, the Lie-Poisson bracket $e(3)$ includes the Euler-Poinsot model describing motion of a rigid body around a fixed point under gravity and the Kirchhoff model describes the motion of a rigid body in ideal fluid. Advances in computer algebra algorithms, in implementations and hardware, together allow the computation of Hamiltonians with higher degree first integrals providing new results in the search for integrable models. A computer algebra module enabling related computations in a 3-dimensional vector formalism is described.
    Keywords: ddc:000
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  • 119
    Publication Date: 2016-06-09
    Description: We give an algorithm to compute $N$ steps of a convolution quadrature approximation to a continuous temporal convolution using only $O(N\, \log N)$ multiplications and $O(\log N)$ active memory. The method does not require evaluations of the convolution kernel, but instead $O(\log N)$ evaluations of its Laplace transform, which is assumed sectorial. The algorithm can be used for the stable numerical solution with quasi-optimal complexity of linear and nonlinear integral and integro-differential equations of convolution type. In a numerical example we apply it to solve a subdiffusion equation with transparent boundary conditions.
    Keywords: ddc:000
    Language: English
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  • 120
    Publication Date: 2014-02-26
    Description: We describe a prototypical framework that further automates system management by composing complex management tasks from elementary actions, and executing composite tasks with feedback-awareness. {\sl FEEDBACKFLOW} implements a general closed control loop of \emph{planning - execution - result validation - replanning}, and generates workflows of system management actions in an adaptive manner. System-dependent behaviour of the loop is specified by declarative description of the domain (essentially descriptions of available actions), and statement of the goal. We evaluate the design of this framework on examples taken from resource construction in Utility Computing environments, and discuss the challenges we have encountered. Our implementation utilizes external components such as \emph{MBP}, a \emph{PDDL}-conform planner, and \emph{Triana}, a workflow specification and execution framework. An alternative approach involving \emph{BPEL4WS} is discussed.
    Keywords: ddc:000
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  • 121
    Publication Date: 2014-02-26
    Description: For a real world problem --- transporting pallets between warehouses in order to guarantee sufficient supply for known and additional stochastic demand --- we propose a solution approach via convex relaxation of an integer programming formulation, suitable for online optimization. The essential new element linking routing and inventory management is a convex piecewise linear cost function that is based on minimizing the expected number of pallets that still need transportation. For speed, the convex relaxation is solved approximately by a bundle approach yielding an online schedule in 5 to 12 minutes for up to 3 warehouses and 40000 articles; in contrast, computation times of state of the art LP-solvers are prohibitive for online application. In extensive numerical experiments on a real world data stream, the approximate solutions exhibit negligible loss in quality; in long term simulations the proposed method reduces the average number of pallets needing transportation due to short term demand to less than half the number observed in the data stream.
    Keywords: ddc:000
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  • 122
    Publication Date: 2014-02-26
    Description: This paper introduces a new algorithm of conformational analysis based on mesh-free methods as described in [M. Weber. Mehless methods in Conformation Dynamics.(2005)]. The adaptive decomposition of the conformational space by softly limiting functions avoids trapping effects and allows adaptive refinement strategies. These properties of the algorithm makes ZIBgridfree particularly suitable for the complete exploration of high-dimensional conformational space. The adaptive control of the algorithm benefits from the tight integration of molecular simulation and conformational analysis. An emphasized part of the analysis is the Robust Perron Cluster Analysis (PCCA+) based on the work of Peter Deuflhard and Marcus Weber. PCCA+ supports an almost-characteristic cluster definition with an outstanding mapping of transition states. The outcome is expressed by the metastable sets of conformations, their thermodynamic weights and flexibility.
    Keywords: ddc:000
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  • 123
    Publication Date: 2021-08-05
    Description: This paper reports on the fourth version of the Mixed Integer Programming Library. Since ({\sc miplib}) is to provide a concise set of challenging problems, it became necessary to purge instances that became too easy. We present an overview of the 27 new problems and statistical data for all 60 instances.
    Keywords: ddc:000
    Language: English
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  • 124
    Publication Date: 2021-02-01
    Description: Der Artikel beschreibt ein mathematisches Optimierungssystem zur Betriebsplanung in großen Wassernetzen, das bei den Berliner Wasserbetrieben eingesetzt wird. Für das Berliner Versorgungsnetz werden Optimierungsergebnisse vorgestellt.
    Keywords: ddc:000
    Language: German
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  • 125
    Publication Date: 2014-02-26
    Description: \\ Zusammenfassung: Der Kooperative Bibliotheksverbund Berlin-Brandenburg (KOBV) betreibt für das KOBV-Portal einen Austausch von Beschreibungen zu elektronischen Ressourcen (Metadaten), der zwisc zwischen verschiedenen Informationsportalen in der Region durchgeführt wird. Die unterschiedlichen Informationsportale verwenden verschiedene Metadaten-Schemata und Austausch-Formate für ihre Ressourcebeschreibungen. Um die Heterogenität der Metadaten zu überwinden, wurde der KOBV-Metadaten-Austausch-Parser (KMA-Parser) entwickelt. Andere Metadaten-Schemata werden auf das KOBV-Metadaten-Schema abgebildet. Der KMA-Parser führt gegebenenfalls eine Format-Transformation durch, konvertiert die Inhalte einzelner Elemente über Konkordanzen und erzeugt neue Metadaten-Elemente aus vorhandenen Feldern. Er validiert den Inhalt auf Vollständigkeit und steuert den Austausch der Metadaten zwischen den Portalen. Der Umwandlungsprozess funktioniert jedoch nicht nur in die Richtung des KOBV-Portals, sondern auch in die entgegengesetzte Richtung. Der Artikel beschreibt die einzelnen Vorgänge im KMA-Parser und schildert die Erfahrungen im Umgang mit der Heterogenität von Metadaten. Die gewonnenen Erfahrungen verweisen auf grundlegende Perspektiven in der universellen Zusammenarbeit von Informationsanbietern und -providern.The Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV) has built a framework for a bi-directional exchange workflow of electronic resourcesÆ descriptions (metadata) between the KOBV Portal and other Information Portals in the region. The Information Portals use different exchange formats, metadata schemata and controlled vocabularies for their descriptions of resources. In order to overcome this metadata heterogeneity, an application, the KOBV Metadata Exchange Parser (KMA-Parser), has been developed. The KMA-Parser maps the local portalsÆ metadata schemata into the metadata schema of the KOBV Portal. If necessary, it transforms the exchange format, converts contents of individual elements by means roduces new metadata elements on the basis of existent elements. It checks elementsÆ contents on completeness and controls the metadata exchange between the portals. However, the transformation process takes place not only towards the KOBV Portal, but al so vice versa. The article describes the individual processes in the KMA Parser and depicts the experiences in handling the metadataÆs heterogeneity. The experiences gathered give an idea of the prospects for a universal cooperation between information suppliers and providers.
    Keywords: ddc:000
    Language: German
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  • 126
    Publication Date: 2021-01-22
    Description: \newcommand{\chordsharp}{Chord$^\##$} Data lookup is a fundamental problem in peer-to-peer systems: Given a key, find the node that stores the associated object. Chord and other P2P algorithms use distributed hash tables (DHTs) to distribute the keys and nodes evenly across a logical ring. Using an efficient routing strategy, DHTs provide a routing performance of $O (\log N)$ in networks of $N$ nodes. While the routing performance has been shown to be optimal, the uniform key distribution makes it impossible for DHTs to support range queries. For range queries, consecutive keys must be stored on lo gically neighboring nodes. In this paper, we present an enhancement of Chord that eliminates the hash function while keeping the same routing performance. The resulting algorithm, named \chordsharp{}, provides a richer function ality while maintaining the same complexity. In addition to Chord, \chordsharp{} adapts to load imbalance.
    Keywords: ddc:000
    Language: English
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  • 127
    Publication Date: 2019-01-29
    Description: This paper is concerned with the sensitivities of function space oriented interior point approximations in parameter dependent problems. For an abstract setting that covers control constrained optimal control problems, the convergence of interior point sensitivities to the sensitivities of the optimal solution is shown. Error bounds for $L_q$ norms are derived and illustrated with numerical examples.
    Keywords: ddc:000
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  • 128
    Publication Date: 2020-08-05
    Description: We present an approach to implement an auction of railway slots. Railway network, train driving characteristics, and safety requirements are described by a simplified, but still complex macroscopic model. In this environment, slots are modelled as combinations of scheduled track segments. The auction design builds on the iterative combinatorial auction. However, combinatorial bids are restricted to some types of slot bundles that realize positive synergies between slots. We present a bidding language that allows bidding for these slot bundles. An integer programming approach is proposed to solve the winner determination problem of our auction. Computational results for auction simulations in the Hannover-Fulda-Kassel area of the German railway network give evidence that auction approaches can induce a more efficient use of railway capacity.
    Keywords: ddc:000
    Language: English
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  • 129
    Publication Date: 2014-02-26
    Description: Das Travelling-Salesman-Problem (TSP) ist das am intensivsten untersuchte kombinatorische Optimierungsproblem. In diesem Abschnitt wird eine Einführung in das TSP gegeben. Es werden Problemstellungen erläutert, Anwendungen skizziert und einige Schwierigkeiten bei der korrekten Modellierung der Zielfunktion dargelegt. Es ist gar nicht so klar, was in einem konkreten Problem die wirkliche Entfernung ist. Exakte und approximative Lösungsverfahren werden an Beispielen skizziert, und es wird angedeutet, dass man, obwohl TSPs zu den theoretisch schweren Problemen zählen, in der Praxis TSPs von atemberaubender Größe lösen kann.
    Keywords: ddc:000
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  • 130
    Publication Date: 2014-02-26
    Description: Mit der Installation des neuen Hochleistungsrechners für die norddeutschen Länder (HLRN) steht den Wissenschaftlern ein außergewöhnlich leistungsfähiges System zur Verfügung. Durch die Verteilung der Rechenelemente auf zwei verschiedene Standorte in Berlin (ZIB) und Hannover (RRZN) entstehen jedoch auch neue Herausforderungen für den Betrieb und die effiziente Nutzung des Rechners. Inhalt dieses Projektes ist die Erforschung und Lösung der durch die Verteilung des Systems hervorgerufenen Probleme (z.B. Scheduling, Kommunikation, I/O). Es werden effiziente Lösungen zur Bereitstellung eines virtuellen, hoch-performanten und transparenten Systems entwickelt, die auf vergleichbare Installationen übertragbar sind.
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  • 131
    Publication Date: 2014-11-10
    Description: We study the complexity of two Inverse Shortest Paths (ISP) problems with integer arc lengths and the requirement for uniquely determined shortest paths. Given a collection of paths in a directed graph, the task is to find positive integer arc lengths such that the given paths are uniquely determined shortest paths between their respective terminals. The first problem seeks for arc lengths that minimize the length of the longest of the prescribed paths. In the second problem, the length of the longest arc is to be minimized. We show that it is $np-hard$ to approximate the minimal longest path length within a factor less than $8/7$ or the minimal longest arc length within a factor less than $9/8$. This answers the (previously) open question whether these problems are $np-hard$ or not. We also present a simple algorithm that achieves an $\mathcal{O}(|V|)$-approximation guarantee for both variants. Both ISP problems arise in the planning of telecommunication networks with shortest path routing protocols. Our results imply that it is $\mathcal{NP}$-hard to decide whether a given path set can be realized with a real shortest path routing protocol such as OSPF, IS-IS, or RIP.
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  • 132
    Publication Date: 2014-02-26
    Description: We perform a classification of integrable systems of mixed scalar and vector evolution equations with respect to higher symmetries. We consider polynomial systems that are homogeneous under a suitable weighting of variables. This paper deals with the KdV weighting, the Burgers (or potential KdV or modified KdV) weighting, the Ibragimov--Shabat weighting and two unfamiliar weightings. The case of other weightings will be studied in a subsequent paper. Making an ansatz for undetermined coefficients and using a computer package for solving bilinear algebraic systems, we give the complete lists of $2^{\mbox{\scriptsize nd }}$order systems with a $3^{\mbox{\scriptsize rd }}$order or a $4^{\mbox{\scriptsize th }}$order symmetry and $3^{\mbox{\scriptsize rd }}$order systems with a $5^{\mbox{\scriptsize th }}$order symmetry. For all but a few systems in the lists, we show that the system (or, at least a subsystem of it) admits either a Lax representation or a linearizing transformation. A thorough comparison with recent work of Foursov and Olver is made.
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  • 133
    Publication Date: 2014-02-26
    Description: The result after $N$ steps of an implicit Runge-Kutta time discretization of an inhomogeneous linear parabolic differential equation is computed, up to accuracy $\varepsilon$, by solving only $$O\Big(\log N\, \log \frac1\varepsilon \Big) $$ linear systems of equations. We derive, analyse, and numerically illustrate this fast algorithm.
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  • 134
    Publication Date: 2020-11-13
    Description: In this paper, we study wavelength assignment problems in multi-fiber WDM networks. We focus on the special case that all lightpaths have at most two links. This in particular holds in case the network topology is a star. As the links incident to a specific node in a meshed topology form a star subnetwork, results for stars are also of interest for general meshed topologies. We show that wavelength assignment with at most two links per lightpath can be modeled as a generalized edge coloring problem. By this relation, we show that for a network with an even number of fibers at all links and at most two links per lightpath, all lightpaths can be assigned a wavelength without conversion. Moreover, we derive a lower bound on the number of lightpaths to be converted for networks with arbitrary numbers of fibers at the links. A comparison with linear programming lower bounds reveals that the bounds coincide for problems with at most two links per lightpath. For meshed topologies, the cumulative lower bound over all star subnetworks equals the best known solution value for all realistic wavelength assignment instances available, by this proving optimality.
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  • 135
    Publication Date: 2014-11-21
    Description: We prove that the Random-Edge simplex algorithm requires an expected number of at most $13n/sqrt(d)$ pivot steps on any simple d-polytope with n vertices. This is the first nontrivial upper bound for general polytopes. We also describe a refined analysis that potentially yields much better bounds for specific classes of polytopes. As one application, we show that for combinatorial d-cubes, the trivial upper bound of $2^d$ on the performance of Random-Edge can asymptotically be improved by any desired polynomial factor in d.
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  • 136
    Publication Date: 2014-11-10
    Description: In diesem Artikel werden die Optimierungsmodelle und -verfahren beschrieben, die bei der Planung des Kernnetzes und der Zugangsinfrastruktur des X-WiN verwendet wurden.
    Keywords: ddc:000
    Language: German
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  • 137
    Publication Date: 2014-02-26
    Description: Die Anwendung mathematischer Methoden und Verfahren wird immer mehr zur Voraussetzung innovativer Produkte und Dienstleistungen. Um neue Produkte und Dienstleistungen zu entwickeln, müssen die Produktions- und technologischen Prozesse mathematisch modelliert, beschrieben und optimiert werden. Diesen Umstand Rechnung tragend, hat das Bundesministerium für Bildung und Forschung (BMBF) 1993 begonnen, den Einsatz mathematischer Verfahren und Methoden in der Mathematik über ein spezielles Mathematikprogramm zu fördern. Inzwischen hat die vierte Förderperiode des Mathematikprogramms begonnen. \par Das Medium Internet und insbesondere das WWW sind für die Sichtbarkeit und Transparenz wissenschaftlicher Resultate in den letzten zehn Jahren immer wichtiger geworden. Wer nicht im Web "'sichtbar"' ist, läuft Gefahr, nicht wahrgenommen zu werden. Intention und Ziel des durchgeführten Projekts war es, ein Konzept für eine qualitativ hochwertige und umfassende Darstellung des BMBF Mathematikprogramms, insbesondere der in den Projekten erzielten Ergebnisse, zu entwickeln und zu realisieren und damit den Stellenwert und die Akzeptanz mathematischer Forschung in der Gesellschaft zu festigen und den Wissenstransfer zwischen mathematischer Forschung sowie Forschung und Entwicklung in der Wirtschaft und dem Dienstleistungsbereich zu fördern.
    Keywords: ddc:000
    Language: German
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  • 138
    Publication Date: 2014-02-26
    Description: Die KOBV-Zentrale betreibt mit dem KOBV-Portal neben der Metasuche in freien Online-Katalogen und Datenbanken ein Nachweisinstrument für elektronische Ressourcen, die von den Bibliotheken Berlin-Brandenburgs lizenziert sind und darüber hinaus diejenigen, die frei zugänglich sowie wissenschaftlich relevant sind. Die Erschließung der freien Ressourcen übernimmt eine kooperative Fachredaktion, die sich aus FachreferentInnen und -lektorInnen aus der Region rekrutiert. Dabei übernimmt jede beteiligte Person die Betreuung einer oder mehrerer Fachgruppen der Dewey Decimal-Classification (DDC) eigenverantwortlich. Die Aufgabe aller FachredakteurInnen besteht in der inhaltlichen Beschreibung, der Klassifizierung, der Vergabe von Schlagworten und der regelmäßigen Reevaluation der einzelnen Ressourcen. Die KOBV-Zentrale hat hierfür einen Kriterienkatalog entwickelt, der als Grundlage für die Beurteilung von elektronischen Ressourcen dient. Erschlossen werden die Ressourcen schließlich über ein webbasierte Eingabe-Tool, dem Metadata-Tool der KOBV-Zentrale. Über eine Mailingliste wird der Abstimmungsbedarf untereinander gedeckt und Diskussionen geführt, die das Projekt weiterführen sollen. Der Artikel beschreibt das Konzept der kooperativen Fachredaktion für freie Ressourcen, die Vorgänge und die Arbeiten, die für die Initiierung notwendig waren.
    Keywords: ddc:000
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  • 139
    Publication Date: 2014-02-26
    Description: We present a new algorithm for fairing of space curves with respect spatial constraints based on a vector valued curvature function. Smoothing with the vector valued curvature function is superior to standard Frenet techniques since the individual scalar components can be modeled similar to curvature-based curve smoothing techniques in 2d. This paper describes a curve smoothing flow that satisfies strict spatial constraints and allows simultaneous control of both curvature functions.
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  • 140
    Publication Date: 2016-06-09
    Description: Scattering problems in integrated optics can be modeled in simple cases by the Helmholtz equation. The computational domain is truncated by a non-reflecting boundary condition. We investigate Schwarz algorithms with a sort of DtN operator, realized by the PML-method, at the interfaces of the sub-domains as an iterative solver.
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  • 141
    Publication Date: 2019-05-10
    Description: Adaptive numerical methods in space and time are introduced and studied for multiscale cardiac reaction-diffusion models in three dimensions. The evolution of a complete heartbeat, from the excitation to the recovery phase, is simulated with both the anisotropic Bidomain and Monodomain models, coupled with either a variant of the simple FitzHugh-Nagumo model or the more complex phase-I Luo-Rudy ionic model. The simulations are performed with the {\sc kardos} library, that employs adaptive finite elements in space and adaptive linearly implicit methods in time. The numerical results show that this adaptive method successfully solves these complex cardiac reaction-diffusion models on three-dimensional domains of moderate sizes. By automatically adapting the spatial meshes and time steps to the proper scales in each phase of the heartbeat, the method accurately resolves the evolution of the intra- and extra-cellular potentials, gating variables and ion concentrations during the excitation, plateau and recovery phases.
    Keywords: ddc:000
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  • 142
    Publication Date: 2021-02-01
    Description: Mathematical decision support for operative planning in water supply systems is highly desirable but leads to very difficult optimization problems. We propose a nonlinear programming approach that yields practically satisfactory operating schedules in acceptable computing time even for large networks. Based on a carefully designed model supporting gradient-based optimization algorithms, this approach employs a special initialization strategy for convergence acceleration, special minimum up and down time constraints together with pump aggregation to handle switching decisions, and several network reduction techniques for further speed-up. Results for selected application scenarios at Berliner Wasserbetriebe demonstrate the success of the approach.
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  • 143
    Publication Date: 2014-02-26
    Description: The theory of hierarchical Boolean satisfiability (SAT) solving proposed in this paper is based on a strict axiomatic system and introduces a new important notion of implicativity. The theory makes evident that increasing implicativity is the core of SAT-solving. We provide a theoretical basis for increasing the implicativity of a given SAT instance and for organizing SAT-solving in a hierarchical way. The theory opens a new domain of research: SAT-model construction. Now quite different mathematical models can be used within practical SAT-solvers. The theory covers many advanced techniques such as circuit-oriented SAT-solving, mixed BDD/CNF SAT-solving, merging gates, using pseudo-Boolean constraints, using state machines for representation of Boolean functions, arithmetic reasoning, and managing don t cares. We believe that hierarchical SAT-solving is a cardinal direction of research in practical SAT-solving.
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  • 144
    Publication Date: 2020-12-15
    Description: The \emph{fare planning problem} for public transport is to design a system of fares that maximize the revenue. We introduce a nonlinear optimization model to approach this problem. It is based on a d iscrete choice logit model that expresses demand as a function of the fares. We illustrate our approach by computing and comparing two different fare systems for the intercity network of the Netherlands.
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  • 145
    Publication Date: 2020-12-15
    Description: The line planning problem is one of the fundamental problems in strategic planning of public and rail transport. It consists in finding lines and corresponding frequencies in a network such that a giv en demand can be satisfied. There are two objectives. Passengers want to minimize travel times, the transport company wishes to minimize operating costs. We investigate three variants of a multi-commo dity flow model for line planning that differ with respect to passenger routings. The first model allows arbitrary routings, the second only unsplittable routings, and the third only shortest path rou tings with respect to the network. We compare these models theoretically and computationally on data for the city of Potsdam.
    Keywords: ddc:000
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  • 146
    Publication Date: 2020-11-13
    Description: \documentclass[12pt]{article} \usepackage{german} \parindent=0pt \begin{document} Im KOBV wird für die Online-Fernleihe der Zentrale-Fernleihserver (ZFL-Server) der Firma Sisis eingesetzt. Die Software ist in der KOBV-Zentrale installiert. Der ZFL-Server dient im KOBV sowohl für die Bestellung von Monographien als auch für die Bestellung von Aufsatzkopien aus Zeitschriften. Prinzipiell gibt es zwei Verfahren, mit denen sich Bibliotheken an der Online-Fernleihe beteiligen können: das E-Mail-Verfahren und das SLNP-Verfahren. Auf beide wird im Handbuch eingegangen. Die Online-Fernleihe wurde im KOBV eingeführt, um die Fernleihe für die Benutzer zu beschleunigen, das Verfahren für die Bibliotheksmitarbeiter zu vereinfachen und den Arbeitsaufwand zu reduzieren. Sie basiert darauf, dass eine Bestellung anhand eines gefundenen Treffers ausgelöst wird - d.h. die bibliographischen Daten sind bereits verifiziert und in einem Katalog nachgewiesen. Anschlie\"send werden die Fernleihbestellungen über den ZFL-Server automatisch ausgeführt und verwaltet - sowohl in der regionalen KOBV-Fernleihe als auch in der verbundübergreifenden Fernleihe mit den deutschen Bibliotheksverbünden. Der ZFL-Server besteht aus verschiedenen technischen Komponenten. Eine dieser Komponenten ist das Bibliothekskonto, eine Internetanwendung, in der die Bestellverwaltung des ZFL-Servers im Internet für die Bibliotheksbediensteten transparent gemacht wird. Sowohl für die aktive als auch für die passive Fernleihe ist im Bibliothekskonto der Status der Bearbeitung zu jedem Zeitpunkt ersichtlich, z.B. in welcher Bibliothek sich die Bestellung gerade befindet, wann sie dort eingegangen ist und wann sie weggeschickt wurde, ob mit positivem oder negativem Ergebnis. Das Bibliothekskonto ist damit für die Bibliothek ein komfortables Instrument zum Überwachen der Fernleihbestellungen, in dem sie zudem - falls notwendig - in den Bestellvorgang eingreifen kann. Dazu hat jede Bibliothek im Bibliothekskonto eine eigene, Passwort-geschützte Dienstoberfläche. Das vorliegende Handbuch beschreibt die Vorgänge der Bestellverwaltung im Bibliothekskonto. Es richtet sich an Bibliotheksmitarbeiter, die sich mit den einzelnen Arbeitsschritten der Online-Fernleihe vertraut machen wollen. Darüber hinaus ist es zum Nachschlagen gedacht, wenn sich in der täglichen Arbeit Unklarheiten ergeben. \end{document}
    Keywords: ddc:000
    Language: German
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  • 147
    Publication Date: 2022-03-14
    Description: The Feasibility Pump of Fischetti, Glover, Lodi, and Bertacco has proved to be a very successful heuristic for finding feasible solutions of mixed integer programs. The quality of the solutions in terms of the objective value, however, tends to be poor. This paper proposes a slight modification of the algorithm in order to find better solutions. Extensive computational results show the success of this variant: in 89 out of 121 MIP instances the modified version produces improved solutions in comparison to the original Feasibility Pump.
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  • 148
    Publication Date: 2014-02-26
    Description: In this letter we report on a numerical investigation of the Aoki phase in the case of finite temperature which continues our former study at zero temperature. We have performed simulations with Wilson fermions at $\beta=4.6$ using lattices with temporal extension $N_{\tau}=4$. In contrast to the zero temperature case, the existence of an Aoki phase can be confirmed for a small range in $\kappa$ at $\beta=4.6$, however, shifted slightly to lower $\kappa$. Despite fine-tuning $\kappa$ we could not separate the thermal transition line from the Aoki phase.
    Keywords: ddc:000
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  • 149
    Publication Date: 2021-02-01
    Description: The dynamics of pressurized water distribution networks are naturally modeled by differential algebraic equations (DAE). This paper investigates fundamental structural properties of such a DAE model under weak regularity assumptions. The usual partial derivative-based index-1 condition is shown to be necessary and sufficient for several index concepts, as well as sufficient for solvability in a strong sense. Using the physical properties of nonlinear network elements and the inherent saddle point structure of network hydraulics, we then derive purely topological index criteria based on the network graph and the choice of control variables. Several examples illustrate the theoretical results and explore different non-index-1 situations. A brief discussion of the implications for operative planning by discrete time DAE boundary value problems concludes the paper.
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  • 150
    Publication Date: 2020-02-11
    Description: Using the popular puzzle game of Sudoku, this article highlights some of the ideas and topics covered in ZR-04-58.
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  • 151
    Publication Date: 2021-03-16
    Description: Perfect graphs constitute a well-studied graph class with a rich structure, reflected by many characterizations with respect to different concepts. Perfect graphs are, for instance, precisely those graphs $G$ where the stable set polytope $STAB(G)$ coincides with the fractional stable set polytope $QSTAB(G)$. For all imperfect graphs $G$ it holds that $STAB(G) \subset QSTAB(G)$. It is, therefore, natural to use the difference between the two polytopes in order to decide how far an imperfect graph is away from being perfect; we discuss three different concepts, involving the facet set of $STAB( G)$, the disjunctive index of $QSTAB(G)$, and the dilation ratio of the two polytopes. Including only certain types of facets for $STAB(G)$, we obtain graphs that are in some sense close to perfect graphs, for example minimally immperfect graphs, and certain other classes of so-called rank-perfect graphs. The imperfection ratio has been introduced by (Gerke and McDiarmid, 2001) as the dilation ratio of $STAB(G)$ and $QSTAB(G)$, whereas (Aguilera et al., 2003) suggest to take the disjunctive index of $Q STAB(G)$ as the imperfection index of $G$. For both invariants there exist no general upper bounds, but there are bounds known for the imperfection ratio of several graph classes (Coulonges et al. 2005, Gerke and McDiarmid, 2001). Outgoing from a graph-theoretical interpretation of the imperfection index, we conclude that the imperfection index is NP-hard to compute and we prove that there exists no upper bound on the imperfect ion index for those graph classes with a known bounded imperfection ratio. Comparing the two invariants on those classes, it seems that the imperfection index measures imperfection much more roughly than the imperfection ratio; therefoe, discuss possible directions for refinements.
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  • 152
    Publication Date: 2020-11-13
    Description: Many online problems encountered in real-life involve a two-stage decision process: upon arrival of a new request, an irrevocable first-stage decision (the assignment of a specific resource to the request) must be made immediately, while in a second stage process, certain ``subinstances'' (that is, the instances of all requests assigned to a particular resource) can be solved to optimality (offline) later. We introduce the novel concept of an \emph{Online Target Date Assignment Problem} (\textsc{OnlineTDAP}) as a general framework for online problems with this nature. Requests for the \textsc{OnlineTDAP} become known at certain dates. An online algorithm has to assign a target date to each request, specifying on which date the request should be processed (e.\,g., an appointment with a customer for a washing machine repair). The cost at a target date is given by the \emph{downstream cost}, the optimal cost of processing all requests at that date w.\,r.\,t.\ some fixed downstream offline optimization problem (e.\,g., the cost of an optimal dispatch for service technicians). We provide general competitive algorithms for the \textsc{OnlineTDAP} independently of the particular downstream problem, when the overall objective is to minimize either the sum or the maximum of all downstream costs. As the first basic examples, we analyze the competitive ratios of our algorithms for the par ticular academic downstream problems of bin-packing, nonpreemptive scheduling on identical parallel machines, and routing a traveling salesman.
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  • 153
    Publication Date: 2022-07-19
    Description: Inhalt dieser Diplomarbeit ist ein Beleuchtungs- und Visualisierungsmodell für Pflanzen im interaktiven Landschaftsrendering. Ziel ist die qualitativ hochwertige Darstellung von einzelnen Individuen nahe des Betrachters, der seine Position in einer ansonsten statischen Szene frei wählen kann. Um dies zu erreichen wird zunächst vorgestellt, wie ausgehend von einfachen 3D-Modellen und Materialien ein physikalisch basiertes Reflexionsmodell parametrisiert werden kann. Grund hierfür ist der oftmals vorhandene umfangreiche Datenbestand, der auf die OpenGL-Materialien oder ähnliche Shader optimiert ist. Anschließend wird gezeigt, wie die Echtzeit-Renderingtechniken Shadow Mapping und Precomputed Radiance Transfer kombiniert werden können, um sowohl exakte hochfrequente direkte Beleuchtung als auch niederfrequentes indirektes Streulicht zu berücksichtigen. Diese Kombination wird an Hand der Pfad-Notation des Monte-Carlo-Path-Tracing eingeführt und begründet.
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    Language: German
    Type: masterthesis , doc-type:masterThesis
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  • 154
    Publication Date: 2024-02-09
    Description: Die hierarchische Organisation von Dateien beherrscht Computersysteme seit vielen Jahren und wird sich vermutlich auch in Zukunft weiterhin durchsetzen. Dennoch stößt diese Verwaltungsmethode in einem klassischen hierarchischen Dateisystem bei dem jährlichen rasanten Zuwachs an neuen Daten an ihre Grenzen, auch wenn Nutzer eine ausgefeilte Verzeichnisstruktur mit einer disziplinierten Namensgebung konsequent auf- und ausbauen. Um den Überblick über die Dateien zu behalten, werden in dieser Arbeit neue Verwaltungsmethoden vorgestellt und in die hierarchische Dateisystemsicht eingebettet. Auf der Basis des hierarchischen Dateisystems bietet ein metadatenbasiertes Dateisystem neben dem hierarchischen Zugriff noch einen flexiblen, assoziativen Zugriff auf Dateien über virtuelle Objekte, indem Suchmethoden in Form einer Anfrage auf in einer Datenbank gespeicherte Index- und Metadaten angewendet werden. Das Ergebnis dieser Abfrage wird mit Hilfe von virtuellen Verzeichnissen und virtuellen Dateien in einer übersichtlichen Form dargestellt, so dass eine Nutzung der hierarchischen Sicht weiterhin intuitiv fortgesetzt wird. Das Datenmanagementsystem ZIBDMS, welches einen verteilten Metadatenkatalog und einen Dateireplikationskatalog beinhaltet, ermöglicht es, die oben genannten Verwaltungsmethoden für die NFS-Schnittstelle, CORBA-Middleware und Web Services transparent zu implementieren. Zudem stellt ZIBDMS weitere neue Dateiverwaltungsmethoden zur Verfügung, die sich in die hierarchische Dateisystemsicht integrieren lassen. Metadaten in Form von Attribut-Wert-Paaren lassen sich als virtuelle Datei darstellen und editieren. Eine Collection bietet die Möglichkeit, Dateien in einem logischen virtuellen Ordner zu organisieren. Mit einem Dependency-Graph lassen sich Dateien zueinander in Relation stellen, so dass eine Linkstruktur zwischen Dateien ausgedrückt werden kann. Das Verweiskonzept eines klassischen hierarchischen Dateisystems wird im ZIBDMS um eine neue Verweisart Weak-Link erweitert, um einen aktualisierbaren, konsistenten und zyklenfreien symbolischen Link anzubieten. In einer hierarchischen Sicht lässt sich durch Verweise ein Baum bilden, in dem eine Navigation und Verweisauflistung möglich sind, was außer ZIBDMS noch kein anderes System bietet.
    Description: The hierarchical organization of files has dominated computer systems for many years and this will probably not change in the near future. However, with the rapid annual growth of new data this classical hierarchical file system management method reaches its limitations, even when the user consistently sets up and continually expands an elaborated directory structure with well-disciplined naming. This paper introduces new management methods to maintain an overview of all files which can be embedded in the hierarchical file system. A metadata-based file system, which is based on the hierarchical file system, offers, in addition to hierarchical access, a more flexible and associative access to files via virtual objects by providing query capabilities of index- and metadata which are stored in a database. The query results are presented in a clearly-arranged form of virtual directories and virtual files so that the intuitive hierarchical view continues to be maintained. The data management system ZIBDMS, which contains a distributed metadata catalog and a file replication catalog, permits a transparent implementation of these management methods for the NFS interface, CORBA-middleware or web services. Furthermore, ZIBDMS provides other new file management methods that can be integrated into the hierarchical file system view. Metadata in form of attribute-value-pairs can be presented and edited with a virtual file. A Collection makes it possible to organize files in logical virtual folders. Using a Dependency graph, files can be related to each other and expressed through a link structure between these files. In the ZIBDMS the reference concept of a classical hierarchal file system is extended with a new kind of reference called Weak Link in order to provide up-to-date, consistent and cycle-free symbolic links. With the references a tree can be established in a hierarchical view in which navigation and listing of references are possible; this capability is only possible in the ZIBDMS system.
    Keywords: ddc:000
    Language: German
    Type: reportzib , doc-type:preprint
    Format: application/pdf
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  • 155
    Publication Date: 2024-02-09
    Description: Die hierarchische Organisation von Dateien beherrscht Computersysteme seit vielen Jahren und wird sich vermutlich auch in Zukunft weiterhin durchsetzen. Dennoch stößt diese Verwaltungsmethode in einem klassischen hierarchischen Dateisystem bei dem jährlichen rasanten Zuwachs an neuen Daten an ihre Grenzen, auch wenn Nutzer eine ausgefeilte Verzeichnisstruktur mit einer disziplinierten Namensgebung konsequent auf- und ausbauen. Um den Überblick über die Dateien zu behalten, werden in dieser Arbeit neue Verwaltungsmethoden vorgestellt und in die hierarchische Dateisystemsicht eingebettet. Auf der Basis des hierarchischen Dateisystems bietet ein metadatenbasiertes Dateisystem neben dem hierarchischen Zugriff noch einen flexiblen, assoziativen Zugriff auf Dateien über virtuelle Objekte, indem Suchmethoden in Form einer Anfrage auf in einer Datenbank gespeicherte Index- und Metadaten angewendet werden. Das Ergebnis dieser Abfrage wird mit Hilfe von virtuellen Verzeichnissen und virtuellen Dateien in einer übersichtlichen Form dargestellt, so dass eine Nutzung der hierarchischen Sicht weiterhin intuitiv fortgesetzt wird. Das Datenmanagementsystem ZIBDMS, welches einen verteilten Metadatenkatalog und einen Dateireplikationskatalog beinhaltet, ermöglicht es, die oben genannten Verwaltungsmethoden für die NFS-Schnittstelle, CORBA-Middleware und Web Services transparent zu implementieren. Zudem stellt ZIBDMS weitere neue Dateiverwaltungsmethoden zur Verfügung, die sich in die hierarchische Dateisystemsicht integrieren lassen. Metadaten in Form von Attribut-Wert-Paaren lassen sich als virtuelle Datei darstellen und editieren. Eine Collection bietet die Möglichkeit, Dateien in einem logischen virtuellen Ordner zu organisieren. Mit einem Dependency-Graph lassen sich Dateien zueinander in Relation stellen, so dass eine Linkstruktur zwischen Dateien ausgedrückt werden kann. Das Verweiskonzept eines klassischen hierarchischen Dateisystems wird im ZIBDMS um eine neue Verweisart Weak-Link erweitert, um einen aktualisierbaren, konsistenten und zyklenfreien symbolischen Link anzubieten. In einer hierarchischen Sicht lässt sich durch Verweise ein Baum bilden, in dem eine Navigation und Verweisauflistung möglich sind, was außer ZIBDMS noch kein anderes System bietet.
    Description: The hierarchical organization of files has dominated computer systems for many years and this will probably not change in the near future. However, with the rapid annual growth of new data this classical hierarchical file system management method reaches its limitations, even when the user consistently sets up and continually expands an elaborated directory structure with well-disciplined naming. This paper introduces new management methods to maintain an overview of all files which can be embedded in the hierarchical file system. A metadata-based file system, which is based on the hierarchical file system, offers, in addition to hierarchical access, a more flexible and associative access to files via virtual objects by providing query capabilities of index- and metadata which are stored in a database. The query results are presented in a clearly-arranged form of virtual directories and virtual files so that the intuitive hierarchical view continues to be maintained. The data management system ZIBDMS, which contains a distributed metadata catalog and a file replication catalog, permits a transparent implementation of these management methods for the NFS interface, CORBA-middleware or web services. Furthermore, ZIBDMS provides other new file management methods that can be integrated into the hierarchical file system view. Metadata in form of attribute-value-pairs can be presented and edited with a virtual file. A Collection makes it possible to organize files in logical virtual folders. Using a Dependency graph, files can be related to each other and expressed through a link structure between these files. In the ZIBDMS the reference concept of a classical hierarchal file system is extended with a new kind of reference called Weak Link in order to provide up-to-date, consistent and cycle-free symbolic links. With the references a tree can be established in a hierarchical view in which navigation and listing of references are possible; this capability is only possible in the ZIBDMS system.
    Keywords: ddc:000
    Language: German
    Type: masterthesis , doc-type:masterThesis
    Format: application/pdf
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  • 156
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    Psychopharmacology 14 (1969), S. 18-22 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Animal Behaviour ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mice were stained with pulverized charcoal and the resulting grooming behaviour observed. From 119 controls, the typical patterns indicated a late cleaning of the tail, the sacrum and the region between the ears. The following substances were tested: Imipramine, Desipramine, Trimeprimine, Amitriptyline, Nortriptyline, Chlordiazepoxide, Iproniazide, d-Amphetamine, Chlorpromazine, Haloperidol, Acetylsalicylic acid, Metronidazole. Of these Amitriptyline, Chlorpromazine, Haloperidol and Metronidazole were effective in doses less than 1/10 of LD 5.
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  • 157
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    Psychopharmacology 14 (1969), S. 62-73 
    ISSN: 1432-2072
    Keywords: Amphetamine ; Hallucinogens ; Drug Addiction ; Psychopharmacology ; Phenylethylamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The amphetamine analog, 2,5-dimethoxy-4-methylamphetamine (DOM), was studied in 18 volunteer subjects given single doses ranging from 2 to 14 mg. The former was a threshold dose, with definite psychotomimetic effects being evident from doses over 5 mg. The clinical syndrome greatly resembled that of the LSD-mescaline-psilocybin series of drugs, including its time-course. Somewhat more sedation was produced by DOM than would have been expected from the others, despite concomitant evidence of peripheral sympathetic stimulation. Just as with the other drugs, DOM increased plasma free fatty acids, decreased phosphorus and creatinine clearance, decreased circulating eosinophils and had little effect on catecholamine excretion. Performance of psychometric tests was impaired. Chlorpromazine treatment concurrently was found to attenuate the reaction. Tolerance rapidly developed when the drug was used chronically by patients.
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  • 158
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    Psychopharmacology 14 (1969), S. 200-210 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Hashish ; Cannabinoids ; Monkeys Amphetamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The psychopharmacological activity of Δ 1-tetrahydrocannabinol, (I); Δ 1(6)-tetrahydrocannabinol (4′ hexyl), (II); Δ 1(6)-tetrahydrocannabinol, (III); 1-ethoxyhexahydrocannabinol, (IV); 8-ethoxy-iso-hexahydrocannabinol, (V); Δ 1(6)-tetrahydrocannabinolic acid Me ester, Isomer I, (VI); Δ 1(6)-tetrahydrocannabinolic acid Me ester, Isomer II, (VII); cannabigerol, (VIII); Δ 1(6)-tetrahydrocannabinol (3′ hexyl), (IX); cannabichromene, (X); has been examined in a variety of animal species. 2. Compounds (I) and (III) caused severe motor disturbances and a stuporous state in dogs and ptosis, “tameness” and peculiar postural changes in monkeys. In the latter animal, compound (II) elicited similar effects. 3. Compounds (I) and (III) after intraperitoneal but not subcutaneous administration, suppressed the gerbil digging activity; reduced the rat conditioned avoidance response and induced a cataleptoid reaction in mice, rats and gerbils. In addition, compound (I) reduced the performance of mice on the rotating-rod. Both compounds, administered subcutaneously, induced a measurable ataxic gait in rats. 4. Amphetamine reversed the behavioural changes elicited by compounds (I) and (III) in monkeys, as well as the cataleptoid reaction in rats. 5. None of the other compounds provoked observable changes in any of the species studied. 6. It is suggested that Rhesus monkeys might serve as a suitable model for assessing the psychopharmacological activity of active cannabinoids.
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  • 159
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    Psychopharmacology 14 (1969), S. 394-403 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Morphine ; Skin Conductance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Skin conductance changes during periods of stress induced by hypercapnia were studied during a cycle of addiction to morphine. Conductance changes were found to be dose dependent in both tolerant and non-tolerant states. The effects of morphine on skin conductance changes induced by hypercapnia were similar to those effects previously observed on changes induced by electric shock.
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  • 160
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    Psychopharmacology 15 (1969), S. 196-206 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Animal Behavior ; Alcohol ; Atropine ; Discrimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two operant procedures were used for training albino rats to make differential responses on the basis of their drug or nondrug condition. In the Conflict procedure, every fifth lever press was rewarded by a food pellet in one condition (drug for half the animals, saline for the other half) and was punished by electric shock in the other condition. For 6 animals the drug condition was ethyl alcohol (1200 mg/kg of a 10% v/v solution in isotonic saline, injected i.p. 5 min before the start of the session); for 4 animals the drug condition was atropine sulfate (10 mg/kg in 1 ml/kg saline injected i.p. 30 min before the start of the session). In the Choice procedure, food reward was obtained by the first press on one of two levers at a variable time interval, averaging one minute, after the prior food reward. The rewarded lever depended on the animal's drug or saline condition (alcohol for 7 animals, atropine for 5 animals, administered as in the Conflict procedure); the same right-hand or left left-hand lever was rewarded in the drug condition for half the animals and in the saline condition for the other half. The response associated with 1200 mg/kg alcohol was generally elicited in tests with sufficiently high doses of pentobarbital sodium (10–20 mg/kg), chlordiazepoxide hydrochloride (10–15 mg/kg) and chloral hydrate (90–120 mg/kg, administered orally). Lower doses of these compounds, and of alcohol, were perceived as less similar to the alcohol and therefore more similar to the saline condition. Substantial doses of chlorpromazine hydrochloride (2 mg/kg) and d-amphetamine sulfate (1 mg/kg) also were perceived as similar to the saline condition. The response associated with a centrally acting anticholinergic (10 mg/kg atropine) was generally elicited in tests with several doses of scopolamine hydrobromide (0.06 to 1.0 mg/kg) and of atropine (2.5–5.0 mg/kg). The saline response was elicited by a lower dose of scopolamine (0.03 mg/kg) and by a peripherally-acting anticholinergic, atropine methyl bromide, at a dose (5 mg/kg) equimolar with 10 mg/kg atropine sulfate. The same results, including closely similar ED50 doses, were generally found with the Conflict and Choice procedures, despite the differences between them in the motivational basis for the differential drug and nondrug responses. The similarities and dissimilarities among these compounds in perceived stimulus characteristics also correspond closely with those reported by Overton (1966) with a locomotor shock-escape procedure in tests which were generally limited to a single high dose of each drug.
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  • 161
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    Psychopharmacology 15 (1969), S. 245-254 
    ISSN: 1432-2072
    Keywords: Aggression ; Lithium ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of lithium on aggressive behavior was studied in Siamese fighting fish, mice and golden hamsters. The fish stopped fighting when exposed to concentrations of 10 to 30 meq/l LiCl in the surrounding water. Also in mice and hamsters which ingested LiCl with the drinking fluid lithium abolished intraspecific aggression. Measurements of plasma and brain lithium levels revealed astonishing individual differences in the concentrations which were necessary for the antiaggressive effect. In all species normal aggressive behavior reappeared after lithium treatment was discontinued.
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  • 162
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Antidepressants ; Reserpine Emesis ; Apomorphine Pecking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven psychic energizers have been quantitatively evaluated for their antidepressant and tranquillizing activity using antagonism of reserpine induced emesis and apomorphine induced pecking in pigeons as test procedures for the two activities respectively. Pheniprazine and deanol possess anti-reserpine activity only whereas imipramine, desmethylimipramine, amitriptyline, opipramol and orphenadrine possess both anti-reserpine as well as anti-apomorphine activity. It is suggested that the two tests form a simple and reliable combination for evaluating potential antidepressants.
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  • 163
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    Psychopharmacology 15 (1969), S. 425-429 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Methysergide ; Mania ; Lithium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six manic patients were studied in an open sequential drug trial of placebo and the serotonin antagonist methysergide; lithium was then substituted double-blind. No dramatic change occurred in individual manic item scores or in mean daily mania ratings after 48 hours or seven days of methysergide, although several of the patients showed slight trends toward improvement. However, after a mean duration of 10.3 days of lithium treatment, all manic item scores improved dramatically and significantly, so that complete clinical remission was evident in all patients. In view of the discrepancy between these essentially negative findings and several recent positive reports on the efficacy of methysergide in the treatment of mania, the authors feel that the indolealkylamine hypothesis of affective disorders should be further investigated.
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  • 164
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    Psychopharmacology 15 (1969), S. 109-115 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Hallucinogens ; Drug Effects ; Behavior Exploratory ; Monkeys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of Psilocybin on the behavior of the baboon Papiopapio has been studied. Animal watchfulness, as estimated from the E.E.G., is enhanced within the first five minutes after injection and then is not further modified. Psilocybin induces a decrease of spontaneous motility. Conversely, the frequency of eye movements is considerably increased. This pattern might be explained by alterations of visual perception.
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  • 165
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    Psychopharmacology 15 (1969), S. 134-143 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Anti-Anxiety ; Controlled Trial ; Doxepin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six patients with persistent anxiety symptoms were used in a preliminary assessment of a new anti-anxiety compound-Doxepin (Sinequan) with placebo. The factorial design is discussed as a potentially useful way of conducting a first-stage test of anti-anxiety compounds. Analysis of the results showed that Doxepin at 25 mg t.d.s. and 50 mg t.d.s. was associated with improvement in the patient's self ratings of anxiety symptoms.
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  • 166
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    Psychopharmacology 14 (1969), S. 142-149 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Amphetamine ; Cholinergics ; Drug Interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Amphetamine was administered to a group of rats trained on a nondiscriminated avoidance procedure. An intraperitoneal dose of 2.0 mg/kg caused about a 75% increase in response rate for the three-hour session. Doses of atropine, Tremorine, eserine, and 4-(1-naphthylvinyl)-pyridine (NVP), an inhibitor of the enzyme choline acetylase, which were ineffective in themselves, markedly affected the increase in rate observed after amphetamine. The quarternary amine of NVP was without effect on the amphetamine response. Those agents that decreased cholinergic function, either by blocking the effect of acetylcholine or by preventing its synthesis, augmented the stimulating effect of amphetamine. Cholinergic stimulants, on the other hand, significantly antagonized the behavioral effects of amphetamine.
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  • 167
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    Psychopharmacology 14 (1969), S. 417-425 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Psychoses ; Reflex, Abnormal ; Chlorpromazine ; Trifluopromazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary According to our results in 117 subjects, recently taken medications, age and sex must be considered when duration of the Achilles-tendon reflex is used as a clinical test to assess thyroid status. Males have a shorter ATR than females. In older subjects the ATR lasts longer than in those below age 27. Fifty-two psychiatric patients before medication did not differ in ATR duration from 65 controls. However, after 28 patients took chlorpromazine and 24 received trifluoperazine, ATR was prolonged in the chlorpromazine group and shortened in the trifluoperazine group. Neither chlorpromazine concentrate, 1,800 mg, nor trifluoperazine concentrate, 180 mg, given during the first six days, affected ATR, but an additional 6,000 mg of chlorpromazine, or an additional 420 mg of trifluoperazine over the next six days, did significantly alter ATR-duration.
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  • 168
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Doxepin ; Diazepam ; Anti-Anxiety ; Antidepressant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Doxepin and diazepam were evaluated for therapeutic effectiveness in a double blind study carried out with 69 primarily anxious neurotic outpatients attending either a municipal hospital clinic or a general practitioner's office. Doxepin produced more clinical improvement than diazepam in several questionnaire clusters measuring depressive symptomatology, but not in clusters measuring anxious symptomatology. According to several outcome criteria, doxepin tended to produce more clinical improvement in general practice than in clinic patients, while diazepam produced either equal improvement in both populations or slightly more improvement in the clinic. Possibly contributing to the present results are low daily dosage of diazepam, differential pharmacological drug effects, population differences in levels of anxiety and depression, and differences in population characteristics, primarily as related to social class.
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  • 169
    ISSN: 1432-2072
    Keywords: Nicotine ; Antimuscarinic Drugs ; Ganglion-Blocking Drugs ; Operant Conditioning ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of nicotine on bar-pressing behaviour in the rat are blocked by mecamylamine. The depressant phase of the effect is blocked by atropine, supporting the conclusion that this depression is mediated by released acetylcholine. The quaternary compounds chlorisondamine and atropine methylnitrate also antagonise the behavioural effects of nicotine but the doses required for this are far in excess of those which are effective peripherally, suggesting that the sites of interaction are central.
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  • 170
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    Psychopharmacology 15 (1969), S. 351-360 
    ISSN: 1432-2072
    Keywords: Nicotine ; Conditioned Stimulus ; Discrimination Learning ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats were trained to respond for water rewards on different bars in a Skinner box depending on whether they had previously been injected with nicotine or with saline. No other drug tested could consistently elicit responses on the “nicotine correct” bar. Pre-treatment with mecamylamine abolished the rats' ability to distinguish between nicotine and saline but pretreatment with chlorisondamine did not.
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  • 171
    ISSN: 1432-2072
    Keywords: Lysergic Acid Diethylamide or LSD ; Methylphenidate or Ritalin ; Chlordiazepoxide or Librium ; Psychopharmacology ; Alcoholism and Drug Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Through the retrospective use of the 156 item DWM Card Sort, the experiences from a single intravenous dose of 200 mcg of LSD, 75 mg of methylphenidate (Ritalin) and 75 mg of chlordiazepoxide (Librium) were compared in a population of 99 chronic male alcoholics treated in an “LSD setting” in a double-blind study. Surprisingly, 96 of the 156 items proved significantly different among the 3 groups. LSD was unique in producing Sensory and Perceptual Distortions (including Hallucinations or Illusions), and Mystical, Religious or Paranormal Sensations. However, contrary to expectation, LSD did not uniquely produce the traditional “therapeutic” experience, but appeared to be surpassed in that area by methylphenidate. Both drugs also produced some anxiety, while chlordiazepoxide produced relaxation, and enhanced music appreciation.
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  • 172
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    Psychopharmacology 14 (1969), S. 248-254 
    ISSN: 1432-2072
    Keywords: Amphetamine ; Appetite Depressants ; Psychopharmacology ; Sympathomimetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method is described with which it is possible to measure locomotor activity and food intake simultaneously in the same rat or other small animal. From a study of a number of psychomotorstimulant drugs and anorectic agents it may be concluded that locomotorstimulation and appetite-suppression are two different effects that may or may not characterize the same drug. Methamphetamine and phenmetrazine are stimulants in doses that do not inhibit food intake. Amphepramon reduced food intake in low doses but acts as a stimulant in higher doses. Chlorphemternine and phenfluramine are anorectic agents that are not stimulants, even in high doses.
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  • 173
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    Psychopharmacology 15 (1969), S. 1-8 
    ISSN: 1432-2072
    Keywords: Cannabis (Marihuana) ; Lysergic Acid Diethylamide ; Hallucinogens (Psychopharmacology) ; Visual Perception ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four pigeons were trained on a visual discrimination task which required conditional responding along the independent dimensions of form and color. High doses of Cannabis sativa (marihuana) extract and lysergic acid diethylamide (LSD), which were equated on the basis of their effectiveness in suppressing responding, increased responding on a color dimension but not on a form dimension. High doses of LSD produced a decrement in discrimination performance while comparable doses of Cannabis did not effect accuracy. Treatment with Bromolysergic acid diethylamide, saline, and pentobarbital did not produce significant changes in performance. Results are discussed in terms of a break-down in stimulus control and central hallucinogenic activity.
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  • 174
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    Psychopharmacology 15 (1969), S. 19-27 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Animal Behavior ; Nicotine-Physical Performance ; Motivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In sessions of ten runs each, swimming time of rats through a 4 m long water alley was measured. Four doses of nicotine (0.05; 0.1; 0.2; 0.4 mg/kg given intraperitoneally 30 minutes before testing) were tested in sessions with a braking load on the tails of the animals either in all 10 runs of a session, or in every second run, or in none of the 10 runs. Regardless of the swimming condition, nicotine produced a considerable, and at doses of 0.1 mg/kg and over, significant decrease of performance in the first two runs. From the third to the 10th run, the changes caused by nicotine were smaller and differed depending on the swimming conditions. A dose of 0.1 mg nicotine/kg improved performance in the “without-load-sessions” and the “without-load-runs” of the alternating sessions, while both 0.1 and 0.2 mg/kg improved performance of the “with-load-runs” of the alternating sessions. Performance in the “without-load-sessions” and the “without-load-runs” was depressed by 0.4 mg/kg and that in the “with-load-sessions” by 0.2 and 0.4 mg/kg.
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  • 175
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    Psychopharmacology 15 (1969), S. 28-38 
    ISSN: 1432-2072
    Keywords: Drugs ; Sleep ; Electroencephalography ; Psychophysiology ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sleep physiological patterns were examined following a single oral dose (500 mg) of the hypnotic drug alpha chloralose. The drug increased SW sleep and decreased REM sleep without affecting total sleep time or the amount of stage 2. These changes were accompanied by a shift to slower frequencies and greater EEG synchrony, as well as a decrease in the number of spontaneous arousals in all stages of sleep, and throughout the night of medication. Except for a slight decrease in eye movement density, the drug had no systematic effects on phasic phenomena such as electrodermal or cardio-respiratory fluctuations, nor was there a systematic change in basal heart and breathing rates. On the night following medication a “rebound” increase in percent stage REM was associated with a sharp decrease in SW sleep, and increases in spontaneous arousals and waking time. Such findings suggest that sleep stages are controlled by homeostatic mechanisms whose function is to maintain equilibrium. A comparison of the effects of alpha chloralose with those of the barbiturate secobarbital revealed some striking differences. Although both alpha chloralose and the barbiturate reduced the amount of stage REM and the frequency of brief arousals, the latter compound enhanced EEG fast activity and desynchrony, and suppressed such phasic phenomena as rapid eye movements during stage REM, sigma spindles in stage 2, nonspecific electrodermal responses during SW sleep and cardio-respiratory variability in all sleep stages. For secobarbital, the decrease in percent stage REM was compensated by an increase in stage 2 rather than SW sleep. Several studies in the cat suggest that in subanesthetic doses, alpha chloralose acts primarily on cortical inhibitory processes, causing release of the reticular activating system from inhibitory influences. The results of this study show that moderate doses in man probably act on both cortical and subcortical systems involved in the mediation of SW sleep, REM sleep and arousal.
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  • 176
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    Psychopharmacology 15 (1969), S. 64-72 
    ISSN: 1432-2072
    Keywords: Amphetamine ; Dextro Amphetamine ; Psychopharmacology ; Conditioning, Operant ; Pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bar pressing was maintained by food reinforcement of each fiftieth response (FR50 schedule). Rats were tested at 3 levels of food deprivation (60, 80 and 100% of ad libitum body weight) under three drug conditions (0, 0.2 and 0.4 mg of D-amphetamine per rat). Overall response rate was reduced by increasing doses of drug, but not significantly by deprivation, within the range studied. The components of response rate were analysed separately into the starting speed (latency of the first response of each ratio run of 50 responses) and running rate. Drug level affected running rate and first latency of the session, whereas body weight affected only first latency of the session. Only the first latency of the session showed an interaction of drug level and body weight. The lack of interaction raises the question, whether amphetamine is more properly administered as total dose per rat, rather than proportional to body weight.
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  • 177
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    Psychopharmacology 15 (1969), S. 144-152 
    ISSN: 1432-2072
    Keywords: Niacin ; Nicotinamide Adenine Dinucleotide ; Schizophrenia ; Phenothiazines ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two grams of NAD were administered orally to ten chronic schizophrenic patients for twenty-one days. Five of the patients were also receiving thioridazine. There was no gross clinical improvement noted in any of the patients despite the fact that related experiments suggested that the NAD was absorbed. In those patients who were not also receiving phenothiazines there was a distinct tendency towards increased hostility, aggressiveness and irritability beginning one week after the initiation of NAD treatment and lasting for nearly two weeks after the NAD was discontinued.
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  • 178
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    Psychopharmacology 14 (1969), S. 221-232 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Animal Behaviour ; Nicotine ; Punishment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of nicotine, amphetamine, chlordiazepoxide and caffeine were studied in rats trained on a VI 2 crf schedule of water reward with all rewards accompanied by electric shock. Responding, partially suppressed by the shock, was restored by chlordiazepoxide and further suppressed by amphetamine. Nicotine resembled amphetamine in its effects on most rats but occasionally increased responding. Caffeine also increased responding in some rats indicating that this property is not always confined to tranquillising drugs.
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  • 179
    ISSN: 1432-2072
    Keywords: Benzodiazepines ; Psychopharmacology ; Antianxiety ; Drug Tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oxazepam has two opposing actions on behavior: a responsedecreasing or depressant action and a response-increasing or disinhibitory action. The course of the two actions in chronic dosing was determined in rats in a test in which punished and unpunished schedules of reinforcement were alternated. The depressant action (measured by a decrease in the rate of unpunished behavior) was observed to undergo tolerance after 3–4 doses, while the disinhibitory action (measured by an increase in the rate of punished behavior) failed to show tolerance and even increased throughout the chronic series. The selective tolerance of the depressant action is probably due to neuronal adaptation, but changes in metabolism also may be involved. The increase in the rate of punished behavior is attributed, at least in part, to a progressive unmasking of the disinhibitory action as tolerance to the depressive action develops.
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  • 180
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    Psychopharmacology 13 (1968), S. 118-128 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Diagnosis ; Sampling Studies ; Statistics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Theoretical models for sample selection by diagnosis using one, one-out-of-two, two, two-out-of-three, and three concurring opinions are illustrated. These models are then applied to two categories, schizophrenia and depressive disorders, for an actual sample of patients diagnosed by multiple observers. The conclusion is reached that sample selection by a single opinion is not sufficiently reliable for research studies. The choice of alternative methods of selection depends on the needs of a particular study. Samples chosen on the basis of two-out-of-three concurring opinions provide the least total error. When erroneous inclusions are particularly undesirable, higher degrees of consensus—e.g. agreeing pairs or triplets—are necessary.
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  • 181
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    Psychopharmacology 13 (1968), S. 129-139 
    ISSN: 1432-2072
    Keywords: Electroencephalography ; Psychopharmacology ; Imipramine ; Amphetamine ; Physostigmine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The results of the interaction of imipramine, physostigmine and d/l amphetamine in various intravenously administered dosages were studied on the cortical and subcortical electrical activity of cats. Imipramine was shown to cause a cortical synchronization, hippocampal desynchronization, rise in the threshold of electrocortical arousal and limbic convulsive activity which was potentiated by amphetamine. Imipramine increased the amount of physostigmine, but decreased the amount of amphetamine needed for cortical desynchronization. The possible significance of these findings for the neuropsychopharmacological action of imipramine is briefly discussed.
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  • 182
    ISSN: 1432-2072
    Keywords: Indoleamine Metabolism ; Psychopharmacology ; Antidepressive Drugs ; Amphetamine Derivatives (Chlorinated) ; Depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary CMA (p-chloro-N-methylamphetamine) lowers the cerebral 5-HT concentration in test animals but has virtually no effect on the catecholamine concentrations. Moreover, this compound was found to behave in depressive patients like an antidepressive drug, not like a central stimulant of the amphetmine type. The study described was conducted in order to establish whether CMA influences the overall metabolism of indoleamines in man. Such an influence was clearly demonstrable. Our findings are consistent with the hypothesis that CMA releases 5-HT from its depots. It has not been explained why a considerable proportion of the released 5-HT is excreted unchanged and why the increase in 5-HIAA excretion is so small: the overall activity of MAO was found not to be inhibited. No indications of abnormal 5-HT degradation were found at this time. Patients with vital depressions who improved on CMA medication showed a lower 5-HIAA excretion before treatment than did patients who were refractory to CMA treatment. This is consistent with earlier observations. The possible cause of this phenomenon is discussed. Among the various possibilities considered, an abnormal 5-HT metabolism is regarded as the most plausible. Pertinent investigations are being continued.
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  • 183
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    Psychopharmacology 12 (1968), S. 384-399 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Tranquilizing Agents ; Chlordiazepoxide ; Frustration ; Animal Behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This experiment investigated the possibility that chlordiazepoxide (CDP) has unique properties that account for state dependent learning, and prevention of conflict-induced behavior fixations. One group of rats were given a discrimination problem on a Lashley jumping stand, but on even days all responses were punished. Another group were treated the same way except than on even days all responses were rewarded. Each of these groups were subdivided, half of the Ss were given CDP on even days, the other half no drug. The results showed that punishment on even days for the response to be learned disrupted learning more than reward for responses that were to be avoided. CDP practically eliminated these disruptive effects and aided learning for the punishment group, but led to a slower rate of learning for the reward group. These findings confirmed the hypothesis that CDP attenuates the effects of negative incentives, and that this property accounts for the drug's cue value in discrimination learning and for its fixation prevention characteristics.
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  • 184
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    Psychopharmacology 12 (1968), S. 371-383 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Cholinergic Blocking Drugs ; Animal Behavior ; Scopolamine ; Conditioned Reflex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Atropine or scopolamine improved conditioned avoidance behavior for most rats which performed poorly, in spite of extensive training, in a shuttle-box procedure. As previously reported, d-amphetamine also improved performance in many of these animals, but there was no particular relationship between a rat's responses to the cholinergic blocking agents and to d-amphetamine. The effect of any one of the 3 agents was, for the most part, reversible after the drug effect had dissipated. Physostigmine was quite potent in disrupting avoidance behavior in rats that performed well in the shuttle-box, even in animals that were overtrained. This impairment was antagonized by atropine or scopolamine, partly antagonized by d-amphetamine, and not antagonized by methyl atropine. Poor performers were found to be very sensitive to the disruptive effects of physostigmine, losing much of their escape behavior after relatively small doses. The results are interpreted as evidence for a central cholinergic system with inhibitory influences for modulating stimulus-response patterns. Under normal circumstances this inhibitory system probably functions in an integrated manner with the adrenergic mobilizing system for the central control of learned behavior. Centrally-active anticholinergic drugs of the muscarinic type appear to influence behavioral responses by inducing a response disinhibition.
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  • 185
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Electrophysiology ; Arousal ; Animal Behavior ; Brain Biogenic Amines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have studied the interactions of reserpine and the monoamine oxidase inhibitors, nialamide and isocarboxazid, in rabbits. EEG recordings were made from animals with acute and chronically implanted electrodes. Gross behavioral observations were made in freely moving rabbits and brain amine concentrations of norepinephrine and serotonin were also determined. Emphasis was placed on observing drug effects over periods of time ranging up to 13 days. Rabbits given isocarboxazid or nialamide alone exhibit a phenomenon rarely seen in the control animals, namely partial activation, an EEG pattern in which slow waves of high amplitude are maintained in the cortex while fast activity appears in subcortical structures. This effect was also observed in rabbits treated with nialamide and reserpine in combination. By appropriate dosage schedules in which reserpine was administered to animals pretreated with monoamine oxidase inhibitors it was possible to maintain extended periods of frank arousal or EEG activation over a period of several days. The absolute concentrations of brain amines bore little or no relationship to the EEG effects observed, however, increased ratios of serotonin to norepinephrine were observed in conjunction with EEG activation and signs of behavioral excitement.
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  • 186
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    Psychopharmacology 12 (1968), S. 414-423 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Barbiturates ; Phenothiazines ; Animal Behavior ; Motor Coordination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The rotarod test of motor coordination in mice was modified by increasing the rotation speed every 30 sec until the animals fell off. This procedure yielded a stable, proficient level of performance within four brief trials; the approximately normal distribution of performance times provided an equivalent measure of either improvement or impairment caused by drugs and permitted the use of parametric statistical tests. A total of 240 mice were assigned to 20 different groups of 12 each, administered oral doses of placebo or different drugs, prior to trial 4. The use of a ratio score (performance time in trial 4 divided by the same animal's time in trial 3) provided a measure of drug-induced changes, controlling for individual differences among animals in over-all level of performance. Two phenothiazines (chlorpromazine and perphenazine) impaired performance at low doses, with a progressively greater decrement at increasing doses (4, 8, 16 mg/kg); 2 barbiturates (pentobarbital and amobarbital) showed an all-or-none effect, with no significant decrement at the lower doses (20 and 40 mg/kg) but almost complete incapacitation at the highest dose of 80 mg/kg. Performance superior to the placebo condition was found with the 2 lower doses of pentobarbital and with 3 d-amphet-amine doses (4, 8, 16 mg/kg). An analysis of individual differences gave evidence that the animals which were inferior in prior performance were more susceptible to both improvement and impairment of performance under the influence of drugs.
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  • 187
    ISSN: 1432-2072
    Keywords: Central Nervous System ; Psychopharmacology ; DDT ; Parathion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The offspring of female mice treated with 2.5 mg/kg DDT during the second or third trimester of pregnancy showed a delayed acquisition of the conditioned avoidance response. If DDT was given in the first trimester, or if 3 mg/kg of Parathion was given during the pregnancy, no effect on the conditioned avoidance response of the off-spring was seen.
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  • 188
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    Psychopharmacology 12 (1968), S. 428-432 
    ISSN: 1432-2072
    Keywords: Ganglia, Basal ; Psychopharmacology ; Chlorpromazine ; Amphetamine ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In rats micro-injections in corpus striatum of quaternary chlorpromazine and related drugs give rise to highly characteristic neuroleptic effects: antagonism of amphetamine-induced stereotyped behaviour and development of catalepsy. There is no effect of injections in hippocampus or septum. Dopaminergic mechanisms in corpus striatum seem to play a central role in neuroleptic action.
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  • 189
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    Psychopharmacology 13 (1968), S. 161-169 
    ISSN: 1432-2072
    Keywords: Sleep-wakefulness Cycle ; Amphetamine ; Psychopharmacology ; Growing Animals ; Electrencephalography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The effects of amphetamine on the sleep-wakefulness cycle were studied in 48 kittens during the growth period of 1–28 days of age. Recordings of EEG, EMG of the posterior neck muscles and respiratory rhythms were made as well as observations of gross behavior. 2. Percent time of wakefulness was increased with amphetamine (0.3 mg/kg). This effect became more marked with age, i.e., being more significant after 16 to 18 days of age (P〈0.005) than before (P〈0.05). These increases in the intensity of the effect during growth may be related to the postnatal development of the structures responsible for wakefulness. 3. Percent time of “activated” sleep was diminished significantly at all ages including the newborns (P〈0.005). This lack of the influence of age suggests that the structures responsible for “activated” sleep are well developed at birth. 4. The increase of percent time of slow wave sleep was observed. This increase is regarded as a “passive” manifestation of time left available after a severe diminution of “activated” sleep time and relatively slight increase of wakefulness time during amphetamine medication.
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  • 190
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    Psychopharmacology 13 (1968), S. 210-221 
    ISSN: 1432-2072
    Keywords: Psychopharmacology ; Animal Behaviour ; Nicotine ; Physostigmine ; Motor Activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats of 3 strains were observed at regular intervals and their activity was recorded using four categories of behaviour-rearing, moving, grooming and immobile. Strain differences in control activity were found. Nicotine and physostigmine reduced the activity of the more active rats and increased that of the less active animals. Rearing behaviour was particularly susceptible to depression by both drugs. The similarity of effect of the two drugs supports the hypothesis that one of the actions of nicotine in the brain is the release of acetylcholine.
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  • 191
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    Psychopharmacology 13 (1968), S. 287-298 
    ISSN: 1432-2072
    Keywords: Motion Pictures ; Motor Skills ; Eye Movements ; Psychopharmacology ; Psychological Tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Measures of skilled motor performances, both of a task-oriented (tests of eye-hand coordination) and incidental (control of facial and ocular muscles) nature were recorded for a sample of 20 healthy young adults before and after single administrations of perphenazine, opipramol, imipramine and placebo at doselevels commonly supposed to produce mood or behavioral effects. It was anticipated that such performances would be sensitive even to slight changes in the subjects' physiological and psychological state; the aim was to test the power of tests of subtle skills in providing indices of slight to moderate behavioral effects. The performance measures remained surprisingly little affected by all drugs, despite their sensitivity to drug-independent improvement in performance throughout the experimental day, and despite evidences of drug-related effects, especially for imipramine and opipramol, in simple objective physiological measures, and for imipramine alone in subjective measures taken concurrently. There may be a class of skilled sensory-motor acts, particularly those related to well-learned daily activities, which, rather than being vulnerable to adverse effect, remain efficient even in the presence of signs of disturbance of bodily function.
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  • 192
    ISSN: 1432-2072
    Keywords: Cannabis ; Lysergic Acid Diethylamide ; Mescaline ; Hallucinogens ; Psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using climbing rope and bar-pressing behavior methods, rats were rendered tolerant to Δ 9-THC, cannabis extract, mescaline and LSD-25. Cross-tolerance experiments showed that rats refractory to Δ 9-THC and cannabis extract were still sensitive to mescaline and LSD-25, and vice-versa. These results suggest that, in spite of the similarity of the clinical symptoms produced in man by the 3 drugs, Δ 9-THC may have its psychotomimetic effects produced by different mechanisms from those of LSD-25 and mescaline.
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